NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|589189793|gb|EXG34809|]
View 

bacterial regulatory s, tetR family protein [Acinetobacter baumannii 121738]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
9-157 1.98e-16

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 73.01  E-value: 1.98e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189793   9 RPKDLEKRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLFIcAITETCEETLGTKPFELDASADFY 88
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLL-AVLERLLEELLAALEEALAAEDPR 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 589189793  89 QTLYMVCSRALQIIYSPEALKLehVLFELAAEQSPLAlQFFDASHTRLQNQLVEFFQKAAQLGFIQADD 157
Cdd:COG1309   80 ERLRALLRAYLEFLAENPALAR--LLLAEAAELPELR-AALRALLRRLRALLAELLRAGGLLADVDPDA 145
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
9-157 1.98e-16

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 73.01  E-value: 1.98e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189793   9 RPKDLEKRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLFIcAITETCEETLGTKPFELDASADFY 88
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLL-AVLERLLEELLAALEEALAAEDPR 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 589189793  89 QTLYMVCSRALQIIYSPEALKLehVLFELAAEQSPLAlQFFDASHTRLQNQLVEFFQKAAQLGFIQADD 157
Cdd:COG1309   80 ERLRALLRAYLEFLAENPALAR--LLLAEAAELPELR-AALRALLRRLRALLAELLRAGGLLADVDPDA 145
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
19-62 2.16e-10

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 53.95  E-value: 2.16e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 589189793   19 ILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLF 62
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELL 44
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 13-68 6.38e-09

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 53.86  E-value: 6.38e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 589189793  13 LEKRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLF--ICAITE 68
Cdd:PRK10668  10 QETRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFseIWELSE 67
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
16-61 1.57e-08

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 52.21  E-value: 1.57e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 589189793  16 RARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANL 61
Cdd:NF041196   8 RRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEAL 53
DHAK_reg TIGR02366
probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from ...
 19-94 6.18e-04

probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from a set of closely related uncharacterized proteins associated with operons for the type of bacterial dihydroxyacetone kinase that transfers PEP-derived phosphate from a phosphoprotein, as in phosphotransferase system transport, rather than from ATP. Members have a TetR transcriptional regulator domain (pfam00440) at the N-terminus and sequence homology throughout.


Pssm-ID: 274100 [Multi-domain]  Cd Length: 176  Bit Score: 38.98  E-value: 6.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189793   19 ILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANL----FICAITETCEETLGTKP---------FELDASA 85
Cdd:TIGR02366   8 IAKAFKDLMEVQAFHKISVSDIMQTAQIRRQTFYNHFQDKYELlswiFETELKEQVIDNLDYISwqnildlllRYFDENQ 87


                  ....*....
gi 589189793   86 DFYQTLYMV 94
Cdd:TIGR02366  88 TFYQKAFVI 96
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
9-157 1.98e-16

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 73.01  E-value: 1.98e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189793   9 RPKDLEKRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLFIcAITETCEETLGTKPFELDASADFY 88
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLL-AVLERLLEELLAALEEALAAEDPR 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 589189793  89 QTLYMVCSRALQIIYSPEALKLehVLFELAAEQSPLAlQFFDASHTRLQNQLVEFFQKAAQLGFIQADD 157
Cdd:COG1309   80 ERLRALLRAYLEFLAENPALAR--LLLAEAAELPELR-AALRALLRRLRALLAELLRAGGLLADVDPDA 145
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
19-62 2.16e-10

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 53.95  E-value: 2.16e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 589189793   19 ILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLF 62
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELL 44
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 13-68 6.38e-09

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 53.86  E-value: 6.38e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 589189793  13 LEKRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLF--ICAITE 68
Cdd:PRK10668  10 QETRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFseIWELSE 67
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
16-61 1.57e-08

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 52.21  E-value: 1.57e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 589189793  16 RARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANL 61
Cdd:NF041196   8 RRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEAL 53
TetR_C_7 pfam14246
AefR-like transcriptional repressor, C-terminal domain; This family comprises the C-terminal ...
 99-206 3.17e-08

AefR-like transcriptional repressor, C-terminal domain; This family comprises the C-terminal domain of transcriptional regulators of the TetR family. It includes the AefR transcriptional regulator from P. syringae. It is found in association with pfam00440.


Pssm-ID: 433807  Cd Length: 119  Bit Score: 50.25  E-value: 3.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189793   99 LQIIYSPEALKLEHVLFElAAEQSP-LALQFFDASHTRLQNQLVEFFQKAAQLGFIQADDPLYQTELLLTLLLGVRHHKV 177
Cdd:pfam14246  11 LALLTSPDGIALFRLVIA-EAERFPeLGRAFYEAGPGRGLEALADYLEAAVAAGRLRIDDPELAAEQFLGLLKGFLFWPR 89

                          90       100
                  ....*....|....*....|....*....
gi 589189793  178 LLRIIPVPNAQEIDRFIRDAIDLFLLRYR 206
Cdd:pfam14246  90 LFGGDPPPSPAEIDRVVDSAVDMFLAAYG 118
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
9-145 2.96e-06

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 45.70  E-value: 2.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189793   9 RPKDLEKRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLfICAITETCEETLGTKPFELDASADfy 88
Cdd:COG3226    3 RRRGEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDEL-LAAAFERLAEREAARLRALLAAAD-- 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 589189793  89 qTLYMVCSRALQIIY-----SPEALKLEHVLFELAAEQSPLAlQFFDASHTRLQNQLVEFFQ 145
Cdd:COG3226   80 -DLEDAAEALADLLAellpaDRDRLLARYELYLEALRDPELR-ALLRRWRDRLREALARLLA 139
PRK14996 PRK14996
TetR family transcriptional regulator; Provisional
 14-63 2.77e-05

TetR family transcriptional regulator; Provisional


Pssm-ID: 184958 [Multi-domain]  Cd Length: 192  Bit Score: 43.16  E-value: 2.77e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 589189793  14 EKRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQD----KANLFI 63
Cdd:PRK14996   8 ERREVILQAAMRVALAEGFAAMTVRRIASEAQVAAGQVHHHFSSagelKALAFI 61
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 13-62 8.30e-05

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 42.03  E-value: 8.30e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 589189793  13 LEKRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLF 62
Cdd:PRK09975  10 LKTRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLF 59
DHAK_reg TIGR02366
probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from ...
 19-94 6.18e-04

probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from a set of closely related uncharacterized proteins associated with operons for the type of bacterial dihydroxyacetone kinase that transfers PEP-derived phosphate from a phosphoprotein, as in phosphotransferase system transport, rather than from ATP. Members have a TetR transcriptional regulator domain (pfam00440) at the N-terminus and sequence homology throughout.


Pssm-ID: 274100 [Multi-domain]  Cd Length: 176  Bit Score: 38.98  E-value: 6.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189793   19 ILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANL----FICAITETCEETLGTKP---------FELDASA 85
Cdd:TIGR02366   8 IAKAFKDLMEVQAFHKISVSDIMQTAQIRRQTFYNHFQDKYELlswiFETELKEQVIDNLDYISwqnildlllRYFDENQ 87


                  ....*....
gi 589189793   86 DFYQTLYMV 94
Cdd:TIGR02366  88 TFYQKAFVI 96
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 15-63 7.42e-04

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 39.14  E-value: 7.42e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 589189793  15 KRARILQAAKAIFLKSGYHGTSMNLIAQEAGVTKLTVYNHFQDKANLFI 63
Cdd:PRK15008  19 KKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYI 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH