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Conserved domains on  [gi|340520488|gb|EGR50724|]
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predicted protein [Trichoderma reesei QM6a]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
83-385 2.30e-92

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 284.50  E-value: 2.30e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  83 KARLVLHGHTKAVSQVRISPNGRFIASASADATVKIWDAATGAHMDTLVGHMAGVSCVAWTPDSNTLASGSDDKAIRLWD 162
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 163 RVTGRPKTTarkagqemapLRGHHNYIHCLAFSPKGNILASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSGIDFCRDGTL 242
Cdd:COG2319  191 LATGKLLRT----------LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 243 VVSCSTDGLIRVWDTSTGQCLRTLVHEDNPaVTNVCFSPNGRFVLAFNLDNCIRLWDYVSGSVKKTYQGHCNKSFAIggC 322
Cdd:COG2319  261 LASGSADGTVRLWDLATGELLRTLTGHSGG-VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--A 337

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 340520488 323 FGVlDGEaFIASASEDGDVLLWDVKSKEVLQRVHGHEG----VCFWVDvhGETMVTAGQDGSVKVYR 385
Cdd:COG2319  338 FSP-DGK-TLASGSDDGTVRLWDLATGELLRTLTGHTGavtsVAFSPD--GRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
83-385 2.30e-92

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 284.50  E-value: 2.30e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  83 KARLVLHGHTKAVSQVRISPNGRFIASASADATVKIWDAATGAHMDTLVGHMAGVSCVAWTPDSNTLASGSDDKAIRLWD 162
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 163 RVTGRPKTTarkagqemapLRGHHNYIHCLAFSPKGNILASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSGIDFCRDGTL 242
Cdd:COG2319  191 LATGKLLRT----------LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 243 VVSCSTDGLIRVWDTSTGQCLRTLVHEDNPaVTNVCFSPNGRFVLAFNLDNCIRLWDYVSGSVKKTYQGHCNKSFAIggC 322
Cdd:COG2319  261 LASGSADGTVRLWDLATGELLRTLTGHSGG-VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--A 337

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 340520488 323 FGVlDGEaFIASASEDGDVLLWDVKSKEVLQRVHGHEG----VCFWVDvhGETMVTAGQDGSVKVYR 385
Cdd:COG2319  338 FSP-DGK-TLASGSDDGTVRLWDLATGELLRTLTGHTGavtsVAFSPD--GRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 87-385 1.90e-85

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 262.66  E-value: 1.90e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  87 VLHGHTKAVSQVRISPNGRFIASASADATVKIWDAATGAHMDTLVGHMAGVSCVAWTPDSNTLASGSDDKAIRLWDRVTG 166
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 167 RPKTTarkagqemapLRGHHNYIHCLAFSPKGNILASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSGIDFCRDGTLVVSC 246
Cdd:cd00200   84 ECVRT----------LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 247 STDGLIRVWDTSTGQCLRTLVHEDNPaVTNVCFSPNGRFVLAFNLDNCIRLWDYVSGSVKKTYQGHCNKSFAIggcfGVL 326
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV----AFS 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 340520488 327 DGEAFIASASEDGDVLLWDVKSKEVLQRVHGHEGVCFWVDVH--GETMVTAGQDGSVKVYR 385
Cdd:cd00200  229 PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSpdGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 107-258 1.88e-13

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 72.43  E-value: 1.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 107 IASASADATVKIWDAATGAHMDTLVGHMAGVSCVAWTP-DSNTLASGSDDKAIRLWDRVTGRPKTTARKAGQemaplrgh 185
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-------- 619

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 340520488 186 hnyIHCLAF-SPKGNILASGSYDEAVFLWDVRAGRL-MRSLPAHSDPVSGIDFCRDGTLvVSCSTDGLIRVWDTS 258
Cdd:PLN00181 620 ---ICCVQFpSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTL-VSSSTDNTLKLWDLS 690
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 182-384 1.28e-09

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 59.32  E-value: 1.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  182 LRGHHNYIHCLAFSPKGNILASGSYDEAVFLWDVRAGRLM--RS---------------------LPAHSDPVSGIDFCR 238
Cdd:pfam20426 120 IRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSekRSrntqtefprkdhviaetpfhiLCGHDDIITCLYVSV 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  239 DGTLVVSCSTDGLIRVWDTSTGQCLRTLVHEDNPAVTNVCFSPNGRFVLAFNLDNCIRLWDyVSG----SVKKTYQGHCN 314
Cdd:pfam20426 200 ELDIVISGSKDGTCIFHTLREGRYVRSIRHPSGCPLSKLVASRHGRIVLYADDDLSLHLYS-INGkhiaSSESNGRLNCI 278

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 340520488  315 KsfaIGGCfgvldGEaFIASASEDGDVLLWDVKSKEVLQRVHGHEGVCFWVDVHGETMVTAG-QDGSVKVY 384
Cdd:pfam20426 279 E---LSSC-----GE-FLVCAGDQGQIVVRSMNSLEVVRRYNGIGKIITSLTVTPEECFLAGtKDGSLLVY 340
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 218-256 3.89e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 3.89e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 340520488   218 GRLMRSLPAHSDPVSGIDFCRDGTLVVSCSTDGLIRVWD 256
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 200-293 5.39e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 38.48  E-value: 5.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  200 ILASGSYDEAVFLWDVRAGRLMRSLPAHSDPvSGIDFCRDGTLVVSC-STDGLIRVWDTSTGQCLRTLVHEDNPAVtnVC 278
Cdd:TIGR03866  13 AYVSNEKDNTISVIDTATLKVTRTFPVGQRP-RGITFSKDGKLLYVCaSDSDTIQVIDPATGEVLHTLPSGPDPEQ--FA 89

                          90
                  ....*....|....*
gi 340520488  279 FSPNGRFVLAFNLDN 293
Cdd:TIGR03866  90 LHPNGKILYIANEDD 104
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
83-385 2.30e-92

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 284.50  E-value: 2.30e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  83 KARLVLHGHTKAVSQVRISPNGRFIASASADATVKIWDAATGAHMDTLVGHMAGVSCVAWTPDSNTLASGSDDKAIRLWD 162
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 163 RVTGRPKTTarkagqemapLRGHHNYIHCLAFSPKGNILASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSGIDFCRDGTL 242
Cdd:COG2319  191 LATGKLLRT----------LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 243 VVSCSTDGLIRVWDTSTGQCLRTLVHEDNPaVTNVCFSPNGRFVLAFNLDNCIRLWDYVSGSVKKTYQGHCNKSFAIggC 322
Cdd:COG2319  261 LASGSADGTVRLWDLATGELLRTLTGHSGG-VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--A 337

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 340520488 323 FGVlDGEaFIASASEDGDVLLWDVKSKEVLQRVHGHEG----VCFWVDvhGETMVTAGQDGSVKVYR 385
Cdd:COG2319  338 FSP-DGK-TLASGSDDGTVRLWDLATGELLRTLTGHTGavtsVAFSPD--GRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 87-385 1.90e-85

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 262.66  E-value: 1.90e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  87 VLHGHTKAVSQVRISPNGRFIASASADATVKIWDAATGAHMDTLVGHMAGVSCVAWTPDSNTLASGSDDKAIRLWDRVTG 166
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 167 RPKTTarkagqemapLRGHHNYIHCLAFSPKGNILASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSGIDFCRDGTLVVSC 246
Cdd:cd00200   84 ECVRT----------LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 247 STDGLIRVWDTSTGQCLRTLVHEDNPaVTNVCFSPNGRFVLAFNLDNCIRLWDYVSGSVKKTYQGHCNKSFAIggcfGVL 326
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV----AFS 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 340520488 327 DGEAFIASASEDGDVLLWDVKSKEVLQRVHGHEGVCFWVDVH--GETMVTAGQDGSVKVYR 385
Cdd:cd00200  229 PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSpdGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
83-385 3.15e-85

