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Conserved domains on  [gi|378731684|gb|EHY58143|]
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mitogen-activated protein kinase kinase kinase, variant 3 [Exophiala dermatitidis NIH/UT8656]

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 88-547 7.65e-117

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 350.72  E-value: 7.65e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  88 TVAVSVFTFISPVSSAMIAPALAKLGEDLHMTRDIEIeLSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNL 167
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVAN-LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 168 GCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSS 247
Cdd:cd17323   80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 248 SALALGIQVVGLIWLkeshpptilrrrrdrlvketgntnlkvyipqpitpgqpaasgpdnnsnnstpkvllqpdkppsll 327
Cdd:cd17323  160 AIISGFCLILIFLFL----------------------------------------------------------------- 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 328 htigsafirpgrliatqPIVQVIALYMAYLFGVMYLLLATFSNIWSEVYHESRGIGGFNYISIAIGSFVGVFANFYYIDR 407
Cdd:cd17323  175 -----------------PIVLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDY 237

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 408 IYKHLKAKNGGVGRPEFRIPSMIVGSATVTVGLFWYGWSVQARIHWIMPNLGVAIFSAGTIGCLQSMQTYTVDSYTRYAA 487
Cdd:cd17323  238 YYRRLKKKNGGKPEPEARLPPAFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAA 317

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 488 SALAAVAIFRSLAGFAFPLFAPYMYKALDYGWGTSVLAFISIGIGfPAPFIFWLFGPKLR 547
Cdd:cd17323  318 SALAANTLVRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMI-PIPFIFYKYGKKIR 376
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 88-547 7.65e-117

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 350.72  E-value: 7.65e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  88 TVAVSVFTFISPVSSAMIAPALAKLGEDLHMTRDIEIeLSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNL 167
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVAN-LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 168 GCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSS 247
Cdd:cd17323   80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 248 SALALGIQVVGLIWLkeshpptilrrrrdrlvketgntnlkvyipqpitpgqpaasgpdnnsnnstpkvllqpdkppsll 327
Cdd:cd17323  160 AIISGFCLILIFLFL----------------------------------------------------------------- 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 328 htigsafirpgrliatqPIVQVIALYMAYLFGVMYLLLATFSNIWSEVYHESRGIGGFNYISIAIGSFVGVFANFYYIDR 407
Cdd:cd17323  175 -----------------PIVLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDY 237

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 408 IYKHLKAKNGGVGRPEFRIPSMIVGSATVTVGLFWYGWSVQARIHWIMPNLGVAIFSAGTIGCLQSMQTYTVDSYTRYAA 487
Cdd:cd17323  238 YYRRLKKKNGGKPEPEARLPPAFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAA 317

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 488 SALAAVAIFRSLAGFAFPLFAPYMYKALDYGWGTSVLAFISIGIGfPAPFIFWLFGPKLR 547
Cdd:cd17323  318 SALAANTLVRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMI-PIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
80-482 4.71e-34

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 132.02  E-value: 4.71e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  80 PSKTKWSFTVAVSVFTFISPVSSAMIAPALAKLGEDLHMTRDiEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSN 159
Cdd:COG2814    4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPA-QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 160 LWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTT 239
Cdd:COG2814   83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 240 WRWVFWSSSALALGIQVVGLIWLKESHPPtilrrrrdrlvketgntnlkvyipqpitpgqpaasgpdnnsnnstpkvllq 319
Cdd:COG2814  163 WRWVFLVNAVLALLALLLLLRLLPESRPA--------------------------------------------------- 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 320 pdKPPSLLHTIGSAFIRPGrliatqpiVQVIALYMAYLFGVMYLLLATFSNIWSEVYHESRGIGGFNYISIAIGSFVGVF 399
Cdd:COG2814  192 --ARARLRGSLRELLRRPR--------LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGAL 261

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 400 ANFYYIDRIYkhlkaknggvgrpefRIPSMIVGSATVTVGLFWYGWSVQArihWIMPnLGVAIFSAGTIGCLQSMQTYTV 479
Cdd:COG2814  262 LAGRLADRFG---------------RRRLLLIGLLLLALGLLLLALAGSL---WLLL-LALFLLGFGFGLLFPLLQALVA 322


                 ...
gi 378731684 480 DSY 482
Cdd:COG2814  323 ELA 325
MFS_1 pfam07690
Major Facilitator Superfamily;
91-505 3.41e-28

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 115.59  E-value: 3.41e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684   91 VSVFTFISPVSSAMIAPALAK-LGEDLHMTRDiEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGC 169
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPT-EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  170 GFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSA 249
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  250 LALGIQVVGLIWLKESHPPTILRRRRDRLVketgntnlkvyipqpitpgqpaasgpdnnsnnstpkvllqpdkppsllht 329
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLS-------------------------------------------------- 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  330 igsaFIRPGRLIATQPIvqVIALYMAYLFGVMYLLLATFSNIWSEVYHESRGIGGFNYISIAIGSFVGVFANFYYIDRIy 409
Cdd:pfam07690 190 ----LIVAWKALLRDPV--LWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL- 262

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  410 khlkaknggvgRPEFRIPSMIVGSATVTVGLFWYGWSVQARIHWIMpnlgVAIFSAGTIGCLQSMQTYTVDSY-TRYAAS 488
Cdd:pfam07690 263 -----------GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLA----LLLLGFGFGLVFPALNALVSDLApKEERGT 327

                         410
                  ....*....|....*..
gi 378731684  489 ALAAVAIFRSLAGFAFP 505
Cdd:pfam07690 328 ASGLYNTAGSLGGALGP 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
129-265 1.66e-25

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 101.96  E-value: 1.66e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  129 SIFILAYAVGPLFFGPASELW----GRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVW 204
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLtdrfGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 378731684  205 TAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALALGIQVVGLIWLKES 265
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
99-278 5.41e-15

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 76.88  E-value: 5.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  99 PVSSAMIAPALAKLGEDLHMTRDiEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEI 178
Cdd:PRK11102   4 PLAIDMYLPALPVIAADFGVSAG-SVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 179 FIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALALGIQVVG 258
Cdd:PRK11102  83 IYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALV 162

                        170       180
                 ....*....|....*....|
gi 378731684 259 LIWLKESHPPTilRRRRDRL 278
Cdd:PRK11102 163 FFFIPETLPKE--RRQPFHL 180
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 88-547 7.65e-117

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 350.72  E-value: 7.65e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  88 TVAVSVFTFISPVSSAMIAPALAKLGEDLHMTRDIEIeLSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNL 167
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVAN-LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 168 GCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSS 247
Cdd:cd17323   80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 248 SALALGIQVVGLIWLkeshpptilrrrrdrlvketgntnlkvyipqpitpgqpaasgpdnnsnnstpkvllqpdkppsll 327
Cdd:cd17323  160 AIISGFCLILIFLFL----------------------------------------------------------------- 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 328 htigsafirpgrliatqPIVQVIALYMAYLFGVMYLLLATFSNIWSEVYHESRGIGGFNYISIAIGSFVGVFANFYYIDR 407
Cdd:cd17323  175 -----------------PIVLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDY 237

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 408 IYKHLKAKNGGVGRPEFRIPSMIVGSATVTVGLFWYGWSVQARIHWIMPNLGVAIFSAGTIGCLQSMQTYTVDSYTRYAA 487
Cdd:cd17323  238 YYRRLKKKNGGKPEPEARLPPAFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAA 317

