|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
1-395 |
0e+00 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 773.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 1 MEMKKLGLGTTAIHAGTL-KNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEA 79
Cdd:PRK06234 2 ENIKKMGFATKAIHGGHIgDKQFGSLATPIYQTSTFIFDSAEQGGRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 80 GIAMSSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANP 159
Cdd:PRK06234 82 AVVAASGMGAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 160 NLKIVDLEGVCKVAHT-NPNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKELADQIRFVGLK 238
Cdd:PRK06234 162 TLKVTDIKAISNIAHEnNKECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGKEEFINQVKLFGIK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 239 DMTGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKG 318
Cdd:PRK06234 242 DMTGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFELKG 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 551108686 319 GFEAGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:PRK06234 322 GVEEGKVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQALDLI 398
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
6-395 |
0e+00 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 643.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 6 LGLGTTAIHAGTLK-NLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMS 84
Cdd:COG0626 1 MGPATRAVHAGRDPdPQTGAVSPPIYLTSTFVFPSAEALAARFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 85 SGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIV 164
Cdd:COG0626 81 SGMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 165 DLEGVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKE-LADQIRFVglKDMTGA 243
Cdd:COG0626 161 DIAAIAAIAHAA-GALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEeLAERLRFL--QNALGA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 244 VLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGFEAG 323
Cdd:COG0626 238 VLSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGGREAA 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 551108686 324 KTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:COG0626 318 RRFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
23-393 |
0e+00 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 584.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 23 GTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMGAISSTLWTVLKAGD 102
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEAADLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 103 HVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLEGVCKVAHTNpNTLVI 182
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEH-GALLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 183 VDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTN-KELADQIRFVGLkdMTGAVLGPQEAYYIIRGLKTFE 261
Cdd:cd00614 160 VDNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSgEALIQRLRFLRL--ALGTILSPFDAWLLLRGLKTLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 262 IRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGFEAGKTLLNNLKLCSLAVSLGD 341
Cdd:cd00614 238 LRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGG 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 551108686 342 TETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLE 393
Cdd:cd00614 318 VESLVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
5-395 |
0e+00 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 570.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 5 KLGLGTTAIHAGT-LKNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAM 83
Cdd:TIGR01328 1 RMTFATRAIHAGYpPKDQFGALTPPIYQTSTFVFDSCEQGGNRFAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 84 SSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKI 163
Cdd:TIGR01328 81 SSGMGAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 164 VDLEGVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKELADQIRFVGLKDMTGA 243
Cdd:TIGR01328 161 IDMERVCRDAHSQ-GVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKAELLQQIRMVGIKDMTGS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 244 VLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGFEAG 323
Cdd:TIGR01328 240 VISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFELKGGFAGA 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 551108686 324 KTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:TIGR01328 320 KKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQALDAL 391
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
9-393 |
0e+00 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 563.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 9 GTTAIHAGTLKNL-YGTLAMPIYQTSTFIFDsaeqggrrFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGM 87
Cdd:pfam01053 1 DTLAVHAGQRPDPqTGAVSVPIYLTSTYVFD--------FAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGM 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 88 GAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLE 167
Cdd:pfam01053 73 AAITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 168 GVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTN-KELADQIRFvgLKDMTGAVLG 246
Cdd:pfam01053 153 AIAKLAKKH-GILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNgEELGKELYF--LQNATGAVLS 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 247 PQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGFEAGKTL 326
Cdd:pfam01053 230 PFDAWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKF 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 551108686 327 LNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLE 393
Cdd:pfam01053 310 LDNLKLFSLAVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
7-394 |
0e+00 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 561.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 7 GLGTTAIHAG-TLKNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSS 85
Cdd:PRK07503 9 GFSTRAIHHGyDPLDHGGALVPPVYLTATFAFPTAEYGAECFAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALAS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 86 GMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVD 165
Cdd:PRK07503 89 GMGAITATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVD 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 166 LEGVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKELADQIRFVGLKDMTGAVL 245
Cdd:PRK07503 169 IAAVAEIAHGA-GAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALADRIRLEGLKDMTGAVM 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 246 GPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGFEAGKT 325
Cdd:PRK07503 248 SPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFELKGGIAAGRR 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 551108686 326 LLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLEK 394
Cdd:PRK07503 328 FMNALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALDA 396
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
1-395 |
0e+00 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 548.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 1 MEMKKLGLGTTAIHAG-TLKNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEA 79
Cdd:COG2873 1 MTEKKYGFETLALHAGqEPDPTTGARAVPIYQTTSYVFDDAEHAADLFALKEPGNIYTRIMNPTTDVLEKRIAALEGGVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 80 GIAMSSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANP 159
Cdd:COG2873 81 ALATASGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 160 NLKIVDLEGVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTN-----------KEL 228
Cdd:COG2873 161 ALDVLDIEAIAEIAHEH-GVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVDGgnfdwaangkfPEL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 229 ADQ---------------------IRFVGLKDMtGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKV 287
Cdd:COG2873 240 TEPdpsyhglvyteafgnaafitkARVQLLRDL-GAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 288 YYPGLESHPGYEIAKKQMKD-FGAMISFELKGGFEAGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAG 366
Cdd:COG2873 319 NYPGLPSHPYHELAQKYLPKgAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAG 398
|
410 420
....*....|....*....|....*....
gi 551108686 367 ITDGLVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:COG2873 399 VTPDLIRLSVGIEDIDDIIADLDQALAAA 427
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
3-392 |
1.68e-167 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 474.10 E-value: 1.68e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 3 MKKLGLGTTAIHAGTLKNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIA 82
Cdd:PRK08133 2 DDSLGFDTLAVRAGQLRSPFGEHSEALFLTSSFVFESAAEAAARFAGEEPGNIYSRFTNPTVTMFQERLAALEGAEACVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 83 MSSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLK 162
Cdd:PRK08133 82 TASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 163 IVDLEGVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKELADQIrfVGLKDMTG 242
Cdd:PRK08133 162 LADIAALAEIAHAA-GALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKELMEEV--FGFLRTAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 243 AVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGFEA 322
Cdd:PRK08133 239 PTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVKGGREA 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 323 GKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGL 392
Cdd:PRK08133 319 AWRVIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGL 388
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
3-395 |
7.01e-167 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 472.40 E-value: 7.01e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 3 MKKLGLGTTAIHAG-TLKNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGI 81
Cdd:PRK06767 1 MKKKHMETALIHHGyTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 82 AMSSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNL 161
Cdd:PRK06767 81 AFGSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 162 KIVDLEGVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKELADQIRFVGLKDMt 241
Cdd:PRK06767 161 KLIDLKQVIRVAKRN-GLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDI- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 242 GAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYpgleshPGYEIAKKQMKDFGAMISFELKGGFE 321
Cdd:PRK06767 239 GGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRGGGVISFSIKGGKE 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 551108686 322 AGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:PRK06767 313 ETQAFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALKKI 386
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
10-393 |
9.86e-164 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 465.68 E-value: 9.86e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 10 TTAIHAG-TLKNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMG 88
Cdd:TIGR01326 4 TLQLHAGqEPDPTTGSRAVPIYQTTSYVFDSTEHAAALFGLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVASGQA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 89 AISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLEG 168
Cdd:TIGR01326 84 AITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVLDIEA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 169 VCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVV-------TNKELAD----------- 230
Cdd:TIGR01326 164 IAEVAHRH-GIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVdggkfdwNNGRFPLfttpdpsyhgl 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 231 -------------QIRFVGLKDmTGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPG 297
Cdd:TIGR01326 243 vftetlgnpafilKARVQLLRD-LGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASHPH 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 298 YEIAKKQM-KDFGAMISFELKGGFEAGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSV 376
Cdd:TIGR01326 322 HALAKKYLpKGFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRLSV 401
|
410
....*....|....*..
gi 551108686 377 GLENVEDIIADLEQGLE 393
Cdd:TIGR01326 402 GIENIDDIIADLEQALE 418
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
1-394 |
6.30e-162 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 459.88 E-value: 6.30e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 1 MEMKKLGLGTTAIHAG-TLKNLYGTLAMPIYQTSTFIFDSAeqGGRRfaleeAGYIYTRLGNPTTTVLENKIAALEEGEA 79
Cdd:PRK07811 6 DHHANQGFATRAIHAGyEPDPATGAVNPPIYASSTFAQDGV--GGLR-----GGYEYARTGNPTRTALEEQLAALEGGAY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 80 GIAMSSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANP 159
Cdd:PRK07811 79 GRAFSSGMAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 160 NLKIVDLEGVCKVAHtNPNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTN-KELADQIRFvgLK 238
Cdd:PRK07811 159 LLSITDIAALAELAH-DAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNdEELDEAFAF--LQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 239 DMTGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKG 318
Cdd:PRK07811 236 NGAGAVPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAG 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 551108686 319 GFEAGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREaagITDGLVRLSVGLENVEDIIADLEQGLEK 394
Cdd:PRK07811 316 GEEAARDFCARTKVFTLAESLGGVESLIEHPSAMTHASTAGSQLE---VPDDLVRLSVGIEDVADLLADLEQALGQ 388
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
23-395 |
7.58e-148 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 424.18 E-value: 7.58e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 23 GTLAMPIYQTSTFifdsaeqggRRFALEEAG-YIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMGAISSTLWTvLKAG 101
Cdd:PRK08064 23 GAVNVPIYHASTF---------HQFDFDTFGkYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAISTAFLL-LSKG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 102 DHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLEGVCKVAHTNpNTLV 181
Cdd:PRK08064 93 DHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVKLAKAI-GCLT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 182 IVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGL-VVTNKELADQIRFvgLKDMTGAVLGPQEAYYIIRGLKTF 260
Cdd:PRK08064 172 FVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLaVVKDEELAQKLYF--LQNSFGAVLGVQDCWLVLRGLKTL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 261 EIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELkGGFEAGKTLLNNLKLCSLAVSLG 340
Cdd:PRK08064 250 HVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTL-QSEEAVRQFVSHVKLPVFAVSLG 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 551108686 341 DTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:PRK08064 329 AVESILSYPAKMSHAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALSYV 383
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
10-393 |
7.92e-147 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 421.05 E-value: 7.92e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 10 TTAIHAGTLKNLY-GTLAMPIYQTSTFifdSAEQGGrrfalEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMG 88
Cdd:PRK07671 5 TKLIHGGIIGDPStGAVSVPIYQVSTY---KQEAVG-----KHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 89 AISSTLwTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLEG 168
Cdd:PRK07671 77 AITAVM-MLFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 169 VCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTN-KELADQIRFVglKDMTGAVLGP 247
Cdd:PRK07671 156 ISTIAKEK-GLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNsPELAEDLHFV--QNSTGGILGP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 248 QEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELkGGFEAGKTLL 327
Cdd:PRK07671 233 QDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFDV-GSEETANKVL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 551108686 328 NNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLE 393
Cdd:PRK07671 312 ERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
1-395 |
1.94e-146 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 421.07 E-value: 1.94e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 1 MEMKKLGLGTTAIHAGTLKNL-YGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEA 79
Cdd:PRK08249 2 MDFNNAGVGTKAVWAGEKEYLpYGATQVPVVLSVAYGYDDIDEWYDVALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 80 GIAMSSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANP 159
Cdd:PRK08249 82 ATAFSTGMAAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 160 NLKIVDLEGVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKELADQIRFvgLKD 239
Cdd:PRK08249 162 TLKIVDIERLAAAAKKV-GALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVCGSKELMEQVYH--YRE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 240 MTGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGG 319
Cdd:PRK08249 239 INGATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFVLKGG 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 551108686 320 FEAGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:PRK08249 319 MDTVKRLLPKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAFAHL 394
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
10-392 |
6.42e-143 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 411.55 E-value: 6.42e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 10 TTAIHAGTLKNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMGA 89
Cdd:TIGR01325 2 TLAVRGGMLRSGFEETAEALYLTSGYVYDSAAVAAKRFAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 90 ISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLEGV 169
Cdd:TIGR01325 82 IFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIAAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 170 CKVAHTnPNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKELADQIrFVGLKDMTGAVLGPQE 249
Cdd:TIGR01325 162 AELAHA-AGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSEEYMDEP-VQKLLRHTGPAMSPFN 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 250 AYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGfEAGKTLLNN 329
Cdd:TIGR01325 240 AWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDLDCR-QAAFKVLDA 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 551108686 330 LKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGL 392
Cdd:TIGR01325 319 MRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSVGLEDVDDLIADIDRAL 381
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
10-392 |
6.99e-140 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 405.67 E-value: 6.99e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 10 TTAIHAGTLKN-LYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMG 88
Cdd:PRK07812 16 TKQIHAGQTPDpATNARALPIYQTTSYTFDDTDHAAALFGLAEPGNIYTRIMNPTQDVVEQRIAALEGGVAALLLASGQA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 89 AISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFV-DTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLE 167
Cdd:PRK07812 96 AETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQIDVLDIP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 168 GVCKVAHTNPNTLvIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKELA-DQIRFVG---------- 236
Cdd:PRK07812 176 GVAEVAHEAGVPL-IVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVDGGTFDwTQGRFPGfttpdpsyhg 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 237 -------------------LKDmTGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPG 297
Cdd:PRK07812 255 vvfaelgppayalkarvqlLRD-LGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSPW 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 298 YEIAKKQM-KDFGAMISFELKGGFEAGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSV 376
Cdd:PRK07812 334 YERAKRLApKGTGAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLVRLAV 413
|
410
....*....|....*.
gi 551108686 377 GLENVEDIIADLEQGL 392
Cdd:PRK07812 414 GIEGIDDILADLEAGF 429
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
8-395 |
1.59e-139 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 402.74 E-value: 1.59e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 8 LGTTAIHAGTLKN-LYGTLAMPIYQTSTFIFDSAEQggrrfaleEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSG 86
Cdd:PRK06176 3 MQTKLIHGGISEDtTTGAVSVPIYQTSTYRQDAIGR--------PKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 87 MGAISSTLwTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDL 166
Cdd:PRK06176 75 LAGIHAVF-SLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 167 EGVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTN-KELADQIRFvgLKDMTGAVL 245
Cdd:PRK06176 154 AQCASVAKDH-GLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNnEALAQEIAF--FQNAIGGVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 246 GPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGFEAgKT 325
Cdd:PRK06176 231 GPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKNDSEA-VA 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 326 LLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:PRK06176 310 FVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKI 379
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
1-395 |
1.16e-131 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 384.45 E-value: 1.16e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 1 MEMKKLGLGTTAIHAGTLKN-LYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEA 79
Cdd:PRK05994 1 MTDRSPGFATLAVHAGAQPDpTTGARATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRITNPTNAVLEERVAALEGGTA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 80 GIAMSSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANP 159
Cdd:PRK05994 81 ALAVASGHAAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 160 NLKIVDLEGVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVT--------------- 224
Cdd:PRK05994 161 GGTVTDIAAIAEVAHRA-GLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVDggtfdwsksgkypml 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 225 -----------------NKELADQIRFVGLKDMtGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKV 287
Cdd:PRK05994 240 seprpeyhglvlhetfgNFAFAIAARVLGLRDL-GPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 288 YYPGLESHPGYEIAKKQM-KDFGAMISFELKGGFEAGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAG 366
Cdd:PRK05994 319 NYAGLPDDPYHALAQKYSpKGAGAVFTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAG 398
|
410 420
....*....|....*....|....*....
