NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1886594609|gb|KAF6404249|]
View 

tectorin alpha [Molossus molossus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
98-254 6.43e-67

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


:

Pssm-ID: 214712  Cd Length: 152  Bit Score: 223.07  E-value: 6.43e-67
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609    98 PFWADVHNGIRGEIYYRETMDPAVLRRATKDIRKYFKDMATFSATWVFIVTWEEVTFYGGSSTTPVNTFQAVLVSDGSYT 177
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDGTNTFQAVLATDGSRT 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1886594609   178 FTLFNYYEINWTTGTASGGDPltglgGVMAQAGFNGGNLTNFFSLPGSRTPDIVNIQETTNVNVPGRWAFKVDGKEI 254
Cdd:smart00539   81 YAIFLYPSLGWTSDTTAGGDD-----GVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 1805-2059 2.98e-60

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


:

Pssm-ID: 214579  Cd Length: 252  Bit Score: 208.01  E-value: 2.98e-60
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1805 TCKASQMEVSISKCKLFQLGFEREGVRVNDRQCTG---IEGEDFISFQINNTKgnCGNIVQSNGTHIMYKNTVWIesANN 1881
Cdd:smart00241    1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPqftDATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLVV--SPF 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1882 TGNIITRDRTINVEFSCAYELDIKISLDSVVKPMLSVINltVPTQEGSFTTKMALYKNASYKHPYRQGEVVLttRDVLYV 1961
Cdd:smart00241   77 HPGFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTEL--SSVSEGPLTCSYRLYKDDSFGSPYQSADYVL--GDPVYH 152

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1962 GVFVVGADATHLILTLNKCYATPSRDSNDKLRYFIIEEGCQ--NIKDNTIGIEENgVSLTCRFHVTVFKFIgDYDEVHLH 2039
Cdd:smart00241  153 EWECDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPvdGYLDSTIPYNSN-PLHRARFSVKVFKFA-DRSLVYFH 230

                           250       260
                    ....*....|....*....|..
gi 1886594609  2040 CAVSLCDSEKYS--CKITCPQN 2059
Cdd:smart00241  231 CQIRLCDKDDGSscDGPACSSR 252
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 313-477 3.73e-46

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 164.11  E-value: 3.73e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609   313 YCSPMET-STCVVFGEPHYHTFDGFLFHFQGSCAYLLARQClqtSSLPFFSVEAKNEHRGGSAvSWVKELSVEVNGYKIL 391
Cdd:smart00216    2 CCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC---SSEPTFSVLLKNVPCGGGA-TCLKSVKVELNGDEIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609   392 IPKGsYGKVKVNDLVTSLPVTLDLGAVKIYQSGMSTAVETDFGLL-VIFDGQHYASISVPGSYTNSTCGLCGNYNKNPLD 470
Cdd:smart00216   78 LKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 1886594609   471 DFLRPDG 477
Cdd:smart00216  157 DFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1100-1258 2.33e-37

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 138.27  E-value: 2.33e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609 1100 CIVSGYGHYLTFDGYPFDFQTSCPLILCTTgdrPSSDAFPKFIVTAKNEDRDpSLALWVKQVDVTMFGYSIVIHRAykHT 1179
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKD---CSEEPDFSFSVTNKNCNGG-ASGVCLKSVTVIVGDLEITLQKG--GT 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609 1180 VLVNNERLYLPLKLGQGKINIFSFGFHVV-VETDFGLKVVYDWKTFLSITVPRSMQNSTSGLCGRYNGHPDDDLEMPMGL 1258
Cdd:pfam00094   75 VLVNGQKVSLPYKSDGGEVEILGSGFVVVdLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1487-1639 9.15e-36

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 134.04  E-value: 9.15e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609 1487 CLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDISFQLIINFDKWSSPNlTIISPVYFYINEEQILINDRNTVKVNG 1566
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASG-VCLKSVTVIVGDLEITLQKGGTVLVNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1886594609 1567 TQVNVPFIT-GLATKIYSSeGFLVIDTSPDIQIHYNGYNV--IKISISERLQNKVCGLCGNFNGDLTDDYVTLRGK 1639
Cdd:pfam00094   80 QKVSLPYKSdGGEVEILGS-GFVVVDLSPGVGLQVDGDGRgqLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 713-866 2.94e-32

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 123.63  E-value: 2.94e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  713 CLLSQNQVLHTFDGAAYAFPSEFSYTLLRTCPEQPEYLEIDINKKKPDGGPAW-LRGLRILVANQEVKLGGVGaaEVKVN 791
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASGVcLKSVTVIVGDLEITLQKGG--TVLVN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1886594609  792 GQEVELPFFHLSGKLEIYRNKNSTTVESRGI-LSVQYSDTGLLYIRLSTVYFNCTGGLCGFFNANASDEFCLPNGK 866
Cdd:pfam00094   79 GQKVSLPYKSDGGEVEILGSGFVVVDLSPGVgLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 517-591 8.36e-24

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 96.64  E-value: 8.36e-24
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609   517 LYFGPDYCGFLNRTDGPLWECGTVVDPTAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRLQTGC 591
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 905-981 7.01e-18

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 79.69  E-value: 7.01e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1886594609   905 FYRSRSRCGIINDPSnSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTYDFCP 981
Cdd:smart00832    1 KYYACSQCGILLSPR-GPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1300-1368 1.07e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


:

Pssm-ID: 462584  Cd Length: 68  Bit Score: 73.57  E-value: 1.07e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1886594609 1300 LCSLIpSQNAGFTKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGIAVTGWRNYTAC 1368
Cdd:pfam08742    1 KCGLL-SDSGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 597-650 2.88e-15

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 71.58  E-value: 2.88e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609  597 CPSFSHYSVCTSSCPDTCSDLTASQRCATPCTEGCECNEGFVLSTS-QCVPLHQC 650
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGgKCVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1372-1425 2.61e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 68.88  E-value: 2.61e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609 1372 CPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLD-GRSCILPHSC 1425
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 984-1036 4.34e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 68.50  E-value: 4.34e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609  984 CPENSHFEECMT-CTETCETLALGPICVDSCSEGCQCDEGYAL-QGSQCVPRSEC 1036
Cdd:cd19941      1 CPPNEVYSECGSaCPPTCANPNAPPPCTKQCVEGCFCPEGYVRnSGGKCVPPSQC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1684-1757 7.53e-11

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 60.05  E-value: 7.53e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609  1684 KMQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESCYLDGCYNQK-KLQLCGSLAAYGESCRSFGILSTEWIEKENC 1757
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGdCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2089-2121 4.38e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 4.38e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1886594609 2089 EDNGGCEQICTSRVEGPLCSCVTG-TLQEDGKSC 2121
Cdd:pfam14670    3 VNNGGCSHLCLNTPGGYTCSCPEGyELQDDGRTC 36
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 652-706 4.91e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam12714:

Pssm-ID: 450195  Cd Length: 54  Bit Score: 39.98  E-value: 4.91e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609  652 CDFHGHYYAMGEFfWATADCTVQCLCEeGGDVYCFNKTCRGDEVCTVEDGYRGCF 706
Cdd:pfam12714    2 KDAQGNYIPAGKT-WFSSGCTQSCTCT-GGNIQCQPFQCPPGTVCKDNDGSSNCH 54
 
Name Accession Description Interval E-value
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
98-254 6.43e-67

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 223.07  E-value: 6.43e-67
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609    98 PFWADVHNGIRGEIYYRETMDPAVLRRATKDIRKYFKDMATFSATWVFIVTWEEVTFYGGSSTTPVNTFQAVLVSDGSYT 177
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDGTNTFQAVLATDGSRT 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1886594609   178 FTLFNYYEINWTTGTASGGDPltglgGVMAQAGFNGGNLTNFFSLPGSRTPDIVNIQETTNVNVPGRWAFKVDGKEI 254
Cdd:smart00539   81 YAIFLYPSLGWTSDTTAGGDD-----GVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 1805-2059 2.98e-60

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 208.01  E-value: 2.98e-60
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1805 TCKASQMEVSISKCKLFQLGFEREGVRVNDRQCTG---IEGEDFISFQINNTKgnCGNIVQSNGTHIMYKNTVWIesANN 1881
Cdd:smart00241    1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPqftDATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLVV--SPF 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1882 TGNIITRDRTINVEFSCAYELDIKISLDSVVKPMLSVINltVPTQEGSFTTKMALYKNASYKHPYRQGEVVLttRDVLYV 1961
Cdd:smart00241   77 HPGFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTEL--SSVSEGPLTCSYRLYKDDSFGSPYQSADYVL--GDPVYH 152

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1962 GVFVVGADATHLILTLNKCYATPSRDSNDKLRYFIIEEGCQ--NIKDNTIGIEENgVSLTCRFHVTVFKFIgDYDEVHLH 2039
Cdd:smart00241  153 EWECDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPvdGYLDSTIPYNSN-PLHRARFSVKVFKFA-DRSLVYFH 230

