|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07111 |
PRK07111 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
32-790 |
0e+00 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 235937 [Multi-domain] Cd Length: 735 Bit Score: 1309.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 32 IRKRDGRVIGFDSTKIVEAVRKAFVACGIDAPELLASEVALEVLSRLSEMGEDTPDVEAIQDLVEKALMDQGHDDVAKAY 111
Cdd:PRK07111 5 IVKRDGREVPFDEEKITNAIFKAAEAVGGELDESEAIELTQKVIKYLEEKYKEEVTVEDIQDLVEKVLIENGHAETAKAY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 112 ILYRQRRTVARDQQSALMRTLREITfasaeeADAKRENANVDGNSAMGSMLRYGTESAKQFNLLEVLDPTHAAAHRDGDI 191
Cdd:PRK07111 85 ILYRAERTRIREIKSDLMKAIEEIG------NDTDRENANVSGNTPSGKMLRIASESNKDYYNLYLLPKELAKAHENGDI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 192 HIHDLDFLTLTTTCCQINLTDLFEHGFSTGHGVLRAPQSIGSYAALACIAIQSNQNDQHGGQAVPNFDRDMAPGVAKTFV 271
Cdd:PRK07111 159 HIHDLDFYNLTTTCLQIDLKKLLERGFNTGHGYIREPKRIESAAALACIILQSNQNDMHGGQSIPNFDNDMAPFVEKTFR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 272 KAAQTGLTRTFEVLGGDEEYLDEvreaasgwvlepdgaALAHEKEQVAKLFAGLIDDTDRVADRVRRQAVEETRRQTYQA 351
Cdd:PRK07111 239 RHRKEILEKLLELGVGEEVDEKE---------------SLNEEEELLLLLLALDFNIAKKAQEKADELAEKETRKRTYQA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 352 MEALIANLNTMNSRAGAQTPFSSINYGTDTSPEARMVMHCLLEATEAGLGGGETAIFPIQIFRVQKGVNLDDDDPNHDLF 431
Cdd:PRK07111 304 MEGFIHNLNTMHSRAGAQVPFSSINYGTDTSPEGRMVCENLLLATEKGLGKGETPIFPIQIFRVKEGVNYNEEDPNYDLF 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 432 RLACRVSAKRLFPNFSFQDAPFNAEYYVPGHPETEIAYMGCRTRVMSNVHDPsrAQTWGRGNLSFTSINLPRLAIEANHD 511
Cdd:PRK07111 384 KLACRVAAKRLFPNFSFLDAPFNKEYYDKGRPPTEVATMGCRTRVMSNVNGE--EGTKGRGNLSFTTINLPRLAIEAKKD 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 512 VNAFFTSFDRMIDLVIDQLLDRLKIQSHKLVRNFPFLMGQGVWIGSENLGPDDAVAEVLEHGTLSVGFIGLAETLTALVG 591
Cdd:PRK07111 462 IDKFFELLDERLELAIEQLLHRYEVQKTLKVKDFPFLMGQGLWKGSENLGPDDSIEPVLKQGTLGIGFIGLAETLVALTG 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 592 VHHGESEEAQQLGLRIVGHLRERMDEAAERTGLNFSALATPAEGLSGRFVRMDRQRYGSIPGVTDREYYTNSFHVPVWYH 671
Cdd:PRK07111 542 KHHGESEEAQELGLKIVSHMRDFCDEYKEEYKLNYSLLATPAEGLSGRFIKMDRKKFGEIKGVTDKEYYTNSFHVPVYYP 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 672 IGAADKIRIEAPYHAFTNGGHISYVELSGDPARNVDAFETLVRYMAASGIGYGSINHPVDRDPQCGYTGIIDDECPKCGR 751
Cdd:PRK07111 622 ISIFEKIEIEAPYHKLTNGGHISYVELDGDPSKNVEAFEIIVKAMKNTNIGYGSINHPVDRCPVCGYLGVIEDKCPKCGS 701
|
730 740 750
....*....|....*....|....*....|....*....
gi 550741585 752 HEdsgsFDRIRRITGYLvGGLDRFNDAKRAEVRDRVKHG 790
Cdd:PRK07111 702 TN----IQRIRRITGYL-GTLDRFNSAKKAERRDRVKHG 735
|
|
| NrdD |
COG1328 |
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; ... |
32-779 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Anaerobic ribonucleoside-triphosphate reductase is part of the Pathway/BioSystem: Thymidylate biosynthesis
Pssm-ID: 440939 [Multi-domain] Cd Length: 671 Bit Score: 892.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 32 IRKRDGRVIGFDSTKIVEAVRKAFVACGI-DAPELLASEVALEVLSRLSEMGE-DTPDVEAIQDLVEKALMDQGHDDVAK 109
Cdd:COG1328 5 VIKRDGRVVPFDPEKIANAIKKAAKAVGGeDRDEELAEEIADEVEKELERLGGgGTITVEEIQDIVEKVLMESGHPEVAK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 110 AYILYRQRRTVARDQQSALMRTLREITFASAEEadaKRENANVdGNSAMGSMLRYGTESAKQFNLLEVLDPTHAAAHRDG 189
Cdd:COG1328 85 AYILYREQRTRLREARTTLVDDIELLDEYDDWR---VNENANK-SYSFSTQRDLIAGEVSKEYALNKILPPEVADAHRNG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 190 DIHIHDLDFLTLTTTCCQINLTDLFEHGFSTGHGVLRAPQSIGSYAALACIAIQSNQNDQHGGQAVPNFDRDMAPGVAKt 269
Cdd:COG1328 161 DIHIHDLDYLPRMTNCCLWDLRDLLKNGFNGGNGKVEPPKHIQTALAQMAQIIATVQSEQAGGQAFSRFDTYLAPYVRK- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 270 fvkaaqtgltrtfevlggdeeyldevreaasgwvlepdgaalahekeqvaklfagliddtdrvadrvrRQAVEETRRQTY 349
Cdd:COG1328 240 --------------------------------------------------------------------DKLEGKTYKEIK 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 350 QAMEALIANLNTMNSRAGaQTPFSSINYGTDT----SPEARMVMHCLLEATEAGLGGGETAIFPIQIFRVQKGVNLDDDD 425
Cdd:COG1328 252 QAMQSLEYNLNTLPSRRG-QTPFTSITFGLGTpedfSWEMRMINKAILEVRIEGDGEGRTFIFPKLIFNITEGFNWEPED 330
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 426 PNHDLFRLACRVSAKRLFPNFSFQDAPFNaeYYVPghpeTEIAYMGCRTRVMSNVHDPsrAQTWGRGNLSFTSINLPRLA 505
Cdd:COG1328 331 PNYDLLQLAFECTAKRGYPYFLNYDNSDE--LYKG----SFKRSMGCRLFLDGWENGE--ELNRGRGNLGVVTLNLPRIA 402
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 506 IEANHDVNAFFTSFDRMIDLVIDQLLDRLK-IQSHKLVRNFPFLMGQGVWIGseNLGPDDAVAEVLEHGTLSVGFIGLAE 584
Cdd:COG1328 403 YEAKGDEEKFFEILDERLDLAKEALEIKRKrLQKLAKAGLAPILYQTGAYLG--RLKPDDSIDELFKNGFSTIGYIGLNE 480
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 585 TLTALVGVHHGESEEAQQLGLRIVGHLRERMDEAAERTGLNFSALATPAEGLSGRFVRMDRQRYGSIPGVTDREYYTNSF 664
Cdd:COG1328 481 MLLNFTGKHHIESEEAKAFALEILKHMRERADEWQEETGYLYSLYATPAESLTYRFAKLDKKRFGDIIGVTDKPYYTNSF 560
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 665 HVPVWYHIGAADKIRIEAPYHAFTNGGHISYVELsGDPARNVDAFETLVRY-MAASGIGYGSINHPVDRDPQCGYTGIID 743
Cdd:COG1328 561 HLPVRKTIDPFEKLDFEDEYQPLYTGGTISYVEL-GELQPNPEALEAVVRYaYDNYRIGYLGINPPFDICPKCGYLGGEH 639
|
730 740 750
....*....|....*....|....*....|....*.
gi 550741585 744 DECPKCGRHEDsgsFDRIRRITGYLvGGLDRFNDAK 779
Cdd:COG1328 640 DECPKCGNEDT---VEVIRRTCGYL-GNVQPWNDGK 671
|
|
| NRDD |
pfam13597 |
Anaerobic ribonucleoside-triphosphate reductase; |
149-789 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase;
Pssm-ID: 463930 [Multi-domain] Cd Length: 554 Bit Score: 770.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 149 NANVDGNSAMGSMLRYGTESAKQFNLLEVLDPTHAAAHRDGDIHIHDLDFL-TLTTTCCQINLTDLFEHGFSTGHGVLRA 227
Cdd:pfam13597 1 NANKDSYSPSGQRLYIAGEVSKDYALRKLLPPEIADAHEEGDIHIHDLDYYaLRTPYCCGIDLRDLLENGFVTGNGVSRP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 228 PQSIGSYAALACIAIQSNQNDQHGGQAVPNFDRDMAPGVAKTFVKAAQtgltrtfevlggdeeyldevreaasgwvlepd 307
Cdd:pfam13597 81 PKHIETACAQAVNILATVQNEQAGGQAFSSFDTYLAPFVRKDYEKHLK-------------------------------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 308 gaalahekeqvaklfagliddtdrvadrvrrqavEETRRQTYQAMEALIANLNTMNSRAGAQTPFSSINYGTDTSPEARM 387
Cdd:pfam13597 129 ----------------------------------GLTYKEVKQAMQAFVYNLNTMPSRRGGQTPFTNINLGLDTPKEGRD 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 388 VMHC----LLEATEAGLGGGETAI-FPIQIFRVQKGVNLDDDDPNHDLFRLACRVSAKRLFPNFSFQDapfnaeYYVPGH 462
Cdd:pfam13597 175 EMDMiikaLLEVMLEGDGNGGTPFtFPIPIYKLKEGFNWDEGDPNYDLFELAFECTAKRGYPYFSNFD------SDLLPG 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 463 PETeIAYMGCRTRVM--SNVHDPSRAqtwgRGNLSFTSINLPRLAIEANHDVNAFFTSFDRMIDLVIDQLLDRLKIQSHK 540
Cdd:pfam13597 249 DGY-VASMGCRLRLDlrPNRKRFGGL----RGNIGVVTINLPRIAYEAAGDEDKFFELLDERLELAKEALLIRREVLKKL 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 541 LVRN-FPFLMGQGVWIGSENlgpddavaevlehgTLSVGFIGLAETLTALVGVHHGESEEAQQLGLRIVGHLRERMDEAA 619
Cdd:pfam13597 324 LAKGlLPFLMGEGYLRGGNH--------------TLTIGFIGLNEALKALTGKHHGESEEAKEFALKILKHMREKADEWK 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 620 ERTGLNFSALATPAEGLSGRFVRMDRQRYGSIPGVTDREYYTNSFHVPVWYHIGAADKIRIEAPYHAFTNGGHISYVELs 699
Cdd:pfam13597 390 EETGLNFSLEATPAESLSYRFAKLDKKRFGEIKGVTDKPYYTNSFHVPVDYTIDAFEKLKLEAPFQPLTTGGHISHVEL- 468
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 700 GDPARNVDAFETLVRYMAASGIGYGSINHPVDRDPQCGYTGIIdDECPKCGRHEDsgSFDRIRRITGYLvGGLDRFNDAK 779
Cdd:pfam13597 469 GEAQPNPEALEKLVRIAYDTGIGYFSINPPIDVCPDCGYTGEI-EECPNCGNHDE--KVEVIRRITGYL-RPVSDWNKGK 544
|
650
....*....|
gi 550741585 780 RAEVRDRVKH 789
Cdd:pfam13597 545 QAELKDRVKH 554
|
|
| NrdD |
TIGR02487 |
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive ... |
147-789 |
0e+00 |
|
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme (TIGR02491). Together the two form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274159 [Multi-domain] Cd Length: 579 Bit Score: 668.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 147 RENANVDGNSAMGSMLRYGTESAKQFNLLEVLDPTHAAAHRDGDIHIHDLDF-LTLTTTCCQINLTDLFEHGFSTGHGVL 225
Cdd:TIGR02487 1 NENANMDSPTPSTQRKLIASEVSKDYALLHLLPKDIARAHLNGDIHIHDLDYaLTLTTNCCLHDLRNLLKYGFRTGNIVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 226 RAPQSIGSYAALACIAIQSNQNDQHGGQAVPNFDRDMAPGVAKTFVKaaqtgltrtfevlggdeeyldevreaasgwvle 305
Cdd:TIGR02487 81 KPPKHIDVALNHIVNILQSLQNEQYGGQSFPEFDTLLAPYIEKTNLK--------------------------------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 306 pdgaalahEKEQVAKLFaGLIDDTDRVAdrvrrqaVEETRRQTYQAMEALIANLNTMNSRAGaQTPFSSINYGTDTSPEA 385
Cdd:TIGR02487 128 --------HRKVLQQLQ-LLLFEATEYA-------ARRTFTDVTQAMQGPEYNPNTLHSAGG-QTPFESIGYGTETSKEG 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 386 RMVMHCLLEATEAGLGGGETAIFPIQIFRVQKGVNLDDDDPnHDLFRLACRVSAKRLFPNFSFQDAPFNAEYYVPghpet 465
Cdd:TIGR02487 191 RMIAKALLDVRMEGDGKGEPFIFPKIIFKVREGFNWDEPDP-YDLFELAFECAAKRGYPYFLNLDPEDNVKEDVR----- 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 466 eiAYMGCRTRVMSNVHDPSRAQTWGRGNLSFTSINLPRLAIEANHDVNAFFTSFDRMIDLVIDQLLDRLKIQSHKLVRNF 545
Cdd:TIGR02487 265 --YPMGCRTFLSPNENGDGEESYIGRGNIGVTSINLPRIAYKSRGDEEEFFEELDEYLEIAKEALEIRREYLKKMLAKDL 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 546 PFLMGQGVWIGSENLgpDDAVAEVLEHGTLSVGFIGLAETLTALVGVHHGESEEAQQLGLRIVGHLRERMDEAAERTGLN 625
Cdd:TIGR02487 343 PPMYSQGGWDGGNLL--DESVEEILKSGTNSIGFIGLNEALVALTGKHLHEEEEARELAIRILEFIRDKADEFKKETGLN 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 626 FSALATPAEGLSGRFVRMDRQRYGSIPGVTDREYYTNSFHVPVWYHIGAADKIRIEAPYHAFTNGGHISYVELSGDpARN 705
Cdd:TIGR02487 421 YSVYATPAESLCGRFAKKDREEFGEIPGVTDKPYYTNSFHVPVYEDVNLGEKIDIEAPFHPLTNGGHITYIELDEA-IPD 499
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 706 VDAFETLVRYMAASGIGYGSINHPVDRDPQCGYTGIID-DECPKCGRHEdsgsFDRIRRITGYLvGGLDRFNDAKRAEVR 784
Cdd:TIGR02487 500 PEALKDITKKAMKNGIGYFGINPPVDVCEDCGYTGEGLnDKCPKCGSHD----IEVISRITGYL-GPVENWNDGKQAEFK 574
|
....*
gi 550741585 785 DRVKH 789
Cdd:TIGR02487 575 DRKKH 579
|
|
| RNR_III |
cd01675 |
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
148-770 |
0e+00 |
|
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.
