|
Name |
Accession |
Description |
Interval |
E-value |
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
1-875 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 1613.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 1 MEMKPKYDPREVEKGRYEEWVSNGYFKPSEDKSKEAYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPG 80
Cdd:COG0525 1 MELPKTYDPKEVEAKWYQYWEENGYFKADPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 81 MDHAGIATQAKVEAKLNEQGISRHDLGREKFLQQAWDWKEEYATFIRQQWAKLGLGLDYSRERFTLDDGLSKAVRKVFVD 160
Cdd:COG0525 81 TDHAGIATQAVVERQLAEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 161 LYNKGIIYRGERIINWDPKARTALSDIEVIHEDVQGAFYHFKYPYADGNGYIEIATTRPETMLGDTAIVVNPNDERYKDV 240
Cdd:COG0525 161 LYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYPLADGSGYIVVATTRPETMLGDTAVAVHPEDERYKHL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 241 IGKTVILPIVGRELPILADEYVDIEFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDEYGKMNEKADKYKGMDRFDCRNQ 320
Cdd:COG0525 241 IGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENAGKYRGLDRFEARKA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 321 LVKDLKEQDLVIKIEEHTHSVGHSERSGAIVEPYLSTQWFVKMKPLAQRALDNQNtKDRIDFFPGRFENTFNRWMEEIRD 400
Cdd:COG0525 321 IVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVE-DGEIKFVPERWEKTYFHWMENIRD 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 401 WTISRQLWWGHQIPAWYHKDtGEVFVGEEAPE-----DIENWIQDEDVLDTWFSSALWPFSTLGWPDtNADDFKRYYPTN 475
Cdd:COG0525 400 WCISRQLWWGHRIPAWYCPD-GEVYVARTEPEacakaGSVNLTQDEDVLDTWFSSALWPFSTLGWPE-KTEDLKYFYPTS 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 476 ALVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGH 555
Cdd:COG0525 478 VLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGR 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 556 DLRYSTEKVESVWNFINKIWNAARFSLMNiGEDFKVEDIDLSGNLSLADQWILTRLNETISTVTELSEKYEFGEVGRALY 635
Cdd:COG0525 558 DIKFDEERVEGYRNFANKLWNASRFVLMN-LEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALY 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 636 NFIWDEFCDWYIEMSKIPMNGEDESQKQTTRSVLSYVLDKIMKMLHPFMPFVTETIWQSLP--HHGETIVKASWPTVDQA 713
Cdd:COG0525 637 DFVWNEFCDWYLELAKPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPprKEGESIMLAPWPEADEE 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 714 LIFNESKQTMEQLVEIIKSVRQSRVEVNTPLSKAIPILIQTKDEKIKQTLMDNISYLHKFCNPSQLTIDTEiEIPEKAMT 793
Cdd:COG0525 717 LIDEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITILVD-EKPEGAAS 795
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 794 SVVVAGKVVLPLEGLIDMDKEIARLEKELDKLQSELDRVDKKLSNENFVNKAPEKIINEEKEKQQHYQEKYNGVKSRIEQ 873
Cdd:COG0525 796 AVVGGAEVFLPLEGLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAEAKLEKLEEQLAR 875
|
..
gi 394254284 874 LK 875
Cdd:COG0525 876 LK 877
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
1-876 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 1605.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 1 MEMKPKYDPREVEKGRYEEWVSNGYFKPsEDKSKEAYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPG 80
Cdd:PRK05729 3 MELPKTYDPKEVEAKWYQKWEEKGYFKP-DDNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 81 MDHAGIATQAKVEAKLNEQGISRHDLGREKFLQQAWDWKEEYATFIRQQWAKLGLGLDYSRERFTLDDGLSKAVRKVFVD 160
Cdd:PRK05729 82 TDHAGIATQMVVERQLAAEGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 161 LYNKGIIYRGERIINWDPKARTALSDIEVIHEDVQGAFYHFKYPYADGNGYIEIATTRPETMLGDTAIVVNPNDERYKDV 240
Cdd:PRK05729 162 LYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGKLWHIRYPLADGSDYLVVATTRPETMLGDTAVAVNPEDERYKHL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 241 IGKTVILPIVGRELPILADEYVDIEFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDEYGKMNEKADKYKGMDRFDCRNQ 320
Cdd:PRK05729 242 IGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINENPGEYQGLDRFEARKA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 321 LVKDLKEQDLVIKIEEHTHSVGHSERSGAIVEPYLSTQWFVKMKPLAQRALDNQNtKDRIDFFPGRFENTFNRWMEEIRD 400
Cdd:PRK05729 322 IVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVE-NGEIKFVPERWEKTYFHWMENIQD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 401 WTISRQLWWGHQIPAWYHKDtGEVFVGEEAPEDIEN--WIQDEDVLDTWFSSALWPFSTLGWPDtNADDFKRYYPTNALV 478
Cdd:PRK05729 401 WCISRQLWWGHRIPAWYDED-GEVYVGREEPEAREKalLTQDEDVLDTWFSSALWPFSTLGWPE-KTEDLKRFYPTSVLV 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 479 TGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLR 558
Cdd:PRK05729 479 TGFDIIFFWVARMIMMGLHFTGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIR 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 559 YSTEKVESVWNFINKIWNAARFSLMNIGEDfKVEDIDLSGNLSLADQWILTRLNETISTVTELSEKYEFGEVGRALYNFI 638
Cdd:PRK05729 559 FDEERVEGYRNFANKLWNASRFVLMNLEGA-DVGELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFI 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 639 WDEFCDWYIEMSKIPMNGEdesQKQTTRSVLSYVLDKIMKMLHPFMPFVTETIWQSLPHHG--ETIVKASWPTVDQALiF 716
Cdd:PRK05729 638 WNEFCDWYLELAKPVLQEA---AKRATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGieESIMLAPWPEADEAI-D 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 717 NESKQTMEQLVEIIKSVRQSRVEVNTPLSKAIPILIQTKDEKIKQTLMDNISYLHKFCNPSQLTIDTEIE-IPEKAMTSV 795
Cdd:PRK05729 714 EAAEAEFEWLKELITAIRNIRAEMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLARLESLEILADDEeAPEGAASAV 793
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 796 VVAGKVVLPLEGLIDMDKEIARLEKELDKLQSELDRVDKKLSNENFVNKAPEKIINEEKEKQQHYQEKYNGVKSRIEQLK 875
Cdd:PRK05729 794 VGGAELFLPLEGLIDVEAELARLEKELAKLEKEIERVEKKLSNEGFVAKAPEEVVEKEREKLAEYEEKLAKLKERLARLK 873
|
.
gi 394254284 876 A 876
Cdd:PRK05729 874 A 874
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
3-857 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 1229.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 3 MKPKYDPREVEKGRYEEWVSNGYFKPSEDKSKEAYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMD 82
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 83 HAGIATQAKVEAKLNEQGISRHDLGREKFLQQAWDWKEEYATFIRQQWAKLGLGLDYSRERFTLDDGLSKAVRKVFVDLY 162
Cdd:TIGR00422 81 HAGIATQVKVEKKLGAEGKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 163 NKGIIYRGERIINWDPKARTALSDIEVIHEDVQGAFYHFKYPYADG-NGYIEIATTRPETMLGDTAIVVNPNDERYKDVI 241
Cdd:TIGR00422 161 EKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLANGsKDYLVVATTRPETMFGDTAVAVHPEDERYKHLI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 242 GKTVILPIVGRELPILADEYVDIEFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDEYGKMNEKADKYKGMDRFDCRNQL 321
Cdd:TIGR00422 241 GKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLNENAGKYQGLTRFEARKKI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 322 VKDLKEQDLVIKIEEHTHSVGHSERSGAIVEPYLSTQWFVKMKPLAQRALDNQNTKDrIDFFPGRFENTFNRWMEEIRDW 401
Cdd:TIGR00422 321 VEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEGE-IKFVPKRMEKRYLNWLRNIKDW 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 402 TISRQLWWGHQIPAWYHKDTGEVFVGEEAPEDIE--------NWIQDEDVLDTWFSSALWPFSTLGWPDtNADDFKRYYP 473
Cdd:TIGR00422 400 CISRQLIWGHRIPVWYCKECGEVYVAKEEPLPDDktntgpsvELEQDTDVLDTWFSSSLWPFSTLGWPD-ETKDLKKFYP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 474 TNALVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSP 553
Cdd:TIGR00422 479 TDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTP 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 554 GHDLRYSTEKVESVWNFINKIWNAARFSLMNIGEDFKVEdiDLSGNLSLADQWILTRLNETISTVTELSEKYEFGEVGRA 633
Cdd:TIGR00422 559 GDDINFDWKRVESARNFLNKLWNASRFVLMNLSDDLELS--GGEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKA 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 634 LYNFIWDEFCDWYIEMSKIPMNGEDESQKQTTRSVLSYVLDKIMKMLHPFMPFVTETIWQSLPHHGETIVKASWPTVDQA 713
Cdd:TIGR00422 637 LYEFIWNDFCDWYIELVKYRLYNGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGADSIMLQSYPVVDAE 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 714 LIFNESKQTMEQLVEIIKSVRQSRVEVNTPLSKAIPILIQTKDEKIKQTLMDNISYLHKFCNPSQLTIDTEIEIPEKAMT 793
Cdd:TIGR00422 717 FVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERLKLNAVDIKGAINFSEVEVVIEKPEVTEAVV 796
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 394254284 794 SVVVAGKVVLPLEGLIDMDKEIARLEKELDKLQSELDRVDKKLSNENFVNKAPEKIINEEKEKQ 857
Cdd:TIGR00422 797 ELVPGFEIIIPVKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKEKEKL 860
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
2-863 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 945.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 2 EMKPKYDPREVEKGRYEEWVSNGYFKPSE-DKSKEAYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPG 80
Cdd:PRK14900 14 ELAKGYEHREVEARWYPFWQERGYFHGDEhDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 81 MDHAGIATQAKVEAKLNE-QGISRHDLGREKFLQQAWDWKEEYATFIRQQWAKLGLGLDYSRERFTLDDGLSKAVRKVFV 159
Cdd:PRK14900 94 TDHAGIATQMIVEKELKKtEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 160 DLYNKGIIYRGERIINWDPKARTALSDIEVIHEDV-QGAFYHFKYPYADGNGYIEIATTRPETMLGDTAIVVNPNDERYK 238
Cdd:PRK14900 174 RLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAhQGELWSFAYPLADGSGEIVVATTRPETMLGDTAVAVHPLDPRYM 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 239 DVIGKTVILPIVGRELPILAD-EYVDIEFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDEYGKMNEKADKYKGMDRFDC 317
Cdd:PRK14900 254 ALHGKKVRHPITGRTFPIVADaILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEAGPLAGLDRFEA 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 318 RNQLVKDLKEQDLVIKIEEHTHSVGHSERSGAIVEPYLSTQWFVKMKPLAQRALDNQNtKDRIDFFPGRFENTFNRWMEE 397
Cdd:PRK14900 334 RKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEAVE-QGRTRFIPEQWTNTYMAWMRN 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 398 IRDWTISRQLWWGHQIPAWYHKDtGEVFVGEEAPEDIE-----NWIQDEDVLDTWFSSALWPFSTLGWPDtNADDFKRYY 472
Cdd:PRK14900 413 IHDWCISRQLWWGHQIPAWYCPD-GHVTVARETPEACStcgkaELRQDEDVLDTWFSSGLWPFSTMGWPE-QTDTLRTFY 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 473 PTNALVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSS 552
Cdd:PRK14900 491 PTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLAALTA 570
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 553 PGHDLRYSTEKVESVWNFINKIWNAARFSLMNIGEdFKVEDIDLS-GNLSLADQWILTRLNETISTVTELSEKYEFGEVG 631
Cdd:PRK14900 571 QGRDIKLAKERIEGYRAFANKLWNASRFALMNLSG-YQERGEDPArLARTPADRWILARLQRAVNETVEALEAFRFNDAA 649
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 632 RALYNFIWDEFCDWYIEMSKIPMNGEDESQKQTTRSVLSYVLDKIMKMLHPFMPFVTETIWQSLPHH------GETIVKA 705
Cdd:PRK14900 650 NAVYAFVWHELCDWYIELAKEALASEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRAQvgasawADSVLAA 729
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 706 SWPTVDQAliFNESKQTMEQLVEIIKSVRQSRVEVNTP----LSKAIPILIQTKDEKIKQTLMDN-ISYLHKFCNPSqlt 780
Cdd:PRK14900 730 EYPRKGEA--DEAAEAAFRPVLGIIDAVRNIRGEMGIPwkvkLGAQAPVEIAVADPALRDLLQAGeLARVHRVAGVE--- 804
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 781 iDTEIEI---PEKAMTSVVVAG---KVVLPLEGLIDMDKEIARLEKELDKLQSELDRVDKKLSNENFVNKAPEKIINEEK 854
Cdd:PRK14900 805 -GSRLVVaaaTAPAPQSAVGVGpgfEVRVPLAGVIDLAAETARVDKEIGKVDQDLAVLERKLQNPSFVQNAPPAVVEKDR 883
|
....*....
gi 394254284 855 EKQQHYQEK 863
Cdd:PRK14900 884 ARAEELREK 892
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
2-875 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 936.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 2 EMKPKYDPREVEKGRYEEWVSNGYFKPSED----KSKEAYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLY 77
Cdd:PTZ00419 23 SMAASYDPKEVESGWYEWWEKSGFFKPAEDakslNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 78 LPGMDHAGIATQAKVEAKL-NEQGISRHDLGREKFLQQAWDWKEEYATFIRQQWAKLGLGLDYSRERFTLDDGLSKAVRK 156
Cdd:PTZ00419 103 VPGTDHAGIATQVVVEKKLmKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 157 VFVDLYNKGIIYRGERIINWDPKARTALSDIEVIHEDVQ----------------GAFYHFKYPYADGN-GYIEIATTRP 219
Cdd:PTZ00419 183 AFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEkptkitipgydkkvevGVLWHFAYPLEDSGqEEIVVATTRI 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 220 ETMLGDTAIVVNPNDERYKDVIGKTVILP-IVGRELPILADE-YVDIEFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMD 297
Cdd:PTZ00419 263 ETMLGDVAVAVHPKDERYKKLHGKELIHPfIPDRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFT 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 298 EYGKMNEKADKYKGMDRFDCRNQLVKDLKEQDLVIKIEEHTHSVGHSERSGAIVEPYLSTQWFVKMKPLAQRALDNQNTK 377
Cdd:PTZ00419 343 LDGKINENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAVRNG 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 378 DrIDFFPGRFENTFNRWMEEIRDWTISRQLWWGHQIPAWyhKDTGEVFVGEEAPEdiENWI------------------- 438
Cdd:PTZ00419 423 E-LKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAY--RVISKGPETDPSDE--EPWVvarseeealekakkkfgls 497
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 439 -------QDEDVLDTWFSSALWPFSTLGWPDTNaDDFKRYYPTNALVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHG 511
Cdd:PTZ00419 498 eedfeleQDEDVLDTWFSSGLFPFSTLGWPDQT-DDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHA 576
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 512 LVRAEDGRKMSKSLGNGVDPMDVID-------------------------------------EYGADSLRYFLATGSSPG 554
Cdd:PTZ00419 577 MVRDSQGEKMSKSKGNVIDPLEVIEgislqdlnqklyegnlpekeikraielqkkefpngipECGTDALRFGLLAYTQQG 656
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 555 HDLRYSTEKVESVWNFINKIWNAARFSLMNIGEDFKVEDIDLSGN-----LSLADQWILTRLNETISTVTELSEKYEFGE 629
Cdd:PTZ00419 657 RNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLPNSTLFKPnnvesLPWEDKWILHRLNVAIKEVTEGFKEYDFSE 736
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 630 VGRALYNFIWDEFCDWYIEMSK-IPMNGEDESQKQTTRSVLSYVLDKIMKMLHPFMPFVTETIWQSLPHH---GETIVKA 705
Cdd:PTZ00419 737 ATQATYNFWLYELCDVYLELIKpRLSKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNYlrkSESISIA 816
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 706 SWPTVDQALIFNESKQTMEQLVEIIKSVRQSRVEVNTPLSKAIPILIQTKDEKIKQTLMDN---ISYLHKFCNPSQLTID 782
Cdd:PTZ00419 817 KYPQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAELIELIESAenlISTLAKIGSVSVIPPI 896
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 783 TEIEIPEKAMTSVVVAGKVV--LPLEGLIDMDKEIARLEKELDKLQSELDRVDKKLSNENFVNKAPEKIINEEKEKQQHY 860
Cdd:PTZ00419 897 EEEAEVPKGCGFDVVDNKVIiyLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKISIPNYEDKVPEDVRKLNDEKIDEL 976
|
970
....*....|....*
gi 394254284 861 QEKYNGVKSRIEQLK 875
Cdd:PTZ00419 977 NEEIKQLEQAIEELK 991
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
13-876 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 846.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 13 EKGRYEEWVSNGYFKPSEDKSKEAYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKV 92
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVV 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 93 EAKLNEQGISRHDLGREKFLQQAWDWKEEYATFIRQQWAKLGLGLDYSRERFTLDDGLSKAVRKVFVDLYNKGIIYRGER 172
Cdd:PLN02943 146 EKMLASEGIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSY 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 173 IINWDPKARTALSDIEVIHEDVQGAFYHFKYPYADG-NGYIEIATTRPETMLGDTAIVVNPNDERYKDVIGKTVILPIV- 250
Cdd:PLN02943 226 MVNWSPNLQTAVSDLEVEYSEEPGTLYYIKYRVAGGsEDFLTIATTRPETLFGDVAIAVNPEDDRYSKYIGKMAIVPMTy 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 251 GRELPILADEYVDIEFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDEYGKMNEKAdkykGMDRFDCRNQLVKDLKEQDL 330
Cdd:PLN02943 306 GRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVA----GLYWFEAREKLWSDLEETGL 381
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 331 VIKIEEHTHSVGHSERSGAIVEPYLSTQWFVKMKPLAQRALDN-QNTKDRIdfFPGRFENTFNRWMEEIRDWTISRQLWW 409
Cdd:PLN02943 382 AVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAvENGELTI--IPERFEKIYNHWLSNIKDWCISRQLWW 459
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 410 GHQIPAWY--HKDTGEVFV----GEEAPE--------DIENWiQDEDVLDTWFSSALWPFSTLGWPDTNADDFKRYYPTN 475
Cdd:PLN02943 460 GHRIPVWYivGKDCEEDYIvarsAEEALEkarekygkDVEIY-QDPDVLDTWFSSALWPFSTLGWPDVSAEDFKKFYPTT 538
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 476 ALVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSpGH 555
Cdd:PLN02943 539 VLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTA-GQ 617
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 556 DLRYSTEKVESVWNFINKIWNAARFSLMNIGE-------------DFKVEDIDLSgnLSLADQWILTRLNETISTVTELS 622
Cdd:PLN02943 618 DLNLSTERLTSNKAFTNKLWNAGKFVLQNLPSqsdtsawehilacKFDKEESLLS--LPLPECWVVSKLHELIDSVTTSY 695
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 623 EKYEFGEVGRALYNFIWDEFCDWYIEMSKIPMNG-EDESQKQTTRSVLSYVLDKIMKMLHPFMPFVTETIWQSLPHHGET 701
Cdd:PLN02943 696 DKYFFGDVGREIYDFFWSDFADWYIEASKTRLYHsGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALPYRKEA 775
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 702 IVKASWPTVDQALiFNESKQTMEQLVEIIKSVRQSRVEVNTPLSKAIPILIQTKDEkikqtlmdNISYLHK----FCNPS 777
Cdd:PLN02943 776 LIVSPWPQTSLPK-DLKSIKRFENLQSLTRAIRNARAEYSVEPAKRISASIVASAE--------VIEYISKekevLALLS 846
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 778 QLTIDT---EIEIPEKAMTSV-VVAGK---VVLPLEGLIDMDKEIARLEKELDKLQSELDRVDKKLSNENFVNKAPEKII 850
Cdd:PLN02943 847 RLDLQNvhfTDSPPGDANQSVhLVASEgleAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEKAPEDVV 926
|
890 900
....*....|....*....|....*.
gi 394254284 851 NEEKEKQQHYQEKYNGVKSRIEQLKA 876
Cdd:PLN02943 927 RGVREKAAEAEEKIKLTKNRLAFLKS 952
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
15-560 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 720.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 15 GRYEEWVSNGYFKPS--EDKSKEAYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKV 92
Cdd:pfam00133 1 QIYEFWDEQGYFKPEleKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 93 EAKLN-EQGISRHDLGREKFLQQAWDWKEEYATFIRQQWAKLGLGLDYSRERFTLDDGLSKAVRKVFVDLYNKGIIYRGE 171
Cdd:pfam00133 81 EKKLGiKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 172 RIINWDPKARTALSDIEVIHEDVQGAFYHFKYPYADGNG-YIEIATTRPETMLGDTAIVVNPN----------------- 233
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVEYKDVKGPSIHVAFPLADDEGaSLVIWTTTPWTLPGNTAVAVNPEfdyvitgegyilaeall 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 234 --------------DERYKDVIGKTVILPIVGRELPILADEYVDIEFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDEY 299
Cdd:pfam00133 241 kslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDDD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 300 GKMNEKADKYKGMDRFDCRNQLVKDLKEQDLVIKIEEHTHSVGHSERSGAIVEPYLSTQWFVKMKPLAQRALDNQntkDR 379
Cdd:pfam00133 321 GTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAV---EK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 380 IDFFPGRFENTFNRWMEEIRDWTISRQLWWGHQIPAWYHKDTGEVFVGEE---------APEDIENWI------------ 438
Cdd:pfam00133 398 VQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGElfelvagrfEEEGSIKWLhreakdklgygk 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 439 ----QDEDVLDTWFSSALWPFSTLGWPDTNADDFKRYYPTNALVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVR 514
Cdd:pfam00133 478 gtleQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVR 557
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 394254284 515 AEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLAtGSSPGHDLRYS 560
Cdd:pfam00133 558 DEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLA-NSDYGRDINLS 602
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
2-876 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 691.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 2 EMKPKYDPREVEKGRYEEWVSNGYFKPSEDKSKEAYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGM 81
Cdd:PLN02381 95 QMAKQYSPSAVEKSWYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGV 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 82 DHAGIATQAKVEAKL-NEQGISRHDLGREKFLQQAWDWKEEYATFIRQQWAKLGLGLDYSRERFTLDDGLSKAVRKVFVD 160
Cdd:PLN02381 175 DHAGIATQVVVEKKLmRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVR 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 161 LYNKGIIYRGERIINWDPKARTALSDIEVIHEDVQ----------------GAFYHFKYPYADGNGYIEIATTRPETMLG 224
Cdd:PLN02381 255 LYKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKertllkvpgydkpvefGVLTSFAYPLEGGLGEIVVATTRIETMLG 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 225 DTAIVVNPNDERYKDVIGKTVILPIVGRELPILAD-EYVDIEFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDEYGKMN 303
Cdd:PLN02381 335 DTAIAIHPDDERYKHLHGKFAVHPFNGRKLPIICDaILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKIN 414
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 304 EKA-DKYKGMDRFDCRNQLVKDLKEQDLVIKIEEHTHSVGHSERSGAIVEPYLSTQWFVKMKPLAQRALDNQNTKD--RI 380
Cdd:PLN02381 415 SNGgSEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSMAKQALDAAIDGEnkKL 494
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 381 DFFPGRFENTFNRWMEEIRDWTISRQLWWGHQIPAWY-------HKDTGEV----FVG---EEAPEDIE--------NWI 438
Cdd:PLN02381 495 EFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYvtleddqLKELGSYndhwVVArneSDALLEASqkfpgkkfELS 574
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 439 QDEDVLDTWFSSALWPFSTLGWPDtNADDFKRYYPTNALVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDG 518
Cdd:PLN02381 575 QDPDVLDTWFSSGLFPLSVLGWPD-DTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHG 653
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 519 RKMSKSLGNGVDPMDVID-------------------------------------EYGADSLRYFLATGSSPGHDLRYST 561
Cdd:PLN02381 654 RKMSKSLGNVIDPLEVINgisleglhkrleegnldpkelvvakegqkkdfpngiaECGTDALRFALVSYTAQSDKINLDI 733
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 562 EKVESVWNFINKIWNAARFSLMNIGEDFKVEDIDLSGNLSLADQWILTRLNETIS-TVTELsEKYEFGEVGRALYNFIWD 640
Cdd:PLN02381 734 LRVVGYRQWCNKLWNAVRFAMSKLGDDYTPPATLSVETMPFSCKWILSVLNKAISkTVSSL-DAYEFSDAASTVYSWWQY 812
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 641 EFCDWYIEMSKIPMNGED---ESQKQTTRSVLSYVLDKIMKMLHPFMPFVTETIWQSLPH-----HGETIVKASWPTVDQ 712
Cdd:PLN02381 813 QFCDVFIEAIKPYFAGDNpefASERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPQpkdhtRKDSIMISEYPSAVE 892
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 713 ALIFNESKQTMEQLVEIIKSVRQSRVEV-NTPLSKAIPILIQTKDEKIKQTLMDNISYLHKFCNPSQLTI--DTEIEIPE 789
Cdd:PLN02381 893 AWTNEKVEYEMDLVLSTVKCLRSLRAEVlEKQKNERLPAFALCRNQEIAAIIKSHQLEILTLANLSSLKVllSENDAPPA 972
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 790 KAMTSVVVAG-KVVLPLEGLIDMDKEIARLEKELDKLQSELDRVDKKLSNENFVNKAPEKIINEEKEKQQHYQEKYNGVK 868
Cdd:PLN02381 973 GCAFENVNENlKVYLQAQGAVNAEAELEKLRNKMDEIQKQQEKLEKKMNASGYKEKVPANIQEEDARKLTKLLQELEFFE 1052
|
....*...
gi 394254284 869 SRIEQLKA 876
Cdd:PLN02381 1053 KESKRLEA 1060
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-791 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 658.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 1 MEMKPKYDPREVEKGRYEEWVSNGYFKPSEDKSKEAYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPG 80
Cdd:PRK13208 4 PELPKKYDPEELEEKWQKIWEEEGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 81 MDHAGIATQAKVEaklNEQGISRHDLGREKFLQQAWDWKEEYATFIRQQWAKLGLGLDYSRERFTLDDGLSKAVRKVFVD 160
Cdd:PRK13208 84 WDDNGLPTERKVE---KYYGIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 161 LYNKGIIYRGERIINWDPKARTALSDIEVIHEDVQGAFYHFKYPYADGnGYIEIATTRPETMLGDTAIVVNPNDERYKDV 240
Cdd:PRK13208 161 LYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVEDG-EEIEIATTRPELLPACVAVVVHPDDERYKHL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 241 IGKTVILPIVGRELPILADEYVDIEFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDEYGKMNEKADKYKGMDRFDCRNQ 320
Cdd:PRK13208 240 VGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTIEEARKK 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 321 LVKDLKEQDLVIKIEEHTHSVGHSERSGAIVEPYLSTQWFVKMKPLAQRALDnqnTKDRIDFFPG----RFENtfnrWME 396
Cdd:PRK13208 320 IVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLE---RGKEINWYPEhmrvRLEN----WIE 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 397 EIR-DWTISRQLWWGHQIPAWYHKDTGEVFVGEEA-----------PEDIE------NWIQDEDVLDTWFSSALWPFSTL 458
Cdd:PRK13208 393 GLNwDWCISRQRYFGTPIPVWYCKDCGHPILPDEEdlpvdptkdepPGYKCpqcgspGFEGETDVMDTWATSSITPLIVT 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 459 GWPDtNADDFKRYYPTNALVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEY 538
Cdd:PRK13208 473 GWER-DEDLFEKVFPMDLRPQGHDIIRTWLFYTILRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKY 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 539 GADSLRYFLAtGSSPGHDLRYSTEKVESVWNFINKIWNAARFSLMnIGEDFKVEDIDlsgNLSLADQWILTRLNETISTV 618
Cdd:PRK13208 552 GADAVRYWAA-SARLGSDTPFDEKQVKIGRRLLTKLWNASRFVLH-FSADPEPDKAE---VLEPLDRWILAKLAKVVEKA 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 619 TELSEKYEFGEVGRALYNFIWDEFCDWYIEMSK-IPMNGEDESQKQTTRSVLSYVLDKIMKMLHPFMPFVTETIWQSLph 697
Cdd:PRK13208 627 TEALENYDFAKALEEIESFFWHVFCDDYLELVKsRAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWL-- 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 698 HGETIVKASWPTVDQALIFNESKQTMEQLVEIIKSVR----QSRVEVNTPLSKAIpILIQTKDEKIKQTLMDnisyLHKF 773
Cdd:PRK13208 705 YGGSVHRASWPEPDEELIDEEDEELGELAKEILSAVRkyksEAGLSLNAPLKKVE-VYGPADLELLEAAEED----LKAA 779
|
810 820
....*....|....*....|.
gi 394254284 774 CNPSQLTI---DTEIEIPEKA 791
Cdd:PRK13208 780 GNIEELELvegDPELEVEIIA 800
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
35-559 |
0e+00 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 545.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 35 EAYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKVEAKLNEQGISRHDLGREKFLQQ 114
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTRHDLGREEFLEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 115 AWDWKEEYATFIRQQWAKLGLGLDYSRERFTLDDGLSKAVRKVFVDLYNKGIIYRGERIINWDPKARTALSDIEVihedv 194
Cdd:cd00817 81 CWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 195 qgafyhfkypyadgngyieiattrpetmlgdtaivvnpnderykdvigktvilpivgrelpiladeyvdiefgsgamkvt 274
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 275 pahdpndfeigqrhqleniivmdeygkmnekadkykgmdrfdcrnqlvkdlkeqdlvikieehthsvghSERSGAIVEPY 354
Cdd:cd00817 156 ---------------------------------------------------------------------CSRSGDVIEPL 166
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 355 LSTQWFVKMKPLAQRALDNQNtKDRIDFFPGRFENTFNRWMEEIRDWTISRQLWWGHQIPAWYHKDTGEVFVGEEAPEDI 434
Cdd:cd00817 167 LKPQWFVKVKDLAKKALEAVK-EGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAWYCKDGGHWVVAREEDEAI 245
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 435 -------------ENWIQDEDVLDTWFSSALWPFSTLGWPDtNADDFKRYYPTNALVTGYDIIFFWVARMIFQGLEFTDR 501
Cdd:cd00817 246 dkaapeacvpcggEELKQDEDVLDTWFSSSLWPFSTLGWPE-ETKDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKLTGK 324
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 394254284 502 RPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRY 559
Cdd:cd00817 325 LPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLASAATQGRDINL 382
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
6-802 |
3.35e-133 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 421.41 E-value: 3.35e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 6 KYDPREVEKGRYEEWVSNGYFKPSEDKSK--EAYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMD- 82
Cdd:COG0060 15 RANLPKREPEILKFWEENDIYEKSREARAgrPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDc 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 83 HaGIATQAKVEAKLNEQGISRHDLGREKF--------LQQAWDWKEEyatFIRqqwakLGLGLDYSRERFTLDDGLSKAV 154
Cdd:COG0060 95 H-GLPIELKVEKELGIKKKDIEKVGIAEFrekcreyaLKYVDEQRED---FKR-----LGVWGDWDNPYLTMDPEYEESI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 155 RKVFVDLYNKGIIYRGERIINWDPKARTALSDIEVIHEDVQ--GAFYHFK-----YPYADGNGYIEIATTRPETMLGDTA 227
Cdd:COG0060 166 WWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVTspSIYVKFPvkdekALLLLEDAYLVIWTTTPWTLPANLA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 228 IVVNP----------NDERY-------KDVIGK------TVILPIVGREL-------------------PILADEYVDIE 265
Cdd:COG0060 246 VAVHPdidyvlvevtGGERLilaealvEAVLKElgiedyEVLATFKGAELeglryehpfyyvvgydrahPVILGDYVTTE 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 266 FGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDEYGKMNEKADKYKGMDRFDCRNQLVKDLKEQDLVIKIEEHTHSVGHSE 345
Cdd:COG0060 326 DGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITHSYPHCW 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 346 RSGAiveP--YLST-QWFVKMKPLAQRALDNqNtkDRIDFFP----GRFENtfnrWMEEIRDWTISRQLWWGHQIPAWYH 418
Cdd:COG0060 406 RCKT---PliYRATpQWFISMDKLRDRALEA-I--EKVNWIPewgeGRFGN----MLENRPDWCISRQRYWGVPIPIWVC 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 419 KDTGEVFV---------------GEEAPEDI---ENWIQDE--------------DVLDTWFSSALWPFSTLgwpdTNAD 466
Cdd:COG0060 476 EDCGELHRteevigsvaelleeeGADAWFELdlhRPFLDETlkcpkcggtmrrvpDVLDVWFDSGSMHFAVL----ENRE 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 467 DFKryYPtnalvtgYDII----------FF---WVARMIFqgleftDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMD 533
Cdd:COG0060 552 ELH--FP-------ADFYlegsdqtrgwFYsslLTSTALF------GRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQE 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 534 VIDEYGADSLRYFLATgSSPGHDLRYSTEKVESVWNFINKIWNAARFSLMNI-GEDFKVEDIDLSGNLSLaDQWILTRLN 612
Cdd:COG0060 617 VIDKYGADILRLWVAS-SDYWGDLRFSDEILKEVRDVYRRLRNTYRFLLANLdDFDPAEDAVPYEDLPEL-DRWILSRLN 694
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 613 ETISTVTELSEKYEFGEVGRALYNFIWDEFCDWYIEMSK----IpmNGEDESQKQTTRSVLSYVLDKIMKMLHPFMPFVT 688
Cdd:COG0060 695 ELIKEVTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKdrlyT--EAADSLDRRAAQTTLYEVLETLVRLLAPILPFTA 772
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 689 ETIWQSLPH-HGETIVKASWPTVDQALIFNESKQTMEQLVEIIKSVRQS----RVE--VNTPLSkAIPILiqTKDEKIKQ 761
Cdd:COG0060 773 EEIWQNLPGeAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLKAleaaRKEklIRQPLE-AAVVL--YADEELAA 849
|
890 900 910 920
....*....|....*....|....*....|....*....|..
gi 394254284 762 TLMDNISYLHKFCNPSQLTI-DTEIEIPEKAMTSVVVAGKVV 802
Cdd:COG0060 850 ALESLGDLLAEELNVSEVELvDDAEDLGKDALKALDVEGISV 891
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
10-747 |
5.65e-75 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 264.33 E-value: 5.65e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 10 REVEKGRYeeWVSNGYFKP-SEDKSKEAYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIAT 88
Cdd:PLN02843 8 REPEIQKL--WEENQVYKRvSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 89 QAKVEAKLNEQgiSRHDLGREKFLQQAWDWKEEYATFIRQQWAKLGLGLDYSRERFTLDDGLSKAVRKVFVDLYNKGIIY 168
Cdd:PLN02843 86 ELKVLQSLDQE--ARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIY 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 169 RGERIINWDPKARTALSDIEV------IHEDVQGAFYHFKYPYADG--------NGYIEIATTRPETMLGDTAIVVNP-- 232
Cdd:PLN02843 164 RGRKPVHWSPSSRTALAEAELeypeghVSKSIYVAFPVVSPSETSPeeleeflpGLSLAIWTTTPWTMPANAAVAVNDkl 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 233 -----------NDERYKD-------------------------------------VIGKTV----------ILPIVGREL 254
Cdd:PLN02843 244 qysvvevqsfsEDESTSGgnkkkrpgnvlkeqqklflivatdlvpaleakwgvklVVLKTFpgsdlegcryIHPLYNRES 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 255 PILAD-EYVDIEFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDEYGKMNEKADKYKGMDRFDCRNQLV-KDLKEQDLVI 332
Cdd:PLN02843 324 PVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLSVLGEGNAAVvEALDEAGSLL 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 333 KIEEHTHSVGHSERSGaivEPYL---STQWFVKMKPLAQRALDnqnTKDRIDFFPGRFENTFnRWMEEIR-DWTISRQLW 408
Cdd:PLN02843 404 MEEAYGHKYPYDWRTK---KPTIfraTEQWFASVEGFRQAALD---AIDKVKWIPAQGENRI-RAMVSGRsDWCISRQRT 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 409 WGHQIPAWYHKDTGEVFVGEEAPEDIE-----------------------------NWIQDEDVLDTWFSSAlwpfSTlg 459
Cdd:PLN02843 477 WGVPIPVFYHVETKEPLMNEETIAHVKsivaqkgsdawwymdvedllpekyrdkasDYEKGTDTMDVWFDSG----SS-- 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 460 WPDTNADDFKRYYPTNALVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVID--- 536
Cdd:PLN02843 551 WAGVLGSREGLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEggk 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 537 ------EYGADSLRYFLATGSSPGhDLRYSTEKVESVWNFINKIWNAARFSLMNIGeDFKVEDIDLSGNLSLADQWILTR 610
Cdd:PLN02843 631 nqkqepAYGADVLRLWVASVDYTG-DVLIGPQILKQMSDIYRKLRGTLRYLLGNLH-DWKPDNAVPYEDLPSIDKYALFQ 708
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 611 LNETISTVTELSEKYEFGEVGRALYNFIWDEFCDWYIEMSK--IPMNGEDESQKQTTRSVLSYVLDKIMKMLHPFMPFVT 688
Cdd:PLN02843 709 LENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKdrLYVGGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLA 788
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 394254284 689 ETIWQSLPHH-----GETIVKASWPTVdqalifNESKQTM-EQLVEIIKSVRQSRVEVNTPLSKA 747
Cdd:PLN02843 789 EDAWQNLPFQedgsaAESVFEAGWPTP------NEEWLSFpAEDVDFWSLLLEVRDEVNKVLESA 847
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
37-558 |
4.85e-71 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 236.93 E-value: 4.85e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 37 YTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKVEAKLNEQGISRHdlgREKFLQQAW 116
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIW---IEEFREDPK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 117 DWKEEYATFIRQQWAKLGLGLDYSRERFTLDDGLSKAVRKVFVDLYNKGIIYRGERiinwdpkartalsdievihedvqg 196
Cdd:cd00668 79 EFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTH------------------------ 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 197 afyhfkypyadgngyieiattrpetmlgdtaivvnpnderykdvigktvilpivgrelpiladeyvdiefgsgamkvtpa 276
Cdd:cd00668 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 277 hdpndfeigqrhqleniivmdeygkmnekadkykgmdrfdcrnqlvkdlkeqdLVIKIEehthsvghsersgaivepyls 356
Cdd:cd00668 135 -----------------------------------------------------PVRITE--------------------- 140
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 357 tQWFVKMKPLAQRALDNQntkDRIDFFPGRFENTFNRWMEEIRDWTISRQLWWGHQIPawyhkdtgevfvgeeapedien 436
Cdd:cd00668 141 -QWFFDMPKFKEKLLKAL---RRGKIVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP---------------------- 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 437 wiqdEDVLDTWFSSALWPFSTLGWPDTNADdFKRYYPTNALVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAE 516
Cdd:cd00668 195 ----EDVFDVWFDSGIGPLGSLGYPEEKEW-FKDSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDE 269
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 394254284 517 DGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLR 558
Cdd:cd00668 270 GGQKMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDIR 311
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
559-695 |
8.27e-66 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 215.88 E-value: 8.27e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 559 YSTEKVESVWNFINKIWNAARFSLMNIGEDFkvEDIDLSGNLSLADQWILTRLNETISTVTELSEKYEFGEVGRALYNFI 638
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNLEDDD--EPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFF 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 394254284 639 WDEFCDWYIEMSKIPMNGEDESQKQTTRSVLSYVLDKIMKMLHPFMPFVTETIWQSL 695
Cdd:cd07962 79 WNDFCDWYLELVKPRLYGEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
9-744 |
8.26e-64 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 233.85 E-value: 8.26e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 9 PREVEKgRYEEWVSNGYFKP--SEDKSKEAYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGI 86
Cdd:PLN02882 11 PKQEEK-ILSLWSEIDAFKTqlKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 87 ATQAKVEAKLNEQGisrhdlgREKFLQQAWD-WKEEYATFIR---QQWAK----LGLGLDYSRERFTLDDGLSKAVRKVF 158
Cdd:PLN02882 90 PVEYEIDKKLGIKR-------RDDVLKMGIDkYNEECRSIVTrysKEWEKtvtrTGRWIDFENDYKTMDPKFMESVWWVF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 159 VDLYNKGIIYRGERIINWDPKARTALSDIEV--IHEDVQGAFYHFKYPYADGN-GYIEIA-TTRPETMLGDTAIVVNPND 234
Cdd:PLN02882 163 KQLFEKGLVYKGFKVMPYSTACKTPLSNFEAglNYKDVSDPAVMVSFPIVGDPdNASFVAwTTTPWTLPSNLALCVNPNF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 235 E----RYKDViGKTVI--------LP------------------------IVGREL------PI--------------LA 258
Cdd:PLN02882 243 TyvkvRNKYT-GKVYIvaesrlsaLPtakpkskkgskpenaaegyevlakVPGSSLvgkkyePLfdyfsefsdtafrvVA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 259 DEYVDIEFGSGAMKVTPAHDPNDFEIGQRHQL----ENIIV-MDEYGKMNEKADKYKGMDRFDCRNQLVKDLKEQDLVIK 333
Cdd:PLN02882 322 DDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIiekgGNLPVpVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVK 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 334 IEEHTHSVGHSERSGA--IVEPYLStqWFVKMKPLAQRALDNqNTKDRidFFP-----GRFENtfnrWMEEIRDWTISRQ 406
Cdd:PLN02882 402 SGSITHSYPFCWRSDTplIYRAVPS--WFVKVEEIKDRLLEN-NKQTY--WVPdyvkeKRFHN----WLENARDWAVSRS 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 407 LWWGHQIPAWYHKDTGEVFV-----------GEEApEDIENWIQD------------------EDVLDTWFSSALWPFST 457
Cdd:PLN02882 473 RFWGTPLPIWISDDGEEVVVigsiaeleklsGVKV-TDLHRHFIDhitipssrgpefgvlrrvDDVFDCWFESGSMPYAY 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 458 LGWPDTNADDFKRYYPTNALVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDE 537
Cdd:PLN02882 552 IHYPFENKELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDK 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 538 YGADSLRYFLAtgSSP---GHDLRYSTEKVESVWNFINKIW-NAARFSLMNI-------GEDFKVEDID-LSGNLSLADQ 605
Cdd:PLN02882 632 YGADALRLYLI--NSPvvrAEPLRFKEEGVFGVVKDVFLPWyNAYRFLVQNAkrlevegGAPFVPLDLAkLQNSANVLDR 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 606 WILTRLNETISTVTELSEKYEFGEVGRALYNFIwDEFCDWYIEMSKIPM---NGEDESqkQTTRSVLSYVLDKIMKMLHP 682
Cdd:PLN02882 710 WINSATQSLVKFVREEMGAYRLYTVVPYLVKFI-DNLTNIYVRFNRKRLkgrTGEEDC--RTALSTLYNVLLTSCKVMAP 786
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 394254284 683 FMPFVTETIWQSL----PHHGETIVKASWPTVDQALIFNESKQTMEQLVEIIKSVRQSRVEVNTPL 744
Cdd:PLN02882 787 FTPFFTEVLYQNLrkvlPGSEESIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPL 852
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
50-872 |
2.74e-59 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 218.20 E-value: 2.74e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 50 LHLGHAWDTTLQDIITRMKRMQGYDTLYlPGMDHA------GIATQ-AKVEAKL-----NEQGISRHDLgrEKFlQQAWD 117
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLF-PMAFHVtgtpilGIAERiARGDPETielykSLYGIPEEEL--EKF-KDPEY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 118 WKEEYATFIRQQWAKLGLGLDYSRERFTLDDGLSKAVRKVFVDLYNKGIIYRGERIINWDPKARTALSDIEVIH-EDVQG 196
Cdd:PRK12300 77 IVEYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDgEEPEI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 197 AFYHFKYPYADGNGYIEIATTRPETMLGDTAIVVNPN---------DERY-------------------------KDVIG 242
Cdd:PRK12300 157 VEYTLIKFEESEDLILPAATLRPETIFGVTNLWVNPDatyvkaevdGEKWivskeaaeklsfqdrdveiieeikgSELIG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 243 KTVILPIVGRELPILADEYVDIEFGSG-AMKVtPAHDPNDF---------------------------------EIGQRH 288
Cdd:PRK12300 237 KKVKNPVTGKEVPILPADFVDPDNGTGvVMSV-PAHAPYDYvalrdlkknkelldviepiplievegygefpakEVVEKL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 289 QLEN-----------IIVMDEY--GKMNEKADKYKGMDRFDCRNQLVKDLKEQDLVIKIEEHthsvghSE-----RSGA- 349
Cdd:PRK12300 316 GIKSqedpeleeatkEVYRAEFhkGVLKENTGEYAGKPVREAREKITKDLIEKGIADIMYEF------SNrpvycRCGTe 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 350 IVEPYLSTQWFVK-----MKPLAQRALDNqntkdrIDFFPGRFENTFNRWMEEIRDWTISRQLWWGHQIP---------- 414
Cdd:PRK12300 390 CVVKVVKDQWFIDysdpeWKELAHKALDN------MEIIPEEYRKEFENTIDWLKDRACARRRGLGTRLPwdeewiiesl 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 415 -------AWY--------HKDTGE---------VFVGEEAPEDI--ENWIQDEDVldtwfssalwpfstlgwpDTNADDF 468
Cdd:PRK12300 464 sdstiymAYYtiahkireYGIKPEqltpeffdyVFLGKGDPEEVskKTGIPKEIL------------------EEMREEF 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 469 KRYYPTNALVTGYDII-----FFW---VArmIFqGLEFTDRRpfndVLLHGLVRAEdGRKMSKSLGNGVDPMDVIDEYGA 540
Cdd:PRK12300 526 LYWYPVDWRHSGKDLIpnhltFFIfnhVA--IF-PEEKWPRG----IVVNGFVLLE-GKKMSKSKGNVIPLRKAIEEYGA 597
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 541 DSLRYFLATGSSPGHDLRYSTEKVESVWNFINKIWNAARfslmnigedfKVEDIDLSGNLSLADQWILTRLNETISTVTE 620
Cdd:PRK12300 598 DVVRLYLTSSAELLQDADWREKEVESVRRQLERFYELAK----------ELIEIGGEEELRFIDKWLLSRLNRIIKETTE 667
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 621 LSEKYEFGE-VGRALYNFIWDefCDWYIEMSKIPmngedesqkqtTRSVLSYVLDKIMKMLHPFMPFVTETIWQSLPHHG 699
Cdd:PRK12300 668 AMESFQTRDaVQEAFYELLND--LRWYLRRVGEA-----------NNKVLREVLEIWIRLLAPFTPHLAEELWHKLGGEG 734
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 700 eTIVKASWPTVDQALIFNESKQTMEQLVEIIKSVRQsrvevntplskaIPILIQTKDEKIKQTLMDNISYlhkfcnpSQL 779
Cdd:PRK12300 735 -FVSLEKWPEPDESKIDEEAELAEEYVKRLIEDIRE------------ILKVAKIKPKKVYIYVAPDWKY-------EVL 794
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 780 TIDTEIEIPEKAMtsvvvagKVVLPLEGLIDMDKEIARLEKELDKLQSELDRVDKKLSNENFvnkAPEKIINEEKEkqqh 859
Cdd:PRK12300 795 EIAAENGDVKEAI-------KELMKDEELRKHGKEVAKLAQKIVKEVLKLDKEVRKLILKNI---DEEEVLEEAKD---- 860
|
970
....*....|...
gi 394254284 860 YQEKYNGVKSRIE 872
Cdd:PRK12300 861 FLEKELGVEVEIY 873
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
3-715 |
1.44e-56 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 209.14 E-value: 1.44e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 3 MKPKYDPREVEKGRYEEWVSNGYFKPSEDKSKEAYTIVI--PPPnvTGKLHLGHAWDTTLQDIITRMKRMQGYDTLY--- 77
Cdd:COG0495 1 MQERYNPKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDmfPYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVLHpmg 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 78 -----LPgmdhagiATQAKVE-----AKLNEQGIsrhdlgrekflqqawdwkeeyATFiRQQWAKLGLGLDYSRE----- 142
Cdd:COG0495 79 wdafgLP-------AENAAIKngvhpAEWTYENI---------------------ANM-RRQLKRLGLSYDWSREiatcd 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 143 ----RFTlddglskavRKVFVDLYNKGIIYRGERIINWDPKARTALSDIEVIH--------------------------- 191
Cdd:COG0495 130 peyyKWT---------QWIFLQLYEKGLAYRKEAPVNWCPVDQTVLANEQVIDgrcwrcgapvekkelpqwflkitdyad 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 192 -------------EDV-----------QGAfyHFKYPYADGNGYIEIATTRPETMLGDTAIVVNP-------------ND 234
Cdd:COG0495 201 ellddldkldgwpEKVktmqrnwigrsEGA--EVDFPVEGSDEKITVFTTRPDTLFGATFMVLAPehplvkelatpeqNA 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 235 E--------RYKDVI--------------GKTVILPIVGRELPILADEYVDIEFGSGA-MKVtPAHDPNDFEIGQRHQLE 291
Cdd:COG0495 279 AvaafieeaKKKSEIertsetkektgvftGLYAINPLTGEKIPIWIADYVLMDYGTGAvMAV-PAHDQRDFEFAKKYGLP 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 292 NIIVMD---------------EYGKM-NekADKYKGMDRFDCRNQLVKDLKEQDLvikieehthsvghsersgaivepyl 355
Cdd:COG0495 358 IKQVIApedgddpdileeaytGDGVLiN--SGEFDGLDSEEAKEAIIEWLEEKGL------------------------- 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 356 stqwfvkmkplaqraldnqntkdridffpGRFENTFnRwmeeIRDWTISRQLWWGHQIPAWYHKDTGEVFVGEEA----- 430
Cdd:COG0495 411 -----------------------------GKRKVNY-R----LRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQlpvel 456
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 431 PED-------------IENWIQDE------------DVLDTWF-SSalWPFstLGWPDTNADD-------FKRYYP---- 473
Cdd:COG0495 457 PEDvdfdptggsplarAPEWVNVTcpkcggparretDTMDTFVdSS--WYY--LRYTDPHNDEapfdpeaANYWLPvdqy 532
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 474 -----------------TNALvtgYDIiffwvarmifqGLEFTDRrPFNDVLLHGLVR--AEDGR------KMSKSLGNG 528
Cdd:COG0495 533 iggiehailhllyarffTKVL---RDL-----------GLVSFDE-PFKRLLTQGMVLevGKDGVviggieKMSKSKGNV 597
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 529 VDPMDVIDEYGADSLRYFLATGSSPGHDLRYSTEKVESVWNFINKIWNAArfslMNIGEDFKVEDIDLSGnlslADQWIL 608
Cdd:COG0495 598 VDPDEIIEKYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRLV----VDEAEALKLDVADLSE----ADKELR 669
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 609 TRLNETISTVTELSEKYEFGEVGRALYnfiwdEFCDwyiEMSKIPMNGEDEsqkqttRSVLSYVLDKIMKMLHPFMPFVT 688
Cdd:COG0495 670 RALHKTIKKVTEDIERLRFNTAIAALM-----ELVN---ALYKAKDSGEAD------RAVLREALETLVLLLAPFAPHIA 735
|
890 900
....*....|....*....|....*..
gi 394254284 689 ETIWQSLpHHGETIVKASWPTVDQALI 715
Cdd:COG0495 736 EELWERL-GHEGSVADAPWPEADEAAL 761
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
43-559 |
9.58e-54 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 190.14 E-value: 9.58e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 43 PPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKVEAKLNEQGIS-RHDLGREKFLQQAWDWKEE 121
Cdd:cd00818 9 PPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKdIEKMGIAEFNAKCREFALR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 122 YATFIRQQWAKLGLGLDYSRERFTLDDGLSKAVRKVFVDLYNKGIIYRGERIINWdpkartalsdievihedvqgafyhf 201
Cdd:cd00818 89 YVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW------------------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 202 kypyadgngyieiattrpetmlgdtaivvnpnderykdvigktvilPIVGRELPiladeyvdiefgsgamkvtpahdpnd 281
Cdd:cd00818 144 ----------------------------------------------PLIYRATP-------------------------- 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 282 feigqrhqleniivmdeygkmnekadkykgmdrfdcrnqlvkdlkeqdlvikieehthsvghsersgaivepylstQWFV 361
Cdd:cd00818 152 ----------------------------------------------------------------------------QWFI 155
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 362 KMKPLAQRALDNQntkDRIDFFPGRFENTFNRWMEEIRDWTISRQLWWGHQIPAWYHKDTGEVFVgeeapedienwIQDE 441
Cdd:cd00818 156 RVTKIKDRLLEAN---DKVNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLV-----------RRVP 221
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 442 DVLDTWFSSALWPFSTLGWPDTNaDDFKRYYPTNALVTGYDIIFFWvarmiFQGLEFT-----DRRPFNDVLLHGLVRAE 516
Cdd:cd00818 222 DVLDVWFDSGSMPYAQLHYPFEN-EDFEELFPADFILEGSDQTRGW-----FYSLLLLstalfGKAPYKNVIVHGFVLDE 295
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 394254284 517 DGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRY 559
Cdd:cd00818 296 DGRKMSKSLGNYVDPQEVVDKYGADALRLWVASSDVYAEDLRF 338
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
20-695 |
3.17e-46 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 179.78 E-value: 3.17e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 20 WVSNGYFKPSED--KSKEAYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKVEaklN 97
Cdd:PTZ00427 85 WKSIDAFNTSNKlaKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEYEIE---K 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 98 EQGISRhdlgREKFLQQAWDWKEEYATFI----RQQWAK----LGLGLDYSRERFTLDDGLSKAVRKVFVDLYNKGIIYR 169
Cdd:PTZ00427 162 ENNINK----KEDILKMGIDVYNEKCRGIvlkySNEWVKtverIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYK 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 170 GERIINWDPKARTALSDIEV------------------------------IHEDVQGAFYHFKYPYADGN---------- 209
Cdd:PTZ00427 238 SFKVMPYSCKCNTPISNFELnlnykdtpdpsiiisfvlcsdfpkveeecnIEEDKQLLGEKYSVLYNNKRensnngnnns 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 210 -------GYIEIA--TTRPETMLGDTAIVVNPN--------------------------DERYKDVIGKTVILPIVGREL 254
Cdd:PTZ00427 318 tnnvcyaQHSEILawTTTPWTLPSNLALCVNEHftylrihhvksnrvvivgecrlewimKELKWNVEDLKIVNRFKGKEL 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 255 P-----------------------ILADEYVDIEFGSGAMKVTPAHDPNDFEIGQRHQL----ENIIV--MDEYGKMNEK 305
Cdd:PTZ00427 398 KglrykplftnfyekynfkeraykILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidpeKNIFIdpLDANGYFTNE 477
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 306 ADKYKGMDRFDCRNQLVKDLKEQDLVIKIEEHTHSVGHSERSGAIVEPYLSTQWFVKMKPLAQRALDNQNTKDRIdffPG 385
Cdd:PTZ00427 478 VEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNNETTYWI---PA 554
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 386 RF-ENTFNRWMEEIRDWTISRQLWWGHQIPAWYHKDTGEVFVGEEAPE---------------------DIENWIQDE-- 441
Cdd:PTZ00427 555 HIkEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKHleelsgvknindlhrhfidhiEIKNPKGKTyp 634
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 442 ------DVLDTWFSSALWPFSTLGWP-DTNADDFKRYYPTNALVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVR 514
Cdd:PTZ00427 635 klkripEVFDCWFESGSMPYAKVHYPfSTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVL 714
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 515 AEDGRKMSKSLGNGVDPMDVIDEYGADSLR-YFLATGSSPGHDLRYSTEKV-ESVWNFINKIWNAARFSLMNI------- 585
Cdd:PTZ00427 715 ASDGKKMSKRLKNYPDPLYILDKYGADSLRlYLINSVAVRAENLKFQEKGVnEVVKSFILPFYHSFRFFSQEVtryecln 794
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 586 GEDFKVEDIDLSGNLSLADQWILTRLNETISTVTELSEKYEFGEVGRALYNFIwDEFCDWYIEMSKIPMNG----EDESQ 661
Cdd:PTZ00427 795 KKQFLFNTDYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFI-ENLTNWYIRLNRDRMRGslgeENCLQ 873
|
810 820 830
....*....|....*....|....*....|....
gi 394254284 662 KQTTRSVLSYVLDKIMKmlhPFMPFVTETIWQSL 695
Cdd:PTZ00427 874 SLCTTYRTLHLFTVLMA---PFTPFITEYIYQQL 904
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
604-752 |
5.62e-42 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 149.86 E-value: 5.62e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 604 DQWILTRLNETISTVTELSEKYEFGEVGRALYNFIWDEFCDWYIEMSKIPMNGEDESQKqtTRSVLSYVLDKIMKMLHPF 683
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSR--AQTTLYEVLETLLRLLAPF 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 394254284 684 MPFVTETIWQSlphhgETIVKASWPTVDQALIfNESKQTMEQLVEIIKSVRQSRVEVNTPLSKAIPILI 752
Cdd:pfam08264 79 MPFITEELWQK-----ESIHLAPWPEDAELEE-AELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
11-763 |
1.40e-36 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 148.82 E-value: 1.40e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 11 EVEKGRYEEWVSNGYFK-PSE-DKSKEAYTIV--IPPPNVTGkLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGI 86
Cdd:PLN02563 84 EIEPKWQRYWEENRTFRtPDDvDTSKPKFYVLdmFPYPSGAG-LHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 87 -ATQAKVEAKLNEQGISRHDLGRekflqqawdwkeeyatfIRQQWAKLGLGLDYSRERFTLDDGLSKAVRKVFVDLYNKG 165
Cdd:PLN02563 163 pAEQYAIETGTHPKITTLKNIAR-----------------FRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRG 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 166 IIYRGERIINWDPKARTALSDIEVIH------------------------------EDV--------------------Q 195
Cdd:PLN02563 226 LAYQAEVPVNWCPALGTVLANEEVVDglsergghpvirkpmrqwmlkitayadrllEDLddldwpesikemqrnwigrsE 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 196 GAFYHFKYPyaDGNGY-----IEIATTRPETMLGDTAIVVNP---------------NDERYKDV--------------- 240
Cdd:PLN02563 306 GAELDFSVL--DGEGKerdekITVYTTRPDTLFGATYLVVAPehpllsslttaeqkeAVEEYVDAasrksdlertelqke 383
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 241 -----IGKTVILPIVGRELPILADEYVDIEFGSGAMKVTPAHDPNDFEIGQRHQLENI-IVMDEYGKMNEKADKYKGmdr 314
Cdd:PLN02563 384 ktgvfTGSYAINPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKwVVKPADGNEDDAEKAYTG--- 460
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 315 fdcrnqlvkdlkeqdlvikieehtHSVGHSERSGAIVEPYLSTQwfVKMKPLAQRALDNQNTKDRIDFfpgrfentfnrw 394
Cdd:PLN02563 461 ------------------------EGVIVNSSSSGLDINGLSSK--EAAKKVIEWLEETGNGKKKVNY------------ 502
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 395 meEIRDWTISRQLWWGHQIPAWYHKDTGE-VFVGE-----EAPE---------------DIENWIQDEDVLD-------- 445
Cdd:PLN02563 503 --KLRDWLFARQRYWGEPIPVVFLEDSGEpVPVPEsdlplTLPElddftptgtgepplaKAVSWVNTVDPSSgkparret 580
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 446 ----TWFSSALWPFSTLGWPDTNA---DDFKRYY-PTNALVTGYD-----IIF--FW---------------VARMIFQG 495
Cdd:PLN02563 581 ntmpQWAGSCWYYLRFMDPKNSNAlvdKEKEKYWmPVDLYVGGAEhavlhLLYarFWhkvlydigvvstkepFQCLVNQG 660
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 496 L-----EFTDRR-----------------------PFNDVLLHG--LVRAEDGR--------KMSKSLGNGVDPMDVIDE 537
Cdd:PLN02563 661 MilgevEYTAFKdsdgeyvsadtadrlgelqqekiPEEKVIKSGdsFVLKDDPSirliarahKMSKSRGNVVNPDDVVSE 740
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 538 YGADSLR-YFLATGssPGHDLR-YSTEKVESVWNFINKIWNAARFSLMNIGEdFKVEDIDLSGNLSLADqwiLTRLNETI 615
Cdd:PLN02563 741 YGADSLRlYEMFMG--PLRDSKtWSTSGVEGVHRFLGRTWRLVVGAPLPDGS-FRDGTVVTDEEPSLEQ---LRLLHKCI 814
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 616 STVTELSEKYEFGEVGRALYNFI-----WDefcdwyiemsKIPmngedesqkqttRSVL-SYVLdkimkMLHPFMPFVTE 689
Cdd:PLN02563 815 AKVTEEIESTRFNTAISAMMEFTnaaykWD----------KVP------------REAIePFVL-----LLSPYAPHLAE 867
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 394254284 690 TIWQSLPHHGeTIVKASWPTVDQALIfNESKQTMEqlVEIIKSVRqSRVEVNTPLSKAIPILIQTKDEKIKQTL 763
Cdd:PLN02563 868 ELWFRLGHSN-SLAYEPWPEANPSYL-VDDTVVLP--VQINGKTR-GTIEVEEGCSEDDAFALASQDEKLSKYL 936
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
41-714 |
2.17e-34 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 139.09 E-value: 2.17e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 41 IPPPNvtGKLHLGHAWdTTLQ-DIITRMKRMQGYDTLYLPGMD-HagiatQAKVEAKLNEQGISRHDLGrekflqqawdw 118
Cdd:COG0143 9 IPYAN--GPPHIGHLY-TYIPaDILARYQRLRGHDVLFVTGTDeH-----GTKIELAAEKEGITPQELV----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 119 kEEYATFIRQQWAKLGLGLD-YSRerfTLDDGLSKAVRKVFVDLYNKGIIYRGEriinwdpkartalsdIEVIHEDVQGA 197
Cdd:COG0143 70 -DRIHAEFKELFEKLGISFDnFIR---TTSPEHKELVQEIFQRLYDNGDIYKGE---------------YEGWYCPECER 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 198 FYHfkypyadgngyieiattrpetmlgdtaivvnpndERYkdVIGKTvilPIVGRElpiladeyvdiefgsgamkvtpah 277
Cdd:COG0143 131 FLP----------------------------------DRY--VEGTC---PKCGAE------------------------ 147
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 278 dpndfeigqrhqleniivmDEYGKMNEKadkykgmdrfdCRNQLV-KDLKEQDLVIkieehthsvghserSGAIVEPYLS 356
Cdd:COG0143 148 -------------------DAYGDQCEN-----------CGATLEpTELINPRSAI--------------SGAPPELREE 183
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 357 TQWFVKMKPLAQRALDNqnTKDRIDFFPGRFeNTFNRWMEE-IRDWTISRQLWWGHQIPAwyhkDTGEVF-Vgeeapedi 434
Cdd:COG0143 184 EHYFFRLSKYQDRLLEW--IEENPDIQPEVR-NEVLSWLKEgLQDLSISRDFDWGIPVPG----DPGKVFyV-------- 248
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 435 enwiqdedvldtWFsSALWPF--STLGWPD--TNADDFKRYYP-TNALVT---GYDIIFF----WVArMifqgLEFTDRR 502
Cdd:COG0143 249 ------------WF-DALIGYisATKGYADdrGLPEDFEKYWPaPDTELVhfiGKDIIRFhaiiWPA-M----LMAAGLP 310
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 503 PFNDVLLHG--LVraeDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRYSTEKVESVWNF--INKIWNAA 578
Cdd:COG0143 311 LPKKVFAHGflTV---EGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQDGDFSWEDFVARVNSdlANDLGNLA 387
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 579 R--FSLMNIGEDFKVEDIdlsGNLSLADQWILTRLNETISTVTELSEKYEFGEVGRALYNFIwdEFCDWYIEMSK--IPM 654
Cdd:COG0143 388 SrtLSMIHKYFDGKVPEP---GELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMALA--RAANKYIDETApwKLA 462
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 655 NGEDESQKQTTRSVLSYVLDKIMKMLHPFMPFVTETIWQSLphhGETIVKASWPTVDQAL 714
Cdd:COG0143 463 KDEDPERLATVLYTLLEALRILAILLKPFLPETAEKILEQL---GLEGDELTWEDAGWPL 519
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
37-700 |
1.33e-32 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 133.08 E-value: 1.33e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 37 YTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMD-HagiatQAKVEAKLNEQGISRHDLGREkflqqa 115
Cdd:PRK11893 3 FYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDeH-----GQKIQRKAEEAGISPQELADR------ 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 116 wdwkeeYATFIRQQWAKLglglDYSRERF--TLDDGLSKAVRKVFVDLYNKGIIYRGEriinwdpkartalsdievihed 193
Cdd:PRK11893 72 ------NSAAFKRLWEAL----NISYDDFirTTDPRHKEAVQEIFQRLLANGDIYLGK---------------------- 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 194 VQGafyhfkyPYAdgngyieiattrpetmlgdtaivvnPNDERYK---DVIGKTVILPIVGRELpiladEYVDIE--Fgs 268
Cdd:PRK11893 120 YEG-------WYC-------------------------VRCEEFYtesELIEDGYRCPPTGAPV-----EWVEEEsyF-- 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 269 gamkvtpahdpndFEIGqrhqleniivmdeygkmnekadkykgmdrfdcrnqlvkdlKEQDlviKIEEHthsvghsersg 348
Cdd:PRK11893 161 -------------FRLS----------------------------------------KYQD---KLLEL----------- 173
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 349 aivepYLSTQWFVKMKplaqraldnqntkdridffpGRFENTFNRWMEEIRDWTISRQ-LWWGhqIPawyhkdtgevfvg 427
Cdd:PRK11893 174 -----YEANPDFIQPA--------------------SRRNEVISFVKSGLKDLSISRTnFDWG--IP------------- 213
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 428 eeapedienWIQDED-VLDTWFSsALWPF-STLGWPDTN---ADDFKRYYPTNALVTGYDIIFF----WVARMIFQGLEF 498
Cdd:PRK11893 214 ---------VPGDPKhVIYVWFD-ALTNYlTALGYPDDEellAELFNKYWPADVHLIGKDILRFhavyWPAFLMAAGLPL 283
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 499 TDRrpfndVLLHG-LVRaeDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRYSTEKVESVWN--FINKIW 575
Cdd:PRK11893 284 PKR-----VFAHGfLTL--DGEKMSKSLGNVIDPFDLVDEYGVDAVRYFLLREIPFGQDGDFSREAFINRINadLANDLG 356
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 576 NAARFSLMNIGEDFKVEdIDLSGNLSLADQWILTRLNETISTVTELSEKYEFGEVGRALYNFIwdEFCDWYIEMSKiP-- 653
Cdd:PRK11893 357 NLAQRTLSMIAKNFDGK-VPEPGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILALV--RAANKYIDEQA-Pws 432
|
650 660 670 680
....*....|....*....|....*....|....*....|....*..
gi 394254284 654 MNGEDESQKQTTRSVLSYVLDKIMKMLHPFMPFVTETIWQSLPHHGE 700
Cdd:PRK11893 433 LAKTDPERLATVLYTLLEVLRGIAVLLQPVMPELAAKILDQLGVEED 479
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
565-734 |
1.82e-29 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 115.73 E-value: 1.82e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 565 ESVWNFINKIWNAARFSLMNI---GEDFKVEDIDLSGNLSLaDQWILTRLNETISTVTELSEKYEFGEVGRALYNFIwDE 641
Cdd:cd07961 8 EVVRKVLLPLWNAYRFFVTYAnldGFDPGKDDDAVASLNVL-DRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFI-DE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 642 FCDWYIEMSKIPMNGEDESQ-KQTTRSVLSYVLDKIMKMLHPFMPFVTETIWQSL----PHHGETIVKASWPTVDQALIF 716
Cdd:cd07961 86 LTNWYIRRNRKRFWGEEGDDdKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLrrelGDAPESVHLLDWPEVDESLID 165
|
170
....*....|....*...
gi 394254284 717 NESKQTMEQLVEIIKSVR 734
Cdd:cd07961 166 EELEEAMELVREIVELGR 183
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
39-726 |
7.17e-27 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 115.94 E-value: 7.17e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 39 IVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKVEAklneQGISRhdlgrEKFLqqawdw 118
Cdd:TIGR00398 3 ITTALPYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQ----EGLTP-----KELV------ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 119 kEEYATFIRQQWAKLGLGLD-YSRerfTLDDGLSKAVRKVFVDLYNKGIIYRGEriinwdpkartalsdievihedVQGA 197
Cdd:TIGR00398 68 -DKYHEEFKDDWKWLNISFDrFIR---TTDEEHKEIVQKIFQKLKENGYIYEKE----------------------IKQL 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 198 FyhfkypyadgngyieiattrpetmlgdtaivvNPNDERYkdvigktvilpivgrelpiLADEYVDIEfgsgamkvTPAH 277
Cdd:TIGR00398 122 Y--------------------------------CPECEMF-------------------LPDRYVEGT--------CPKC 142
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 278 DPNDFEIGQRHQLEniivmdeygkmnekadkykgmdrfdcRNQLVKDLKEQDLVIkieehthsvghserSGAIVEPYLST 357
Cdd:TIGR00398 143 GSEDARGDHCEVCG--------------------------RHLEPTELINPRCKI--------------CGAKPELRDSE 182
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 358 QWFVKMKPLAQRALD-NQNTKDRIdFFPGRFENTFNRWMEE-IRDWTISRQL-WWGHQIPawyhKDTGEVFVgeeapedi 434
Cdd:TIGR00398 183 HYFFRLSAFEKELEEwIRKNPESG-SPASNVKNKAQNWLKGgLKDLAITRDLvYWGIPVP----NDPNKVVY-------- 249
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 435 enwiqdedvldTWFSSALWPFSTLGWPDTNADDFKRYYPTNALVT-----GYDIIFF----WVARMIfqGLEFtdrRPFN 505
Cdd:TIGR00398 250 -----------VWFDALIGYISSLGILSGDTEDWKKWWNNDEDAElihfiGKDIVRFhtiyWPAMLM--GLGL---PLPT 313
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 506 DVLLHGLVRAEdGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRYSTEKVESVWN--FINKIWN-AAR-FS 581
Cdd:TIGR00398 314 QVFSHGYLTVE-GGKMSKSLGNVVDPSDLLARFGADILRYYLLKERPLGKDGDFSWEDFVERVNadLANKLGNlLNRtLG 392
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 582 LMNIGEDFKVEDIDLSGNlslADQWILTRLNETISTVTELSEKYEFGEVGRALY------NFIWDEFCDWyiEMSKipmn 655
Cdd:TIGR00398 393 FIKKYFNGVLPSEDITDE---EDKKLLKLINEALEQIDEAIESFEFRKALREIMkladrgNKYIDENKPW--ELFK---- 463
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 394254284 656 gEDESQKQtTRSVLSYVLDKIMKMLHPFMPFVTETIWQSLphhGETIVKASWPTVDQALIFNESKQTMEQL 726
Cdd:TIGR00398 464 -QSPRLKE-LLAVCSMLIRVLSILLYPIMPKLSEKILKFL---NFELEWDFKLKLLEGHKLNKAEPLFSKI 529
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
37-574 |
7.92e-26 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 110.46 E-value: 7.92e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 37 YTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKVEaklnEQGISRHDLGrekflqqaw 116
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAE----KEGITPEELV--------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 117 dwkEEYATFIRQQWAKLGLGLD-YSRerfTLDDGLSKAVRKVFVDLYNKGIIYRGERIINWDPKARTALSDIEVIhedvq 195
Cdd:pfam09334 68 ---DRYHEIHREDFKKFNISFDdYGR---TTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVE----- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 196 GAFYHFKYPYADGNGYieiattrpetmlgdtaivvnpnderykDVIGKTVilpivgrelpiladeyvdiefgsgamkvtp 275
Cdd:pfam09334 137 GTCPHCGSEDARGDQC---------------------------ENCGRHL------------------------------ 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 276 ahDPNDfeigqrhqLENIIVMdeygkmnekadkykgmdrfdcrnqlvkdLKEQDLVIKIEEHthsvghsersgaivepyl 355
Cdd:pfam09334 160 --EPTE--------LINPKCV----------------------------ICGTTPEVKETEH------------------ 183
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 356 stqWFVKMKPLAQRALD--NQNTKDRidffPGRFENTFNRWMEE-IRDWTISRQLWWGHQIPAwyhkdtgevfvgeeape 432
Cdd:pfam09334 184 ---YFFDLSKFQDKLREwiEENNPEW----PENVKNMVLEWLKEgLKDRAISRDLDWGIPVPG----------------- 239
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 433 dienwiQDEDVLDTWFSSALWPFSTLGWPDTNADDFKRYYPTNALVTGY-----DIIFF----WVARMIFQGLEFTDRrp 503
Cdd:pfam09334 240 ------AEGKVFYVWLDAPIGYISATKELSGNEEKWKEWWPNDPDTELVhfigkDIIYFhtifWPAMLLGAGYRLPTT-- 311
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 394254284 504 fndVLLHGLVRAEdGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRYSTEKvesvwnFINKI 574
Cdd:pfam09334 312 ---VFAHGYLTYE-GGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDTDFSWED------FVERV 372
|
|
| Val_tRNA-synt_C |
pfam10458 |
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA ... |
810-875 |
2.19e-22 |
|
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA synthetases.
Pssm-ID: 431296 [Multi-domain] Cd Length: 66 Bit Score: 91.17 E-value: 2.19e-22
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 394254284 810 DMDKEIARLEKELDKLQSELDRVDKKLSNENFVNKAPEKIINEEKEKQQHYQEKYNGVKSRIEQLK 875
Cdd:pfam10458 1 DVEKERARLEKELAKLQKEIERVQGKLANPGFVAKAPAEVVEEEKAKLAELEEQAEKLRERLSKLG 66
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
573-741 |
4.00e-22 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 94.51 E-value: 4.00e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 573 KIWNAARFSLMNIGEDFKVEDIDLSGNLSLADQWILTRLNETISTVTELSEKYEFGEVGRALYNFIWDEFCDWYIEMSKI 652
Cdd:cd07960 15 KIRNTFRFLLGNLNDFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDLSAFYLDIIKD 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 653 PM--NGEDESQKQTTRSVLSYVLDKIMKMLHPFMPFVTETIWQSLPH--HGETIVKASWPTVDQALIFNESKQTMEQLVE 728
Cdd:cd07960 95 RLycDAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGekKEESVFLEDWPELPEEWKDEELEEKWEKLLA 174
|
170
....*....|...
gi 394254284 729 IiksvrqsRVEVN 741
Cdd:cd07960 175 L-------RDEVN 180
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
46-695 |
2.65e-21 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 99.49 E-value: 2.65e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 46 VTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGiatQaKVEAKLNEQGISrhdlgrekflQQAW-DwkeEYAT 124
Cdd:PRK12267 15 PNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHG---Q-KIQQAAEKAGKT----------PQEYvD---EISA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 125 FIRQQWAKLGLGLDYsrerF--TLDDGLSKAVRKVFVDLYNKGIIYRGEriinwdpkartalsdievihedvqgafYHFK 202
Cdd:PRK12267 78 GFKELWKKLDISYDK----FirTTDERHKKVVQKIFEKLYEQGDIYKGE---------------------------YEGW 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 203 YPYADGNGYieiattrPETMLGDtaivvnpnderykdvIGKTvilPIVGRELPILADE-YvdieFgsgamkvtpahdpnd 281
Cdd:PRK12267 127 YCVSCETFF-------TESQLVD---------------GGKC---PDCGREVELVKEEsY----F--------------- 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 282 FeigqrhqleniivmdeygKMNekadKYkgmdrfdcrnqlvkdlkeQDLVIK-IEEHthsvghsersgaivepylstqwf 360
Cdd:PRK12267 163 F------------------RMS----KY------------------QDRLLEyYEEN----------------------- 179
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 361 vkmkPlaqraldnqntkdriDF-FPGRFEN-TFNRWMEE-IRDWTISRQ-LWWGHQIPawyhKDTGEV-FVgeeapedie 435
Cdd:PRK12267 180 ----P---------------DFiQPESRKNeMINNFIKPgLEDLSISRTsFDWGIPVP----FDPKHVvYV--------- 227
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 436 nWIqdeDVLDTWFSSalwpfstLGWPDTNADDFKRYYPTNALVTGYDIIFF----WVARMIFQGLEftdrrPFNDVLLHG 511
Cdd:PRK12267 228 -WI---DALLNYITA-------LGYGSDDDELFKKFWPADVHLVGKDILRFhaiyWPIMLMALGLP-----LPKKVFAHG 291
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 512 -LVRaeDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRYSTEkvesvwNFINKIwNAarfSLMN------ 584
Cdd:PRK12267 292 wWLM--KDGKMSKSKGNVVDPEELVDRYGLDALRYYLLREVPFGSDGDFSPE------ALVERI-NS---DLANdlgnll 359
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 585 ---IGEDFKVED--IDLSGNLSLADQWILTRLNETISTVTELSEKYEFGEVGRALYNFIwdEFCDWYIEMSKiPMN-GED 658
Cdd:PRK12267 360 nrtVAMINKYFDgeIPAPGNVTEFDEELIALAEETLKNYEELMEELQFSRALEEVWKLI--SRANKYIDETA-PWVlAKD 436
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 394254284 659 ESQKQTTRSVLSYVLD---KIMKMLHPFMPFVTETIWQSL 695
Cdd:PRK12267 437 EGKKERLATVMYHLAEslrKVAVLLSPFMPETSKKIFEQL 476
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
44-559 |
5.49e-17 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 82.96 E-value: 5.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 44 PNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQakVEAKlnEQGISRHDLGrekflqqawdwkEEYA 123
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIE--QKAE--EEGVTPQELC------------DKYH 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 124 TFIRQQWAKLGLGLD-YSRerfTLDDGLSKAVRKVFVDLYNKGIIYRGEriinwdpkartalsdievihedVQGAFyhfk 202
Cdd:cd00814 73 EIFKDLFKWLNISFDyFIR---TTSPRHKEIVQEFFKKLYENGYIYEGE----------------------YEGLY---- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 203 ypyadgngyieiattrpetmlgdtaivvNPNDERYkdvigktviLPivgrelpiladeyvdiefgsgamkvtpahdpndf 282
Cdd:cd00814 124 ----------------------------CVSCERF---------LP---------------------------------- 132
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 283 eigqrhqleniivmdeygkmnekadkykgmdrfdcrnqlvkdlkeqdlVIKIEEHthsvghsersgaivepylstqWFVK 362
Cdd:cd00814 133 ------------------------------------------------EWREEEH---------------------YFFR 143
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 363 MKPLAQRALDN-QNTKDRIdfFPGRFENTFNRWMEE-IRDWTISRQLW-WGHQIPawyhKDTGEVF-VGEEAP----EDI 434
Cdd:cd00814 144 LSKFQDRLLEWlEKNPDFI--WPENARNEVLSWLKEgLKDLSITRDLFdWGIPVP----LDPGKVIyVWFDALigyiSAT 217
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 435 ENWIqDEDVLDTWFSSalwpfstlGWPdtnaddfKRYYptnalVTGYDIIFF----WVARMIFQGLEFTDRrpfndVLLH 510
Cdd:cd00814 218 GYYN-EEWGNSWWWKD--------GWP-------ELVH-----FIGKDIIRFhaiyWPAMLLGAGLPLPTR-----IVAH 271
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 394254284 511 GLVRAEdGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRY 559
Cdd:cd00814 272 GYLTVE-GKKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKDSDF 319
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
355-557 |
1.78e-16 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 81.14 E-value: 1.78e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 355 LSTQWFVKMKP--LAQRALDNQntkDRIDFFPGRFENTFNRWMEeirdwtISRQLWWGHQIPawyhkdtgevfvgeeape 432
Cdd:cd00812 128 LLDQWFLKYSEteWKEKLLKDL---EKLDGWPEEVRAMQENWIG------CSRQRYWGTPIP------------------ 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 433 dienWiqdEDVLDTWFSSALWPF-------STLGWPDTNADD---FKRYYPTNALVTGYDII--------FFWVArmIFQ 494
Cdd:cd00812 181 ----W---TDTMESLSDSTWYYArytdahnLEQPYEGDLEFDreeFEYWYPVDIYIGGKEHApnhllysrFNHKA--LFD 251
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 394254284 495 gLEFTDRRPFNDVLLHGLVRAEdGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDL 557
Cdd:cd00812 252 -EGLVTDEPPKGLIVQGMVLLE-GEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADF 312
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
562-684 |
6.40e-15 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 71.77 E-value: 6.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 562 EKVESVWNFINKIWNAARFSLMNIGEDFKVEDidlSGNLSLADQWILTRLNETISTVTELSEKYEFGEVGRALYNFIWDE 641
Cdd:cd07375 2 ERLKQARAFLNRLYRLLSFFRKALGGTQPKWD---NELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL 78
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 394254284 642 fcDWYIEMSKIPMNGEDESQKqtTRSVLSYVLDKIMKMLHPFM 684
Cdd:cd07375 79 --NWYLDELKPALQTEELREA--VLAVLRAALVVLTKLLAPFT 117
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
389-695 |
9.15e-15 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 78.65 E-value: 9.15e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 389 NTFNRWMEE-IRDWTISRQL-WWGHQIPAwyhkDTGEVF-VGEEAPedI------ENWIQDEDVLDtwfssalwpfstlg 459
Cdd:PRK00133 214 NKMKEWLEEgLQDWDISRDApYFGFEIPG----APGKVFyVWLDAP--IgyisstKNLCDKRGGLD-------------- 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 460 wpdtnaddFKRYY---PTNALV--TGYDIIF----FWVArMifqgLEFTDRRPFNDVLLHGLVRAEdGRKMSKSLGNGVD 530
Cdd:PRK00133 274 --------WDEYWkkdSDTELYhfIGKDIIYfhtlFWPA-M----LEGAGYRLPTNVFAHGFLTVE-GAKMSKSRGTFIW 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 531 PMDVIDEYGADSLRYFLATGSSPGH-DLRYS----TEKVES--VWNFINKIWNAARFslmnIGEDF--KVEDidlsgnlS 601
Cdd:PRK00133 340 ARTYLDHLDPDYLRYYLAAKLPETIdDLDFNwedfQQRVNSelVGKVVNFASRTAGF----INKRFdgKLPD-------A 408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 602 LADQWILTRLNETISTVTELSEKYEFGEVGRALY------NFIWDEFCDWyiEMSKipmngEDESQKQTTRSVLSYVLDK 675
Cdd:PRK00133 409 LADPELLEEFEAAAEKIAEAYEAREFRKALREIMaladfaNKYVDDNEPW--KLAK-----QDGERLQAVCSVGLNLFRA 481
|
330 340
....*....|....*....|
gi 394254284 676 IMKMLHPFMPFVTETIWQSL 695
Cdd:PRK00133 482 LAIYLKPVLPELAERAEAFL 501
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
587-695 |
7.06e-13 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 65.69 E-value: 7.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 587 EDFKVEDIDLsGNLSLADQWILTRLNETISTVTELSEKYEFGEVG-RALYNFiwDEFCDWYIEMSKIPMNgedesqkqtt 665
Cdd:cd07959 21 EELIETEGEL-EELTFIDRWLLSRLNRLIKETTEAYENMQFREALkEGLYEL--QNDLDWYRERGGAGMN---------- 87
|
90 100 110
....*....|....*....|....*....|
gi 394254284 666 RSVLSYVLDKIMKMLHPFMPFVTETIWQSL 695
Cdd:cd07959 88 KDLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
389-741 |
3.49e-10 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 63.58 E-value: 3.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 389 NTFNRWMEE-IRDWTISRQLW-WGhqIPAwyhkdtgevfvgeeaPEDienwiqDEDVLDTWFSSALWPFSTLGwPDTNAD 466
Cdd:PLN02224 255 NEVQSWIKSgLRDFSISRALVdWG--IPV---------------PDD------DKQTIYVWFDALLGYISALT-EDNKQQ 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 467 DFKRY----YPTNALVTGYDIIFF----WVARMIFQGLEFTDRrpfndVLLHGLVrAEDGRKMSKSLGNGVDPMDVIDEY 538
Cdd:PLN02224 311 NLETAvsfgWPASLHLIGKDILRFhavyWPAMLMSAGLELPKM-----VFGHGFL-TKDGMKMGKSLGNTLEPFELVQKF 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 539 GADSLRYFLATGSSPGHDLRYSTEKVESVWN--FINKIWNAARFSL----MNIGEDFKVEDIDLSGNLSLADQwiLTRLN 612
Cdd:PLN02224 385 GPDAVRYFFLREVEFGNDGDYSEDRFIKIVNahLANTIGNLLNRTLgllkKNCESTLVEDSTVAAEGVPLKDT--VEKLV 462
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 613 ETISTVTE---LSEKYE-FGEVGRALYNFIwDEFCDWYIemskIPMNGEDESQKQTTRSVLSYVLDKIMKMLHPFMPFVT 688
Cdd:PLN02224 463 EKAQTNYEnlsLSSACEaVLEIGNAGNTYM-DQRAPWFL----FKQGGVSAEEAAKDLVIILEVMRVIAVALSPIAPCLS 537
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 394254284 689 ETIWQSLPHHGETIVKASWPTVDQALIfnESKQTMEQLVEIIksvrqSRVEVN 741
Cdd:PLN02224 538 LRIYSQLGYSEDQFNSITWSDTKWGGL--KGGQVMEQASPVF-----ARIELN 583
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
201-325 |
1.40e-08 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 55.25 E-value: 1.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 201 FKYPYADGNGYIEIATTRPETMLGDTAIVVNPN--------------------------DERYKDVIGKT-------VIL 247
Cdd:pfam13603 12 ITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEhplveklaeknpevaafieeckntseIERTSETKEKEgvftglyAIH 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 248 PIVGRELPILADEYVDIEFGSGA-MKVtPAHDPNDFEIGQRHQLENIIV----------------MDEYGKM-NekADKY 309
Cdd:pfam13603 92 PITGEKIPIWIANFVLMEYGTGAvMAV-PAHDQRDFEFAKKYNLPIKPViqpedgdldldimteaYTEEGILvN--SGEF 168
|
170
....*....|....*.
gi 394254284 310 KGMDRFDCRNQLVKDL 325
Cdd:pfam13603 169 DGLDSEEAKEAIIKKL 184
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
517-579 |
5.93e-07 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 52.80 E-value: 5.93e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 394254284 517 DGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATG--SSPghdLRYSTEKVESVWNFINKIWNAAR 579
Cdd:COG0215 262 NGEKMSKSLGNFFTVRDLLKKYDPEVLRFFLLSAhyRSP---LDFSEEALEEAEKALERLYNALR 323
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
560-695 |
8.03e-07 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 48.76 E-value: 8.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 560 STEKVESVWNFINKIWnaaRFSLMNIGEDfkvEDIDLSGNLSLADQWILTRLNETISTVTELSEKYEFGEVGRALYnfiw 639
Cdd:cd07958 2 SDSGVEGAYRFLNRVW---RLVTELAEAL---AAPAAAAELSEEDKELRRKLHKTIKKVTEDIERLRFNTAIAALM---- 71
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 394254284 640 dEFCDwyiEMSKIPMNGEDEsqkqttRSVLSYVLDKIMKMLHPFMPFVTETIWQSL 695
Cdd:cd07958 72 -ELVN---ALYKYKKKDAQH------AAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
569-695 |
2.24e-05 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 44.79 E-value: 2.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 569 NFINKIWN-AARFSlmnigeDFKVEDIDlsgNLSLADQWILTRLNETISTVTELSEKYEFGEVGRALYNFIwdEFCDWYI 647
Cdd:cd07957 11 NLVNRTLNmASKYF------GGVVPEFG---GLTEEDEELLEEAEELLEEVAEAMEELEFRKALEEIMELA--RAANKYI 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 394254284 648 EMSKiPMNGEDESQKQTTRSVLSYVLD---KIMKMLHPFMPFVTETIWQSL 695
Cdd:cd07957 80 DETA-PWKLAKEEDPERLATVLYVLLEllrILAILLSPFMPETAEKILDQL 129
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|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
502-551 |
3.15e-05 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 46.03 E-value: 3.15e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 394254284 502 RPFNDVLLH-GLVRAeDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGS 551
Cdd:cd00672 156 KPFARYWLHtGHLTI-DGEKMSKSLGNFITVRDALKKYDPEVLRLALLSSH 205
|
|
| argS |
PRK01611 |
arginyl-tRNA synthetase; Reviewed |
488-549 |
2.13e-03 |
|
arginyl-tRNA synthetase; Reviewed
Pssm-ID: 234964 [Multi-domain] Cd Length: 507 Bit Score: 41.68 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 394254284 488 VARMiFQGLEFTDRRPFN-DVLLH---GLVRAEDGRKMSKSLGNGVDPMDVIDE-----------------YGADSLRYF 546
Cdd:PRK01611 287 FKRL-KAALKALGYDPDAlEVLLHqmvGLVRGGEGVKMSTRAGNVVTLDDLLDEavgrarelieekeiaeaVGIDAVRYF 365
|
...
gi 394254284 547 LAT 549
Cdd:PRK01611 366 DLS 368
|
|
| ArgS |
COG0018 |
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA ... |
506-547 |
2.15e-03 |
|
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439789 [Multi-domain] Cd Length: 574 Bit Score: 41.67 E-value: 2.15e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 394254284 506 DVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEY-----------------------GADSLRYFL 547
Cdd:COG0018 365 EHLLFGMVNLRDGEKMSTRAGTVVTLDDLLDEAverareiieekseeekeeiaeqvGIDAVRYFD 429
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
517-567 |
3.88e-03 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 40.43 E-value: 3.88e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 394254284 517 DGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSpGHDLRYSTEKVESV 567
Cdd:pfam01406 250 DGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLSVHY-RSPLDFSEELLEQA 299
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