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Conserved domains on  [gi|346324509|gb|EGX94106|]
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Major facilitator superfamily transporter [Cordyceps militaris CM01]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 63-448 1.20e-117

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17327:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 406  Bit Score: 351.55  E-value: 1.20e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  63 DRANIGNAKLAGLEADLNMEGYDYSIAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLA 142
Cdd:cd17327   20 DKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIA 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 143 VRSLLGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEMKGVGGLSGWNWIFILEGLATFVV 222
Cdd:cd17327  100 LRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVGGLAGWRWLFIIEGLITIII 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 223 ALIAYRVMHDYPETVKFLNPEQKKEVVRRLKQDRSALSN-EFKLSLAKDALKDWKIWVHMLITIGIYIPLYSISVFLPTI 301
Cdd:cd17327  180 GLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDqKFKWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLI 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 302 VKGLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQRGIYMIGFNLIAILGFALLAAVQSHGVKYFACFLVTVGVYPN 381
Cdd:cd17327  260 LKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLAAPNPPGAYFAAYILGGGSYAG 339

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 346324509 382 VPQGVAWNGNNIGGSLKRAVGIAMHVGFGNLGGAVSGFVFRQVEAPRYLSGHLALVGTLSMSLVLTI 448
Cdd:cd17327  340 FPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIFRAGDAPRYIPGNIALLVCACVSIVLSV 406
 
Name Accession Description Interval E-value
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 63-448 1.20e-117

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 351.55  E-value: 1.20e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  63 DRANIGNAKLAGLEADLNMEGYDYSIAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLA 142
Cdd:cd17327   20 DKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIA 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 143 VRSLLGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEMKGVGGLSGWNWIFILEGLATFVV 222
Cdd:cd17327  100 LRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVGGLAGWRWLFIIEGLITIII 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 223 ALIAYRVMHDYPETVKFLNPEQKKEVVRRLKQDRSALSN-EFKLSLAKDALKDWKIWVHMLITIGIYIPLYSISVFLPTI 301
Cdd:cd17327  180 GLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDqKFKWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLI 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 302 VKGLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQRGIYMIGFNLIAILGFALLAAVQSHGVKYFACFLVTVGVYPN 381
Cdd:cd17327  260 LKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLAAPNPPGAYFAAYILGGGSYAG 339

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 346324509 382 VPQGVAWNGNNIGGSLKRAVGIAMHVGFGNLGGAVSGFVFRQVEAPRYLSGHLALVGTLSMSLVLTI 448
Cdd:cd17327  340 FPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIFRAGDAPRYIPGNIALLVCACVSIVLSV 406
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 63-424 4.10e-46

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 165.20  E-value: 4.10e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509   63 DRANIGNAKLAgLEADLNMEGYDYSIAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLA 142
Cdd:TIGR00893   9 DRANLSFAAPM-LQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYI 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  143 VRSLLGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEMkgvgglSGWNWIFILEGLATFVV 222
Cdd:TIGR00893  88 LRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIH------FSWQWAFIIEGVLGIIW 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  223 ALIAYRVMHDYPETVKFLNPEQKKEVVRRLKQDRSALSN-EFKLSLAKDALKDWKIWVHMLITIGIYIPLYSISVFLPT- 300
Cdd:TIGR00893 162 GVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPsTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPTy 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  301 IVKGLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQRGIYMIGFNLIAILGFALLA----AVQSHGVKYFACFLVTV 376
Cdd:TIGR00893 242 LVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSllmfATNYVNIPYAALALVAL 321

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 346324509  377 GVYPNVPQGVAW-------NGNNIGGSlkravgiamhVGFGNLGGAVSGFVFRQV 424
Cdd:TIGR00893 322 GFFGLGAGAIGWalisdnaPGNIAGLT----------GGLINSLGNLGGIVGPIV 366
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
63-460 1.79e-35

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 135.38  E-value: 1.79e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  63 DRANIGNAKLAgLEADLNMEGYDYSIAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLA 142
Cdd:COG2271   25 DRSNLSVAAPP-LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 143 VRSLLGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEmkgvggLSGWNWIFILEGLATFVV 222
Cdd:COG2271  104 LRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA------AFGWRAAFLILGLPGLLL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 223 ALIAyrvmhdypetvkflnpeqkkevvrrlkqdrsalsnefklslakdalkdwkIWVHMLITIGIYIPLYSISVFLPTI- 301
Cdd:COG2271  178 ALLR--------------------------------------------------FWLLALAYFLVYFALYGFLTWLPTYl 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 302 VKGLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQRG-IYMIGFNLIAILGFALLAAVQSHGVKYFACFLVTVGVYP 380
Cdd:COG2271  208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGG 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 381 NVPQGVAWNGNNIGGSLkRAVGIAMHVGFGNLGGAVSGFVFRQVEApryLSGHLALVGTLSMSLVLTIFMTIYLRRENAR 460
Cdd:COG2271  288 AFGLLWALAAELFPKKA-RGTASGLVNTFGFLGGALGPLLVGYLLD---ATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_1 pfam07690
Major Facilitator Superfamily;
63-417 4.31e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 94.41  E-value: 4.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509   63 DRANIGNAKLAGLEADLNMEGYDYSIAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLA 142
Cdd:pfam07690  11 GRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  143 VRSLLGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEmkgvggLSGWNWIFILEGLATFVV 222
Cdd:pfam07690  91 LRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS------LFGWRAAFLILAILSLLA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  223 ALIAYrvmhdypetvkFLNPEQKKEVVRRLKQDRsalsnEFKLSLAKDALKDWKIWVhMLITIGIYIPLYSISVFLPTIV 302
Cdd:pfam07690 165 AVLLL-----------LPRPPPESKRPKPAEEAR-----LSLIVAWKALLRDPVLWL-LLALLLFGFAFFGLLTYLPLYQ 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  303 KGLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQRGIYMIGFNLIAI--LGFALLAAVQSHGVKYFACFLVTVGVYP 380
Cdd:pfam07690 228 EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILaaLGLLLLSLTLSSLWLLLALLLLGFGFGL 307

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 346324509  381 NVPQGVAWNGNNIGGSlKRAVGIAMHVGFGNLGGAVS 417
Cdd:pfam07690 308 VFPALNALVSDLAPKE-ERGTASGLYNTAGSLGGALG 343
 
Name Accession Description Interval E-value
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 63-448 1.20e-117