                           250       260
                    ....*....|....*....|..
gi 1886594609  2040 CAVSLCDSEKYS--CKITCPQN 2059
Cdd:smart00241  231 CQIRLCDKDDGSscDGPACSSR 252
Zona_pellucida pfam00100
Zona pellucida-like domain;
1806-2057 5.74e-54

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 190.13  E-value: 5.74e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609 1806 CKASQMEVSISKCKLFQLGFEREGVR--VNDRQCTG---IEGEDFISFQINNTkgNCGNIVQSNGTHIMYKNTVWIESAN 1880
Cdd:pfam00100    1 CTPDTMTVSISKCLLVPSGLLSSLSLlgGLDPSCKPvsnTNGSPAVLFEFPLT--GCGTTVQVNGTHIIYSNTLYSSTDL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609 1881 NtGNIITRDRTINVEFSCAYELDIKISLDSVVKPmlsVINLTVPTQEGSFTTKMALYKNASYKHPYRQGEVVLTTRDVLY 1960
Cdd:pfam00100   79 R-SGIIRRTITRRLPFSCSYPRSSLVSLLVVAPP---SPVPITVSGSGVFLVSMDLYYDSSYTSPYSPYPVTVLLGDPLY 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609 1961 VGVFVVGADATHLILTLNKCYATPSRDSNDKLRYFIIEEGCQNIKDNTIG--IEENGVSLTCRFHVTVFKFIGDY-DEVH 2037
Cdd:pfam00100  155 VEVSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYPvsSLSNGPSHYVRFSFKAFRFVGSSiSQVY 234

                          250       260
                   ....*....|....*....|
gi 1886594609 2038 LHCAVSLCDSEKYSCKITCP 2057
Cdd:pfam00100  235 LHCSVSVCSSDSNSCGKSCS 254
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 313-477 3.73e-46

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 164.11  E-value: 3.73e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609   313 YCSPMET-STCVVFGEPHYHTFDGFLFHFQGSCAYLLARQClqtSSLPFFSVEAKNEHRGGSAvSWVKELSVEVNGYKIL 391
Cdd:smart00216    2 CCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC---SSEPTFSVLLKNVPCGGGA-TCLKSVKVELNGDEIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609   392 IPKGsYGKVKVNDLVTSLPVTLDLGAVKIYQSGMSTAVETDFGLL-VIFDGQHYASISVPGSYTNSTCGLCGNYNKNPLD 470
Cdd:smart00216   78 LKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 1886594609   471 DFLRPDG 477
Cdd:smart00216  157 DFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 322-478 4.16e-46

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 163.31  E-value: 4.16e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  322 CVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSlPFFSVEAKNEHRGGSAVsWVKELSVEVNGYKILIPKGsyGKVK 401
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD-FSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKG--GTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1886594609  402 VNDLVTSLPVTLDLGAVKIYQSGM-STAVETDFGLLVIFDGQHYASISVPGSYTNSTCGLCGNYNKNPLDDFLRPDGR 478
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFvVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 163-251 6.63e-39

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 140.51  E-value: 6.63e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  163 VNTFQAVLVSDGSYTFTLFNY--YEINWTTGTASGGdpLTGLGGVMAQAGFNGGN-LTNFFSLPGSRTPDIVNIQETTNV 239
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYpdGGIQWTTGKASGG--TNGLGGTPAQAGFSAGDgDGRYYELPGSGTDSIRNLTETSNV 78

                           90
                   ....*....|..
gi 1886594609  240 NVPGRWAFKVDG 251
Cdd:pfam06119   79 GVPGRWVFRIDS 90
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1100-1258 2.33e-37

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 138.27  E-value: 2.33e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609 1100 CIVSGYGHYLTFDGYPFDFQTSCPLILCTTgdrPSSDAFPKFIVTAKNEDRDpSLALWVKQVDVTMFGYSIVIHRAykHT 1179
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKD---CSEEPDFSFSVTNKNCNGG-ASGVCLKSVTVIVGDLEITLQKG--GT 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609 1180 VLVNNERLYLPLKLGQGKINIFSFGFHVV-VETDFGLKVVYDWKTFLSITVPRSMQNSTSGLCGRYNGHPDDDLEMPMGL 1258
Cdd:pfam00094   75 VLVNGQKVSLPYKSDGGEVEILGSGFVVVdLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1090-1257 6.87e-37

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 137.53  E-value: 6.87e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1090 YYC-QARTDASCIVSGYGHYLTFDGYPFDFQTSCPLILCTtgDRPSsdaFPKFIVTAKNEDRDPSLAlWVKQVDVTMFGY 1168
Cdd:smart00216    1 WCCtQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQ--DCSS---EPTFSVLLKNVPCGGGAT-CLKSVKVELNGD 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1169 SIVIHRAyKHTVLVNNERLYLPLKLGQGKINIFSFGFHVVVETDFGLKVV-YDWKTFLSITVPRSMQNSTSGLCGRYNGH 1247
Cdd:smart00216   75 EIELKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIQVtFDGLTLLSVQLPSKYRGKTCGLCGNFDGE 153

                           170
                    ....*....|
gi 1886594609  1248 PDDDLEMPMG 1257
Cdd:smart00216  154 PEDDFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1487-1639 9.15e-36

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 134.04  E-value: 9.15e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609 1487 CLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDISFQLIINFDKWSSPNlTIISPVYFYINEEQILINDRNTVKVNG 1566
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASG-VCLKSVTVIVGDLEITLQKGGTVLVNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1886594609 1567 TQVNVPFIT-GLATKIYSSeGFLVIDTSPDIQIHYNGYNV--IKISISERLQNKVCGLCGNFNGDLTDDYVTLRGK 1639
Cdd:pfam00094   80 QKVSLPYKSdGGEVEILGS-GFVVVDLSPGVGLQVDGDGRgqLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1477-1638 2.96e-34

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 129.83  E-value: 2.96e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1477 RGCVSTKT-SYCLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDISfqliINFDKWS-SPNLTIISPVYFYINEEQI 1554
Cdd:smart00216    1 WCCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTFS----VLLKNVPcGGGATCLKSVKVELNGDEI 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1555 LINDRN-TVKVNGTQVNVPFITGLAT-KIYSSEGFLVIDTSPDI-QIHYNGYNVIKISISERLQNKVCGLCGNFNGDLTD 1631
Cdd:smart00216   77 ELKDDNgKVTVNGQQVSLPYKTSDGSiQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 1886594609  1632 DYVTLRG 1638
Cdd:smart00216  157 DFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 713-866 2.94e-32

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 123.63  E-value: 2.94e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  713 CLLSQNQVLHTFDGAAYAFPSEFSYTLLRTCPEQPEYLEIDINKKKPDGGPAW-LRGLRILVANQEVKLGGVGaaEVKVN 791
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASGVcLKSVTVIVGDLEITLQKGG--TVLVN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1886594609  792 GQEVELPFFHLSGKLEIYRNKNSTTVESRGI-LSVQYSDTGLLYIRLSTVYFNCTGGLCGFFNANASDEFCLPNGK 866
Cdd:pfam00094   79 GQKVSLPYKSDGGEVEILGSGFVVVDLSPGVgLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 703-865 8.93e-32

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 122.90  E-value: 8.93e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609   703 RGCFPQRE-TVCLLSQNQVLHTFDGAAYAFPSEFSYTLLRTCPEQPEYlEIDINKKKPDGGPAWLRGLRILVANQEVKLG 781
Cdd:smart00216    1 WCCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTF-SVLLKNVPCGGGATCLKSVKVELNGDEIELK 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609   782 GVGAaEVKVNGQEVELPFFHLSGKLEIYRNKNSTTVE-SRGILSVQYSDTGLLYIRLSTVYFNCTGGLCGFFNANASDEF 860
Cdd:smart00216   80 DDNG-KVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVItSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDF 158


                    ....*
gi 1886594609   861 CLPNG 865
Cdd:smart00216  159 RTPDG 163
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 517-591 8.36e-24

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 96.64  E-value: 8.36e-24
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609   517 LYFGPDYCGFLNRTDGPLWECGTVVDPTAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRLQTGC 591
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 905-981 7.01e-18

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 79.69  E-value: 7.01e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1886594609   905 FYRSRSRCGIINDPSnSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTYDFCP 981
Cdd:smart00832    1 KYYACSQCGILLSPR-GPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 523-591 8.51e-18

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 79.35  E-value: 8.51e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1886594609  523 YCGFLNrTDGPLWECGTVVDPTAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRLQTGC 591
Cdd:pfam08742    1 KCGLLS-DSGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 911-980 8.65e-17

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 76.65  E-value: 8.65e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  911 RCGIINDpsNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTYDFC 980
Cdd:pfam08742    1 KCGLLSD--SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1300-1368 1.07e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 73.57  E-value: 1.07e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1886594609 1300 LCSLIpSQNAGFTKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGIAVTGWRNYTAC 1368
Cdd:pfam08742    1 KCGLL-SDSGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1298-1368 2.43e-15

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 72.76  E-value: 2.43e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1886594609  1298 QQLCSLIPSQNAGFTKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGIAVTGWRNYTAC 1368
Cdd:smart00832    5 CSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 597-650 2.88e-15

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 71.58  E-value: 2.88e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609  597 CPSFSHYSVCTSSCPDTCSDLTASQRCATPCTEGCECNEGFVLSTS-QCVPLHQC 650
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGgKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 597-650 3.33e-15

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 71.65  E-value: 3.33e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609  597 CPSFSHYSVCTSSCPDTCSDLTASQRCATPCTEGCECNEGFVLS-TSQCVPLHQC 650
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1372-1425 2.61e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 68.88  E-value: 2.61e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609 1372 CPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLD-GRSCILPHSC 1425
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1372-1425 3.46e-14

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 68.57  E-value: 3.46e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609 1372 CPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLD-GRSCILPHSC 1425
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 984-1036 4.34e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 68.50  E-value: 4.34e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609  984 CPENSHFEECMT-CTETCETLALGPICVDSCSEGCQCDEGYAL-QGSQCVPRSEC 1036
Cdd:cd19941      1 CPPNEVYSECGSaCPPTCANPNAPPPCTKQCVEGCFCPEGYVRnSGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 984-1036 2.24e-12

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 63.56  E-value: 2.24e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609  984 CPENSHFEECMT-CTETCETLALGPICVDSCSEGCQCDEGYALQ-GSQCVPRSEC 1036
Cdd:pfam01826    1 CPANEVYSECGSaCPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1684-1757 7.53e-11

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 60.05  E-value: 7.53e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609  1684 KMQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESCYLDGCYNQK-KLQLCGSLAAYGESCRSFGILSTEWIEKENC 1757
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGdCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1690-1757 2.95e-08

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 52.38  E-value: 2.95e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1886594609 1690 YCLKLTDmKGFFQPCYGLLDPLPFYESCYLDGC-YNQKKLQLCGSLAAYGESCRSFGILSTEWIEKENC 1757
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCsCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2089-2121 4.38e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 4.38e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1886594609 2089 EDNGGCEQICTSRVEGPLCSCVTG-TLQEDGKSC 2121
Cdd:pfam14670    3 VNNGGCSHLCLNTPGGYTCSCPEGyELQDDGRTC 36
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 652-706 4.91e-04

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 39.98  E-value: 4.91e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609  652 CDFHGHYYAMGEFfWATADCTVQCLCEeGGDVYCFNKTCRGDEVCTVEDGYRGCF 706
Cdd:pfam12714    2 KDAQGNYIPAGKT-WFSSGCTQSCTCT-GGNIQCQPFQCPPGTVCKDNDGSSNCH 54
 
Name Accession Description Interval E-value
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
98-254 6.43e-67

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 223.07  E-value: 6.43e-67
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609    98 PFWADVHNGIRGEIYYRETMDPAVLRRATKDIRKYFKDMATFSATWVFIVTWEEVTFYGGSSTTPVNTFQAVLVSDGSYT 177
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSQSSDGTNTFQAVLATDGSRT 80

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1886594609   178 FTLFNYYEINWTTGTASGGDPltglgGVMAQAGFNGGNLTNFFSLPGSRTPDIVNIQETTNVNVPGRWAFKVDGKEI 254
Cdd:smart00539   81 YAIFLYPSLGWTSDTTAGGDD-----GVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 1805-2059 2.98e-60

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 208.01  E-value: 2.98e-60
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1805 TCKASQMEVSISKCKLFQLGFEREGVRVNDRQCTG---IEGEDFISFQINNTKgnCGNIVQSNGTHIMYKNTVWIesANN 1881
Cdd:smart00241    1 QCGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPqftDATSAFVSFEVPLNG--CGTRRQVNPDGIVYSNTLVV--SPF 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1882 TGNIITRDRTINVEFSCAYELDIKISLDSVVKPMLSVINltVPTQEGSFTTKMALYKNASYKHPYRQGEVVLttRDVLYV 1961
Cdd:smart00241   77 HPGFITRDDRAAYHFQCFYPENEKVSLNLDVSTIPPTEL--SSVSEGPLTCSYRLYKDDSFGSPYQSADYVL--GDPVYH 152

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1962 GVFVVGADATHLILTLNKCYATPSRDSNDKLRYFIIEEGCQ--NIKDNTIGIEENgVSLTCRFHVTVFKFIgDYDEVHLH 2039
Cdd:smart00241  153 EWECDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPvdGYLDSTIPYNSN-PLHRARFSVKVFKFA-DRSLVYFH 230

                           250       260
                    ....*....|....*....|..
gi 1886594609  2040 CAVSLCDSEKYS--CKITCPQN 2059
Cdd:smart00241  231 CQIRLCDKDDGSscDGPACSSR 252
Zona_pellucida pfam00100
Zona pellucida-like domain;
1806-2057 5.74e-54

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 190.13  E-value: 5.74e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609 1806 CKASQMEVSISKCKLFQLGFEREGVR--VNDRQCTG---IEGEDFISFQINNTkgNCGNIVQSNGTHIMYKNTVWIESAN 1880
Cdd:pfam00100    1 CTPDTMTVSISKCLLVPSGLLSSLSLlgGLDPSCKPvsnTNGSPAVLFEFPLT--GCGTTVQVNGTHIIYSNTLYSSTDL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609 1881 NtGNIITRDRTINVEFSCAYELDIKISLDSVVKPmlsVINLTVPTQEGSFTTKMALYKNASYKHPYRQGEVVLTTRDVLY 1960
Cdd:pfam00100   79 R-SGIIRRTITRRLPFSCSYPRSSLVSLLVVAPP---SPVPITVSGSGVFLVSMDLYYDSSYTSPYSPYPVTVLLGDPLY 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609 1961 VGVFVVGADATHLILTLNKCYATPSRDSNDKLRYFIIEEGCQNIKDNTIG--IEENGVSLTCRFHVTVFKFIGDY-DEVH 2037
Cdd:pfam00100  155 VEVSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYPvsSLSNGPSHYVRFSFKAFRFVGSSiSQVY 234

                          250       260
                   ....*....|....*....|
gi 1886594609 2038 LHCAVSLCDSEKYSCKITCP 2057
Cdd:pfam00100  235 LHCSVSVCSSDSNSCGKSCS 254
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 313-477 3.73e-46

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 164.11  E-value: 3.73e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609   313 YCSPMET-STCVVFGEPHYHTFDGFLFHFQGSCAYLLARQClqtSSLPFFSVEAKNEHRGGSAvSWVKELSVEVNGYKIL 391
Cdd:smart00216    2 CCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDC---SSEPTFSVLLKNVPCGGGA-TCLKSVKVELNGDEIE 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609   392 IPKGsYGKVKVNDLVTSLPVTLDLGAVKIYQSGMSTAVETDFGLL-VIFDGQHYASISVPGSYTNSTCGLCGNYNKNPLD 470
Cdd:smart00216   78 LKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIqVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 1886594609   471 DFLRPDG 477
Cdd:smart00216  157 DFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 322-478 4.16e-46

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 163.31  E-value: 4.16e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  322 CVVFGEPHYHTFDGFLFHFQGSCAYLLARQCLQTSSlPFFSVEAKNEHRGGSAVsWVKELSVEVNGYKILIPKGsyGKVK 401
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPD-FSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKG--GTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1886594609  402 VNDLVTSLPVTLDLGAVKIYQSGM-STAVETDFGLLVIFDGQHYASISVPGSYTNSTCGLCGNYNKNPLDDFLRPDGR 478
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFvVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 163-251 6.63e-39

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 140.51  E-value: 6.63e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  163 VNTFQAVLVSDGSYTFTLFNY--YEINWTTGTASGGdpLTGLGGVMAQAGFNGGN-LTNFFSLPGSRTPDIVNIQETTNV 239
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYpdGGIQWTTGKASGG--TNGLGGTPAQAGFSAGDgDGRYYELPGSGTDSIRNLTETSNV 78

                           90
                   ....*....|..
gi 1886594609  240 NVPGRWAFKVDG 251
Cdd:pfam06119   79 GVPGRWVFRIDS 90
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1100-1258 2.33e-37

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 138.27  E-value: 2.33e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609 1100 CIVSGYGHYLTFDGYPFDFQTSCPLILCTTgdrPSSDAFPKFIVTAKNEDRDpSLALWVKQVDVTMFGYSIVIHRAykHT 1179
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKD---CSEEPDFSFSVTNKNCNGG-ASGVCLKSVTVIVGDLEITLQKG--GT 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609 1180 VLVNNERLYLPLKLGQGKINIFSFGFHVV-VETDFGLKVVYDWKTFLSITVPRSMQNSTSGLCGRYNGHPDDDLEMPMGL 1258
Cdd:pfam00094   75 VLVNGQKVSLPYKSDGGEVEILGSGFVVVdLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1090-1257 6.87e-37

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 137.53  E-value: 6.87e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1090 YYC-QARTDASCIVSGYGHYLTFDGYPFDFQTSCPLILCTtgDRPSsdaFPKFIVTAKNEDRDPSLAlWVKQVDVTMFGY 1168
Cdd:smart00216    1 WCCtQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQ--DCSS---EPTFSVLLKNVPCGGGAT-CLKSVKVELNGD 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1169 SIVIHRAyKHTVLVNNERLYLPLKLGQGKINIFSFGFHVVVETDFGLKVV-YDWKTFLSITVPRSMQNSTSGLCGRYNGH 1247
Cdd:smart00216   75 EIELKDD-NGKVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIQVtFDGLTLLSVQLPSKYRGKTCGLCGNFDGE 153

                           170
                    ....*....|
gi 1886594609  1248 PDDDLEMPMG 1257
Cdd:smart00216  154 PEDDFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 1487-1639 9.15e-36

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 134.04  E-value: 9.15e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609 1487 CLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDISFQLIINFDKWSSPNlTIISPVYFYINEEQILINDRNTVKVNG 1566
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASG-VCLKSVTVIVGDLEITLQKGGTVLVNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1886594609 1567 TQVNVPFIT-GLATKIYSSeGFLVIDTSPDIQIHYNGYNV--IKISISERLQNKVCGLCGNFNGDLTDDYVTLRGK 1639
Cdd:pfam00094   80 QKVSLPYKSdGGEVEILGS-GFVVVDLSPGVGLQVDGDGRgqLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 1477-1638 2.96e-34

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 129.83  E-value: 2.96e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1477 RGCVSTKT-SYCLAAGGGVFRTFDGAFLRFPANCAFVLSTICQKLPDISfqliINFDKWS-SPNLTIISPVYFYINEEQI 1554
Cdd:smart00216    1 WCCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTFS----VLLKNVPcGGGATCLKSVKVELNGDEI 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  1555 LINDRN-TVKVNGTQVNVPFITGLAT-KIYSSEGFLVIDTSPDI-QIHYNGYNVIKISISERLQNKVCGLCGNFNGDLTD 1631
Cdd:smart00216   77 ELKDDNgKVTVNGQQVSLPYKTSDGSiQIRSSGGYLVVITSLGLiQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPED 156


                    ....*..
gi 1886594609  1632 DYVTLRG 1638
Cdd:smart00216  157 DFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 713-866 2.94e-32

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 123.63  E-value: 2.94e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  713 CLLSQNQVLHTFDGAAYAFPSEFSYTLLRTCPEQPEYLEIDINKKKPDGGPAW-LRGLRILVANQEVKLGGVGaaEVKVN 791
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPDFSFSVTNKNCNGGASGVcLKSVTVIVGDLEITLQKGG--TVLVN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1886594609  792 GQEVELPFFHLSGKLEIYRNKNSTTVESRGI-LSVQYSDTGLLYIRLSTVYFNCTGGLCGFFNANASDEFCLPNGK 866
Cdd:pfam00094   79 GQKVSLPYKSDGGEVEILGSGFVVVDLSPGVgLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 703-865 8.93e-32

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 122.90  E-value: 8.93e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609   703 RGCFPQRE-TVCLLSQNQVLHTFDGAAYAFPSEFSYTLLRTCPEQPEYlEIDINKKKPDGGPAWLRGLRILVANQEVKLG 781
Cdd:smart00216    1 WCCTQEECsPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSEPTF-SVLLKNVPCGGGATCLKSVKVELNGDEIELK 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609   782 GVGAaEVKVNGQEVELPFFHLSGKLEIYRNKNSTTVE-SRGILSVQYSDTGLLYIRLSTVYFNCTGGLCGFFNANASDEF 860
Cdd:smart00216   80 DDNG-KVTVNGQQVSLPYKTSDGSIQIRSSGGYLVVItSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDF 158


                    ....*
gi 1886594609   861 CLPNG 865
Cdd:smart00216  159 RTPDG 163
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 517-591 8.36e-24

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 96.64  E-value: 8.36e-24
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609   517 LYFGPDYCGFLNRTDGPLWECGTVVDPTAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRLQTGC 591
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 905-981 7.01e-18

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 79.69  E-value: 7.01e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1886594609   905 FYRSRSRCGIINDPSnSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTYDFCP 981
Cdd:smart00832    1 KYYACSQCGILLSPR-GPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 523-591 8.51e-18