gi 551108686 367 ITDGLVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:PRK05994 399 AGPDVVRLSIGIEDVDDIIADLEQALAKA 427
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
1-394 |
1.65e-129 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 379.19 E-value: 1.65e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 1 MEMKKLGLGTTAIHAGT-LKNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEA 79
Cdd:PRK08248 2 SEERTFRLETLAIHAGQeIDPTTGSRAVPIYQTTSYGFRDSEHAANLFSLKEFGNIYTRIMNPTTDVFEKRIAALEGGIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 80 GIAMSSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANP 159
Cdd:PRK08248 82 ALAVSSGQAAITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 160 NLKIVDLEGVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKEL--ADQIRFVG- 236
Cdd:PRK08248 162 KGDVLDIEAVAAIAHEH-GIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVDSGKFdwKGSGKFPGl 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 237 -----------------------------LKDMtGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKV 287
Cdd:PRK08248 241 tepdpsyhglvytdavgeaayitkarvqlLRDL-GAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 288 YYPGLESHPGYEIAKKQM-KDFGAMISFELKGGFEAGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAG 366
Cdd:PRK08248 320 SYPGLPSHPSYELAKKYLpKGQGAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAG 399
|
410 420
....*....|....*....|....*...
gi 551108686 367 ITDGLVRLSVGLENVEDIIADLEQGLEK 394
Cdd:PRK08248 400 VTPGLVRLSVGTEAIDDILDDLRQAIRQ 427
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
3-392 |
1.83e-127 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 374.07 E-value: 1.83e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 3 MKKLGLGTTAIHAGTLKN-LYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGI 81
Cdd:PRK08134 4 MSPPGFDTLALHAGAAPDpATGARAVPIHLTTSFVFRDSDHAAALFNLERAGHVYSRISNPTVAVLEERVAALEGGVGAI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 82 AMSSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNL 161
Cdd:PRK08134 84 ATASGQAALHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 162 KIVDLEGVCKVAHTNPNTLvIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTN-----------KELAD 230
Cdd:PRK08134 164 EVLDIPTVAAIAHEAGVPL-LVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGgrfdweasgkfPELTE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 231 ---------------------QIRFVGLKDMtGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYY 289
Cdd:PRK08134 243 pyagfhgmvfaeestvaafllRARREGLRDF-GACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAH 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 290 PGLESHPGYEIAKKQM-KDFGAMISFELKGGFEAGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGIT 368
Cdd:PRK08134 322 PELESHPDHALAKRLLpRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIG 401
|
410 420
....*....|....*....|....
gi 551108686 369 DGLVRLSVGLENVEDIIADLEQGL 392
Cdd:PRK08134 402 EGTIRLSIGLEDADDLIDDLKRAL 425
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
6-395 |
2.19e-125 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 367.08 E-value: 2.19e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 6 LGLGTTAIHAGTLKNLYGTLAMPIYQTSTFIFD-SAEQGGRRFALEeagyiYTRLGNPTTTVLENKIAALEEGEAGIAMS 84
Cdd:PRK08574 1 MRRGTDAVRGYRGSDPYGSLQPPIYLTALFRQEgEAYPSDRGFDLK-----YSREENPTLRPLEEALAKLEGGVDALAFN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 85 SGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHgLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIV 164
Cdd:PRK08574 76 SGMAAISTLFFSLLKAGDRVVLPMEAYGTTLRLLKS-LEKFGVKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 165 DLEGVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVT-NKELADqiRFVGLKDMTGA 243
Cdd:PRK08574 155 DVPEVAKAAKEL-GAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAwSGEFLE--ELWEWRRRLGT 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 244 VLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKD--FGAMISFELKGGFE 321
Cdd:PRK08574 232 IMQPFEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLFGKdlYGGVVSFRVKGGRD 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 551108686 322 AGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:PRK08574 312 AVLKFLRSLKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQALGSI 385
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
10-395 |
7.38e-125 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 366.00 E-value: 7.38e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 10 TTAIHAGTLKNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMGA 89
Cdd:PRK07504 13 TRLVHSGTLRSQFGETSEALFLTQGFVYDTAEAAEARFKGEDPGFIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 90 ISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLEGV 169
Cdd:PRK07504 93 VTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAVRPNTKVFFLESPTNPTLEVIDIAAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 170 CKVAHTNPNTLViVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKE-----LADQIRfvglkdMTGAV 244
Cdd:PRK07504 173 AKIANQAGAKLV-VDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAwieehLQDYFR------HTGPS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 245 LGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGFEAGK 324
Cdd:PRK07504 246 LSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQADIIAKQMTGGSTLVAFELKGGKEAAF 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 551108686 325 TLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:PRK07504 326 RFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAALKKV 396
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
22-395 |
1.42e-124 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 364.89 E-value: 1.42e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 22 YGTLAMPIYQTSTFIFDSAEqggrrfalEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMGAIssTLWTV--LK 99
Cdd:TIGR02080 19 YGCVVPPIYLSTTYNFTGFN--------EPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAI--HLVTTalLG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 100 AGDHVVTDKTLYGCTFALMNhGLTKFGV-EVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLEGVCKVAHTNpN 178
Cdd:TIGR02080 89 PDDLLVAPHDCYGGTYRLLN-ALAKKGCfRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICHLAKAV-G 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 179 TLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVT-NKELADQIRFVGlkDMTGAVLGPQEAYYIIRGL 257
Cdd:TIGR02080 167 AVVVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAkDPQVAEELAWWA--NNLGVTGGAFDSYLTLRGL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 258 KTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGFEAGKTLLNNLKLCSLAV 337
Cdd:TIGR02080 245 RTLVARMRLQQRNAQAIVEYLQTQPLVKKIYYPGLPDHPGHEIAARQQKGFGAMLSFELKGGEQTVRRFLGGLSLFTLAE 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 551108686 338 SLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:TIGR02080 325 SLGGVESLIAHPATMTHAAMGPEARAEAGISDTLLRLSVGLEDADDLIADLEQGLRAA 382
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
9-395 |
5.47e-124 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 363.00 E-value: 5.47e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 9 GTTAIHAGTlKNLYGTLAMPIYQTSTFIFDSAEQggrrfaleeagYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMG 88
Cdd:PRK06460 4 ATRTVREDI-DEATGAITTPIYQTTAYHYPEGEK-----------YRYSREANPTVLELTKKIVELENAEMGVAFSSGMG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 89 AISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLEG 168
Cdd:PRK06460 72 AISTTALALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITE 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 169 VCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKELADQIRFvgLKDMTGAVLGPQ 248
Cdd:PRK06460 152 LSKVCKEN-GSILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGKLLNVIDQ--MRRTLGTSLDPH 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 249 EAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGFEAGKTLLN 328
Cdd:PRK06460 229 AAYLTLRGIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFEVNGGQESALKVMK 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 551108686 329 NLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:PRK06460 309 SLKLIIPAQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRALSTL 375
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
6-392 |
5.58e-119 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 351.34 E-value: 5.58e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 6 LGLGTTAIHAGTLKNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSS 85
Cdd:PRK07810 14 VSQATIGVRGGLLRSGFEETAEALYLTSGYVYESAAAAEAAFTGELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 86 GMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVD 165
Cdd:PRK07810 94 GMSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVD 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 166 LEGVCKVAHTnPNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKELADQiRFVGLKDMTGAVL 245
Cdd:PRK07810 174 IAAVSELAHA-AGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDREYIDG-PVQKLMRHTGPAL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 246 GPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGFEAGK- 324
Cdd:PRK07810 252 SAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFELDAPEDAAKk 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 551108686 325 ---TLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGL 392
Cdd:PRK07810 332 rafEVLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLDRAL 402
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
23-395 |
8.04e-118 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 347.07 E-value: 8.04e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 23 GTLAMPIYQTSTFifdsaeqgGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMGAISsTLWTVLKAGD 102
Cdd:PRK08247 21 GTVNPPVYFSTAY--------RHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQ-LVMSLFRSGD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 103 HVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLEGVCKVAHTNpNTLVI 182
Cdd:PRK08247 92 ELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIAKKH-GLLLI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 183 VDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTN-KELADQIRFvgLKDMTGAVLGPQEAYYIIRGLKTFE 261
