|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
16-430 |
2.89e-80 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 252.97 E-value: 2.89e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 16 VLFFTVFIDMMGFSVIFPIFPEMLKTFLSKSGDPV-------LDKFTDFTKILTGDWPLFVaLFGGIVASLYSLLQFAFA 88
Cdd:cd17389 3 IVFLALLLDLLAFTIILPLFPSLLDYYGQNDDSGLyslqissVDWFRDAIGAPDERRYNSV-LFGGLIGSLFSLLQFLSS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 89 PIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAMADITNEKDRAKGMGLIGAGV 168
Cdd:cd17389 82 PITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 169 GLGFIAGPPTGGLFAkigpgfleLMFPNATFTVFPASALAAATIALFNLLMIVFWFRETFDPKNRALsetkkihpivgvf 248
Cdd:cd17389 162 SLGFIIGPMIGAYFA--------SFTRSLGEVFFSMPALFALVLALADLLFIFFFLPETLPSNLRRL------------- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 249 nsknkeviiySFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFTFVYIGIIIVLIQGGVFRKLSgKVKETRLVRAGTL 328
Cdd:cd17389 221 ----------GLVYFLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIK-PGKEKKAVLQGLI 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 329 SLLVGFSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGRGLAPFVFCLIYFNRGP 408
Cdd:cd17389 290 LLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAGS 369
|
410 420
....*....|....*....|..
gi 695135051 409 AISFLTSGLICLLFLVFIWKLK 430
Cdd:cd17389 370 EACYTIGALLFLLPLLLLARLK 391
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
17-428 |
3.01e-57 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 192.02 E-value: 3.01e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 17 LFFTVFIDMMGFSVIFPIFPEMLKTFLSKSGDPvldkftdftkiltgdwplfvaLFGGIVASLYSLLQFAFAPIWGKISD 96
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASG---------------------YYVGLLQSSYSLGQFLASPLWGRLSD 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 97 RVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAMADITNEKDRAKGMGLIGAGVGLGFIAGP 176
Cdd:cd17330 60 RYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGP 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 177 PTGGLFAKIGPGFLELMFpnatftvfpasalaAATIALFNLLMIVFWFRetfdpknralsetkkihPIVGVFnsknkevi 256
Cdd:cd17330 140 ALGGFLSTPYGYALPFLV--------------AAALALLNLVLVLFFLP-----------------PLRRLL-------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 257 iysFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFTFVYIGIIIVLIQGGVFRKLSGKVKETRLVRAGTLSLLVGFSL 336
Cdd:cd17330 181 ---LVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLL 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 337 LYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGRGLAPFVFCLIYFNRGPAISFLTSG 416
Cdd:cd17330 258 LPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAA 337
|
410
....*....|..
gi 695135051 417 LICLLFLVFIWK 428
Cdd:cd17330 338 GLLLIALFLLSL 349
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
16-404 |
6.48e-52 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 178.98 E-value: 6.48e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 16 VLFFTVFIDMMGFSVIFPIFPEMLKTFLSKSGDpvldkftdftkiltgdwplfVALFGGIVASLYSLLQFAFAPIWGKIS 95
Cdd:cd17388 3 FILVTVLLDAMGIGLIMPVLPTLLREFVGDSAD--------------------AATHYGVLLALYALMQFIFAPILGALS 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 96 DRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAMADITNEKDRAKGMGLIGAGVGLGFIAG 175
Cdd:cd17388 63 DRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAG 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 176 PPTGGLFAKIGpgflelmfPNATFTVfpasalaAATIALFNLLMIVFWFRETFDPKNRALSETKKIHPIVGVFNSKNKEV 255
Cdd:cd17388 143 PALGGLLGEIS--------PRAPFLV-------AAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPG 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 256 IIYSFLYFIFVFAFSGFEFSI-NFYLSQFLNYSPVAIGFTFVYIGIIIVLIQGGVFRKLSGKVKETRLVRAGTLSLLVGF 334
Cdd:cd17388 208 LLGLLAVFFLIQLIGQVPATTwVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGF 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 335 SLLYFVSNSYQLFISLTFLASGSaLLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGRGLAPFVFCLIYF 404
Cdd:cd17388 288 LLLAFATQGWMVFPILILLALGG-IAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFA 356
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-430 |
4.54e-42 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 152.73 E-value: 4.54e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 17 LFFTVFIDMMGFSVIFPIFPEMLKTFlsksgdpvldkftdftkiltGDWPLFValfgGIVASLYSLLQFAFAPIWGKISD 96
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESL--------------------GASVAQI----GLIVAAYALAQLLFSPPAGRLSD 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 97 RVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAM-ADITNEKDRAKGMGLIGAGVGLGFIAG 175
Cdd:cd17325 57 RFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALiADIAPPEERGRAMGIFSSAIGLGFLIG 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 176 PPTGGLFAkigpgflelmfpnaTFTVFPASALAAATIALFNLLMIVFWFRETFDPKNRALSETKKIHPIVGVFnSKNKEV 255
Cdd:cd17325 137 PLLGGLLA--------------DALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLL-LRDRRL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 256 IIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFTFVYIGIIIVLIQGgVFRKLSGKVKETRLVRAGTLSLLVGFS 335
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQP-PAGKLSDRIGRKPLILIGLLLSAVALL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 336 LLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGRGLAPFVFCLIYFNRGPAISFLTS 415
Cdd:cd17325 281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360
|
410
....*....|....*
gi 695135051 416 GLICLLFLVFIWKLK 430
Cdd:cd17325 361 AALLLLAAVLFLLLR 375
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
17-398 |
9.15e-35 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 132.35 E-value: 9.15e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 17 LFFTVFIDMMGFSVIFPIFPEMLKtflSKSGDPVLdkftdftkiltgdwplfvalfGGIVASLYSLLQFAFAPIWGKISD 96
Cdd:cd17390 1 LYLVGFLDLFGVSMILPLLSTHIR---SLGASPTV---------------------IGLIGSVYGALQLFSSPLVGSWSD 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 97 RVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAMADITNEKDRAKGMGLIGAGVGLGFIAGP 176
Cdd:cd17390 57 VVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGP 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 177 PTGGLFAKIGPGFLELMFpnATFTVFpasalaaatiaLFNLLMIVFWFREtfdpknralsetkkihpivgvfnsknkevi 256
Cdd:cd17390 137 VVGGHLAETDGGFYYVAL--LCSAIF-----------ILNAGLVWFLLSK------------------------------ 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 257 IYSFLYFIFVFAFSGFEFSINF--YLSQFLNYSPVAIGFTFVYIGIIIVLIQGGVFRKLS-GKVKETRLVRAGTLSLLVG 333
Cdd:cd17390 174 LWDLLLVRFLMGFSVLLFRSNFslYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKlYKNNEYLLLLHSFILLALS 253
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 695135051 334 FSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGRGLAPFV 398
Cdd:cd17390 254 LLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLL 318
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-395 |
4.33e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 122.00 E-value: 4.33e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 15 FVLFFTVFIDMMGFSVIFPIFPEMLKTFlsksgdpvldkftdftkiltgDWPLFVAlfgGIVASLYSLLQFAFAPIWGKI 94
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADL---------------------GASPAQA---GLVVTAYLLGAALGAPLAGRL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 95 SDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGM-MGGNISVASAAMADITNEKDRAKGMGLIGAGVGLGFI 173
Cdd:COG2814 69 ADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 174 AGPPTGGLFAkigpgflELMFPNATFTVFpasalaaATIALFNLLMIVFWFRETFDPKNRALSETKKIHPivgvfnsKNK 253
Cdd:COG2814 149 LGPLLGGLLA-------DLFGWRWVFLVN-------AVLALLALLLLLRLLPESRPAARARLRGSLRELL-------RRP 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 254 EVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFTFVYIGIIIVLIQgGVFRKLSGKVKETRLVRAGTLSLLVG 333
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALG 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695135051 334 FSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGRGLA 395
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
74-429 |
1.69e-26 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 109.62 E-value: 1.69e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAM-ADIT 152
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMiADVT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 153 NEKDRAKGMGLIGAGVGLGFIAGPPTGGLFAKIGPGFLELmfpnATFTVFpasalaaatiaLFNLLMIVFWFRETFdPKN 232
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFL----AAAVLF-----------LLAALVLLFLLPETR-PKR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 233 RALSETKKIHPIVGVFnsKNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFTFVYIGIIIVLIQgGVFRK 312
Cdd:cd17329 182 RAAEKTEILRGYKIVL--RDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQ-FPVAR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 313 LSGKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGR 392
Cdd:cd17329 259 LVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGR 338
|
330 340 350
....*....|....*....|....*....|....*..