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 351.55  E-value: 1.20e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  63 DRANIGNAKLAGLEADLNMEGYDYSIAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLA 142
Cdd:cd17327   20 DKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIA 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 143 VRSLLGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEMKGVGGLSGWNWIFILEGLATFVV 222
Cdd:cd17327  100 LRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVGGLAGWRWLFIIEGLITIII 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 223 ALIAYRVMHDYPETVKFLNPEQKKEVVRRLKQDRSALSN-EFKLSLAKDALKDWKIWVHMLITIGIYIPLYSISVFLPTI 301
Cdd:cd17327  180 GLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDqKFKWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLI 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 302 VKGLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQRGIYMIGFNLIAILGFALLAAVQSHGVKYFACFLVTVGVYPN 381
Cdd:cd17327  260 LKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLAAPNPPGAYFAAYILGGGSYAG 339

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 346324509 382 VPQGVAWNGNNIGGSLKRAVGIAMHVGFGNLGGAVSGFVFRQVEAPRYLSGHLALVGTLSMSLVLTI 448
Cdd:cd17327  340 FPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIFRAGDAPRYIPGNIALLVCACVSIVLSV 406
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 63-424 4.10e-46

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 165.20  E-value: 4.10e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509   63 DRANIGNAKLAgLEADLNMEGYDYSIAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLA 142
Cdd:TIGR00893   9 DRANLSFAAPM-LQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLYI 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  143 VRSLLGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEMkgvgglSGWNWIFILEGLATFVV 222
Cdd:TIGR00893  88 LRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIH------FSWQWAFIIEGVLGIIW 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  223 ALIAYRVMHDYPETVKFLNPEQKKEVVRRLKQDRSALSN-EFKLSLAKDALKDWKIWVHMLITIGIYIPLYSISVFLPT- 300
Cdd:TIGR00893 162 GVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPsTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPTy 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  301 IVKGLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQRGIYMIGFNLIAILGFALLA----AVQSHGVKYFACFLVTV 376
Cdd:TIGR00893 242 LVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSllmfATNYVNIPYAALALVAL 321

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 346324509  377 GVYPNVPQGVAW-------NGNNIGGSlkravgiamhVGFGNLGGAVSGFVFRQV 424
Cdd:TIGR00893 322 GFFGLGAGAIGWalisdnaPGNIAGLT----------GGLINSLGNLGGIVGPIV 366
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 63-450 1.14e-37

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 141.55  E-value: 1.14e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  63 DRANIGNAKLAgLEADLNMEGYDYSIAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLA 142
Cdd:cd17319   18 DRVNISVAAPT-IMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 143 VRSLLGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEMKgvgglsGWNWIFILEGLATFVV 222
Cdd:cd17319   97 LRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF------GWRWAFIIEGLLGLLL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 223 ALIAYRVMhdypetvkflnpeqkkevvrrlkqdrsalsnefklslakdalkdWKIWVHMLITIGIYIPLYSISVFLPTIV 302
Cdd:cd17319  171 AVLWWFYL--------------------------------------------RQVWGLALGYFGINYALYGLLTWLPTYL 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 303 K-GLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRH--GQRGIYMIGFNLIAILGFALLAAVQSHGVKYFACFLVTVGVY 379
Cdd:cd17319  207 KqARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIG 286

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 346324509 380 pnVPQGVAW-NGNNIGGSLKRAVGIAMHVGFGNLGGAVS----GFVFRQVEAprYLSGHLALVGTLSMSLVLTIFM 450
Cdd:cd17319  287 --AASPVFWsLPADLLPGEAAATAGGLINSGGNLGGFVAplliGYLVDATGS--YTAAFLFLAAVALLAALLVLLL 358
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
63-460 1.79e-35

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 135.38  E-value: 1.79e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  63 DRANIGNAKLAgLEADLNMEGYDYSIAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLA 142
Cdd:COG2271   25 DRSNLSVAAPP-LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 143 VRSLLGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEmkgvggLSGWNWIFILEGLATFVV 222
Cdd:COG2271  104 LRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA------AFGWRAAFLILGLPGLLL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 223 ALIAyrvmhdypetvkflnpeqkkevvrrlkqdrsalsnefklslakdalkdwkIWVHMLITIGIYIPLYSISVFLPTI- 301
Cdd:COG2271  178 ALLR--------------------------------------------------FWLLALAYFLVYFALYGFLTWLPTYl 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 302 VKGLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQRG-IYMIGFNLIAILGFALLAAVQSHGVKYFACFLVTVGVYP 380
Cdd:COG2271  208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGG 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 381 NVPQGVAWNGNNIGGSLkRAVGIAMHVGFGNLGGAVSGFVFRQVEApryLSGHLALVGTLSMSLVLTIFMTIYLRRENAR 460
Cdd:COG2271  288 AFGLLWALAAELFPKKA-RGTASGLVNTFGFLGGALGPLLVGYLLD---ATGYQAAFLLLAALALLAALLALLLLRETRK 363
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
75-463 3.19e-26

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 109.97  E-value: 3.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  75 LEADLNMEGYDYSIAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLAVRSLLGLAEGGL 154
Cdd:COG2223   31 LAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGS 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 155 FPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEMkgvgglSGWNWIFILEGLATFVVALIAYRVMHDYP 234
Cdd:COG2223  111 FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAA------FGWRNAFLILGILLLVVAVLAWLFLRDPP 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 235 ETVKFLNPEQKKEvvrrlkqdrsalsnefklslAKDALKDWKIWVHMLITIGIYIPLYSISVFLPTIVKG-LGYTSEVAQ 313
Cdd:COG2223  185 AGAAAAAKASLRD--------------------QLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAATAG 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 314 LMSVPPYAVACLFTVGGGFLADRHGQRGIYMIGFnLIAILGFALLAAVQSHGVKYFACFLV----TVGVYPNVPQGVA-- 387
Cdd:COG2223  245 LLAALFALLGALGRPLGGWLSDRIGGRRVLLIVF-ALMALGLLLLALALGSLWLFLVLFLLlglaLGGGNGAVFALVPdi 323

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 346324509 388 WNGNNIGGslkrAVGIAmhVGFGNLGGAVSGFVFRQVEApRYLSGHLALVGTLSMSLVLTIFMTIYLRRENARRDA 463
Cdd:COG2223  324 FPTKNAGA----VYGLV--GAAGGLGGFLGPLLFGALLD-ATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
MFS_1 pfam07690
Major Facilitator Superfamily;
63-417 4.31e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 94.41  E-value: 4.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509   63 DRANIGNAKLAGLEADLNMEGYDYSIAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLA 142
Cdd:pfam07690  11 GRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  143 VRSLLGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEmkgvggLSGWNWIFILEGLATFVV 222
Cdd:pfam07690  91 LRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS------LFGWRAAFLILAILSLLA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  223 ALIAYrvmhdypetvkFLNPEQKKEVVRRLKQDRsalsnEFKLSLAKDALKDWKIWVhMLITIGIYIPLYSISVFLPTIV 302
Cdd:pfam07690 165 AVLLL-----------LPRPPPESKRPKPAEEAR-----LSLIVAWKALLRDPVLWL-LLALLLFGFAFFGLLTYLPLYQ 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  303 KGLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQRGIYMIGFNLIAI--LGFALLAAVQSHGVKYFACFLVTVGVYP 380
Cdd:pfam07690 228 EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILaaLGLLLLSLTLSSLWLLLALLLLGFGFGL 307