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 488 SALAAVAIFRSLAGFAFPLFAPYMYKALDYGWGTSVLAFISIGIGfPAPFIFWLFGPKLR 547
Cdd:cd17323  318 SALAANTLVRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMI-PIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
80-482 4.71e-34

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 132.02  E-value: 4.71e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  80 PSKTKWSFTVAVSVFTFISPVSSAMIAPALAKLGEDLHMTRDiEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSN 159
Cdd:COG2814    4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPA-QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 160 LWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTT 239
Cdd:COG2814   83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 240 WRWVFWSSSALALGIQVVGLIWLKESHPPtilrrrrdrlvketgntnlkvyipqpitpgqpaasgpdnnsnnstpkvllq 319
Cdd:COG2814  163 WRWVFLVNAVLALLALLLLLRLLPESRPA--------------------------------------------------- 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 320 pdKPPSLLHTIGSAFIRPGrliatqpiVQVIALYMAYLFGVMYLLLATFSNIWSEVYHESRGIGGFNYISIAIGSFVGVF 399
Cdd:COG2814  192 --ARARLRGSLRELLRRPR--------LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGAL 261

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 400 ANFYYIDRIYkhlkaknggvgrpefRIPSMIVGSATVTVGLFWYGWSVQArihWIMPnLGVAIFSAGTIGCLQSMQTYTV 479
Cdd:COG2814  262 LAGRLADRFG---------------RRRLLLIGLLLLALGLLLLALAGSL---WLLL-LALFLLGFGFGLLFPLLQALVA 322


                 ...
gi 378731684 480 DSY 482
Cdd:COG2814  323 ELA 325
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 95-268 8.83e-29

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 117.68  E-value: 8.83e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  95 TFISPVSSAMIAPALAKLGEDLHmTRDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATN 174
Cdd:cd17320    8 VALGPLAIDMYLPALPAIARDLG-ASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 175 KPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALALGI 254
Cdd:cd17320   87 IEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLL 166

                        170
                 ....*....|....
gi 378731684 255 QVVGLIWLKESHPP 268
Cdd:cd17320  167 LLLVLLFLPETLPE 180
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 80-275 1.10e-28

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 115.68  E-value: 1.10e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  80 PSKTKWSFTVAVSVFTFISPVSSAMIAPALAKLGEDLHMTRDiEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSN 159
Cdd:COG0477    8 PTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSA-QLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 160 LWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTT 239
Cdd:COG0477   87 LLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 378731684 240 WRWVFWSSSALALgIQVVGLIWLKESHPPTILRRRR 275
Cdd:COG0477  167 WRWIFLINAPLGL-LALVLRLRLPESRGLLLALLAL 201
MFS_1 pfam07690
Major Facilitator Superfamily;
91-505 3.41e-28

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 115.59  E-value: 3.41e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684   91 VSVFTFISPVSSAMIAPALAK-LGEDLHMTRDiEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGC 169
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPT-EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  170 GFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSA 249
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  250 LALGIQVVGLIWLKESHPPTILRRRRDRLVketgntnlkvyipqpitpgqpaasgpdnnsnnstpkvllqpdkppsllht 329
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLS-------------------------------------------------- 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  330 igsaFIRPGRLIATQPIvqVIALYMAYLFGVMYLLLATFSNIWSEVYHESRGIGGFNYISIAIGSFVGVFANFYYIDRIy 409
Cdd:pfam07690 190 ----LIVAWKALLRDPV--LWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL- 262

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  410 khlkaknggvgRPEFRIPSMIVGSATVTVGLFWYGWSVQARIHWIMpnlgVAIFSAGTIGCLQSMQTYTVDSY-TRYAAS 488
Cdd:pfam07690 263 -----------GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLA----LLLLGFGFGLVFPALNALVSDLApKEERGT 327

                         410
                  ....*....|....*..
gi 378731684  489 ALAAVAIFRSLAGFAFP 505
Cdd:pfam07690 328 ASGLYNTAGSLGGALGP 344
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 91-252 7.59e-26

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 109.18  E-value: 7.59e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  91 VSVFTFISPVSSAMIAPALAKLGEDLHMTrDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCG 170
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGAS-PSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 171 FATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSAL 250
Cdd:cd17321   80 LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159


                 ..
gi 378731684 251 AL 252
Cdd:cd17321  160 GL 161
2_A_01_02 TIGR00880
Multidrug resistance protein;
129-265 1.66e-25

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 101.96  E-value: 1.66e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  129 SIFILAYAVGPLFFGPASELW----GRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVW 204
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLtdrfGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 378731684  205 TAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALALGIQVVGLIWLKES 265
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 89-269 4.30e-24

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 104.19  E-value: 4.30e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  89 VAVSVFTFISPVSSAMIAPALAKLGEDLHMTrDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLG 168
Cdd:cd17474    2 YAVFFATLLAVLGVSIVDPILPAIAEALGAS-PAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 169 CGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKtTWRWVFWSSS 248
Cdd:cd17474   81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLA 159

                        170       180
                 ....*....|....*....|.
gi 378731684 249 ALALGIQVVGLIWLKESHPPT 269
Cdd:cd17474  160 ALIPVAFLAILFLLPEPKEKA 180
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 87-268 1.73e-23

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 102.24  E-value: 1.73e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  87 FTVAVSVFTFISpvSSAMIAPALAKLGEDLHMTrDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWN 166
Cdd:cd17324    2 LALALAAFAIGT--TEYVIQGLLPDIARDFGVS-VAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 167 LGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWS 246
Cdd:cd17324   79 LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA 158

                        170       180
                 ....*....|....*....|..
gi 378731684 247 SSALALGIqVVGLIWLKESHPP 268
Cdd:cd17324  159 IAVLALLA-ALLLWRLLPSLPP 179
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
80-262 2.20e-22

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 98.79  E-value: 2.20e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  80 PSKTKWSFTVAVSVFTFISPVSSAMIAPALAKLGEDLHMTRdIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSN 159
Cdd:COG2271    4 PSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSA-AQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 160 LWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTT 239
Cdd:COG2271   83 LLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG 162

                        170       180
                 ....*....|....*....|...
gi 378731684 240 WRWVFWSSSALALGIQVVGLIWL 262
Cdd:COG2271  163 WRAAFLILGLPGLLLALLRFWLL 185
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 91-282 1.43e-21

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 96.49  E-value: 1.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  91 VSVFTFISPVSSAMIAPALAKLGEDLHMTrDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCG 170
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGAS-VAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 171 FATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSAL 250
Cdd:cd17325   80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159

                        170       180       190
                 ....*....|....*....|....*....|..
gi 378731684 251 ALGIQVVGLIWLKESHPPTILRRRRDRLVKET 282
Cdd:cd17325  160 ALLALVLALLLLPEPRPPPNKRAVSAARLRSG 191
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 87-268 2.45e-21

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 95.91  E-value: 2.45e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684   87 FTVAVSVFTFISPVSSAMIAPALAKLGEDLHMTRDIeIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWN 166
Cdd:TIGR00710   6 FALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASI-VQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  167 LGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWS 246
Cdd:TIGR00710  85 LGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAF 164

                         170       180
                  ....*....|....*....|....
gi 378731684  247 SSalALGIQVVGLIW--LKESHPP 268
Cdd:TIGR00710 165 LS--LAGILLSALIFfiLPETLPY 186
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 95-245 5.92e-18