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 266.01  E-value: 3.15e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  83 KARLVLHGHTKAVSQVRISPNGRFIASASADATVKIWDAATGAHMDTLVGHMAGVSCVAWTPDSNTLASGSDDKAIRLWD 162
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 163 RVTGRpkttarkagqEMAPLRGHHNYIHCLAFSPKGNILASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSGIDFCRDGTL 242
Cdd:COG2319  149 LATGK----------LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 243 VVSCSTDGLIRVWDTSTGQCLRTLVHEDNPaVTNVCFSPNGRFVLAFNLDNCIRLWDYVSGSVKKTYQGHCNKSFAIggC 322
Cdd:COG2319  219 LASGSADGTVRLWDLATGKLLRTLTGHSGS-VRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--A 295

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 340520488 323 FgVLDGEaFIASASEDGDVLLWDVKSKEVLQRVHGHEGVCFWVDVH--GETMVTAGQDGSVKVYR 385
Cdd:COG2319  296 F-SPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
83-348 1.12e-80

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 254.45  E-value: 1.12e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  83 KARLVLHGHTKAVSQVRISPNGRFIASASADATVKIWDAATGAHMDTLVGHMAGVSCVAWTPDSNTLASGSDDKAIRLWD 162
Cdd:COG2319  153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 163 RVTGRPKTTarkagqemapLRGHHNYIHCLAFSPKGNILASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSGIDFCRDGTL 242
Cdd:COG2319  233 LATGKLLRT----------LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKL 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 243 VVSCSTDGLIRVWDTSTGQCLRTLVHEDNPaVTNVCFSPNGRFVLAFNLDNCIRLWDYVSGSVKKTYQGHCNKSFAIggC 322
Cdd:COG2319  303 LASGSDDGTVRLWDLATGKLLRTLTGHTGA-VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV--A 379

                        250       260
                 ....*....|....*....|....*.
gi 340520488 323 FGVlDGEaFIASASEDGDVLLWDVKS 348
Cdd:COG2319  380 FSP-DGR-TLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
84-384 1.11e-68

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 223.25  E-value: 1.11e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  84 ARLVLHGHTKAVSQVRISPNGRFIASASADATVKIWDAATGAHMDTLVGHMAGVSCVAWTPDSNTLASGSDDKAIRLWDR 163
Cdd:COG2319   28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 164 VTGRPKTTarkagqemapLRGHHNYIHCLAFSPKGNILASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSGIDFCRDGTLV 243
Cdd:COG2319  108 ATGLLLRT----------LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 244 VSCSTDGLIRVWDTSTGQCLRTLVHEDNPaVTNVCFSPNGRFVLAFNLDNCIRLWDYVSGSVKKTYQGHCNKSFAIggCF 323
Cdd:COG2319  178 ASGSDDGTVRLWDLATGKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV--AF 254

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 340520488 324 GvLDGEaFIASASEDGDVLLWDVKSKEVLQRVHGHEGVCFWVDVH--GETMVTAGQDGSVKVY 384
Cdd:COG2319  255 S-PDGR-LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-256 7.29e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 178.30  E-value: 7.29e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  80 PNYKARLVLHGHTKAVSQVRISPNGRFIASASADATVKIWDAATGAHMDTLVGHMAGVSCVAWTPDSNTLASGSDDKAIR 159
Cdd:cd00200  123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 160 LWDrvtgrpkttaRKAGQEMAPLRGHHNYIHCLAFSPKGNILASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSGIDFCRD 239
Cdd:cd00200  203 LWD----------LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPD 272

