|
Name |
Accession |
Description |
Interval |
E-value |
| thrB |
TIGR00191 |
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ... |
2-308 |
2.43e-167 |
|
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 129295 [Multi-domain] Cd Length: 302 Bit Score: 466.49 E-value: 2.43e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 2 VKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAETfSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQI- 80
Cdd:TIGR00191 1 FRVKVPASSANLGPGFDVLGAALSLYLGLTVTDVVAQESDDT-EIEAEGEGVEKIPTEPTDNLIYQVAKRFLDQLGIRMp 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 81 PVAMALEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGrisgsiHYDNVAPCFLGGMQLMIEEND- 159
Cdd:TIGR00191 80 PVKVTLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEG------HPDNVAPALLGGFQLAFVEDDk 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 160 IISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLL 239
Cdd:TIGR00191 154 LEVLKIPIFSKLDWVLAIPNIEVSTAEARAVLPKAYPRQDLVFNLSHLAGLVHAIYQKKPDLGAIMMKDRIHQPYRESLI 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 431712160 240 PGFRQARQAVAEIGAVASGISGSGPTLFALCDKPDTAQRVADWLGKNYLQNQEGFVHICRLDTAGARVL 308
Cdd:TIGR00191 234 PNLFKIKQAALEKGAYGITISGSGPTILAMADEEFAEQKEQDLLEVLHKQGIEGTVHVLDFDNDGARVE 302
|
|
| PRK01212 |
PRK01212 |
homoserine kinase; Provisional |
1-308 |
9.85e-163 |
|
homoserine kinase; Provisional
Pssm-ID: 234920 [Multi-domain] Cd Length: 301 Bit Score: 454.99 E-value: 9.85e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 1 MVKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEaaETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQI 80
Cdd:PRK01212 3 MVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSVE--AEFSIEVIGEGADKLPLDPEKNLVYQAALKFLEKLGKPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 81 PVAMALEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGrisgsiHYDNVAPCFLGGMQLMIEENDI 160
Cdd:PRK01212 81 GLRIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEG------HPDNVAPALLGGLVLALEENGV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 161 ISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLP 240
Cdd:PRK01212 155 ISVKIPVFDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAMKDVLHEPYRAKLIP 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 431712160 241 GFRQARQAVAEIGAVASGISGSGPTLFALCDKPDtAQRVADWLGKNYLQNQEGFVHICRLDTAGARVL 308
Cdd:PRK01212 235 GFAEVRQAALEAGALGAGISGAGPTVFALCDKED-AEKVADALQKAFLQGIEGFVHVLRLDTAGARVL 301
|
|
| ThrB |
COG0083 |
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ... |
1-309 |
4.67e-133 |
|
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 439853 [Multi-domain] Cd Length: 302 Bit Score: 379.83 E-value: 4.67e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 1 MVKVYAPASSANMSVGFDVLGAAVTpvdgalLGDVVTVEAAET--FSLNNLGRFADKLPSEPrENIVYQCWERFCQELGK 78
Cdd:COG0083 2 SVKVRVPATSANLGPGFDSLGLALS------LYDEVEVERSDEpgLEIEIEGEGADELPTDE-DNLVYQAALALLEKLGK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 79 QIP-VAMALEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGrisgsiHYDNVAPCFLGGMQLMI-E 156
Cdd:COG0083 75 EPPgLRIEIEKGIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEG------HPDNVAPALLGGLVLSRsD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 157 ENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRE 236
Cdd:COG0083 149 GEPVRVVRLPVPPDLKAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAMEDRLHEPYRA 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 431712160 237 RLLPGFRQARQAVAEIGAVASGISGSGPTLFALCDKPDtAQRVADWLGKNYLQNQEGF-VHICRLDTAGARVLE 309
Cdd:COG0083 229 KLIPGFDEVKEAALEAGALGAGISGAGPTVLALADDEE-AEAVAEAMKAAFAEAGIDArVYVLKIDNEGARVLE 301
|
|
| GHMP_kinases_N |
pfam00288 |
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ... |
84-150 |
9.35e-13 |
|
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.