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 85.71  E-value: 5.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  95 TFISPVSSAMIAPALAKLGEDLHMTRDiEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATN 174
Cdd:cd17503    5 AFMAILDTTIVNVALPTIMGDLGASLD-TVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPN 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 378731684 175 KPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFW 245
Cdd:cd17503   84 LASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFY 154
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 103-252 1.06e-17

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 84.94  E-value: 1.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 103 AMIAPALAKLGEDLHMTrDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFR 182
Cdd:cd17504   13 TMLSPALPTIQREFGTS-AAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGR 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 378731684 183 FLAGAGGSA-PLAIggGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALAL 252
Cdd:cd17504   92 ALQGIGGAVfPLAF--ALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAV 160
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 105-245 1.43e-17

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 84.15  E-value: 1.43e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 105 IAPALAKLGEDLHmtrdieiELSL-----SIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIF 179
Cdd:cd17502   15 VATALPTIVAEFG-------GLSLvswvgTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLI 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 378731684 180 IFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFW 245
Cdd:cd17502   88 VGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFY 153
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 88-268 2.31e-16

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 81.66  E-value: 2.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684   88 TVAVSVFTFISPVSSAMIAPALAKLGEDLHMTRDiEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNL 167
Cdd:TIGR00711   4 TIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLS-QVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  168 GCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSS 247
Cdd:TIGR00711  83 LCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLIN 162

                         170       180
                  ....*....|....*....|.
gi 378731684  248 SALALGIQVVGLIWLKESHPP 268
Cdd:TIGR00711 163 VPIGIIVVVVAFFILPRDKPA 183
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 103-304 8.96e-16

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 79.32  E-value: 8.96e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  103 AMIAPALAKlgeDLHMTRdIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFR 182
Cdd:TIGR00895  37 GFAAPAISA---EWGLDP-VQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILR 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  183 FLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALALGIQVVGLIWL 262
Cdd:TIGR00895 113 FLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFL 192

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 378731684  263 KESHPPTILRRRRDRLVKETGNTNLKVYIPQPITPGQPAASG 304
Cdd:TIGR00895 193 PESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQG 234
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 129-277 1.80e-15

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 78.50  E-value: 1.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 129 SIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEE 208
Cdd:cd17371   41 TVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARH 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 378731684 209 RGKAMGI--------YTLAPILGPVVGPIAGGWIAekttWRWVFWSSSALALGIQVVGLiWLKEshPPTILRRRRDR 277
Cdd:cd17371  121 RGKALGYvqsgwavgWLLATLLAALLFPLLPPEIA----WRVLFLLGALPALLVLFIRR-FVKE--PPQWQAARAAR 190
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
82-264 2.30e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 78.00  E-value: 2.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  82 KTKWSFTVAVSVFTFISPVSSAMIAPALAKLGEDLHMTRDiEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLW 161
Cdd:COG2223    1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAA-QLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 162 YLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWR 241
Cdd:COG2223   80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159

                        170       180
                 ....*....|....*....|...
gi 378731684 242 WVFWSSSALALGIQVVGLIWLKE 264
Cdd:COG2223  160 NAFLILGILLLVVAVLAWLFLRD 182
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 91-531 2.98e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 77.47  E-value: 2.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  91 VSVFTFISPVSSAMIAPALAKLGEDLHMTrDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCG 170
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLS-ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 171 FATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAE--KTTWRWVFWSSS 248
Cdd:cd06174   80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 249 ALALGIQVVGLIWLKESHPPtilrrrrdrlvketgntnlkvyipqpitpgqpaasgpdnnsnnstPKVLLQPDKPPSLLH 328
Cdd:cd06174  160 ALALLAAILLLLVVPDPPES---------------------------------------------ARAKNEEASSKSVLK 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 329 TIGSAFIRPGRLIatqpivqvIALYMAYLFGVMYLLLATFSNIWSEVYHESRGIGGFNYISIAIGSFVGVFANFYYIDRI 408
Cdd:cd06174  195 LLKRVLKNPGLWL--------LLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRL 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 409 YKHLKAknggvgrpefripsMIVGSATVTVGLFWYGWSVQARIHWIMpnlgVAIFSAGTIGCLQSMQTYTVDSY-TRYAA 487
Cdd:cd06174  267 IGRKPL--------------LLIGLLLMALGLALLLLAPSLLLLLLL----LLLLGFGLGGLLPLSFALIAELFpPEIRG 328

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 378731684 488 SALAAVAIFRSLAGFAFPLFAPYMYkALDYGWGTSVLAFISIGI 531
Cdd:cd06174  329 TAFGLLNTFGFLGGAIGPLLAGFLL-AATFGLTGAFLVLAVLLL 371
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 85-263 3.38e-15

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 77.23  E-value: 3.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  85 WSFTVAVSVFTFISPVSSAMIAPALAKLGEDLHMTrDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLA 164
Cdd:cd17319    2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLS-PTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 165 WNLGCGFATNKPEIFIFRFLAGAGgSAPLAIGGGCISDVW-TAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWV 243
Cdd:cd17319   81 FTALTGFATSLTSLYVLRFLLGVA-EAGFFPGAIKALAEWfPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWA 159

                        170       180
                 ....*....|....*....|
gi 378731684 244 FWSSSALALgiqVVGLIWLK 263
Cdd:cd17319  160 FIIEGLLGL---LLAVLWWF 176
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
99-278 5.41e-15

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 76.88  E-value: 5.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  99 PVSSAMIAPALAKLGEDLHMTRDiEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEI 178
Cdd:PRK11102   4 PLAIDMYLPALPVIAADFGVSAG-SVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 179 FIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALALGIQVVG 258
Cdd:PRK11102  83 IYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALV 162

                        170       180
                 ....*....|....*....|
gi 378731684 259 LIWLKESHPPTilRRRRDRL 278
Cdd:PRK11102 163 FFFIPETLPKE--RRQPFHL 180
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 84-262 1.47e-14

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 75.31  E-value: 1.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  84 KWSFTVAVSVFTFISPVSSAMIAPALAKLGEDLHMTRDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYL 163
Cdd:cd17325  197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 164 AWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWV 243
Cdd:cd17325  277 VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP 356

                        170
                 ....*....|....*....
gi 378731684 244 FWSSSALALGIQVVGLIWL 262
Cdd:cd17325  357 FLAAAALLLLAAVLFLLLR 375
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 101-297 3.22e-13

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 71.45  E-value: 3.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 101 SSAMIAPALAKLGEDLHMTRDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFI 180
Cdd:cd17473   14 AGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 181 FRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEkTTWRWVFWsssALALGIQVVGLI 260
Cdd:cd17473   94 SRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFL---VYLLALPVLILV 169

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 378731684 261 WLKESHPptilrRRRDRLVKETGNTNLKVYIPQPITP 297
Cdd:cd17473  170 LLFLPEP-----ARKSKSAASPGAATAAALPWKRVLP 201
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 91-280 2.10e-12

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 68.77  E-value: 2.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  91 VSVFTFISPVSSAMIAPALAKLGEDLHMTrDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCG 170
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPLYAHDLGGS-EAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 171 FATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSAL 250
Cdd:cd17489   80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL 159

                        170       180       190
                 ....*....|....*....|....*....|
gi 378731684 251 ALGIQVVGLIwLKESHPPTILRRRRDRLVK 280
Cdd:cd17489  160 ALLALLLVFL-VKDPPPVAAEEAEAGTRAF 188
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 87-262 4.58e-12

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 67.67  E-value: 4.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  87 FTVAVSVFTFISPVSSAMIApaLAKLGEDLHMTRDiEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWN 166
Cdd:cd17476    1 ATISGAQLLNQAGLGSVIVI--LPIIGDSFGTSPN-QLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 167 LGCGFATNKPEIFIFRFLAGAGGSAPLAiggGCISDVWTAEERGK----AMGIYTLAPILGPVVGPIAGGWIAEKTTWRW 242
Cdd:cd17476   78 LIAGFSPNFIFFIICRALQGLGPAFLLP---NAMALLGRTYPPGPrkniVFSLFGATAPLGFALGGVFGGLFAQLAWWPW 154

                        170       180
                 ....*....|....*....|
gi 378731684 243 VFWSSSALALGIQVVGLIWL 262
Cdd:cd17476  155 IFWFLAILAAIVAVAAIFWT 174
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 96-263 2.10e-11

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 65.29  E-value: 2.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  96 FISPVSSAMIAPALAKLGEDLHMTRDIEIELSL--SIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFAT 173
Cdd:cd17330    6 FLDALGFGIVFPVLPFYVREFNKLGASGYYVGLlqSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 174 NKPEIFIFRFLAGAGGSApLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALALG 253
Cdd:cd17330   86 NLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALL 164

                        170
                 ....*....|
gi 378731684 254 IQVVGLIWLK 263
Cdd:cd17330  165 NLVLVLFFLP 174
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 105-270 7.85e-11

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 63.75  E-value: 7.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 105 IAPALAKLGEDLHMTRD-IEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRF 183
Cdd:cd17315   16 INGALLYIAKDLGFGLStSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRF 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 184 LAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTT--WRWVFWSSSALALgIQVVGLIW 261
Cdd:cd17315   96 LLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPgwWRLMFALAAVPAL-LQLLLMFF 174


                 ....*....
gi 378731684 262 LKESHPPTI 270
Cdd:cd17315  175 LPESRALLV 183
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 105-270 1.88e-10

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 62.68  E-value: 1.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 105 IAPALAKLGEDLHMTRDiEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFL 184
Cdd:cd17312   22 FSVAKPPIVEEIGLSKD-DLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 185 AGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALALGIQVVGLIWLKE 264
Cdd:cd17312  101 NGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRD 180


                 ....*.
gi 378731684 265 ShPPTI 270
Cdd:cd17312  181 S-PPYV 185
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 108-410 4.32e-10

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 61.62  E-value: 4.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  108 ALAKLGEDLHMTRDiEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGA 187
Cdd:TIGR00881  17 AMPYLVEEIGLSKT-DLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGI 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  188 GGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGP-IAGGWIAEKTTWRWVFWSSSALALgiqVVGLIWlkesh 266
Cdd:TIGR00881  96 FQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIAI---IVSLIC----- 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  267 pptilrrrrdrlvketgntnLKVYIPQPITPGQPaasgPDNNSNNSTPKVLLQPDKPPSLLHTIGSAFIRPGRLIatqpi 346
Cdd:TIGR00881 168 --------------------FLLLRDSPQSCGLP----PAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVL----- 218

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 378731684  347 vqvIALYMAYLF--GVMYLLLATFSNIWSEVYHESRGIGGFNYISIAIGSFVGVFANFYYIDRIYK 410
Cdd:TIGR00881 219 ---WYISLGYVFvyVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFN 281
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 130-285 6.59e-10

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 61.11  E-value: 6.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 130 IFILAYAVGPLFFGPA----SELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGAGGsAPLAIGGGCISDVWT 205
Cdd:cd17388   42 VLLALYALMQFIFAPIlgalSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITG-ATGAVAAAYIADVTP 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 206 AEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTwRWVFWSSSALALGIQVVGLIWLKESHPPTILRRRRDRLVKETGNT 285
Cdd:cd17388  121 PEQRARNFGLLGAAFGLGFIAGPALGGLLGEISP-RAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSL 199
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 104-269 6.89e-10

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 61.08  E-value: 6.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 104 MIAPALAKLGEDLHMTRDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRF 183
Cdd:cd17472   14 LVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 184 LAGAGgsaplAIGGGCISdvWTA-----EERGKAMGI----YTLAPILGPVVGPIaggwIAEKTTWRWVFWSSSALALGI 254
Cdd:cd17472   94 LQGSG-----AISSVVMA--LLAdltreENRTKAMALigasIGIAFAISMVLGPL----LAAHLGVSGLFLITAILSLVS 162

                        170
                 ....*....|....*
gi 378731684 255 QVVGLIWLKESHPPT 269
Cdd:cd17472  163 LLILLFFVPDPPKIV 177
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 95-269 8.88e-10

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 60.70  E-value: 8.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  95 TFISPVSSAMIAPALAK-LGEDLHMTRDIeIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFAT 173
Cdd:cd17329    8 SFLNRLGFFMVWPFMAIyLHQQLGLSASI-VGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 174 NKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEkTTWRWVFWSSSALALG 253
Cdd:cd17329   87 SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLL 165

                        170
                 ....*....|....*.
gi 378731684 254 IQVVGLIWLKESHPPT 269
Cdd:cd17329  166 AALVLLFLLPETRPKR 181
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
85-264 1.66e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 59.88  E-value: 1.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  85 WSFTVAVSVFTFISPVSSAMIAPALAKLGEDLHMTRdIEIELSLSIFILAYAVGPLFFGPASELWGRVR--LLQLSNLWY 162
Cdd:COG2271  180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSL-AQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLA 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 163 LAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRW 242
Cdd:COG2271  259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338

                        170       180
                 ....*....|....*....|..
gi 378731684 243 VFWSSSALALGIQVVGLIWLKE 264
Cdd:COG2271  339 AFLLLAALALLAALLALLLLRE 360
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 131-262 2.26e-09

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 59.56  E-value: 2.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 131 FILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERG 210
Cdd:cd17328   43 FIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRT 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 378731684 211 KAMGIYTLAPILGPVVGPIAGGWIAEKT-TWRWVFWSSSalALGIQVVGLIWL 262
Cdd:cd17328  123 RALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTG--VLGVLLAILLLL 173
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 86-276 2.53e-09

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 59.56  E-value: 2.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  86 SFTVAVSVFTFISPvssamiAPALAKLGEDLHmtRDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAW 165
Cdd:cd06179    4 CLAYFAQLFGVTLP------AAVLPFIVADLG--PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 166 NLGCGFATNKPEIFIFRFLAGAGGSAPLaIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKT--TWRWV 243
Cdd:cd06179   76 SIVAGTAKSVNMLIGGQALIGIGAGTQG-LGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWI 154

                        170       180       190
                 ....*....|....*....|....*....|...
gi 378731684 244 FWSSSALAlGIQVVGLIWLkeSHPPTILRRRRD 276
Cdd:cd06179  155 FYINAIFN-ALALILLFFF--YHPPPRPQLHGS 184
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 102-265 2.76e-09

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 59.12  E-value: 2.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 102 SAMIAPALAKLGEDLHMTrDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIF 181
Cdd:cd17359   17 TGVINGALPFLQTDFNLT-PFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 182 RFLAGaggsapLAIGGGC------ISDVWTAEERGKAMGIYTLAPILGPVV--------GPIAGGWIAEKTTWRWVFWSS 247
Cdd:cd17359   96 RIIGG------LAVGGASalvpmyIAEVAPAEIRGRLVSLNQLMIVFGQLLayivnyliANAGGADWLGAEGWRWMLGLE 169