                        170
                 ....*....|....*..
gi 340520488 240 GTLVVSCSTDGLIRVWD 256
Cdd:cd00200  273 GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
101-385 1.55e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 180.88  E-value: 1.55e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 101 SPNGRFIASASADATVKIWDAATGAHMDTLVGHMAGVSCVAWTPDSNTLASGSDDKAIRLWDRVTGRPKTTarkagqema 180
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT--------- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 181 pLRGHHNYIHCLAFSPKGNILASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSGIDFCRDGTLVVSCSTDGLIRVWDTSTG 260
Cdd:COG2319   74 -LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 261 QCLRTLVHEDNpAVTNVCFSPNGRFVLAFNLDNCIRLWDYVSGSVKKTYQGHCNKSFAIggCFGvLDGEaFIASASEDGD 340
Cdd:COG2319  153 KLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGK-LLASGSADGT 227

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 340520488 341 VLLWDVKSKEVLQRVHGHEGVCFWVDVH--GETMVTAGQDGSVKVYR 385
Cdd:COG2319  228 VRLWDLATGKLLRTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLWD 274
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 107-258 1.88e-13

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 72.43  E-value: 1.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 107 IASASADATVKIWDAATGAHMDTLVGHMAGVSCVAWTP-DSNTLASGSDDKAIRLWDRVTGRPKTTARKAGQemaplrgh 185
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-------- 619

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 340520488 186 hnyIHCLAF-SPKGNILASGSYDEAVFLWDVRAGRL-MRSLPAHSDPVSGIDFCRDGTLvVSCSTDGLIRVWDTS 258
Cdd:PLN00181 620 ---ICCVQFpSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTL-VSSSTDNTLKLWDLS 690
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 182-384 1.28e-09

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 59.32  E-value: 1.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  182 LRGHHNYIHCLAFSPKGNILASGSYDEAVFLWDVRAGRLM--RS---------------------LPAHSDPVSGIDFCR 238
Cdd:pfam20426 120 IRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSekRSrntqtefprkdhviaetpfhiLCGHDDIITCLYVSV 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  239 DGTLVVSCSTDGLIRVWDTSTGQCLRTLVHEDNPAVTNVCFSPNGRFVLAFNLDNCIRLWDyVSG----SVKKTYQGHCN 314
Cdd:pfam20426 200 ELDIVISGSKDGTCIFHTLREGRYVRSIRHPSGCPLSKLVASRHGRIVLYADDDLSLHLYS-INGkhiaSSESNGRLNCI 278

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 340520488  315 KsfaIGGCfgvldGEaFIASASEDGDVLLWDVKSKEVLQRVHGHEGVCFWVDVHGETMVTAG-QDGSVKVY 384
Cdd:pfam20426 279 E---LSSC-----GE-FLVCAGDQGQIVVRSMNSLEVVRRYNGIGKIITSLTVTPEECFLAGtKDGSLLVY 340
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 218-256 3.89e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 3.89e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 340520488   218 GRLMRSLPAHSDPVSGIDFCRDGTLVVSCSTDGLIRVWD 256
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 123-162 6.66e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 6.66e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 340520488   123 TGAHMDTLVGHMAGVSCVAWTPDSNTLASGSDDKAIRLWD 162
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 87-120 7.20e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 7.20e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 340520488    87 VLHGHTKAVSQVRISPNGRFIASASADATVKIWD 120
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
218-256 1.97e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 1.97e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 340520488  218 GRLMRSLPAHSDPVSGIDFCRDGTLVVSCSTDGLIRVWD 256
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
129-162 2.02e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 2.02e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 340520488  129 TLVGHMAGVSCVAWTPDSNTLASGSDDKAIRLWD 162
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
87-120 2.23e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 2.23e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 340520488   87 VLHGHTKAVSQVRISPNGRFIASASADATVKIWD 120
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 176-214 3.04e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 3.04e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 340520488   176 GQEMAPLRGHHNYIHCLAFSPKGNILASGSYDEAVFLWD 214
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 130-256 3.40e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 55.28  E-value: 3.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 130 LVGHMAGVSCVAWTP-DSNTLASGSDDKAIRLWDRVT-GRPKTTArkagQEMAPLRGHHNYIHCLAFSPKG-NILASGSY 206
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEeGLTQNIS----DPIVHLQGHTKKVGIVSFHPSAmNVLASAGA 146

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 340520488 207 DEAVFLWDVRAGRLMRSLPAHSDPVSGIDFCRDGTLVVSCSTDGLIRVWD 256
Cdd:PTZ00421 147 DMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
58-260 5.51e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.46  E-value: 5.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  58 SRSNSFSPEPQQQLTPPRELPKPNYKARLVLHGHTKAVSQVRISPNGRFI-ASASADATVKIWDAATGAHMDTL-VGhmA 135
Cdd:COG3391   33 GGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVIDLATGKVVATIpVG--G 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 136 GVSCVAWTPDSNTL-ASGSDDKAIRLWDRVTGRPKTTArKAGqemaplrghhNYIHCLAFSPKGNILASGSYDEA----- 209
Cdd:COG3391  111 GPRGLAVDPDGGRLyVADSGNGRVSVIDTATGKVVATI-PVG----------AGPHGIAVDPDGKRLYVANSGSNtvsvi 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 340520488 210 VFLWDVRAGRLMRSLPAHSDPVsGIDFCRDGTLVV--------SCSTDGLIRVWDTSTG 260
Cdd:COG3391  180 VSVIDTATGKVVATIPVGGGPV-GVAVSPDGRRLYvanrgsntSNGGSNTVSVIDLATL 237
WD40 pfam00400
WD domain, G-beta repeat;
176-214 1.05e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.05e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 340520488  176 GQEMAPLRGHHNYIHCLAFSPKGNILASGSYDEAVFLWD 214
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 101-235 1.34e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 101 SPNGRFIASASADATVKIWDAATGA-HMDTLVGHMAGVSCVAWTpDSNTLASGSDDKAIRLWDrvtgrpkTTARKAGQEM 179
Cdd:PLN00181 627 SESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWD-------LSMSISGINE 698

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 180 APLR---GHHNYIHCLAFSPKGNILASGSYDEAVFLW-DVRAGRLMRSLPAHSDPVSGID 235
Cdd:PLN00181 699 TPLHsfmGHTNVKNFVGLSVSDGYIATGSETNEVFVYhKAFPMPVLSYKFKTIDPVSGLE 758
PTZ00421 PTZ00421
coronin; Provisional
 74-162 1.58e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.28  E-value: 1.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  74 PRELPKPNYKARLV-LHGHTKAVSQVRISPNGR-FIASASADATVKIWDAATGAHMDTLVGHMAGVSCVAWTPDSNTLAS 151
Cdd:PTZ00421 106 PEEGLTQNISDPIVhLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCT 185

                         90
                 ....*....|.
gi 340520488 152 GSDDKAIRLWD 162
Cdd:PTZ00421 186 TSKDKKLNIID 196
PTZ00421 PTZ00421
coronin; Provisional
 109-257 2.46e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 2.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 109 SASADATVKIWD-------AATGAHMDTLVGHMAGVSCVAWTPDS-NTLASGSDDKAIRLWDRVTGRPKTTarkagqema 180
Cdd:PTZ00421  93 TASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEV--------- 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 181 pLRGHHNYIHCLAFSPKGNILASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSG-IDFCRDGTLVVS--CSTDGL--IRVW 255
Cdd:PTZ00421 164 -IKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQrCLWAKRKDLIITlgCSKSQQrqIMLW 242


                 ..
gi 340520488 256 DT 257
Cdd:PTZ00421 243 DT 244
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 201-344 8.91e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 8.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 201 LASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSGIDFCR-DGTLVVSCSTDGLIRVWDTSTGQCLRTLVHEDNpaVTNVCF 279
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQF 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 280 -SPNGRfVLAF-------------------------------------------NLDNCIRLWDY---VSG---SVKKTY 309
Cdd:PLN00181 626 pSESGR-SLAFgsadhkvyyydlrnpklplctmighsktvsyvrfvdsstlvssSTDNTLKLWDLsmsISGineTPLHSF 704