Pssm-ID: 395225 [Multi-domain] Cd Length: 64 Bit Score: 62.18 E-value: 9.35e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 431712160 84 MALEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDtrlLALMGELEgRISGSIHYDNVAPCFLGG 150
Cdd:pfam00288 2 IEIESNIPLGAGLGSSAALAVALLLALNELFGLPLAK---LALEAEEL-AGGGRGGGMDVAASLYGG 64
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| thrB |
TIGR00191 |
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ... |
2-308 |
2.43e-167 |
|
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 129295 [Multi-domain] Cd Length: 302 Bit Score: 466.49 E-value: 2.43e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 2 VKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAETfSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQI- 80
Cdd:TIGR00191 1 FRVKVPASSANLGPGFDVLGAALSLYLGLTVTDVVAQESDDT-EIEAEGEGVEKIPTEPTDNLIYQVAKRFLDQLGIRMp 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 81 PVAMALEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGrisgsiHYDNVAPCFLGGMQLMIEEND- 159
Cdd:TIGR00191 80 PVKVTLEKNIPLGRGLGSSAAAIVAALAAANELCGLPLSKERLLDYASELEG------HPDNVAPALLGGFQLAFVEDDk 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 160 IISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLL 239
Cdd:TIGR00191 154 LEVLKIPIFSKLDWVLAIPNIEVSTAEARAVLPKAYPRQDLVFNLSHLAGLVHAIYQKKPDLGAIMMKDRIHQPYRESLI 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 431712160 240 PGFRQARQAVAEIGAVASGISGSGPTLFALCDKPDTAQRVADWLGKNYLQNQEGFVHICRLDTAGARVL 308
Cdd:TIGR00191 234 PNLFKIKQAALEKGAYGITISGSGPTILAMADEEFAEQKEQDLLEVLHKQGIEGTVHVLDFDNDGARVE 302
|
|
| PRK01212 |
PRK01212 |
homoserine kinase; Provisional |
1-308 |
9.85e-163 |
|
homoserine kinase; Provisional
Pssm-ID: 234920 [Multi-domain] Cd Length: 301 Bit Score: 454.99 E-value: 9.85e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 1 MVKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEaaETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQI 80
Cdd:PRK01212 3 MVKVRVPATSANLGPGFDSLGLALSLYDEVLVGDVVSVE--AEFSIEVIGEGADKLPLDPEKNLVYQAALKFLEKLGKPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 81 PVAMALEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGrisgsiHYDNVAPCFLGGMQLMIEENDI 160
Cdd:PRK01212 81 GLRIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLATEGEG------HPDNVAPALLGGLVLALEENGV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 161 ISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLP 240
Cdd:PRK01212 155 ISVKIPVFDDLKWVVAIPNIELSTAEARAVLPKQYSLKDAVFNSSRAALLVAALYTGDYELAGRAMKDVLHEPYRAKLIP 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 431712160 241 GFRQARQAVAEIGAVASGISGSGPTLFALCDKPDtAQRVADWLGKNYLQNQEGFVHICRLDTAGARVL 308
Cdd:PRK01212 235 GFAEVRQAALEAGALGAGISGAGPTVFALCDKED-AEKVADALQKAFLQGIEGFVHVLRLDTAGARVL 301
|
|
| ThrB |
COG0083 |
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ... |
1-309 |
4.67e-133 |
|
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 439853 [Multi-domain] Cd Length: 302 Bit Score: 379.83 E-value: 4.67e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 1 MVKVYAPASSANMSVGFDVLGAAVTpvdgalLGDVVTVEAAET--FSLNNLGRFADKLPSEPrENIVYQCWERFCQELGK 78
Cdd:COG0083 2 SVKVRVPATSANLGPGFDSLGLALS------LYDEVEVERSDEpgLEIEIEGEGADELPTDE-DNLVYQAALALLEKLGK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 79 QIP-VAMALEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGrisgsiHYDNVAPCFLGGMQLMI-E 156
Cdd:COG0083 75 EPPgLRIEIEKGIPLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELATEGEG------HPDNVAPALLGGLVLSRsD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 157 ENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRE 236
Cdd:COG0083 149 GEPVRVVRLPVPPDLKAVVVIPDFELSTKEARAVLPKQVPLKDAVFNSSRAALLVAALATGDYELLGRAMEDRLHEPYRA 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 431712160 237 RLLPGFRQARQAVAEIGAVASGISGSGPTLFALCDKPDtAQRVADWLGKNYLQNQEGF-VHICRLDTAGARVLE 309
Cdd:COG0083 229 KLIPGFDEVKEAALEAGALGAGISGAGPTVLALADDEE-AEAVAEAMKAAFAEAGIDArVYVLKIDNEGARVLE 301
|
|
| PLN02451 |
PLN02451 |
homoserine kinase |
2-310 |
5.10e-43 |
|
homoserine kinase
Pssm-ID: 215248 Cd Length: 370 Bit Score: 151.48 E-value: 5.10e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 2 VKVYAPASSANMSVGFDVLGAAVtpvDGalLGDVVTVEAAETF-----SLNNLGRFADKLPSEPRENIVYQCWERFCQEL 76
Cdd:PLN02451 54 VKAFAPATVANLGPGFDFLGCAV---DG--LGDFVTARVDPGVrpgevSISEITGDTGRLSKDPLRNCAGIAAIATMKLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 77 G-KQIPVAMALEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGRISGsIHYDNVAPCFLGGMQLM- 154
Cdd:PLN02451 129 GiRSVGLSLSLHKGLPLGSGLGSSAASAAAAAVAVNELFGSPLGKDDLVLAGLESEAKVSG-YHADNIAPALMGGFVLIr 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 155 -IEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAK-LMKDVIAE 232
Cdd:PLN02451 208 sYEPLHLIPLRFPSAKDLFFVLVSPDFEAPTKKMRAALPKEIPMKHHVWNCSQAAALVAAILQGDAVLLGEaLSSDKIVE 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 233 PYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFALCDKPDTAQRVADWLGKNYLQ--NQEGFVHICRLDTAGARVLEN 310
Cdd:PLN02451 288 PTRAPLIPGMEAVKKAALEAGAYGCTISGAGPTAVAVIDDEEKGEEVGERMVEAFRKagNLKATASVKKLDRVGARLVES 367
|
|
| IspE |
COG1947 |
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ... |
24-287 |
1.36e-33 |
|
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Pssm-ID: 441550 [Multi-domain] Cd Length: 281 Bit Score: 124.46 E-value: 1.36e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 24 VTPVDgalLGDVVTVEAAETFSLNNLGRFADkLPsEPRENIVYQCWERFCQELGKQIPVAMALEKNMPIGSGL--GSS-- 99
Cdd:COG1947 31 FQFID---LGDTLTIEPADDGSISLTGPGAG-VP-TDEDNLVYRAARLLQEATGIPPGVDIHLEKRIPVGAGLggGSSda 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 100 AcsvvAALMAMNEHCGKPLNDTRLLALMGELegrisGSihyDnVAPCFLGGMQLMIEENDIIsQQVPGFDEWLWVLAYPG 179
Cdd:COG1947 106 A----ATLRALNRLWGLGLSREELAELAAKL-----GA---D-VPFFLYGGTALAEGRGEKL-TPLPPLPELWLVLVKPG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 180 IKVSTAEArailpaqYRRQDC--IAHGRHLAGFIHACYSRQPELAAKLMKDViaEPYRERLLPGFRQARQAVAEIGAVAS 257
Cdd:COG1947 172 VGVSTAEV-------YRALDLtrDTPPPDIDALLAALAAGDAALAALLRNDL--EPVAFKLYPEIAEVLEALLEAGALAA 242
|
250 260 270
....*....|....*....|....*....|
gi 431712160 258 GISGSGPTLFALCDKPDTAQRVADWLGKNY 287
Cdd:COG1947 243 RMSGSGSTVFGLFEDEEAAEAAAAALPARG 272
|
|
| PTZ00299 |
PTZ00299 |
homoserine kinase; Provisional |
2-269 |
1.14e-20 |
|
homoserine kinase; Provisional
Pssm-ID: 140320 Cd Length: 336 Bit Score: 90.33 E-value: 1.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 2 VKVYAPASSANMSVGFDVLGAAVTpvdgalLGDVVTVEAAETFSLNNLGRFADKLpSEPRENIVYQCWERFCQELGKQI- 80
Cdd:PTZ00299 8 VVLRVPATTANIGPAYDTLGMALS------IFMELTVEHADAFSMTVEGEGSEHI-STDEDNMVVQACRLAFEEYAHKSm 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 81 -PVAMALEKNMPIGSGLGSSACSVVAALMAMNEHCGKPL---NDTRLLALMGELEGrisgsiHYDNVAPCFLGGMQLMIE 156
Cdd:PTZ00299 81 pPLKFIMHSNIPYGCGCGSSSAAAVAGFVAGMKLCGLTMeteNEEALLQAIAKFEG------HPDNAAPAIYGGIQLVYK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 157 END--IISQQVPGFDEWLWVLAYPG--IKVSTAEARAILPAQYRRQDCIaHGRHLAGFIHACYSRQPELAAKLMKDVIAE 232
Cdd:PTZ00299 155 KDNgrFLTYRVPTPPNLSVVLFVPHnkMKANTHVTRNLIPTSVSLEDAV-FNISRTSILVLALSTGDLRMLKSCSDKLHE 233
|
250 260 270
....*....|....*....|....*....|....*...