Pssm-ID: 153084 [Multi-domain] Cd Length: 555 Bit Score: 649.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 148 ENANVDgNSAMGSMLRYGTESAKQFNLLEVLDPTHAAAHRDGDIHIHDLDFLTLTTTCCQINLTDLFEHGFSTGHGVLRA 227
Cdd:cd01675 1 ENANVD-SSPGSTMKDLAAGIVKKYYLLKILPKEIARAHLNGDIHIHDLDYLPLTPYCCGWDLRPLLEKGFTTGNGIIEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 228 PQSIGSYAALACIAIQSNQNDQHGGQAVPNFDRDMAPGVAKTFVKAAQTGltrtfevlggdeeyldevreaasgwvlepd 307
Cdd:cd01675 80 PKHLSSALGHIVNFLGTVQNEQAGGQAFPEFDTYLAPFVRKDYLKYRLTA------------------------------ 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 308 gaalahekeqvaklfagliddtdrvadrvrrqaveeTRRQTYQAMEALIANLNTMnSRAGAQTPFSSINYG--------- 378
Cdd:cd01675 130 ------------------------------------TRKEIKQAMQGFIYNLNTL-SRRGGQTPFTNITLGlvcpkdlef 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 379 ----------TDTSPEARMVMHCLLEATEAGLGGGETAIFPIQIFRVQKGVNLDdddPNHDLFRLACRVSAKRLFPNFSF 448
Cdd:cd01675 173 egggepvftyGDTDKEARMIQKAFLEVRLEGDAKGRPFTFPIPTFNVTEGFNLD---PNYDLKELAFECAAKRGYPYFLN 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 449 QDAPFNAEYYVpghpeteiAYMGCRTRVMSNVHDPS---RAQTWGRGNLSFTSINLPRLAIEANHDVNAFFTSFDRMIDL 525
Cdd:cd01675 250 FDNSDNVPGDV--------RAMGCRLFLDKNELKRGgglEGSGDGTGNIGVVTINLPRIAYEARGDEEKFFELLDEYLEL 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 526 VIDQLLDRLKIQSHKLVRNFPFLMGQGVWIGSEnlgpddavAEVLEHGTLSVGFIGLAETLTALVGVHHGESEEAQQLGL 605
Cdd:cd01675 322 AKDALEIRRKRLKEALARGLPPLYQEGLGGGKL--------LFILKRHTLTIGFIGLNEAAEALTGKGIGESEEAREFGI 393
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 606 RIVGHLRERMDEAAERTGLNFSALATPAEGLSGRFVRMDRQRYGS-IPGVTDREYYTNSFHVPVWYHIGAADKIRIEAPY 684
Cdd:cd01675 394 RILEHIRERADEFKEETGLLYSVEATPAESLAYRFAKKDRKKYGDiIPGVTDKPYYTNSFHVPVYEDIDPFEKIDIEAKL 473
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 685 HAFTNGGHISYVELsGDPARNVDAFETLVRYMAASGIGYGSINHPVDRDPQCGYTG-IIDDECPKCGRHEdsgsFDRIRR 763
Cdd:cd01675 474 HPLTTGGHILHIEL-GEAKPNPEALEALVKKAAKRGVIYFGINTPIDICNDCGYIGeGEGFKCPKCGSED----VEVISR 548
|
....*..
gi 550741585 764 ITGYLVG 770
Cdd:cd01675 549 ITGYLGP 555
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07111 |
PRK07111 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
32-790 |
0e+00 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 235937 [Multi-domain] Cd Length: 735 Bit Score: 1309.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 32 IRKRDGRVIGFDSTKIVEAVRKAFVACGIDAPELLASEVALEVLSRLSEMGEDTPDVEAIQDLVEKALMDQGHDDVAKAY 111
Cdd:PRK07111 5 IVKRDGREVPFDEEKITNAIFKAAEAVGGELDESEAIELTQKVIKYLEEKYKEEVTVEDIQDLVEKVLIENGHAETAKAY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 112 ILYRQRRTVARDQQSALMRTLREITfasaeeADAKRENANVDGNSAMGSMLRYGTESAKQFNLLEVLDPTHAAAHRDGDI 191
Cdd:PRK07111 85 ILYRAERTRIREIKSDLMKAIEEIG------NDTDRENANVSGNTPSGKMLRIASESNKDYYNLYLLPKELAKAHENGDI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 192 HIHDLDFLTLTTTCCQINLTDLFEHGFSTGHGVLRAPQSIGSYAALACIAIQSNQNDQHGGQAVPNFDRDMAPGVAKTFV 271
Cdd:PRK07111 159 HIHDLDFYNLTTTCLQIDLKKLLERGFNTGHGYIREPKRIESAAALACIILQSNQNDMHGGQSIPNFDNDMAPFVEKTFR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 272 KAAQTGLTRTFEVLGGDEEYLDEvreaasgwvlepdgaALAHEKEQVAKLFAGLIDDTDRVADRVRRQAVEETRRQTYQA 351
Cdd:PRK07111 239 RHRKEILEKLLELGVGEEVDEKE---------------SLNEEEELLLLLLALDFNIAKKAQEKADELAEKETRKRTYQA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 352 MEALIANLNTMNSRAGAQTPFSSINYGTDTSPEARMVMHCLLEATEAGLGGGETAIFPIQIFRVQKGVNLDDDDPNHDLF 431
Cdd:PRK07111 304 MEGFIHNLNTMHSRAGAQVPFSSINYGTDTSPEGRMVCENLLLATEKGLGKGETPIFPIQIFRVKEGVNYNEEDPNYDLF 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 432 RLACRVSAKRLFPNFSFQDAPFNAEYYVPGHPETEIAYMGCRTRVMSNVHDPsrAQTWGRGNLSFTSINLPRLAIEANHD 511
Cdd:PRK07111 384 KLACRVAAKRLFPNFSFLDAPFNKEYYDKGRPPTEVATMGCRTRVMSNVNGE--EGTKGRGNLSFTTINLPRLAIEAKKD 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 512 VNAFFTSFDRMIDLVIDQLLDRLKIQSHKLVRNFPFLMGQGVWIGSENLGPDDAVAEVLEHGTLSVGFIGLAETLTALVG 591
Cdd:PRK07111 462 IDKFFELLDERLELAIEQLLHRYEVQKTLKVKDFPFLMGQGLWKGSENLGPDDSIEPVLKQGTLGIGFIGLAETLVALTG 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 592 VHHGESEEAQQLGLRIVGHLRERMDEAAERTGLNFSALATPAEGLSGRFVRMDRQRYGSIPGVTDREYYTNSFHVPVWYH 671
Cdd:PRK07111 542 KHHGESEEAQELGLKIVSHMRDFCDEYKEEYKLNYSLLATPAEGLSGRFIKMDRKKFGEIKGVTDKEYYTNSFHVPVYYP 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 672 IGAADKIRIEAPYHAFTNGGHISYVELSGDPARNVDAFETLVRYMAASGIGYGSINHPVDRDPQCGYTGIIDDECPKCGR 751
Cdd:PRK07111 622 ISIFEKIEIEAPYHKLTNGGHISYVELDGDPSKNVEAFEIIVKAMKNTNIGYGSINHPVDRCPVCGYLGVIEDKCPKCGS 701
|
730 740 750
....*....|....*....|....*....|....*....
gi 550741585 752 HEdsgsFDRIRRITGYLvGGLDRFNDAKRAEVRDRVKHG 790
Cdd:PRK07111 702 TN----IQRIRRITGYL-GTLDRFNSAKKAERRDRVKHG 735
|
|
| NrdD |
COG1328 |
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; ... |
32-779 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Anaerobic ribonucleoside-triphosphate reductase is part of the Pathway/BioSystem: Thymidylate biosynthesis
Pssm-ID: 440939 [Multi-domain] Cd Length: 671 Bit Score: 892.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 32 IRKRDGRVIGFDSTKIVEAVRKAFVACGI-DAPELLASEVALEVLSRLSEMGE-DTPDVEAIQDLVEKALMDQGHDDVAK 109
Cdd:COG1328 5 VIKRDGRVVPFDPEKIANAIKKAAKAVGGeDRDEELAEEIADEVEKELERLGGgGTITVEEIQDIVEKVLMESGHPEVAK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 110 AYILYRQRRTVARDQQSALMRTLREITFASAEEadaKRENANVdGNSAMGSMLRYGTESAKQFNLLEVLDPTHAAAHRDG 189
Cdd:COG1328 85 AYILYREQRTRLREARTTLVDDIELLDEYDDWR---VNENANK-SYSFSTQRDLIAGEVSKEYALNKILPPEVADAHRNG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 190 DIHIHDLDFLTLTTTCCQINLTDLFEHGFSTGHGVLRAPQSIGSYAALACIAIQSNQNDQHGGQAVPNFDRDMAPGVAKt 269
Cdd:COG1328 161 DIHIHDLDYLPRMTNCCLWDLRDLLKNGFNGGNGKVEPPKHIQTALAQMAQIIATVQSEQAGGQAFSRFDTYLAPYVRK- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 270 fvkaaqtgltrtfevlggdeeyldevreaasgwvlepdgaalahekeqvaklfagliddtdrvadrvrRQAVEETRRQTY 349
Cdd:COG1328 240 --------------------------------------------------------------------DKLEGKTYKEIK 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 350 QAMEALIANLNTMNSRAGaQTPFSSINYGTDT----SPEARMVMHCLLEATEAGLGGGETAIFPIQIFRVQKGVNLDDDD 425
Cdd:COG1328 252 QAMQSLEYNLNTLPSRRG-QTPFTSITFGLGTpedfSWEMRMINKAILEVRIEGDGEGRTFIFPKLIFNITEGFNWEPED 330
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 426 PNHDLFRLACRVSAKRLFPNFSFQDAPFNaeYYVPghpeTEIAYMGCRTRVMSNVHDPsrAQTWGRGNLSFTSINLPRLA 505
Cdd:COG1328 331 PNYDLLQLAFECTAKRGYPYFLNYDNSDE--LYKG----SFKRSMGCRLFLDGWENGE--ELNRGRGNLGVVTLNLPRIA 402
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 506 IEANHDVNAFFTSFDRMIDLVIDQLLDRLK-IQSHKLVRNFPFLMGQGVWIGseNLGPDDAVAEVLEHGTLSVGFIGLAE 584
Cdd:COG1328 403 YEAKGDEEKFFEILDERLDLAKEALEIKRKrLQKLAKAGLAPILYQTGAYLG--RLKPDDSIDELFKNGFSTIGYIGLNE 480
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 585 TLTALVGVHHGESEEAQQLGLRIVGHLRERMDEAAERTGLNFSALATPAEGLSGRFVRMDRQRYGSIPGVTDREYYTNSF 664
Cdd:COG1328 481 MLLNFTGKHHIESEEAKAFALEILKHMRERADEWQEETGYLYSLYATPAESLTYRFAKLDKKRFGDIIGVTDKPYYTNSF 560
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 665 HVPVWYHIGAADKIRIEAPYHAFTNGGHISYVELsGDPARNVDAFETLVRY-MAASGIGYGSINHPVDRDPQCGYTGIID 743
Cdd:COG1328 561 HLPVRKTIDPFEKLDFEDEYQPLYTGGTISYVEL-GELQPNPEALEAVVRYaYDNYRIGYLGINPPFDICPKCGYLGGEH 639
|
730 740 750
....*....|....*....|....*....|....*.
gi 550741585 744 DECPKCGRHEDsgsFDRIRRITGYLvGGLDRFNDAK 779
Cdd:COG1328 640 DECPKCGNEDT---VEVIRRTCGYL-GNVQPWNDGK 671
|
|
| PRK14704 |
PRK14704 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
128-789 |
0e+00 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 184798 [Multi-domain] Cd Length: 618 Bit Score: 815.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 128 LMRTLREITfaSAEEADAKRENANVDGNSAMGSMLRYGTESAKQFNLLEVLDPTHAAAHRDGDIHIHDLDF-LTLTTTCC 206
Cdd:PRK14704 11 LMRVFETIV--HGNEQDLMQENANVDGRSPMGVMGTFASESAKYYAVENLLSDQVKKAINENILYPHDLDFyATGTTTCS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 207 QINLTDLFEHGFSTGHGVLRAPQSIGSYAALACIAIQSNQNDQHGGQAVPNFDRDMAPGVAKTFvkaaqtgltrtfevlg 286
Cdd:PRK14704 89 QIPLAQMLANGFHTGHGHMRQPQDIKSALALSSIIFQANQNMQHGGQSFALFDVDLAPYVRKTV---------------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 287 gdEEYLDEVREaasgWVLEpdgaalahekeqvaklfagliddtdrvADRVRRQAVEETRRQTYQAMEALIANLNTMNSRA 366
Cdd:PRK14704 153 --ERHKKRLQS----YPLT---------------------------KEQIEEFAWKETENDTYQACEAFIHNSNSMHSRG 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 367 GAQTPFSSINYGTDTSPEARMVMHCLLEATEAGLGGGETAIFPIQIFRVQKGVNLDDDDPNHDLFRLACRVSAKRLFPNF 446
Cdd:PRK14704 200 GGQVPFISINYGTDTSKEGRLLIKQLLKATQAGLGKGETPIFPIQIFKMKKGVNFEESDPNYDLFELALETTAERLFPNF 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 447 SFQDAPFNAEYYvPGHPETEIAYMGCRTRVMSNVHdpSRAQTWGRGNLSFTSINLPRLAIeANHDVNAFFTSFDRMIDLV 526
Cdd:PRK14704 280 SFLDAPFNAVHY-DGRPESEVCYMGCRTRVMSNIH--GEETAIGRGNLSFTSINLVKLAL-ISGSKEAFFEALNYYLDLG 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 527 IDQLLDRLKIQSHKLVRNFPFLMGQGVWIGSENLGPDDAVAEVLEHGTLSVGFIGLAETLTALVGVHHGESEEAQQLGLR 606
Cdd:PRK14704 356 IKQLLERFEYQCTKRARDFRFLYSQGVWRGGEKLQPEDSVASILKQGTLSLGFIGLAECLVALTGKHHGEDEESWKLGYE 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 607 IVGHLRERMDEAAERTGLNFSALATPAEGLSGRFVRMDRQRYGSIPGVTDREYYTNSFHVPVWYHIGAADKIRIEAPYHA 686
Cdd:PRK14704 436 IISFMRDRMDKATEEHELNFSVIATPAEGLSGKFVKKDREEFGVISGITNHNYYTNSFHIPVYYNIQAINKIRLEGPFHA 515
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 687 FTNGGHISYVELSGDPARNVDAFETLVRYMAASGIGYGSINHPVDRDPQCGYTGIIDDECPKCGrHEDSGSFDRIRRITG 766
Cdd:PRK14704 516 LCNGGHITYIELDGAAMHNKKALKQIVQAMAEHGVGYGSINHPVDRCKCCSYHGVIGNECPSCG-NEDEANIERIRRITG 594
|
650 660
....*....|....*....|...
gi 550741585 767 YLVGGLDRFNDAKRAEVRDRVKH 789
Cdd:PRK14704 595 YLVGDMSKWNSAKRSEEMDRVKH 617
|
|
| NRDD |
pfam13597 |
Anaerobic ribonucleoside-triphosphate reductase; |
149-789 |
0e+00 |
|
Anaerobic ribonucleoside-triphosphate reductase;
Pssm-ID: 463930 [Multi-domain] Cd Length: 554 Bit Score: 770.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 149 NANVDGNSAMGSMLRYGTESAKQFNLLEVLDPTHAAAHRDGDIHIHDLDFL-TLTTTCCQINLTDLFEHGFSTGHGVLRA 227
Cdd:pfam13597 1 NANKDSYSPSGQRLYIAGEVSKDYALRKLLPPEIADAHEEGDIHIHDLDYYaLRTPYCCGIDLRDLLENGFVTGNGVSRP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 228 PQSIGSYAALACIAIQSNQNDQHGGQAVPNFDRDMAPGVAKTFVKAAQtgltrtfevlggdeeyldevreaasgwvlepd 307
Cdd:pfam13597 81 PKHIETACAQAVNILATVQNEQAGGQAFSSFDTYLAPFVRKDYEKHLK-------------------------------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 308 gaalahekeqvaklfagliddtdrvadrvrrqavEETRRQTYQAMEALIANLNTMNSRAGAQTPFSSINYGTDTSPEARM 387
Cdd:pfam13597 129 ----------------------------------GLTYKEVKQAMQAFVYNLNTMPSRRGGQTPFTNINLGLDTPKEGRD 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 388 VMHC----LLEATEAGLGGGETAI-FPIQIFRVQKGVNLDDDDPNHDLFRLACRVSAKRLFPNFSFQDapfnaeYYVPGH 462
Cdd:pfam13597 175 EMDMiikaLLEVMLEGDGNGGTPFtFPIPIYKLKEGFNWDEGDPNYDLFELAFECTAKRGYPYFSNFD------SDLLPG 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 463 PETeIAYMGCRTRVM--SNVHDPSRAqtwgRGNLSFTSINLPRLAIEANHDVNAFFTSFDRMIDLVIDQLLDRLKIQSHK 540
Cdd:pfam13597 249 DGY-VASMGCRLRLDlrPNRKRFGGL----RGNIGVVTINLPRIAYEAAGDEDKFFELLDERLELAKEALLIRREVLKKL 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 541 LVRN-FPFLMGQGVWIGSENlgpddavaevlehgTLSVGFIGLAETLTALVGVHHGESEEAQQLGLRIVGHLRERMDEAA 619
Cdd:pfam13597 324 LAKGlLPFLMGEGYLRGGNH--------------TLTIGFIGLNEALKALTGKHHGESEEAKEFALKILKHMREKADEWK 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 620 ERTGLNFSALATPAEGLSGRFVRMDRQRYGSIPGVTDREYYTNSFHVPVWYHIGAADKIRIEAPYHAFTNGGHISYVELs 699
Cdd:pfam13597 390 EETGLNFSLEATPAESLSYRFAKLDKKRFGEIKGVTDKPYYTNSFHVPVDYTIDAFEKLKLEAPFQPLTTGGHISHVEL- 468
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 700 GDPARNVDAFETLVRYMAASGIGYGSINHPVDRDPQCGYTGIIdDECPKCGRHEDsgSFDRIRRITGYLvGGLDRFNDAK 779
Cdd:pfam13597 469 GEAQPNPEALEKLVRIAYDTGIGYFSINPPIDVCPDCGYTGEI-EECPNCGNHDE--KVEVIRRITGYL-RPVSDWNKGK 544
|
650
....*....|
gi 550741585 780 RAEVRDRVKH 789
Cdd:pfam13597 545 QAELKDRVKH 554
|
|
| NrdD |
TIGR02487 |
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive ... |
147-789 |
0e+00 |
|
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme (TIGR02491). Together the two form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274159 [Multi-domain] Cd Length: 579 Bit Score: 668.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 147 RENANVDGNSAMGSMLRYGTESAKQFNLLEVLDPTHAAAHRDGDIHIHDLDF-LTLTTTCCQINLTDLFEHGFSTGHGVL 225
Cdd:TIGR02487 1 NENANMDSPTPSTQRKLIASEVSKDYALLHLLPKDIARAHLNGDIHIHDLDYaLTLTTNCCLHDLRNLLKYGFRTGNIVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 226 RAPQSIGSYAALACIAIQSNQNDQHGGQAVPNFDRDMAPGVAKTFVKaaqtgltrtfevlggdeeyldevreaasgwvle 305
Cdd:TIGR02487 81 KPPKHIDVALNHIVNILQSLQNEQYGGQSFPEFDTLLAPYIEKTNLK--------------------------------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 306 pdgaalahEKEQVAKLFaGLIDDTDRVAdrvrrqaVEETRRQTYQAMEALIANLNTMNSRAGaQTPFSSINYGTDTSPEA 385
Cdd:TIGR02487 128 --------HRKVLQQLQ-LLLFEATEYA-------ARRTFTDVTQAMQGPEYNPNTLHSAGG-QTPFESIGYGTETSKEG 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 386 RMVMHCLLEATEAGLGGGETAIFPIQIFRVQKGVNLDDDDPnHDLFRLACRVSAKRLFPNFSFQDAPFNAEYYVPghpet 465
Cdd:TIGR02487 191 RMIAKALLDVRMEGDGKGEPFIFPKIIFKVREGFNWDEPDP-YDLFELAFECAAKRGYPYFLNLDPEDNVKEDVR----- 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 466 eiAYMGCRTRVMSNVHDPSRAQTWGRGNLSFTSINLPRLAIEANHDVNAFFTSFDRMIDLVIDQLLDRLKIQSHKLVRNF 545
Cdd:TIGR02487 265 --YPMGCRTFLSPNENGDGEESYIGRGNIGVTSINLPRIAYKSRGDEEEFFEELDEYLEIAKEALEIRREYLKKMLAKDL 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 546 PFLMGQGVWIGSENLgpDDAVAEVLEHGTLSVGFIGLAETLTALVGVHHGESEEAQQLGLRIVGHLRERMDEAAERTGLN 625
Cdd:TIGR02487 343 PPMYSQGGWDGGNLL--DESVEEILKSGTNSIGFIGLNEALVALTGKHLHEEEEARELAIRILEFIRDKADEFKKETGLN 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 626 FSALATPAEGLSGRFVRMDRQRYGSIPGVTDREYYTNSFHVPVWYHIGAADKIRIEAPYHAFTNGGHISYVELSGDpARN 705
Cdd:TIGR02487 421 YSVYATPAESLCGRFAKKDREEFGEIPGVTDKPYYTNSFHVPVYEDVNLGEKIDIEAPFHPLTNGGHITYIELDEA-IPD 499
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 706 VDAFETLVRYMAASGIGYGSINHPVDRDPQCGYTGIID-DECPKCGRHEdsgsFDRIRRITGYLvGGLDRFNDAKRAEVR 784
Cdd:TIGR02487 500 PEALKDITKKAMKNGIGYFGINPPVDVCEDCGYTGEGLnDKCPKCGSHD----IEVISRITGYL-GPVENWNDGKQAEFK 574
|
....*
gi 550741585 785 DRVKH 789
Cdd:TIGR02487 575 DRKKH 579
|
|
| RNR_III |
cd01675 |
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
148-770 |
0e+00 |
|
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.
