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Conserved domains on  [gi|1958730177|gb|KAG1957597|]
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Nucleotide Sugar TransPorter family [Pimephales promelas]

Protein Classification

DMT family transporter( domain architecture ID 12093821)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others; such as yeast UDP-N-acetylglucosamine transporter YEA4 and vertebrate UDP-xylose and UDP-N-acetylglucosamine transporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
2-314 2.33e-128

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


:

Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 368.93  E-value: 2.33e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958730177   2 NTLFATSLVFVGCCSNVVFLELLVRDFPGC-GNIVTFAQFAFIALEGF----IFETNFGRKKPHIPLSNYVIMVTMFFTV 76
Cdd:pfam08449   1 QFLLAVSGVFGGCCSNGVLQELIMKVEPGPfGNLLTFAQFLFYALEGLpesiDIFTSKFLKPRKIPLKTYVILVALFFIT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958730177  77 SVINNYALNFNIAMPLHMIFRSGSLIANMVLGIVILKKRYSMSKYLSIALVSLGIFICTIMSAKQVsvekgatEEDGVYA 156
Cdd:pfam08449  81 SVLNNEALKYDISYPTHIIFRSSKLIPVMIMGILILGKRYSKLQYLSAFLVTLGIIIFTLFSAKDK-------VADSVVS 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958730177 157 FMHWLLGIAMLTFALLMSARMGIFQETLYKKYGKHSKEALFYNHCLPLPGFLLLSTDIYKHAVLFSQSSPVEIPvigqSM 236
Cdd:pfam08449 154 PNFFLIGIAMLSGALLLDAFLGNYQEKTYKKYGKHSKEMLFYSHLLSLPFFLLLQGDLFSAVQFCSQSPDKAVL----SL 229
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958730177 237 PVMWFYLLMNVITQYVCIRGVFILTTECASLTVTLVVTLRKFLSLIISILYFRNPFTTWHWVGTAVVFLGTLLYTEVW 314
Cdd:pfam08449 230 PSMLFYLLLNVLTQYVCIRGVFILISEFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYSK 307
 
Name Accession Description Interval E-value
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
2-314 2.33e-128

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 368.93  E-value: 2.33e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958730177   2 NTLFATSLVFVGCCSNVVFLELLVRDFPGC-GNIVTFAQFAFIALEGF----IFETNFGRKKPHIPLSNYVIMVTMFFTV 76
Cdd:pfam08449   1 QFLLAVSGVFGGCCSNGVLQELIMKVEPGPfGNLLTFAQFLFYALEGLpesiDIFTSKFLKPRKIPLKTYVILVALFFIT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958730177  77 SVINNYALNFNIAMPLHMIFRSGSLIANMVLGIVILKKRYSMSKYLSIALVSLGIFICTIMSAKQVsvekgatEEDGVYA 156
Cdd:pfam08449  81 SVLNNEALKYDISYPTHIIFRSSKLIPVMIMGILILGKRYSKLQYLSAFLVTLGIIIFTLFSAKDK-------VADSVVS 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958730177 157 FMHWLLGIAMLTFALLMSARMGIFQETLYKKYGKHSKEALFYNHCLPLPGFLLLSTDIYKHAVLFSQSSPVEIPvigqSM 236
Cdd:pfam08449 154 PNFFLIGIAMLSGALLLDAFLGNYQEKTYKKYGKHSKEMLFYSHLLSLPFFLLLQGDLFSAVQFCSQSPDKAVL----SL 229
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958730177 237 PVMWFYLLMNVITQYVCIRGVFILTTECASLTVTLVVTLRKFLSLIISILYFRNPFTTWHWVGTAVVFLGTLLYTEVW 314
Cdd:pfam08449 230 PSMLFYLLLNVLTQYVCIRGVFILISEFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYSK 307
nst TIGR00803
UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10) ...
87-310 2.52e-11

UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10)Nucleotide-sugar transporters (NSTs) are found in the Golgi apparatus and the endoplasmic reticulum of eukaryotic cells. Members of the family have been sequenced from yeast, protozoans and animals. Animals such as C. elegans possess many of these transporters. Humans have at least two closely related isoforms of the UDP-galactose:UMP exchange transporter.NSTs generally appear to function by antiport mechanisms, exchanging a nucleotide-sugar for a nucleotide. Thus, CMP-sialic acid is exchanged for CMP; GDP-mannose is preferentially exchanged for GMP, and UDP-galactose and UDP-N-acetylglucosamine are exchanged for UMP (or possibly UDP). Other nucleotide sugars (e.g., GDP-fucose, UDP-xylose, UDP-glucose, UDP-N-acetylgalactosamine, etc.) may also be transported in exchange for various nucleotides, but their transporters have not been molecularly characterized. Each compound appears to be translocated by its own transport protein. Transport allows the compound, synthesized in the cytoplasm, to be exported to the lumen of the Golgi apparatus or the endoplasmic reticulum where it is used for the synthesis of glycoproteins and glycolipids.


Pssm-ID: 129885  Cd Length: 222  Bit Score: 62.37  E-value: 2.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958730177  87 NIAMPLHMIFRSGSLIANMVLGIVILKKRYSMSKYLSIALVSLGIFICTIMSAKQVSVEKGATEEDGV----YAFMHWLL 162
Cdd:TIGR00803   1 KLSVPIHIIFKQNNLVLIALGNLLAAGKQVTQLKILSTALMTLGSLVASLGDDQWFSLKLLKLGVAIVqmvqSSAKTLMF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958730177 163 GIAMLTFALLMSARMGIFQETLYKKYGKHSKEALFYNHCLPLPGFLLLSTdiYKHAVLFSQSSPVEIPVIGQSMPVMWFY 242
Cdd:TIGR00803  81 GNPVVGLSAVLSALLSSGFAGVYFEKILKDGDTMFWSRNLQLPLFGLFST--FSVLLWSDGTLISNFGFFIGYPTAVWIV 158
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958730177 243 LLMNViTQYVCIRGVFILTTecaSLTVTLVVTLRKFLSLIISILYFRNPFTTWHWVGTAVVFLGTLLY 310
Cdd:TIGR00803 159 GLLNV-GGGLCIGGVVRYAD---NTTKSFVTALSIILSTLASVRLFDAKISSTFYLGAILVFLATFLY 222
 
Name Accession Description Interval E-value
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
2-314 2.33e-128

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 368.93  E-value: 2.33e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958730177   2 NTLFATSLVFVGCCSNVVFLELLVRDFPGC-GNIVTFAQFAFIALEGF----IFETNFGRKKPHIPLSNYVIMVTMFFTV 76
Cdd:pfam08449   1 QFLLAVSGVFGGCCSNGVLQELIMKVEPGPfGNLLTFAQFLFYALEGLpesiDIFTSKFLKPRKIPLKTYVILVALFFIT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958730177  77 SVINNYALNFNIAMPLHMIFRSGSLIANMVLGIVILKKRYSMSKYLSIALVSLGIFICTIMSAKQVsvekgatEEDGVYA 156
Cdd:pfam08449  81 SVLNNEALKYDISYPTHIIFRSSKLIPVMIMGILILGKRYSKLQYLSAFLVTLGIIIFTLFSAKDK-------VADSVVS 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958730177 157 FMHWLLGIAMLTFALLMSARMGIFQETLYKKYGKHSKEALFYNHCLPLPGFLLLSTDIYKHAVLFSQSSPVEIPvigqSM 236
Cdd:pfam08449 154 PNFFLIGIAMLSGALLLDAFLGNYQEKTYKKYGKHSKEMLFYSHLLSLPFFLLLQGDLFSAVQFCSQSPDKAVL----SL 229
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958730177 237 PVMWFYLLMNVITQYVCIRGVFILTTECASLTVTLVVTLRKFLSLIISILYFRNPFTTWHWVGTAVVFLGTLLYTEVW 314
Cdd:pfam08449 230 PSMLFYLLLNVLTQYVCIRGVFILISEFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYSK 307
nst TIGR00803
UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10) ...
87-310 2.52e-11

UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10)Nucleotide-sugar transporters (NSTs) are found in the Golgi apparatus and the endoplasmic reticulum of eukaryotic cells. Members of the family have been sequenced from yeast, protozoans and animals. Animals such as C. elegans possess many of these transporters. Humans have at least two closely related isoforms of the UDP-galactose:UMP exchange transporter.NSTs generally appear to function by antiport mechanisms, exchanging a nucleotide-sugar for a nucleotide. Thus, CMP-sialic acid is exchanged for CMP; GDP-mannose is preferentially exchanged for GMP, and UDP-galactose and UDP-N-acetylglucosamine are exchanged for UMP (or possibly UDP). Other nucleotide sugars (e.g., GDP-fucose, UDP-xylose, UDP-glucose, UDP-N-acetylgalactosamine, etc.) may also be transported in exchange for various nucleotides, but their transporters have not been molecularly characterized. Each compound appears to be translocated by its own transport protein. Transport allows the compound, synthesized in the cytoplasm, to be exported to the lumen of the Golgi apparatus or the endoplasmic reticulum where it is used for the synthesis of glycoproteins and glycolipids.


Pssm-ID: 129885  Cd Length: 222  Bit Score: 62.37  E-value: 2.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958730177  87 NIAMPLHMIFRSGSLIANMVLGIVILKKRYSMSKYLSIALVSLGIFICTIMSAKQVSVEKGATEEDGV----YAFMHWLL 162
Cdd:TIGR00803   1 KLSVPIHIIFKQNNLVLIALGNLLAAGKQVTQLKILSTALMTLGSLVASLGDDQWFSLKLLKLGVAIVqmvqSSAKTLMF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958730177 163 GIAMLTFALLMSARMGIFQETLYKKYGKHSKEALFYNHCLPLPGFLLLSTdiYKHAVLFSQSSPVEIPVIGQSMPVMWFY 242
Cdd:TIGR00803  81 GNPVVGLSAVLSALLSSGFAGVYFEKILKDGDTMFWSRNLQLPLFGLFST--FSVLLWSDGTLISNFGFFIGYPTAVWIV 158
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958730177 243 LLMNViTQYVCIRGVFILTTecaSLTVTLVVTLRKFLSLIISILYFRNPFTTWHWVGTAVVFLGTLLY 310
Cdd:TIGR00803 159 GLLNV-GGGLCIGGVVRYAD---NTTKSFVTALSIILSTLASVRLFDAKISSTFYLGAILVFLATFLY 222
TPT pfam03151
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
35-310 1.35e-04

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


Pssm-ID: 308657 [Multi-domain]  Cd Length: 290  Bit Score: 43.05  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958730177  35 VTFAQFAFIALEGFIFETNFGRKKPHIPLSNYVIMV---TMFFTVSVINNYALNfNIAMPLHMIFRSGSLIANMVLGIVI 111
Cdd:pfam03151  34 VSSVQLFVGSVYILVLWGTGLRKRPKISSPFLKNILplaLCHTLGHVLANVSLG-KVAVSFTHTVKAMEPFFTVILSRLF 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958730177 112 LKKRYSMSKYLSIALVSLGIFICTImsakqvsvekgaTEedgvyafmhwlLGIAMLTFALLMSARMG-IFQETLYKKY-- 188
Cdd:pfam03151 113 LGEYPPLLVYLSLLPIVGGVALASV------------TE-----------LSFNWIGFISAMISNLGfSLRNIFSKKLmk 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958730177 189 GKHSKEALFYNHCLPLPGFLLLStdiykhAVLFSQSSPVEIPVIGQSMPVMWFYLLMNVITQYVCIRGVFILTTECASLT 268
Cdd:pfam03151 170 GKDNLDNLNLFAIITILSLLLLL------PVWLLVEGFKKFPSLLQSGKVGLKDVYMLLLLSGVCFHLYNQVAYMILERV 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1958730177 269 --VTLVV--TLRKFLSLIISILYFRNPFTTWHWVGTAVVFLGTLLY 310
Cdd:pfam03151 244 spVTHSVanTVKRVVVIVSSILVFGNPVSPLNAIGTAIAIAGVFLY 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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