NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|377947708|gb|EHV11373|]
View 

prophage tail fiber family protein [Escherichia coli DEC4C]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Peptidase_M14NE-CP-C_like super family cl21470
Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, ...
 1-141 6.52e-67

Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; This domain is found C-terminal to the M14 carboxypeptidase (CP) N/E subfamily containing zinc-binding enzymes that hydrolyze single C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. The N/E subfamily includes enzymatically active members (carboxypeptidase N, E, M, D, and Z), as well as non-active members (carboxypeptidase-like protein 1, -2, aortic CP-like protein, and adipocyte enhancer binding protein-1) which lack the critical active site and substrate-binding residues considered necessary for activity. The active N/E enzymes fulfill a variety of cellular functions, including prohormone processing, regulation of peptide hormone activity, alteration of protein-protein or protein-cell interactions and transcriptional regulation. For M14 CPs, it has been suggested that this domain may assist in folding of the CP domain, regulate enzyme activity, or be involved in interactions with other proteins or with membranes; for carboxypeptidase M, it may interact with the bradykinin 1 receptor at the cell surface. This domain may also be found in other peptidase families.


The actual alignment was detected with superfamily member pfam08400:

Pssm-ID: 473874  Cd Length: 134  Bit Score: 208.67  E-value: 6.52e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377947708    1 MAVKISGVLKDGTGKPVENCTIQLKARRNSATVVVNTVASENPDEAGRYSMDVEYGQYSVILLVEGFPPSHAGTITVYED 80
Cdd:pfam08400   1 MSVVISGVLKDGTGIPVQNCTIQLKARRTSTTVVVNTVASENPDNAGRYSMDVETGQYGVYLKVDGRPPSHAGDITVYED 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 377947708   81 SQPGTLNDFLGAMSEDDVRPEALRRFELMVeeaarhaEEAKKNAGEAETSARNAGISASQA 141
Cdd:pfam08400  81 SKPGTLNDFLIAMTEDDLRPEVLRRFEEMV-------EEVARSASAAAGNARQAAQDAGDA 134
Phage_fiber_C pfam06820
Putative prophage tail fibre C-terminus; This family represents the C-terminus of a prophage ...
 333-396 5.18e-33

Putative prophage tail fibre C-terminus; This family represents the C-terminus of a prophage tail fibre protein found mostly in E. coli. All family members contain a conserved RLGP motif.


:

Pssm-ID: 148432  Cd Length: 64  Bit Score: 118.49  E-value: 5.18e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 377947708  333 IRFRLGPGNIIETNSHGWFPDTDGALITGLTFLDPKDATRVQGFFQHLQVRFGDGPWQDVKGLD 396
Cdd:pfam06820   1 AQFRLGPADIIESDEHGIFPEQDGALITGLTFLADADKKQIQCFFQHLQILFADGPWEDIGGLD 64
gly_rich_SclB super family cl45768
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 265-339 1.13e-07

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


The actual alignment was detected with superfamily member NF038329:

Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 53.76  E-value: 1.13e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 377947708 265 QGPKGDKGERGDTGPAGATGERGPAGDAGPAGPAGPAGPQGPKGETGAAGPVGATGPQGPKGDPGETQIRFRLGP 339
Cdd:NF038329 137 RGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGP 211
 
Name Accession Description Interval E-value
phage_tail_N pfam08400
Prophage tail fibre N-terminal; This domain is found at the N-terminus of prophage tail fibre ...
 1-141 6.52e-67

Prophage tail fibre N-terminal; This domain is found at the N-terminus of prophage tail fibre proteins.


Pssm-ID: 285585  Cd Length: 134  Bit Score: 208.67  E-value: 6.52e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377947708    1 MAVKISGVLKDGTGKPVENCTIQLKARRNSATVVVNTVASENPDEAGRYSMDVEYGQYSVILLVEGFPPSHAGTITVYED 80
Cdd:pfam08400   1 MSVVISGVLKDGTGIPVQNCTIQLKARRTSTTVVVNTVASENPDNAGRYSMDVETGQYGVYLKVDGRPPSHAGDITVYED 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 377947708   81 SQPGTLNDFLGAMSEDDVRPEALRRFELMVeeaarhaEEAKKNAGEAETSARNAGISASQA 141
Cdd:pfam08400  81 SKPGTLNDFLIAMTEDDLRPEVLRRFEEMV-------EEVARSASAAAGNARQAAQDAGDA 134
Phage_fiber_C pfam06820
Putative prophage tail fibre C-terminus; This family represents the C-terminus of a prophage ...
 333-396 5.18e-33

Putative prophage tail fibre C-terminus; This family represents the C-terminus of a prophage tail fibre protein found mostly in E. coli. All family members contain a conserved RLGP motif.