                        170       180
                 ....*....|....*....|
gi 378731684 248 S--ALALGIqvvGLIWLKES 265
Cdd:cd17359  170 AipAILFLL---GMLFIPES 186
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
105-269 4.32e-09

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 58.73  E-value: 4.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 105 IAPALAKLGEDLHMTRdIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFL 184
Cdd:COG2807   37 VGPLLPEIRADLGLSA-TQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTAL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 185 AGAGgsapLAIGGGCISDV---WTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALALGIQVVGLIW 261
Cdd:COG2807  116 IGAG----IAVGNVLLPGLikrWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPL 191


                 ....*...
gi 378731684 262 LKESHPPT 269
Cdd:COG2807  192 LRRRPAAA 199
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 105-252 8.33e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 57.61  E-value: 8.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 105 IAPALAKLGEDLhmTRDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFL 184
Cdd:cd17316   21 VAPVLAAEFSLG--LSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFL 98

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 378731684 185 AGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTT----WRWVFWSSSALAL 252
Cdd:cd17316   99 QGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILFLIGALPAL 170
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 105-245 1.45e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 56.82  E-value: 1.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 105 IAPALAKlgeDLHMTRDiEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFL 184
Cdd:cd17365   21 VAPALAQ---DWGLSPA-QLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFL 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 378731684 185 AGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFW 245
Cdd:cd17365   97 TGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFL 157
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 82-257 1.46e-08

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 56.81  E-value: 1.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  82 KTKWSFTVAVSVFTFI---------SPVSSAMIAPALAklgedlhmtrdIEIELSLSIFILAYAVGPLFFGPASEL-WGR 151
Cdd:cd17474  196 RGRGLLTFLVSAFLYFflyfafltyLPFLLELLYGISP-----------IIIGLLFAGWSVLLALGSLFVGRLLKKrFGA 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 152 VRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAG 231
Cdd:cd17474  265 RRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLF 344

                        170       180
                 ....*....|....*....|....*.
gi 378731684 232 GWIAEKTTWRWVFWSSSALALGIQVV 257
Cdd:cd17474  345 GLLLEIFGLSAPFLVGAAIALAAAVL 370
Sugar_tr pfam00083
Sugar (and other) transporter;
126-277 2.17e-08

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 56.51  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  126 LSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKP---EIFIFRFLAGaggsapLAIGGGC--- 199
Cdd:pfam00083  50 LIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWsvyQLIVGRVLVG------IGVGGASvla 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  200 ---ISDVWTAEERGKAMGIYTLAPILGPVVGPIAG---GWIAEKTTWRWVFWSSSALALgIQVVGLIWLKESHPPTILRR 273
Cdd:pfam00083 124 pmyISEIAPKKLRGALGSLYQLAITFGILLAYIFGlglNKTSNSDGWRIPLGLQLVPAL-LLIIGLLFLPESPRWLVEKG 202


                  ....
gi 378731684  274 RRDR 277
Cdd:pfam00083 203 RLEE 206
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 95-280 4.83e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 55.26  E-value: 4.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  95 TFISPVSSAMIAPALAKLGEDLHMTrDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATN 174
Cdd:cd17477    5 VALLGLGSGLLLPLLSLRLEREGVS-TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 175 KPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEkTTWRWVFWSSSALALGI 254
Cdd:cd17477   84 PWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGT-AGALPFLIAAVLLLLAL 162

                        170       180
                 ....*....|....*....|....*.
gi 378731684 255 QVVGLIWLKESHPPTILRRRRDRLVK 280
Cdd:cd17477  163 VPLLLTRRAAPEIEEAESISLRRLLR 188
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 96-269 6.72e-08

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 54.94  E-value: 6.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  96 FISPVSSAMIAPALAKLG----EDLHMTRdIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGF 171
Cdd:cd17475    2 TLAQAAASLVAQGIPALApflqEDLHLSL-AQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 172 ATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALA 251
Cdd:cd17475   81 VGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVS 160

                        170
                 ....*....|....*...
gi 378731684 252 LGIQVVGLIWLKESHPPT 269
Cdd:cd17475  161 ILAAVLFWLFYREPPAAS 178
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 95-299 9.18e-08

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 54.27  E-value: 9.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684   95 TFISPVSSAMIAPALAKLGEDLHMTrDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATN 174
Cdd:TIGR00893   3 TVINYLDRANLSFAAPMLQEDLGLS-AAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  175 KPEIFIFRFLAGAGgSAPLAIGGGCISDVW-TAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALALG 253
Cdd:TIGR00893  82 YVSLYILRVLLGAA-EAPFFPGIILIVASWfPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 378731684  254 IQVVGLIWLKES-HPPTILRRRRDRLVKETGNTNLKVYIPQPITPGQ 299
Cdd:TIGR00893 161 WGVLWLKFIPDPpQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPKKYQ 207
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
104-268 2.53e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 52.97  E-value: 2.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 104 MIAPALAKLGEDLHmTRDIEIELSLSIFILAYAVGPLFFGPASELWGR--VRLLQLSnLWYLAwNLGCGFATNKPEIFIF 181
Cdd:PRK11043  24 MYLPAFKAIQADLQ-TSASAVSASLSLFLAGFALGQLLWGPLSDRYGRkpVLLAGLS-LFALG-SLGMLWVESAAQLLVL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 182 RFLAGAGGSAPLAIgggcisdvWTA-----EERGKAMGIY-TLAPI--LGPVVGPIAGGWIAEKTTWRWVFWSSSALALG 253
Cdd:PRK11043 101 RFVQAVGVCSAAVI--------WQAlvidrYPAQKANRVFaTIMPLvaLSPALAPLLGAWLLNHFGWQAIFATLFAITLL 172

                        170
                 ....*....|....*
gi 378731684 254 IQVVGLiWLKESHPP 268
Cdd:PRK11043 173 LILPTL-RLKPSKKA 186
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 88-252 8.61e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 51.27  E-value: 8.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  88 TVAVSVFTFISPVSSAMIAPALAKLGEDLHMTRDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAW-N 166
Cdd:cd06174  205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALgL 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 167 LGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWI-AEKTTWRWVFW 245
Cdd:cd06174  285 ALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFL 364


                 ....*..
gi 378731684 246 SSSALAL 252
Cdd:cd06174  365 VLAVLLL 371
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 95-281 1.63e-06

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 50.34  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  95 TFISPVSSAMIAPALAKLGEDLHMTRDIEIELSLSIfilAYAVGPLFFGPASELWGRV------RLLQLSNLWYLAWNLG 168
Cdd:cd17391    5 NFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELWSGL---AFSSTFLVSAIFSPIWGRLadrygrKPMLLRASLGMAIVIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 169 C-GFATNKPEIFIFRFLAGA-GGSAPLAIGggCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWS 246
Cdd:cd17391   82 LmAFVTNVWQLLILRLLQGVfSGYVPNATA--LIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFI 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 378731684 247 SSALALGIQVVGLIWLKESHPPtiLRRRRDRLVKE 281
Cdd:cd17391  160 TGGLLFLAFLLTLFFVKEDFKP--VEKKKMVSTKE 192
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
87-276 1.88e-06

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 50.32  E-value: 1.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  87 FTVAVSVFTFISPVSSAMIAPALaklgedLHMTRDIEIEL-----SLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLW 161
Cdd:PRK15402  14 FPLCLVLFEFATYIANDMIQPGM------LAVVEDFNAGAewvptSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAF 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 162 YLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWtaEERG--KAMGIYTLAPILGPVVGPIAGGWIAEKTT 239
Cdd:PRK15402  88 FILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESF--EEADaiKITALMANVALLAPLLGPLVGAALIHVLP 165

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 378731684 240 WRWVFWSSSALALgiqvVGLIWLKESHPPTILRRRRD 276
Cdd:PRK15402 166 WRGMFVLFAALAA----LSFFGLWRAMPETAGRVGEK 198
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 105-272 2.10e-06

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 49.96  E-value: 2.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 105 IAPALAKLGEDL--HMTRDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFR 182
Cdd:cd17360   16 ISGALLYIKDDLgeVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGR 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 183 FLAGaggsapLAIGGGC------ISDVWTAEERGKAMGIYTLAPILGPVVGP-IAGGWIAEKTTWRWVFWSSSALALgIQ 255
Cdd:cd17360   96 VLVG------LGVGIASmtvplyIAEAAPPRIRGRLVTINVLFITGGQFVAYvINGAFSYLPGGWRWMLGLAAVPAV-LQ 168

                        170
                 ....*....|....*....
gi 378731684 256 VVGLIWLKES--HPPTILR 272
Cdd:cd17360  169 FIGLLFLPESprWPSTRRA 187
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 96-282 2.50e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 49.86  E-value: 2.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  96 FISPVSSAMIAPALAKLGEDLHMTrDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNK 175
Cdd:cd17478    6 FLNDFYQGFLPALLPLLIAKLGLS-YAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 176 PEIFIFRFLAGAGGSAPLAIGGGCISDVwTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWsssALALGIQ 255
Cdd:cd17478   85 WLLLLLVALAGIGSAAFHPEGARLASQA-AGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLI---LLIIPGL 160

                        170       180
                 ....*....|....*....|....*..
gi 378731684 256 VVGLIWLKESHPPTILRRRRDRLVKET 282
Cdd:cd17478  161 AVALLLLRLRPLKKPEAKKAAAKSSAR 187
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 70-252 6.63e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 48.31  E-value: 6.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  70 PDDPENPKNWPSKTKWS-----FTVAVSVFTFiSPVSSAMIAPALAKLGedlhmTRDIEIELSLSIFILAYAVGPLFFGP 144
Cdd:cd17370  183 PPKLRKKSKKTSLKKLPkafwlYLLAVALFAL-GNFSFAFLILRAQELG-----LSAALIPLLYALFNLVYALAAYPAGR 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 145 ASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGP 224
Cdd:cd17370  257 LSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGW 336

                        170       180
                 ....*....|....*....|....*...
gi 378731684 225 VVGPIAGGWIAEKTTWRWVFWSSSALAL 252
Cdd:cd17370  337 LLASLIAGYLWDLISPSAAFLFSAVLAL 364
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 87-276 7.42e-06

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 48.34  E-value: 7.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  87 FTVAVSVFTFISPVSsaMIAPALAKLGEDLHMTRDIEI-ELSL--SIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYL 163
Cdd:cd17358    5 FVANLGSFSFGIAVG--WSSPALPSLMSDNSLSLPLTVaQFSWfgSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 164 AWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAekttWRWV 243
Cdd:cd17358   83 LGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP----WRTL 158

                        170       180       190
                 ....*....|....*....|....*....|...
gi 378731684 244 FWSSSALALgIQVVGLIWLKEShPPTILRRRRD 276
Cdd:cd17358  159 ALIGAIPPV-VFLILLFFIPES-PRWLAKKGRE 189
emrD PRK11652
multidrug transporter EmrD;
104-274 9.90e-06

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 47.98  E-value: 9.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 104 MIAPALAKLGEDLHMtRDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRF 183
Cdd:PRK11652  26 IYVPAIADMARDLNV-REGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 184 LAGAG-GSAplaiGGGCIS---DVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALALGIQVVGL 259
Cdd:PRK11652 105 IQGLGtGVG----GVMARTlprDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMA 180

                        170
                 ....*....|....*
gi 378731684 260 IWLKESHPPTILRRR 274
Cdd:PRK11652 181 RWMPETRPADARRTR 195
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 113-301 1.30e-05

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 47.73  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 113 GEDLHMTRDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGAGGSap 192
Cdd:cd17362   30 GTDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIG-- 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 193 LAIGGGC--ISDVWTAEERGKAMGIYTLAPILGPVVGPIAG-GWIAEKTTWRWVFWSSSALALgIQVVGLIWLKEShpPT 269
Cdd:cd17362  108 LAMHAAPvyIAETSPSHIRGLLVSLKELFIVLGILLGYVSGyAFADVVGGWRYMYGLAAPPAL-LLGIGMWFLPPS--PR 184

                        170       180       190
                 ....*....|....*....|....*....|..
gi 378731684 270 ILRRRRDRLVKETGntnlkVYIPQPITpGQPA 301
Cdd:cd17362  185 WQGNYRKPLIIGLG-----LVLFQQIT-GQPS 210
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 121-262 1.90e-05

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 47.22  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 121 DIEIELSLSIFILAYAVGPLFFG-PASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAI-GGG 198
Cdd:cd17490  229 SFQLGLLSIIYLLPNALASLLSGtLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLlMSL 308

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 378731684 199 CISDVwTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALALGIQVVGLIWL 262
Cdd:cd17490  309 SIEGV-PAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 126-252 3.08e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 46.43  E-value: 3.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 126 LSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWT 205
Cdd:cd17489  231 LFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVP 310

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 378731684 206 AEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALAL 252
Cdd:cd17489  311 PHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVL 357
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
84-219 3.10e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.12  E-value: 3.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  84 KWSFTVAVSVFTFISPVSSAMIAPALAKLGEDLHMTRDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYL 163
Cdd:COG2814  205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 378731684 164 AWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLA 219
Cdd:COG2814  285 LGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
99-267 3.45e-05

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 46.17  E-value: 3.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  99 PVSSAMIAPALAKLGEDLHMTrDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEI 178
Cdd:PRK10473  16 PAGIDMYLVGLPRIAADLNAS-EAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLF 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 179 FIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAM----GIYTLAPILGPVVGPIaggwIAEKTTWRWVFWSSSALALGI 254
Cdd:PRK10473  95 LAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLsllnGITCIIPVLAPVLGHL----IMLKFPWQSLFYTMAAMGILV 170

                        170
                 ....*....|...
gi 378731684 255 QVVGLIWLKESHP 267
Cdd:PRK10473 171 LLLSLFILKETRP 183
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 91-236 3.47e-05

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 46.07  E-value: 3.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  91 VSVFTFISPVSSAMIAPALAKLGEDLHMTrdieiELSLSIFILAYAVGPLFFGPA----SELWGRVRLLQLSNLWYLAWN 166
Cdd:cd17390    1 LYLVGFLDLFGVSMILPLLSTHIRSLGAS-----PTVIGLIGSVYGALQLFSSPLvgswSDVVGRRPVLLICLLLTALGY 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 378731684 167 LGCGFATNKPEIFIFRFLAGA-GGSapLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAE 236
Cdd:cd17390   76 VLLGFSTSLALLFLSRIPLGIfKHT--QSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAE 144
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
70-268 3.69e-05

