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Conserved domains on  [gi|1733551943|dbj|GER01363|]
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hypothetical protein JCM17845_19860 [Iodidimonas gelatinilytica]

Protein Classification

PleD family two-component system response regulator( domain architecture ID 11467115)

PleD family two-component system response regulator similar to Pseudomonas syringae diguanylate cyclase response regulator WspR, a potent molecular switch that controls biofilm formation, and to Borreliella burgdorferi response regulatory protein 1 (Rrp1), an important regulator of core cellular functions

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
1-93 4.74e-14

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 67.24  E-value: 4.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLE-SGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLafWLICGFRG-- 77
Cdd:COG3706    48 LILLDLEMPDMDGLELCRRLRAdPRTADIPIIFLTALDDEEDRARALEAGADDYLTKPFDPEELLARV--DLVARYGGee 125
                          90       100
                  ....*....|....*....|
gi 1733551943  78 ----LPRTARLNAISALESM 93
Cdd:COG3706   126 failLPGTDLEGALAVAERI 145
 
Name Accession Description Interval E-value
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
1-93 4.74e-14

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 67.24  E-value: 4.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLE-SGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLafWLICGFRG-- 77
Cdd:COG3706    48 LILLDLEMPDMDGLELCRRLRAdPRTADIPIIFLTALDDEEDRARALEAGADDYLTKPFDPEELLARV--DLVARYGGee 125
                          90       100
                  ....*....|....*....|
gi 1733551943  78 ----LPRTARLNAISALESM 93
Cdd:COG3706   126 failLPGTDLEGALAVAERI 145
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
1-72 8.32e-14

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 65.04  E-value: 8.32e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRL-LESGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLAFWLI 72
Cdd:cd17598    45 LVISDIVMPEMDGYELCRKIkSDPDLKDIPVILLTTLSDPRDVIRGLECGADNFITKPYDEKYLLSRIKYILV 117
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
1-68 5.83e-12

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 59.86  E-value: 5.83e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGLRPcPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLA 68
Cdd:pfam00072  45 LILLDINMPGMDGLELLKRIRRRDPTT-PVIILTAHGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
1-67 1.38e-07

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 50.31  E-value: 1.38e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVtRLLESGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:PRK09836   47 LIILDIMLPDVNGWDIV-RMLRSANKGMPILLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARV 112
 
Name Accession Description Interval E-value
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
1-93 4.74e-14

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 67.24  E-value: 4.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLE-SGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLafWLICGFRG-- 77
Cdd:COG3706    48 LILLDLEMPDMDGLELCRRLRAdPRTADIPIIFLTALDDEEDRARALEAGADDYLTKPFDPEELLARV--DLVARYGGee 125
                          90       100
                  ....*....|....*....|
gi 1733551943  78 ----LPRTARLNAISALESM 93
Cdd:COG3706   126 failLPGTDLEGALAVAERI 145
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
1-72 8.32e-14

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 65.04  E-value: 8.32e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRL-LESGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLAFWLI 72
Cdd:cd17598    45 LVISDIVMPEMDGYELCRKIkSDPDLKDIPVILLTTLSDPRDVIRGLECGADNFITKPYDEKYLLSRIKYILV 117
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
1-67 8.20e-13

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 64.59  E-value: 8.20e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGlRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:COG0745    48 LILLDLMLPGMDGLEVCRRLRARP-SDIPIIMLTARDDEEDRVRGLEAGADDYLTKPFDPEELLARI 113
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
1-71 1.39e-12

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 62.18  E-value: 1.39e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLE-SGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLAFWL 71
Cdd:COG0784    52 LILLDINMPGMDGLELLRRIRAlPRLPDIPIIALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLL 123
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
1-68 5.83e-12

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 59.86  E-value: 5.83e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGLRPcPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLA 68
Cdd:pfam00072  45 LILLDINMPGMDGLELLKRIRRRDPTT-PVIILTAHGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
1-56 6.34e-12

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 59.73  E-value: 6.34e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   1 MIVSDVEMPDMSGHAmVTRLLESGLRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17574    44 LIILDVMLPGMDGFE-VCRRLREKGSDIPIIMLTAKDEEEDKVLGLELGADDYITK 98
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
1-68 1.26e-11

