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Conserved domains on  [gi|2047897684|gb|KAG6571705|]
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Microspherule protein 1, partial [Cucurbita argyrosperma subsp. sororia]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FHA_MCRS1 cd22687
forkhead associated (FHA) domain found in microspherule protein 1 (MCRS1) and similar proteins; ...
 752-856 5.01e-44

forkhead associated (FHA) domain found in microspherule protein 1 (MCRS1) and similar proteins; MCRS1, also called 58 kDa microspherule protein (MSP58), cell cycle-regulated factor p78, or INO80 complex subunit J, is a nuclear RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal ribonucleoparticles (mRNPs) from neurons. It is a cell-cycle-dependent protein that acts as an inhibitor of TERT telomerase activity. It associates with LPTS/PinX1 and reduces the telomere length. It modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex, MCRS1 may be involved in acetylation of nucleosomal histone H4 on several lysine residues. MCRS1 is also a putative regulatory component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication, and probably DNA repair. MCRS1 contains an FHA domain at its C-terminus. The FHA domain is a small phosphopeptide recognition module.


:

Pssm-ID: 438739 [Multi-domain]  Cd Length: 105  Bit Score: 154.63  E-value: 5.01e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047897684 752 ASHGALAVLYGRYSKHYIKKSEVLLGRATEDVIVDIDLGREGSGNKISRRQAIIKLDQDGFFSLKNLGKCSISINNKDVA 831
Cdd:cd22687     1 FDSGALAVLRGRLVRYLMRSREVTIGRSTKDNQVDIDLSLEGPAWKISRRQAVIKLKNDGDFYIKNEGKRPIYVNGKPVP 80

                          90       100
                  ....*....|....*....|....*
gi 2047897684 832 PGHCLRLNSGCLIEIRGMPFIFESN 856
Cdd:cd22687    81 TGEKAILNNNSLIEIGGLRFVFLIN 105
MCRS_N super family cl20488
N-terminal region of micro-spherule protein; This domain is found in plants and higher ...
 10-68 1.73e-15

N-terminal region of micro-spherule protein; This domain is found in plants and higher eukaryotes, and is the N-terminal region of micro-spherule proteins which repress the transactivation activities of Nrf1 (p45 nuclear factor-erythroid 2 (p45 NF-E2)-related factor 1). In conjunction with DIPA the full-length protein acts as a transcription repressor. The exact function of the region is not known.


The actual alignment was detected with superfamily member pfam13325:

Pssm-ID: 463845  Cd Length: 199  Bit Score: 76.17  E-value: 1.73e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2047897684  10 WTPEDDILLKNAVEAGASLESLAKGaVQFSRRYTVRELQERWHSLLYDPIVSEDASMSM 68
Cdd:pfam13325   2 WKPTDDLALITAVQQTNDLRAVHRG-VKFSCRFTLQEIQERWYALLYDPTISRIAVAAM 59
 
Name Accession Description Interval E-value
FHA_MCRS1 cd22687
forkhead associated (FHA) domain found in microspherule protein 1 (MCRS1) and similar proteins; ...
 752-856 5.01e-44

forkhead associated (FHA) domain found in microspherule protein 1 (MCRS1) and similar proteins; MCRS1, also called 58 kDa microspherule protein (MSP58), cell cycle-regulated factor p78, or INO80 complex subunit J, is a nuclear RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal ribonucleoparticles (mRNPs) from neurons. It is a cell-cycle-dependent protein that acts as an inhibitor of TERT telomerase activity. It associates with LPTS/PinX1 and reduces the telomere length. It modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex, MCRS1 may be involved in acetylation of nucleosomal histone H4 on several lysine residues. MCRS1 is also a putative regulatory component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication, and probably DNA repair. MCRS1 contains an FHA domain at its C-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438739 [Multi-domain]  Cd Length: 105  Bit Score: 154.63  E-value: 5.01e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047897684 752 ASHGALAVLYGRYSKHYIKKSEVLLGRATEDVIVDIDLGREGSGNKISRRQAIIKLDQDGFFSLKNLGKCSISINNKDVA 831
Cdd:cd22687     1 FDSGALAVLRGRLVRYLMRSREVTIGRSTKDNQVDIDLSLEGPAWKISRRQAVIKLKNDGDFYIKNEGKRPIYVNGKPVP 80

                          90       100
                  ....*....|....*....|....*
gi 2047897684 832 PGHCLRLNSGCLIEIRGMPFIFESN 856
Cdd:cd22687    81 TGEKAILNNNSLIEIGGLRFVFLIN 105
MCRS_N pfam13325
N-terminal region of micro-spherule protein; This domain is found in plants and higher ...
 10-68 1.73e-15

N-terminal region of micro-spherule protein; This domain is found in plants and higher eukaryotes, and is the N-terminal region of micro-spherule proteins which repress the transactivation activities of Nrf1 (p45 nuclear factor-erythroid 2 (p45 NF-E2)-related factor 1). In conjunction with DIPA the full-length protein acts as a transcription repressor. The exact function of the region is not known.