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 346324509  381 NVPQGVAWNGNNIGGSlKRAVGIAMHVGFGNLGGAVS 417
Cdd:pfam07690 308 VFPALNALVSDLAPKE-ERGTASGLYNTAGSLGGALG 343
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 86-421 5.02e-19

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 88.64  E-value: 5.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  86 YSIAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLAVRSLLGLAEGGLFPGITYYITMW 165
Cdd:cd06174   33 LGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 166 YRRHECGLRMAIFFSAATAAGAFGGLLARGIMEMKGVgglsGWNWIFILEGLATFVVALIAYRVMHDYPetvkflnpeqk 245
Cdd:cd06174  113 FPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF----GWRAVFLIAAALALLAAILLLLVVPDPP----------- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 246 kevvRRLKQDRSALSNEFKLSLAKDALKDWKIWVHMLITIGIYIPLYSISVFLPT-IVKGLGYTSEVAQLMSVPPYAVAC 324
Cdd:cd06174  178 ----ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLfLLDLGGLSVAVAGLLLSLFGLAGA 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 325 LFTVGGGFLADRH-GQRGIYMIGFNLIAILGFALLAAVQSHGVKYFACFLVTVGVYPNVPQGVAWNGNNIGGSLKRAVGI 403
Cdd:cd06174  254 LGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGL 333

                        330
                 ....*....|....*...
gi 346324509 404 AMHvgFGNLGGAVSGFVF 421
Cdd:cd06174  334 LNT--FGFLGGAIGPLLA 349
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
72-417 9.39e-19

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 87.34  E-value: 9.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  72 LAGLEADLNMEGYDYSIAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLAVRSLLGLAE 151
Cdd:COG2814   33 LPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 152 GGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEmkgvggLSGWNWIFILEGLATFVVALIAYRVMh 231
Cdd:COG2814  113 GALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD------LFGWRWVFLVNAVLALLALLLLLRLL- 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 232 dypetvkflnPEQKKEVVRRLKQDrsalsnefklslAKDALKDWKIWVHMLITIGIYIPLYSISVFLPTIVK-GLGYTSE 310
Cdd:COG2814  186 ----------PESRPAARARLRGS------------LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQeVLGLSAS 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 311 VAQLMSVPPYAVACLFTVGGGFLADRHGQRGIYMIGFnLIAILGFALLAAVQSHGVKYFACFLVTVGVYPNVPQGVAWNG 390
Cdd:COG2814  244 AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGL-LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322

                        330       340
                 ....*....|....*....|....*..
gi 346324509 391 NNIGGSLkRAVGIAMHVGFGNLGGAVS 417
Cdd:COG2814  323 ELAPPEA-RGRASGLYNSAFFLGGPLA 348
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 77-451 9.45e-15

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 75.75  E-value: 9.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  77 ADLNMEGYDYSIAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGV-VKSFGGLLAVRSLLGLAeGGLF 155
Cdd:cd17341   27 DDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALaVSSYWGLLVLGFLLGFA-GANF 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 156 PGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIME-MKGVGGLSGWNWIFILEGLATFVVALIAYRVMHDYP 234
Cdd:cd17341  106 ASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGaIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLP 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 235 ETVKflnpeqkkevvrrlkqdrsalSNEFKLSLAKDALKDWKIWVHML---ITIGIYIplySISVFLPT-IVKGLGYTSE 310
Cdd:cd17341  186 TGKA---------------------SALEFLKVQLAVLKNYRTWILSLlygVTFGSFV---GFSNVLPTyFKTRFGLPLV 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 311 VAQLMSVPPYAVACLFTVGGGFLADRHGQRGIYMIGFNLIAILGFALLAAVQSHGVKYFACFLVTVGVYPNVPQGVAWNG 390
Cdd:cd17341  242 TAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVF 321

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 346324509 391 NNIGGSLKRAVGIA--MHVGFGNLGGAVSGFVFRQVEAPRYlSGHLALVGTLSMSLVLTIFMT 451
Cdd:cd17341  322 RMVPFIFRRELGAVtgLVGAIGGLGGFFLPLLFGSSALMTG-SGVGAFSLFGVLAVACTLLVW 383
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 85-421 1.14e-12

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 69.33  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509   85 DYSIAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLAVRSLLGLAEGGLFPGITYYITM 164
Cdd:TIGR00881  31 DLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  165 WYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEMkgvggLSGWNWIFILEGLATFVVALIAYRVMHDYPETVKFLNPEQ 244
Cdd:TIGR00881 111 WFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAE-----LYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEE 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  245 KK--EVVRRLKQDRSALSNefKLSLAKDALKDWKIWVHMLITIGIYIPLYSISVFLPT-IVKGLGYTSEVA-QLMSVPPY 320
Cdd:TIGR00881 186 MPneEPDGDAEKKEEELTK--KQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLyLTQEKGFSKEKAsWAFTLYEL 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  321 AvACLFTVGGGFLADR--HGQRG----IYMIGFnLIAILGFALLAAvqSHGVKYFACFLVtVGVYPNVPQGVAWNGNNiG 394
Cdd:TIGR00881 264 G-GLVGTLLAGWLSDKlfNGRRGplavFFMALI-IVSLLVYWLNPA--ANPLMDLICLFA-LGFLVYGPQMLIGVIAS-E 337

                         330       340
                  ....*....|....*....|....*....
gi 346324509  395 GSLKRAVGIAMHVG--FGNLGGAVSGFVF 421
Cdd:TIGR00881 338 LAPKKAAGTAAGFVgfFAYLGGILAGLPL 366
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 77-378 1.41e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 62.98  E-value: 1.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  77 ADLNMEGYDYSIAVAIFFPFYVIAEIPSNMAMKRF--RPSIWIPsiMVVWGFMTIMLGVVKSFGGLLAVRSLLGLAEGGL 154
Cdd:cd17325   24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFgrKRLLLLG--LLLLAVSTLLFAFATSYWQLLLARFLQGLASAAV 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 155 FPGITYYITMWYRRHECGLRMAIFFSAATAagafggllarGIMEMKGVGGL----SGWNWIFILEGLATFVVALIAYRVM 230
Cdd:cd17325  102 WPAAMALIADIAPPEERGRAMGIFSSAIGL----------GFLIGPLLGGLladaLGYRAPFLVCAALALLALVLALLLL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 231 HDypetvkflnpeqkkevvRRLKQDRSALSNEFKLSLAKDALKDWKIWVHMLITIGIYIPLYSISVFLPTIVKGLGY--T 308
Cdd:cd17325  172 PE-----------------PRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlsP 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 309 SEVAQLMSVpPYAVACLFTVGGGFLADRHGQRGIYMIGFnLIAILGFALLAAVQSHGVKYFACFLVTVGV 378
Cdd:cd17325  235 AQIGLLFGA-QGLASALSQPPAGKLSDRIGRKPLILIGL-LLSAVALLLLPLATSFWLLLLLLALLGLGL 302
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 86-446 2.47e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 59.10  E-value: 2.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  86 YSIAVAIFFPFYVIAeiPSNMAMKRFrpsiwIPSIMVVWGFMTIMLGVVKSFGGLLAVRSLLGLAEGGLFPGITYYITMW 165
Cdd:cd17324   43 YALGYALGALLLGPL--SDRIERRRL-----LLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 166 YRRHECGLRMAIFFSAATAAGAFGGLLARGImemkgvGGLSGWNWIFILEGLATFVVALIAYRVMhdypetvkflnPEQK 245
Cdd:cd17324  116 VPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL------GQLLGWRAAFLAIAVLALLAALLLWRLL-----------PSLP 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 246 KEVVRRLKqdrsALSNEFKLslakdaLKDWKIWVHMLITIGIYIPLYSISVFLPTIVKGLGYTSEVAQLMSVPPYAVACL 325
Cdd:cd17324  179 PKKPGSLG----LLSSLLLL------LRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGV 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 326 F-TVGGGFLADRHGQRGIYMIGFnLIAILGFALLAAVQSHGVKYFACFLVTVGVYPNVPQGVAWNGNNIGGSlkRAVGIA 404
Cdd:cd17324  249 VgSPLAGRLADRGGRRALLIALL-LLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA--RGLASS 325

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 346324509 405 MHVGFGNLGGAVSGFVFRQVeaprYLSGHLALVGTLSMSLVL 446
Cdd:cd17324  326 LYLAAYNLGGALGAALGGLV----LDHGGWAGVGWVGAALLL 363
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 121-452 5.22e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 58.00  E-value: 5.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 121 MVVWGFMTIMLGVVKSFGGLLAVRSLLGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEMk 200
Cdd:cd17316   73 LLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPL- 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 201 gVGGLSGWNWIFILEGLATFVVALIAYRvmhdypetvkflnpeqkkevvrrlkqdrsalsnefklslakdalkdwkIWVH 280
Cdd:cd17316  152 -LSGDWGWRILFLIGALPALLALLLRRR------------------------------------------------TLLL 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 281 MLITIGIYIPLYSISVFLPTI-VKGLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQRGIYMIGFNLIAILGFALLA 359
Cdd:cd17316  183 ILLWFFISFGYYGLTTFLPTYlQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFY 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 360 AVQSHGVKYFACFLVTVGVYpNVPQGVAWN-GNNIGGSLKRAVGIAMHVGFGNLGGAVSGFVFrqveaPRYLSGHLALVG 438
Cdd:cd17316  263 LLSGSPTLLLLLLFILSFFV-GGVWGALYAyLAELFPTEVRATGVGLSYNLGRLGGGGAPPLI-----ALLLASTGGTGV 336

                        330
                 ....*....|....
gi 346324509 439 TLSMSLVLTIFMTI 452
Cdd:cd17316  337 PALILALLAIVALI 350
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
275-421 1.00e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 57.19  E-value: 1.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 275 WKIWVH-MLITIGIYIPLYSISVFLPTIVKGLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQRGIYMIGFnLIAIL 353
Cdd:COG2271    9 WRILALlFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL-LLWGL 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 346324509 354 GFALLAAVQSHGVKYFACFLVTVGVYPNVPQGVAWNGNNIGGSlKRAVGIAMHVGFGNLGGAVSGFVF 421
Cdd:COG2271   88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPK-ERGRALGIFNAGGPLGGALAPPLL 154
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 86-454 1.26e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 56.81  E-value: 1.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  86 YSIAVAIFFPFyviaeipSNMAMKRF-RPSIWIPSiMVVWGFMTIMLGVVKSFGGLLAVRSLLGLAEGGLFPGITYYITM 164
Cdd:cd17473   44 PALFIALFAPL-------AGWLADRFgRKRLLIAG-LLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGD 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 165 WYRRHECGLRMAIFFSAATAAGAFGGLLArgimemkGVGGLSGWNWIFILEGLAtFVVALIAYRVMHDypetvkflnPEQ 244
Cdd:cd17473  116 YFEGEERAKMLGLQSAAMSLGGVVFLLLG-------GALAEIGWRAPFLVYLLA-LPVLILVLLFLPE---------PAR 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 245 KKEVVRRlkqdrsalsnefKLSLAKDALKDWKIWVHMLITIGIYIPLYSISVFLPTIVKGLGYTSE--VAQLMSVPPYAV 322
Cdd:cd17473  179 KSKSAAS------------PGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAalIGLALAIASLAG 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 323 AclftVGG---GFLADRHGQRGIYMIGFNLIAIlGFALLAAVQSHGVKYFACFLVTVGVYPNVPQGVAWNGNNIGGSLkR 399
Cdd:cd17473  247 A----IGAllfGRLKRRLGKRRLLAIGFALMAL-GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPEL-R 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 346324509 400 AVGIAMHVGFGNLGGAVSGFVFRQVEApRYLSGHLALVGTLSMSLVLTIFMTIYL 454
Cdd:cd17473  321 GRAMGIVTSAFFLGQFLSPLVLGPLVN-LTGGLSGAFLILGVLALVLAIVLLLLR 374
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
87-464 1.03e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.01  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  87 SIAVAIFFPFYVIAEIPSNMAMKRF--RPSIWIPSIMVVWGFmtIMLGVVKSFGGLLAVRSLLGLAEGGLFPGITYYITM 164
Cdd:COG0738   46 GLLLFAFFLGYLLASLPAGRLIDRFgyKRGLLLGLLLMALGL--LLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 165 WYRRHEcGLRMAIFFSAATAAGAFGGLLARGIMemkGVGGLSGWNWIFILEGLATFVVALIAYRvmhdypetVKFlnPEQ 244
Cdd:COG0738  124 LGPETA-ASRLNLLHAFFSLGALLGPLLGGLLI---LLGLSLSWHLPYLILAVLLLLLALLFLR--------SKL--PEI 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 245 KKEVVRRLKQDRSALSnefklslakdALKDWKIWVHMLITIGIYIPLYSISVFLPTIVK-GLGYTSEVAQLMSVppyAVA 323
Cdd:COG0738  190 EEEEEEAAGSAASLKS----------LLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKdVLGLSEATAALGLS---LFW 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 324 CLFTVG---GGFLADRHGQRGIYMIGFnLIAILGFALLAAVQSHGVKYFACFLVTVGVYPNVPQGVAWNGNNIGGSLKRA 400
Cdd:COG0738  257 GGMTIGrflGGFLLKRFGPVRLLRLSA-LLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAA 335

