|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
62-439 |
7.18e-68 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 220.50 E-value: 7.18e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 62 AWTVVFGAACGLVVSFGWINCIGVFQEYYETHQlkEYSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFH 141
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEF--GESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 142 VFGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTWFFRRRALALGITASGSSLGGVIFPIMVERLIPQVGFGW 221
Cdd:cd17352 79 ALGLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 222 TMRICAFLILGLMVVANLTIVsripprptpvrpkdfvvpFKEVSFSLLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQ 301
Cdd:cd17352 159 ALLILGGLCLNLCVCGLLLRL------------------LKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 302 KYLVSILNAASTFGRTIPPFYADR--VGRFTVFLSMSLLCALITLCLWLPGSgEAATIVFAVLYGFGSGAVASILPACIA 379
Cdd:cd17352 221 AFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATT-YVGLIVFSVLFGFCSGSYSSLTPVILA 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 378732173 380 HISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRG-YRSMQGFSGGMLAAGFGVYLVL 439
Cdd:cd17352 300 DLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGdYDAAFYFCGACLLLSGVLLFLL 360
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
60-442 |
3.36e-30 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 120.76 E-value: 3.36e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 60 AKAWTVVFGAACGLVVSFGWINCIGVFQEYYEthQLKEYSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTF 139
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLA--EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 140 FHVFGLMMASISTTYYQFLLSqGVCSALGASMIFYPSMSAVVTWFF-RRRALALGITASGSSLGGVIFPIMVERLIPQVG 218
Cdd:COG2223 79 LLGIGLLLLALAVSYWLLLLL-GLLLGIGGGGSFAVGIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 219 FGWTMRICAFLILGLMVVANLTI--VSRIPPRPTPVRPKDFVVPFKEVSFSLLALGSFLTFlGLFLPFTFIIVT--ARAR 294
Cdd:COG2223 158 WRNAFLILGILLLVVAVLAWLFLrdPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTF-GSFIGFSSWLPPylVDQF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 295 HVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLSMSLLCALITLCLWLPGSGEAATIVFAVLYGFGSGAVASIL 374
Cdd:COG2223 237 GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAV 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 378732173 375 PACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRG-YRSMQGFSGGMLAAGFGVYLVLWLR 442
Cdd:COG2223 317 FALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRR 385
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
49-437 |
2.14e-29 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 119.46 E-value: 2.14e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 49 PMDPSQF--PDGGAkAWTVVFGAACGLVVSFGWINCIGVFqeYYETHQLKEYSSQEVAWIPSLEAFMMFVGGLWVGRIYD 126
Cdd:TIGR00892 3 PALPPEGppPDGGW-GWVVLGATFVSIGFSYAFPKAVTVF--FKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 127 NYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTWFFRRRALALGITASGSSLGGVIF 206
Cdd:TIGR00892 80 RFGCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 207 PIMVERLIPQvgFGWTmriCAFLILG---LMVVANLTIVSRIPPRPTPVRPKDFVVP----------------------- 260
Cdd:TIGR00892 160 APLNQYLFES--FGWR---GSFLILGgllLHCCVCGALMRPVGPSQRVSKSKSKEGLppdgstkklskkstaekinrfld 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 261 ---FKEVSFSLLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADR---VGRFTVFLS 334
Cdd:TIGR00892 235 fslFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLkwiRPHVQYLFS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 335 MSLLCALITLCLWLPGSGEAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLIT 414
Cdd:TIGR00892 315 FALLFNGLTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVD 394
|
410 420
....*....|....*....|....
gi 378732173 415 NRG-YRSMQGFSGGMLAAGfGVYL 437
Cdd:TIGR00892 395 ATKnYKYIFYASGSIVVSA-GLFL 417
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
62-441 |
4.21e-28 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 114.68 E-value: 4.21e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 62 AWTVVFGAACGLVVSFGWINCIGVFQEYYethqlkeysSQEVAW----IPSLEAFMMFVGGL---WVGRIYDNYGPRSLL 134
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPI---------IAEFGWsravISLAFTVGLLAFGLaqpFVGRLLDRFGPRRVM 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 135 LTGTFFHVFGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTWFF-RRRALALGITASGSSLGGVIFPIMVERL 213
Cdd:cd17355 72 LLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFeRRRGLALGILTAGGGLGSLVFLPLGAAL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 214 IPQVGFGWTMRICAFLILGLMVVANLTIVSRIPPRPTPVRPKDFVVP--------FKEVSFSLLALGSFLTFLGLFLPFT 285
Cdd:cd17355 152 IEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASpgstlkeaLRSASFWLLALAFFLCGFAVVGLIV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 286 FIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLSMSLLCALITLCLWLPGSGEAATIVFAVLYGF 365
Cdd:cd17355 232 HLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGL 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 378732173 366 GSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLIT-NRGYRSMqgFSGGMLAAGFGVYLVLWL 441
Cdd:cd17355 312 GWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDrTGSYTAA--WALAVALGLIAALLVLPI 386
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
63-439 |
1.77e-26 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 110.17 E-value: 1.77e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 63 WTVVFGAACGLVVSFGWINCIGVFqeYYETHQLKEYSSQEVAWIPSL----EAFMMFVGGLWVGRiydnYGPRSLLLTGT 138
Cdd:cd17423 2 WVVVLAAFLQNALVFGVLRSFGVF--FVEFVEYFEESAQRVSWITSIglavQQLASPVGSALSTR----YGARPVVMLGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 139 FFHVFGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTWFFRRRALALGITASGSSLGGVIFPIMVERLIPQVG 218
Cdd:cd17423 76 LLSSLGFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 219 FGWTMRICAFLILGLMVVANLTivsrippRPtPVRPKDFVVPFKEVS----FSLLALGSFLTF--------LGLFLPFTF 286
Cdd:cd17423 156 WRGALLLLSALSLHLVPCGALL-------RP-LALPGDPPAPPRSLSaafgLSLLTHRAFLRYalattlinTGYFIPYVH 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 287 IIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYAD-RVGRFTVFLsmSLLCALITLCLWLPGSGEAAT--IVFAVLY 363
Cdd:cd17423 228 LVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADlGPLRLLHLL--VLWTALTGLSLLLLPLAKVYGslLALAVAY 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 378732173 364 GFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRG-YRSMQGFSGGMLAAGFGVYLVL 439
Cdd:cd17423 306 GFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGdYTASFLVAGSFLLLGSLILLTL 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
59-443 |
3.69e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 106.11 E-value: 3.69e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 59 GAKAWTVVFGAACGLVVSFGWINCIGVFQEYYETHQlkEYSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGT 138
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADL--GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 139 FFHVFGLMMASISTTYYQFLLSQgVCSALGASMIFYPSMSAVVTWFF-RRRALALGITASGSSLGGVIFPIMVERLIPQV 217
Cdd:COG2271 83 LLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 218 GFGWTMRICAFLILGLMVVAnltivsripprptpvrpkdfvvpfkevsFSLLALGSFLTFLGLFLPFTFIIV-TARARHV 296
Cdd:COG2271 162 GWRAAFLILGLPGLLLALLR----------------------------FWLLALAYFLVYFALYGFLTWLPTyLVEVRGL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 297 SPHLQKYLVSILNAASTFGRTIPPFYADRVGR-FTVFLSMSLLCALITLCLWLPGSGEAATIVFAVLYGFGSGAVASILP 375
Cdd:COG2271 214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 378732173 376 ACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYRSMQGFSGGMLAAGFGVYLVLWLRL 443
Cdd:COG2271 294 ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
61-433 |
3.99e-24 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 103.46 E-value: 3.99e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 61 KAWTVVFGAACgLVVSFGWINCIGVFQEYyethqLKEY---SSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTG 137
Cdd:cd17353 1 RRWLVLLGAVL-MHLILGYQYAWSVFNPP-----LSSAlgwSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 138 TFFHVFGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTWFFRRRALALGITASGSSLGGVIFPIMVERLIPQV 217
Cdd:cd17353 75 GILFGLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 218 GFGWTMRICAFLILGLMVVANLTIvsRIPPRPTPVRPKDFVVPFKEVSFSLLALGSFL---TFLGLFLPFTF-----IIV 289
Cdd:cd17353 155 GVPTTFLILGIIFLIIIVIGAFLI--RDPPKGWVPPGVDPLANNAENSPRDYTPREMLrtpTFWLLWLMFFLnatagLML 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 290 TARA-------RHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLSMSLLCALITLCLWLPGSGEAATIVFAVL 362
Cdd:cd17353 233 IGQAkpigqefAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVAL 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 378732173 363 YGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYRSMQGFSGGMLAAGF 433
Cdd:cd17353 313 IGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVAL 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
99-401 |
1.22e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 101.20 E-value: 1.22e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 99 SSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQgVCSALGASMIFYPSMS 178
Cdd:COG2814 43 SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAAR-FLQGLGAGALFPAALA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 179 AVVTWF-FRRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWtmricAFLILGLMVVANLTIVSRIPPRPTPVRPKDF 257
Cdd:COG2814 122 LIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW-----VFLVNAVLALLALLLLLRLLPESRPAARARL 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 258 VVPFKEV----SFSLLALGSFLTFLGLFLPFTFIIVTARAR-HVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVF 332
Cdd:COG2814 197 RGSLRELlrrpRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL 276
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 378732173 333 LSMSLLCALITLCLWLPGSGeAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIA 401
Cdd:COG2814 277 LIGLLLLALGLLLLALAGSL-WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
63-439 |
1.80e-22 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 98.35 E-value: 1.80e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 63 WTVVFGAACGLVVSFGWINCIGVFqeYYETHQLKEYSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHV 142
Cdd:cd17427 2 WAVVFGAFISIGFSYAFPKAITVF--FKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 143 FGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTWFFRRRALALGITASGSslggvifPIMVERLIPQ-----V 217
Cdd:cd17427 80 LGMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGS-------PVFLSTLAPLnqflfN 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 218 GFGWTmriCAFLILGLMVVANLTIVSRIpprpTPVRPKdfvvpFKEVSFSLLALGSFLTFLGLFLPFTFIIVTARARHVS 297
Cdd:cd17427 153 QFGWR---GSFLILGGLLLNCCVAGSLM----RPLGPL-----FKHRGFLIYLSGNVIMFLGFFAPIVFLAPYAKHMGID 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 298 PHLQKYLVSILNAASTFGRTIPPFYADRV---GRFTVFLSMSLLCALITLCLWLPGSGEAATIVFAVLYGFGSGAVASIL 374
Cdd:cd17427 221 EYSAAFLLSILAFVDMFARPSMGLVANSKwirPRIQYFFSFAVMYNGVCHLLCPLAEDYTGLVIYAVFFGFAFGMVSSVL 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 378732173 375 PACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYRSMQGFSGGMLAAGFGVYLVL 439
Cdd:cd17427 301 FETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWLFI 365
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
63-412 |
2.89e-22 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 98.03 E-value: 2.89e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 63 WTVVFGAACGLVVSFGWINCIGVFqeYYETHQLKEYSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHV 142
Cdd:cd17426 2 WAVVLGAFISIGFSYAFPKSITVF--FKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 143 FGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTWFFRRRALALGITASGSslggvifPIMVERLIP--QVGFG 220
Cdd:cd17426 80 AGLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGS-------PVFLSTLAPlnQWFFD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 221 WTMRICAFLILGLMVVANLTIVSRIpprpTPVRPKDFV--VPFKEVSFSLLALGSFLTFLGLFLPFTFIIVTARARHVSP 298
Cdd:cd17426 153 IFGWRGSFLILGGLLLNCCVAGSLM----RPIGPKPFLdlTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 299 HLQKYLVSILNAASTFGRTIPPFYADRV---GRFTVFLSMSLLCALITLCLWLPGSGEAATIVFAVLYGFGSGAVASILP 375
Cdd:cd17426 229 ESAAFLLSILAFVDMVARPSMGIVANTKwvrPRIQYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLF 308
|
330 340 350
....*....|....*....|....*....|....*..
gi 378732173 376 ACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQL 412
Cdd:cd17426 309 ETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRL 345
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
99-412 |
5.21e-21 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 94.55 E-value: 5.21e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 99 SSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVCSAlGASMIFYPSMS 178
Cdd:COG2807 51 SATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA-GIAVGNVLLPG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 179 AVVTWFFRRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFLILGLMVVANLTIVSRIPPRPTPVRPKDFV 258
Cdd:COG2807 130 LIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLR 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 259 VPFKEVSFSLLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVG--RFTVFLSMS 336
Cdd:COG2807 210 SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGdrRPLLLLLGL 289
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 378732173 337 LLCALITLCLWLPGSgeaATIVFAVLYGFGSGAVASILPACIAHISHI-HQIGVRTGVLFSVVAIAVLIGSPIGGQL 412
Cdd:COG2807 290 LGLAGLLGLLLAPGS---LPWLWAVLLGLGQGGLFPLALTLIGLRARTpAEAAALSGMAQSVGYLLAALGPLLVGAL 363
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
62-413 |
4.34e-20 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 91.33 E-value: 4.34e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 62 AWTVVFGAACGLVVSFGWINCIGVFqeYYETHQLKEYSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFH 141
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVF--FKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 142 VFGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTWFFRRRALALGITASGSslggvifPIMVERLIP-----Q 216
Cdd:cd17430 79 SLGMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGS-------PVFLSALSPlgqilL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 217 VGFGWTmriCAFLILGLMVVANLTIVSRIpprptpvRPKDFVVpFKEVSFSLLALGSFLTFLGLFLPFTFIIVTARARHV 296
Cdd:cd17430 152 EEYGWR---GGFLILGGLLLNCCTCGAVM-------RPLDFSV-FRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGV 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 297 SPHLQKYLVSILNAASTFGRTIPPFYA--DRVGRFTVFL-SMSLLCALITLCLWLPGSGEAATIVFAVLYGFGSGAVASI 373
Cdd:cd17430 221 PDTEAAFLLSILGFIDIFARPACGVVAglKWVRPRVVYLfSFAMLFNGLTDLCSATAADYGGLVVFCVFFGISYGMVGAL 300
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 378732173 374 LPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLI 413
Cdd:cd17430 301 QFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLV 340
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
99-406 |
5.23e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 90.94 E-value: 5.23e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 99 SSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSqGVCSALGASMIFYPSMS 178
Cdd:pfam07690 30 SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVL-RVLQGLGAGALFPAALA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 179 AVVTWF-FRRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFLILGLMVVANLTIVSRIPPRPTPVRPKDF 257
Cdd:pfam07690 109 LIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 258 VVPFKEVSFS-----LLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVF 332
Cdd:pfam07690 189 SLIVAWKALLrdpvlWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL 268
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 378732173 333 LSMSLLCALITLCLWLPGSGE--AATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGS 406
Cdd:pfam07690 269 LLALLLLILAALGLLLLSLTLssLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
103-433 |
3.59e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 88.76 E-value: 3.59e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 103 VAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQgVCSALGASMIFYPSMSAVVT 182
Cdd:cd17324 36 AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLAR-ALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 183 WF-FRRRALALGITASGSSLGGViFPIMVERLIPQVgFGWtmRICAFLILGLMVVANLTIVSRIPPRPTPVRPKDFVVP- 260
Cdd:cd17324 115 LVpPEKRGRAIGLVFSGLTLGLV-LGRPLGGLLGQL-LGW--RAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSs 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 261 ----FKEVSFSLLALGSFLTFLGLFLPFTFIIVTARAR-HVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLsM 335
Cdd:cd17324 191 llllLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI-A 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 336 SLLCALITLCLWLPGSGEAATIVFAVLYGFGSGAVASILPACIAHISHIHQiGVRTGVLFSVVAIAVLIGSPIGGQLITN 415
Cdd:cd17324 270 LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDH 348
|
330
....*....|....*...
gi 378732173 416 RGYRSMQGFSGGMLAAGF 433
Cdd:cd17324 349 GGWAGVGWVGAALLLLAL 366
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
62-413 |
3.85e-19 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 88.68 E-value: 3.85e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 62 AWTVVFGAACGLVVSFGWINCIGVFqeYYETHQLKEYSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFH 141
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIF--FTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 142 VFGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTWFFRRRALALGITASGSSLGGVIFPIMVERLIPQVGFGW 221
Cdd:cd17425 79 GVGMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 222 TmricaFLILGlMVVANLTIVSRIpprptpVRPKdfvvpFKEVSFSLLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQ 301
Cdd:cd17425 159 S-----FLVFG-GVLLNCCVCGAV------MRPF-----CSNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDESKA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 302 KYLVSILNAASTFGRTIPPFYADR---VGRFTVFLSMSLLCALITLCLWLPGSGEAATIVFAVLYGFGSGAVASILPACI 378
Cdd:cd17425 222 ALLLSILGFINIFMRPLAGLLSGLpvfKGRRIYLFSLALLLNGLSNLICAISASFPVLLVYCLLYSISMSGIGSLIFQVL 301
|
330 340 350
....*....|....*....|....*....|....*
gi 378732173 379 AHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLI 413
Cdd:cd17425 302 MDTVEMDRFPSALGLFTILESVTILIGPPLAGLLV 336
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
63-439 |
1.62e-18 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 86.73 E-value: 1.62e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 63 WTVVFGAACGLVVSFGWINCIGVF----QEYYEThqlkeySSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGT 138
Cdd:cd17422 2 WAVAVAFFFVEVFTYGVIKSFGVFfndlMSYFNE------TNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 139 FFHVFGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTWFFRRRALALGITASGSSLGGVIFPIMVERLIPQVG 218
Cdd:cd17422 76 LLISLGMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 219 FGWTMRICAFLILGLMVVANLTIVsripprptpvrpkdfvvpFKEVSFSLLALGSFLTFLGLFLPFTFIIVTARARHVSP 298
Cdd:cd17422 156 WRYCLLVVGALQLNIVVCGALLRV------------------LKEPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 299 HLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLSMSLLCALITLCLWLP-GSGEAATIVFAVLYGFGSGAVASILPAC 377
Cdd:cd17422 218 DWAAYMLSAMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPfAYGFWSLLVCSIFYGFMFGTVAGTHIPL 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 378732173 378 IAH--ISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYRSMQGFSGGMLAAGFGVYLVL 439
Cdd:cd17422 298 LAEddVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLAL 361
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
108-439 |
2.11e-18 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 86.49 E-value: 2.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 108 SLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVcsaLGASM-IFYPSMSAVVTWFF- 185
Cdd:cd17489 38 GLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI---HGIGWgAFTTAAATLVADIIp 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 186 -RRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFLILGLMVVANLTIVSRIPPRPTPVRPKDFVVPFKEV 264
Cdd:cd17489 115 pSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEK 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 265 SFSLLALGSFLTFLGLFLPFTFIIVTARARHVSphlQKYLVSILNA-ASTFGRTIPPFYADRVGRFTVFLSMSLLCALIT 343
Cdd:cd17489 195 KVLPPALILFLASIAYGAISTFLPLYAAERGIS---NAGLFFTVYAiALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 344 LCLWLPGSgEAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYRSMQG 423
Cdd:cd17489 272 LLLSFAGS-PWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFL 350
|
330
....*....|....*.