Pssm-ID: 148432  Cd Length: 64  Bit Score: 118.49  E-value: 5.18e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 377947708  333 IRFRLGPGNIIETNSHGWFPDTDGALITGLTFLDPKDATRVQGFFQHLQVRFGDGPWQDVKGLD 396
Cdd:pfam06820   1 AQFRLGPADIIESDEHGIFPEQDGALITGLTFLADADKKQIQCFFQHLQILFADGPWEDIGGLD 64
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 265-339 1.13e-07

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 53.76  E-value: 1.13e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 377947708 265 QGPKGDKGERGDTGPAGATGERGPAGDAGPAGPAGPAGPQGPKGETGAAGPVGATGPQGPKGDPGETQIRFRLGP 339
Cdd:NF038329 137 RGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGP 211
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
 265-330 6.64e-05

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 40.17  E-value: 6.64e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 377947708  265 QGPKGDKGERGDTGPAGATGERgpagdagpagpaGPAGPQGPKGETGAAGPVGATGPQGPKGDPGE 330
Cdd:pfam01391   3 PGPPGPPGPPGPPGPPGPPGPP------------GPPGPPGEPGPPGPPGPPGPPGPPGAPGAPGP 56
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 265-329 1.31e-04

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 43.74  E-value: 1.31e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 377947708 265 QGPKGDKGERGDTGPAGATGErgpagdagpagpAGPAGPQGPKGETGAAGPVGATGPQGPKGDPG 329
Cdd:NF038329 235 QGPDGDPGPTGEDGPQGPDGP------------AGKDGPRGDRGEAGPDGPDGKDGERGPVGPAG 287
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 268-339 1.22e-03

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 40.66  E-value: 1.22e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 377947708 268 KGDkGERGDTGPAGATGERgpagdagpagpaGPAGPQGPKGETGAAGPVGATGPQGPKGDPGETQIRFRLGP 339
Cdd:NF038329 114 KGD-GEKGEPGPAGPAGPA------------GEQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGP 172
 
Name Accession Description Interval E-value
phage_tail_N pfam08400
Prophage tail fibre N-terminal; This domain is found at the N-terminus of prophage tail fibre ...
 1-141 6.52e-67

Prophage tail fibre N-terminal; This domain is found at the N-terminus of prophage tail fibre proteins.


Pssm-ID: 285585  Cd Length: 134  Bit Score: 208.67  E-value: 6.52e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377947708    1 MAVKISGVLKDGTGKPVENCTIQLKARRNSATVVVNTVASENPDEAGRYSMDVEYGQYSVILLVEGFPPSHAGTITVYED 80
Cdd:pfam08400   1 MSVVISGVLKDGTGIPVQNCTIQLKARRTSTTVVVNTVASENPDNAGRYSMDVETGQYGVYLKVDGRPPSHAGDITVYED 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 377947708   81 SQPGTLNDFLGAMSEDDVRPEALRRFELMVeeaarhaEEAKKNAGEAETSARNAGISASQA 141
Cdd:pfam08400  81 SKPGTLNDFLIAMTEDDLRPEVLRRFEEMV-------EEVARSASAAAGNARQAAQDAGDA 134
Phage_fiber_C pfam06820
Putative prophage tail fibre C-terminus; This family represents the C-terminus of a prophage ...
 333-396 5.18e-33

Putative prophage tail fibre C-terminus; This family represents the C-terminus of a prophage tail fibre protein found mostly in E. coli. All family members contain a conserved RLGP motif.


Pssm-ID: 148432  Cd Length: 64  Bit Score: 118.49  E-value: 5.18e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 377947708  333 IRFRLGPGNIIETNSHGWFPDTDGALITGLTFLDPKDATRVQGFFQHLQVRFGDGPWQDVKGLD 396
Cdd:pfam06820   1 AQFRLGPADIIESDEHGIFPEQDGALITGLTFLADADKKQIQCFFQHLQILFADGPWEDIGGLD 64
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 265-339 1.13e-07

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 53.76  E-value: 1.13e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 377947708 265 QGPKGDKGERGDTGPAGATGERGPAGDAGPAGPAGPAGPQGPKGETGAAGPVGATGPQGPKGDPGETQIRFRLGP 339
Cdd:NF038329 137 RGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGP 211
CarboxypepD_reg pfam13620
Carboxypeptidase regulatory-like domain;
5-87 4.45e-05

Carboxypeptidase regulatory-like domain;


Pssm-ID: 433354 [Multi-domain]  Cd Length: 81  Bit Score: 41.50  E-value: 4.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 377947708    5 ISGVLKDGTGKPVENCTIQLKARRNSATVVVNTvasenpDEAGRYSM-DVEYGQYSVILLVEGFPPSHAGTITVyEDSQP 83
Cdd:pfam13620   2 ISGTVTDPSGAPVPGATVTVTNTDTGTVRTTTT------DADGRYRFpGLPPGTYTVTVSAPGFKTATRTGVTV-TAGQT 74


                  ....
gi 377947708   84 GTLN 87
Cdd:pfam13620  75 TTLD 78
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
 265-330 6.64e-05

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 40.17  E-value: 6.64e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 377947708  265 QGPKGDKGERGDTGPAGATGERgpagdagpagpaGPAGPQGPKGETGAAGPVGATGPQGPKGDPGE 330
Cdd:pfam01391   3 PGPPGPPGPPGPPGPPGPPGPP------------GPPGPPGEPGPPGPPGPPGPPGPPGAPGAPGP 56
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 265-329 1.31e-04

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 43.74  E-value: 1.31e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 377947708 265 QGPKGDKGERGDTGPAGATGErgpagdagpagpAGPAGPQGPKGETGAAGPVGATGPQGPKGDPG 329
Cdd:NF038329 235 QGPDGDPGPTGEDGPQGPDGP------------AGKDGPRGDRGEAGPDGPDGKDGERGPVGPAG 287
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 268-339 1.22e-03

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 40.66  E-value: 1.22e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 377947708 268 KGDkGERGDTGPAGATGERgpagdagpagpaGPAGPQGPKGETGAAGPVGATGPQGPKGDPGETQIRFRLGP 339
Cdd:NF038329 114 KGD-GEKGEPGPAGPAGPA------------GEQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGP 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH