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Conserved domains on  [gi|2086780375|gb|KAG9308529|]
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AP complex, mu/sigma subunit [Chiua virens]

Protein Classification

AP-2 complex subunit sigma( domain architecture ID 13000710)

AP-2 complex subunit sigma is a component of the adaptor protein complex 2 (AP-2) that functions in protein transport via transport vesicles in different membrane traffic pathways

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AP2_sigma cd14833
AP-2 complex subunit sigma; AP-2 complex sigma subunit is part of the heterotetrameric adaptor ...
 1-142 4.53e-94

AP-2 complex subunit sigma; AP-2 complex sigma subunit is part of the heterotetrameric adaptor protein (AP)-2 complex which consists of one large alpha-, one beta-, one mu-, and one sigma-subunit. AP complexes link the cytosolic domains of the cargo proteins to the protein coat that induces vesicle budding in the donor compartment during vesicle transport. In the case of AP-2 the coat protein is clathrin. AP-2 binds the phospholipid PI(4,5)P2 which is important for its localisation to the plasma membrane. The sigma subunit is comprised of a single longin domain and plays a role in binding dileucine-based sorting signals.


:

Pssm-ID: 341437  Cd Length: 141  Bit Score: 267.90  E-value: 4.53e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086780375   1 MIRFILVQNRQGKTRLSKWYVPYDDEEKVRLRGEVHRLVAPRDQKyQSNFVEFKNHKIVYRRYAGLFFCVCVDANDNELA 80
Cdd:cd14833     1 MIRFILIQNRQGKTRLAKWYVPYDDDEKQKLEEEVHRLVTSRDKK-HTNFVEFRNYKLVYRRYAGLFFCICVDVNDNELA 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2086780375  81 YLEAIHLFVEILDSFFDNVCELDLVFNFYKVYAILDEIFLAGEIEETSKEVVLQRLEELEKL 142
Cdd:cd14833    80 YLEAIHLFVEVLDEYFGNVCELDLVFNFYKVYAILDEMFLAGEIQETSKKVILERLKELDKL 141
 
Name Accession Description Interval E-value
AP2_sigma cd14833
AP-2 complex subunit sigma; AP-2 complex sigma subunit is part of the heterotetrameric adaptor ...
 1-142 4.53e-94

AP-2 complex subunit sigma; AP-2 complex sigma subunit is part of the heterotetrameric adaptor protein (AP)-2 complex which consists of one large alpha-, one beta-, one mu-, and one sigma-subunit. AP complexes link the cytosolic domains of the cargo proteins to the protein coat that induces vesicle budding in the donor compartment during vesicle transport. In the case of AP-2 the coat protein is clathrin. AP-2 binds the phospholipid PI(4,5)P2 which is important for its localisation to the plasma membrane. The sigma subunit is comprised of a single longin domain and plays a role in binding dileucine-based sorting signals.


Pssm-ID: 341437  Cd Length: 141  Bit Score: 267.90  E-value: 4.53e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086780375   1 MIRFILVQNRQGKTRLSKWYVPYDDEEKVRLRGEVHRLVAPRDQKyQSNFVEFKNHKIVYRRYAGLFFCVCVDANDNELA 80
Cdd:cd14833     1 MIRFILIQNRQGKTRLAKWYVPYDDDEKQKLEEEVHRLVTSRDKK-HTNFVEFRNYKLVYRRYAGLFFCICVDVNDNELA 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2086780375  81 YLEAIHLFVEILDSFFDNVCELDLVFNFYKVYAILDEIFLAGEIEETSKEVVLQRLEELEKL 142
Cdd:cd14833    80 YLEAIHLFVEVLDEYFGNVCELDLVFNFYKVYAILDEMFLAGEIQETSKKVILERLKELDKL 141
APS2 COG5030
Clathrin adaptor complex, small subunit [Intracellular trafficking and secretion];
1-143 2.44e-65

Clathrin adaptor complex, small subunit [Intracellular trafficking and secretion];


Pssm-ID: 227363  Cd Length: 152  Bit Score: 195.71  E-value: 2.44e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086780375   1 MIRFILVQNRQGKTRLSKWYVPYDDEEKVRLRGEVHRLVAPRDQKyQSNFVEFKNHKIVYRRYAGLFFCVCVDANDNELA 80
Cdd:COG5030     1 MIKFVLIFNRQGKPRLVKWYTPVSDPEQAKLIADIYELISARKPK-ESNFIEGKNEKIVYRRYATLYFVFGVDNDDNELI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2086780375  81 YLEAIHLFVEILDSFFDNVCELDLVFNFYKVYAILDEIFLAGEIEETSKEVVLQRLEELEKLE 143
Cdd:COG5030    80 ILELIHNFVEILDRFFGNVCELDLIFNFQKVYAILDEMILGGEIIESSKNEVLEHVYALDAES 142
Clat_adaptor_s pfam01217
Clathrin adaptor complex small chain;
1-143 1.11e-60

Clathrin adaptor complex small chain;


Pssm-ID: 460115  Cd Length: 142  Bit Score: 183.33  E-value: 1.11e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086780375   1 MIRFILVQNRQGKTRLSKWYVPYDDEEKVRLRGEVHRLVAPRDQKYqSNFVEFKNHKIVYRRYAGLFFCVCVDANDNELA 80
Cdd:pfam01217   1 MIKAILIFNRQGKPRLAKWYTPYSDPEQQKLIEQIYALISARKPKM-SNFIEFNDLKVIYKRYATLYFVVIVDDQDNELI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2086780375  81 YLEAIHLFVEILDSFFDNVCELDLVFNFYKVYAILDEIFLAGEIEETSKEVVLQRLEELEKLE 143
Cdd:pfam01217  80 ILELIHRFVESLDRYFGNVCELDLIFNFEKVYLILDEMVMGGEILETSKNEVLHRVALLDELA 142
 
Name Accession Description Interval E-value
AP2_sigma cd14833
AP-2 complex subunit sigma; AP-2 complex sigma subunit is part of the heterotetrameric adaptor ...
 1-142 4.53e-94

AP-2 complex subunit sigma; AP-2 complex sigma subunit is part of the heterotetrameric adaptor protein (AP)-2 complex which consists of one large alpha-, one beta-, one mu-, and one sigma-subunit. AP complexes link the cytosolic domains of the cargo proteins to the protein coat that induces vesicle budding in the donor compartment during vesicle transport. In the case of AP-2 the coat protein is clathrin. AP-2 binds the phospholipid PI(4,5)P2 which is important for its localisation to the plasma membrane. The sigma subunit is comprised of a single longin domain and plays a role in binding dileucine-based sorting signals.


Pssm-ID: 341437  Cd Length: 141  Bit Score: 267.90  E-value: 4.53e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086780375   1 MIRFILVQNRQGKTRLSKWYVPYDDEEKVRLRGEVHRLVAPRDQKyQSNFVEFKNHKIVYRRYAGLFFCVCVDANDNELA 80
Cdd:cd14833     1 MIRFILIQNRQGKTRLAKWYVPYDDDEKQKLEEEVHRLVTSRDKK-HTNFVEFRNYKLVYRRYAGLFFCICVDVNDNELA 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2086780375  81 YLEAIHLFVEILDSFFDNVCELDLVFNFYKVYAILDEIFLAGEIEETSKEVVLQRLEELEKL 142
Cdd:cd14833    80 YLEAIHLFVEVLDEYFGNVCELDLVFNFYKVYAILDEMFLAGEIQETSKKVILERLKELDKL 141
APS2 COG5030
Clathrin adaptor complex, small subunit [Intracellular trafficking and secretion];
1-143 2.44e-65

Clathrin adaptor complex, small subunit [Intracellular trafficking and secretion];


