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Conserved domains on  [gi|589189267|gb|EXG34304|]
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response regulator [Acinetobacter baumannii 121738]

Protein Classification

ANTAR domain-containing response regulator( domain architecture ID 11467116)

response regulator with a signal receiver (REC) domain and RNA binding antiterminator (ANTAR) domain involved in transcriptional antitermination, similar to Mycobacterium tuberculosis transcriptional regulatory protein pdtaR that is a member of the two-component regulatory system pdtaR/pdtaS

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-191 1.23e-55

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 174.76  E-value: 1.23e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   1 MPKLKIALIDDDHARADYIKNSLLENDFEVVACLTLDHLNIFRLEDLQADVILLDMDHPHRDIIESC---VSSYDLPTVL 77
Cdd:COG3707    1 MRGLRVLVVDDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAArqiSEERPAPVIL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267  78 FTKNSDKDTIKQAIDAGVTAYIVDGIDPARLHTILEISIEQYKKHKKLEGDLKEAQTKLADRKDVEKAKVLLMQLHGLPE 157
Cdd:COG3707   81 LTAYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLSE 160

                        170       180       190
                 ....*....|....*....|....*....|....
gi 589189267 158 DTAFQLLRKNAMSHRITIGEMARRLLDAQKLLND 191
Cdd:COG3707  161 DEAYRLLRKQAMDRRVKLAEVAEAILAAAELLKG 194
 
Name Accession Description Interval E-value
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-191 1.23e-55

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 174.76  E-value: 1.23e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   1 MPKLKIALIDDDHARADYIKNSLLENDFEVVACLTLDHLNIFRLEDLQADVILLDMDHPHRDIIESC---VSSYDLPTVL 77
Cdd:COG3707    1 MRGLRVLVVDDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAArqiSEERPAPVIL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267  78 FTKNSDKDTIKQAIDAGVTAYIVDGIDPARLHTILEISIEQYKKHKKLEGDLKEAQTKLADRKDVEKAKVLLMQLHGLPE 157
Cdd:COG3707   81 LTAYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLSE 160

                        170       180       190
                 ....*....|....*....|....*....|....
gi 589189267 158 DTAFQLLRKNAMSHRITIGEMARRLLDAQKLLND 191
Cdd:COG3707  161 DEAYRLLRKQAMDRRVKLAEVAEAILAAAELLKG 194
ANTAR smart01012
ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found ...
 129-183 3.24e-15

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; The majority of the domain consists of a coiled-coil.


Pssm-ID: 198080 [Multi-domain]  Cd Length: 55  Bit Score: 66.73  E-value: 3.24e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 589189267   129 LKEAQTKLADRKDVEKAKVLLMQLHGLPEDTAFQLLRKNAMSHRITIGEMARRLL 183
Cdd:smart01012   1 LEQLREALESRKVIEQAKGILMERRGLSEEEAFELLRKLAMDRNVKLRDVAEAIV 55
ANTAR pfam03861
ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding ...
 135-180 7.51e-13

ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.


Pssm-ID: 427550 [Multi-domain]  Cd Length: 46  Bit Score: 60.04  E-value: 7.51e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 589189267  135 KLADRKDVEKAKVLLMQLHGLPEDTAFQLLRKNAMSHRITIGEMAR 180
Cdd:pfam03861   1 ALESRKVIEQAKGILMERLGLSEDEAFRLLRKLSMDRNVKLREVAE 46
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 6-110 3.91e-06

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 44.04  E-value: 3.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   6 IALIDDDHARADYIKNSL-LENDFEVVA-CLTLDHLnIFRLEDLQADVILLDMDHPHRDIIESCV----SSYDLPTVLFT 79
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLeSEPDIEVVGeAADGEEA-LALLRELRPDVVLMDLSMPGMDGIEALRrlrrRYPDLKVIVLT 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 589189267  80 KNSDKDTIKQAIDAGVTAYIVDGIDPARLHT 110
Cdd:cd17535   80 AHDDPEYVLRALKAGAAGYLLKDSSPEELIE 110
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
7-65 4.66e-03

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 36.41  E-value: 4.66e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 589189267   7 ALIDDDH--ARADyIKNSLLENDFEVVACLTLDHLNIFRLEDLQADVILLDMDHPHRDIIE 65
Cdd:PRK09958   3 AIIIDDHplAIAA-IRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQ 62
 
