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Conserved domains on  [gi|2047916283|gb|KAG6588627|]
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Phospholipase A-2-activating protein, partial [Cucurbita argyrosperma subsp. sororia]

Protein Classification

WD repeat PLAP family protein( domain architecture ID 10078051)

WD repeat PLAP family protein containing WD40, PFU, and PUL domains, similar to vertebrate phospholipase A-2-activating protein (PLAP or PLAA), a ubiquitin-binding protein involved in protein ubiquitination, sorting and degradation

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0043130
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 484-748 6.74e-60

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


:

Pssm-ID: 462428  Cd Length: 261  Bit Score: 202.95  E-value: 6.74e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 484 PKKGALVFDVAQFDGILKKIVEFNNGlladsDKKNYALPEIEVSRLGTLVKILKDTSHYHstkftDADVALLLNLLRSWP 563
Cdd:pfam08324   1 PQKTYLSFKKANLDKILKKLGEFNGG-----EPKVLALSPEELATLEALLSFLESSSSAS-----EADIELLLKILTSWP 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 564 CELLFPVIDTLRMTVLHPDGAIMLLKLVDSDdILLELIQKVTTPPAiGANLLTSIRLIANLFKNSGYYDWLQKRRSEIID 643
Cdd:pfam08324  71 PEDRFPALDLLRLLALDPRVAAYFAEEEGGK-TISTLLSLLISSGL-YALRMLALRLLCNLFSSPLGRQLLLSHFDSILS 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 644 AYSSCYSTA----NKAVQLSFSTLILNYAVLLI---EKKDFDGQCQVLSAAIEIAEEESLEADSKFRALVAIGSLMIEGG 716
Cdd:pfam08324 149 TLASLLSSSlldsNKNLRIALATLLLNYAVLLHkekSPLSEEDQVELLAALLEALSTEEEDSEALYRLLVALGTLVYAPD 228

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2047916283 717 DDMKRTAL-DFDVKSIARKASASKDAKIAEVGA 748
Cdd:pfam08324 229 GEVLADLAqVLDAASWVKKAKKKKEPRIKEVGS 261
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-289 1.20e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 203.34  E-value: 1.20e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  10 LRCELTGHEDDVRGICVCGNVG-IATSSRDRTVRFWNLDGRKYEQSkiLLGHTSFVGPLAWISPDEQypegrIVSGGMDT 88
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRT--LKGHTGPVRDVAASADGTY-----LASGSSDK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  89 FVFVWDLRTGERVQTLKGHQQQVTGIALDSGD--IVSSSVDCTLRRW--RNGQVVEFWGAHNAAIQSVIKLPSGELVTGS 164
Cdd:cd00200    74 TIRLWDLETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDGTFVASS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 165 S-DATLKLWRGKS--CLKTFSGHTDTVRSLSVMSDLG-VLSASHDGSIRLWALS-GQTLMEMVGHTSIVYSVDSHASG-L 238
Cdd:cd00200   154 SqDGTIKLWDLRTgkCVATLTGHTGEVNSVAFSPDGEkLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFSPDGyL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2047916283 239 IVSGSEDCSAKIW--KDGICVQSIE-HPGCVWDAKFLENG-DIVTACSDGVLRVW 289
Cdd:cd00200   234 LASGSEDGTIRVWdlRTGECVQTLSgHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 336-446 6.09e-54

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


:

Pssm-ID: 462670  Cd Length: 111  Bit Score: 181.18  E-value: 6.09e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 336 PGTSNGQTKVIREGDNGV-AYSWNSKDYKWDKIGEVVDGPDDSRgKPVLDGAEYDFVFDVDIGDGEPIRKLPYNLSDDPY 414
Cdd:pfam09070   1 PGKKEGQVKMVREGNGVVeAYQWSAAEQQWEKIGDVVGSAGSSQ-KKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGDNPY 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2047916283 415 TTADNWLLKENLPLVYRQQVVDFILQNSGKTN 446
Cdd:pfam09070  80 EAAQKFLARNELPQSYLDQVVNFIIKNTGGVT 111
 
Name Accession Description Interval E-value
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 484-748 6.74e-60