gi 378732173 424 FSGGMLAAGFGVYLVL 439
Cdd:cd17489 351 LAAVVVLLALVLYIFL 366
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
63-438 |
1.36e-17 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 84.00 E-value: 1.36e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 63 WTVVFGAACGLVVSFGWINCIGVFQEYYETHQLkeYSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHV 142
Cdd:cd17314 2 WFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFG--YSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 143 FGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTWFFRRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWT 222
Cdd:cd17314 80 AGYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 223 MricafLILGLMVVANLTIVSRIPPRPTPVRPKDFVVP----------FKEVSFSLLALGSFLTFLGLFLPFTFIIVTAR 292
Cdd:cd17314 160 Y-----TILGILAAIVLSVVSLLGFKEPPDNQARLHVQkkktqtmgeiFRDKVFWILFIAIFLVLIGGFLFIANMASLVR 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 293 A-RHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLSMSLLCALITLC--LWLPGSGEAATIVFAVLYGFGSGA 369
Cdd:cd17314 235 SlQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTILGLGLCafLFLLKMTPVGLVLTGSLLGFSYGG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 370 VASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLI-TNRGYRSMQGFSGGMLAAGFGVYLV 438
Cdd:cd17314 315 LFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYdRTPSYISAVYIYAVIVFLASAILLA 384
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
99-439 |
1.92e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.39 E-value: 1.92e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 99 SSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQgVCSALGASMIFyPSMS 178
Cdd:cd17325 29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVW-PAAM 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 179 AVVTWFF--RRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWtmricAFLILGLMVVANLTIVSRIPPRPTPVRPKD 256
Cdd:cd17325 107 ALIADIAppEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRA-----PFLVCAALALLALVLALLLLPEPRPPPNKR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 257 FVVPFKEVS----------FSLLALGSFLTFLGLFLPFTFIIVTARAR-HVSPHLQKYLVSILNAASTFGRTIPPFYADR 325
Cdd:cd17325 182 AVSAARLRSglrlllrdrrLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 326 VGRFTVFLSMSLLCALITLCLWLPGSGeAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIG 405
Cdd:cd17325 262 IGRKPLILIGLLLSAVALLLLPLATSF-WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
|
330 340 350
....*....|....*....|....*....|....
gi 378732173 406 SPIGGQLITNRGYRSMQGFSGGMLAAGFGVYLVL 439
Cdd:cd17325 341 PLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
63-417 |
2.92e-17 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 82.94 E-value: 2.92e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 63 WTVVFGAACGLVVSFGWINCIGVFQEYYETHQLKEYSsqEVAWIPSLE--AFMMF--VGGLwvgrIYDNYGPRSLLLTGT 138
Cdd:cd17424 2 WMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYA--RTAWIHSIVdcTTMLCapLGSL----ISNHLSCQVGIILGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 139 FFHVFGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTWFFRRRALALGITASGSSLGGVIFPIMVERLIPQVG 218
Cdd:cd17424 76 LLASTGLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 219 FGWTMRICAFLILGLMVVANLTIVSRIPprptpvrpkDFVVpfKEVSFSLLALGSfltflglFLPFTFIIVTARARHVSP 298
Cdd:cd17424 156 WRGALLILGGFVLNLCVCGALMRFLLMP---------DFLV--LAVSVLFLAYGC-------SPPFVYLVPYALSVGVSH 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 299 HLQKYLVSILNAASTFGRTIPPFYADR-----VGRFTVFLSMSL--LCalitlCLWLPGSGEAATIV-FAVLYGFGSGAV 370
Cdd:cd17424 218 QQAAFLMSILGVIDIIGNITFGWLTDRrclkkYRYFCYLFAVGMdgLC-----CLFLPILKTFPLLVpFSFTFGYFDGAY 292
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 378732173 371 ASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRG 417
Cdd:cd17424 293 VALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTG 339
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
99-437 |
1.33e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 80.93 E-value: 1.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 99 SSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVCsALGASMIFYPSMS 178
Cdd:cd06174 29 SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLL-GLGSGLIDPAVLA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 179 AVVTWF-FRRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFLILGLMVVANLTIVSRIPPRPTPVRPK-- 255
Cdd:cd06174 108 LIADLFpERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEea 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 256 -------DFVVPFKEVSFSLLALGSFLTFLGLFLPFTFIIV-TARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVG 327
Cdd:cd06174 188 ssksvlkLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLfLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 328 RFTVFLSMSLLCALITLCLWLPGSGEAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSP 407
Cdd:cd06174 268 GRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPL 347
|
330 340 350
....*....|....*....|....*....|.
gi 378732173 408 IGGQLI-TNRGYRSMQGFSGGMLAAGFGVYL 437
Cdd:cd06174 348 LAGFLLaATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
62-412 |
1.40e-16 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 81.42 E-value: 1.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 62 AWTVVFGAACGLVVSFGWINCIGVFQEYY---ETHQLKEYSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGT 138
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLlerLTKLGDPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 139 FFHVFGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTWFFRRRALALGITASGSSLGGVIFPIMVERLIPQVG 218
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 219 FGWTMRICAFLILGLMVVANLTIVSRIPPRPTPVRP-------KDFVVP--------FKEVSFSLLALGSFLTFLGLFLP 283
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPgrrtlhsRINLFLrkifnveiFKRKRYVIWALGIPLALFGYFVP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 284 FTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVG-------RFTVFLSMSLLCALITLClwlpgSGEAAT 356
Cdd:cd17420 241 YVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPgvkkmylQVLSFVSIGLMSMMIPLC-----NSFGIL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 378732173 357 IVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQL 412
Cdd:cd17420 316 ISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLL 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
166-439 |
6.15e-15 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 76.48 E-value: 6.15e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 166 ALGASMIFYPSMSAVVTWFFRRRALALGITASGSSLGGVIFPIMVERLI------PQVGFGWTMRICAFLILGLMVVANL 239
Cdd:COG2211 123 AYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVaafggdAALGYRLTALIFAVLGLLAFLLTFF 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 240 TIVSRIPPRPTPVRPK-DFVVPFKEVSFSLLALGSFLTFLGLFLPFTFIIVTARAR-HVSPHLQKYLVSILNAASTFGRT 317
Cdd:COG2211 203 GTKERPVPEEEKVSLKeSLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAP 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 318 IPPFYADRVGRFTVFLSMSLLCALITLCLWLPGSGE-AATIVFAVLYGFGSGAVASILPACIAHISHIHQI---GVRTGV 393
Cdd:COG2211 283 LWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNlWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgRRREGL 362
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 378732173 394 LFSV----VAIAVLIGSPIGGQLITNRGYRSMQGFSGGMLAAGFGVYLVL 439
Cdd:COG2211 363 YFGIftfaIKLGQALAGALAGLLLALFGYVAGAAQSPSALTGIRLLFFLL 412
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
188-437 |
8.41e-14 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 72.58 E-value: 8.41e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 188 RALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFLILGLMVVANLTIVSRIPPRPTPVRPKDFVVPFKEVSFS 267
Cdd:cd17370 122 RGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKA 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 268 LLALGSFLTFLGL-FLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLsMSLLCALITLCL 346
Cdd:cd17370 202 FWLYLLAVALFALgNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLI-LGYLSLALAYLG 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 347 WLPGSGEAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYRSMQGFSG 426
Cdd:cd17370 281 FALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSA 360
|
250
....*....|.
