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Conserved domains on  [gi|1735196862|gb|KAA0038664|]
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uncharacterized protein E6C27_scaffold92G002020 [Cucumis melo var. makuwa]

Protein Classification

telomere repeat binding factor family protein( domain architecture ID 10184738)

telomere repeat binding factor (TRF) family protein binds directly to the telomeric double-stranded TTAGGG repeat through its SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain, and negatively regulates telomere length

CATH:  1.20.58.1880
Gene Ontology:  GO:0003677|GO:0006355|GO:0003700
PubMed:  8882580|12757977|15040448|16877755
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 209-257 3.95e-14

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


:

Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 66.44  E-value: 3.95e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1735196862 209 KPWSKAEDLELIAAVEKCGEGNWANILKG-DFKGDRTASQLSQRWSVIRK 257
Cdd:cd11660     1 RKWTDEEDEALVEGVEKYGVGNWAKILKDyFFVNNRTSVDLKDKWRNLKK 50
 
Name Accession Description Interval E-value
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 209-257 3.95e-14

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 66.44  E-value: 3.95e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1735196862 209 KPWSKAEDLELIAAVEKCGEGNWANILKG-DFKGDRTASQLSQRWSVIRK 257
Cdd:cd11660     1 RKWTDEEDEALVEGVEKYGVGNWAKILKDyFFVNNRTSVDLKDKWRNLKK 50
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
208-252 1.47e-09

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 53.38  E-value: 1.47e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1735196862  208 RKPWSKAEDLELIAAVEKCGEGNWANILKgdFKGDRTASQLSQRW 252
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAK--ELPGRTAEQCRERW 43
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 208-252 5.32e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 43.26  E-value: 5.32e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1735196862 208 RKPWSKAEDLELIAAVEKCGeGNWANILKgdFKGDRTASQLSQRW 252
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAK--LLPGRTDNQCKNRW 42
 
Name Accession Description Interval E-value
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 209-257 3.95e-14

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 66.44  E-value: 3.95e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1735196862 209 KPWSKAEDLELIAAVEKCGEGNWANILKG-DFKGDRTASQLSQRWSVIRK 257
Cdd:cd11660     1 RKWTDEEDEALVEGVEKYGVGNWAKILKDyFFVNNRTSVDLKDKWRNLKK 50
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
208-252 1.47e-09

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 53.38  E-value: 1.47e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1735196862  208 RKPWSKAEDLELIAAVEKCGEGNWANILKgdFKGDRTASQLSQRW 252
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAK--ELPGRTAEQCRERW 43
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 210-252 5.23e-09

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 51.81  E-value: 5.23e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1735196862 210 PWSKAEDLELIAAVEKCGEGNWANILKgdFKGDRTASQLSQRW 252
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAK--ELPGRTPKQCRERW 41
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 208-252 5.32e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 43.26  E-value: 5.32e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1735196862 208 RKPWSKAEDLELIAAVEKCGeGNWANILKgdFKGDRTASQLSQRW 252
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAK--LLPGRTDNQCKNRW 42
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 211-252 4.06e-05

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 41.53  E-value: 4.06e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1735196862 211 WSKAEDLELIAAVEKCGeGNWANIlkGDFKGDRTASQLSQRW 252
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQI--AKELGRRTPKQCFDRW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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