Pssm-ID: 463845  Cd Length: 199  Bit Score: 76.17  E-value: 1.73e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2047897684  10 WTPEDDILLKNAVEAGASLESLAKGaVQFSRRYTVRELQERWHSLLYDPIVSEDASMSM 68
Cdd:pfam13325   2 WKPTDDLALITAVQQTNDLRAVHRG-VKFSCRFTLQEIQERWYALLYDPTISRIAVAAM 59
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 774-846 1.60e-04

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 40.64  E-value: 1.60e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2047897684 774 VLLGRATEdviVDIDLgregSGNKISRRQAIIKLDQDGFFSLKNLGKCS-ISINNKDVAPgHCLRLNSGCLIEI 846
Cdd:pfam00498   1 VTIGRSPD---CDIVL----DDPSVSRRHAEIRYDGGGRFYLEDLGSTNgTFVNGQRLGP-EPVRLKDGDVIRL 66
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 774-830 3.34e-04

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 39.47  E-value: 3.34e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2047897684  774 VLLGRATEDVivDIDLgregSGNKISRRQAIIKLDQDGFFSLKNLG-KCSISINNKDV 830
Cdd:smart00240   1 VTIGRSSEDC--DIQL----DGPSISRRHAVIVYDGGGRFYLIDLGsTNGTFVNGKRI 52
 
Name Accession Description Interval E-value
FHA_MCRS1 cd22687
forkhead associated (FHA) domain found in microspherule protein 1 (MCRS1) and similar proteins; ...
 752-856 5.01e-44

forkhead associated (FHA) domain found in microspherule protein 1 (MCRS1) and similar proteins; MCRS1, also called 58 kDa microspherule protein (MSP58), cell cycle-regulated factor p78, or INO80 complex subunit J, is a nuclear RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal ribonucleoparticles (mRNPs) from neurons. It is a cell-cycle-dependent protein that acts as an inhibitor of TERT telomerase activity. It associates with LPTS/PinX1 and reduces the telomere length. It modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex, MCRS1 may be involved in acetylation of nucleosomal histone H4 on several lysine residues. MCRS1 is also a putative regulatory component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication, and probably DNA repair. MCRS1 contains an FHA domain at its C-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438739 [Multi-domain]  Cd Length: 105  Bit Score: 154.63  E-value: 5.01e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047897684 752 ASHGALAVLYGRYSKHYIKKSEVLLGRATEDVIVDIDLGREGSGNKISRRQAIIKLDQDGFFSLKNLGKCSISINNKDVA 831
Cdd:cd22687     1 FDSGALAVLRGRLVRYLMRSREVTIGRSTKDNQVDIDLSLEGPAWKISRRQAVIKLKNDGDFYIKNEGKRPIYVNGKPVP 80

                          90       100
                  ....*....|....*....|....*
gi 2047897684 832 PGHCLRLNSGCLIEIRGMPFIFESN 856
Cdd:cd22687    81 TGEKAILNNNSLIEIGGLRFVFLIN 105
MCRS_N pfam13325
N-terminal region of micro-spherule protein; This domain is found in plants and higher ...
 10-68 1.73e-15

N-terminal region of micro-spherule protein; This domain is found in plants and higher eukaryotes, and is the N-terminal region of micro-spherule proteins which repress the transactivation activities of Nrf1 (p45 nuclear factor-erythroid 2 (p45 NF-E2)-related factor 1). In conjunction with DIPA the full-length protein acts as a transcription repressor. The exact function of the region is not known.