gi 695135051 393 GLAPFVFCLIYFNRGPAISFLTSGLICLLFLVFIWKL 429
Cdd:cd17329 339 AIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
78-427 |
1.44e-25 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 107.30 E-value: 1.44e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 78 SLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGnISVASAAMADITNEKDR 157
Cdd:cd17331 42 TTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHA-MQAAQMVVTDLTDPGER 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 158 AKGMGLIGAGVGLGFIAGPPTGGLFAKIGPGFLELMFPNAtftvfpasalaaatIALFNLLMIVFWFRETFDPKNRALSE 237
Cdd:cd17331 121 AAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAV--------------GSLLSIVLVILLIPSNTKSKREKEAK 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 238 TKKIHPIVGVFNSKNKEVIIYSFLYFIFVFAFSGFEFSI-----NFYLSQFLNYSPVAIGFTFVYIGIIIVLIQGGVFRK 312
Cdd:cd17331 187 ESASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMfqsmfSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGP 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 313 LSGKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGR 392
Cdd:cd17331 267 LTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVR 346
|
330 340 350
....*....|....*....|....*....|....*
gi 695135051 393 GLAPFVFCLIYFNRGPAISFLTSGLICLLFLVFIW 427
Cdd:cd17331 347 TVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLL 381
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
15-429 |
1.74e-24 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 104.19 E-value: 1.74e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 15 FVLFFTVFIDMMGFSVIFPIFPEMLKTFlsksgdpvldkftdftkiltGDWPLFVALfggiVASLYSLLQFAFAPIWGKI 94
Cdd:cd17474 2 YAVFFATLLAVLGVSIVDPILPAIAEAL--------------------GASPAQVGL----LITAFTLPAAVLMPVAGVL 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 95 SDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAMA-DITNEKDRAKGMGLIGAGVGLGFI 173
Cdd:cd17474 58 ADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIgDLFEGGERAKAMGLYEAALGLGIA 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 174 AGPPTGGLFAKIGpGFLELMFPNATFTVFpasalaaatialfnLLMIVFWFRETfDPKNRALSETKKIHPIVGVfnsKNK 253
Cdd:cd17474 138 VGPLLGGLLAAIS-WRYPFFLLAALIPVA--------------FLAILFLLPEP-KEKAKSSSATKLRDLKKAL---RGR 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 254 EVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFTFVYIGIIIVLIQGGVFRKLSGKVKETRLVRAGTLSLLVG 333
Cdd:cd17474 199 GLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALS 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 334 FSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGRGLAPFVFCLIYFNRGPAISFL 413
Cdd:cd17474 279 LLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFL 358
|
410
....*....|....*.
gi 695135051 414 TSGLICLLFLVFIWKL 429
Cdd:cd17474 359 VGAAIALAAAVLLALL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-396 |
7.34e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 99.03 E-value: 7.34e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 17 LFFTVFIDMMGFSVIFPIFPEMLKTFLSKSGDPVldkftdftkiltgdwplfvalfgGIVASLYSLLQFAFAPIWGKISD 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEI-----------------------GLLLTLFSLGYALAQPLAGRLSD 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 97 RVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAM-ADITNEKDRAKGMGLIGAGVGLGFIAG 175
Cdd:pfam07690 58 RFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALiADWFPPEERGRALGLVSAGFGLGAALG 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 176 PPTGGLFAKIGpGFLELMFPNATFTVFpasalaaatialfnLLMIVFWFRETFDPKNRALSETKKIHPIVGVFNSKNKEV 255
Cdd:pfam07690 138 PLLGGLLASLF-GWRAAFLILAILSLL--------------AAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPV 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 256 IIYSFLYFIFVFAFSGFEFSINFYLSQFlNYSPVAIGFTFVYIGIIIVLIQ--GGVFRKLSGKVKETRLVRAGTLSLLVG 333
Cdd:pfam07690 203 LWLLLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRllLGRLSDRLGRRRRLLLALLLLILAALG 281
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695135051 334 FSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGRGLAP 396
Cdd:pfam07690 282 LLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
15-427 |
2.27e-20 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 92.25 E-value: 2.27e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 15 FVLFFTVFIDMMGFSVIFPIFPEMLKTFLSKSgdpvldkftdftkiltgdwplfvALFGGIVASLYSLLQFAFAPIWGKI 94
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQHFVPNS-----------------------ELLVPLLLTLPALFIALFAPLAGWL 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 95 SDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGM-MGGNISVASAAMADITNEKDRAKGMGLIGAGVGLGFI 173
Cdd:cd17473 59 ADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIgVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGV 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 174 AGPPTGGLFAKIGPgflelmfpNATFTVFpasalaaatiaLFNLLMIVFWFRETFDPKNRALSETKKIHPIVGVFnsKNK 253
Cdd:cd17473 139 VFLLLGGALAEIGW--------RAPFLVY-----------LLALPVLILVLLFLPEPARKSKSAASPGAATAAAL--PWK 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 254 EVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFTFVYIGIIIVLIqGGVFRKLSGKVKETRLVRAGTLSLLVG 333
Cdd:cd17473 198 RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIG-ALLFGRLKRRLGKRRLLAIGFALMALG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 334 FSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGRGLAPFVF-CLIYFNRGPAISF 412
Cdd:cd17473 277 FLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLgPLVNLTGGLSGAF 356
|
410
....*....|....*
gi 695135051 413 LTSGLICLLFLVFIW 427
Cdd:cd17473 357 LILGVLALVLAIVLL 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
74-427 |
5.83e-20 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 90.73 E-value: 5.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGM-MGGNISVASAAMADIT 152
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIgWGAFTTAAATLVADII 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 153 NEKDRAKGMGLIGAGVGLGFIAGPPTGGLFAKigpgflelmfpnatFTVFPASALAAATIALFNLLMIVFWFRETFDPKN 232
Cdd:cd17489 114 PPSRRGEGIGYYGLATTLAMALGPALGLFLYQ--------------HLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 233 RALSETKKIHPIVgvfnskNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFLnysPVAIGFTFVyIGIIIVLIQGGVFRK 312
Cdd:cd17489 180 EAEAGTRAFRRLV------EKKVLPPALILFLASIAYGAISTFLPLYAAERG---ISNAGLFFT-VYAIALLLSRPFSGK 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 313 LSGKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGR 392
Cdd:cd17489 250 LSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGI 329
|
330 340 350
....*....|....*....|....*....|....*
gi 695135051 393 GLAPFVFCLIYFNRGPAISFLTSGLICLLFLVFIW 427
Cdd:cd17489 330 GLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
15-427 |
2.45e-16 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 79.95 E-value: 2.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 15 FVLFFTVFIDMMGFSVIFP-IFPEMLKtfLSKSGDpvldkftdftkiltgdwplfvALFGGIVASLYSLLQFAFAPIWGK 93
Cdd:cd17326 2 YVMYLTMFLSSLQFSIVLTsIWPYLQK--IDPTAT---------------------ASFFGWVVAAYSLGQLVFSPVFGY 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 94 ISDRVG-RKPVLVLTSFGSFFGYTIWLFSGSFSLFV-----FSRVITGMMGGNISVASAAMADITNEKDRAKGMGLIGAG 167
Cdd:cd17326 59 WSNKTSsVKEPLIVSILIAIVGNILYALAEYFPSNRkyvmlVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAA 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 168 VGLGFIAGPPTGGLFAKIGPGFLELMfPNATFTVFPASALAAATIALFNLLMIVFWFREtfdpknralsetkkihpivgv 247
Cdd:cd17326 139 QALGFIVGPALQAAFTPIGYPGYVIG-IKLRFNMYTAPAWLMAILGIINIILILFFFKE--------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 248 fnsknkevIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSP---VAIGFTFVYIGIIIVLIQGGVFRKLSGKVKETRLVR 324
Cdd:cd17326 197 --------VVCIFLFFVVLFIFANLETIGTPLTMDMYGWTReeaVLYNGIILAVSGVLSVLVFLLFKFLSLGLIDERKIL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 325 AGTLSLLVGFSLLYFVSNsyqlFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGRGLAPFVFCLIYF 404
Cdd:cd17326 269 LGGLILFFLGFVVTLPWG----ITGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYT 344
|
410 420
....*....|....*....|...
gi 695135051 405 NRGPAISFLTsgLICLLFLVFIW 427
Cdd:cd17326 345 HFGPRWTWII--TLGLLLLAIIL 365
|
|
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
55-404 |
1.05e-15 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 78.62 E-value: 1.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 55 TDFTKILTGDWPLFVALFGGIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSrvIT 134
Cdd:cd17387 20 TPMITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWWYFAMIS--VS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 135 GMMGGNISVASAAMADITNEKDRAKGMGLIGAGVGLGFIAGPPTGG-LFAKIGPGFLELMfpnATFTvfpasalaaatiA 213
Cdd:cd17387 98 GIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAyLSESYGDNLVVLV---ATIV------------A 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 214 LFNLLMIVFWFRETFDPKNRALSETKKI-HPIVGVFNS-----KNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYS 287
Cdd:cd17387 163 LLDICFILLAVPESLPEKMRPASWGAPIsWEQADPFASlrkvgKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMGFE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 288 PVAIGFTFVYIGIIIVLIQGGVFRKLSGKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTfLASGSALLHPSLSTL 367
Cdd:cd17387 243 YEEVAAFIAVVGILSITAQTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGA-VAAMSSITFPAISAL 321
|
330 340 350
....*....|....*....|....*....|....*..
gi 695135051 368 VSLVSSREEQGTNLGIFRSLASLGRGLAPFVFCLIYF 404
Cdd:cd17387 322 VSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFY 358
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
18-427 |
1.62e-15 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 77.69 E-value: 1.62e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 18 FFTVFIDMMGFSVIFPIFPEMLKTFLSKSGDpvldkftdftkiltgdwplFVALFGGIVASLYSLLQFAFAPIWGKISDR 97
Cdd:cd17391 2 WLGNFFTGIGFSLIAPFLPLYIEQLGVTSGG-------------------LVELWSGLAFSSTFLVSAIFSPIWGRLADR 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 98 VGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAMADITNEKDRAKGMGLIGAGVGLGFIAGPP 177
Cdd:cd17391 63 YGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 178 TGGLFAkigpgflELMFPNATFTVfpasalaAATIALFNLLMIVFWFRETFDPKNRALSETKKihpivGVFNS-KNKEVI 256
Cdd:cd17391 143 LGGFLA-------DLFGIRNVFFI-------TGGLLFLAFLLTLFFVKEDFKPVEKKKMVSTK-----EVWNSvPNPSLL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 257 IYSFL-YFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFTFVYIGIIIV--LIQGGVFRKLSGKVKETRLVRAGTLSLLVG 333
Cdd:cd17391 204 ISLFVtTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSATGVssLLSAPRLGKLGDRIGHHRILLGALLASALL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 334 FSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGRGLAPFVFCLIYFNRGPAISFL 413
Cdd:cd17391 284 YIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFV 363
|
410
....*....|....
gi 695135051 414 TSGLICLLFLVFIW 427
Cdd:cd17391 364 VTALLVLLNAIWSF 377
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
74-427 |
2.13e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 77.20 E-value: 2.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGM-MGGNISVASAAMADIT 152
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLaHGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 153 NEKDRAKGMGLIGAGVGLGFIAGPPTGGLFAKIGpGFLELMFPNATFTVfpasalaaatialfnLLMIVFWFREtfdPKN 232
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL-GWRAAFLAIAVLAL---------------LAALLLWRLL---PSL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 233 RALSETKKIHPIVGVFNSKNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFTF--VYIGIIIVLIQGGvf 310
Cdd:cd17324 178 PPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLllFGVAGVVGSPLAG-- 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 311 rKLSGKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSrEEQGTNLGIFRSLASL 390
Cdd:cd17324 256 -RLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNL 333
|
330 340 350
....*....|....*....|....*....|....*..
gi 695135051 391 GRGLAPFVFCLIYFNRGPAISFLTSGLICLLFLVFIW 427
Cdd:cd17324 334 GGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
74-432 |
6.02e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 76.07 E-value: 6.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGM-MGGNISVASAAMADIT 152
Cdd:COG2223 43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIgGGGSFAVGIALVSKWF 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 153 NEKDRAKGMGLIGAGVGLGFIAGPPtgglfakIGPGFLELMFPNATFTVFpasalaaatIALFNLLMIVFWFRETFDPKN 232
Cdd:COG2223 123 PPDRRGLALGLAAGGGNLGAAVAAF-------LAPLLIAAFGWRNAFLIL---------GILLLVVAVLAWLFLRDPPAG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 233 RALSETKKIHPIVGVFnsKNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFtFVYIGIIIVLIQGGVFRK 312
Cdd:COG2223 187 AAAAAKASLRDQLEAL--RDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGL-LAALFALLGALGRPLGGW 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 313 LSGKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTF-LASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLG 391
Cdd:COG2223 264 LSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLlLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLG 343
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 695135051 392 RGLAPFVFCLIYFNRG-PAISFLTSGLICLLFLVFIWKLKQP 432
Cdd:COG2223 344 GFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRR 385
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
76-430 |
1.41e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 74.90 E-value: 1.41e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 76 VASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNI-SVASAAMADITNE 154
Cdd:cd17321 36 VVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAImPASLALIAATFPG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 155 KDRAKGMGLIGAGVGLGFIAGPPTGGLfakigpgFLELMFPNATFtvfpasalaaatiaLFNLLMIvfwfretfdpknra 234
Cdd:cd17321 116 ERRGRALGLWGAVVGIGAALGPLLGGL-------LLELFGWRWIF--------------LINVPIG-------------- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 235 lsetkkihpIVGVFNSKNkeVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFTFVyIGIIIVLIQGGVFRKLS 314
Cdd:cd17321 161 ---------LVALLLART--FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALL-PLALAMLVAAPLAGRLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 315 GKVKETRLVRAGTLSLLVGFSLLYFVSNS---YQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLG 391
Cdd:cd17321 229 DRFGPRLVLVAGLLLTAVGLLLLALLGADssvWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLG 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695135051 392 RGLAPFVFCLIY-----------------------FNRGPAISFLTSGLICLLFLVFIWKLK 430
Cdd:cd17321 309 GALGVALLGALLtaglsanlgdsgvaallsaaaaaFAAGFHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
74-430 |
2.14e-14 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 74.17 E-value: 2.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMmGGNISVASAAMADITN 153
Cdd:cd17472 35 GLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS-GAISSVVMALLADLTR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 154 EKDRAKGMGLIGAGVG----LGFIAGPptgGLFAKIGpgflelmfpnatftvFPASALAAATIALFNLLMIVFWFRETFD 229
Cdd:cd17472 114 EENRTKAMALIGASIGiafaISMVLGP---LLAAHLG---------------VSGLFLITAILSLVSLLILLFFVPDPPK 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 230 PKNRALSETKKIHPIVgvfnsKNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSP-VAIGFTFVYIGIIIVLIQGG 308
Cdd:cd17472 176 IVQISEKEKKKLKKLL-----KNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGqLWKVYLPAILIGFILMVPFV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 309 VFRKLSGKVKetRLVRAGTLSLLVGFSLLYFVSNS-YQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSL 387
Cdd:cd17472 251 IYAEKKGKMK--QVFVSSILLIAVGFLLLLFAATSlWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTS 328
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 695135051 388 ASLGRGLAPFVFCLIYFNRGPAISFLTSGLICLLFLVFIWKLK 430
Cdd:cd17472 329 QFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSFLLP 371
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
74-181 |
2.50e-14 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 69.60 E-value: 2.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAM-ADIT 152
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALiADIY 80
|
90 100
....*....|....*....|....*....
gi 695135051 153 NEKDRAKGMGLIGAGVGLGFIAGPPTGGL 181
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGV 109
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
70-429 |
4.46e-14 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 73.42 E-value: 4.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 70 ALFGGIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGS---FFGYTIWLFSGSFS---LFVFSRVITGMMGGNISV 143
Cdd:cd06173 33 ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRallAAVLALLALLGSLSlwlLLVLAFLLGIASAFFGPA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 144 ASAAMADITNEKDRAKGMGLIGAGVGLGFIAGPPTGGLFAKIGPGFLELMFPNATFTVfpasalaaatiALFNLLMIVFW 223
Cdd:cd06173 113 RQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLL-----------SALLLLFIRRP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 224 FRETFDPKNRALSETKKIhpiVGVFNSKNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFTFVYIGIIIV 303
Cdd:cd06173 182 PPAAPGESSSLLLRDLRE---GLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGAL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 304 LIqGGVFRKLSGKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGI 383
Cdd:cd06173 259 LG-ALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSV 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 695135051 384 FRSLASLGRGLAPFVFCLIYFNRGPAISFLTSGLICLLFLVFIWKL 429
Cdd:cd06173 338 YNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
74-427 |
6.29e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 72.84 E-value: 6.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAM-ADIT 152
Cdd:cd06174 34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALiADLF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 153 NEKDRAKGMGLIGAGVGLGFIAGPPTGGLFAKIGPGFLELMFpnatftvfpasALAAATIALFNLLMIVFWFRETFDPKN 232
Cdd:cd06174 114 PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVF-----------LIAAALALLAAILLLLVVPDPPESARA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 233 RALSETKKIHPIVGVFNSKNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFTFVYIGIIIVLIQGGVFRK 312
Cdd:cd06174 183 KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 313 LSGKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGR 392
Cdd:cd06174 263 SDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGG 342
|
330 340 350
....*....|....*....|....*....|....*.
gi 695135051 393 GLAPFVFC-LIYFNRGPAISFLTSGLICLLFLVFIW 427
Cdd:cd06174 343 AIGPLLAGfLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
74-432 |
6.88e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 72.60 E-value: 6.88e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGM-MGGNISVASAAMADIT 152
Cdd:COG2271 48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLgEAGFFPAALKLIAEWF 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 153 NEKDRAKGMGLIGAGVGLGFIAGPPtgglfakIGPGFLELMFPNATFTVFpasalaaatiALFNLLMIVFWFretfdpkn 232
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPP-------LLGWLLAAFGWRAAFLIL----------GLPGLLLALLRF-------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 233 ralsetkkihpivgvfnsknkevIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGF--TFVYIGIIIVLIQGGvf 310
Cdd:COG2271 183 -----------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLllSLPFLAGIVGSLLGG-- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 311 rKLSGKVKETR--LVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLA 388
Cdd:COG2271 238 -WLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFG 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 695135051 389 SLGRGLAPFVFCLIYFNRGPAISFLTSGLICLLFLVFIWKLKQP 432
Cdd:COG2271 317 FLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
90-426 |
3.65e-12 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 67.60 E-value: 3.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 90 IWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAMA-DITNEKDRAKGMGLIGAGV 168
Cdd:cd17320 53 LYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVrDLYSGAELAKIFSLLMMIL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 169 GLGFIAGPPTGGLFAKIGPgflelmfPNATFTVFpasalaaATIALFNLLMIVFWFRETFDPKNRALSETKKIHPIVGVF 248
Cdd:cd17320 133 AIAPALAPLLGGLLLLFFG-------WRAIFVFL-------ALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 249 nsKNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFTFvyIGIIIVLIQGGVF-RKLSGKVKETRLVRAGT 327
Cdd:cd17320 199 --KNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLF--ALNAIALILGSLLnGRLVRRFGPRRLLRLGL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 328 LSLLVGFSLLYFVS-----NSYQLFISLTFLASGSALLHPSLSTLVsLVSSREEQGTNLGIFRSLASLGRGLAPFVFCLI 402
Cdd:cd17320 275 LLLLAAALVLLLAAllgglSLWPLVAPLFLIFFGFGLIFPNATSLA-LEPFPHVAGTASALLGFLQFLIGALAGALVGLL 353
|
330 340
....*....|....*....|....*.
gi 695135051 403 YFNRGPAIS--FLTSGLICLLFLVFI 426
Cdd:cd17320 354 PNGTALPMGllILVLGLLALLLLILL 379
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
74-435 |
4.33e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 64.10 E-value: 4.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAMADITN 153
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 154 EKDRAKGMGLIGAGVGLGFIAGPPTGGLFAKIGPGfLELMFPNATFTVFPAsalaaatialfnLLMIVFWFRETFDPKNR 233
Cdd:COG0738 126 PETAASRLNLLHAFFSLGALLGPLLGGLLILLGLS-LSWHLPYLILAVLLL------------LLALLFLRSKLPEIEEE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 234 ALSETKKIHPIVGVFnsKNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSP--VAIGFTFVYIGIIIVLIQGGVFR 311
Cdd:COG0738 193 EEEAAGSAASLKSLL--KNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEatAALGLSLFWGGMTIGRFLGGFLL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 312 KlsgKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSALLHPslsTLVSLVSSR--EEQGTNLGIFRSLAS 389
Cdd:COG0738 271 K---RFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFP---TIFSLALDGlgKRTAAAVSAVLIMGI 344
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 695135051 390 LGRGLAPFVFCLIYFNRGPAISFLTSGLICLLFLVFIWKLKQPNHS 435
Cdd:COG0738 345 VGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
76-183 |
7.82e-11 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 62.97 E-value: 7.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 76 VASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNI-SVASAAMADITNE 154
Cdd:cd17502 35 VGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLmSLAFIIIADLVPP 114
|
90 100
....*....|....*....|....*....
gi 695135051 155 KDRAKGMGLIGAGVGLGFIAGPPTGGLFA 183
Cdd:cd17502 115 RERGKYQGYIGAVFGIASVAGPLIGGAFT 143
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
74-183 |
5.37e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 60.21 E-value: 5.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGM-MGGNISVASAAMADIT 152
Cdd:COG0477 52 GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIgAGGLMPGALALIAELF 131
|
90 100 110
....*....|....*....|....*....|.
gi 695135051 153 NEKDRAKGMGLIGAGVGLGFIAGPPTGGLFA 183
Cdd:COG0477 132 PARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
74-427 |
1.74e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 59.12 E-value: 1.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMM-GGNISVASAAMADIT 152
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAeAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 153 NEKDRAKGMGLIGAGVGLGFIAGPPTGGLfakigpgFLELMFPNATFTVFpasalaaatiALFNLLMIVFWFRetfdpkn 232
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGW-------LLLLFGWRWAFIIE----------GLLGLLLAVLWWF------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 233 ralsetkkihpivgvfnsKNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGF--TFVYIGIIIVLIQGGVF 310
Cdd:cd17319 177 ------------------YLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLlaAIPFLAGAIGMILGGRL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 311 RKLSGKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASL 390
Cdd:cd17319 239 SDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNL 318
|
330 340 350
....*....|....*....|....*....|....*...
gi 695135051 391 GRGLAPFVF-CLIYFNRGPAISFLTSGLICLLFLVFIW 427
Cdd:cd17319 319 GGFVAPLLIgYLVDATGSYTAAFLFLAAVALLAALLVL 356
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
10-183 |
2.18e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 58.74 E-value: 2.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 10 MNKTSFVLFFTVFIDMMGFSVIFPIFPEMLKTFLSksgdpvldkftdftkiltgdwplFVALFGGIVASLYSLLQFAFAP 89
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGG-----------------------LSPAQIGLLFGAQGLASALSQP 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 90 IWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAA-MADITNEKDRAKGMGLIGAGV 168
Cdd:cd17325 254 PAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLAlLADIVPPEGRGTAMGLFNTAF 333
|
170
....*....|....*
gi 695135051 169 GLGFIAGPPTGGLFA 183
Cdd:cd17325 334 SLGMVLGPLLGGFLY 348
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
88-426 |
5.46e-09 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 57.67 E-value: 5.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 88 APIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFS------LFVFSRVITGMMGGNISVASAAMA---DITNEKDRA 158
Cdd:cd17386 47 SLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVYFTtvpsvwWFYLSAIPLALFGGFTAFLSASFAyisDISSEKKRT 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 159 KGMGLIGAGVGLG-FIAGPPTGGLFAKIgpGFLELMFPNATFtvfpasalaaatiALFNLLMIVFWFretfdpknralse 237
Cdd:cd17386 127 YRMAILEVALGLGgFLGSLLSGHLFKAL--GYAWSFSISAAL-------------LLIALLYILFFL------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 238 tkkihpivgvfnsknKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGF--TFVYIGIIIVLIQGGVFRKLSG 315
Cdd:cd17386 179 ---------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYfsTLGSLIYLTGMLGGVLLLRCLL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 316 KVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSaLLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGRGLA 395
Cdd:cd17386 244 KMSDSTLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNG-IVGPMIRSILSKLVPKSEQGKIFSLLSVLESLSPLVA 322
|
330 340 350
....*....|....*....|....*....|....
gi 695135051 396 PFVFCLIY---FNRGPAISFLTSGliCLLFLVFI 426
Cdd:cd17386 323 SPIYNNIYkatLTTFPGFFFLLSA--GLLLIPVI 354
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
66-427 |
8.38e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 57.17 E-value: 8.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 66 PLFVALFG------GIVASLYSLLQFAFAPIWGKISDRVG-RKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVItGMMG 138
Cdd:cd17370 23 PLFLVVLGasaaavGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRIL-ERLG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 139 GNISVAS--AAMADITNEKDRAKGMGLIGAGVGLGFIAGPPTGGLFAKIGPGFLELMFpnaTFTVFPAsalaaatiaLFN 216
Cdd:cd17370 102 KGIRTPPrdALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNYRTIF---LLAAIPA---------LLA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 217 LLmIVFWFRETFDPKNRALSETKKIHpivgvFNSKNKEVIIYSFLYFIFVFAFSGFEFSInfYLSQFLNYSPVAIGFTFV 296
Cdd:cd17370 170 LL-ILLFVVKEYPRPPKLRKKSKKTS-----LKKLPKAFWLYLLAVALFALGNFSFAFLI--LRAQELGLSAALIPLLYA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 297 YIGIIIVLIqGGVFRKLSGKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREE 376
Cdd:cd17370 242 LFNLVYALA-AYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAEL 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 695135051 377 QGTNLGIFRSLASLGRGLAPFVFCLIYFNRGPAISFLTSGLICLLFLVFIW 427
Cdd:cd17370 321 RGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
71-427 |
3.20e-08 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 55.31 E-value: 3.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 71 LFGGIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAMAD 150
Cdd:PRK09874 54 MWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIAT 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 151 ITNEKDRAKGMGLIGAGVGLGFIAGPPTGGLFAKiGPGFLELMFPNATftvfpasalaaatIALFNLLMIVFWFRETFDP 230
Cdd:PRK09874 134 QVPRNKSGWALGTLSTGGVSGALLGPLAGGLLAD-SYGLRPVFFITAS-------------VLFLCFLVTLFCIRENFQP 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 231 knraLSETKKIHPIVGVFNSKNKEVIIYSFLYFIFVFAFSGfefSINFYLSQFL-----NYSPVA-IGFTFVYIGIIIVL 304
Cdd:PRK09874 200 ----VSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATG---SIAPILTLYVrelagNVSNIAfISGMIASVPGVAAL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 305 IQGGVFRKLSGKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIF 384
Cdd:PRK09874 273 LSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYN 352
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 695135051 385 RSLASLGRGLAPFVFCLIYFNRGPAISFLTSGLICLLFLVFIW 427
Cdd:PRK09874 353 QSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSW 395
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
86-396 |
3.79e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 54.89 E-value: 3.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 86 AFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAMADITNEKDRAKGMGLIG 165
Cdd:cd17504 46 VSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 166 AGVGLGFIAGPPTGGLFAKIgpgfleLMFPNATFTVFPASALAAATIALFNLLMIvfwfretfdpknralsetkkihpiv 245
Cdd:cd17504 126 ATFGIGAGIGLPLGGWIVQH------LGWRWIFWTAAPVAVLLAALVPLIDLRLL------------------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 246 gvfnsKNKEVIIYSFLYFIFVFAFsgfeFSINFYLSQFLNY-SPVAIGFTFVYIGI------IIVLIQGGVFRKLSGKVK 318
Cdd:cd17504 175 -----RRRNVLLANITALLAGFGM----FMVFQLLPQLLQLpTPTGFGLGITEAGLlllpgaLVMLIAGPLAGRLIARVG 245
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695135051 319 ETRLVRAGTLSLLVGF-SLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGRGLAP 396
Cdd:cd17504 246 PRRVLLIGLVISAVGLlLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGP 324
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
259-427 |
2.40e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.42 E-value: 2.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 259 SFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIG--FTFVYIGIIIVLIQGGvfrKLSGKVKETRLVRAGTLSLLVGFSL 336
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGllLTLFSLGYALAQPLAG---RLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 337 LYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGRGLAPFVFCLIYFNRGPAISFLTSG 416
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170
....*....|.
gi 695135051 417 LICLLFLVFIW 427
Cdd:pfam07690 159 ILSLLAAVLLL 169
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
76-188 |
4.89e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 51.86 E-value: 4.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 76 VASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAMADITNEK 155
Cdd:cd06179 37 ISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNK 116
|
90 100 110
....*....|....*....|....*....|...
gi 695135051 156 DRAKGMGLIGAGVGLGFIAGPPTGGLFAKIGPG 188
Cdd:cd06179 117 YRGLVQGVVNLVASPGSALGPLIAGALVEANAA 149
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
15-181 |
5.60e-07 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 51.42 E-value: 5.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 15 FVLFFTVFIDMMGFSVIFPIFPEmlktFLSKSGdPVldkftdftkiltgdwplfvalfgGIVASLYSLLQFAFAPIWGKI 94
Cdd:cd17384 3 VIVYVALLLDNMLLTVVVPIIPD----YLNENV-RV-----------------------GLLFASKALVQLITNPIVGPL 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 95 SDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAM-ADI-TNEKDRAKGMGLIGAGVGLGF 172
Cdd:cd17384 55 TNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMlASLyPDDKERGKAMGIALGGLALGV 134
|
....*....
gi 695135051 173 IAGPPTGGL 181
Cdd:cd17384 135 LVGPPFGGV 143
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
75-304 |
6.26e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 51.04 E-value: 6.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 75 IVASLYsLLQFAFAP-IWGKISDRVGRKPVLVLTSFGsFFGYTIWL-FSGSFSLFVFSRVITGMMGGN-ISVASAAMADI 151
Cdd:cd17323 38 LGVSLF-VLGFGLGPlIWAPLSELYGRRPVYLVSLFI-FVIFQIGCaLAPNIAMLIILRFLQGFFGSSpLAIGAGTIADL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 152 TNEKDRAKGMGLIGAGVGLGFIAGPPTGGLFAKigpgflelmfpnatFTVFPASALAAATIALFNLLMIVFWFRETFdpk 231
Cdd:cd17323 116 FTPEERGKAMGVYSLGPLLGPALGPIIGGFITQ--------------SLGWRWIFWFLAIISGFCLILIFLFLPIVL--- 178
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695135051 232 nralsetkkihpIVGVFNSknkevIIYSFLYFIFVfafsgfefSINFYLSQFLNYSPVAIGFTFVYIGIIIVL 304
Cdd:cd17323 179 ------------LLGLYVG-----LVYAILYLFLT--------AFPYVFGEVYGFSPGEVGLMYLPIGIGALI 226
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
74-395 |
7.10e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.06 E-value: 7.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVG-----RKPVLVLTSFGSFFGYTI------WLFSGSFSLFVFSRVITGMMGGNIS 142
Cdd:COG2211 49 GLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLlftapdLSPTGKLIYALVTYLLLGLAYTLVN 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 143 VA-SAAMADIT-NEKDRAKGMGLIGAGVGLGFIAGPptgglfakIGPGFLELMFPNATFTVFPASALAAATIALFNLLMI 220
Cdd:COG2211 129 IPySALGAELTpDYEERTRLSSWRFAFAGLGGLLAS--------VLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLT 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 221 VFWFRETFDPKNRALSETKKIHPIVgvfnsKNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFTFVyIGI 300
Cdd:COG2211 201 FFGTKERPVPEEEKVSLKESLKALL-----KNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLA-LYF 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 301 IIVLIQGGVFRKLSGKVKETRLVRAGTLSLLVGFSLLYFV--SNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQG 378
Cdd:COG2211 275 LAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWK 354
|
330 340
....*....|....*....|
gi 695135051 379 TNL---GIFRSLASLGRGLA 395
Cdd:COG2211 355 TGRrreGLYFGIFTFAIKLG 374
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
74-425 |
8.10e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 50.68 E-value: 8.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVG-RKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAMADIT 152
Cdd:cd17490 34 GIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASYF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 153 NEKDRAKGMGLIGAGVGLGFIAGPPTGGLFA-KIGPGFLELMFPNATFTVFPasalaaatialfnllmIVFWFRETFDPK 231
Cdd:cd17490 114 PPDEAAKAMGLINLVNNLGQLIAFLIGGLIAeHFGMRAPFLLAALAGVLGFI----------------LSLFIKEERREK 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 232 NRALSETKKIHPIVgvfnsKNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIG---FTFVYIGIIIVLIQGG 308
Cdd:cd17490 178 KPVLTELKELLSVL-----KDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGllsIIYLLPNALASLLSGT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 309 VFRKLSGKVKeTRLVRAGTLSLLVGfsLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLA 388
Cdd:cd17490 253 LFYKKLGERN-TIIIGFLLLGAYCF--LIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIY 329
|
330 340 350
....*....|....*....|....*....|....*..
gi 695135051 389 SLGRGLAPFVFCLIYFNRGPAISFLTSGLICLLFLVF 425
Cdd:cd17490 330 ALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAIL 366
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
88-173 |
2.81e-06 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 49.63 E-value: 2.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 88 APIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAA-MADITNEKDRAKGMGLIGA 166
Cdd:TIGR00898 144 SFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVlNTEFLPKKQRAIVGTLIQV 223
|
....*..
gi 695135051 167 GVGLGFI 173
Cdd:TIGR00898 224 FFSLGLV 230
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
6-182 |
3.43e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 49.11 E-value: 3.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 6 LRAVMNKTSFVLFFTVFIDMMGFSVIFPIFPEMLKTFLSksgdpvldkftdftkiltgdwplFVALFGGIVASLYSLLQF 85
Cdd:COG2223 199 LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFG-----------------------LSAATAGLLAALFALLGA 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 86 AFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLF-SGSFSLFVFSRVITGM-MGGNISVASAAMADITNEKDRAKGMGL 163
Cdd:COG2223 256 LGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALaLGSLWLFLVLFLLLGLaLGGGNGAVFALVPDIFPTKNAGAVYGL 335
|
170
....*....|....*....
gi 695135051 164 IGAGVGLGFIAGPPTGGLF 182
Cdd:COG2223 336 VGAAGGLGGFLGPLLFGAL 354
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
47-293 |
3.80e-06 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 49.04 E-value: 3.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 47 GDPVLDKFTDFTKILTGDWPLFVALfGGIVASLYSLLQFafapiwGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSL 126
Cdd:cd17449 48 ASTSADPLQQEVETLTAHWNLYINL-GGFLVGLFSVTLL------GPWSDSVGRRPVLILPSLGLALQAAVYLLVMYLQL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 127 ----FVFSRVITGMMGG-NISVAS--AAMADITNEKDRAKGMGLIGAGVGLGFIAGPPTGGLFAK----IGPGFLELmfp 195
Cdd:cd17449 121 hvayFLIGRILSGLLGDfNGILAGcfAYVADVSDRRSRTFRVAVLEACLGLAGMLASIIGGQWRKaqgyINPFWLVL--- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 196 natftvfpasalaaaTIALFNLLMIVFWFRETFDPKNRALSETKKIHPIVGVF------NSKNKEVIIYSFLYFIFVFA- 268
Cdd:cd17449 198 ---------------ALNLAAALYAAFCVGESVKEPKSARLFTTRHHQSVVRLyvapapNGSRRKLALYSLALFVVVTVh 262
|
250 260
....*....|....*....|....*
gi 695135051 269 FSGFEFSINFYLSQFLNYSPVAIGF 293
Cdd:cd17449 263 FGAKDLLVLYELSSPLCWDSDLIGY 287
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
279-437 |
7.90e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.55 E-value: 7.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 279 YLSQFLNYSPVAIGFTFVYIGIIIVLIQGgVFRKLSGKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSA 358
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQP-LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSA 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695135051 359 LLHPSLSTLVSLVSSrEEQGTNLGIFRSLASLGRGLAPFVFCLIYFNRGPAISFLTSGLICLLFLVFIWKLKQPNHSLP 437
Cdd:cd17478 100 AFHPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEA 177
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
65-427 |
1.51e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.78 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 65 WPLFVALFG------GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMG 138
Cdd:cd17478 19 LPLLIAKLGlsyaqaGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 139 GNISVASAAMADITNEKDRAKGMGLIGAGVGLGFIAGPPTGGLFakIGPGFLELMFPnatFTVFPAsalaaatialfnLL 218
Cdd:cd17478 99 AAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAAL--VALFGGLGLLI---LLIIPG------------LA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 219 MIVFWFRetfdpKNRALSETKKIHPIVGVFNSKNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFL---NYSPVAIG--- 292
Cdd:cd17478 162 VALLLLR-----LRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLvqrGYSLVFAGlll 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 293 FTFVYIGIIIVLIQGgvfrKLSGKVKETRLVRAGTLSLLVGFSLLYFVSnsyqLFISLTFLASGSALLHPSLSTLVSLVS 372
Cdd:cd17478 237 SLFLFAGAIGTLIGG----PLSDRFGRRRVIIASLLLAAPFLLLFLLTP----GIWSYILLVLAGFLLFASFPVTVVLAQ 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 695135051 373 S--REEQGTNLGIFRSLASLGRGLAPFVFCLIYFNRGPAISFLTSGLICLLFLVFIW 427
Cdd:cd17478 309 EllPGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
70-186 |
2.01e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 46.45 E-value: 2.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 70 ALFGGIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGS-FSLFVFSRVITG-MMGGNISVASAA 147
Cdd:cd17353 248 AGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSvAVLFVLGVALIGfCYGGGFALFPAL 327
|
90 100 110
....*....|....*....|....*....|....*....
gi 695135051 148 MADITNEKDRAKGMGLIGAGVGLGFIAGPPTGGLFAKIG 186
Cdd:cd17353 328 TADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTG 366
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
76-367 |
3.28e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 45.64 E-value: 3.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 76 VASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGN-ISVASAAMADITNE 154
Cdd:cd17503 36 VITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVlIPLAQTILLRIYPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 155 KDRAKGMGLIGAGVGLGFIAGPPTGGLFAKigpgflelmfpNAT-FTVFpasalaaatiaLFNLLM--IVFWFRETFDpk 231
Cdd:cd17503 116 EKRGAAMGLVGLVILLAPAIGPTLGGWLTD-----------NLSwRWIF-----------YINLPIgiLALLLAPLLD-- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 232 nralsetkkihpiVGVFnsKNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFTFVYIGI---IIVLIQGG 308
Cdd:cd17503 172 -------------LRLF--KDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLasaILSPLVGR 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695135051 309 VFRKLSGKvketRLVRAGTLSLLVGFSLLYFV---SNSYQLFISLTFLASGSALLHPSLSTL 367
Cdd:cd17503 237 LLDKFGPR----LLLLAGLLLLALGTLLLAFLtpdTSLWLIILPLFIRGLGMGLVFMPLNTL 294
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
67-425 |
3.45e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.78 E-value: 3.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 67 LFVALFGGIVASLYSLlqfafapiwGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASA 146
Cdd:cd17333 36 IFSSQNAGYLIGSLLA---------GFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGAN 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 147 AMADITNEKDRAKGMGLIGAGVGLGFIAGPPTGGLFAKIGPGFlelmfpnatftvfpasALAAATIALFNLLMIVFWFRE 226
Cdd:cd17333 107 TFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSW----------------SWAYLIIGLIYLLLAILILLT 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 227 TFDPKNRALSETKKIHPIVGVFNSK--NKEVIIYSFLYFIFVFAFSGFEFSINFYL--SQFLNYSPVAIGFTFVYIGIII 302
Cdd:cd17333 171 LFPELPSARNPQQSVGAFSASASRLlrNPSIILGALALFLYVGAETAFSSWVPSYLveKKHVSDGLAGYLLSGFWVGITI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 303 VLIQGGVfrkLSGKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSReEQGTNLG 382
Cdd:cd17333 251 GRLLGGP---ISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPY-AKGKGTS 326
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 695135051 383 IFRSLASLGRGLAPFVFCLIYFNRGPAISFLTSGLICLLFLVF 425
Cdd:cd17333 327 VLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVL 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
255-429 |
3.70e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.74 E-value: 3.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 255 VIIYSFLYFIFVFAFSGFEFSINFYLSQFlNYSPVAIG--FTFVYIGIIIVLIQGGVfrkLSGKVKETRLVRAGTLSLLV 332
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGlvVTAYLLGAALGAPLAGR---LADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 333 GFSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGRGLAPFVFCLIYFNRGPAISF 412
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170
....*....|....*..
gi 695135051 413 LTSGLICLLFLVFIWKL 429
Cdd:COG2814 168 LVNAVLALLALLLLLRL 184
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
76-395 |
6.58e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 44.95 E-value: 6.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 76 VASLYSLLQFAFAPIWGKISDRVGRKPVLVLtsfgSFFGYTIWL----FSGSFSLFVFSRVITGMMGGNISVASAAMADI 151
Cdd:cd17476 38 LAASYSLTVGTFILIFGRLGDIYGHKKMFVI----GSFWFAIWSliagFSPNFIFFIICRALQGLGPAFLLPNAMALLGR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 152 TNEKDRAKGM--GLIGAGVGLGFIAGPPTGGLFAKIGPgflelmfpnatftvFPASALAAATIALFNLLMIVFWFRETFd 229
Cdd:cd17476 114 TYPPGPRKNIvfSLFGATAPLGFALGGVFGGLFAQLAW--------------WPWIFWFLAILAAIVAVAAIFWTSPSF- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 230 pknralsetkkihpivgvfnsknkeviIYSFLYFIFVFA-FSGFEFSINFYLSQFLNYSPVAIGFTFVYIGI--IIVLIQ 306
Cdd:cd17476 179 ---------------------------IAVLLAVFLGWAsFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIggVLAAIT 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 307 GGvfrKLSGKVKETRLVRAGTLSLLVGfSLLYFVSNSYQLFISLTFLAS-----GSALLHPSLSTLVSLVSSREEQGTNL 381
Cdd:cd17476 232 VG---FLIARLPPSYIMAISMVAFLVG-PILFATMPVHQTYWAQAFPAMivapfGMDFSFPAATIIASNAVPREYQGLAG 307
|
330
....*....|....
gi 695135051 382 GIFRSLASLGRGLA 395
Cdd:cd17476 308 SLVNTVVNYGISIG 321
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
72-158 |
8.85e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 44.49 E-value: 8.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 72 FGGIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGM-MGGNISVASAAMAD 150
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVtSAGIFTVGFVLGME 105
|
....*...
gi 695135051 151 ITNEKDRA 158
Cdd:cd17317 106 IVGPKYRS 113
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
74-413 |
9.65e-05 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 44.16 E-value: 9.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVG-RKPVLVLTSFGS---FFGYTIWLFSGSFSLFVFSRVITGMMgGNISVASAAMA 149
Cdd:pfam12832 37 GLITAILPLTRILAPPIWGWLADRTGkRKAVVRLASILAavlFLSVLFIPISLTFWWLALLVVLFSFF-WNAILPQFEVA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 150 DITNEKDRAKGMGLIGAGVGLGF-IAGPPTGGLFAKIGPGFLELMFpnatftvfpasalaaaTIALFNLLMIVFWFRETF 228
Cdd:pfam12832 116 TLQHLGEKRKDYGRQRLWGSVGFaLSVFGLGALFDHYSVGLLPSVL----------------FYLFAALMLLSLLLPLAP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 229 dPKNRALSETKKIHPIVGVFnsKNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQfLNYSPVAIGfTFVYIGIIIVLIQGG 308
Cdd:pfam12832 180 -PEMEYESKGGSKAVFWNLL--KQPEVIIFFLAAFLLGFSHGPFYTFLFLYLEN-LGASNTLLG-ALWALGVVAEIPLFF 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 309 VFRKLSGKVKETRLVRAGTLSLLVGFSLL-YFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSL 387
Cdd:pfam12832 255 YAHRLLRRFGHRNLLIIALLLTALRWLLYaFFVENPWLVLPIQFLHAISFGLTHAAAIEYVRRIFPGSLQGTGQALYSGL 334
|
330 340
....*....|....*....|....*..
gi 695135051 388 A-SLGRGLAPFVFCLIYFNRGPAISFL 413
Cdd:pfam12832 335 YfGLGGALGSLIGGQLWDLFGARFTFR 361
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
82-360 |
1.02e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 44.15 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 82 LLQFAF-------APIWGKISDRVGRKPVLVltsfgsfFGYTIWL-------FSGSFSLFVFSRVITGM-MGGNISVASA 146
Cdd:cd17328 38 LLQTVFiisymvlSPIFGYLGDRYNRKWILA-------VGILIWSaatllssFAPNFWQLLLFRALVGIgEASYSPIAPT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 147 AMADITNEKDRAKGMGLIGAGVGLGFIAGPPTGGLFAKIGPGFlelmfpNATFTVFPASALAaatialfnLLMIVFWFRE 226
Cdd:cd17328 111 IIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGW------RWAFRVTGVLGVL--------LAILLLLFVR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 227 tfDPKnRALSETKKIHPIVG-------VFNSKNKEVIIYSFLYFIFVFAFSGFEFSINFYL---SQFLNYSPVAIGFTF- 295
Cdd:cd17328 177 --EPP-RGAAEGGVMAKSTAtsfladlKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFlraFGVGDLSSADVGLIFg 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695135051 296 ---VYIGIIIVLIQGGVFRKLSGKVKETR-LVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSALL 360
Cdd:cd17328 254 aitCIAGVLGVLLGGILADRLRRKTPRADpLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLL 322
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
90-175 |
2.10e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.36 E-value: 2.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 90 IWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGM-MGGNISVASAAMADITNEKDRAKGMGLIGAGV 168
Cdd:cd17316 55 LFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAEFAPSKRRGFALGLLQSGW 134
|
....*..
gi 695135051 169 GLGFIAG 175
Cdd:cd17316 135 ALGALLA 141
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
11-181 |
2.23e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.35 E-value: 2.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 11 NKTSFVLFFTVFIDMMGFSVIFPIFPEMLKTFLSKSGDpvldkftdftkiltgdwplfvalFGGIVASLYSLLQFAFAPI 90
Cdd:COG2211 227 NRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAA-----------------------LVGLLLALYFLAALLGAPL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 91 WGKISDRVGRKPVLVLTSFGSFFGYTIWLFSG--SFSLFVFSRVITGMMGGNISVASAAM-ADI-------TNEKDRAKG 160
Cdd:COG2211 284 WPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMlADVvdydewkTGRRREGLY 363
|
170 180
....*....|....*....|.
gi 695135051 161 MGLIGAGVGLGFIAGPPTGGL 181
Cdd:COG2211 364 FGIFTFAIKLGQALAGALAGL 384
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
74-426 |
2.25e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.32 E-value: 2.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVAS-AAMADIT 152
Cdd:cd17477 34 GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 153 NEKDRAKGMGLIGAGVGLGFIAGPPTGGLfakigpgflelmFPNATFTVFpasaLAAATIALFNLLMIVFWFRETFDPKN 232
Cdd:cd17477 114 TNENRGRVLGLYSTVLGLGFALGPLLLAL------------VGTAGALPF----LIAAVLLLLALVPLLLTRRAAPEIEE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 233 RAlsetkkihpivgvfNSKNKEVIIYSFLYFIFVFAFSGFEFSIN----FYLSQF-LNYSPVAIGFTFVYIGIIIVLIQG 307
Cdd:cd17477 178 AE--------------SISLRRLLRIAPLALLGAFVAGFLEGAFYsllpLYGLRLgLSVAQAALLLAAFVLGGLLLQWPL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 308 GvfrKLSGKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSALlhpSLSTL-VSLVSSREEQG---TNLGI 383
Cdd:cd17477 244 G---WLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAG---PLYTLaLALAGDRLPGDelvAANAA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 695135051 384 FRSLASLGRGLAPFVFCLIYFNRGPAISFLTSGLICLLFLVFI 426
Cdd:cd17477 318 LLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
82-352 |
5.18e-04 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 41.99 E-value: 5.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 82 LLQFAFAP-IWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAMA-DITNEKDRAK 159
Cdd:TIGR00710 50 LLGFAAGQlLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVrDIYPGEELSR 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 160 GMGLIGAGVGLGFIAGPPTGGLfakigpgFLELMFPNATFTVFpasalaaATIALFNLLMIVFWFRETFDPKNRALSETk 239
Cdd:TIGR00710 130 IYSILMPVLALAPAVAPLLGGY-------ILVWLSWHAIFAFL-------SLAGILLSALIFFILPETLPYEARIQIST- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 240 kihpIVGVFNS--KNKEVIIYSFLYFIFVFAFSGFEFSINFYLSQFLNYSPVAIGFTFVyIGIIIVLIQGGVFRKLSGKV 317
Cdd:TIGR00710 195 ----YFETFLLllKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFA-LNIIAMIFGGFLNGRFIKKW 269
|
250 260 270
....*....|....*....|....*....|....*
gi 695135051 318 KETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTF 352
Cdd:TIGR00710 270 GAKSLLRMGLILFAVSAVLLEITAILGLGSWAMII 304
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
74-421 |
6.14e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 41.84 E-value: 6.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVG-----RKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRV--------ITGMMGGN 140
Cdd:cd17313 37 GFVWTLGPILGLFVQPLVGSLSDRCNsrigrRRPFILVGAPLAALGLILIPNAADIGLALGDGPrtwalvlfVLGIVLLD 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 141 ISVAS------AAMADITNEKDRAKGMGLIGAGVGLGFIAGPPTGG-LFAKIGPGFLELMFPNATFTVFPASALAAATIA 213
Cdd:cd17313 117 FAMNVcqgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAiLWDHNWFGFALGGNLKVPFYIGAIILLVCVLVT 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 214 LFNLLMIVFWFRETFDPKNRALSETKKihPIVGVFNSKNKEVIIYSFLYFIFVFAFSGFEF------SINFYLSQFLNYS 287
Cdd:cd17313 197 LFFVKEPPLSPEAGEHSENPSLGEVLK--SLLKLLKIMPRSLLRLLLVIFFWWIAFFPFELfftdymGEEVYHGTSAASS 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 288 PVAIGFTFVYIGIIIVLIQGGVF----RKLSGKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSALLHPS 363
Cdd:cd17313 275 HYGAGVRMGAWGLLIFSLAFLIFslpiGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININ 354
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695135051 364 LSTLVSLV--SSREEQGTNLGIFRS-------LASLGRGLAPFVFCLIYFNRGPAISFLTSGLICLL 421
Cdd:cd17313 355 PYPLVSDYhsESGRGQGTDTGLLNLaislaqiLVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
74-427 |
7.28e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 41.42 E-value: 7.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGS--FFGYTIWLFSGSFSLFVFSRVITGMMGGNIS--VASAAMA 149
Cdd:cd17335 35 GILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAavLFFLSLFFVAQIFWLLLLLVILGAFFSAPVVplVDSITLQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 150 DITNEKDRAKGMGLIGAgvgLGFIAGPP-TGGLFAKIGPGFLelmfPNATFTVFpasalaaatIALFNLLMIVFWFRETF 228
Cdd:cd17335 115 YLGEERERYGKQRLWGS---IGFGIAALlVGILIDRSSTYKN----YTIAFYVF---------AVLMLLALLLALKFPFR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 229 DPKNRALSETKKIHPIVgvfnsKNKEVIIysFLYFIFVFAFS-GFEFSINFYLSQFLNYSPVAIGFTFV--YIGIIIVLI 305
Cdd:cd17335 179 PKHPEPNENTGGLLALL-----RNPRVLA--FLLVAFLMGFGhGLIYSFLFWHLQDLGGSKTLIGLLWTvgVVSEIPFFF 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 306 QGGvfrKLSGKVKETRLVRAGTLSLLVGFSLLYFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFR 385
Cdd:cd17335 252 FSS---RLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQGLLQ 328
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 695135051 386 SLAS-LGRGLAPFVFCLIYFNRGPAISFLTSGLICLLFLVFIW 427
Cdd:cd17335 329 GLYFgLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFF 371
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
74-194 |
7.34e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 41.43 E-value: 7.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSF---FGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAMAD 150
Cdd:cd17316 216 SLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGilaLPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAE 295
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 695135051 151 ITNEKDRAKGMGLIGAGVGLGFIAGPPTGGLFAKIGPGFLELMF 194
Cdd:cd17316 296 LFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPAL 339
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
69-172 |
9.67e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 41.36 E-value: 9.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 69 VALFGGIVASLyslLQFAFAPIWGKISDRVGRKPVLVLTSFGS---FFGYTIWLFSGSFSLFVFSRVITGM--MGGNISV 143
Cdd:cd17369 265 TVLLAVLIASV---VAAITIPLFGWLSDRVGRRPVYLAGALLAalfAFPFFWLLDTGSTWLIVLAAVVVLGvlHGMMYGP 341
|
90 100 110
....*....|....*....|....*....|..
gi 695135051 144 ASAAMADITNEKDRAKGMGL---IGAGVGLGF 172
Cdd:cd17369 342 QAAFLAELFPTRVRYTGASLgyqLGAILGGGF 373
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
65-182 |
3.83e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.08 E-value: 3.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 65 WPLFVALFGGIvaslysLLQFafaPIwGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFS--LFVFSRVITGMMGGNIS 142
Cdd:cd17477 227 LLLAAFVLGGL------LLQW---PL-GWLADRFDRRRVLLGCALLGALAALLLPLVPGLPlaLLVLLFLWGGAAGPLYT 296
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 695135051 143 VASAAMADITNEKDRAKGMGLIGAGVGLGFIAGPPTGGLF 182
Cdd:cd17477 297 LALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGAL 336
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
263-425 |
7.17e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.31 E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 263 FIFVFAFSGFEFSINF---YLSQFLNYSPVAIG--FTFVYIGIIIVLIQGGVfrkLSGKVKETRLVRAGTLSLLVGFSLL 337
Cdd:COG2271 16 FLAYFLNYLDRSNLSVaapPLQADLGLSAAQLGllASAFFLGYALGQIPAGL---LADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 338 YFVSNSYQLFISLTFLASGSALLHPSLSTLVSLVSSREEQGTNLGIFRSLASLGRGLAPFVFCLIYFNRGPAISFLTSGL 417
Cdd:COG2271 93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGL 172
|
....*...
gi 695135051 418 ICLLFLVF 425
Cdd:COG2271 173 PGLLLALL 180
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
80-136 |
8.05e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 38.35 E-value: 8.05e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 695135051 80 YSLLQFafapIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGM 136
Cdd:PRK11652 56 YGLSQL----FYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGL 108
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
74-181 |
8.24e-03 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 38.06 E-value: 8.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGMMGGNISVASAAM-AD-I 151
Cdd:cd17383 33 GVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTAGLAMiADrF 112
|
90 100 110
....*....|....*....|....*....|
gi 695135051 152 TNEKDRAKGMGLIGAGVGLGFIAGPPTGGL 181
Cdd:cd17383 113 TEEAERSKALGIALAFISFGCLVAPPFGGI 142
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
74-159 |
8.37e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 38.42 E-value: 8.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 74 GIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLT-SFGSFFGYTIWLFSGsFSLFVFSRVITGM-MGGNISVASAAMADI 151
Cdd:TIGR01299 205 GMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLIClSVNGFFAFFSSFVQG-YGFFLFCRLLSGFgIGGAIPIVFSYFAEF 283
|
....*...
gi 695135051 152 TNEKDRAK 159
Cdd:TIGR01299 284 LAQEKRGE 291
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
68-189 |
8.72e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.05 E-value: 8.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695135051 68 FVALFGGIVASLYSLLQFAFAPIWGKISDRVGRKPVLVLTSFGSFFGYTIWLFSGSFSLFVFSRVITGmmGGNISVASAA 147
Cdd:cd06180 228 AGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFG--GTFMAITALV 305
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 695135051 148 MADITN--EKDRAKGMGLIGAGVGLGFIAGPPTGGLFAKIGPGF 189
Cdd:cd06180 306 MALARElaPPAAPRALALMTASFGVGQILGPLLAGWLADATGGF 349
|
|
| |