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 340520488 310 QGHCNKSFAIGgcFGVLDGeaFIASASEDGDVLLW 344
Cdd:PLN00181 705 MGHTNVKNFVG--LSVSDG--YIATGSETNEVFVY 735
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 91-215 2.16e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 2.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  91 HTKAVSQVRISP-NGRFIASASADATVKIWDAATGAHMDTlVGHMAGVSCVAWTPDS-NTLASGSDDKAIRLWDrvtgrp 168
Cdd:PLN00181 574 HEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGT-IKTKANICCVQFPSESgRSLAFGSADHKVYYYD------ 646

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 340520488 169 kttARKAGQEMAPLRGHHNYIHCLAFSpKGNILASGSYDEAVFLWDV 215
Cdd:PLN00181 647 ---LRNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDL 689
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 189-300 2.34e-05

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 44.96  E-value: 2.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  189 IHCLAFSPKGN--ILASGSYDEAVFLWDVRaGRLMRSLPAHsdPVSGIDFCRDGTLVVSC---STDGLIRVWDTSTGQCL 263
Cdd:pfam08662  62 IHDVAWSPNGKefAVIYGYMPAKVSFFDLK-GNVIHSFGEQ--PRNTIFWSPFGRLVLLAgfgNLAGDIEFWDVVNKKKI 138

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 340520488  264 RTLVHEDnpavTNVC-FSPNGRFVLAFNL------DNCIRLWDY 300
Cdd:pfam08662 139 ATAEASN----ATLCeWSPDGRYFLTATTaprlrvDNGFKIWHY 178
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 191-285 2.63e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 45.65  E-value: 2.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 191 CLAFSPKGNILASGSYDEAVFLWDVRAGRLmRSLPAHSDPVSGIDFCRDGTLVVsCSTDGLIRVWDTSTGQcLRTLVHED 270
Cdd:COG3386   12 GPVWDPDGRLYWVDIPGGRIHRYDPDGGAV-EVFAEPSGRPNGLAFDPDGRLLV-ADHGRGLVRFDPADGE-VTVLADEY 88

                         90
                 ....*....|....*...
gi 340520488 271 NPAVT---NVCFSPNGRF 285
Cdd:COG3386   89 GKPLNrpnDGVVDPDGRL 106
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
198-385 4.00e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.69  E-value: 4.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 198 GNILASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSGIDFCRDG-TLVVSCSTDGLIRVWDTSTGQCLRTLVHEDNPavTN 276
Cdd:COG3391   37 LAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGrRLYVANSGSGRVSVIDLATGKVVATIPVGGGP--RG 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 277 VCFSPNGRFVLAFNL-DNCIRLWDYVSGSVKKTyqghcnksFAIG-GCFGVL---DGEAFIASASEDGD----VLLWDVK 347
Cdd:COG3391  115 LAVDPDGGRLYVADSgNGRVSVIDTATGKVVAT--------IPVGaGPHGIAvdpDGKRLYVANSGSNTvsviVSVIDTA 186

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 340520488 348 SKEVLQRVHGHE---GVCFWVD------VHGETMVTAGQDGSVKVYR 385
Cdd:COG3391  187 TGKVVATIPVGGgpvGVAVSPDgrrlyvANRGSNTSNGGSNTVSVID 233
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 140-237 4.45e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.88  E-value: 4.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  140 VAWTPDSNTLASGSDDKAIRL----WDRVTGrpkttarkagqemAPLRGHHNYIHCLAFSPKGNILASGSYDEAVFLWDV 215
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLhrlnWQRVWT-------------LSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDA 67