Pssm-ID: 227363  Cd Length: 152  Bit Score: 195.71  E-value: 2.44e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086780375   1 MIRFILVQNRQGKTRLSKWYVPYDDEEKVRLRGEVHRLVAPRDQKyQSNFVEFKNHKIVYRRYAGLFFCVCVDANDNELA 80
Cdd:COG5030     1 MIKFVLIFNRQGKPRLVKWYTPVSDPEQAKLIADIYELISARKPK-ESNFIEGKNEKIVYRRYATLYFVFGVDNDDNELI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2086780375  81 YLEAIHLFVEILDSFFDNVCELDLVFNFYKVYAILDEIFLAGEIEETSKEVVLQRLEELEKLE 143
Cdd:COG5030    80 ILELIHNFVEILDRFFGNVCELDLIFNFQKVYAILDEMILGGEIIESSKNEVLEHVYALDAES 142
AP1_sigma cd14831
AP-1 complex subunit sigma; AP-1 complex sigma subunit is part of the heterotetrameric adaptor ...
 3-143 1.80e-63

AP-1 complex subunit sigma; AP-1 complex sigma subunit is part of the heterotetrameric adaptor protein (AP)-1 complex which consists of one large gamma-, one beta-, one mu-, and one sigma-subunit. AP complexes link the cytosolic domains of the cargo proteins to the protein coat that induces vesicle budding in the donor compartment during vesicle transport. In the case of AP-1 the coat protein is clathrin. AP-1 binds the phospholipid PI(4)P which plays a role in its localisation to the trans-Golgi network (TGN)/endosome. The sigma subunit is comprised of a single longin domain and plays a role in binding dileucine-based sorting signals.


Pssm-ID: 341435  Cd Length: 143  Bit Score: 190.46  E-value: 1.80e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086780375   3 RFILVQNRQGKTRLSKWYVPYDDEEKVRLRGEVHRLVAPRDQKyQSNFVEFKNHKIVYRRYAGLFFCVCVDANDNELAYL 82
Cdd:cd14831     1 HFLLLFSRQGKVRLSKWYSAYSQKEKAKITREVSTLVLARKPK-MCNFLEWRDLKIVYKRYASLYFVCCVDKDDNELITL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2086780375  83 EAIHLFVEILDSFFDNVCELDLVFNFYKVYAILDEIFLAGEIEETSKEVVLQRLEELEKLE 143
Cdd:cd14831    80 EIIHRYVEILDKYFGNVCELDIIFNFHKAYFILDELLLGGELQETSKKNVLRAIEAQDLLQ 140
Clat_adaptor_s pfam01217
Clathrin adaptor complex small chain;
1-143 1.11e-60

Clathrin adaptor complex small chain;


Pssm-ID: 460115  Cd Length: 142  Bit Score: 183.33  E-value: 1.11e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086780375   1 MIRFILVQNRQGKTRLSKWYVPYDDEEKVRLRGEVHRLVAPRDQKYqSNFVEFKNHKIVYRRYAGLFFCVCVDANDNELA 80
Cdd:pfam01217   1 MIKAILIFNRQGKPRLAKWYTPYSDPEQQKLIEQIYALISARKPKM-SNFIEFNDLKVIYKRYATLYFVVIVDDQDNELI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2086780375  81 YLEAIHLFVEILDSFFDNVCELDLVFNFYKVYAILDEIFLAGEIEETSKEVVLQRLEELEKLE 143
Cdd:pfam01217  80 ILELIHRFVESLDRYFGNVCELDLIFNFEKVYLILDEMVMGGEILETSKNEVLHRVALLDELA 142
AP_sigma cd14827
AP complex subunit sigma; AP complex sigma subunits are part of the heterotetrameric adaptor ...
 3-141 2.33e-59

AP complex subunit sigma; AP complex sigma subunits are part of the heterotetrameric adaptor protein (AP) complex which consists of one large subunit (alpha-, gamma-, delta- or epsilon), one beta-, one mu-, and one sigma-subunit. In general, AP complexes link the cytosolic domains of the cargo proteins to the protein coat that induces vesicle budding in the donor compartment during vesicle transport. In most cases the coat protein is clathrin (AP1 and AP2 complex), but some of the other members of the AP complex family are associated with nonclathrin coats. The sigma subunit is comprised of a single longin domain and plays a role in binding dileucine-based sorting signals.