gi 378732173 427 GMLAAGFGVYL 437
Cdd:cd17370 361 VLALIALLLLL 371
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
63-412 |
1.02e-12 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 69.06 E-value: 1.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 63 WTVVFGAACGLVVSFGWINCIGVFQEYYETHQLKEYSSQ---EVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTF 139
Cdd:cd17465 2 WVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDQAvqfKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 140 FHVFGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTWFFRRRALALGITASGSSLGGVIFPIMVERLIPQVGF 219
Cdd:cd17465 82 VAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 220 GWTMRICAFLILGLMVvanLTIVSRIpprptpvrpkdfvvpFKEVSFSLLALGSFLTFLGLFLPFTFIIVTARARHVSPH 299
Cdd:cd17465 162 AHTFQVLSLFMFIQIF---LSLTYKV---------------FRRKTYRIWAFGIATAVLGYFVPYVHLMKYVEEEFKENK 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 300 LQKYLVSILNAASTFGRTIPPFYADRV-GRFTVFLSMSLLCALITLCLWLP-GSGEAATIVFAVLYGFGSGAVASILPAC 377
Cdd:cd17465 224 REWVLLVCIGASSGIGRLMSGKIGDLIpGLKKIYLQVASFLLLGIMSMMIPlCQVFEGVIVVCLFLGLCDGCFITIMAPI 303
|
330 340 350
....*....|....*....|....*....|....*
gi 378732173 378 IAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQL 412
Cdd:cd17465 304 AFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLL 338
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
102-441 |
1.46e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 68.73 E-value: 1.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 102 EVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSqGVCSALGASMIFyPSMSAVV 181
Cdd:COG0738 44 QAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLA-LFLLGLGLGLLD-VAANPYV 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 182 TWFFRR-RALALGITASGSSLGGVIFPIMVERLI-PQVGFGWTM--RICAFLILGLMVVANLTIVSRIPPRP--TPVRPK 255
Cdd:COG0738 122 AALGPEtAASRLNLLHAFFSLGALLGPLLGGLLIlLGLSLSWHLpyLILAVLLLLLALLFLRSKLPEIEEEEeeAAGSAA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 256 DFVVPFKEVSFSLLALGSFLTFLGLFLPFTFIIVTAR-ARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLS 334
Cdd:COG0738 202 SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKdVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRL 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 335 MSLLCALITLCLWLpGSGEAATIVFAVLYGFGsgaVASILPACIAHIshIHQIGVRTGVLFSVVAIAVLIGSPIGGQLIt 414
Cdd:COG0738 282 SALLAAVGLLLALL-APGPWLALIGLALVGLG---LSLMFPTIFSLA--LDGLGKRTAAAVSAVLIMGIVGGAIGPPLI- 354
|
330 340
....*....|....*....|....*..
gi 378732173 415 nrgyrsmqgfsgGMLAAGFGVYLVLWL 441
Cdd:COG0738 355 ------------GFLADAFGLRAAFLV 369
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
99-413 |
3.86e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 67.65 E-value: 3.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 99 SSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFhvFGLMMASIS-TTYYQFLLSQGVCSALGASMIFYPSM 177
Cdd:cd17475 29 SLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLL--MGAAALLMAlVGSYPVLLVLLFLVGAGYGSVQPGGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 178 SAVVTWF-FRRRALALGITASGSSLGG----VIFPIMVERlipqvgFGWTMricAFLILGLMVVANLTIVSRI---PPRP 249
Cdd:cd17475 107 RAIMRWFpPRERGLAMGIRQTGVPLGGalaaALLPPLALH------YGWRA---AFVVAGLVSILAAVLFWLFyrePPAA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 250 TPVRPKDFVV-----------PFKEVSFSLLALG----SFLTFLGLFLpftfiivtARARHVSPHLQKYLVSILNAASTF 314
Cdd:cd17475 178 SAATESASTLlrslkevlrnrDVWLIAIAGALLVapqfALLTFLLLFL--------HDHLGLSVVAAGALLAVAQLGGAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 315 GRTIPPFYADRVG---RFTVFLSMSLLCALITLCLWLPGSGEAATIVFAVLYGFGSGAVA--SILPACIAHISHIHQIGV 389
Cdd:cd17475 250 GRIGLGRVSDRVFggrRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGwnGLYLTLVAESAGPEQAGT 329
|
330 340
....*....|....*....|....
gi 378732173 390 RTGVLFSVVAIAVLIGSPIGGQLI 413
Cdd:cd17475 330 ALGLANTINFIGIAIGPPLFGLLV 353
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
104-410 |
7.27e-12 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 66.39 E-value: 7.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 104 AWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTW 183
Cdd:cd17429 41 AWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSLGWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 184 FFRRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFLILGLMVVANLTIVsripprptpvrpkdfvvpFKE 263
Cdd:cd17429 121 FQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAMFIQGAVSLNLCVCGALMRL------------------FTN 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 264 VSFSLLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKY-LVSILNAASTFGRTIPPFYADR--VGRFTVFLSMSLLCA 340
Cdd:cd17429 183 KVFVAFIFWALFAYCSFVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLpcISVWNVFILANFTLG 262
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 341 LITLCLWLPGSGEAATIVFAVLyGFGSGAVaSILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGG 410
Cdd:cd17429 263 VCILILPLMHTYTGLAIVCALI-GFSSGYF-SLMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAG 330
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
104-412 |
7.42e-12 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 66.74 E-value: 7.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 104 AWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTW 183
Cdd:cd17464 46 AWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGAAVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHY 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 184 FFRRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFLILGLMvVANLTIVSRIPPR------------PTP 251
Cdd:cd17464 126 FKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVGLFNTLRVLCIFMFVLF-LAGFTYKPLVPMKkdkegkkrkfkcPPL 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 252 VRPKDFVVpFKEVSFSLLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRV-GRFT 330
Cdd:cd17464 205 KKIFNFNI-WKSTGYRIWAFGIPAALFGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYIpGVKK 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 331 VFLSMS------LLCALITLClwlpgSGEAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLI 404
Cdd:cd17464 284 VYLQVSsfffigLMSMMIPLC-----HVFGGLIAVCLFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTV 358
|
....*...
gi 378732173 405 GSPIGGQL 412
Cdd:cd17464 359 GPPIAGFL 366
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
63-410 |
8.58e-12 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 66.38 E-value: 8.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 63 WTVVFGAACGLVVSFGWINCIGVFqeYYETHQLKEYSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHV 142
Cdd:cd17428 2 WVIVFVSFLAQFLCYGSPLAVGVL--YPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 143 FGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVTWFFRRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWT 222
Cdd:cd17428 80 GGLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGC 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 223 MRICAFLILGLMVVANLTIVsripprptpvrpkdfvvpFKEVSFSLLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQK 302
Cdd:cd17428 160 LLIVGALALNLLACGSLMRL------------------FKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIAL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 303 Y-LVSILNAASTFGRTIPPFYADRVGRFTVFLSMSLLCALITLCLWLPGSGEAATI-VFAVLYGFGSGAvASILPACIAH 380
Cdd:cd17428 222 IpLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLaVLSAILGFLSGN-WSIFPYVTTK 300
|
330 340 350
....*....|....*....|....*....|
gi 378732173 381 ISHIHQIGVRTGVLFSVVAIAVLIGSPIGG 410
Cdd:cd17428 301 TVGIEKLGHAYGILMFFAGLGNSLGPPIVG 330
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
260-443 |
6.50e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 63.45 E-value: 6.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 260 PFKEVSFSLLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLSMSLLC 339
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 340 ALITLCLWLPGSgEAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYR 419
Cdd:COG2814 86 ALGSLLCALAPS-LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180
....*....|....*....|....
gi 378732173 420 SMQGFSGGMLAAGFgvyLVLWLRL 443
Cdd:COG2814 165 WVFLVNAVLALLAL---LLLLRLL 185
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
66-435 |
1.37e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 62.62 E-value: 1.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 66 VFGAACGLVVSFGWINCIGVFQEYYETHQLKEYSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGL 145
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 146 MMASISTTYYQFLLS---QGVcsALGASmifYPSMSAVVT--WFFRRRALALGITASGSSLGGVIFPIMVERLIPQVGFG 220
Cdd:cd17316 81 LLIGLLPTPILLLVLrflQGI--GIGGE---YPGASTYVAefAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 221 WTMRIcAFLILGLMVVANLTIVSRIpprptpvrpkdfvvpfkevsfSLLALGSFLTFLGLFLPFTFII-VTARARHVSPH 299
Cdd:cd17316 156 WGWRI-LFLIGALPALLALLLRRRT---------------------LLLILLWFFISFGYYGLTTFLPtYLQTVLGLSPA 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 300 LQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLSMSLLCALITLCLWLPGSGEAATIVFA-VLYGFGSGAVASILPACI 378
Cdd:cd17316 214 TSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLlFILSFFVGGVWGALYAYL 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 378732173 379 AHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYRSMQGFSGGMLAAGFGV 435
Cdd:cd17316 294 AELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
98-379 |
4.22e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 61.03 E-value: 4.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 98 YSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVcSALGASmIFYPSM 177
Cdd:cd17478 28 LSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL-AGIGSA-AFHPEG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 178 SAVVTWFF-RRRALALGITASGSSLGGVIFPIMVerlIPQVGFGWTMRICAFLILGLMVVANLTIVSRIPPRPTPVRPKD 256
Cdd:cd17478 106 ARLASQAAgGRRGLAMSIFSVGGNLGFALGPLIA---AALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 257 FVV---PFKEVSFSLLALGSFLTFLGLFLP--FTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTV 331
Cdd:cd17478 183 KSSarsTLKGVWRALLLLLIIVFLRSWVLSslTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRV 262
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 378732173 332 FLSmSLLCALITLcLWLPGSGEAATIVFAVLYGFgsgAVASILPACIA 379
Cdd:cd17478 263 IIA-SLLLAAPFL-LLFLLTPGIWSYILLVLAGF---LLFASFPVTVV 305
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
111-437 |
5.05e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 61.05 E-value: 5.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 111 AFMMFVgglwVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVcSALGASMIFYPSMSAVVTWF-FRRRA 189
Cdd:cd17474 48 AVLMPV----AGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRAL-QGIGAAGLGPLALTLIGDLFeGGERA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 190 LALGITASGSSLGGVIFPIMVERLipqVGFGWtmRICAFLILGLMVVANLTIVSRIPPRPTPVRPKDFVVPFKEV----- 264
Cdd:cd17474 123 KAMGLYEAALGLGIAVGPLLGGLL---AAISW--RYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKkalrg 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 265 -SFSLLALGSFLTFLGLFLPFTFI-IVTARARHVSPHLQKYLVSILNAASTFGRTI-PPFYADRVGRFTVFLSMSLLCAL 341
Cdd:cd17474 198 rGLLTFLVSAFLYFFLYFAFLTYLpFLLELLYGISPIIIGLLFAGWSVLLALGSLFvGRLLKKRFGARRILVIGLLLYAL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 342 ItLCLWLPGSGEAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYRSM 421
Cdd:cd17474 278 S-LLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAP 356
|
330
....*....|....*.
gi 378732173 422 QGFSGGMLAAGFGVYL 437
Cdd:cd17474 357 FLVGAAIALAAAVLLA 372
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
103-439 |
3.18e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 58.35 E-value: 3.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 103 VAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLS---QGVCSALgasmiFYPSMSA 179
Cdd:cd17473 37 VPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASralLGIGVAG-----IMTLATA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 180 VVTWFF--RRRALALGITASGSSLGGVIFPIMVERLipqVGFGWTMricAFLILGLMVVANLTIVSRIPPRPTPVRPKDF 257
Cdd:cd17473 112 LIGDYFegEERAKMLGLQSAAMSLGGVVFLLLGGAL---AEIGWRA---PFLVYLLALPVLILVLLFLPEPARKSKSAAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 258 VVPFKEVSFS-----LLALGSFLTFLGLFLPFTFIIVTARARH-VSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTV 331
Cdd:cd17473 186 PGAATAAALPwkrvlPIYFLAFLAMLLFYVIPIQLPFLLQERGgGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 332 FLSMSLLCALITLCLWLPgSGEAATIVFAVLYGFGSGAvasILPACIAHISHIHQIGVRTGVLfSVVAIAVLIG---SPI 408
Cdd:cd17473 266 LAIGFALMALGFLLLALA-SGLWVVLLGAILAGLGFGL---LLPTLNSWAMSLVPPELRGRAM-GIVTSAFFLGqflSPL 340
|
330 340 350
....*....|....*....|....*....|...
gi 378732173 409 GGQLITNR--GYRSMQGFSGGMLAAGFGVYLVL 439
Cdd:cd17473 341 VLGPLVNLtgGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
99-416 |
7.18e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 57.18 E-value: 7.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 99 SSQEVAWIPSleAFMMFVGGLWV--GRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVcSALGASMIFyPS 176
Cdd:cd17321 29 SPSQLQWVVN--AYLLAFAALLLlaGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARAL-QGIGAAAIM-PA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 177 MSAVVTWFFR--RRALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFLILGLMVVAnltivsripprptpvrp 254
Cdd:cd17321 105 SLALIAATFPgeRRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA----------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 255 kdfvVPFKEVSFSLLALGSFLTFLGLFLPFTFIIVtaraRHVSPHLQKYLVSILNAASTFGRTIPPFYADRVG-RFTVFL 333
Cdd:cd17321 168 ----RTFSGAVLAAFLLGAALGGLLFLLPLYLQGV----LGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGpRLVLVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 334 SMSLLCA-LITLCLWLPGSGEAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQL 412
Cdd:cd17321 240 GLLLTAVgLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
....
gi 378732173 413 ITNR 416
Cdd:cd17321 320 LTAG 323
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
93-439 |
7.87e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 57.24 E-value: 7.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 93 HQLKEYSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLS---QGVCSALga 169
Cdd:cd17329 27 HQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIAlvlTGFGGGL-- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 170 smiFYPSMSAVVT--WFFRRRALALGITASGSSLGGVIFPIMVERLIpQVGFGWtmricAFLILGLMVVANLTIVSRIPP 247
Cdd:cd17329 105 ---FEPASEAMIAdvTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRL-----LFLAAAVLFLLAALVLLFLLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 248 RPTPVRPKDFVVPFKEVSFSLLALGSFLTFLGLFLPFTFI---------IVTARARHVSPHLQKYLVSIlNAASTFGRTI 318
Cdd:cd17329 176 ETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIyfqlestlpVYVVEILGLGESLLGLLLAL-NALLIVLLQF 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 319 PpfYADRVGRFTVFLSMSLLCALITL-CLWLPGSGE-AATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFS 396
Cdd:cd17329 255 P--VARLVERFRLRKILMIGILLFAIgFAVLAFANTlAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYAL 332
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 378732173 397 VVAIAVLIGSPIGGQLITNRGYRSMQGFSGGMLAAGFGVYLVL 439
Cdd:cd17329 333 AWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
85-438 |
1.09e-08 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 56.75 E-value: 1.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 85 VFQEYYEThqlkeySSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVC 164
Cdd:cd17421 28 AFQEEFGG------SSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSAGFLISIFATSVPFLYVSMGLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 165 SALGASMIFYPSMSAVVTWFFRRRALALGITASGSSLGGVIFPiMVERLIPQvgFGWTmriCAFLILGLMVVaNLTIVSR 244
Cdd:cd17421 102 VGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFALAP-FTQLLLDE--YDWQ---GALLIFGGIML-NLVASGM 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 245 IpprptpVRPKDFVvPFKEVSFSLLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYAD 324
Cdd:cd17421 175 L------LRPIDFS-LLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIAD 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 325 R--VGRFTVFLSMSLLCALITLCLWLPGSgEAATIVFAVLYG-FGSGAVASILPAcIAHISHIHQIGVRTGVLFSVVAIA 401
Cdd:cd17421 248 QnwIKKYHYHKAYLILCGVTNLLAPLATT-YPLLMTYAVFFAiFCGGYLALLLPV-LVDLVGVTKVNSSLGFSMFFAGIG 325
|
330 340 350
....*....|....*....|....*....|....*..
gi 378732173 402 VLIGSPIGGQLitnrgYRSMQGFSGGMLAAGfGVYLV 438
Cdd:cd17421 326 CLTGPPLAGWL-----YDYTQTYDCSFYLAG-GCYLL 356
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
103-435 |
1.74e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 56.05 E-value: 1.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 103 VAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVCSALGASMIFYPSMSAVVT 182
Cdd:cd17330 36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADIT 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 183 wFFRRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFLilglmVVANLTIVSRIPPRptpvrpkdfvvpfk 262
Cdd:cd17330 116 -DEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAAL-----ALLNLVLVLFFLPP-------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 263 evSFSLLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRT-IPPFYADRVGRFTVFLSmSLLCAL 341
Cdd:cd17330 176 --LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLlLIPRLAKRLGERKLLRL-GLLLAI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 342 ITLCLWLPGSGEAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYRSM 421
Cdd:cd17330 253 IGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVP 332
|
330
....*....|....
gi 378732173 422 QGFSGGMLAAGFGV 435
Cdd:cd17330 333 FLLAAGLLLIALFL 346
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
99-443 |
4.16e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 54.90 E-value: 4.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 99 SSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVCS-ALGASMifyPSM 177
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGlGLGAAM---PNA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 178 SAVVTWFF--RRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFLILGLMVVANLTIvsripprptpvrpk 255
Cdd:cd17365 109 ITLVSEYApaRRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTL-------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 256 dfvvpfkevsfsLLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLSM 335
Cdd:cd17365 175 ------------LLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 336 SLLCALITLCLWLPGSGEAATIVFAVLYGFGSGAVASILPACIAhisHIHQIGVR-TGVLFSVVA--IAVLIGSPIGGQL 412
Cdd:cd17365 243 FALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAA---RFYPTEVRaTGVGWALGVgrLGAILGPLLGGLL 319
|
330 340 350
....*....|....*....|....*....|.
gi 378732173 413 ITnRGYRSMQGFSGGMLAAGFGVYLVLWLRL 443
Cdd:cd17365 320 LA-AGLGPESVFLALAIPAALGALAVLLLRL 349
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
269-439 |
4.97e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 54.73 E-value: 4.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 269 LALGSFLTFLGLFLPFTFIIVT-ARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLsMSLLCALITLCLW 347
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL-IGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 348 LPGSGEAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYRSMQGFSGG 427
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170
....*....|..
gi 378732173 428 MLAAGFGVYLVL 439
Cdd:pfam07690 160 LSLLAAVLLLLP 171
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
269-439 |
6.38e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.50 E-value: 6.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 269 LALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLSMSLLCALITLCLWL 348
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 349 PGSGeAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYRSMQGFSGGM 428
Cdd:cd17325 81 ATSY-WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170
....*....|.
gi 378732173 429 LAAGFGVYLVL 439
Cdd:cd17325 160 ALLALVLALLL 170
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
195-413 |
1.84e-07 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 52.99 E-value: 1.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 195 TASGSSLGGVIFPIMVERL-IPQVGFGWtmRICAFLILGLMVVANLTIVSRIPPRPTPVRPKDFVVPFKEVSFSLLALGS 273
Cdd:cd17332 145 ATIGGLLVTVLPPPLVAYFgGGNASRGY--FLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLKALLKNRP 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 274 FLTFLGLFLpFTFIIVTARA----------RHVSPHLQKYLVSILnAASTFGRTIPPFYADRVGRFTVFLsMSLLCALIT 343
Cdd:cd17332 223 FLILLLAYL-LYFLAFNIVNtvlvyyfkyvLGGRAELVLLLLLIL-SGALLALLPWPPLKKRFGKKKAFF-IGLLLAILG 299
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 378732173 344 LCLW--LPGSGEAATIVFAVLYGFGSGAVASILPACIAHISHIHQI--GVR-TGVLFSVVAIAVLIGSPIGGQLI 413
Cdd:cd17332 300 LLLLffLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGELktGKRrEGIFYSVMTFFRKLGLALAGALV 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
98-439 |
2.82e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.23 E-value: 2.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 98 YSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVCSAL---GASMIFY 174
Cdd:cd06173 31 GSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFllgIASAFFG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 175 PSMSAVVTWFFRRRAL--ALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFLILgLMVVANLTIvsRIPPRPTPV 252
Cdd:cd06173 111 PARQALLPELVPKEQLvrANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFL-LSALLLLFI--RRPPPAAPG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 253 RPKDFVVPFKEVSF----------SLLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFY 322
Cdd:cd06173 188 ESSSLLLRDLREGLrylrrspllrLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 323 ADRVGRFTVFLSMSLLCALITLCLWLPGSGeAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAV 402
Cdd:cd06173 268 SKRRRRGRLLLIGALLLGLALLVLGLSPSL-WLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAM 346
|
330 340 350
....*....|....*....|....*....|....*..
gi 378732173 403 LIGSPIGGQLITNRGYRSMQGFSGGMLAAGFGVYLVL 439
Cdd:cd06173 347 PLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
268-439 |
1.50e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 50.24 E-value: 1.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 268 LLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLSMSLLCALITLCLW 347
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 348 LPGSGeAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYR-SMQGFSG 426
Cdd:cd17324 83 LAPSF-ALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRaAFLAIAV 161
|
170
....*....|...
gi 378732173 427 GMLAAGFGVYLVL 439
Cdd:cd17324 162 LALLAALLLWRLL 174
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
73-416 |
1.62e-06 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 50.32 E-value: 1.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 73 LVVSFGWINCIGVFQeyYETHQLKEY-----SSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMM 147
Cdd:cd06179 1 AALCLAYFAQLFGVT--LPAAVLPFIvadlgPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 148 ASISTTYYQFLLSQGVCS-ALGASMIFYPSMSAVVTwfFRRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRIC 226
Cdd:cd06179 79 AGTAKSVNMLIGGQALIGiGAGTQGLGAAVASELVP--NKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAGWRWIFY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 227 AFLILGLMVVANLTIVSRIPPRPTPVRP--------KDFV---------VPF---------------KEVSfSLLALGSF 274
Cdd:cd06179 157 INAIFNALALILLFFFYHPPPRPQLHGSstrqklkrLDWVglflliaglVLFllglswggnpypwssAHVI-APLVIGGV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 275 LTFL-----------GLFLPFTFI---------------------------IVTARARHVSPHLQKYLVSILNAASTFGR 316
Cdd:cd06179 236 LLIAfglyewkgtkdGLLPPRLLFrgrnfalilivafvegmifyslnifwpQQISLLFTTDPLKAGLYQLPFGLGTLFGA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 317 TIPPFYADRVGR-----FTVFLSMSLLCALITLClwlPGSGEAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRT 391
Cdd:cd06179 316 ILAGLLLTKIKHikwqlVAGFVLFTAFLALLALI---TPDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTAS 392
|
410 420
....*....|....*....|....*
gi 378732173 392 GVLFSVVAIAVLIGSPIGGQLITNR 416
Cdd:cd06179 393 GLLGSARALGGAVGTAIFTSILSNR 417
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
269-441 |
1.68e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 50.12 E-value: 1.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 269 LALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLSMSLLCALITLCLWL 348
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 349 PGSGEAAtIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYRSMQGFSGGM 428
Cdd:cd06174 81 APSFWLL-LLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159
|
170
....*....|...
gi 378732173 429 LAAGFGVYLVLWL 441
Cdd:cd06174 160 ALALLAAILLLLV 172
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
111-439 |
1.87e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 49.88 E-value: 1.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 111 AFMMFVGGLWVgriyDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVCSALGASmiFYPSMSAVVTWFF--RRR 188
Cdd:cd17319 52 ALFQVPGGWLL----DRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAG--FFPGAIKALAEWFpaRER 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 189 ALALGITASGSSLGGVIFPIMVERLIpqVGFGWTMricAFLILGLMVVANLTIVSRIPPRptpvrpkdfvvpFKEVSFSL 268
Cdd:cd17319 126 GRATGLFNSGAPLGAAIGPPLSGWLL--LLFGWRW---AFIIEGLLGLLLAVLWWFYLRQ------------VWGLALGY 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 269 LALGSFLTFLGLFLPfTFIIvtaRARHVSPHLQKYLVSILNAASTFGRTIPPFYADRV--GRFTVFLSMSLLCALITLCL 346
Cdd:cd17319 189 FGINYALYGLLTWLP-TYLK---QARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 347 WLPGSGEAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRG-YRSMQGFS 425
Cdd:cd17319 265 AYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFL 344
|
330
....*....|....
gi 378732173 426 GGMLAAGFGVYLVL 439
Cdd:cd17319 345 AAVALLAALLVLLL 358
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
92-428 |
2.68e-06 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 49.17 E-value: 2.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 92 THQLKE--YSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTT-------YYQFllsqG 162
Cdd:cd17354 26 SPPLKStlGYSQQQNNLLSVAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPGYGVLWLVVTglisdlsFWLM----C 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 163 VCSALGASMIFYPSMSAVVTW---FFRRRALALGITASGSSLGGVIFPIMVERLipqvgFGWT-MRICAFLILGLMVVAN 238
Cdd:cd17354 102 LCFFLIGNSTSSLYTAALVTCaknFPESRGLAIGIPKGCYGLSGAIGSQLYKAL-----FFHDsARVFLFLAVLPAVVGL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 239 L-TIVSRIpprptpVRPKDFVVpFKEVSFSLLALGSFLTfLGLFLpfTFI-----IVTARarhVSPHLQKYLVSILNAAS 312
Cdd:cd17354 177 LaWFSVRI------VSIEEGEF-LKDIDFWLLFISLFLG-VGPGE--MFInnlgqIGQSL---TGPSNTSTLVSLFSIFS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 313 TFGRTIPPFYAD---------RVGRFTVFLSMSLLCALITLCLWLPGSGEAATIVFavlyGFGSGAVASILPACIAHIsh 383
Cdd:cd17354 244 FLGRLLSGLLSDlfvrkfrlpRPSRMVLLLLILSLGHLLQAFGLPSGALYVASALI----GFGYGGLFSIAPTIVSEL-- 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 378732173 384 ihqIGVRT-GVLFSVVAIAVLIGSPIGGQLITNRGYRSMQGFSGGM 428
Cdd:cd17354 318 ---FGLKNfGTNYGFLMLAPAIGSLIFSVIYAGVYYDNGGEGAGSD 360
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
99-344 |
3.04e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 48.65 E-value: 3.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 99 SSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVCsALGASMIFYPSMS 178
Cdd:COG0477 47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQ-GIGAGGLMPGALA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 179 AVVTWF-FRRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWtmricAFLILGLMVVANLTIVSRIPPRPTPVRPKDF 257
Cdd:COG0477 126 LIAELFpARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW-----IFLINAPLGLLALVLRLRLPESRGLLLALLA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 258 VVPFKEVSFSLLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLSMSL 337
Cdd:COG0477 201 LALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLL 280
|
....*..
gi 378732173 338 LCALITL 344
Cdd:COG0477 281 LLLLLLL 287
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
98-237 |
4.80e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 48.34 E-value: 4.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 98 YSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVCSaLGASMIFyPSM 177
Cdd:cd17325 232 LSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLG-LGLGLVF-PAT 309
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 378732173 178 SAVVTWFFRR--RALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFLILGLMVVA 237
Cdd:cd17325 310 LALLADIVPPegRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLF 371
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
102-438 |
8.01e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 47.70 E-value: 8.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 102 EVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSqGVCSALGASMIFYPSMSAVV 181
Cdd:cd17333 32 DVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVL-MFLAGLGAGILDTGANTFVG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 182 TWFFRRRALALGITASGSSLGGVIFPIMVERLIpQVGFGWT---MRICAFLILGLMVVANLTIVSRIPPRPTPVRPKDFV 258
Cdd:cd17333 111 ALFEESSATRLNVLHGFFGLGALIGPLIATSLL-TSELSWSwayLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 259 VPFKEVSFSL-LALGSFLTFLGLFLPFTFIIVT----ARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGrFTVFL 333
Cdd:cd17333 190 ASASRLLRNPsIILGALALFLYVGAETAFSSWVpsylVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIK-PHTLL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 334 SMSLLCALITLCLWLPGSGEAATIVFAVLYGFGSGAVASILPAcIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLI 413
Cdd:cd17333 269 VLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILS-LGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIA 347
|
330 340
....*....|....*....|....*
gi 378732173 414 TNRGYRSMQGFSGGMLAAGFGVYLV 438
Cdd:cd17333 348 EAVGIQTAMLLITILYAIIFVLALL 372
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
266-441 |
2.57e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.96 E-value: 2.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 266 FSLLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLSMSLLCALITLC 345
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 346 LWLPGSGEAAtIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYRSMqgFS 425
Cdd:COG0477 96 CGLAPSPELL-IAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI--FL 172
|
170
....*....|....*.
gi 378732173 426 GGMLAAGFGVYLVLWL 441
Cdd:COG0477 173 INAPLGLLALVLRLRL 188
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
269-440 |
2.77e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.05 E-value: 2.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 269 LALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGRFTVFLSMSLLCALITLcLWL 348
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL-LYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 349 PGSGEAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYRSMQGFSGGM 428
Cdd:cd17489 80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL 159
|
170
....*....|..
gi 378732173 429 LAAGFGVYLVLW 440
Cdd:cd17489 160 ALLALLLVFLVK 171
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
99-365 |
3.12e-05 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 45.76 E-value: 3.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 99 SSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVCSALGAsMIFYPSMS 178
Cdd:cd06180 32 SYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASA-FVFVFGSN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 179 AVVTWFFR-RRALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFLILGLMVVANLTIVSRIPPRPTPVRPkDF 257
Cdd:cd06180 111 LVLHHATAaGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASA-AE 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 258 VVPFKEVSFSLLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVGR---FTVFLS 334
Cdd:cd06180 190 SAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTrraLAANLL 269
|
250 260 270
....*....|....*....|....*....|.
gi 378732173 335 MSLLCALITLCLwlpgSGEAATIVFAVLYGF 365
Cdd:cd06180 270 VQAVGVLLPLLS----PGPAGLVLSAVLFGG 296
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
98-441 |
4.11e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 45.65 E-value: 4.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 98 YSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFH--VFGLMMASISTTYYQFLLSQGVCSALGASMIfyP 175
Cdd:cd17335 29 LSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAavLFFLSLFFVAQIFWLLLLLVILGAFFSAPVV--P 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 176 SMSAVVTWFFRRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICaFLILGLMVVANLTIVSRIPPRPTPVRP- 254
Cdd:cd17335 107 LVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSSTYKNYTIA-FYVFAVLMLLALLLALKFPFRPKHPEPn 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 255 ---KDFVVPFKEVSFSLLALGSFLTFLGLFLPFTFiivtararhVSPHLQ-----KYLVSILNAASTFGRTIPPFYADR- 325
Cdd:cd17335 186 entGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSF---------LFWHLQdlggsKTLIGLLWTVGVVSEIPFFFFSSRl 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 326 VGRF--TVFLSMSLLCALITLCLWLPGSGEAATIVFAVLYGFgsgAVASILPACIAHISHIHQIGVRTGV--LFSVVAIA 401
Cdd:cd17335 257 IQRFghVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGL---TFALVWAAAVSYASAAAPPGLRATAqgLLQGLYFG 333
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 378732173 402 VL--IGSPIGGQLITNRGYRSMQGFSGGMLAAGFGVYLVLWL 441
Cdd:cd17335 334 LGggLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
186-379 |
9.93e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 44.44 E-value: 9.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 186 RRRALALGITASGSSLG-----GVIFPimVERLIPQVGF-GWTMRIcAFLILGLMVVANLTIVSRIPPRPTPVRPKD--- 256
Cdd:cd17369 137 KRRGFYGSFPQLGAPVGlllatGVFLL--LSALLSDEAFlSWGWRI-PFLLSAVLVAVGLYIRLRLEETPVFRRAKEagq 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 257 -FVVPFKEVSFS-----LLALGSFLTFLGLFLPFTFIIVTARARHVSPHLQKYLVSILNAASTFGRTIPPF--YADRVGR 328
Cdd:cd17369 214 vVRAPLVEVLRRhwralLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFgwLSDRVGR 293
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 378732173 329 FTVFLSMSLLCALITLCLWL---PGSGEAATIVFAVLYGFGSGAVASILPACIA 379
Cdd:cd17369 294 RPVYLAGALLAALFAFPFFWlldTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLA 347
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
98-243 |
1.32e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 98 YSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSqGVCSALGASMIFyPSM 177
Cdd:cd17473 230 GSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLG-AILAGLGFGLLL-PTL 307
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 378732173 178 SAVVTWF--FRRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWTmricAFLILGLMVVAnLTIVS 243
Cdd:cd17473 308 NSWAMSLvpPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSG----AFLILGVLALV-LAIVL 370
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
126-376 |
4.81e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 42.24 E-value: 4.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 126 DNYGPRSLLLTGT-FFHVFGLMMASISTTYYQFLLSQGVCSALGASmiFYPSMSAVVTWFFRRRA-LALGITASGSSLGG 203
Cdd:cd17341 59 DRFGGRRVFIASLlLLLIPLLALALAVSSYWGLLVLGFLLGFAGAN--FASGQPWASFWFPKEKIgGAAGGIAGAGNMGV 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 204 VIF-----PIMVERLIPQVGFGWTMricAFLILGLMVVANLTIVSRIP------PRPTPVRPKDFVVPFKEVSFSLLALG 272
Cdd:cd17341 137 AVSqllapLIAGAIVFDGGFVGWRN---AFFVPGILLAIAAVLVLLFGddlptgKASALEFLKVQLAVLKNYRTWILSLL 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 273 SFLTFlGLFLPFTFIIVT-ARAR-HVSPHLQKYLVSILNAASTFGRTIPPFYADRVG----RFTVFLSMSLLCALITLCL 346
Cdd:cd17341 214 YGVTF-GSFVGFSNVLPTyFKTRfGLPLVTAGILAALFPLAGALARPAGGWLSDRFGgrrrLWWLFIVMTIGAALLSLSL 292
|
250 260 270
....*....|....*....|....*....|....
gi 378732173 347 WLPGSGEAATIVFAVLY----GFGSGAVASILPA 376
Cdd:cd17341 293 PTSGTNLVLFLALFVALglgaGAGNGSVFRMVPF 326
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
93-242 |
6.08e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.79 E-value: 6.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 93 HQLKEYSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGP-RSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVCSALGASM 171
Cdd:cd17319 207 KQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 378732173 172 IFYPSMSAVVTWFFRRR--ALALGITASGSSLGGVIFPIMVERLIPQVGfGWTMricAFLILGLMVVANLTIV 242
Cdd:cd17319 287 AASPVFWSLPADLLPGEaaATAGGLINSGGNLGGFVAPLLIGYLVDATG-SYTA---AFLFLAAVALLAALLV 355
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
186-420 |
9.15e-04 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 41.53 E-value: 9.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 186 RRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFLILG---LMVVANLTIVSRIPPRPTPVRPK-----DF 257
Cdd:pfam13347 138 YRSFFSVGGGLLAAALAFPLVLILGGTGLERKGYRIFALIGAVLMLLgviITAAGTKERVSMRSKEDTGQKEAgslldML 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 258 VVPFKEVSFSLLALGSFLTFLGLFLpfTFIIVTARARHV--SPHLQKYLVSILNAASTFGRTIPPFYADRVG-RFTVFLS 334
Cdd:pfam13347 218 KEVFRNRAFLILLASFLLAALAMGV--LNGLLLYYFRYVlgNGFAASAFPLVFTIGALLGIPLWPPLAKRIGkKNTYILG 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 335 MSLLCALITLCLWLPGSGEAATIVFAVLYGFGSGAVASILPACIAHI--SHIHQIGVR-TGVLFSVVA----IAVLIGSP 407
Cdd:pfam13347 296 ALITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVvdYGELRTGKRrEGTFFAMWSfiskLATGVGLG 375
|
250
....*....|...
gi 378732173 408 IGGQLITNRGYRS 420
Cdd:pfam13347 376 VSGLLLSAFGYNA 388
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
99-249 |
1.08e-03 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 41.25 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 99 SSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFfhVFGL--MMASISTTYYqFLLSQGVCSALGASMIFYPS 176
Cdd:PRK14995 39 SGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGT--LFGLasLAAAFSPTAS-WLIATRALLAIGAAMIVPAT 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 378732173 177 MSAVVTWFF--RRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFLILgLMVVANLTIVSRIPPRP 249
Cdd:PRK14995 116 LAGIRATFTeeKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVL-VVMGLTARYVPRQAGRR 189
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
93-442 |
1.16e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 41.11 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 93 HQLKEYSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVCsALGASMI 172
Cdd:cd17312 30 VEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN-GLFQSMG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 173 FYPSMSAVVTWFFRR-RALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFlilgLMVVANLTIVSRIPPRPTP 251
Cdd:cd17312 109 WPPCVKLLGNWFSKKeRGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGI----VGLVVAIILFFFLRDSPPY 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 252 VRPKDFVVPF-KEVSFsllalgSFLTFLGLFLpftfiivtARARHVSPHLQKYLVSILNAASTFGRTIPPFYADRVG--- 327
Cdd:cd17312 185 VWVLSLAYAFvYIVRY------ACLDWGPLYL--------YEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFggr 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 328 RFTVFLSMSLLCALITLCLWLPGSGEAATIVFAVLYGFGSGAVASILPACIAHISHIHQIgvrTGVLFSVVAIAVLIGSP 407
Cdd:cd17312 251 RAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEA---AGTATGFVGLFGYLGAS 327
|
330 340 350
....*....|....*....|....*....|....*....
gi 378732173 408 IGGQLITnrGYRSMQGFSGGML----AAGFGVYLVLWLR 442
Cdd:cd17312 328 LAGLPLG--YIIDHYGWSTVFYflisAALLSVLLLLSLW 364
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
98-435 |
1.69e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.62 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 98 YSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVCSAlGASMIFYPSM 177
Cdd:cd17477 28 VSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGI-GLAGLFVVSE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 178 SAVVTWFFRR-RALALGITASGSSLGGVIFPIMVeRLIPQVGFGWTMRICAFLILGLMVVANLTIVSRIPPRPTPVRPKD 256
Cdd:cd17477 107 SWLNALATNEnRGRVLGLYSTVLGLGFALGPLLL-ALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRR 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 257 FVVPFKevsfsLLALGSFLTFLGLFLPFTFIIVTARARHVSPHLqkylVSILNAASTFGRTI--PPF--YADRVGRFTVF 332
Cdd:cd17477 186 LLRIAP-----LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQ----AALLLAAFVLGGLLlqWPLgwLADRFDRRRVL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 333 LSMSLLCALITLCLWLPGSGEAATIVFAVLYGfgsGAVASILPACIAHISHI---HQIGVRTGVLFSVVAIAVLIGSPIG 409
Cdd:cd17477 257 LGCALLGALAALLLPLVPGLPLALLVLLFLWG---GAAGPLYTLALALAGDRlpgDELVAANAALLLLYGLGSVIGPLLA 333
|
330 340
....*....|....*....|....*.
gi 378732173 410 GQLITNRGYRSMQGFSGGMLAAGFGV 435
Cdd:cd17477 334 GALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
188-437 |
2.44e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 39.92 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 188 RALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMR---ICAFLILG-LMVVANLTIVSRIPPRPTPVRPKD------- 256
Cdd:cd17313 139 RSKANGIINFMGGLGGVLGYLLGAILWDHNWFGFALGgnlKVPFYIGAiILLVCVLVTLFFVKEPPLSPEAGEhsenpsl 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 257 --FVVPFKEV------SFSLLALGSFLTFLGlFLPFTFIIVTARARHV----SPHLQKYLVS---------ILNAASTFG 315
Cdd:cd17313 219 geVLKSLLKLlkimprSLLRLLLVIFFWWIA-FFPFELFFTDYMGEEVyhgtSAASSHYGAGvrmgawgllIFSLAFLIF 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 316 RTIPPFYADRVGRFTVFLSMSLLCALITLCLWLPGSGEAATIVFAvLYGFGSGAVaSILP---ACIAHISHIHQIGVRTG 392
Cdd:cd17313 298 SLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFA-LGGIGWATI-NINPyplVSDYHSESGRGQGTDTG 375
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 378732173 393 VLFSVVAIAVLIGSPIGGQLITNRGYRSMQGFSGG-MLAAGFGVYL 437
Cdd:cd17313 376 LLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVaSFLSLVGALF 421
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
64-203 |
2.47e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.96 E-value: 2.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 64 TVVFGAACGLVVSFGWINCIGVFQEYYEthQLKEYSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVF 143
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQ--EVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 378732173 144 GLMMASISTTYYQFLLSQGVCSAlgASMIFYPSMSAVVTWFF--RRRALALGITASGSSLGG 203
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGF--GFGLLFPLLQALVAELAppEARGRASGLYNSAFFLGG 345
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
323-421 |
3.18e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.46 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 323 ADRVGR-------FTVFLSMSLLCALITLCLWLpgsgeaatIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLF 395
Cdd:cd17321 55 GDRFGRkrvfligLALFGLASLLCALAPSLAFL--------IAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWG 126
|
90 100
....*....|....*....|....*.
gi 378732173 396 SVVAIAVLIGSPIGGQLITNRGYRSM 421
Cdd:cd17321 127 AVVGIGAALGPLLGGLLLELFGWRWI 152
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
103-381 |
3.26e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 39.49 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 103 VAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSQGVCSALGASMI---FYPSMSA 179
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFtvgFVLGMEI 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 180 VVTwffRRRALALGITASGSSLGGVIFPIMVeRLIPQvgfgWTMRICAFLILGLMVVANLtivsripprptpvrpkdFVV 259
Cdd:cd17317 107 VGP---KYRSFVGILFGLFWALGYMLLALLA-YLIRD----WRWLQLAISLPGLLFLLLL-----------------WWL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 260 PFKEVSFSLLALGSFLTFLGLFLpftfiivtaRARHVSPHLqkYLVSILNAASTF-GRTIPPFYADRVGRFTVFLSMSLL 338
Cdd:cd17317 162 PRRTIIVGLIWFVTSLVYYGLSL---------NSSNLGGNL--YLNFFLSGLVEIpAYFLALLLLDRLGRRWTLSGSLLL 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 378732173 339 CALITLC-LWLPGSGEAATIVFAVLYGFGSGAVASILPACIAHI 381
Cdd:cd17317 231 AGLACLVtALLPDDENTLALTLALVGKFAISAAFSVIYLYTAEL 274
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
122-440 |
3.59e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 39.51 E-value: 3.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 122 GRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLS---QG------VCSALgasmifypsMSAVVTWFFRRRALAL 192
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGralQGsgaissVVMAL---------LADLTREENRTKAMAL 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 193 -----GITASGSSLGGvifPIMVERLipqvGFGWTMRICAFLILGLMVVanLTIVSRIPPRPTPVR---PKDFVVPFKEV 264
Cdd:cd17472 124 igasiGIAFAISMVLG---PLLAAHL----GVSGLFLITAILSLVSLLI--LLFFVPDPPKIVQISekeKKKLKKLLKNK 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 265 SFSLLALGSFLTFLGLFLPFtFIIVTARARHVSPHLQKYLVSILNAASTFGRTIP-PFYADRVGR-FTVFLSMSLLCALI 342
Cdd:cd17472 195 RLLRLDFSIFILHFVLMAFF-YILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPfVIYAEKKGKmKQVFVSSILLIAVG 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 343 TLCLWLPGSGEAATIVFAVLYGFGSGAVASILPACIAHISHIHQIGVRTGVLFSVVAIAVLIGSPIGGQLITNRGYRSMQ 422
Cdd:cd17472 274 FLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVF 353
|
330
....*....|....*...
gi 378732173 423 GFsGGMLAAGFGVYLVLW 440
Cdd:cd17472 354 LT-ILILALLWLLVSFLL 370
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
64-205 |
4.14e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.08 E-value: 4.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 64 TVVFGAACGLVVSFGWInCIGVFQEYYETHQLKeYSSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVF 143
Cdd:cd17321 169 TFSGAVLAAFLLGAALG-GLLFLLPLYLQGVLG-YSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAV 246
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 378732173 144 G---LMMASISTTYYQFLLSQGVCSaLGASMIFYPSMSAVVTWFFRRRA-LALGITASGSSLGGVI 205
Cdd:cd17321 247 GlllLALLGADSSVWLLLPGLVLLG-LGLGLFATPLTNAALSSVPKEKAgAASGILNTARQLGGAL 311
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
119-433 |
9.69e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 37.91 E-value: 9.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 119 LWVGRIYDNYGPR-SLLLTGTFFHVFGLMMASISTTYYQFLLSqgVCSALGASMIFYPSMSAVVTWFF-----RRRALAL 192
Cdd:cd17471 50 QWLGRLSDRGGDRkPLILLALLAGALGYLLFAFLRNYWVLLLV--GVVLLSLGAAAFPQLFALAREYAdrssgRDATLFN 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 193 GITASGSSLGGVIFPIMVERLIPQVGFGWTmricaFLILGLMVVANLTIVSRIPPRPTPVRPKDFVVPfkEVSFSLLALG 272
Cdd:cd17471 128 SVLRAAFSLAWVIGPPLAFLLLDVLGFTGL-----FLLAALLYLVVALLVLFLLPSVKPPAQKATPAS--SLVKAPVNRR 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 273 SFLTFLGLFLPFT--FIIVTARARHVS--PHLQKYLVSILnaastFGRT----IP-----PFYADRVGRFTVFLSMSLLC 339
Cdd:cd17471 201 LLLLFAAFTLLFAanSMYIIAMPLYVTneLGGSESWVGLL-----FGLAaaleIPimllaGLLAKRFGKRRLLLAGFLAG 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 340 ALITLCLWLpGSGEAATIVFAVLYGFGSGAVASILpaciahISHI-----HQIGVRTGVLFSVVAIAVLIGSPIGGQLIT 414
Cdd:cd17471 276 VLFYLGLAL-ATSLWQLIALQLLNAIFIGITAGLG------ISYFqdlmpGQPGLATTLYSNASRIGSLLGGLLAGVIAQ 348
|
330
....*....|....*....
gi 378732173 415 NRGYRSMQGFSGGMLAAGF 433
Cdd:cd17471 349 YFGYRAVFLVCAVLALLAL 367
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
99-237 |
9.89e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 37.91 E-value: 9.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378732173 99 SSQEVAWIPSLEAFMMFVGGLWVGRIYDNYGPRSLLLTGTFFHVFGLMMASISTTYYQFLLSqGVCSALGASMIFYPSMS 178
Cdd:COG0738 244 SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIG-LALVGLGLSLMFPTIFS 322
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 378732173 179 AVVTWFFRRRALALGITASGSSLGGVIFPIMVERLIPQVGFGWTMRICAFLILGLMVVA 237
Cdd:COG0738 323 LALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLA 381
|
|
| |