Name Accession Description Interval E-value
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-191 1.23e-55

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 174.76  E-value: 1.23e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   1 MPKLKIALIDDDHARADYIKNSLLENDFEVVACLTLDHLNIFRLEDLQADVILLDMDHPHRDIIESC---VSSYDLPTVL 77
Cdd:COG3707    1 MRGLRVLVVDDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAArqiSEERPAPVIL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267  78 FTKNSDKDTIKQAIDAGVTAYIVDGIDPARLHTILEISIEQYKKHKKLEGDLKEAQTKLADRKDVEKAKVLLMQLHGLPE 157
Cdd:COG3707   81 LTAYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLSE 160

                        170       180       190
                 ....*....|....*....|....*....|....
gi 589189267 158 DTAFQLLRKNAMSHRITIGEMARRLLDAQKLLND 191
Cdd:COG3707  161 DEAYRLLRKQAMDRRVKLAEVAEAILAAAELLKG 194
ANTAR smart01012
ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found ...
 129-183 3.24e-15

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; The majority of the domain consists of a coiled-coil.


Pssm-ID: 198080 [Multi-domain]  Cd Length: 55  Bit Score: 66.73  E-value: 3.24e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 589189267   129 LKEAQTKLADRKDVEKAKVLLMQLHGLPEDTAFQLLRKNAMSHRITIGEMARRLL 183
Cdd:smart01012   1 LEQLREALESRKVIEQAKGILMERRGLSEEEAFELLRKLAMDRNVKLRDVAEAIV 55
ANTAR pfam03861
ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding ...
 135-180 7.51e-13

ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.


Pssm-ID: 427550 [Multi-domain]  Cd Length: 46  Bit Score: 60.04  E-value: 7.51e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 589189267  135 KLADRKDVEKAKVLLMQLHGLPEDTAFQLLRKNAMSHRITIGEMAR 180
Cdd:pfam03861   1 ALESRKVIEQAKGILMERLGLSEDEAFRLLRKLSMDRNVKLREVAE 46
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 2-128 1.51e-09

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 56.13  E-value: 1.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   2 PKLKIALIDDDHARADYIKNSLLENDFEVVACLTLDHLnIFRLEDLQADVILLDMDHPHRDIIESC----VSSYDLPTVL 77
Cdd:COG2204    1 SMARILVVDDDPDIRRLLKELLERAGYEVETAASGEEA-LALLREEPPDLVLLDLRMPGMDGLELLrelrALDPDLPVIL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 589189267  78 FTKNSDKDTIKQAIDAGVTAYIVDGIDPARLHTILEISIEQYKKHKKLEGD 128
Cdd:COG2204   80 LTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLRRENAED 130
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 6-113 5.65e-09

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 51.77  E-value: 5.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267    6 IALIDDDHARADYIKNSLLENDFEVVACLTLDHLnIFRLEDLQADVILLDMDHPHRDIIESC----VSSYDLPTVLFTKN 81
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEA-LELLKEERPDLILLDINMPGMDGLELLkrirRRDPTTPVIILTAH 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 589189267   82 SDKDTIKQAIDAGVTAYIVDGIDPARLHTILE 113
Cdd:pfam00072  80 GDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 2-144 1.08e-08

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 52.86  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   2 PKLKIALIDDDHARADYIKNSLLENDFEVVACLT----LDhlnifRLEDLQADVILLDMDHPHRDIIESCV------SSY 71
Cdd:COG3437    5 QAPTVLIVDDDPENLELLRQLLRTLGYDVVTAESgeeaLE-----LLLEAPPDLILLDVRMPGMDGFELLRllradpSTR 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 589189267  72 DLPTVLFTKNSDKDTIKQAIDAGVTAYIVDGIDPARLHTILEISIEQYKKHKKLEgDLKEAQTKLADRKDVEK 144
Cdd:COG3437   80 DIPVIFLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRRLQRELD-DLVLYLKLAAPLHDIGK 151
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 3-114 4.80e-08

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 50.68  E-value: 4.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   3 KLKIALIDDDHARADYIKNSLLENDFEVVACLTLDHLnIFRLEDLQADVILLDMDHPHRDIIESC------VSSYDLPTV 76
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEA-LELLQEHRPDLILLDLEMPDMDGLELCrrlradPRTADIPII 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 589189267  77 LFTKNSDKDTIKQAIDAGVTAYIVDGIDPARLHTILEI 114
Cdd:COG3706   80 FLTALDDEEDRARALEAGADDYLTKPFDPEELLARVDL 117
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 3-112 1.16e-07

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 49.95  E-value: 1.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   3 KLKIALIDDDHARADYIKNSLLENDFEVVACLTLDHLnIFRLEDLQADVILLDMDHPHRDIIESCV----SSYDLPTVLF 78
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEA-LELLEEERPDLILLDLMLPGMDGLEVCRrlraRPSDIPIIML 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 589189267  79 TKNSDKDTIKQAIDAGVTAYIVDGIDP----ARLHTIL 112
Cdd:COG0745   80 TARDDEEDRVRGLEAGADDYLTKPFDPeellARIRALL 117
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-121 7.17e-07

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 46.38  E-value: 7.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   1 MPKLKIALIDDDHARADYIKNSLLENDFEVVACLT----LDHLnifrlEDLQADVILLDMDHPHRD------IIESCVSS 70
Cdd:COG0784    3 LGGKRILVVDDNPDNRELLRRLLERLGYEVTTAEDgaeaLELL-----RAGPPDLILLDINMPGMDglellrRIRALPRL 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 589189267  71 YDLPTVLFTKNSDKDTIKQAIDAGVTAYIVDGIDPARLHTILEISIEQYKK 121
Cdd:COG0784   78 PDIPIIALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARASA 128
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 6-110 3.91e-06

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 44.04  E-value: 3.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   6 IALIDDDHARADYIKNSL-LENDFEVVA-CLTLDHLnIFRLEDLQADVILLDMDHPHRDIIESCV----SSYDLPTVLFT 79
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLeSEPDIEVVGeAADGEEA-LALLRELRPDVVLMDLSMPGMDGIEALRrlrrRYPDLKVIVLT 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 589189267  80 KNSDKDTIKQAIDAGVTAYIVDGIDPARLHT 110
Cdd:cd17535   80 AHDDPEYVLRALKAGAAGYLLKDSSPEELIE 110
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-113 7.34e-06

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 43.80  E-value: 7.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   1 MPKLKIALIDDDHARADYIKNSLLEND-FEVVACLT-----LDHLnifrlEDLQADVILLDMDHPHRDIIESCVS----S 70
Cdd:COG4565    1 MKMIRVLIVEDDPMVAELLRRYLERLPgFEVVGVASsgeeaLALL-----AEHRPDLILLDIYLPDGDGLELLRElrarG 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 589189267  71 YDLPTVLFTKNSDKDTIKQAIDAGVTAYIVDGIDPARLHTILE 113
Cdd:COG4565   76 PDVDVIVITAARDPETVREALRAGVVDYLIKPFTFERLREALE 118
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 5-108 1.66e-05

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 42.37  E-value: 1.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   5 KIALIDDDHARADYIKNSLLENDFEVVACLTLDHLnIFRLEDLQADVILLDMDHPHRDIIESCVS---SYDLPTVLFTKN 81
Cdd:cd17622    2 RILLVEDDPKLARLIADFLESHGFNVVVEHRGDRA-LEVIAREKPDAVLLDIMLPGIDGLTLCRDlrpKYQGPILLLTAL 80

                         90       100
                 ....*....|....*....|....*...
gi 589189267  82 -SDKDTIKqAIDAGVTAYIVDGIDPARL 108
Cdd:cd17622   81 dSDIDHIL-GLELGADDYVVKPVEPAVL 107
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 4-116 3.47e-05

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 41.63  E-value: 3.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   4 LKIALIDDDH-ARADyIKNSLLENDFEVVACLTLDHLNIFRLEDLQADVILLDMDHPHRDIIESC---VSSYDLPTVLFT 79
Cdd:cd19932    1 VRVLIAEDEAlIRMD-LREMLEEAGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAkiiTSENIAPIVLLT 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 589189267  80 KNSDKDTIKQAIDAGVTAYIVDGIDPARLHTILEISI 116
Cdd:cd19932   80 AYSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAI 116
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 8-100 2.84e-04