gi 431712160 233 PYRER-LLPGFRQARQAVAEIGAVASGISGSGPTLFAL 269
Cdd:PTZ00299 234 QQRSDaLFPHFRPCVKAAREAGAHYAFLSGAGPSVCAL 271
|
|
| PRK14608 |
PRK14608 |
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional |
30-280 |
4.85e-15 |
|
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
Pssm-ID: 237765 [Multi-domain] Cd Length: 290 Bit Score: 73.73 E-value: 4.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 30 ALLGDVVTVEAAETFSLNNLGRFADKLPSEPrENIVYQCWERFCQELGKQI-PVAMALEKNMPIGSGLGSSACSVVAALM 108
Cdd:PRK14608 39 ADVGDRLTLEPAEALSLTVSGPFAAGLGDGD-DNLVLRAARALRARVGPGLpPGAFHLEKNLPVAAGIGGGSADAAAALR 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 109 AMNEHCGKPLNDTRLLALMGELegrisGSihydNVAPCFLGGMQLMIEENDIISQqVPGFDEWLWVLAYPGIKVSTaear 188
Cdd:PRK14608 118 LLARLWGLALDDERLAALALSL-----GA----DVPVCLDSRPLIMRGIGEELTP-LPGLPSLPAVLVNPGVPVAT---- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 189 ailPAQYRRQDcIAHGRHLAGFIHACYSRQPELA--AKLMKDViaEPYRERLLPGFRQARQAV-AEIGAVASGISGSGPT 265
Cdd:PRK14608 184 ---PDVFRALG-LRDGPPLPGAPDPLASADALLAalAATRNDL--EPPALALAPVIGEVLAALrAQPGALLARMSGSGAT 257
|
250
....*....|....*
gi 431712160 266 LFALCDKPDTAQRVA 280
Cdd:PRK14608 258 CFALFADEAAAEAAA 272
|
|
| PRK03188 |
PRK03188 |
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional |
32-283 |
1.10e-14 |
|
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
Pssm-ID: 235110 [Multi-domain] Cd Length: 300 Bit Score: 73.00 E-value: 1.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 32 LGDVVTVEAAETFSLNNLGRFADKLPSEPReNIVYQCWERFCQELGKQIPVAMALEKNMPIGSGLGSSACSVVAALMAMN 111
Cdd:PRK03188 35 LYDEVTVTAADVLSVEVSGEGADQVPTDES-NLAWRAAELLAEHVGRAPDVHLHIDKGIPVAGGMAGGSADAAAALVACD 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 112 EHCGKPLNDTRLLALMGELegrisGSihydNVAPCFLGGMQLMIEENDIISQqVPGFDEWLWVLAYPGIKVSTAEARAIL 191
Cdd:PRK03188 114 ALWGLGLSRDELLELAAEL-----GS----DVPFALLGGTALGTGRGEQLAP-VLARGTFHWVLAFADGGLSTPAVFREL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 192 PAQYRRQDCIAHGRHlAGFIHACYSRQPE-LAAKLMKDViaEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFALC 270
Cdd:PRK03188 184 DRLREAGDPPRLGEP-DPLLAALRAGDPAqLAPLLGNDL--QAAALSLRPSLRRTLRAGEEAGALAGIVSGSGPTCAFLC 260
|
250
....*....|...
gi 431712160 271 DKPDTAQRVADWL 283
Cdd:PRK03188 261 ADADSAVDVAAAL 273
|
|
| GHMP_kinases_N |
pfam00288 |
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ... |
84-150 |
9.35e-13 |
|
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.
Pssm-ID: 395225 [Multi-domain] Cd Length: 64 Bit Score: 62.18 E-value: 9.35e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 431712160 84 MALEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDtrlLALMGELEgRISGSIHYDNVAPCFLGG 150
Cdd:pfam00288 2 IEIESNIPLGAGLGSSAALAVALLLALNELFGLPLAK---LALEAEEL-AGGGRGGGMDVAASLYGG 64
|
|
| ERG12 |
COG1577 |
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ... |
70-187 |
6.82e-10 |
|
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Pssm-ID: 441185 [Multi-domain] Cd Length: 277 Bit Score: 58.70 E-value: 6.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 70 ERFCQELGKQI-PVAMALEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRL--LALMGELE--GRISGsihYDNVA 144
Cdd:COG1577 69 EAALEYLGLPLkGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYGVELSKEELfkLALEAEKIvhGNPSG---LDTAA 145
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 431712160 145 pCFLGGMQLMieENDIISQQVPGFDEWLWVLAYPGIKVSTAEA 187
Cdd:COG1577 146 -STYGGPIYY--QRGDRAEPLELPKNLPLVVGDTGVPASTKEL 185
|
|
| mevalon_kin |
TIGR00549 |
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ... |
16-214 |
1.98e-09 |
|
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]
Pssm-ID: 273130 [Multi-domain] Cd Length: 273 Bit Score: 57.30 E-value: 1.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 16 GFDVLGAAVTpvdgaLLGDVVTVEAAETFSL-NNLGRFADKLPSEPRENIVY--QCWERFCQELgKQIPVAMALEKNMPI 92
Cdd:TIGR00549 16 GEPAIAAPIP-----LRTTVTVIESSDGSFIeSDLGRGSLDDAPDELDGLKYvlAEFLSRFSEL-NPPPLEITIESEIPP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 93 GSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELE----GRISGsihYDNvAPCFLGGMqLMIEENDIISQQVPGF 168
Cdd:TIGR00549 90 GRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEkiahGKPSG---IDT-ATSTSGGP-VYFEKGEGEFTKLISL 164
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 431712160 169 DEWLwVLAYPGIKVSTAEARAILpaqyrRQDCIAHGRHLAGFIHAC 214
Cdd:TIGR00549 165 DGYF-VIADTGVSGSTKEAVARV-----RQLLERFPELIDSIMDAI 204
|
|
| PRK14611 |
PRK14611 |
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; |
58-186 |
4.13e-09 |
|
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
Pssm-ID: 184767 [Multi-domain] Cd Length: 275 Bit Score: 56.30 E-value: 4.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 58 SEPRENIVYQCWERFCQELGKQIPVAMALEKNMPIGSGLG--SSACSVVaaLMAMNEHCGKPLNDTRLLalmgelegRIS 135
Cdd:PRK14611 57 IKEEENIVYKALRLFERYTGIDINYSIFIEKNIPVGAGLGggSSNAAVV--LKYLNELLGNPLSEEELF--------ELA 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 431712160 136 GSIHYDnvAPCFLGGMQLMIEEndiISQQVPGFDEWL---WVLAYPGIKVSTAE 186
Cdd:PRK14611 127 SSISAD--APFFLKGGFALGRG---IGDKLEFLEKPIsreITLVYPNIKSSTGR 175
|
|
| GHMP_kinases_C |
pfam08544 |
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ... |
210-287 |
1.25e-05 |
|
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.
Pssm-ID: 430063 [Multi-domain] Cd Length: 85 Bit Score: 42.84 E-value: 1.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 210 FIHACYSRQPELAAKLMK----DVIAEPYRERLLPGFRQARQAVAEIGAVA--SGiSGSGPTLFALCDKPDTAQRVADWL 283
Cdd:pfam08544 1 LLEALLRGDLEELGKLLTesaeSLEPLLVVGILPPELDELLEALLELGLGAklSG-SGGGPTVFALFKDEDDAEEVARAL 79
|
....
gi 431712160 284 GKNY 287
Cdd:pfam08544 80 REAG 83
|
|
| COG2605 |
COG2605 |
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ... |
70-131 |
1.01e-04 |
|
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];
Pssm-ID: 442017 [Multi-domain] Cd Length: 328 Bit Score: 43.24 E-value: 1.01e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 431712160 70 ERFCQELGKQIPVAMALEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELE 131
Cdd:COG2605 75 REALKLFGIGDGLEITTDSDAPAGSGLGSSSALTVALLNALHALLGLPLSPYDLARLAYEIE 136
|
|
| PRK03926 |
PRK03926 |
mevalonate kinase; Provisional |
49-137 |
2.13e-04 |
|
mevalonate kinase; Provisional
Pssm-ID: 179677 [Multi-domain] Cd Length: 302 Bit Score: 42.35 E-value: 2.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431712160 49 LGRFADKLPseprenIVYQCWERFCQELGKQiPVAMALEKNMPIGSGLGSSACSVVAALMAMNE--HCGKPLNDtrlLAL 126
Cdd:PRK03926 50 YGKTGEKHP------YVSAAIEKMREEADKD-GVTVSITSQIPVGSGLGSSAAVTVATIGALNRllGLGLSLEE---IAK 119
|
90
....*....|..
gi 431712160 127 MG-ELEGRISGS 137
Cdd:PRK03926 120 LGhKVELLVQGA 131
|
|
| PRK03817 |
PRK03817 |
galactokinase; Provisional |
81-128 |
6.21e-03 |
|
galactokinase; Provisional
Pssm-ID: 235163 [Multi-domain] Cd Length: 351 Bit Score: 37.67 E-value: 6.21e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 431712160 81 PVAMALEKNMPIGSGLGSSACSVVAALMAMNEHCGkpLNDTRL-LALMG 128
Cdd:PRK03817 86 GVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYN--LNLSKLeLALLA 132
|
|
| |