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 346324509 401 VGIAMhvGFGNLGGAVSGFVFrqveapRYLSGHLALVGTLSMSLVLTIFMTIYLRRENARRDAQ 464
Cdd:COG0738  336 VSAVL--IMGIVGGAIGPPLI------GFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 64-421 1.16e-06

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 50.74  E-value: 1.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  64 RANIGNAKLaGLEADLNMEGYDYSIAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLAV 143
Cdd:cd17312   19 RKNFSVAKP-PIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 144 RSLLGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMemkgvgGLSGWNWIFILEGLATFVVA 223
Cdd:cd17312   98 WGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLA------SYYGWRAAFLVPGIVGLVVA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 224 LIAYRVMHDYPetvkflnpeqkkevvrrlkqdrsalsnefklslakdalkdWKIWVHMLITIGIYIPLYSISVFLPTIVK 303
Cdd:cd17312  172 IILFFFLRDSP----------------------------------------PYVWVLSLAYAFVYIVRYACLDWGPLYLY 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 304 GLGYTSEVAQLMSVPPYAVACLF-TVGGGFLADR--HGQRGIYMIGFNLIAILGFALLAAVqSHGVKYFACFLVTVGVYP 380
Cdd:cd17312  212 EVKGYSLIDAGWFSSLYEVGGIAgTILAGLLSDKlfGGRRAPIAVIYMLLMTLSLALFWFF-PHNKLLSIVLLFLIGFFV 290

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 346324509 381 NVPQGVAWNGNNIGGSLKRAVGIAMHV--GFGNLGGAVSGFVF 421
Cdd:cd17312  291 GGPINLIGGAAAQDIGRKEAAGTATGFvgLFGYLGASLAGLPL 333
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 217-377 1.38e-06

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 50.60  E-value: 1.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 217 LATFVVALIAYRVMHDYPETVKFLNPEQKKEVVRRlkqdrsalsnefklSLAKDALKDWK-IWVHMLITIGIYIPLYSIS 295
Cdd:cd17369  183 LLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVVRA--------------PLVEVLRRHWRaLLLAIGLRLAENVLFYLFT 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 296 VFLPT-IVKGLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQRGIYMIGFNLIAILGFALLAAVQSHGVKYFACFLV 374
Cdd:cd17369  249 TFALSyATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAV 328


                 ...
gi 346324509 375 TVG 377
Cdd:cd17369  329 VVL 331
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
191-464 3.95e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 49.13  E-value: 3.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 191 LLARGIMEMKGVGGLSGWNWIFILEGLATFVVALIAYRVMHDYPEtvkflnPEQKKEVVRRLkqdrsalsnefklslAKD 270
Cdd:COG2211  165 VLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPV------PEEEKVSLKES---------------LKA 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 271 ALKDWKIWVHMLITIGIYIPLYSISVFLPTIVK-GLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQRGIYMIGFnL 349
Cdd:COG2211  224 LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKyVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL-L 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 350 IAILGFALLAAVQSHGVKYFACFLVTVGVYPNVPQGVAWN--------GNNIGGSLKRAVGIAMHVGFGNLGGAVS---- 417
Cdd:COG2211  303 LAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAmladvvdyDEWKTGRRREGLYFGIFTFAIKLGQALAgala 382

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 346324509 418 -------GFVFRQVEAPRYLSGHLALVGTLSMSLVLTIFMTIYLRRENARRDAQ 464
Cdd:COG2211  383 glllalfGYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAE 436
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 97-390 8.46e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 48.00  E-value: 8.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  97 YVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLAVRSLLGLAEGGLFPGITYYITMWYRRHECGLRMA 176
Cdd:cd17475   44 VAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMG 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 177 IFFSAATAAGAFGGLLargimeMKGVGGLSGWNWIFILEGLATFVVALIAYRVMHDYPEtvkflnpeqkkevvrrlkQDR 256
Cdd:cd17475  124 IRQTGVPLGGALAAAL------LPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPA------------------ASA 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 257 SALSNEFKLSLAKDALKDWKIWVHMLITIGIYIPLYSISVFLPTIVK-GLGYT-SEVAQLMSVPPYAVAcLFTVGGGFLA 334
Cdd:cd17475  180 ATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHdHLGLSvVAAGALLAVAQLGGA-LGRIGLGRVS 258

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 335 DRH--GQRGIYMIGFNLIAILGFALLAAVqSHGVKYFACFLVTV--GVYpnvpqGVAWNG 390
Cdd:cd17475  259 DRVfgGRRRPVLVITAAIAAAALLVLSLL-SPGTPLWLLVLLLIllGLF-----AIGWNG 312
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 119-421 1.70e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 46.91  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 119 SIMVVW-GFMTIMLGVVKSFGGLLAVRSLLGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIM 197
Cdd:cd17371   68 VITILLfAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLF 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 198 EMkgVGGLSGWNWIFILEGLATFVVALIAYRVmhdyPETVKFlnpeQKKEVVRRLKQDRSALSNEFKLSLAKDALkdwkI 277
Cdd:cd17371  148 PL--LPPEIAWRVLFLLGALPALLVLFIRRFV----KEPPQW----QAARAARRHFADRPSLRELFSPPLLRTTL----L 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 278 WVhmLITIGIYIPLYSISVFLPTIVKG-LGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQRGIYMIGFNLIAIlgfA 356
Cdd:cd17371  214 AS--LLATGALGGYYGITTWLPSYLTGeRGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAI---S 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 357 LLAAVQSHG------VKYFACFLVTVGVY------------PNV---PQGVAWNGNNIGGSLKRAV--GIAMHVGFGNLG 413
Cdd:cd17371  289 ILLYFFLPLsptlilILGFPLGFFASGPFsgmgayltelfpTAVratAQGFCYNVGRIIGALFPFLvgFLATSGSLGTAI 368


                 ....*...
gi 346324509 414 GAVSGFVF 421
Cdd:cd17371  369 AVFAAVYY 376
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 207-417 3.28e-05

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 46.20  E-value: 3.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  207 GWNWIFILEGLATFVVALIAYRVMhdyPETVKFL---NPEQKKEVVRRL-----KQDRSAL----SNEFKLSLAKDALKD 274
Cdd:TIGR00895 169 GWRSLFYVGGIAPLLLLLLLMRFL---PESIDFLvskRPETVRRIVNAIapqmqAEAQSALpeqkSTQGTKRSVFKALFQ 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  275 WK-------IWVHMLITIGIYiplYSISVFLPTIVKGLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGqRGIYMIGF 347
Cdd:TIGR00895 246 GKtaritvlLWLLYFMLLVGV---YFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLG-PRVTALLL 321

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 346324509  348 NLIAIlgFALLAAVQSHGVKYFACFLVTVGVYPNVPQGVAWN------GNNIggslkRAVGIAMHVGFGNLGGAVS 417
Cdd:TIGR00895 322 LLGAV--FAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYAlmalfyPTAI-----RATGVGWAIGIGRLGAIIG 390
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 204-420 4.95e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 45.62  E-value: 4.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 204 GLSGWNWIFILEGLAtfvVALIAYRVMHDYPETVKFLNPEQKKEVVRRlkqdrsalsnefklslakdalKDWKIWVHMLI 283
Cdd:cd17478  147 GGLGLLILLIIPGLA---VALLLLRLRPLKKPEAKKAAAKSSARSTLK---------------------GVWRALLLLLI 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 284 TIGI-YIPLYSISVFLPTIVKGLGYTSEVAQLM-SVppYAVACLF-TVGGGFLADRHGQRGIYMIGFnLIAILGFALLAA 360
Cdd:cd17478  203 IVFLrSWVLSSLTTFLPFYLVQRGYSLVFAGLLlSL--FLFAGAIgTLIGGPLSDRFGRRRVIIASL-LLAAPFLLLFLL 279

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 346324509 361 VQSHGVkYFACFLVTVGVYPNVPQGVAWNGNNIGGSLKRAVGIAMHVGF--GNLGGAVSGFV 420
Cdd:cd17478  280 TPGIWS-YILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMGLSFglGGIGAPVLGAL 340
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 93-420 5.59e-05

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 45.30  E-value: 5.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  93 FFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIM--LGVVKSFGGLLAVRSLLGLAEGGLFPGITYYITMWYRRHE 170
Cdd:cd17318   65 FFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLtpLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLE 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 171 CGLRMAIFFSAATAAGAFGGLLARGIMEmkgvggLSGWNWIFILEGLATFVVALIAyrvmhdypetvkflnpeqkkevvr 250
Cdd:cd17318  145 RSRLTSIAYSGSQFGTVIAMPLSGFLCE------SLGWPSIFYIFGGLGLLWCLLW------------------------ 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 251 rlkqdrsalsneFKLSLAkdalkdwkIWVHMLITIGIYIPLYSISVFLPTIVKG-LGYTSEVAQLMSVPPYAVACLFTVG 329
Cdd:cd17318  195 ------------FFLVLP--------VWAIVVAHFGHNWGFYTLLTELPTYMSDvLHFNIKSNGFLSSLPYLAMWICSIV 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 330 GGFLADRHGQRGIYMIG-----FNLIAILGFALLAAVQSHGV--KYFACFLVTVGVypnVPQGVAWNGNNIGG-SLK-RA 400
Cdd:cd17318  255 GGYLADWLRSRGILSTTtvrklFTSIGFLGPGVFLIALGYLGsnATLAVVFLTLSV---GLSGACYSGFLVNHlDLApNY 331

                        330       340
                 ....*....|....*....|
gi 346324509 401 VGIAMhvGFGNLGGAVSGFV 420
Cdd:cd17318  332 AGTLM--GITNTAATIAGII 349
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
 98-414 8.53e-05

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 44.60  E-value: 8.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509   98 VIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLG-VVKSFGGLLAVRSLLGLAeGGLFPGITYYITMWYRRHECGLRMA 176
Cdd:TIGR00886  51 AVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGlAVQSYSVLLLIRLFIGIA-GGSFASCMPWISFFFPKKIQGTALG 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  177 IFFSA----ATAAGAFGGLLARGIMEMKGVGGLSGWNW-IFILEGLATFVVALIAYRVMHDYPetvkflnPEQKKEVVrr 251
Cdd:TIGR00886 130 LAAGWgnmgGGVAQFVMPPIIGSLIFGGGQPAHLAWGWaFVIVPAGILLLPALLIFFVGADTP-------PGKPATGK-- 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  252 lkqdrsalsneFKLSLAKDALKDWKIWVHML---ITIGIYIPLYSISVFLPTIVKGLGyTSEVAQLMSVPPYAVAcLFTV 328
Cdd:TIGR00886 201 -----------LSFKEALKVFGNRHTWILALlysVTFGSFLGVSSIFAMLFKDQFGLS-KVQAGAYASLGGFLGS-LARP 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  329 GGGFLADRHGQRGIYMIGFnLIAILGFALLAAVQSHGVKYFACFLVTVGVYPNVPQGvawNGNNIG---GSLKRAVGIAM 405
Cdd:TIGR00886 268 AGGAISDRLGGARKLLMNF-LGVAMGAFLVVLGLVSDGSLAAFIVLFVALFFFAGAG---NGSTFAlvpHIFRRATGAVS 343

                         330
                  ....*....|.
gi 346324509  406 HV--GFGNLGG 414
Cdd:TIGR00886 344 GLigAIGNLGG 354
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 93-454 1.14e-04

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 44.47  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  93 FFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVK--SFGGLLAVRSLLGLAEGGLFPGITYYITMWYRRHE 170
Cdd:cd17380   43 FFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAysSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSE 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 171 CGLRMAIFFSAATAAGAFGGLLARGIMEMkgvgglSGWNWIFILEGLATFVVALIAYRVmhdYPETvkflnpeqkkevvr 250
Cdd:cd17380  123 RSRAVSIVTAGSYLGTLLGGLIGPLLLEY------YGWPSVFYFFGLLGLLWALVWLIY---LPPV-------------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 251 rlkqdrsalsnefklslakdalkdWKIWV-HMLITIGIYI-----PLYSISVFLPtIVKGLGYTsevaqlmsVPPYAVAC 324
Cdd:cd17380  180 ------------------------WAIIVaHFCMNWGFYIllswlPTYFHEVLVP-LAKGWVFN--------VVPWLVMF 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 325 LFTVGGGFLADRHGQRG---------IYMIGFnLIAILGFALLAAVQShgvKYFACFLVTV----------GVYPNvPQG 385
Cdd:cd17380  227 PSSNVAGWLADHLISRGwtvtsvrklMQSIGF-LGPALFLLLLSHTDS---FSLALLCMSValglsafsssGVLVN-HQD 301

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 346324509 386 VAwngnniggslKRAVGIAMhvGFGNLGGAVSGFVfrqveaPRYLSGHLaLVGTLSMSLVLTIFMTIYL 454
Cdd:cd17380  302 IA----------PNYAGIVF--GISNTAGTIPGIV------GVYLTGYI-LEATGSWSLVFVLAAVVNL 351
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 140-360 8.03e-04