                          90       100
                  ....*....|....*....|..
gi 340520488  216 RAGRLMRSLPAHSDPVSGIDFC 237
Cdd:pfam12894  68 ENGKIVHHFSAGSDLITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 259-299 9.46e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 9.46e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 340520488   259 TGQCLRTLVHEDNPaVTNVCFSPNGRFVLAFNLDNCIRLWD 299
Cdd:smart00320   1 SGELLKTLKGHTGP-VTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
260-299 3.95e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.95e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 340520488  260 GQCLRTLVHEDNPaVTNVCFSPNGRFVLAFNLDNCIRLWD 299
Cdd:pfam00400   1 GKLLKTLEGHTGS-VTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 88-307 5.34e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.24  E-value: 5.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  88 LHGHTKAVSQVRISP-NGRFIASASADATVKIWDAatgAHMD-----------TLVGHMAGVSCVAWTP-DSNTLASGSD 154
Cdd:PTZ00420  70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEI---PHNDesvkeikdpqcILKGHKKKISIIDWNPmNYYIMCSSGF 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 155 DKAIRLWDrvtgrpKTTARKAGQEMAPLRghhnyIHCLAFSPKGNILASGSYDEAVFLWDVRAGRLMRSLPAHS------ 228
Cdd:PTZ00420 147 DSFVNIWD------IENEKRAFQINMPKK-----LSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDggkntk 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488 229 ----DPVSGIDFCrdgTLVVSCSTDGL--IRVWD---TSTGQCLRTLVHEDNPAVTNVCFSPNGRFVLAFNLDNCiRLWD 299
Cdd:PTZ00420 216 niwiDGLGGDDNY---ILSTGFSKNNMreMKLWDlknTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNC-RYYQ 291


                 ....*...
gi 340520488 300 YVSGSVKK 307
Cdd:PTZ00420 292 HSLGSIRK 299
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 90-143 1.02e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.03  E-value: 1.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 340520488   90 GHTKAVSQVRISPNGRFIASASADATVKIWDAATGAHMDTLVGHMAGVSCVAWT 143
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 185-266 2.81e-03

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 39.75  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  185 HHNYIHCLAFSPKGNILASGSYDEAV-----FLWDVRAGRLMRSLPAHS-DPVSGIDFCRDGT----------LVVSCST 248
Cdd:pfam16529 185 EHSLLVDAAFSPDGTALATASLDGEVkffqiYLFDNRNPRCLHEWKPHDgKPLSSLFFLDNHKkppevqfwrfAITGADN 264

                          90
                  ....*....|....*...
gi 340520488  249 DGLIRVWDTSTGQCLRTL 266
Cdd:pfam16529 265 NSELKLWSCESWTCLQTI 282
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 200-293 5.39e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 38.48  E-value: 5.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488  200 ILASGSYDEAVFLWDVRAGRLMRSLPAHSDPvSGIDFCRDGTLVVSC-STDGLIRVWDTSTGQCLRTLVHEDNPAVtnVC 278
Cdd:TIGR03866  13 AYVSNEKDNTISVIDTATLKVTRTFPVGQRP-RGITFSKDGKLLYVCaSDSDTIQVIDPATGEVLHTLPSGPDPEQ--FA 89

                          90
                  ....*....|....*
gi 340520488  279 FSPNGRFVLAFNLDN 293
Cdd:TIGR03866  90 LHPNGKILYIANEDD 104
Peptidase_S9_N pfam02897
Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded ...
 72-162 8.50e-03

Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded beta-propeller domain protects the catalytic triad of prolyl oligopeptidase (see pfam00326), excluding larger peptides and proteins from proteolysis in the cytosol.


Pssm-ID: 397164 [Multi-domain]  Cd Length: 414  Bit Score: 38.06  E-value: 8.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340520488   72 TPPRELPKPNYKARlvlHGHTKAVSQVRISPNGRFIA----SASADA-TVKIWDAATGAHM-DTLVGhmAGVSCVAWTPD 145
Cdd:pfam02897 106 KPEEVFLDPNTLSE---DGTFTALGGFAFSPDGRLLAyslsLSGSDWyTIRFRDVETGEDLpDVLEG--VKFSGIVWAPD 180

                          90
                  ....*....|....*..
gi 340520488  146 SNTLASGSDDKAIRLWD 162
Cdd:pfam02897 181 GKGFFYTRYDKPDERSD 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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