Cdd:PRK08247 171 VDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKgQELCERLAY--YQNAAGAVLSPFDSWLLIRGMKTLA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 262 IRMERHCKNARTIADFLNKHPKVEKVYYPGLeshpgyeiakkqmkdfGAMISFELKGGfEAGKTLLNNLKLCSLAVSLGD 341
Cdd:PRK08247 249 LRMRQHEENAKAIAAFLNEQPGVTDVLYPGR----------------GGMLSFRLQDE-EWVNPFLKSLKLITFAESLGG 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 551108686 342 TETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:PRK08247 312 VESFITYPATQTHADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFKQV 365
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
8-392 |
9.13e-117 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 344.89 E-value: 9.13e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 8 LGTTAIHAGTLKNLYGTLAMPIYQTSTFIFDSAEQGGRrfaleeagYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGM 87
Cdd:TIGR01329 1 LSTLLVNTDNKNDPYDASSMPIYQTATFKQPLAIENGP--------YDYTRSGNPTRTALESLLAKLDKADRAFAFSSGM 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 88 GAISsTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLE 167
Cdd:TIGR01329 73 AALD-VITRLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 168 GVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTN-KELADQIRFvgLKDMTGAVLG 246
Cdd:TIGR01329 152 KISEMAHAQ-NALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKgEEIAKKVYF--LQNSTGSGLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 247 PQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFElKGGFEAGKTL 326
Cdd:TIGR01329 229 PFDCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKGAGSVLSFE-TGSVALSKRL 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 551108686 327 LNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGL 392
Cdd:TIGR01329 308 VEATKLFSITVSFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAF 373
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
4-395 |
8.70e-114 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 338.96 E-value: 8.70e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 4 KKLGLGTTAIHAGTLKNLYG--------TLAMPIYQTSTFIFDSAEQGGRRF----------ALEEAGYIYTRLGNPTTT 65
Cdd:PRK07049 7 SKTHIGNRELHPETQMLNYGydpelsegAVKPPVFLTSTFVFRSAEDGRDFFdyvsgrkeppAGEGAGLVYSRFNHPNSE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 66 VLENKIAALEEGEAGIAMSSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVE-VTFVDTSNLDEVKKAM 144
Cdd:PRK07049 87 IVEDRLAVYEGAESAALFSSGMSAIATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGaVGFADGLSEAAIGAAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 145 KE-----NTRVVYLETPANPNLKIVDLEGVCKVAHT-------NPntLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLN 212
Cdd:PRK07049 167 EAaaakgRVSLILIETPANPTNSLVDVAAVRRVADAiearqghRP--IIACDNTLLGPVFQKPLEHGADLSVYSLTKYVG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 213 GHGDVIAGLVVTNKELADQIRfvGLKDMTGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPG- 291
Cdd:PRK07049 245 GHSDLVAGAVLGRKALIRQVR--ALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPf 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 292 LESHPGY-EIAKKQMKDFGAMISFELKGGFEAGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDG 370
Cdd:PRK07049 323 LDPDSAYgAVYKRQCTGAGSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLES 402
|
410 420
....*....|....*....|....*
gi 551108686 371 LVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:PRK07049 403 TIRLSIGIEHPDDLIADLAQALDAA 427
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
7-394 |
1.38e-113 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 336.87 E-value: 1.38e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 7 GLGTTAIHAGTLKN-LYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSS 85
Cdd:PRK06434 8 GFNTRAVQSGELRDpRFGNVTTPIFETSTFVYPNSEKEAYMDSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 86 GMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKeNTRVVYLETPANPNLKIVD 165
Cdd:PRK06434 88 GMGAITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRLNSLDFDPS-NYDLIYAESITNPTLKVPD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 166 LEGVCKVAHTNpntLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTN-KELADQIrfVGLKDMTGAV 244
Cdd:PRK06434 167 IKNVSSFCHEN---DVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNnKSIFNNL--VERRKTLGSN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 245 LGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLeshpgyEIAKKQMKDFGAMISFELKGGFEAGK 324
Cdd:PRK06434 242 PDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKVLRGFGGMLSFELRSMEDVHK 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 325 tLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLEK 394
Cdd:PRK06434 316 -FIRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENALSK 384
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
22-393 |
1.82e-113 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 337.05 E-value: 1.82e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 22 YGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMGAISSTLWTVLKAG 101
Cdd:PRK05939 7 HGAVHKPIHTSVTYGYEDARDLIDVFQGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 102 DHVVTDKTLYGCTFALMNhGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLEGVCKVAHTNpNTLV 181
Cdd:PRK05939 87 DHLVSSQFLFGNTNSLFG-TLRGLGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRER-GLLY 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 182 IVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGlVVTNKELAD----------------------QIRFVGLKD 239
Cdd:PRK05939 165 VVDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGG-AVTDTGLFDwsaypnifpayrkgdpqqwgltQIRKKGLRD 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 240 MtGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGG 319
Cdd:PRK05939 244 M-GATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELADG 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 551108686 320 ---FEagktLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLE 393
Cdd:PRK05939 323 idcFD----FLNRLKLVIKATHLGDTRTLVIPVAPTIYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALD 395
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
10-394 |
2.66e-111 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 331.95 E-value: 2.66e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 10 TTAIHAGTLKNL-YGTLAMPIYQTSTFIFDSAeqGGRRfaleeaGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMG 88
Cdd:PRK08776 15 TAAVRAGIDRDTaYGAVTPPIVLSSNFSFDGF--GNKR------QYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 89 AISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLEG 168
Cdd:PRK08776 87 AINLVLNALLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 169 VCKVAHtNPNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVT-NKELADQIrfVGLKDMTGAVLGP 247
Cdd:PRK08776 167 VIEAAH-KVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVArDAELHQQL--VWWANALGLTGSP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 248 QEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGFEAGKTLL 327
Cdd:PRK08776 244 FDAFLTLRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFELEGGEAAVRAFV 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 551108686 328 NNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLEK 394
Cdd:PRK08776 324 DGLRYFTLAESLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDLRAGLAR 390
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
8-393 |
8.75e-110 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 328.40 E-value: 8.75e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 8 LGTTAIHAG-----TLKnlygTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIA 82
Cdd:PRK06084 3 LETLAIHAGyspdpTTK----AVAVPIYQTTSYAFDDTQHGADLFDLKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 83 MSSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLK 162
Cdd:PRK06084 79 VASGMAAITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 163 IVDLEGVCKVAHTNPNTLvIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKEL---ADQIRF----- 234
Cdd:PRK06084 159 IIDIQALADAAHRHGVPL-IVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKFpwaEHKERFallnt 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 235 -------------------------VGLKDMtGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYY 289
Cdd:PRK06084 238 pdpsyhgvtyteafgpaafigrcrvVPLRNM-GAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 290 PGLESHPGYEIAKKQMKDF-GAMISFELKGGFEAGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGIT 368
Cdd:PRK06084 317 AGLPDHPEHELARRYMGGKpASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVS 396
|
410 420
....*....|....*....|....*
gi 551108686 369 DGLVRLSVGLENVEDIIADLEQGLE 393
Cdd:PRK06084 397 RDMVRLSIGIEHIDDIIADLAQALD 421
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
7-395 |
1.80e-109 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 328.37 E-value: 1.80e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 7 GLGTTAIHAG-TLKNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSS 85
Cdd:PRK05613 13 GFETRSIHAGqSVDSDTSARNLPIYQTTSYVFDSAEHAKQRFALEDLGPIYSRLTNPTVEALENRIASLEGGVHAVAFAS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 86 GMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEV-KKAMKENTRVVYLETPANPNLKIV 164
Cdd:PRK05613 93 GQAAETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVENPDDPESwQAAVQPNTKAFFGETFANPQADVL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 165 DLEGVCKVAHTNPNTLvIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKEL---------------- 228
Cdd:PRK05613 173 DIPAVAEVAHRNQVPL-IVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGKFdwtverdgkpvfpyfv 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 229 -----------AD--------QIRfVGLKDMTGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYY 289
Cdd:PRK05613 252 tpdpayhglkyADlgapafglKAR-AGLLRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNF 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 290 PGLESHPGYEIAKK-QMKDFGAMISFELKGGFEAGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGIT 368
Cdd:PRK05613 331 AGLKDSPWYATKEKlGLKYTGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGIT 410
|
410 420
....*....|....*....|....*..