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 42.04  E-value: 8.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  140 LLAVRSLLGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEMKGvgglsGWNWIFILEGLAT 219
Cdd:TIGR00894 134 VVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWG-----GWPMIFYVFGIVG 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  220 FVVALIAYRVMHDYPETVKFLNPEQKKEVVRRLKQDRSalSNEFKLsLAKDALKDWKIWVHMLITIGIYIPLYSISVFLP 299
Cdd:TIGR00894 209 CAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQKG--STRQSL-PIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLP 285

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 346324509  300 TIVKG-LGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQRGIYMIG-----FNLIAILGFALLAA 360
Cdd:TIGR00894 286 TFISWvLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTLSLTaarkiFNGIGGLGPGIFAY 352
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 292-452 9.03e-04

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 41.47  E-value: 9.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 292 YSISVFLPTIVKGLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQRGIYMIGFNLIAILGFALLAAVQSHGVKYFAC 371
Cdd:cd17341   16 FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 372 FLVTVGVyPNVPQGVAWNGNNIGGSLKR-AVGIAmhVGFGNLGGAVSGFVF-RQVEAPRYLSGHLALVGTLSMSLVLTIF 449
Cdd:cd17341   96 FLLGFAG-ANFASGQPWASFWFPKEKIGgAAGGI--AGAGNMGVAVSQLLApLIAGAIVFDGGFVGWRNAFFVPGILLAI 172


                 ...
gi 346324509 450 MTI 452
Cdd:cd17341  173 AAV 175
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 110-449 1.34e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.06  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 110 RFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLAVRSLLGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFG 189
Cdd:cd17329   61 RFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIG 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 190 GLLArgimemkGVGGLSGWNWIFILEGLATFVVALIAYRVmhdYPETVKFLNPEQKKEVVRRLKQdrsalsnefklslak 269
Cdd:cd17329  141 PLLG-------GLLLLYSFRLLFLAAAVLFLLAALVLLFL---LPETRPKRRAAEKTEILRGYKI--------------- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 270 dALKDWKIWVHMLITIGIYIPLYSISVFLPTIVK--GLGYTSEVAQLmsvppYAVACLFTVGGGF----LADRHGQRGIY 343
Cdd:cd17329  196 -VLRDRAFLLFLLASFLISLIYFQLESTLPVYVVeiLGLGESLLGLL-----LALNALLIVLLQFpvarLVERFRLRKIL 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 344 MIGFnLIAILGFALLAAVQSHGVKYFACFLVTVG---VYPNVPQGVAwngnNIGGSLKRAV---GIAMHVGFGNLGGAVS 417
Cdd:cd17329  270 MIGI-LLFAIGFAVLAFANTLAVLILAMIVLTLGemlVFPAVQTLVA----ALAPPDKRGSymgFYALAWGLGRAIGPLV 344

                        330       340       350
                 ....*....|....*....|....*....|..
gi 346324509 418 GFVFRQVEAPRYLSGHLALVGTLSMSLVLTIF 449
Cdd:cd17329  345 GGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 204-363 2.26e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 40.22  E-value: 2.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 204 GLSGWNWIFILEGLATFVVALIayrvmhdypetvkflnpeqkkeVVRRLKQDRSALSNEFKLSLAKDALKDWKIWVHMLI 283
Cdd:cd17471  150 DVLGFTGLFLLAALLYLVVALL----------------------VLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAA 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 284 TI---------GIYIPLYsisvflptIVKGLGYTSE-VAQLMSVPPyAVACLFTVGGGFLADRHGQRGIYMIGFnLIAIL 353
Cdd:cd17471  208 FTllfaansmyIIAMPLY--------VTNELGGSESwVGLLFGLAA-ALEIPIMLLAGLLAKRFGKRRLLLAGF-LAGVL 277

                        170
                 ....*....|
gi 346324509 354 GFALLAAVQS 363
Cdd:cd17471  278 FYLGLALATS 287
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
121-456 2.63e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 40.24  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 121 MVVWGFMTIMLGVVKSFGGLLAVRSLLGLAEGGLFPGITYYITMWYRRHEcGLRMAIFFSAATAAGAFGGLLARGIMEmk 200
Cdd:COG2807   90 LLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRV-GLMTGLYTAAMGLGAALAAGLTVPLAA-- 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 201 gvggLSGWNWIFILEGLATFVVALIAYRVMHDYPETVkflNPEQKKEVVRRLKQDRSAlsnefklslakdalkdWKIWVH 280
Cdd:COG2807  167 ----ALGWRGALAVWALLALLALLLWLPLLRRRPAAA---AAAPAAASLRSLWRSPLA----------------WLLTLF 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 281 MLITIGIYiplYSISVFLPTIVKGLGYTSEVA-------QLMSVPpyavaclFTVGGGFLADRHGQRGIYMIGFNLIAIL 353
Cdd:COG2807  224 FGLQSLLY---YAVVAWLPPILRDAGLSAATAglllslfQLAGIP-------GSLLVPLLADRLGDRRPLLLLLGLLGLA 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 354 GFALLAAVQSHGVkYFACFLVTVGVYPNVPQGVAWNGNNIGGSLKRAVGIAMHVGFGNLGGAVSGFVFRQVeapRYLSG- 432
Cdd:COG2807  294 GLLGLLLAPGSLP-WLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGAL---HDATGs 369

                        330       340
                 ....*....|....*....|....*
gi 346324509 433 -HLALVGTLSMSLVLTIFMTIYLRR 456
Cdd:COG2807  370 wTAALLLLAALAVLMLVAGLLAGRP 394
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 88-363 3.87e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.50  E-value: 3.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  88 IAVAIFFPFYVIAEIPSNMAMKRFRPSIWIPSIMVVWGFMTIMLGVVKSFGGLLAVRSLLGLAEGGLFPGiTYYITMWY- 166
Cdd:cd17489   35 LVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA-AATLVADIi 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 167 ---RRHEC----GLRMAIffsaataagafggLLARGIMEMKGVGGLSGWNWIFILEGLATFVVALIAYRVmhdypetvKF 239
Cdd:cd17489  114 ppsRRGEGigyyGLATTL-------------AMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLV--------KD 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 240 LNPEQKKEvvrrlkqdrsalsnEFKLSLAKDALKDWKIWVHMLITIGIYIPLYSISVFLPTIVKGLGYtSEVAQLMSVpp 319
Cdd:cd17489  173 PPPVAAEE--------------AEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGI-SNAGLFFTV-- 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 346324509 320 YAVACLFT-VGGGFLADRHGQRGIYMIGFnLIAILGFALLAAVQS 363
Cdd:cd17489  236 YAIALLLSrPFSGKLSDRKGPKTVIIPGL-LLLALGLLLLSFAGS 279
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 126-455 4.03e-03