Pssm-ID: 153084 [Multi-domain] Cd Length: 555 Bit Score: 649.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 148 ENANVDgNSAMGSMLRYGTESAKQFNLLEVLDPTHAAAHRDGDIHIHDLDFLTLTTTCCQINLTDLFEHGFSTGHGVLRA 227
Cdd:cd01675 1 ENANVD-SSPGSTMKDLAAGIVKKYYLLKILPKEIARAHLNGDIHIHDLDYLPLTPYCCGWDLRPLLEKGFTTGNGIIEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 228 PQSIGSYAALACIAIQSNQNDQHGGQAVPNFDRDMAPGVAKTFVKAAQTGltrtfevlggdeeyldevreaasgwvlepd 307
Cdd:cd01675 80 PKHLSSALGHIVNFLGTVQNEQAGGQAFPEFDTYLAPFVRKDYLKYRLTA------------------------------ 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 308 gaalahekeqvaklfagliddtdrvadrvrrqaveeTRRQTYQAMEALIANLNTMnSRAGAQTPFSSINYG--------- 378
Cdd:cd01675 130 ------------------------------------TRKEIKQAMQGFIYNLNTL-SRRGGQTPFTNITLGlvcpkdlef 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 379 ----------TDTSPEARMVMHCLLEATEAGLGGGETAIFPIQIFRVQKGVNLDdddPNHDLFRLACRVSAKRLFPNFSF 448
Cdd:cd01675 173 egggepvftyGDTDKEARMIQKAFLEVRLEGDAKGRPFTFPIPTFNVTEGFNLD---PNYDLKELAFECAAKRGYPYFLN 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 449 QDAPFNAEYYVpghpeteiAYMGCRTRVMSNVHDPS---RAQTWGRGNLSFTSINLPRLAIEANHDVNAFFTSFDRMIDL 525
Cdd:cd01675 250 FDNSDNVPGDV--------RAMGCRLFLDKNELKRGgglEGSGDGTGNIGVVTINLPRIAYEARGDEEKFFELLDEYLEL 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 526 VIDQLLDRLKIQSHKLVRNFPFLMGQGVWIGSEnlgpddavAEVLEHGTLSVGFIGLAETLTALVGVHHGESEEAQQLGL 605
Cdd:cd01675 322 AKDALEIRRKRLKEALARGLPPLYQEGLGGGKL--------LFILKRHTLTIGFIGLNEAAEALTGKGIGESEEAREFGI 393
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 606 RIVGHLRERMDEAAERTGLNFSALATPAEGLSGRFVRMDRQRYGS-IPGVTDREYYTNSFHVPVWYHIGAADKIRIEAPY 684
Cdd:cd01675 394 RILEHIRERADEFKEETGLLYSVEATPAESLAYRFAKKDRKKYGDiIPGVTDKPYYTNSFHVPVYEDIDPFEKIDIEAKL 473
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 685 HAFTNGGHISYVELsGDPARNVDAFETLVRYMAASGIGYGSINHPVDRDPQCGYTG-IIDDECPKCGRHEdsgsFDRIRR 763
Cdd:cd01675 474 HPLTTGGHILHIEL-GEAKPNPEALEALVKKAAKRGVIYFGINTPIDICNDCGYIGeGEGFKCPKCGSED----VEVISR 548
|
....*..
gi 550741585 764 ITGYLVG 770
Cdd:cd01675 549 ITGYLGP 555
|
|
| PRK09263 |
PRK09263 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
34-789 |
1.86e-168 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236436 [Multi-domain] Cd Length: 711 Bit Score: 503.26 E-value: 1.86e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 34 KRDGRVIGFDSTKIVEAVRKAFVACGIDaPELLASEVALEVLSRLSemGEDTPDVEAIQDLVEKALMDQGHDDVAKAYIL 113
Cdd:PRK09263 7 KRDGRKVPFDSEKIKNAIEKAAKAVEVD-DEDYCATVAAEIASRVE--GRDEVDIEEIQDAVENQLMAGPYKALARAYIE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 114 YRQRRTVARDQQSALMRTLREITfaSAEEADAKRENANVDGNsamgsmlRYGT-------ESAKQFNLLEVLdPTH-AAA 185
Cdd:PRK09263 84 YRHDRDIAREKATDLNEEIRGLI--EQSNEAVLNENANKDSK-------VFSTqrdllagIVSKHYALRHLL-PRDvVNA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 186 HRDGDIHIHDLDFLTLT--TTCCQINLTDLFEHGFSTGHGVLRAPQSIGSYAALACIAIQSNQNDQHGGQAVPNFDRDMA 263
Cdd:PRK09263 154 HEKGDIHYHDLDYSPFFpmFNCCLIDLKGMLTNGFKIGNAEIESPKSIQTATAVTAQIIAQVASSQYGGCTINRIDEVLA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 264 PGVAKTFVKaaqtgltrtfevlggdeeYLDEVREaasgWVLEPDGAALAHEKeqvaklfagliddtdrvadrvrrqavee 343
Cdd:PRK09263 234 PYAEKSYEK------------------HLKDAEE----WVIEEKAEAYARAR---------------------------- 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 344 TRRQTYQAMEALIANLNTMNSRAGaQTPFSSINYGTDTSPEARMVMHCLLEATEAGLGG-GETAIFPIQIFRVQKGVNLD 422
Cdd:PRK09263 264 TEKEIYDAMQSLEYEINTLHTSNG-QTPFVTLGFGLGTSWESRLIQKAILRNRIAGLGKeRKTAIFPKLVFAIKDGLNLK 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 423 DDDPNHDLFRLACRVSAKRLFPNFSFQDA--PFNAEYYVPghpeteiayMGCRtrvmsnvhdpSRAQTW----------G 490
Cdd:PRK09263 343 PGDPNYDIKQLALECATKRMYPDILNYDKivELTGSFKTP---------MGCR----------SFLQGWkdengeevhdG 403
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 491 RGNLSFTSINLPRLAIEANHDVNAFFTSFDRMIDLVIDQLLDRLKIQSHKLVRNFPFLMGQGVwIGsENLGPDDAVAEVL 570
Cdd:PRK09263 404 RNNLGVVTLNLPRIALEAKGDEDKFWEILDERLELAKKALMTRIERLKGAKPRVAPILYMYGA-FG-VRLKADDDVDELF 481
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 571 EHG--TLSVGFIGLAETLTALVGVHHGESEEAQQLGLRIVGHLRERMDEAAERTGLNFSALATPAEGLSGRFVRMDRQRY 648
Cdd:PRK09263 482 KNGraTISLGYIGLYETINALYGGSWEVNPEAKAFALAIVKRMKDACDQWKKETGYGFSLYSTPSESLTDRFCRLDTEKF 561
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 649 GSIPGVTDREYYTNSFHVPVWYHIGAADKIRIEAPYHAFTNGGHISYVELSgDPARNVDAFETLVRYmAASGIGYGSINH 728
Cdd:PRK09263 562 GVIPGITDKGYYTNSFHYDVRKKVNPFEKLDFEKPYPPLASGGFIHYCEYP-NLQHNLKALEAVWDY-SYDRVGYLGTNT 639
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550741585 729 PVDRDPQCGYTG---IIDD--ECPKCGRHeDSGSFDRIRRITGYLVGGLDR-FNDAKRAEVRDRVKH 789
Cdd:PRK09263 640 PIDECYECGFTGefeCTEKgfTCPKCGNH-DPKTVSVTRRTCGYLGNPDARpFNHGRQEEIKRRVKH 705
|
|
| PRK08270 |
PRK08270 |
ribonucleoside triphosphate reductase; |
28-670 |
8.98e-67 |
|
ribonucleoside triphosphate reductase;
Pssm-ID: 236212 [Multi-domain] Cd Length: 656 Bit Score: 233.97 E-value: 8.98e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 28 VPASIRKRDGRVIGFDSTKIVEAVRKAFVACGIDAPELlASEVALEVLSRLSEmgEDTPDVEAIQDLVEKALMDQGHDDV 107
Cdd:PRK08270 1 MPTKIIKRDGRIVPFDAEKITEAIAKAFKATGEFDPSE-AERLALRVIEKLED--EDIPSVEEIQDIVEKVLIEAGYFKT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 108 AKAYILYRQRRTVARDQQSALMRTLREItfasaEE----ADAK-RENANVdGNSAMGSMLRYGTESAKQFNLLEVLDPTH 182
Cdd:PRK08270 78 AKAYILYREQHARLRNDKKTLLDVEDTV-----DEyldrEDWRvNENSNM-GYSLQGLILNISGKVTANYWLNKVYPPEI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 183 AAAHRDGDIHIHDLDFLTLttTCCQINLTDLFEHGFStghGVlraPQSIGS------YAALACIAiqsN-----QNDQHG 251
Cdd:PRK08270 152 GEAHRNGDLHIHDLDMLSG--YCAGWSLRDLLLEGFN---GV---PGKVESkppkhfRSALGQIV---NflgtlQNEWAG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 252 GQAVPNFDRDMAPgvaktFVKAaqTGLTrtfevlggdeeYlDEVReaasgwvlepdgaalahekeqvaklfagliddtdr 331
Cdd:PRK08270 221 AQAFSSFDTYLAP-----FVRK--DGLS-----------Y-KEVK----------------------------------- 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 332 vadrvrrqaveetrrqtyQAMEALIANLNTmNSRAGAQTPFSSI------------------------NYGtDTSPEARM 387
Cdd:PRK08270 247 ------------------QAIQEFVFNLNV-PSRWGFQTPFTNLtfdltvpedlkdqpviiggeemdfTYG-DFQKEMDM 306
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 388 VMHCLLEATEAGLGGGETAIFPIQIFRVQKgvNLDDDDPNHD-LFRLACRVSAKrLFPNFsfqdapFNAEyYVPGHpete 466
Cdd:PRK08270 307 INRAFIEVMLEGDANGRVFTFPIPTYNITK--DFDWDSENADlLFEMTAKYGLP-YFQNF------INSD-LKPED---- 372
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 467 IAYMGCRTRVmsnvhDPSRAQTwgRGNLSFTS-----------INLPRLAIEAnHDVNAFFTSFDRMIDL---------- 525
Cdd:PRK08270 373 VRSMCCRLQL-----DLRELRK--RGGGLFGSaeltgsigvvtINLPRLGYLS-KDEEEFFARLDELMDLakdsleikrk 444
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 526 VIDQLLDR-LkiqshklvrnFPF----LmgqgvwigsenlgpddavaevlehGTL-----SVGFIGLAETLTALVGvHHG 595
Cdd:PRK08270 445 VIERLTDKgL----------YPYtkryL------------------------GTLrnhfsTIGLNGMNEACLNFLG-KDI 489
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550741585 596 ESEEAQQLGLRIVGHLRERMDEAAERTGLNFSALATPAEGLSGRFVRMDRQRYGSI--PGVTDREYYTNSFHVPVWY 670
Cdd:PRK08270 490 TTEEGRAFALRVLDHMRERLVEFQEETGNLYNLEATPAEGTTYRLAKEDKKRYPDIitAGTDEEPYYTNSTQLPVGY 566
|
|
| ATP-cone |
pfam03477 |
ATP cone domain; |
32-120 |
1.41e-23 |
|
ATP cone domain;
Pssm-ID: 397513 [Multi-domain] Cd Length: 86 Bit Score: 95.02 E-value: 1.41e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 32 IRKRDGRVIGFDSTKIVEAVRKAFVACGIDApellaSEVALEVLSRLSEMGEDTPDVEAIQDLVEKALMDQGHDDVAKAY 111
Cdd:pfam03477 3 VIKRDGRREPFDKEKIRRAIEKACEKSPDQA-----DELASEVEEELEKSLEDGISTEEIQDLVEKTLAEHPDYAVARAY 77
|
....*....
gi 550741585 112 ILYRQRRTV 120
Cdd:pfam03477 78 ILYRNLRKE 86
|
|
| PRK08579 |
PRK08579 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
345-789 |
5.80e-20 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 236303 [Multi-domain] Cd Length: 625 Bit Score: 94.82 E-value: 5.80e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 345 RRQTYQAMEALIANLNtMNSRAGAQTPFSSINYGTDTSP-----------------------EARMVMHCLLEATEAGLG 401
Cdd:PRK08579 149 YRKIKQNIQRLVYNLN-YPSRVGMQTPFTNFTVTLDAPKkmlegdyavydgkkvgplgeyeeEAKLFLLALTEVLREGDA 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 402 GGETAIFPIQIFRVQKgvNLDDDDPnhDLFRLACRVSAKR-----LFPNFSFQDAPFN--AEYYVPGHpETEIAYMGcRT 474
Cdd:PRK08579 228 LGQPFTFPIPTLMTTA--KMLWDDP--EVFEAVFTTAAKRgsfywLNTRVVDPDASYAmcCRINIDKN-ELMYAFGV-GG 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 475 RVMSNVHDpSRAQTWGR----------------GNLSFTSINLPRLAIEANHDVNAFFTSFDRMIDLVIDqLLDRLKIQS 538
Cdd:PRK08579 302 KSRRDLED-AEEEYLEKlekqrfgglwampditGSVNVTTVNLPRIALEARGDDDKFWELYEERLELVRI-TLDWFRERY 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 539 HKLVRNFPFLMGQgvwigsenlgpddaVAEVLEHGTLS----VGFIGLAETLTALVGV-------HHGESEEAQQLGLRI 607
Cdd:PRK08579 380 VKLLKTYPEMYSM--------------IKEYLEEFPSShfntIGIIGLPEAAAIYLGEpklwtegSRRDWLEAAELMKKM 445
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 608 VGHLRERMDEAAERTGLNFSALATPAEGLSGRFVRMDRQRYgsiPGVtdREY--------YTNSFhVPVWYHIGAADKIR 679
Cdd:PRK08579 446 VEFAVEKAREWMKETGTPWNVEEVPGESAAAKLAIKDLKLF---PEL--REYlsdpenpiYSTSI-APYYGPLELWDRIE 519
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 680 IEAPYHAFTNGGHISYVELSGDParNVDAFETLVRYMAASGIGYGSINHPVDRDPQCG--YTGIIdDECPKCGRHEdsgs 757
Cdd:PRK08579 520 IEEKVQQEFTGGVMMHIFLGEEP--DPEALAKLTKRIMNTKLVYWSYTPAITVCNKCGrsTTGLY-TRCPRCGSED---- 592
|
490 500 510
....*....|....*....|....*....|..