gi 551108686 369 DGLVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:PRK05613 411 QATVRLSVGIEDIDDIIADLEGGFAAI 437
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
22-393 |
1.60e-105 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 316.45 E-value: 1.60e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 22 YGTLAMPIYQTSTFIFDSAEQggrrfaleEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMGAISSTLWTVLKAG 101
Cdd:PRK08045 20 YGCVVPPIHLSSTYNFTGFNE--------PRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 102 DHVVTDKTLYGCTFALMNhGLTKFGV-EVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLEGVCKVAHTnPNTL 180
Cdd:PRK08045 92 DLLVAPHDCYGGSYRLFD-SLAKRGCyRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLARE-AGAV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 181 VIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVT-NKELADQIRFVGlkDMTGAVLGPQEAYYIIRGLKT 259
Cdd:PRK08045 170 SVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAkDPDVVTELAWWA--NNIGVTGGAFDSYLLLRGLRT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 260 FEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGFEAGKTLLNNLKLCSLAVSL 339
Cdd:PRK08045 248 LVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAESL 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 551108686 340 GDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLE 393
Cdd:PRK08045 328 GGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFR 381
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
22-394 |
1.81e-103 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 311.06 E-value: 1.81e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 22 YGTLAMPIYQTSTFIFDSaeqggrrFAlEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMGAISSTLWTVLKAG 101
Cdd:PRK08861 21 YHAVVPPIYLSTNYGFPA-------FG-EVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLWVSALLGPD 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 102 DHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLEGVCKVAHtNPNTLV 181
Cdd:PRK08861 93 DLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQKAK-AVGALV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 182 IVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVT-NKELADQIRFVGlkDMTGAVLGPQEAYYIIRGLKTF 260
Cdd:PRK08861 172 AVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITkTKEHAEELAWWG--NCIGATGTPFDSYMTLRGIRTL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 261 EIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGFEAGKTLLNNLKLCSLAVSLG 340
Cdd:PRK08861 250 GARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFAGSFEQLKVFVKALALFSLAESLG 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 551108686 341 DTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLEK 394
Cdd:PRK08861 330 GVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAFAK 383
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
22-392 |
1.86e-102 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 311.19 E-value: 1.86e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 22 YGTLAMPIYQTSTFIFDSAeqggrrfaLEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMGAISSTLwTVLKAG 101
Cdd:PLN02509 101 FDAMSTPLYQTATFKQPSA--------IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVT-HLIKNG 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 102 DHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLEGVCKVAHTNpNTLV 181
Cdd:PLN02509 172 EEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQ-GALV 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 182 IVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAG-LVVTNKELADQIRFvgLKDMTGAVLGPQEAYYIIRGLKTF 260
Cdd:PLN02509 251 LVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGvLAVKGEKLAKEVYF--LQNSEGSGLAPFDCWLCLRGIKTM 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 261 EIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFeLKGGFEAGKTLLNNLKLCSLAVSLG 340
Cdd:PLN02509 329 ALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFG 407
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 551108686 341 DTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGL 392
Cdd:PLN02509 408 SVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 459
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
20-394 |
7.04e-98 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 296.99 E-value: 7.04e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 20 NLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMGAISSTLWTVLK 99
Cdd:PRK05968 21 NAFDAVVPPIFQTSLFTFDSYDEMEDVYAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAISSTVLSFVE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 100 AGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKeNTRVVYLETPANPNLKIVDLEGVCKVAHTNpNT 179
Cdd:PRK05968 101 PGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKALP-GAKLLYLESPTSWVFELQDVAALAALAKRH-GV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 180 LVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKELADQIRFVGLKdMTGAVLGPQEAYYIIRGLKT 259
Cdd:PRK05968 179 VTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIARINAEAYP-YLGAKLSPFEAWLLLRGLRT 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 260 FEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPgyeiaKKQMKDFGAMISFELKGGFEAgKTLLNNLKLCSLAVSL 339
Cdd:PRK05968 258 LPLRMKAHEASALEIARRLKAHPVVERVCHPALANHP-----PAGLSGTSGLFSFIFREGIDV-RAFADALKLFRLGVSW 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 551108686 340 GDTETLIQhPASMTHSPYTKEEREAA-GITDGLVRLSVGLENVEDIIADLEQGLEK 394
Cdd:PRK05968 332 GGHESLVV-PAEVVLQQKAQPNSAARfGVSPRSVRLHVGLEGTEALWADLEQALAA 386
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
7-392 |
1.17e-97 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 295.37 E-value: 1.17e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 7 GLGTTAIHAGTLKNLYGT-LAMPIYQTSTFIFDSAEQGGrrfaleeaGYIYTRLGNPTTTVLENKIAALEEGEAgIAMSS 85
Cdd:PRK07582 3 GDGTRSVHAGGPEAVPGEpVLPGPVFAAPYHLSPGEPTG--------PDTYGRASNPTWRALEAALGELEGAEA-LVFPS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 86 GMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEvkkAMKENTRVVYLETPANPNLKIVD 165
Cdd:PRK07582 74 GMAAITAVLRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREAPTAGMAE---AALAGADLVLAETPSNPGLDVCD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 166 LEGVCKVAHtNPNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVT-NKELADQIRfvGLKDMTGAV 244
Cdd:PRK07582 151 LAALAAAAH-AAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGrDPELMAAVE--RWRLLAGAI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 245 LGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELkGGFEAGK 324
Cdd:PRK07582 228 PGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFEL-ADAAAAE 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 325 TLLNNLKLCSLAVSLGDTETliqhpasmthspyTKEEREAAG--ITDGLVRLSVGLENVEDIIADLEQGL 392