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 79.35  E-value: 8.51e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1886594609  523 YCGFLNrTDGPLWECGTVVDPTAFVHSCVYDLCSVRDNGTLLCQAIQAYALVCQALGIPIGDWRLQTGC 591
Cdd:pfam08742    1 KCGLLS-DSGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 911-980 8.65e-17

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 76.65  E-value: 8.65e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1886594609  911 RCGIINDpsNSSFLECHGVVNVTAYYRTCLFRLCQSGGNESELCDSVARYASACKNADVEVGPWRTYDFC 980
Cdd:pfam08742    1 KCGLLSD--SGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1300-1368 1.07e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 73.57  E-value: 1.07e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1886594609 1300 LCSLIpSQNAGFTKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGIAVTGWRNYTAC 1368
Cdd:pfam08742    1 KCGLL-SDSGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1298-1368 2.43e-15

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 72.76  E-value: 2.43e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1886594609  1298 QQLCSLIPSQNAGFTKCHSKVNPTFFYKNCLFDSCIDGGAVQTACSWLQNYASTCQTQGIAVTGWRNYTAC 1368
Cdd:smart00832    5 CSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 597-650 2.88e-15

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 71.58  E-value: 2.88e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609  597 CPSFSHYSVCTSSCPDTCSDLTASQRCATPCTEGCECNEGFVLSTS-QCVPLHQC 650
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGgKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 597-650 3.33e-15

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 71.65  E-value: 3.33e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609  597 CPSFSHYSVCTSSCPDTCSDLTASQRCATPCTEGCECNEGFVLS-TSQCVPLHQC 650
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 1372-1425 2.61e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 68.88  E-value: 2.61e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609 1372 CPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLD-GRSCILPHSC 1425
Cdd:cd19941      1 CPPNEVYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 1372-1425 3.46e-14

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 68.57  E-value: 3.46e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609 1372 CPPNSHYESCVSVCQPRCAAIRLKSDCNHYCVEGCQCDAGYVLD-GRSCILPHSC 1425
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 984-1036 4.34e-14

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 68.50  E-value: 4.34e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609  984 CPENSHFEECMT-CTETCETLALGPICVDSCSEGCQCDEGYAL-QGSQCVPRSEC 1036
Cdd:cd19941      1 CPPNEVYSECGSaCPPTCANPNAPPPCTKQCVEGCFCPEGYVRnSGGKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 984-1036 2.24e-12

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 63.56  E-value: 2.24e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609  984 CPENSHFEECMT-CTETCETLALGPICVDSCSEGCQCDEGYALQ-GSQCVPRSEC 1036
Cdd:pfam01826    1 CPANEVYSECGSaCPPTCANLSPPDVCPEPCVEGCVCPPGFVRNsGGKCVPPSDC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1684-1757 7.53e-11

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 60.05  E-value: 7.53e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609  1684 KMQGDGYCLKLTDMKGFFQPCYGLLDPLPFYESCYLDGCYNQK-KLQLCGSLAAYGESCRSFGILSTEWIEKENC 1757
Cdd:smart00832    1 KYYACSQCGILLSPRGPFAACHSVVDPEPFFENCVYDTCACGGdCECLCDALAAYAAACAEAGVCISPWRTPTFC 75
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1690-1757 2.95e-08

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 52.38  E-value: 2.95e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1886594609 1690 YCLKLTDmKGFFQPCYGLLDPLPFYESCYLDGC-YNQKKLQLCGSLAAYGESCRSFGILSTEWIEKENC 1757
Cdd:pfam08742    1 KCGLLSD-SGPFAPCHSVVDPEPYFEACVYDMCsCGGDDECLCAALAAYARACQAAGVCIGDWRTPTFC 68
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2089-2121 4.38e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 4.38e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1886594609 2089 EDNGGCEQICTSRVEGPLCSCVTG-TLQEDGKSC 2121
Cdd:pfam14670    3 VNNGGCSHLCLNTPGGYTCSCPEGyELQDDGRTC 36
TILa pfam12714
TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is ...
 652-706 4.91e-04

TILa domain; This cysteine rich domain occurs along side the TIL pfam01826 domain and is likely to be a distantly related relative.


Pssm-ID: 432736  Cd Length: 54  Bit Score: 39.98  E-value: 4.91e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1886594609  652 CDFHGHYYAMGEFfWATADCTVQCLCEeGGDVYCFNKTCRGDEVCTVEDGYRGCF 706
Cdd:pfam12714    2 KDAQGNYIPAGKT-WFSSGCTQSCTCT-GGNIQCQPFQCPPGTVCKDNDGSSNCH 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH