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Conserved domains on  [gi|363652681|gb|EHL91714|]
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hypothetical protein HMPREF1019_00103 [Campylobacter sp. 10_1_50]

Protein Classification

nucleotidyl cyclase domain-containing protein( domain architecture ID 34085)

nucleotidyl cyclase domain-containing protein may function as a mononucleotidyl cyclase (MNC) or a diguanylate cyclase (DGC)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nucleotidyl_cyc_III super family cl11967
Class III nucleotidyl cyclases; Class III nucleotidyl cyclases are the largest, most diverse ...
 17-120 1.77e-03

Class III nucleotidyl cyclases; Class III nucleotidyl cyclases are the largest, most diverse group of nucleotidyl cyclases (NC's) containing prokaryotic and eukaryotic proteins. They can be divided into two major groups; the mononucleotidyl cyclases (MNC's) and the diguanylate cyclases (DGC's). The MNC's, which include the adenylate cyclases (AC's) and the guanylate cyclases (GC's), have a conserved cyclase homology domain (CHD), while the DGC's have a conserved GGDEF domain, named after a conserved motif within this subgroup. Their products, cyclic guanylyl and adenylyl nucleotides, are second messengers that play important roles in eukaryotic signal transduction and prokaryotic sensory pathways.


The actual alignment was detected with superfamily member TIGR00254:

Pssm-ID: 448371 [Multi-domain]  Cd Length: 165  Bit Score: 36.55  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363652681   17 LEIAFIKRYKNVKDYAKNLSLIYFSLPNSKEY----------------GEIFEKILRQTDVVIR-ENEHYVVVLHGTNER 79
Cdd:TIGR00254  16 LEEMLDSELKRARRFQRSFSVLMIDIDNFKKIndtlghdvgdevlrevARILQSSVRGSDVVGRyGGEEFVVILPGTPLE 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 363652681   80 GASELLTGIQEFLNAEPIDL-------------VVTYPKDGKDAKELaIKLQDE 120
Cdd:TIGR00254  96 DALSKAERLRDAINSKPIEVagsetltvtvsigVACYPGHGLTLEEL-LKRADE 148
 
Name Accession Description Interval E-value
GGDEF TIGR00254
diguanylate cyclase (GGDEF) domain; The GGDEF domain is named for the motif GG[DE]EF shared by ...
 17-120 1.77e-03

diguanylate cyclase (GGDEF) domain; The GGDEF domain is named for the motif GG[DE]EF shared by many proteins carrying the domain. There is evidence that the domain has diguanylate cyclase activity. Several proteins carrying this domain also carry domains with functions relating to environmental sensing. These include PleD, a response regulator protein involved in the swarmer-to-stalked cell transition in Caulobacter crescentus, and FixL, a heme-containing oxygen sensor protein. [Regulatory functions, Small molecule interactions, Signal transduction, Other]


Pssm-ID: 272984 [Multi-domain]  Cd Length: 165  Bit Score: 36.55  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363652681   17 LEIAFIKRYKNVKDYAKNLSLIYFSLPNSKEY----------------GEIFEKILRQTDVVIR-ENEHYVVVLHGTNER 79
Cdd:TIGR00254  16 LEEMLDSELKRARRFQRSFSVLMIDIDNFKKIndtlghdvgdevlrevARILQSSVRGSDVVGRyGGEEFVVILPGTPLE 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 363652681   80 GASELLTGIQEFLNAEPIDL-------------VVTYPKDGKDAKELaIKLQDE 120
Cdd:TIGR00254  96 DALSKAERLRDAINSKPIEVagsetltvtvsigVACYPGHGLTLEEL-LKRADE 148
 
Name Accession Description Interval E-value
GGDEF TIGR00254
diguanylate cyclase (GGDEF) domain; The GGDEF domain is named for the motif GG[DE]EF shared by ...
 17-120 1.77e-03

diguanylate cyclase (GGDEF) domain; The GGDEF domain is named for the motif GG[DE]EF shared by many proteins carrying the domain. There is evidence that the domain has diguanylate cyclase activity. Several proteins carrying this domain also carry domains with functions relating to environmental sensing. These include PleD, a response regulator protein involved in the swarmer-to-stalked cell transition in Caulobacter crescentus, and FixL, a heme-containing oxygen sensor protein. [Regulatory functions, Small molecule interactions, Signal transduction, Other]


Pssm-ID: 272984 [Multi-domain]  Cd Length: 165  Bit Score: 36.55  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363652681   17 LEIAFIKRYKNVKDYAKNLSLIYFSLPNSKEY----------------GEIFEKILRQTDVVIR-ENEHYVVVLHGTNER 79
Cdd:TIGR00254  16 LEEMLDSELKRARRFQRSFSVLMIDIDNFKKIndtlghdvgdevlrevARILQSSVRGSDVVGRyGGEEFVVILPGTPLE 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 363652681   80 GASELLTGIQEFLNAEPIDL-------------VVTYPKDGKDAKELaIKLQDE 120
Cdd:TIGR00254  96 DALSKAERLRDAINSKPIEVagsetltvtvsigVACYPGHGLTLEEL-LKRADE 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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