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 39.53  E-value: 4.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 126 FMTIMLGVVKSFGGLLAVRSLLGLAEGGLFP--GITyyITMWYRRHECGLRMAIFFSAATAAGAFGGLLARGIMEMKGVG 203
Cdd:cd17345   84 LIGFVPSATSSVGLMFILLFLNGWFQGMGWPpsGRT--MVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 204 GlsgWNWIFILEGLATFVVALIAYRVMHDYPETVKfLNP--EQKKEVVRRLKQDrsalSNEFKLS----LAKDALKDWKI 277
Cdd:cd17345  162 W---WRGAFIFPAIIAIIVAVIVLFLGKDTPESEG-LPPieEYKGDYPEEADGE----EEEQELSaweiFVKYVLKNKLL 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 278 WVHMLITIGIYIPLYSISVFLPTivkglgYTSEVAQlMSVPPYAVA-CLFTVGG-------GFLADR--HGQRGIYMIGF 347
Cdd:cd17345  234 WYIAIANVFVYLVRYGILDWAPT------YLSEVKG-FSKAQAMWAfSLFEWAAipgtllaGWLSDKlfKGRRAPTGIIF 306

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 348 nlIAILGFALLA--AVQSHGVKYFACFLVTVGVYpnVPQ---GVAwngnNIGGSLKRAVGIAmhVG----FGNLGGAVSG 418
Cdd:cd17345  307 --MILVIVALIVywLAPNVLVDLIALIALGFLIY--GPVmliGLQ----ALELVPKKAAGTA--AGltglFGYLGGSVLA 376

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 346324509 419 FVFRQVEAPRYlsGHLALVGTLSMSLVLTIFMTIYLR 455
Cdd:cd17345  377 TALIGIIVDHF--GWNGGFIVLLASCILAIIFLALVA 411
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 278-452 5.23e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 39.13  E-value: 5.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 278 WVHMLITIGIYiplYSISVFLPTIVKGLGYTSEVAQLMsvppYAVACLF----TVGGGFLADRHGQRGIYMIGFNLIAiL 353
Cdd:cd17353    9 AVLMHLILGYQ---YAWSVFNPPLSSALGWSLASVALA----FTLTIVFlaisAPFAGRLVDRGGPRKAILIGGILFG-L 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 354 GFALLA-AVQSHGVKYFACFLVTVG---VYP-NVPQGVAWNGNNIGGslkrAVGIAMhVGFGnLGGAVSGFVFrqveapR 428
Cdd:cd17353   81 GFILSAfAISLPLLFLGYGVLGGIGagiGYItPVSTAVKWFPDKRGL----ATGIVI-AGFG-LGSLIFSPLI------A 148

                        170       180
                 ....*....|....*....|....*
gi 346324509 429 YLSGHLALVGT-LSMSLVLTIFMTI 452
Cdd:cd17353  149 YLINTVGVPTTfLILGIIFLIIIVI 173
Sugar_tr pfam00083
Sugar (and other) transporter;
203-421 5.51e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 39.18  E-value: 5.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  203 GGLSGWNWIFILEglatFVVALIAYRVMHDYPETVKFL----NPEQKKEVVRRLK--QDRSALSNEFKLSLAKDALKDWK 276
Cdd:pfam00083 165 SNSDGWRIPLGLQ----LVPALLLIIGLLFLPESPRWLvekgRLEEAREVLAKLRgvPDVDRELDEIKDSLEAGQEAEKA 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  277 IWVHMLITIGIYIPLY---------------SISVFLPTIVKGLGYTSEVaqLMSVPPYAVACLFTVGGGFLADRHGQRG 341
Cdd:pfam00083 241 SWKELFSTKTRRQRLLigvmlqifqqltginAIFYYSTTIFENLGLSDSF--LVTIIVGVVNFVFTFIAIFLVDRFGRRP 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509  342 IYMIGFnLIAILGFALLAAVQSHGVK---------------YFACFLVTVG---------VYPNVP----QGVAWNGNNI 393
Cdd:pfam00083 319 LLLLGA-AGMAICFVILGIVALLGVSksdwagivaivfialFIAFFAMGWGpvpwvivseLFPLSVrskaMALATAANWL 397

                         250       260
                  ....*....|....*....|....*...
gi 346324509  394 GGSLkraVGIAMHVGFGNLGGAVSGFVF 421
Cdd:pfam00083 398 ANFL---IGFLFPIITDAIGLGYTFFIF 422
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 203-388 9.14e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 38.40  E-value: 9.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 203 GGLSGWNWIFILEGLatfvVALIAYRVMHDYPETVKFL-----NPEQKKEVVRRL---KQDRSALSNEFKLSLA------ 268
Cdd:cd17357  167 GTETLWPYLLFFPGI----PALLQLAALPFFPESPKFLliskgDEEEAEKSLKFLrgiEDDVDQELEEIKKESEqmgdqk 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 269 ----KDALKDWKIWVHMLITIGIYI-----PLYSISVFLPTIVKGLGYTSEVAQLMSVPPYAVACLFTVGGGFLADRHGQ 339
Cdd:cd17357  243 qvslMQLLRDPSLRLPLLLVLVVSAsqqfsGINAIFFYSTFIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGR 322

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 346324509 340 RGIYMIGFNLIA----ILGFALLAAVQSHGVKYF--ACFLVTVGVYPNVPQGVAW 388
Cdd:cd17357  323 RPLLLISLSVCAvallLMSVFLFLSEQNSWMSYGciVAIFLFIFFFAIGLGPIPW 377
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 121-376 9.86e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 38.37  E-value: 9.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 121 MVVWGFMTIMLGVVKSFGGLLAVRSLLGLAEGGLFPGITYYITMWYRRHECGLRMAIFFSAATAAGAFGGLLARgimEMK 200
Cdd:cd17328   71 ILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGG---LVA 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 201 GVGGlsGWNWIFILEGLATFVVALIAYRVMHDypetvkflnpeqkkevVRRLKQDRSALSNEFKLSLAKDALKDWKIWVH 280
Cdd:cd17328  148 QATG--GWRWAFRVTGVLGVLLAILLLLFVRE----------------PPRGAAEGGVMAKSTATSFLADLKALAKNPSF 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 346324509 281 MLITIG---IYIPLYSISVFLPT-IVKGLGYTSEVAQLMSVPPYAVACLF----TVGGGFLADRHGQRGIY------MIG 346
Cdd:cd17328  210 ILSTLGftaVSFVTGALAFWAPTfFLRAFGVGDLSSADVGLIFGAITCIAgvlgVLLGGILADRLRRKTPRadplvcAVG 289

                        250       260       270
                 ....*....|....*....|....*....|
gi 346324509 347 FNLIAILGFALLAAVQSHGVKYFACFLVTV 376
Cdd:cd17328  290 LLAAAPFLFLALVLALSNLLLAWVLLFLGE 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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