Pssm-ID: 463845  Cd Length: 199  Bit Score: 76.17  E-value: 1.73e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2047897684  10 WTPEDDILLKNAVEAGASLESLAKGaVQFSRRYTVRELQERWHSLLYDPIVSEDASMSM 68
Cdd:pfam13325   2 WKPTDDLALITAVQQTNDLRAVHRG-VKFSCRFTLQEIQERWYALLYDPTISRIAVAAM 59
FHA_FKH1-like cd22701
forkhead associated (FHA) domain found in Saccharomyces cerevisiae fork head protein homolog 1 ...
 756-853 7.79e-14

forkhead associated (FHA) domain found in Saccharomyces cerevisiae fork head protein homolog 1 (FKH1), 2 (FKH2) and similar proteins; This family includes FKH1 and FKH2, as well as pre-rRNA-processing protein FHL1. FKH1 and FKH2 are forkhead transcription factors that regulate the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle. The CLB2 cluster of genes includes mitotic regulators such as CLB1, CLB2, CDC5 and CDC20, as well as SWI5 and ACE2. FKH1 and FKH2 are involved in HMRa silencing. They associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination, and coordinate early transcription elongation and pre-mRNA processing. Both FKH1 and FKH2 play a role as regulators of lifespan in collaboration with the anaphase-promoting complex (APC), likely through combined regulation of stress response, genomic stability, and cell cycle regulation. They also function in controlling yeast cell morphology by preventing pseudohyphal growth and act as rate-limiting replication origin activators via their interaction with the origin recognition complex (ORC). FHL1 is a forkhead protein that controls the pre-rRNA processing machinery in conjunction with IFH1. It might act as a transcriptional regulator of genes specifically involved in that process. IFH1 convert FHL1 from a repressor to an activator. This family also includes AtFHA1 and AtFHA2, which may play a role in the control of plant organ development. AtFHA2 is specifically involved in the regulation of stamen development. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438753 [Multi-domain]  Cd Length: 106  Bit Score: 68.42  E-value: 7.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047897684 756 ALAVLYGRYSKHYIKKSEVLLGRATED------VIVDIDLGregSGNKISRRQAIIKLD-QDGFFSLKNLGKCSISINNK 828
Cdd:cd22701     1 AYAKLDGDDFTYYVQKLEVVLGRNSKNssstaaDSVDIDLG---PSKKISRRHARIFYDfTTQCFELSVLGRNGVKVDGI 77

                          90       100
                  ....*....|....*....|....*.
gi 2047897684 829 DVAPG-HCLRLNSGCLIEIRGMPFIF 853
Cdd:cd22701    78 LVKPGsPPVPLRSGSLIQIGGVLFYF 103
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 765-854 6.92e-07

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 48.04  E-value: 6.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2047897684 765 SKHYIKKSEVLLGRATEDVIVDIDLGregsgnkISRRQAIIKLDQDGFFsLKNLG-KCSISINNKDVAPGHclRLNSGCL 843
Cdd:cd00060    12 REFPLTKGVVTIGRSPDCDIVLDDPS-------VSRRHARIEVDGGGVY-LEDLGsTNGTFVNGKRITPPV--PLQDGDV 81

                          90
                  ....*....|.
gi 2047897684 844 IEIRGMPFIFE 854
Cdd:cd00060    82 IRLGDTTFRFE 92
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 774-846 1.60e-04

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 40.64  E-value: 1.60e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2047897684 774 VLLGRATEdviVDIDLgregSGNKISRRQAIIKLDQDGFFSLKNLGKCS-ISINNKDVAPgHCLRLNSGCLIEI 846
Cdd:pfam00498   1 VTIGRSPD---CDIVL----DDPSVSRRHAEIRYDGGGRFYLEDLGSTNgTFVNGQRLGP-EPVRLKDGDVIRL 66
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 774-830 3.34e-04

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 39.47  E-value: 3.34e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2047897684  774 VLLGRATEDVivDIDLgregSGNKISRRQAIIKLDQDGFFSLKNLG-KCSISINNKDV 830
Cdd:smart00240   1 VTIGRSSEDC--DIQL----DGPSISRRHAVIVYDGGGRFYLIDLGsTNGTFVNGKRI 52
FHA_FOXK cd22688
forkhead associated (FHA) domain found in the Forkhead box protein K (FOXK) subfamily; The ...
 756-820 5.92e-03

forkhead associated (FHA) domain found in the Forkhead box protein K (FOXK) subfamily; The FOXK subfamily includes two-winged helix transcription factors, FOXK1 and FOXK2. FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The Forkhead (FH) domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438740 [Multi-domain]  Cd Length: 100  Bit Score: 37.25  E-value: 5.92e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2047897684 756 ALAVLYGRYSKHYIKKSEVLLGRATEDVIVDIDLGRegsGNKISRRQAIIKLDqDGFFSLKNLGK 820
Cdd:cd22688     3 AIARLEGREFEYLMRKSRVVIGRNSSRGPVDVNMGH---SSFISRKHLEIFYE-GGRFFLLCNGK 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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