Cdd:PRK07582 307 RFVAASRLVVAATSFGGVHT-------------SADRRARWGdaVPEGFVRLSCGIEDTDDLVADLERAL 363
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
3-393 |
6.61e-91 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 278.24 E-value: 6.61e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 3 MKKLGLGTTAIHAGTLKN-LYGTLAMPIYQTSTFifDSAEQGgrrfalEEAGYIYTRLGNPTTTVLENKIAALEEGEAGI 81
Cdd:PRK07269 2 SKDLHINTILAQAGIKSDeATGALVTPLHFSTTY--QHPEFG------QSTGFDYTRTKNPTRAKLEETLAAIESADYAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 82 AMSSGMGAISsTLWTVLKAGDHVVTDKTLYGCTFALMNHGlTKFGvEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNL 161
Cdd:PRK07269 74 ATSSGMSAIV-LAFSVFPVGSKVVAVRDLYGGSFRWFNQQ-EKEG-RFHFTYANTEEELIAAIEEDTDIVYIETPTNPLM 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 162 KIVDLEGVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTN-KELADQIrFVGLkDM 240
Cdd:PRK07269 151 VEFDIEKVAKLAHAK-GAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNdLELYEKL-FYNL-NT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 241 TGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLeshpgyeiakkqmkdfGAMISFELkggF 320
Cdd:PRK07269 228 TGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGK----------------GGMISFKV---A 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 551108686 321 EAGK--TLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVGLENVEDIIADLEQGLE 393
Cdd:PRK07269 289 DETRipHILNSLKVFTFAESLGGVESLITYPTTQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQALE 363
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
22-377 |
2.36e-85 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 265.86 E-value: 2.36e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 22 YGTLAMPIYQTSTFIFDSAEQGGRRFALE---EAG-YIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMGAISSTLWTV 97
Cdd:PLN02242 32 HGGVNMSIEASATFTVMEPDTMRRMFSGElgpDRDfYIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 98 LKAGDHVVTDKTLYGCTFALMNHGL-TKFGVEVTFVDTSNLDEVKKAMKEN-TRVVYLETPANPNLKIVDLEGVCKVAHT 175
Cdd:PLN02242 112 CSSGGHVVASNTLYGGTHALLAHFLpRKCNITTTFVDITDLEAVKKAVVPGkTKVLYFESISNPTLTVADIPELARIAHE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 176 NPNTLViVDNTFAtPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKELADQIRfvGLKD----MTGAVLGPQEAY 251
Cdd:PLN02242 192 KGVTVV-VDNTFA-PMVLSPARLGADVVVHSISKFISGGADIIAGAVCGPAELVNSMM--DLHHgalmLLGPTMNPKVAF 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 252 YIIRGLKTFEIRMERHCKNARTIADFLNKHPKveKVYYPGLESHPGYEIAKKQMKD---FGAMISFELkGGFEAGKTLLN 328
Cdd:PLN02242 268 ELSERLPHLSLRMKEHCRRAMEYAKRMKELGL--KVIYPGLEDHPQHALLKSMANKgygFGGLLCLDM-DTEERANRLMR 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 551108686 329 NLKLCS----LAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVRLSVG 377
Cdd:PLN02242 345 YLQNSTqfgfMAVSLGYYETLMSCSGSSTSSELDPEEKAAAGISPGLVRMSVG 397
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
7-392 |
1.47e-83 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 261.53 E-value: 1.47e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 7 GLGTTAIHAGTLKNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSG 86
Cdd:PRK06702 6 GKGTICVQGGYTPKNGEPRVLPLYQSTTYKYDTSDDLAALFNLEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 87 MGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTS-NLDEVKKAMKENTRVVYLETPANPNLKIVD 165
Cdd:PRK06702 86 QAAIMLAVLNICSSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFNPNlTADEIVALANDKTKLVYAESLGNPAMNVLN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 166 LEGVCKVAhTNPNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVV-------TNKELADQI------ 232
Cdd:PRK06702 166 FKEFSDAA-KELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIdggnfdwTNGKYPELVepdpsy 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 233 ------------------RFVGLKDMtGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLES 294
Cdd:PRK06702 245 hgvsyvqnfgaaayivkaRVQLLRDY-GNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDS 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 295 HPGYEIAKKQMKDFGA-MISFELKGGFEAGKTLLNNLKLCSLAVSLGDTETLIQHPASMTHSPYTKEEREAAGITDGLVR 373
Cdd:PRK06702 324 NENYSLAQKYLKKGASgVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIR 403
|
410
....*....|....*....
gi 551108686 374 LSVGLENVEDIIADLEQGL 392
Cdd:PRK06702 404 LSVGIEDVSDIIADLEAAL 422
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
4-392 |
3.91e-78 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 246.26 E-value: 3.91e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 4 KKLGLGTTAIHAG-TLKNLYGTLAMPIYQTSTFIFDSAEQggrrFALEEAGYIYTRLGNPTTTVLENKIAALEeGEAG-I 81
Cdd:PRK05967 9 EKAGINTRLAHDGnDPGDYHGFVNPPVVHASTVLFPDAET----MATRGQKYTYGTRGTPTTDALCKAIDALE-GSAGtI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 82 AMSSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNL 161
Cdd:PRK05967 84 LVPSGLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGSNTF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 162 KIVDLEGVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKELADQirfvgLKDMT 241
Cdd:PRK05967 164 EMQDIPAIAEAAHRH-GAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSANEKCWPQ-----LLEAH 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 242 GAV---LGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKG 318
Cdd:PRK05967 238 GTLglcAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAA 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 551108686 319 GFEAGK----TLLNNLKLCSLAVSLGDTETLIQHpasmthsPYTKEEREAAGITDG-LVRLSVGLENVEDIIADLEQGL 392
Cdd:PRK05967 318 GPEKGKakahAFLDALEIFGLGYSWGGYESLALH-------VKLGDRTVAKAPYAGpVIRLQIGLEDVPDLKADLERGF 389
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
10-395 |
3.49e-77 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 243.25 E-value: 3.49e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 10 TTAIHAGTLKNLY-GTLAMPIYQTSTFIFDSAEQGGRRfaleEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAMSSGMG 88
Cdd:TIGR01324 1 TRLIHSGRQPRFSqGSVNPPLQRASTVLFDSHAAQRRA----KGELTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 89 AISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKIVDLEG 168
Cdd:TIGR01324 77 AVTNSILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 169 VCKVAHtNPNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKELADQIRfVGLKDMtGAVLGPQ 248
Cdd:TIGR01324 157 IAKAAR-NPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVANARTWDQLR-EHSYLM-GQMVDAD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 249 EAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGF-EAGKTLL 327
Cdd:TIGR01324 234 DAYTTLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSGLFSFVLQRLTqKQVHAFL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 551108686 328 NNLKLCSLAVSLGDTETLIqhpasMTHSPYTKEEREAAGITDG-LVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:TIGR01324 314 DHLQLFGLGYSWGGYESLA-----LCNQPELGHRPNIKRNLEGpLIRVHIGLENVDDLKADLKAGFEAI 377
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
4-394 |
1.14e-69 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 224.61 E-value: 1.14e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 4 KKLGLGTTAIHAGTLKNLY-GTLAMPIYQTSTFIFDSAEQggRRFALEEAG---YIYTRLGNPTTTVLENKIAALEEGeA 79
Cdd:PRK09028 1 MSEKKATKIVSAGRDKKWTkGVINPPVFRASTVVFDTVAE--MRHAAKNRAngeMFYGRRGTPTHFAFQAAIVELEGG-A 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 80 GIAM-SSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPAN 158
Cdd:PRK09028 78 GTALyPSGAAAISNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 159 PNLKIVDLEGVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKELADQIRFVGLk 238
Cdd:PRK09028 158 ITMEVQDVPTLSRIAHEH-DIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATANEKHWDQLREHSY- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 239 dMTGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKG 318
Cdd:PRK09028 236 -LMGQCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVLKQ 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 551108686 319 GF-EAGKTLLNNLKLCSLAVSLGDTETLIQHPASMtHSPYTKEEREAAGItdgLVRLSVGLENVEDIIADLEQGLEK 394
Cdd:PRK09028 315 GDpKAVTALVEGMQHFKMGFSWGGFESLILGVFGI-NKLRTATNWDFSKP---LIRLHIGLEDVDDLIADLEAGFER 387
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
3-395 |
1.21e-63 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 208.79 E-value: 1.21e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 3 MKKLGLGTTAIHAGTLKNLYGTLAMPIYQ-TSTFIFDSAEQGGRRFALEEAGYI-YTRLGNPTTTVLENKIAALEEGeAG 80
Cdd:PRK08114 1 MTDKKLDTQLVNAGRSKKYTQGSVNSVIQrASSLVFDSVEAKKHATRNRANGELfYGRRGTLTHFSLQEAMCELEGG-AG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 81 IAM-SSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANP 159
Cdd:PRK08114 80 CALyPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPLIGADIAKLIQPNTKVVFLESPGSI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 160 NLKIVDLEGVCK-VAHTNPNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVTNKELADQIRFVGLk 238
Cdd:PRK08114 160 TMEVHDVPAIVAaVRSVNPDAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVANARCWEQLRENSY- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 239 dMTGAVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKG 318
Cdd:PRK08114 239 -LMGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFVLKK 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 319 GF--EAGKTLLNNLKLCSLAVSLGDTETLIQhpasmthsPYTKEE----REAAGI--TDGLVRLSVGLENVEDIIADLEQ 390
Cdd:PRK08114 318 KLtdEQLANYLDNFSLFSMAYSWGGFESLIL--------ANQPEEiaaiRPAGEVdfTGTLIRLHIGLEDVDDLIADLAA 389
|
....*
gi 551108686 391 GLEKI 395
Cdd:PRK08114 390 GFARI 394
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
5-395 |
5.67e-58 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 194.17 E-value: 5.67e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 5 KLGLGTTAIHAGT-LKNLYGTLAMPIYQTSTFIFDSAEQGGRRFALEEAGYIYTRLGNPTTTVLENKIAALEEGEAGIAM 83
Cdd:PRK07050 7 KRALQTRIVQPDDqIPPGFRSFVTPVARASTVVFPDLATMRALDWRQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 84 SSGMGAISSTLWTVLKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSNLDEVKKAMKENTRVVYLETPANPNLKI 163
Cdd:PRK07050 87 PSGLAAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTMEV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 164 VDLEGVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKYLNGHGDVIAGLVVT-NKELADQIRFVGLKdmTG 242
Cdd:PRK07050 167 PDVPAITAAARAR-GVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITaDAELHAKLKLARMR--LG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 243 AVLGPQEAYYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPGLESHPGYEIAKKQMKDFGAMISFELKGGFEA 322
Cdd:PRK07050 244 IGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLFSVVFDERYSP 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 551108686 323 GK--TLLNNLKLCSLAVSLGDTETL--IQHPASMTHSPYtkeereaaGITDGLVRLSVGLENVEDIIADLEQGLEKI 395
Cdd:PRK07050 324 AQvdAFVEALELFAIGWSWGGACSLamPYDVASMRTAKW--------PHRGTLVRLYIGLEDEADLIADLEQALEAA 392
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
65-225 |
1.63e-11 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 62.40 E-value: 1.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 65 TVLENKIAALEEG--EAGIAMSSGMGAISSTLWTVLKAGDHVVTDKtlyGCTFALMNHGLTKFGVEVTFVDTSN------ 136
Cdd:cd01494 3 EELEEKLARLLQPgnDKAVFVPSGTGANEAALLALLGPGDEVIVDA---NGHGSRYWVAAELAGAKPVPVPVDDagyggl 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 137 --LDEVKKAMKENTRVVYLETPANPNLKIVDLEGVCKVAHTNpNTLVIVDNTFATPYMQKPLKL----GVDVVVHSATKY 210
Cdd:cd01494 80 dvAILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEY-GILLLVDAASAGGASPAPGVLipegGADVVTFSLHKN 158
|
170
....*....|....*
gi 551108686 211 LNGHGdviAGLVVTN 225
Cdd:cd01494 159 LGGEG---GGVVIVK 170
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
81-291 |
1.86e-06 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 49.26 E-value: 1.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 81 IAMSSG-MGAISSTLWTVLKAGDHVVTDKTlygcTFALMNHGLTKFGVEVTFVDT-------SNLDEVKKAMKENTRVVY 152
Cdd:cd00609 62 IVVTNGaQEALSLLLRALLNPGDEVLVPDP----TYPGYEAAARLAGAEVVPVPLdeeggflLDLELLEAAKTPKTKLLY 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 153 LETPANP---NLKIVDLEGVCKVAHtNPNTLVIVDNTFA--------TPYMQKPLKLGVDVVVHSATKYLNghgdvIAGL 221
Cdd:cd00609 138 LNNPNNPtgaVLSEEELEELAELAK-KHGILIISDEAYAelvydgepPPALALLDAYERVIVLRSFSKTFG-----LPGL 211
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 551108686 222 -----VVTNKELADQIRFVGLKDMTGAVLGPQEA--YYIIRGLKTFEIRMERHCKNARTIADFLNKHPKVEKVYYPG 291
Cdd:cd00609 212 rigylIAPPEELLERLKKLLPYTTSGPSTLSQAAaaAALDDGEEHLEELRERYRRRRDALLEALKELGPLVVVKPSG 288
|
|
| YnbB |
COG4100 |
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ... |
85-246 |
3.22e-06 |
|
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 443276 Cd Length: 409 Bit Score: 48.95 E-value: 3.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 85 SGMGAISSTLWTVLKAGDHV--VTDK---TLYGcTFALMNHG---LTKFGVEVTFVD-----TSNLDEVKKAMKENTRVV 151
Cdd:COG4100 83 SGTHAIALALFGVLRPGDELlsITGKpydTLEE-VIGIRGEGqgsLKEFGISYRQVPltedgKIDLEAIKKAINEKTKMV 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 152 -------YLETPAnpnLKIVDLEGVCKVAHT-NPNTLVIVDNTfatpY-----MQKPLKLGVDVVVHSATKYLNGhGdvI 218
Cdd:COG4100 162 liqrsrgYSWRPS---LTIEEIGEIIKFVKSiNPDVICFVDNC----YgefveTREPTEVGADLMAGSLIKNPGG-G--L 231
|
170 180 190
....*....|....*....|....*....|....*
gi 551108686 219 A---GLVVTNKELADQI--RFV--GLKDMTGAVLG 246
Cdd:COG4100 232 AptgGYIAGRKDLVELAayRLTapGIGKEVGATLG 266
|
|
| KBL_like |
cd06454 |
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ... |
67-272 |
1.25e-05 |
|
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.