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 38.75  E-value: 2.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   8 LIDDDHARADYIKNSLLENDFEVVACLTLDHLnIFRLEDLQADVILLDMDHPHRDIIESCV----SSYDLPTVLFTKNSD 83
Cdd:cd00156    2 IVDDDPAIRELLKSLLEREGYEVDTAADGEEA-LELLREERPDLVLLDLMMPGMDGLELLRklreLPPDIPVIVLTAKAD 80

                         90
                 ....*....|....*..
gi 589189267  84 KDTIKQAIDAGVTAYIV 100
Cdd:cd00156   81 EEDAVRALELGADDYLV 97
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 5-108 4.11e-04

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 38.60  E-value: 4.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   5 KIALIDDDHARADYIKNSLLENDFEVVACLTLDH-LNIFRleDLQADVILLDMDHPHRDIIESCV---SSYDLPTVLFTK 80
Cdd:cd17626    2 RILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQaLAAFR--EVRPDLVLLDLMLPGIDGIEVCRqirAESGVPIVMLTA 79

                         90       100
                 ....*....|....*....|....*...
gi 589189267  81 NSDKDTIKQAIDAGVTAYIVDGIDPARL 108
Cdd:cd17626   80 KSDTVDVVLGLESGADDYVAKPFKPKEL 107
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 5-116 5.05e-04

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 38.16  E-value: 5.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   5 KIALIDDDHARADYIKNSLLENDFEVVACLTLDHLNIFRLEDLQADVILLD------MDHphrdiIESC---VSSYDLPT 75
Cdd:cd17534    2 KILIVEDEAIIALDLKEILESLGYEVVGIADSGEEAIELAEENKPDLILMDinlkgdMDG-----IEAAreiREKFDIPV 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 589189267  76 VLFTKNSDKDTIKQAIDAGVTAYIVDGIDPARLHTILEISI 116
Cdd:cd17534   77 IFLTAYSDEETLERAKETNPYGYLVKPFNERELKAAIELAL 117
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 3-133 7.22e-04

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 39.03  E-value: 7.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   3 KLKIALIDDDHARADYIKNsLLEN--DFEVVACLTldhlNIF----RLEDLQADVILLDMDHPHR---DIIESCVSSYDL 73
Cdd:COG3279    1 MMKILIVDDEPLARERLER-LLEKypDLEVVGEAS----NGEealeLLEEHKPDLVFLDIQMPGLdgfELARQLRELDPP 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267  74 PTVLFTKNSDKDTIkQAIDAGVTAYIVDGIDPARLHTILEISIEQYKKHKKLEGDLKEAQ 133
Cdd:COG3279   76 PPIIFTTAYDEYAL-EAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEKD 134
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 8-100 1.97e-03

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 36.45  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   8 LIDDDHARADYIKNSLLENDFEVVAC-LTLDHLNIFRLEDLQADVILLDMDHPHRDI---IESCVSSYDLPTVLFTKNSD 83
Cdd:cd17584    3 VVDDDPTCLAILKRMLLRCGYQVTTCtDAEEALSMLRENKDEFDLVITDVHMPDMDGfefLELIRLEMDLPVIMMSADGS 82

                         90
                 ....*....|....*..
gi 589189267  84 KDTIKQAIDAGVTAYIV 100
Cdd:cd17584   83 TSTVMKGLAHGACDYLL 99
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 5-100 3.48e-03

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 35.52  E-value: 3.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589189267   5 KIALIDDDHARADYIKNSLLEN-DFEVVACLT--LDHLNIFRleDLQADVILLDMDHPHRD---IIESCVSSY-DLPTVL 77
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEaGFEVVGEAEngEEALELLE--EHKPDLVITDINMPGMDgleLLEAIRELDpDTKIII 78

                         90       100
                 ....*....|....*....|...
gi 589189267  78 FTKNSDKDTIKQAIDAGVTAYIV 100
Cdd:COG4753   79 LSGYSDFEYAQEAIKLGADDYLL 101
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
7-65 4.66e-03

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 36.41  E-value: 4.66e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 589189267   7 ALIDDDH--ARADyIKNSLLENDFEVVACLTLDHLNIFRLEDLQADVILLDMDHPHRDIIE 65
Cdd:PRK09958   3 AIIIDDHplAIAA-IRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQ 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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