Pssm-ID: 341431  Cd Length: 138  Bit Score: 179.94  E-value: 2.33e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086780375   3 RFILVQNRQGKTRLSKWYVPYDDEEKVRLRGEVHRLVAPRDQKyQSNFVEFKNHKIVYRRYAGLFFCVCVDANDNELAYL 82
Cdd:cd14827     1 RFILLFNRQGKTRLAKWYMQFDDDERQKLIEEIVQVVLSRDAK-HCNFVEFRNYKLIYRRYASLYFCICVDSNDNELAIL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2086780375  83 EAIHLFVEILDSFFDNVCELDLVFNFYKVYAILDEIFLAGEIEETSKEVVLQRLEELEK 141
Cdd:cd14827    80 EAIHNFVETLDKYFENVCELDLIFNFEKVYFIVDEMVLGGEIRETSQTKILKQIEMLDK 138
AP4_sigma cd14832
AP-4 complex subunit sigma; AP-4 complex sigma subunit is part of the heterotetrameric adaptor ...
 3-141 3.72e-48

AP-4 complex subunit sigma; AP-4 complex sigma subunit is part of the heterotetrameric adaptor protein (AP)-1 complex which consists of one large epsilon-, one beta-, one mu-, and one sigma-subunit. AP complexes link the cytosolic domains of the cargo proteins to the protein coat that induces vesicle budding in the donor compartment during vesicle transport. AP-4 does not bind the coat protein clathrin, it is associated with nonclathrin coats. Its phospholipid binding partner is unknown and it is localized in the trans-Golgi network (TGN). The sigma subunit is comprised of a single longin domain and plays a role in binding dileucine-based sorting signals.


Pssm-ID: 341436  Cd Length: 138  Bit Score: 151.62  E-value: 3.72e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086780375   3 RFILVQNRQGKTRLSKWYVPYDDEEKVRLRGEVHRLVAPRDqKYQSNFVEFKNHKIVYRRYAGLFFCVCVDANDNELAYL 82
Cdd:cd14832     1 KFILMVNKQGQTRLAQYYEFLSIEERVALEGEIIRKCLSRS-EKQCSFLEYRGYKLVYRRYASLYFIVGVDEDENELAIL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2086780375  83 EAIHLFVEILDSFFDNVCELDLVFNFYKVYAILDEIFLAGEIEETSKEVVLQRLEELEK 141
Cdd:cd14832    80 EFIHNLVETLDKYFENVCELDIMFNLEKAHFILDEMVMNGCIVETNKSNILAPILLMDK 138
AP3_sigma cd14834
AP-3 complex subunit sigma; AP-3 complex sigma subunit is part of the heterotetrameric adaptor ...
 1-141 3.13e-42

AP-3 complex subunit sigma; AP-3 complex sigma subunit is part of the heterotetrameric adaptor protein (AP)-1 complex which consists of one large delta-, one beta-, one mu-, and one sigma-subunit. AP complexes link the cytosolic domains of the cargo proteins to the protein coat that induces vesicle budding in the donor compartment during vesicle transport. AP-3 binds the coat protein clathrin and the phospholipid PI(3)P and it is localized in the endosome. The sigma subunit is comprised of a single longin domain and plays a role in binding dileucine-based sorting signals.


Pssm-ID: 341438  Cd Length: 146  Bit Score: 136.97  E-value: 3.13e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086780375   1 MIRFILVQNRQGKTRLSKWYVPYDDEEKVRLRGEVHRLVAPRDQKYqSNFVEF------KNHKIVYRRYAGLFFCVCVDA 74
Cdd:cd14834     1 MIKAILIFNNHGKPRLSKFYQHYSEEKQQQIIRETFQLVSKRDDNV-CNFLEGgsliggSDTKLIYRHYATLYFVFCVDS 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2086780375  75 NDNELAYLEAIHLFVEILDSFFDNVCELDLVFNFYKVYAILDEIFLAGEIEETSKEVVLQRLEELEK 141
Cdd:cd14834    80 SESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHYILDEIVMGGMVLETNMTEILTAIEEQNK 146
AP_longin-like cd14823
Longin-like domains of AP complex subunits; AP complex sigma subunits are part of the ...
 4-135 4.69e-25

Longin-like domains of AP complex subunits; AP complex sigma subunits are part of the heterotetrameric adaptor protein (AP) complex which consists of one large subunit (alpha-, gamma-, delta- or epsilon), one beta-, one mu-, and one sigma-subunit. In general, AP complexes link the cytosolic domains of the cargo proteins to the protein coat that induces vesicle budding in the donor compartment during vesicle transport. In most cases the coat protein is clathrin (AP1 and AP2 complex), but some of the other members of the AP complex family are associated with nonclathrin coats. The sigma subunit is comprised of a single longin domain and plays a role in binding dileucine-based sorting signals.


Pssm-ID: 341427  Cd Length: 131  Bit Score: 92.58  E-value: 4.69e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086780375   4 FILVQNRQGKTRLSKWYVPYDDEEKVRLRGEVhrLVAPRDQKYQSNFVEFKNHKIVYRRYAGLFFCVCVDANDNELAYLE 83
Cdd:cd14823     2 AILVLDNDGKRLFAKYYDDTYPSVKEQKAFEK--NIFNKKHRTDSEIVLLEGLRVVYKSSIDLYFVVIGSKNENELLLLE 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2086780375  84 AIHLFVEILDSFFDNVCELDLVFNFYKVYAILDEIFLAGEIEETSKEVVLQR 135
Cdd:cd14823    80 VLNCLVDVLSEYFRKVEERAILENFEGLYFALDEIVDGGYIQETDPKQVVHF 131
Zeta-COP cd14829
zeta subunit of the F-COPI complex; Zeta subunit of the heterotetrameric F-COPI complex, which ...
 53-135 3.88e-03

zeta subunit of the F-COPI complex; Zeta subunit of the heterotetrameric F-COPI complex, which consists of one beta-, one gamma-, one delta-, and one zeta subunit, where beta- and gamma- subunits are related to the large adaptor protein (AP) complex subunits, and delta- and zeta- subunits are related to the medium and small AP subunits, respectively. F-COPI forms a coatomer together with the B-COPI subcomplex, which assembles with a small GTPase, ADP-ribosylation factor 1 (ARF1), playing an important role in the formation of COPI complex-coated vesicles. COPI complex-coated vesicles function in the early secretory pathway mediating the retrograde transport from the Golgi to the ER, and intra-Golgi transport.


Pssm-ID: 341433  Cd Length: 132  Bit Score: 35.21  E-value: 3.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086780375  53 FKNHKIVYRRYAGLFFCVCVDANDNELayleaihLFVEILDSFFD--------NVCELDLVFNFYKVYAILDEIFLAGEI 124
Cdd:cd14829    49 LDGLTVVYKSNIDLTFYVVGSSDENEL-------ILASVLNCLYDalslllrkNVEKRALLENLDLVLLALDEIVDGGII 121

                          90
                  ....*....|.
gi 2086780375 125 EETSKEVVLQR 135
Cdd:cd14829   122 LETDPTAIASR 132
AP2_Mu_N cd14836
AP-2 complex subunit mu N-terminal domain; AP-2 complex mu subunit is part of the ...
 59-118 5.66e-03

AP-2 complex subunit mu N-terminal domain; AP-2 complex mu subunit is part of the heterotetrameric adaptor protein (AP)-2 complex which consists of one large alpha-, one beta-, one mu-, and one sigma-subunit. AP complexes link the cytosolic domains of the cargo proteins to the protein coat that induces vesicle budding in the donor compartment during vesicle transport. In the case of AP-2 the coat protein is clathrin. AP-2 binds the phospholipid PI(4,5)P2 which is important for its localisation to the plasma membrane. The mu subunit is comprised of an N-terminal longin domain followed by a C-terminal domain which is involved in the binding of the Y-X-X-Phi sorting signal.


Pssm-ID: 341440  Cd Length: 140  Bit Score: 34.81  E-value: 5.66e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086780375  59 VYRRYAGLFFCVCVDANDNELAYLEAIHLFVEILDSFFDNVCELDLVFNFYKVYAILDEI 118
Cdd:cd14836    56 FHVRHGNLYLVAVTRSNVNAAMVFEFLYKLVQLFKSYFGKFNEDSIKNNFVLIYELLDEI 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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