Pssm-ID: 99747 [Multi-domain] Cd Length: 349 Bit Score: 46.79 E-value: 1.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 67 LENKIAALEEGEAGIAMSSGMGAISSTLWTVLKAGDHVVTDKtlygctfalMNH-----GLTKFGVEVTFVDTSNLDEVK 141
Cdd:cd06454 51 LEEELAEFHGKEAALVFSSGYAANDGVLSTLAGKGDLIISDS---------LNHasiidGIRLSGAKKRIFKHNDMEDLE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 142 KAMKENTRvvyletPANPNL-----------KIVDLEGVCKVAHTNpNTLVIVDNTFAT--------------PYMQKpl 196
Cdd:cd06454 122 KLLREARR------PYGKKLivtegvysmdgDIAPLPELVDLAKKY-GAILFVDEAHSVgvygphgrgveefgGLTDD-- 192
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 551108686 197 klgVDVVVHSATKYLNGHGdviaGLVVTNKELADQIRFVGLKDMTGAVLGPQEAYYIIRGL---KTFEIRMERHCKNAR 272
Cdd:cd06454 193 ---VDIIMGTLGKAFGAVG----GYIAGSKELIDYLRSYARGFIFSTSLPPAVAAAALAALevlQGGPERRERLQENVR 264
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
67-235 |
3.37e-05 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 45.37 E-value: 3.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 67 LENKIAAL--------EEGEAGIAMSSGMGAISSTLWTVLK-AGDHVVTDKTlygcTFALMNHGLTKFGVEVTFVDTS-- 135
Cdd:pfam00155 44 LREALAKFlgrspvlkLDREAAVVFGSGAGANIEALIFLLAnPGDAILVPAP----TYASYIRIARLAGGEVVRYPLYds 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 136 -----NLDEVKKAMKENTRVVYLETPANPNLKIVDLEGVCKVAHTNP--NTLVIVDNTFAT----PYMQKPLKLGVD--- 201
Cdd:pfam00155 120 ndfhlDFDALEAALKEKPKVVLHTSPHNPTGTVATLEELEKLLDLAKehNILLLVDEAYAGfvfgSPDAVATRALLAegp 199
|
170 180 190
....*....|....*....|....*....|....*.
gi 551108686 202 --VVVHSATKYLNGHGDVIaGLVVTNKELADQIRFV 235
Cdd:pfam00155 200 nlLVVGSFSKAFGLAGWRV-GYILGNAAVISQLRKL 234
|
|
| PRK06225 |
PRK06225 |
pyridoxal phosphate-dependent aminotransferase; |
88-295 |
7.02e-04 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235749 [Multi-domain] Cd Length: 380 Bit Score: 41.28 E-value: 7.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 88 GAISS---TLWTVLKAGDHVVT-DKT-LYGCTFAlmnhglTKFGVEVTFVDTSN--------LDEVKKAMKENTRVVYLE 154
Cdd:PRK06225 91 GATESlylVMRAFLSPGDNAVTpDPGyLIIDNFA------SRFGAEVIEVPIYSeecnykltPELVKENMDENTRLIYLI 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 155 TPANPnLKIV----DLEGVCKVAHTNpNTLVIVDNTFATPYMQKPLKLGVD----VVVHSATKYLNGHGDVIaGLVVTNK 226
Cdd:PRK06225 165 DPLNP-LGSSyteeEIKEFAEIARDN-DAFLLHDCTYRDFAREHTLAAEYApehtVTSYSFSKIFGMAGLRI-GAVVATP 241
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 551108686 227 ELADQIRFVGLKDMtGAVLGPQEAyyIIRGLKT---FEIRMERHC-KNARTIADFLNkhpKVEKVYYPGLESH 295
Cdd:PRK06225 242 DLIEVVKSIVINDL-GTNVIAQEA--AIAGLKVkdeWIDRIRRTTfKNQKLIKEAVD---EIEGVFLPVYPSH 308
|
|
| GDC-P |
pfam02347 |
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ... |
74-270 |
7.62e-04 |
|
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
Pssm-ID: 396772 [Multi-domain] Cd Length: 428 Bit Score: 41.59 E-value: 7.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 74 LEEGEA-GIAMSSGMGAISstlwtvlKAGDHVVTDKTLYGCTFALMNHGLTKFGVEVTFVDTSnldEVKKAMKENTRVVY 152
Cdd:pfam02347 133 LDEGTAaAEAMALAARASK-------KKGKKFVVDKDVHPQTLEVLKTRAKPFGIEIVEVDYT---EEGVTDLKDVFGVL 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 153 LETPANPNlKIVDLEGVCKVAHTNPNTLVIVDNTFATPYMQKPLKLGVDVVVHSATKY--LNGHGDVIAGLVVTNKELAD 230
Cdd:pfam02347 203 VQYPNTDG-RIEDYKELIELAHQRKSLVVVAADLLALTLLKPPGEFGADIAVGSAQRFgvPLGYGGPHAGFFAVKKELVR 281
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 551108686 231 QI--RFVGL-KDMTGavlgpQEAYYIIrgLKTFE--IRMERHCKN 270
Cdd:pfam02347 282 KMpgRLVGVsKDANG-----KRALRLA--LQTREqhIRRDKATSN 319
|
|
| AGAT_like |
cd06451 |
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ... |
65-212 |
1.67e-03 |
|
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.
Pssm-ID: 99744 [Multi-domain] Cd Length: 356 Bit Score: 40.35 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 65 TVLEN--KIAALEEGEAGIAMSSGMGAISSTLWTVLKAGDHVVTDKT-LYGCTFALMnhgLTKFGVEVTFVDTS-----N 136
Cdd:cd06451 36 EILEGlrYVFQTENGLTFLLSGSGTGAMEAALSNLLEPGDKVLVGVNgVFGDRWADM---AERYGADVDVVEKPwgeavS 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 137 LDEVKKAMKENT----RVVYLETP---ANPnlkivdLEGVCKVAHtNPNTLVIVDNTF---ATP-YMQkplKLGVDVVVH 205
Cdd:cd06451 113 PEEIAEALEQHDikavTLTHNETStgvLNP------LEGIGALAK-KHDALLIVDAVSslgGEPfRMD---EWGVDVAYT 182
|
....*..
gi 551108686 206 SATKYLN 212
Cdd:cd06451 183 GSQKALG 189
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
104-266 |
4.37e-03 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 39.14 E-value: 4.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 104 VVTDKTLYGCTFALMNHGLTKFGVEVTFVD-----TSNLDEVKKAMKENTRVVYLEtpaNPN-LKIV--DLEGVCKVAHT 175
Cdd:cd00613 111 VLVPDSAHPTNPAVARTRGEPLGIEVVEVPsdeggTVDLEALKEEVSEEVAALMVQ---YPNtLGVFedLIKEIADIAHS 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 176 NpNTLVIVD-NTFATPYMQKPLKLGVDVVVHSATKYLNGH--GDVIAGLVVTNKELADQI--RFVG-LKDMTGavlgpQE 249
Cdd:cd00613 188 A-GALVYVDgDNLNLTGLKPPGEYGADIVVGNLQKTGVPHggGGPGAGFFAVKKELVRFLpgRLVGvTKDAEG-----NR 261
|
170
....*....|....*....
gi 551108686 250 AYYIIrgLKTFE--IRMER 266
Cdd:cd00613 262 AFRLA--LQTREqhIRREK 278
|
|
| PRK06836 |
PRK06836 |
pyridoxal phosphate-dependent aminotransferase; |
81-159 |
4.71e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180720 Cd Length: 394 Bit Score: 39.02 E-value: 4.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551108686 81 IAMSSGM-GAISSTLWTVLKAGDHVVTdktL------YGctFALMNHGLTKfgVEV-----TFvdTSNLDEVKKAMKENT 148
Cdd:PRK06836 99 IVMTCGAaGALNVALKAILNPGDEVIV---FapyfveYR--FYVDNHGGKL--VVVptdtdTF--QPDLDALEAAITPKT 169
|
90
....*....|.
gi 551108686 149 RVVYLETPANP 159
Cdd:PRK06836 170 KAVIINSPNNP 180
|
|
| |