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 61.72  E-value: 1.26e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRL-LESGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLA 68
Cdd:COG3437    53 LILLDVRMPGMDGFELLRLLrADPSTRDIPVIFLTALADPEDRERALEAGADDYLTKPFDPEELLARVR 121
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
1-56 1.33e-10

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 56.08  E-value: 1.33e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGlRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd00156    44 LVLLDLMMPGMDGLELLRKLRELP-PDIPVIVLTAKADEEDAVRALELGADDYLVK 98
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
1-67 8.38e-10

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 54.31  E-value: 8.38e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGlRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:cd17627    45 AVVLDVMMPRLDGLEVCRRLRAAG-NDLPILVLTARDSVSDRVAGLDAGADDYLVKPFALEELLARV 110
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
2-56 8.41e-10

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 53.98  E-value: 8.41e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1733551943   2 IVSDVEMPDMSGHAMVTRLLESGlRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd19935    46 IILDVMLPGLDGLEVLRRLRAAG-KQTPVLMLTARDSVEDRVKGLDLGADDYLVK 99
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
1-56 2.55e-09

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 52.89  E-value: 2.55e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   1 MIVSDVEMPDMSGHaMVTRLLES--GLRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17538    46 LILLDVMMPGMDGF-EVCRRLKEdpETRHIPVIMITALDDREDRIRGLEAGADDFLSK 102
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
2-67 9.63e-09

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 51.45  E-value: 9.63e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   2 IVSDVEMPDMSGHAMVTRLLESGLRpCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:cd17625    45 IILDIMLPGMDGLEVLKSLREEGIE-TPVLLLTALDAVEDRVKGLDLGADDYLPKPFSLAELLARI 109
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
2-67 1.03e-08

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 51.58  E-value: 1.03e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   2 IVSDVEMPDMSGHAMVTRLLESGLRpCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:cd17615    47 VVLDIMLPDMDGLEVLRRLRADGPD-VPVLFLTAKDSVEDRIAGLTAGGDDYVTKPFSLEEVVARL 111
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
1-56 2.42e-08

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 50.20  E-value: 2.42e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   1 MIVSDVEMPDMSGHAmVTRLLESGLRPC--PILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd19920    45 LILLDVMMPGMDGFE-VCRRLKADPATRhiPVIFLTALTDTEDKVKGFELGAVDYITK 101
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
1-57 4.75e-08

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 49.68  E-value: 4.75e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLES-GLRPCPILFLSANDTAQDMLRGLECGGDDFLLKG 57
Cdd:cd19924    54 LIITDIEMPKMDGYELTFELRDDpRLANIPVILNSSLSGEFSRARGKKVGADAYLAKF 111
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
5-56 6.08e-08

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 49.39  E-value: 6.08e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1733551943   5 DVEMPDMSGHAMVTRL--LESGLRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17546    49 DLQMPVMDGLEATRRIreLEGGGRRTPIIALTANALEEDREKCLEAGMDDYLSK 102
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
1-67 9.20e-08

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 48.64  E-value: 9.20e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGlRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:cd17624    45 LVILDLGLPDGDGLDLLRRWRRQG-QSLPVLILTARDGVDDRVAGLDAGADDYLVKPFALEELLARL 110
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
2-67 1.26e-07

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 48.28  E-value: 1.26e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   2 IVSDVEMPDMSGHAmVTRLLESGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:cd17535    48 VLMDLSMPGMDGIE-ALRRLRRRYPDLKVIVLTAHDDPEYVLRALKAGAAGYLLKDSSPEELIEAI 112
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
1-67 1.38e-07

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 50.31  E-value: 1.38e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVtRLLESGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:PRK09836   47 LIILDIMLPDVNGWDIV-RMLRSANKGMPILLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARV 112
PRK15479 PRK15479
transcriptional regulator TctD;
1-67 1.40e-07

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 50.11  E-value: 1.40e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGlRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:PRK15479   47 LAVLDINMPGMDGLEVLQRLRKRG-QTLPVLLLTARSAVADRVKGLNVGADDYLPKPFELEELDARL 112
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
2-56 1.54e-07

