Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLE-SGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLafWLICGFRG-- 77
Cdd:COG3706    48 LILLDLEMPDMDGLELCRRLRAdPRTADIPIIFLTALDDEEDRARALEAGADDYLTKPFDPEELLARV--DLVARYGGee 125

                          90       100
                  ....*....|....*....|
gi 1733551943  78 ----LPRTARLNAISALESM 93
Cdd:COG3706   126 failLPGTDLEGALAVAERI 145

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLE-SGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLafWLICGFRG-- 77
Cdd:COG3706    48 LILLDLEMPDMDGLELCRRLRAdPRTADIPIIFLTALDDEEDRARALEAGADDYLTKPFDPEELLARV--DLVARYGGee 125

                          90       100
                  ....*....|....*....|
gi 1733551943  78 ----LPRTARLNAISALESM 93
Cdd:COG3706   126 failLPGTDLEGALAVAERI 145

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGLRPcPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLA 68
Cdd:pfam00072  45 LILLDINMPGMDGLELLKRIRRRDPTT-PVIILTAHGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLE-SGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLafWLICGFRG-- 77
Cdd:COG3706    48 LILLDLEMPDMDGLELCRRLRAdPRTADIPIIFLTALDDEEDRARALEAGADDYLTKPFDPEELLARV--DLVARYGGee 125

                          90       100
                  ....*....|....*....|
gi 1733551943  78 ----LPRTARLNAISALESM 93
Cdd:COG3706   126 failLPGTDLEGALAVAERI 145

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGlRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:COG0745    48 LILLDLMLPGMDGLEVCRRLRARP-SDIPIIMLTARDDEEDRVRGLEAGADDYLTKPFDPEELLARI 113

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGLRPcPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLA 68
Cdd:pfam00072  45 LILLDINMPGMDGLELLKRIRRRDPTT-PVIILTAHGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRL-LESGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLA 68
Cdd:COG3437    53 LILLDVRMPGMDGFELLRLLrADPSTRDIPVIFLTALADPEDRERALEAGADDYLTKPFDPEELLARVR 121

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGlRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:cd17627    45 AVVLDVMMPRLDGLEVCRRLRAAG-NDLPILVLTARDSVSDRVAGLDAGADDYLVKPFALEELLARV 110

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   1 MIVSDVEMPDMSGHaMVTRLLES--GLRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17538    46 LILLDVMMPGMDGF-EVCRRLKEdpETRHIPVIMITALDDREDRIRGLEAGADDFLSK 102

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   2 IVSDVEMPDMSGHAMVTRLLESGLRpCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:cd17615    47 VVLDIMLPDMDGLEVLRRLRADGPD-VPVLFLTAKDSVEDRIAGLTAGGDDYVTKPFSLEEVVARL 111

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLES-GLRPCPILFLSANDTAQDMLRGLECGGDDFLLKG 57
Cdd:cd19924    54 LIITDIEMPKMDGYELTFELRDDpRLANIPVILNSSLSGEFSRARGKKVGADAYLAKF 111

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGlRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:cd17624    45 LVILDLGLPDGDGLDLLRRWRRQG-QSLPVLILTARDGVDDRVAGLDAGADDYLVKPFALEELLARL 110

DNA-binding transcriptional activator CusR; Provisional

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVtRLLESGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:PRK09836   47 LIILDIMLPDVNGWDIV-RMLRSANKGMPILLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARV 112

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1733551943   2 IVSDVEMPDMSGHAMVTRLLESGLRpCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:COG4753    49 VITDINMPGMDGLELLEAIRELDPD-TKIIILSGYSDFEYAQEAIKLGADDYLLK 102

phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and similar proteins; Type-A response regulators of Arabidopsis (ARRs) are involved in cytokinin signaling, which involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Type-A ARRs function downstream of and are regulated by type-B ARRs, which are a class of MYB-type transcription factors. As primary cytokinin response genes, type-A ARRs act as redundant negative feedback regulators of cytokinin signaling by inactivating the phosphorelay. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-A ARRs are similar in domain structure to CheY, in that they lack a typical output domain and only contain a stand-alone receiver (REC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESG-LRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17581    56 MIITDYCMPGMTGYDLLKKVKESSaLKEIPVVIMSSENIPTRISRCLEEGAEDFLLK 112

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRL-LESGLRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17618    47 LILLDWMLPGGSGIQFIRRLkRDEMTRDIPIIMLTARGEEEDKVRGLEAGADDYITK 103

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLES-GLRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17551    48 LILLDYMMPGMDGLEFIRRLRALpGLEDVPIVMITADTDREVRLRALEAGATDFLTK 104

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGlrPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd19936    45 LAILDIKMPRMDGMELLQRLRQKS--TLPVIFLTSKDDEIDEVFGLRMGADDYITK 98

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1733551943  27 PCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:cd18159    69 NVPIIFISSRDDNMDQVMAINMGGDDYITKPFDLDVLLAKI 109

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGlrPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17623    45 LVVLDVMLPKMNGLDVLKELRKTS--QVPVLMLTARGDDIDRILGLELGADDYLPK 98

two-component system sensor histidine kinase RcsC;

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGLRpCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRLAFW 70
Cdd:PRK10841  848 IVLTDVNMPNMDGYRLTQRLRQLGLT-LPVIGVTANALAEEKQRCLEAGMDSCLSKPVTLDVLKQTLTVY 916

DNA-binding response regulator CreB; Provisional

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLE--SGLrpcPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:PRK11083   50 LVILDVGLPDISGFELCRQLLAfhPAL---PVIFLTARSDEVDRLVGLEIGADDYVAK 104

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLES-GLRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17544    48 LVITDYNMPEMDGFELVREIRKKySRDQLAIIGISASGDNALSARFIKAGANDFLTK 104

response regulator PleD; Reviewed

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   2 IVSDVEMPDMSGHAmVTRLLESGLRP--CPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:PRK09581   50 ILLDVMMPGMDGFE-VCRRLKSDPATthIPVVMVTALDDPEDRVRGLEAGADDFLTK 105

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESG-LRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17582    47 LILTEVDLPVSSGFKLLSYIMRHKiCKNIPVIMMSSQDSVGVVFKCLSKGAADYLVK 103

Ycf27; Reviewed

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLL-ESGLrpcPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:CHL00148   53 LVILDVMMPKLDGYGVCQEIRkESDV---PIIMLTALGDVSDRITGLELGADDYVVK 106

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1733551943   5 DVEMPDMSGHAMVTRLLEsgLRPCPILFLSANDT--AQDMLRGLECGGDDFLLK 56
Cdd:cd17541    53 DIEMPVMDGLEALRRIMA--ERPTPVVMVSSLTEegAEITLEALELGAVDFIAK 104

transcriptional regulator NarL; Provisional

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGL--RpcpILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:PRK10651   55 LILLDLNMPGMNGLETLDKLREKSLsgR---IVVFSVSNHEEDVVTALKRGADGYLLK 109

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRL-LESGLRPCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd19937    44 LIILDLMLPGIDGLEVCRILrSDPKTSSIPIIMLTAKGEEFDKVLGLELGADDYITK 100

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1733551943  29 PILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMDRL 67
Cdd:cd17622    73 PILLLTALDSDIDHILGLELGADDYVVKPVEPAVLLARL 111

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLE-SGLRPCPILFLSANDTAQDMLRGLECGGDDFLLKGGDLAHLMD 65
Cdd:cd17580    45 VILSDIGMPGMDGYELARRLRElPWLANTPAIALTGYGQPEDRERALEAGFDAHLVKPVDPDELIE 110

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

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gi 1733551943   2 IVSDVEMPDMSGHAMVTRL-LESGLrpcPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd17584    48 VITDVHMPDMDGFEFLELIrLEMDL---PVIMMSADGSTSTVMKGLAHGACDYLLK 100

chemotaxis-specific protein-glutamate methyltransferase CheB;

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gi 1733551943   2 IVSDVEMPDMSGHAMVTRLLEsgLRPCPILFLSA--NDTAQDMLRGLECGGDDFLLK 56
Cdd:PRK00742   53 ITLDVEMPVMDGLDALEKIMR--LRPTPVVMVSSltERGAEITLRALELGAVDFVTK 107

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

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                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1733551943   1 MIVSDVEMPDMSGHAMVTRLLESGLRpCPILFLSANDTAQDMLRGLECGGDDFLLK 56
Cdd:cd19931    47 LILLDLNMKGMSGLDTLKALREEGVS-ARIVILTVSDAEDDVVTALRAGADGYLLK 101