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


Pssm-ID: 462428  Cd Length: 261  Bit Score: 202.95  E-value: 6.74e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 484 PKKGALVFDVAQFDGILKKIVEFNNGlladsDKKNYALPEIEVSRLGTLVKILKDTSHYHstkftDADVALLLNLLRSWP 563
Cdd:pfam08324   1 PQKTYLSFKKANLDKILKKLGEFNGG-----EPKVLALSPEELATLEALLSFLESSSSAS-----EADIELLLKILTSWP 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 564 CELLFPVIDTLRMTVLHPDGAIMLLKLVDSDdILLELIQKVTTPPAiGANLLTSIRLIANLFKNSGYYDWLQKRRSEIID 643
Cdd:pfam08324  71 PEDRFPALDLLRLLALDPRVAAYFAEEEGGK-TISTLLSLLISSGL-YALRMLALRLLCNLFSSPLGRQLLLSHFDSILS 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 644 AYSSCYSTA----NKAVQLSFSTLILNYAVLLI---EKKDFDGQCQVLSAAIEIAEEESLEADSKFRALVAIGSLMIEGG 716
Cdd:pfam08324 149 TLASLLSSSlldsNKNLRIALATLLLNYAVLLHkekSPLSEEDQVELLAALLEALSTEEEDSEALYRLLVALGTLVYAPD 228

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2047916283 717 DDMKRTAL-DFDVKSIARKASASKDAKIAEVGA 748
Cdd:pfam08324 229 GEVLADLAqVLDAASWVKKAKKKKEPRIKEVGS 261
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-289 1.20e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 203.34  E-value: 1.20e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  10 LRCELTGHEDDVRGICVCGNVG-IATSSRDRTVRFWNLDGRKYEQSkiLLGHTSFVGPLAWISPDEQypegrIVSGGMDT 88
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRT--LKGHTGPVRDVAASADGTY-----LASGSSDK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  89 FVFVWDLRTGERVQTLKGHQQQVTGIALDSGD--IVSSSVDCTLRRW--RNGQVVEFWGAHNAAIQSVIKLPSGELVTGS 164
Cdd:cd00200    74 TIRLWDLETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDGTFVASS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 165 S-DATLKLWRGKS--CLKTFSGHTDTVRSLSVMSDLG-VLSASHDGSIRLWALS-GQTLMEMVGHTSIVYSVDSHASG-L 238
Cdd:cd00200   154 SqDGTIKLWDLRTgkCVATLTGHTGEVNSVAFSPDGEkLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFSPDGyL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2047916283 239 IVSGSEDCSAKIW--KDGICVQSIE-HPGCVWDAKFLENG-DIVTACSDGVLRVW 289
Cdd:cd00200   234 LASGSEDGTIRVWdlRTGECVQTLSgHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
9-292 9.55e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 196.67  E-value: 9.55e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283   9 KLRCELTGHEDDVRGICV--CGNVgIATSSRDRTVRFWNLDGRKyeQSKILLGHTSFVGPLAWiSPDEQypegRIVSGGM 86
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFspDGKT-LASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAF-SPDGK----LLASGSD 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  87 DTFVFVWDLRTGERVQTLKGHQQQVTGIAL--DSGDIVSSSVDCTLRRW--RNGQVVEFWGAHNAAIQSVIKLPSGE-LV 161
Cdd:COG2319   183 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWdlATGKLLRTLTGHSGSVRSVAFSPDGRlLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 162 TGSSDATLKLWR--GKSCLKTFSGHTDTVRSLSVMSDlG--VLSASHDGSIRLWAL-SGQTLMEMVGHTSIVYSVDSHAS 236
Cdd:COG2319   263 SGSADGTVRLWDlaTGELLRTLTGHSGGVNSVAFSPD-GklLASGSDDGTVRLWDLaTGKLLRTLTGHTGAVRSVAFSPD 341

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2047916283 237 G-LIVSGSEDCSAKIW--KDGICVQSIE-HPGCVWDAKFLENGD-IVTACSDGVLRVWTAD 292
Cdd:COG2319   342 GkTLASGSDDGTVRLWdlATGELLRTLTgHTGAVTSVAFSPDGRtLASGSADGTVRLWDLA 402
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 336-446 6.09e-54

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


Pssm-ID: 462670  Cd Length: 111  Bit Score: 181.18  E-value: 6.09e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 336 PGTSNGQTKVIREGDNGV-AYSWNSKDYKWDKIGEVVDGPDDSRgKPVLDGAEYDFVFDVDIGDGEPIRKLPYNLSDDPY 414
Cdd:pfam09070   1 PGKKEGQVKMVREGNGVVeAYQWSAAEQQWEKIGDVVGSAGSSQ-KKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGDNPY 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2047916283 415 TTADNWLLKENLPLVYRQQVVDFILQNSGKTN 446
Cdd:pfam09070  80 EAAQKFLARNELPQSYLDQVVNFIIKNTGGVT 111
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 47-244 8.27e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 68.96  E-value: 8.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  47 DGRKYEQSKILLGHTSFVGPLAWISpdeqYPEGRIVSGGMDTFVFVWDLRTGERVQTLKGHQQQVTGIALDSGD---IVS 123
Cdd:PLN00181  518 DGRDIHYPVVELASRSKLSGICWNS----YIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADptlLAS 593

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 124 SSVDCTLRRWRNGQVVEFWGAHNAAIQSVIKLPSG---ELVTGSSDATL---KLWRGKSCLKTFSGHTDTVRSLSVMSDL 197
Cdd:PLN00181  594 GSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSEsgrSLAFGSADHKVyyyDLRNPKLPLCTMIGHSKTVSYVRFVDSS 673

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2047916283 198 GVLSASHDGSIRLWALSGQT-------LMEMVGHTSIVYSVD-SHASGLIVSGSE 244
Cdd:PLN00181  674 TLVSSSTDNTLKLWDLSMSIsginetpLHSFMGHTNVKNFVGlSVSDGYIATGSE 728
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-211 9.74e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 9.74e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2047916283  175 KSCLKTFSGHTDTVRSLSVMSDLGVL-SASHDGSIRLW 211
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLaSGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
175-211 2.74e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 2.74e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2047916283 175 KSCLKTFSGHTDTVRSLSVMSDLG-VLSASHDGSIRLW 211
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 484-748 6.74e-60

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


Pssm-ID: 462428  Cd Length: 261  Bit Score: 202.95  E-value: 6.74e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 484 PKKGALVFDVAQFDGILKKIVEFNNGlladsDKKNYALPEIEVSRLGTLVKILKDTSHYHstkftDADVALLLNLLRSWP 563
Cdd:pfam08324   1 PQKTYLSFKKANLDKILKKLGEFNGG-----EPKVLALSPEELATLEALLSFLESSSSAS-----EADIELLLKILTSWP 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 564 CELLFPVIDTLRMTVLHPDGAIMLLKLVDSDdILLELIQKVTTPPAiGANLLTSIRLIANLFKNSGYYDWLQKRRSEIID 643
Cdd:pfam08324  71 PEDRFPALDLLRLLALDPRVAAYFAEEEGGK-TISTLLSLLISSGL-YALRMLALRLLCNLFSSPLGRQLLLSHFDSILS 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 644 AYSSCYSTA----NKAVQLSFSTLILNYAVLLI---EKKDFDGQCQVLSAAIEIAEEESLEADSKFRALVAIGSLMIEGG 716
Cdd:pfam08324 149 TLASLLSSSlldsNKNLRIALATLLLNYAVLLHkekSPLSEEDQVELLAALLEALSTEEEDSEALYRLLVALGTLVYAPD 228

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2047916283 717 DDMKRTAL-DFDVKSIARKASASKDAKIAEVGA 748
Cdd:pfam08324 229 GEVLADLAqVLDAASWVKKAKKKKEPRIKEVGS 261
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-289 1.20e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 203.34  E-value: 1.20e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  10 LRCELTGHEDDVRGICVCGNVG-IATSSRDRTVRFWNLDGRKYEQSkiLLGHTSFVGPLAWISPDEQypegrIVSGGMDT 88
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRT--LKGHTGPVRDVAASADGTY-----LASGSSDK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  89 FVFVWDLRTGERVQTLKGHQQQVTGIALDSGD--IVSSSVDCTLRRW--RNGQVVEFWGAHNAAIQSVIKLPSGELVTGS 164
Cdd:cd00200    74 TIRLWDLETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDGTFVASS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 165 S-DATLKLWRGKS--CLKTFSGHTDTVRSLSVMSDLG-VLSASHDGSIRLWALS-GQTLMEMVGHTSIVYSVDSHASG-L 238
Cdd:cd00200   154 SqDGTIKLWDLRTgkCVATLTGHTGEVNSVAFSPDGEkLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFSPDGyL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2047916283 239 IVSGSEDCSAKIW--KDGICVQSIE-HPGCVWDAKFLENG-DIVTACSDGVLRVW 289
Cdd:cd00200   234 LASGSEDGTIRVWdlRTGECVQTLSgHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
9-292 9.55e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 196.67  E-value: 9.55e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283   9 KLRCELTGHEDDVRGICV--CGNVgIATSSRDRTVRFWNLDGRKyeQSKILLGHTSFVGPLAWiSPDEQypegRIVSGGM 86
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFspDGKT-LASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAF-SPDGK----LLASGSD 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  87 DTFVFVWDLRTGERVQTLKGHQQQVTGIAL--DSGDIVSSSVDCTLRRW--RNGQVVEFWGAHNAAIQSVIKLPSGE-LV 161
Cdd:COG2319   183 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWdlATGKLLRTLTGHSGSVRSVAFSPDGRlLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 162 TGSSDATLKLWR--GKSCLKTFSGHTDTVRSLSVMSDlG--VLSASHDGSIRLWAL-SGQTLMEMVGHTSIVYSVDSHAS 236
Cdd:COG2319   263 SGSADGTVRLWDlaTGELLRTLTGHSGGVNSVAFSPD-GklLASGSDDGTVRLWDLaTGKLLRTLTGHTGAVRSVAFSPD 341

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2047916283 237 G-LIVSGSEDCSAKIW--KDGICVQSIE-HPGCVWDAKFLENGD-IVTACSDGVLRVWTAD 292
Cdd:COG2319   342 GkTLASGSDDGTVRLWdlATGELLRTLTgHTGAVTSVAFSPDGRtLASGSADGTVRLWDLA 402
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 336-446 6.09e-54

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


Pssm-ID: 462670  Cd Length: 111  Bit Score: 181.18  E-value: 6.09e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 336 PGTSNGQTKVIREGDNGV-AYSWNSKDYKWDKIGEVVDGPDDSRgKPVLDGAEYDFVFDVDIGDGEPIRKLPYNLSDDPY 414
Cdd:pfam09070   1 PGKKEGQVKMVREGNGVVeAYQWSAAEQQWEKIGDVVGSAGSSQ-KKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGDNPY 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2047916283 415 TTADNWLLKENLPLVYRQQVVDFILQNSGKTN 446
Cdd:pfam09070  80 EAAQKFLARNELPQSYLDQVVNFIIKNTGGVT 111
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-252 1.04e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.76  E-value: 1.04e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283   4 NSNDYKLRCELTGHEDDVRGI-CVCGNVGIATSSRDRTVRFWNLDGRkyEQSKILLGHTSFVGPLAWiSPDEQYpegrIV 82
Cdd:cd00200    37 DLETGELLRTLKGHTGPVRDVaASADGTYLASGSSDKTIRLWDLETG--ECVRTLTGHTSYVSSVAF-SPDGRI----LS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  83 SGGMDTFVFVWDLRTGERVQTLKGHQQQVTGIALDSGD--IVSSSVDCTLRRW--RNGQVVEFWGAHNAAIQSVIKLPSG 158
Cdd:cd00200   110 SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDG 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 159 E-LVTGSSDATLKLW--RGKSCLKTFSGHTDTVRSLSVMSDLG-VLSASHDGSIRLW-ALSGQTLMEMVGHTSIVYSVDS 233
Cdd:cd00200   190 EkLLSSSSDGTIKLWdlSTGKCLGTLRGHENGVNSVAFSPDGYlLASGSEDGTIRVWdLRTGECVQTLSGHTNSVTSLAW 269

                         250       260
                  ....*....|....*....|
gi 2047916283 234 HASG-LIVSGSEDCSAKIWK 252
Cdd:cd00200   270 SPDGkRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
4-251 9.93e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 182.80  E-value: 9.93e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283   4 NSNDYKLRCELTGHEDDVRGICVCGNvG--IATSSRDRTVRFWNLDGRKyeQSKILLGHTSFVGPLAWiSPDEQypegRI 81
Cdd:COG2319   148 DLATGKLLRTLTGHSGAVTSVAFSPD-GklLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAF-SPDGK----LL 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  82 VSGGMDTFVFVWDLRTGERVQTLKGHQQQVTGIALdSGD---IVSSSVDCTLRRWR--NGQVVEFWGAHNAAIQSVIKLP 156
Cdd:COG2319   220 ASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF-SPDgrlLASGSADGTVRLWDlaTGELLRTLTGHSGGVNSVAFSP 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 157 SGE-LVTGSSDATLKLWRGKS--CLKTFSGHTDTVRSLSVMSDlG--VLSASHDGSIRLWAL-SGQTLMEMVGHTSIVYS 230
Cdd:COG2319   299 DGKlLASGSDDGTVRLWDLATgkLLRTLTGHTGAVRSVAFSPD-GktLASGSDDGTVRLWDLaTGELLRTLTGHTGAVTS 377

                         250       260
                  ....*....|....*....|..
gi 2047916283 231 VDSHASG-LIVSGSEDCSAKIW 251
Cdd:COG2319   378 VAFSPDGrTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
14-292 1.86e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 182.03  E-value: 1.86e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  14 LTGHEDDVRGICV-CGNVGIATSSRDRTVRFWNLDGRkyEQSKILLGHTSFVGPLAWiSPDEQypegRIVSGGMDTFVFV 92
Cdd:COG2319    74 LLGHTAAVLSVAFsPDGRLLASASADGTVRLWDLATG--LLLRTLTGHTGAVRSVAF-SPDGK----TLASGSADGTVRL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  93 WDLRTGERVQTLKGHQQQVTGIALdSGD---IVSSSVDCTLRRW--RNGQVVEFWGAHNAAIQSVIKLPSGE-LVTGSSD 166
Cdd:COG2319   147 WDLATGKLLRTLTGHSGAVTSVAF-SPDgklLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKlLASGSAD 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 167 ATLKLW--RGKSCLKTFSGHTDTVRSLSVMSDlG--VLSASHDGSIRLWAL-SGQTLMEMVGHTSIVYSVDSHASG-LIV 240
Cdd:COG2319   226 GTVRLWdlATGKLLRTLTGHSGSVRSVAFSPD-GrlLASGSADGTVRLWDLaTGELLRTLTGHSGGVNSVAFSPDGkLLA 304

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2047916283 241 SGSEDCSAKIW--KDGICVQSIE-HPGCVWDAKFLENGD-IVTACSDGVLRVWTAD 292
Cdd:COG2319   305 SGSDDGTVRLWdlATGKLLRTLTgHTGAVRSVAFSPDGKtLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
9-215 4.56e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.45  E-value: 4.56e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283   9 KLRCELTGHEDDVRGICVC--GNVgIATSSRDRTVRFWNLDGRKyeQSKILLGHTSFVGPLAWiSPDEQypegRIVSGGM 86
Cdd:COG2319   195 KLLRTLTGHTGAVRSVAFSpdGKL-LASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSVAF-SPDGR----LLASGSA 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  87 DTFVFVWDLRTGERVQTLKGHQQQVTGIAL--DSGDIVSSSVDCTLRRW--RNGQVVEFWGAHNAAIQSVIKLPSGE-LV 161
Cdd:COG2319   267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKtLA 346

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2047916283 162 TGSSDATLKLW--RGKSCLKTFSGHTDTVRSLSVMSDlG--VLSASHDGSIRLWALSG 215
Cdd:COG2319   347 SGSDDGTVRLWdlATGELLRTLTGHTGAVTSVAFSPD-GrtLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
31-292 1.47e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 139.28  E-value: 1.47e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  31 GIATSSRDRTVRFWNLDGRkyEQSKILLGHTSFVGPLAWISPDeqypeGRIVSGGMDTFVFVWDLRTGERVQTLKGHQQQ 110
Cdd:COG2319     8 ALAAASADLALALLAAALG--ALLLLLLGLAAAVASLAASPDG-----ARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 111 VTGIALDSGD--IVSSSVDCTLRRWR--NGQVVEFWGAHNAAIQSVIKLPSGE-LVTGSSDATLKLWRGKS--CLKTFSG 183
Cdd:COG2319    81 VLSVAFSPDGrlLASASADGTVRLWDlaTGLLLRTLTGHTGAVRSVAFSPDGKtLASGSADGTVRLWDLATgkLLRTLTG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 184 HTDTVRSLSVMSDlG--VLSASHDGSIRLW-ALSGQTLMEMVGHTSIVYSVDSHASG-LIVSGSEDCSAKIW--KDGICV 257
Cdd:COG2319   161 HSGAVTSVAFSPD-GklLASGSDDGTVRLWdLATGKLLRTLTGHTGAVRSVAFSPDGkLLASGSADGTVRLWdlATGKLL 239