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 47.85  E-value: 1.54e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1733551943   2 IVSDVEMPDMSGHAMVTRLLESGLRpCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:COG4753    49 VITDINMPGMDGLELLEAIRELDPD-TKIIILSGYSDFEYAQEAIKLGADDYLLK 102
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
1-68 3.44e-07

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 49.58  E-value: 3.44e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGLRpCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLA 68
Cdd:COG2204    49 LVLLDLRMPGMDGLELLRELRALDPD-LPVILLTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVE 115
REC_typeA_ARR cd17581
phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and ...
1-56 4.36e-07

phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and similar proteins; Type-A response regulators of Arabidopsis (ARRs) are involved in cytokinin signaling, which involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Type-A ARRs function downstream of and are regulated by type-B ARRs, which are a class of MYB-type transcription factors. As primary cytokinin response genes, type-A ARRs act as redundant negative feedback regulators of cytokinin signaling by inactivating the phosphorelay. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-A ARRs are similar in domain structure to CheY, in that they lack a typical output domain and only contain a stand-alone receiver (REC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381119 [Multi-domain]  Cd Length: 122  Bit Score: 46.98  E-value: 4.36e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESG-LRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17581    56 MIITDYCMPGMTGYDLLKKVKESSaLKEIPVVIMSSENIPTRISRCLEEGAEDFLLK 112
PRK10643 PRK10643
two-component system response regulator PmrA;
1-66 1.53e-06

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 46.95  E-value: 1.53e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGLRpCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDR 66
Cdd:PRK10643   47 LVVLDLGLPDEDGLHLLRRWRQKKYT-LPVLILTARDTLEDRVAGLDVGADDYLVKPFALEELHAR 111
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
1-56 8.05e-06

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 43.39  E-value: 8.05e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRL-LESGLRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17618    47 LILLDWMLPGGSGIQFIRRLkRDEMTRDIPIIMLTARGEEEDKVRGLEAGADDYITK 103
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
2-67 9.33e-06

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 43.43  E-value: 9.33e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   2 IVSDVEMPDMSGHAMVTRLLESGlRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:cd19934    46 VVLDLGLPGMDGLSVLRRWRSEG-RATPVLILTARDSWQDKVEGLDAGADDYLTKPFHIEELLARL 110
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
1-56 1.13e-05

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 43.20  E-value: 1.13e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLES-GLRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17551    48 LILLDYMMPGMDGLEFIRRLRALpGLEDVPIVMITADTDREVRLRALEAGATDFLTK 104
PLN03029 PLN03029
type-a response regulator protein; Provisional
1-67 1.63e-05

type-a response regulator protein; Provisional


Pssm-ID: 215544 [Multi-domain]  Cd Length: 222  Bit Score: 44.25  E-value: 1.63e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESG-LRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLmDRL 67
Cdd:PLN03029   75 LIITDYCMPGMTGYDLLKKIKESSsLRNIPVVIMSSENVPSRITRCLEEGAEEFFLKPVQLSDL-NRL 141
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
1-56 1.79e-05

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 42.05  E-value: 1.79e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGlrPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd19936    45 LAILDIKMPRMDGMELLQRLRQKS--TLPVIFLTSKDDEIDEVFGLRMGADDYITK 98
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
2-67 1.95e-05

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 42.20  E-value: 1.95e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   2 IVSDVEMPDMSGHAMVTRLLESGLRPcPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:cd17537    48 LVLDVRMPGMSGLELQDELLARGSNI-PIIFITGHGDVPMAVEAMKAGAVDFLEKPFRDQVLLDAI 112
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
27-67 2.06e-05

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 42.27  E-value: 2.06e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1733551943  27 PCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:cd18159    69 NVPIIFISSRDDNMDQVMAINMGGDDYITKPFDLDVLLAKI 109
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
2-56 2.29e-05

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 42.65  E-value: 2.29e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1733551943   2 IVSDVEMPDMSGHAMVTRLLESGlRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:COG4565    53 ILLDIYLPDGDGLELLRELRARG-PDVDVIVITAARDPETVREALRAGVVDYLIK 106
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
1-56 5.19e-05

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 41.14  E-value: 5.19e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGlrPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17623    45 LVVLDVMLPKMNGLDVLKELRKTS--QVPVLMLTARGDDIDRILGLELGADDYLPK 98
PRK11517 PRK11517
DNA-binding response regulator HprR;
1-67 5.38e-05

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 42.58  E-value: 5.38e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHaMVTRLLESGlRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:PRK11517   47 LIILDIMLPGMDGW-QILQTLRTA-KQTPVICLTARDSVDDRVRGLDSGANDYLVKPFSFSELLARV 111
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
1-70 5.86e-05

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 43.42  E-value: 5.86e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGLRpCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLAFW 70
Cdd:PRK10841  848 IVLTDVNMPNMDGYRLTQRLRQLGLT-LPVIGVTANALAEEKQRCLEAGMDSCLSKPVTLDVLKQTLTVY 916
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
1-56 8.17e-05

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 40.47  E-value: 8.17e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGLrPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17616    45 IILLDLNLPDMSGYEVLRTLRLAKV-KTPILILSGLADIEDKVKGLGFGADDYMTK 99
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
1-56 8.65e-05

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 41.87  E-value: 8.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLE--SGLrpcPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:PRK11083   50 LVILDVGLPDISGFELCRQLLAfhPAL---PVIFLTARSDEVDRLVGLEIGADDYVAK 104
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
2-56 1.61e-04

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 39.46  E-value: 1.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   2 IVSDVEMPDMSGHAMVTRLLE-SGLrpcPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17620    46 IILDLGLPDMDGLEVIRRLREwSAV---PVIVLSARDEESDKIAALDAGADDYLTK 98
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
1-56 2.30e-04

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 39.42  E-value: 2.30e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLES-GLRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17544    48 LVITDYNMPEMDGFELVREIRKKySRDQLAIIGISASGDNALSARFIKAGANDFLTK 104
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
1-56 2.34e-04

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 38.90  E-value: 2.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRL-LESGLRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd19927    45 LIISDIIMPGVDGYSLLGKLrKNADFDTIPVIFLTAKGMTSDRIKGYNAGCDGYLSK 101
pleD PRK09581
response regulator PleD; Reviewed
2-56 3.27e-04

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 40.65  E-value: 3.27e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   2 IVSDVEMPDMSGHAmVTRLLESGLRP--CPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:PRK09581   50 ILLDVMMPGMDGFE-VCRRLKSDPATthIPVVMVTALDDPEDRVRGLEAGADDFLTK 105
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
1-56 3.93e-04

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 38.50  E-value: 3.93e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESG-LRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17602    45 LILIDIDMPDLDGYELCSLLRKSSaLKDTPIIMLTGKDGLVDRIRAKMAGASGYLTK 101
psREC_PRR cd17582
pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response ...
1-56 4.11e-04

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.


Pssm-ID: 381120 [Multi-domain]  Cd Length: 104  Bit Score: 38.54  E-value: 4.11e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESG-LRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17582    47 LILTEVDLPVSSGFKLLSYIMRHKiCKNIPVIMMSSQDSVGVVFKCLSKGAADYLVK 103
PRK10693 PRK10693
two-component system response regulator RssB;
1-56 4.35e-04

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 40.36  E-value: 4.35e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGLRpCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:PRK10693   20 LIICDLAMPRMNGIEFVEHLRNRGDQ-TPVLVISATENMADIAKALRLGVQDVLLK 74
orf27 CHL00148
Ycf27; Reviewed
1-56 5.26e-04

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 39.70  E-value: 5.26e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLL-ESGLrpcPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:CHL00148   53 LVILDVMMPKLDGYGVCQEIRkESDV---PIIMLTALGDVSDRITGLELGADDYVVK 106
PRK10336 PRK10336
two-component system response regulator QseB;
2-67 5.95e-04

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 39.49  E-value: 5.95e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   2 IVSDVEMPDMSGHAMVTRLLESGLRPcPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:PRK10336   48 VILDLTLPGMDGRDILREWREKGQRE-PVLILTARDALAERVEGLRLGADDYLCKPFALIEVAARL 112
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
5-56 7.43e-04

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 38.14  E-value: 7.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1733551943   5 DVEMPDMSGHAMVTRLLEsgLRPCPILFLSANDT--AQDMLRGLECGGDDFLLK 56
Cdd:cd17541    53 DIEMPVMDGLEALRRIMA--ERPTPVVMVSSLTEegAEITLEALELGAVDFIAK 104
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
5-56 9.48e-04