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 46.07  E-value: 3.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  70 PDDPENPKNWpsktKWSFTVAvSVFTFISPVSSAMIAPALA----KLGEDLHMTRDIEIELSLSIFILAYAVGPLFFGPA 145
Cdd:PRK09874   3 PCENDTPINW----KRNLTVA-WLGCFLTGAAFSLVMPFLPlyveQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 146 SELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGA-GGSAPLAigGGCISDVWTAEERGKAMGIYTLAPILGP 224
Cdd:PRK09874  78 ADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLlGGFVPNA--NALIATQVPRNKSGWALGTLSTGGVSGA 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 378731684 225 VVGPIAGGWIAEKTTWRWVFWSSSALALGIQVVGLIWLKESHPP 268
Cdd:PRK09874 156 LLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQP 199
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 123-277 4.34e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 46.11  E-value: 4.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 123 EIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGG-CIS 201
Cdd:cd17355   39 VISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFaTVA 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 378731684 202 DVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFwsssaLALGIQVVGLIwlkeshPPTILRRRRDR 277
Cdd:cd17355  119 AWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL-----LVLALLALLVL------VPVLLLLRRRP 183
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 129-267 4.61e-05

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 45.73  E-value: 4.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 129 SIF-ILAYAVGPLFfGPASELWGRVRLLQLSN----LWYLAWnlgcGFATNKPEIFIFRFLAG-AGGSAPLAIGggCISD 202
Cdd:cd17389   71 SLFsLLQFLSSPIT-GAASDVYGRKPVLLLTMiglaISYALW----AVSRSFTIFLLSRIVGGiSKGNVSLSTA--IVAD 143

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 378731684 203 VWTAEERGKAMGIYTLAPILGPVVGPIAGGWIA-EKTTWRWVFWSSSAL-ALGIQVVGLIW----LKESHP 267
Cdd:cd17389  144 VTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFAsFTRSLGEVFFSMPALfALVLALADLLFifffLPETLP 214
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
128-282 1.67e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.10  E-value: 1.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 128 LSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLA-GAGGSAPLAIGGGCISDVWTA 206
Cdd:COG2223  247 AALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLlGLALGGGNGAVFALVPDIFPT 326

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 378731684 207 EERGKAMGIYTLAPILGPVVGPIAGGWIAEKT-TWRWVFWSSSALALgiqvVGLIWlkeshppTILRRRRDRLVKET 282
Cdd:COG2223  327 KNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLAL----VALVL-------TLLLYRRPRRAAAA 392
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 79-263 1.81e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.14  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  79 WPSKTKWSFTVAVSVFTFISPVSSAMIaPALAKlgEDLHMTrDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLS 158
Cdd:cd06173  205 RRSPLLRLLLLALALFALLGGALTVLL-PLLAK--EVLGGG-AAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIG 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 159 NLWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKT 238
Cdd:cd06173  281 ALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360

                        170       180
                 ....*....|....*....|....*
gi 378731684 239 TWRWVFWSSSALALgiqVVGLIWLK 263
Cdd:cd06173  361 GLSAVFLLAGALLL---LAALLLLL 382
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 79-263 2.85e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 43.41  E-value: 2.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  79 WPSKTKWSFTVAVSVFTFISPVSSAMIAPALAKLGEDLhMTRDIEIELSLSIFILAYAVGPLFFGPaseLWGRV------ 152
Cdd:cd17391  194 WNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQL-MGDASNLAFISGLVFSATGVSSLLSAP---RLGKLgdrigh 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 153 -RLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAG 231
Cdd:cd17391  270 hRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLG 349

                        170       180       190
                 ....*....|....*....|....*....|..
gi 378731684 232 GWIAEKTTWRWVFWSSSALALgiqvVGLIWLK 263
Cdd:cd17391  350 SAIAAHFGYRAVFVVTALLVL----LNAIWSF 377
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
87-272 3.46e-04

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 43.28  E-value: 3.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  87 FTVAVSVFTFISPVSSAMIAPALaklgedLHMTRDIEIELSL-----SIFILAYAVGPLFFGPASELWGRVRLLQLSNLW 161
Cdd:PRK15403  17 FPMALILYDFAAYLTTDLIQPGI------INVVRDFNADVSLapasvSLYLAGGMALQWLLGPLSDRIGRRPVLITGALI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 162 YLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWR 241
Cdd:PRK15403  91 FTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWK 170

                        170       180       190
                 ....*....|....*....|....*....|.
gi 378731684 242 WVFWSSSALALgIQVVGLIWlkeSHPPTILR 272
Cdd:PRK15403 171 VLFAIIAVMGL-IAFVGLLL---AMPETVKR 197
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 87-261 4.25e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 42.92  E-value: 4.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  87 FTVAVSVFTFISPVssamiapalakLGEDLHMtRDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWN 166
Cdd:cd17324  211 FGGFFALYTYLAPF-----------LTDVPGF-SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALL 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 167 LGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVwTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWs 246
Cdd:cd17324  279 LLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGW- 356

                        170
                 ....*....|....*
gi 378731684 247 ssaLALGIQVVGLIW 261
Cdd:cd17324  357 ---VGAALLLLALLL 368
PRK10504 PRK10504
putative transporter; Provisional
 167-244 8.82e-04

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 42.03  E-value: 8.82e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 378731684 167 LGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVF 244
Cdd:PRK10504  90 LFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIF 167
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 95-277 1.07e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 41.54  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  95 TFISPVSSAMIAPALAKLGEDL----HMTRDiEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCG 170
Cdd:cd17333    1 LYISFFSNGLTDALLGILGPSLeeafNLNVA-DVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 171 FATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTaEERGKAMGI----YTLAPILGPvvgPIAGGWIAEKTTWRWVFWS 246
Cdd:cd17333   80 ATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVlhgfFGLGALIGP---LIATSLLTSELSWSWAYLI 155

                        170       180       190
                 ....*....|....*....|....*....|.
gi 378731684 247 SSALALGIQVVGLIWLKESHPPTILRRRRDR 277
Cdd:cd17333  156 IGLIYLLLAILILLTLFPELPSARNPQQSVG 186
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 121-277 1.51e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 41.09  E-value: 1.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 121 DIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNL--GCGFATNKPEIFIF-RFLAGAGGSAPLAIGG 197
Cdd:cd17357   48 DLLWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLlmFLSKSAKSPELLIFgRFLVGIACGLSTGFVP 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 198 GCISDVWTAEERGKAMGIYTLAPILGPVVGPIAG--GWIAEKTTWRWVFWSSSALALgIQVVGLIWLKEShPPTILRRRR 275
Cdd:cd17357  128 MYLQEISPSELRGALGSLTQIGVTLGILLGQVFGlpSVLGTETLWPYLLFFPGIPAL-LQLAALPFFPES-PKFLLISKG 205


                 ..
gi 378731684 276 DR 277
Cdd:cd17357  206 DE 207
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 126-259 1.62e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.05  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 126 LSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWY--LAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDV 203
Cdd:cd17316  217 LYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSgiLALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 378731684 204 WTAEERGKAMGI-YTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALALGIQVVGL 259
Cdd:cd17316  297 FPTEVRATGVGLsYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
80-254 2.06e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.61  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  80 PSKTKWSFTVAVSVFTFISPVSSAMIAPALAKLGEDLHMTrDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSN 159
Cdd:COG0738    2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLS-DAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 160 LWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVwTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEK-- 237
Cdd:COG0738   81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL-GPETAASRLNLLHAFFSLGALLGPLLGGLLILLgl 159

                        170
                 ....*....|....*...
gi 378731684 238 -TTWRWVFWSSSALALGI 254
Cdd:COG0738  160 sLSWHLPYLILAVLLLLL 177
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
126-234 3.11e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 40.27  E-value: 3.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 126 LSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFA--TNKPEIFIFRFLAGAGGSAPLAIGGGCISDV 203
Cdd:COG2211  268 LLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADV 347

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 378731684 204 -----WTAEER--GKAMGIYTLAPILGPVVGPIAGGWI 234
Cdd:COG2211  348 vdydeWKTGRRreGLYFGIFTFAIKLGQALAGALAGLL 385
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 115-252 3.16e-03

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 39.87  E-value: 3.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 115 DLHMTRDIEIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGAgGSAPLA 194
Cdd:cd17317   18 DLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGV-TSAGIF 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 378731684 195 IGGGCISDVWTAEERGKAMGIYTLAP-ILGPVVGPIAGGWIaekTTWRWVFWSSSALAL 252
Cdd:cd17317   97 TVGFVLGMEIVGPKYRSFVGILFGLFwALGYMLLALLAYLI---RDWRWLQLAISLPGL 152
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 138-244 3.27e-03

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 40.07  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 138 GPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGAGGSAPLAIGGGCISDVWTAEERGKAMGIYT 217
Cdd:PRK03893  71 GGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLI 150

                         90       100
                 ....*....|....*....|....*..
gi 378731684 218 LAPILGPVVGPIAGGWIAEKTTWRWVF 244
Cdd:PRK03893 151 SGFSIGAVVAAQVYSLVVPVWGWRALF 177
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 86-280 4.21e-03

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 40.04  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684   86 SFTVAVSVFTFISPVSSAMIAPALAKLGEDLHMTrdieieLSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAW 165
Cdd:pfam06609  48 AFSLNVCATYFVLQASASALPNILQDIGQSENQG------LFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVG 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  166 NL-GC---GFATNKPEIFIFRFLAGAGGSAPLAIGGgcisdvwTAEERGKAMGIYTL-AP-ILGPVVGPIAGGWIAEKTT 239
Cdd:pfam06609 122 AIvGCtanKFNTLLAAMTLLGVAAGPAGASPLFIGE-------LMSNKTKFLGLLIVsAPtIAMNGAGPYFGQRLAIQGN 194

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 378731684  240 WRWVFW---SSSALALGIQVvglIWLkesHPPTILR------RRRDRLVK 280
Cdd:pfam06609 195 WRWIFYiyiIMSAIAVLLII---IWY---HPPSFAQlhgkkaRKRDELAK 238
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 125-280 4.24e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 40.00  E-value: 4.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  125 ELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGAGGsaplaIGGGCISDVW 204
Cdd:TIGR00898 130 DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGI-----GGIWVQAVVL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  205 TAE-----ERGKAMGIYTLAPILGPVVGPIAGGWIAEkttWRWV-FWSSsaLALGIQVVGLIWLKESHPPTILRRRRDRL 278
Cdd:TIGR00898 205 NTEflpkkQRAIVGTLIQVFFSLGLVLLPLVAYFIPD---WRWLqLAVS--LPTFLFFLLSWFVPESPRWLISQGRIEEA 279


                  ..
gi 378731684  279 VK 280
Cdd:TIGR00898 280 LK 281
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 140-262 4.62e-03

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 39.57  E-value: 4.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 140 LFFGPASELWGRVRLLQLSNLWYLAWNLG----CGFATNKPEIFIFrflagaGGSAPLAI-GGGC---------ISDVWT 205
Cdd:cd17386   48 LFLGSWSDRYGRKPPLLMSLVGLLLSSLIlvliVYFTTVPSVWWFY------LSAIPLALfGGFTaflsasfayISDISS 121

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 378731684 206 AEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALAL-----GIQVVGLIWL 262
Cdd:cd17386  122 EKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLiallyILFFLTLLIL 183
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 92-248 5.36e-03

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 39.44  E-value: 5.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  92 SVFTFISPVSSAMIAPALAKLGEDLHMTRDIE---IELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLG 168
Cdd:cd17372    1 LAYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSawqVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 169 CGFATNKPEIFIFRFLAGAGgsaplaIGGGCISDVWTAE-----ERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWV 243
Cdd:cd17372   81 SAFAPNYMWLIILRCLVGLG------LGGGPQLASWYLEflpakSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWL 154


                 ....*
gi 378731684 244 FWSSS 248
Cdd:cd17372  155 LAFSS 159
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 128-291 5.69e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 39.12  E-value: 5.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 128 LSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFR----FLAGAGGSAplaiggGCISDV 203
Cdd:cd17331   41 QTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRlpsvFMHAMQAAQ------MVVTDL 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 204 WTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWSSSALALgIQVVGLIWLKESHPPTILRRRRDRLVKETG 283
Cdd:cd17331  115 TDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSL-LSIVLVILLIPSNTKSKREKEAKESASPPS 193


                 ....*...
gi 378731684 284 NTNLKVYI 291
Cdd:cd17331  194 VFNLKEIL 201
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 92-265 8.31e-03

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 38.64  E-value: 8.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684  92 SVFTFISPVSSAMIAPALAKLGEDLHMTRDI---EIELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLG 168
Cdd:cd17441    1 SILTGLAWMADAMEMMILSILAPQLHCEWRLpswQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGIL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 169 CGFATNKPEIFIFRFLAGAGgsaplaIGGGCISDVWTAE-----ERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWV 243
Cdd:cd17441   81 SAFAPIYSWILVLRGLVGFG------IGGVPQSVTLYAEflpmkSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWL 154

                        170       180
                 ....*....|....*....|..
gi 378731684 244 FwSSSALALGIQVVGLIWLKES 265
Cdd:cd17441  155 L-ILSALPLLIFAVLCFWLPES 175
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 108-262 9.06e-03

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 38.77  E-value: 9.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 108 ALAKLGEDLHMTRDiEIELSLSIFILAYAVGPLffgPASELWGRVRL---LQLSNLWYLAWNLGCGFATNKPEIFIFRFL 184
Cdd:cd17327   28 AVMGMKEDLKLVGN-QYNWGNTVFYVGYIIFEL---PGNLLLQRFPPskwLSVFIVLWGLLTLLTAAVKNFGGLIALRFF 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 185 AGAGGSAPLAIGGGCISDVWTAEERGKAMGIYTLAPILgpvvGPIAGGWIA----------EKTTWRWVFWSSSALALGI 254
Cdd:cd17327  104 LGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGL----GSIFGGLLAygvfkilgvgGLAGWRWLFIIEGLITIII 179


                 ....*...
gi 378731684 255 QVVGLIWL 262
Cdd:cd17327  180 GLVIFFWL 187
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 125-188 9.71e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 38.43  E-value: 9.71e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 378731684 125 ELSLSIFILAYAVGPLFFGPASELWGRVRLLQLSNLWYLAWNLGCGFATNKPEIFIFRFLAGAG 188
Cdd:cd17374   38 SVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFA 101
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 178-260 9.93e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 38.36  E-value: 9.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731684 178 IFIFRFLAGAGGSAPLAIgggCI--SDVWTAEERGKAMGIYTLAPILGPVVGPIAGGWIAEKTTWRWVFWsssaLALGIQ 255
Cdd:cd17490   88 LLIARFLSGIAAATWVSF---TVlyASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFL----LAALAG 160


                 ....*
gi 378731684 256 VVGLI 260
Cdd:cd17490  161 VLGFI 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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