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2047916283 258 QSIE-HPGCVWDAKFLENGD-IVTACSDGVLRVWTAD 292
Cdd:COG2319   240 RTLTgHSGSVRSVAFSPDGRlLASGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
80-296 2.76e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 2.76e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  80 RIVSGGMDTFVFVWDLRTGERVQTLKGHQQQVTGIAL--DSGDIVSSSVDCTLRRWRN--GQVVEFWGAHNAAIQSVIKL 155
Cdd:COG2319     8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAAspDGARLAAGAGDLTLLLLDAaaGALLATLLGHTAAVLSVAFS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 156 PSGE-LVTGSSDATLKLWR--GKSCLKTFSGHTDTVRSLSVMSDlG--VLSASHDGSIRLW-ALSGQTLMEMVGHTSIVY 229
Cdd:COG2319    88 PDGRlLASASADGTVRLWDlaTGLLLRTLTGHTGAVRSVAFSPD-GktLASGSADGTVRLWdLATGKLLRTLTGHSGAVT 166

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2047916283 230 SVDSHASG-LIVSGSEDCSAKIW--KDGICVQSIE-HPGCVWDAKFLENGD-IVTACSDGVLRVWTADQERI 296
Cdd:COG2319   167 SVAFSPDGkLLASGSDDGTVRLWdlATGKLLRTLTgHTGAVRSVAFSPDGKlLASGSADGTVRLWDLATGKL 238
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 47-244 8.27e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 68.96  E-value: 8.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  47 DGRKYEQSKILLGHTSFVGPLAWISpdeqYPEGRIVSGGMDTFVFVWDLRTGERVQTLKGHQQQVTGIALDSGD---IVS 123
Cdd:PLN00181  518 DGRDIHYPVVELASRSKLSGICWNS----YIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADptlLAS 593

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283 124 SSVDCTLRRWRNGQVVEFWGAHNAAIQSVIKLPSG---ELVTGSSDATL---KLWRGKSCLKTFSGHTDTVRSLSVMSDL 197
Cdd:PLN00181  594 GSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSEsgrSLAFGSADHKVyyyDLRNPKLPLCTMIGHSKTVSYVRFVDSS 673

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2047916283 198 GVLSASHDGSIRLWALSGQT-------LMEMVGHTSIVYSVD-SHASGLIVSGSE 244
Cdd:PLN00181  674 TLVSSSTDNTLKLWDLSMSIsginetpLHSFMGHTNVKNFVGlSVSDGYIATGSE 728
PTZ00421 PTZ00421
coronin; Provisional
 34-148 4.18e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.89  E-value: 4.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047916283  34 TSSRDRTVRFWNL--DGRKYEQSKILL---GHTSFVGPLAWispdeqYPE--GRIVSGGMDTFVFVWDLRTGERVQTLKG 106
Cdd:PTZ00421   93 TASEDGTIMGWGIpeEGLTQNISDPIVhlqGHTKKVGIVSF------HPSamNVLASAGADMVVNVWDVERGKAVEVIKC 166

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2047916283 107 HQQQVTGIA--LDSGDIVSSSVDCTLRRW--RNGQVVEFWGAHNAA 148
Cdd:PTZ00421  167 HSDQITSLEwnLDGSLLCTTSKDKKLNIIdpRDGTIVSSVEAHASA 212
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-211 9.74e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 9.74e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2047916283  175 KSCLKTFSGHTDTVRSLSVMSDLGVL-SASHDGSIRLW 211
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLaSGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
175-211 2.74e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 2.74e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2047916283 175 KSCLKTFSGHTDTVRSLSVMSDLG-VLSASHDGSIRLW 211
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
215-251 8.01e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 8.01e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2047916283 215 GQTLMEMVGHTSIVYSVDSHASG-LIVSGSEDCSAKIW 251
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 214-252 1.99e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.99e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2047916283  214 SGQTLMEMVGHTSIVYSVDSHASG-LIVSGSEDCSAKIWK 252
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 9-45 6.87e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 6.87e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2047916283    9 KLRCELTGHEDDVRGICVCGNVG-IATSSRDRTVRFWN 45
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKyLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 97-133 2.03e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 2.03e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2047916283   97 TGERVQTLKGHQQQVTGIALDSGD--IVSSSVDCTLRRW 133
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkyLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
98-133 7.34e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 7.34e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2047916283  98 GERVQTLKGHQQQVTGIALDSGD--IVSSSVDCTLRRW 133
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGklLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
9-45 9.03e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 9.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2047916283   9 KLRCELTGHEDDVRGICVCGNVG-IATSSRDRTVRFWN 45
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 253-289 9.83e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 9.83e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2047916283  253 DGICVQSIE-HPGCVWDAKFLENGD-IVTACSDGVLRVW 289
Cdd:smart00320   1 SGELLKTLKgHTGPVTSVAFSPDGKyLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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