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 39.03  E-value: 9.48e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1733551943   5 DVEMPDMSGHAMVtRLLESGLRPCPILFLSANDtaQDMLRGLECGGDDFLLK 56
Cdd:COG3279    54 DIQMPGLDGFELA-RQLRELDPPPPIIFTTAYD--EYALEAFEVNAVDYLLK 102
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
1-56 1.03e-03

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 38.86  E-value: 1.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGL--RpcpILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:PRK10651   55 LILLDLNMPGMNGLETLDKLREKSLsgR---IVVFSVSNHEEDVVTALKRGADGYLLK 109
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
2-68 1.23e-03

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 38.54  E-value: 1.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733551943   2 IVSDVEMPDMSGHAMVTRLLESGLRPcPILFLSAN---DTAQDMLRGlecGGDDFLLKGGDLAHLMDRLA 68
Cdd:COG4566    47 LLLDVRMPGMSGLELQEELAARGSPL-PVIFLTGHgdvPMAVRAMKA---GAVDFLEKPFDDQALLDAVR 112
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
1-56 1.69e-03

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 36.87  E-value: 1.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRL-LESGLRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd19937    44 LIILDLMLPGIDGLEVCRILrSDPKTSSIPIIMLTAKGEEFDKVLGLELGADDYITK 100
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
1-67 2.85e-03

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 37.39  E-value: 2.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRL-LESGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:PRK10161   49 LILLDWMLPGGSGIQFIKHLkRESMTRDIPVVMLTARGEEEDRVRGLETGADDYITKPFSPKELVARI 116
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
29-67 3.23e-03

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 36.20  E-value: 3.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1733551943  29 PILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:cd17622    73 PILLLTALDSDIDHILGLELGADDYVVKPVEPAVLLARL 111
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
1-56 3.46e-03

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 35.91  E-value: 3.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRL-LESGLrpcPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17626    47 LVLLDLMLPGIDGIEVCRQIrAESGV---PIVMLTAKSDTVDVVLGLESGADDYVAK 100
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
1-65 3.71e-03

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 35.90  E-value: 3.71e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLE-SGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMD 65
Cdd:cd17580    45 VILSDIGMPGMDGYELARRLRElPWLANTPAIALTGYGQPEDRERALEAGFDAHLVKPVDPDELIE 110
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
2-56 4.33e-03

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 35.78  E-value: 4.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   2 IVSDVEMPDMSGHAMVTRLLESGLRpCPILFLSANDT---AQdmlRGLECGGDDFLLK 56
Cdd:cd17536    49 VITDIRMPGMDGLELIEKIRELYPD-IKIIILSGYDDfeyAQ---KAIRLGVVDYLLK 102
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
2-56 4.78e-03

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 35.68  E-value: 4.78e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   2 IVSDVEMPDMSGHAMVTRL-LESGLrpcPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17584    48 VITDVHMPDMDGFEFLELIrLEMDL---PVIMMSADGSTSTVMKGLAHGACDYLLK 100
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
3-65 6.92e-03

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 35.33  E-value: 6.92e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1733551943   3 VSDVEMPDMSGHAMVTRLLESGLRpCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMD 65
Cdd:cd19930    49 ILDIEMPGRTGLEVAAELREELPD-TKVLIVTTFGRPGYFRRALAAGVDGYVLKDRPIEELAD 110
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
2-56 7.11e-03

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 36.67  E-value: 7.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   2 IVSDVEMPDMSGHAMVTRLLEsgLRPCPILFLSA--NDTAQDMLRGLECGGDDFLLK 56
Cdd:PRK00742   53 ITLDVEMPVMDGLDALEKIMR--LRPTPVVMVSSltERGAEITLRALELGAVDFVTK 107
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
1-56 7.20e-03

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 34.87  E-value: 7.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLleSGLRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17621    45 IVLLDLMLPGLSGTEVCRQL--RARSNVPVIMVTAKDSEIDKVVGLELGADDYVTK 98
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
1-56 7.98e-03

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 35.02  E-value: 7.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGLRpCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd19931    47 LILLDLNMKGMSGLDTLKALREEGVS-ARIVILTVSDAEDDVVTALRAGADGYLLK 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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