gi 550741585 758 FDRIRRITGYLvGGLDRFNDAKRAEVRDRvKH 789
Cdd:PRK08579 593 VEVWSRIIGYY-RPLKNWNPYRKKEFWLR-KH 622
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
32-139 |
1.35e-16 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 84.42 E-value: 1.35e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 32 IRKRDGRVIGFDSTKIVEAVRKAFVACGIDAPELLASEVALEVLSRLSEMGED--TPDVEAIQDLVEKALMDQGHDDVAK 109
Cdd:PRK12364 3 IIKRNGTTEPYDREKIEVAIRKAFASVGKPISDEIIYSLVAEVERFIKEKYPNghNVSVEEIQDLVEKTLMEHGHYAEVK 82
|
90 100 110
....*....|....*....|....*....|
gi 550741585 110 AYILYRQRRTVARDQQSALMRTLREITFAS 139
Cdd:PRK12364 83 SYILYRAQRTEKRKAREQIIKFFDDDTVLG 112
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
31-125 |
5.55e-16 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 82.69 E-value: 5.55e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 31 SIRKRDGRVIGFDSTKIVEAVRKAFVAC----GIDAPELLASEVAL------EVLSRLSEmgEDTPDVEAIQDLVEKALM 100
Cdd:PRK12365 119 SVIRRDGTVVHFNPMKISAALEKAFRATdkieGMTPSSVLEEINALtqniveEILECCSQ--EDRIDIEKIQDIVEQQLM 196
|
90 100
....*....|....*....|....*
gi 550741585 101 DQGHDDVAKAYILYRQRRTVARDQQ 125
Cdd:PRK12365 197 VVGHYDVAKNYILYREARARVRDNK 221
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
9-127 |
1.51e-15 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 81.16 E-value: 1.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 9 SISHPVSISHPVSISQQRAVPAS--------IRKRDGRVIGFDSTKIVEAVRKAFVAC-GIDAPellASEVALEVLSRLS 79
Cdd:PRK07207 5 TQEESAASRPLAAASQGALAAAApgqladykVIRRNGSVVPFEPSKIAVAMTKAFLAVeGGQAA---ASARVRETVEQLT 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 550741585 80 EM----------GEDTPDVEAIQDLVEKALMDQGHDDVAKAYILYRQRRTVARDQQSA 127
Cdd:PRK07207 82 EQvvralvrrrpSGGTFHIEDIQDQVELALMRSGEHKVARAYVLYREKRAQERAAEAE 139
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
29-128 |
6.36e-15 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 78.74 E-value: 6.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 29 PASIRKRDGRVIGFDSTKIVEAVRKAFVACG-IDAPEllASEVALEVLSRLSEmgEDTPDVEAIQDLVEKALMDQGHD-- 105
Cdd:PRK06406 4 VKEVIKRDGTVVPFDKKKIAMAIYKAMLSVKnGSMED--AEELTDKVVERLKK--YERPTVEQIQDIVEKVLMTKKINgk 79
|
90 100
....*....|....*....|....*.
gi 550741585 106 ---DVAKAYILYRQRRTVARDQQSAL 128
Cdd:PRK06406 80 dftDVAKSYILYREKRRKIREEKELI 105
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
32-135 |
1.68e-14 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 77.88 E-value: 1.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 32 IRKRDGRVIGFDSTKIVEAVRKAFVACGIDAPELLaSEVALEVLSRLSEMGE-DTPDVEAIQDLVEKALMDQGHDDVAKA 110
Cdd:PRK08332 6 VMKRDGRIVPFDESRIRWAVQRAMWEVGVRDEKKL-DEVVKRIVQRINELYDgKIPHIENIQDIVELELMRAGLFEVAKA 84
|
90 100
....*....|....*....|....*..
gi 550741585 111 YILYRQRRTVARDQQSALM--RTLREI 135
Cdd:PRK08332 85 YILYRKKKAEIREEKKRILnkKELDEI 111
|
|
| PRK08271 |
PRK08271 |
anaerobic ribonucleoside triphosphate reductase; Provisional |
470-790 |
5.94e-14 |
|
anaerobic ribonucleoside triphosphate reductase; Provisional
Pssm-ID: 181342 [Multi-domain] Cd Length: 623 Bit Score: 75.43 E-value: 5.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 470 MGCRTRvmSNVHDPSRAQTWGRGNLSFTS-----INLPRLAIEANhDVNAFFTSFDRMIDLVIDQLLDRLKIQSHKLVRN 544
Cdd:PRK08271 324 SCCRLR--NEISDNGFSYSLGAGGVNTGSinvitINLPRIAQEAR-DRDDFLEILRERVDKIHKYQLAYREIMEERIAAG 400
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 545 FPFLMGQGvWIGsenlgpddavaevLEHGTLSVGFIGLAETLTALvGVHHGESEEAQQLGLRIVGHLRERMDEAAERTGL 624
Cdd:PRK08271 401 MLPLYDAG-FIS-------------LDKQFLTIGINGMVEAAEFM-GLTVGYNEEYKDFVQEVLKVIYEANEKASKEYGF 465
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 625 NFSALATPAEGLSGRFVRMDRQ-RYGsipgvTDREYYTNSFHVPVWYHIGAADKIRIE-APYHAFTNGGHISYVELsgDP 702
Cdd:PRK08271 466 TFNTEFVPAENLGVKLAKWDREdGYG-----VPRQCYNSYSYVVEDANTDALDKFKLHgKELDKYLSGGSALHLNL--DE 538
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 703 ARNVDAFETLVRYMAASGIGYGSINHPVDRDPQCGYTGI-IDDECPKCGRHEDsgsfDRIRRITGYLVgGLDRFNDAKRA 781
Cdd:PRK08271 539 RLSEEGYRKLLNIAAKTGCNYFAFNVKITICNDCHHIDKrTGKRCPICGSENI----DYYTRVIGYLK-RVSAFSKVRQK 613
|
....*....
gi 550741585 782 EVRDRVKHG 790
Cdd:PRK08271 614 EYPRRHYHR 622
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
31-133 |
7.15e-07 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 53.03 E-value: 7.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 31 SIRKRDGRVIGFDSTKIVEAVRKAF-----VACGIDAPELLAS-------EVALEVLSRLSEMGEDTpdVEAIQDLVEKA 98
Cdd:PRK12365 10 TIVKRNGMFVPFNQNRIFQALEAAFrdtrsLEDHSPLPEDLESsirsithQVVKEVVQKITEGQVVT--VERIQDMVESQ 87
|
90 100 110
....*....|....*....|....*....|....*
gi 550741585 99 LMDQGHDDVAKAYILYRQRRTVARDQQSALMRTLR 133
Cdd:PRK12365 88 LYVNGLQDVARDYIVYRDDRKAHRKKSWQSLSVIR 122
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
331-727 |
9.35e-06 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 48.68 E-value: 9.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 331 RVADRVRRQAVEETRRQTYQAMEALIANLNTMNSRAGaQTPFSSINYGTDTSPEARMVMHCLLEATEAGLGGGETAIFPI 410
Cdd:cd00576 81 SPYGSRDYAKGSGTETDAVEAADAFNLALKEVGQGNG-RTGAATGFIGGVHKGKGDKISQEFLNLALANGGEGIPLNFPN 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 411 QIFRVQKGVNLdDDDPNHDLFRLACRVSAKRLFPNFsfqdapFNAEyyvpghpeteiaymgcrtrvmsnvhdpsrAQTWG 490
Cdd:cd00576 160 LSVRVSSDKPG-ILVKAVELKQLIAEEARKTGSPGI------FNDE-----------------------------LCNLV 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 491 RGNlsftsinlprLAIEANHDVNAFFTSFDRMIDLVIDQLLDRLK--IQSHKlvrnfpflmgqgVWIGSENLGPDdavae 568
Cdd:cd00576 204 SLN----------LARIMEKAINGSMDVVLEELEELAFLAVRALDcvIDSHD------------ERIPTIELGGD----- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 569 vlEHGTLSVGFIGLAETLtALVGVHHGESEEAQQLGLRIVGHLRERMDEAAERTGLNFSALATPAEGLSgrfvrmdrqry 648
Cdd:cd00576 257 --ERRTVGLGIAGVADLL-IKLGLEKVGDPEADDLAAELVDQLKKHLVKATNERGFNFLLGLSPSESNS----------- 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550741585 649 gsipgvtDREYYTNSFHVP-------VWYHIGAADKIRIEAPYHAFTNGGHISYVELSgDPARNVDAFETLVRYMAASGI 721
Cdd:cd00576 323 -------SGAPATNGVSPSrg*iaivLNGDIGPEESLASVAILQFYADNGISDTITIP-DSATNLDQLLAVIDGAAAIKT 394
|
....*.
gi 550741585 722 GYGSIN 727
Cdd:cd00576 395 THVRVN 400
|
|
| |
