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Conserved domains on  [gi|340518587|gb|EGR48828|]
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N-terminal binuclear Zn cluster-containing/DNA binding domain-containing protein [Trichoderma reesei QM6a]

Protein Classification

Zn(II)2Cys6 transcription factor( domain architecture ID 10637820)

Zn(II)2Cys6 transcription factor domain-containing proteins form a subclass of zinc finger proteins found exclusively in fungi

Gene Ontology:  GO:0008270|GO:0000981
PubMed:  9290251

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 251-679 5.43e-63

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


:

Pssm-ID: 213391  Cd Length: 410  Bit Score: 219.24  E-value: 5.43e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587 251 PPKDVARKLCYYSLSCATCLVRIVHVPSFYEKfdyiYDRQHEPTSHDDTQFLALFYAVLALGCMYSnlddsSSSGVTYRQ 330
Cdd:cd12148    1 PPREVADRLLDLYFENVHPLFPILHRPTFLRD----LESLYSDPSSLSPASLALLLAVLALAALSL-----PDSELRGES 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587 331 AIDEGVKYYKIARSLLRDVTECR-SLISIQTLVFMILFLQSTANLNTCYSFVGIALRSALRIGLHRNLQHER-IGNIEQQ 408
Cdd:cd12148   72 RRSLAERYYEAARQLLDLALFLPpSLETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSLGLHRDPSSLPgLSPFERE 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587 409 VRRRVFYVIRQMDIYVSAMLGFPLLLNSEDVDQQYPLEVDDEFIRPEGIIQPAPGTASFFQAFNAHTRLMEILGKITKYI 488
Cdd:cd12148  152 LRRRLWWSLYILDRLLSLSLGRPPSISDEDIDVPLPSNEDDELSPSSSPPPPPSEEPTSLSFFIALIRLARILGRILRLL 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587 489 YPTKgagqtvmrgnkpSSTYLISYSKIKEIETDLHNWFERLPEAWRPSPD--GPIEVVRVRHLLRFAYAHVQLVLYRPFL 566
Cdd:cd12148  232 YSPR------------ASSPEDSLETILELDAELEEWRASLPPELRLDSSslESPSLLPQRLLLHLLYHLLLILLHRPFL 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587 567 HYVSPRLSQNSRIDELSYACAAAAisvsRNIVHIGLEIRKQRVLSGPYWFMLYTEFFSVLSLVFYAIENPEKPGSAEVLA 646
Cdd:cd12148  300 LRSLSSLSPSSSSAESRRACLEAA----REILELLRLLLSSSLLLLLWWFLLYYLFSAALVLLLALLLRPSSSELEEARS 375

                        410       420       430
                 ....*....|....*....|....*....|....
gi 340518587 647 DARAGRQMIADLAEKS-LSAERVTNTLKVLFDQL 679
Cdd:cd12148  376 LLERALELLERLSERWpRLARRALRLLERLLARA 409
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 54-95 4.45e-16

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


:

Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 72.78  E-value: 4.45e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 340518587    54 RRVTRACDECRRKKIKCDGKQP-CTHCSVYSYECTYDKPSNRR 95
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPpCSNCIKLGLECTYSDSKKRK 43
ZIP_Gal4p-like super family cl22421
Leucine zipper Dimerization domain of Gal4p-like transcription factors; The Gal4p family of ...
 106-144 1.17e-03

Leucine zipper Dimerization domain of Gal4p-like transcription factors; The Gal4p family of transcriptional activators contain an N-terminal DNA-binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner. Included in this family are Saccharomyces cerevisiae Gal4p, Hap1p, Put3p, Ppr1p and Sip4p, Neurospora crassa acu-15, and Colletotrichum acutatum Nir1, among others. Gal4p functions in the induction of GAL genes in the presence of galactose; GAL proteins are responsible for the transport of galactose into the cell and for its metabolism through the glycolytic pathway. Hap1p promotes transcription of genes required for respiration and controlling oxidative damage in response to heme. Put3p activates the transcription of the PUT1 and PUT2 genes in the presence of proline, allowing yeast cells to use proline as a nitrogen source. Ppr1p activates transcription of the URA1, URA3, and URA4 genes, which encode enzymes involved in the regulation of pyrimidine levels. Sip4p activates target genes under conditions of glucose deprivation. Acu-15 is involved in regulating acetate utilization while Nir1 plays a role during nitrogen-starvation conditions.


The actual alignment was detected with superfamily member cd14654:

Pssm-ID: 277561  Cd Length: 47  Bit Score: 37.58  E-value: 1.17e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 340518587 106 LESRLQRAESLLRKFVPDIDLADPSLDPAIQQEFHNRER 144
Cdd:cd14654    8 VENRLEKLEALLRQLLPGVDIDELLESPSELEDDDPLDD 46
 
Name Accession Description Interval E-value
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 251-679 5.43e-63

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 219.24  E-value: 5.43e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587 251 PPKDVARKLCYYSLSCATCLVRIVHVPSFYEKfdyiYDRQHEPTSHDDTQFLALFYAVLALGCMYSnlddsSSSGVTYRQ 330
Cdd:cd12148    1 PPREVADRLLDLYFENVHPLFPILHRPTFLRD----LESLYSDPSSLSPASLALLLAVLALAALSL-----PDSELRGES 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587 331 AIDEGVKYYKIARSLLRDVTECR-SLISIQTLVFMILFLQSTANLNTCYSFVGIALRSALRIGLHRNLQHER-IGNIEQQ 408
Cdd:cd12148   72 RRSLAERYYEAARQLLDLALFLPpSLETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSLGLHRDPSSLPgLSPFERE 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587 409 VRRRVFYVIRQMDIYVSAMLGFPLLLNSEDVDQQYPLEVDDEFIRPEGIIQPAPGTASFFQAFNAHTRLMEILGKITKYI 488
Cdd:cd12148  152 LRRRLWWSLYILDRLLSLSLGRPPSISDEDIDVPLPSNEDDELSPSSSPPPPPSEEPTSLSFFIALIRLARILGRILRLL 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587 489 YPTKgagqtvmrgnkpSSTYLISYSKIKEIETDLHNWFERLPEAWRPSPD--GPIEVVRVRHLLRFAYAHVQLVLYRPFL 566
Cdd:cd12148  232 YSPR------------ASSPEDSLETILELDAELEEWRASLPPELRLDSSslESPSLLPQRLLLHLLYHLLLILLHRPFL 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587 567 HYVSPRLSQNSRIDELSYACAAAAisvsRNIVHIGLEIRKQRVLSGPYWFMLYTEFFSVLSLVFYAIENPEKPGSAEVLA 646
Cdd:cd12148  300 LRSLSSLSPSSSSAESRRACLEAA----REILELLRLLLSSSLLLLLWWFLLYYLFSAALVLLLALLLRPSSSELEEARS 375

                        410       420       430
                 ....*....|....*....|....*....|....
gi 340518587 647 DARAGRQMIADLAEKS-LSAERVTNTLKVLFDQL 679
Cdd:cd12148  376 LLERALELLERLSERWpRLARRALRLLERLLARA 409
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 273-527 9.60e-29

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


Pssm-ID: 397964  Cd Length: 262  Bit Score: 116.44  E-value: 9.60e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587  273 IVHVPSFYEKFDYIYDRQHEPTSHddtqflALFYAVLALGCMYSNlDDSSSSGVTYRQAIDEGVKYYKIARSLL--RDVT 350
Cdd:pfam04082  14 ILHRPSFLRDYFELFSSPSNYASP------LLLLAILALGALFSE-SPTARSSSSLTDEAADGIHFFLRALILIheDFSS 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587  351 ECRSLISIQTLVFMILFLQSTANLNTCYSFVGIALRSALRIGLHRNLQHERIGN----IEQQVRRRVFYVIRQMDIYVSA 426
Cdd:pfam04082  87 PSSSLWILQALLLLELYELGTGDRKLHWRYHGLAIRLARSLGLHRDPSYVSPSWklwiEEAELRRRLFWACFYLDRLISL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587  427 MLGFPLLLNSEDVDQQYPLEVDDEFI---RPEGIIQPAPGTASFFQAFNAHTRLMEILGKITKYIYPtkgagqtvmRGNK 503
Cdd:pfam04082 167 ILGRPPLLSDSDIDLPLPCDDDDLWEsdsADEVTLPLISLESKSIKPPLFLIKLSKILSKILGSLLS---------IRST 237

                         250       260
                  ....*....|....*....|....*
gi 340518587  504 PSSTYLI-SYSKIKEIETDLHNWFE 527
Cdd:pfam04082 238 LDQRDLQlKLSWVRELERALDNWRK 262
Fungal_trans smart00906
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 354-449 9.01e-20

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and other transcription proteins regulating a variety of cellular and metabolic processes.


Pssm-ID: 214903 [Multi-domain]  Cd Length: 93  Bit Score: 84.81  E-value: 9.01e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587   354 SLISIQTLVFMILFLQsTANLNTCYSFVGIALRSALRIGLHRNLQHERIGNIEQqvRRRVFYVIRQMDIYVSAMLGFPLL 433
Cdd:smart00906   1 SLETVQALLLALLSLY-LGGRDAAWMLLGLAIRLAQALGLHRDPSNSDLEERER--RRRRFWWLYILDRLLSLSLGRPPL 77

                           90
                   ....*....|....*.
gi 340518587   434 LNSEDVDQQYPLEVDD 449
Cdd:smart00906  78 IDDDDIDVPLPSDLDD 93
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 54-95 4.45e-16

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 72.78  E-value: 4.45e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 340518587    54 RRVTRACDECRRKKIKCDGKQP-CTHCSVYSYECTYDKPSNRR 95
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPpCSNCIKLGLECTYSDSKKRK 43
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
58-95 5.23e-14

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 66.55  E-value: 5.23e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 340518587   58 RACDECRRKKIKCDGKQP-CTHCSVYSYECTYDKPSNRR 95
Cdd:pfam00172   1 TACDNCRKRKVKCDGKKPaCSRCIKNGLECTYSRKSKKS 39
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 55-89 5.84e-14

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 66.53  E-value: 5.84e-14
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 340518587  55 RVTRACDECRRKKIKCDG-KQPCTHCSVYSYECTYD 89
Cdd:cd00067    1 RVRRACDRCRRRKIKCDGeKPPCSNCIKLGLECTYS 36
ZIP_Gal4 cd14654
Leucine zipper Dimerization domain of transcription factor Gal4 and similar fungal proteins; ...
 106-144 1.17e-03

Leucine zipper Dimerization domain of transcription factor Gal4 and similar fungal proteins; Gal4p is one of several GAL proteins required for the growth of yeast on galactose; GAL proteins are responsible for the transport of galactose into the cell and for its metabolism through the glycolytic pathway. Gal4p functions in the induction of GAL genes in the presence of galactose through an upstream activating sequence (UAS) present in their promoters. The Gal4p family of transcriptional activators contain an N-terminal DNA binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner.


Pssm-ID: 271238  Cd Length: 47  Bit Score: 37.58  E-value: 1.17e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 340518587 106 LESRLQRAESLLRKFVPDIDLADPSLDPAIQQEFHNRER 144
Cdd:cd14654    8 VENRLEKLEALLRQLLPGVDIDELLESPSELEDDDPLDD 46
 
Name Accession Description Interval E-value
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 251-679 5.43e-63

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 219.24  E-value: 5.43e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587 251 PPKDVARKLCYYSLSCATCLVRIVHVPSFYEKfdyiYDRQHEPTSHDDTQFLALFYAVLALGCMYSnlddsSSSGVTYRQ 330
Cdd:cd12148    1 PPREVADRLLDLYFENVHPLFPILHRPTFLRD----LESLYSDPSSLSPASLALLLAVLALAALSL-----PDSELRGES 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587 331 AIDEGVKYYKIARSLLRDVTECR-SLISIQTLVFMILFLQSTANLNTCYSFVGIALRSALRIGLHRNLQHER-IGNIEQQ 408
Cdd:cd12148   72 RRSLAERYYEAARQLLDLALFLPpSLETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSLGLHRDPSSLPgLSPFERE 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587 409 VRRRVFYVIRQMDIYVSAMLGFPLLLNSEDVDQQYPLEVDDEFIRPEGIIQPAPGTASFFQAFNAHTRLMEILGKITKYI 488
Cdd:cd12148  152 LRRRLWWSLYILDRLLSLSLGRPPSISDEDIDVPLPSNEDDELSPSSSPPPPPSEEPTSLSFFIALIRLARILGRILRLL 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587 489 YPTKgagqtvmrgnkpSSTYLISYSKIKEIETDLHNWFERLPEAWRPSPD--GPIEVVRVRHLLRFAYAHVQLVLYRPFL 566
Cdd:cd12148  232 YSPR------------ASSPEDSLETILELDAELEEWRASLPPELRLDSSslESPSLLPQRLLLHLLYHLLLILLHRPFL 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587 567 HYVSPRLSQNSRIDELSYACAAAAisvsRNIVHIGLEIRKQRVLSGPYWFMLYTEFFSVLSLVFYAIENPEKPGSAEVLA 646
Cdd:cd12148  300 LRSLSSLSPSSSSAESRRACLEAA----REILELLRLLLSSSLLLLLWWFLLYYLFSAALVLLLALLLRPSSSELEEARS 375

                        410       420       430
                 ....*....|....*....|....*....|....
gi 340518587 647 DARAGRQMIADLAEKS-LSAERVTNTLKVLFDQL 679
Cdd:cd12148  376 LLERALELLERLSERWpRLARRALRLLERLLARA 409
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 273-527 9.60e-29

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


Pssm-ID: 397964  Cd Length: 262  Bit Score: 116.44  E-value: 9.60e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587  273 IVHVPSFYEKFDYIYDRQHEPTSHddtqflALFYAVLALGCMYSNlDDSSSSGVTYRQAIDEGVKYYKIARSLL--RDVT 350
Cdd:pfam04082  14 ILHRPSFLRDYFELFSSPSNYASP------LLLLAILALGALFSE-SPTARSSSSLTDEAADGIHFFLRALILIheDFSS 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587  351 ECRSLISIQTLVFMILFLQSTANLNTCYSFVGIALRSALRIGLHRNLQHERIGN----IEQQVRRRVFYVIRQMDIYVSA 426
Cdd:pfam04082  87 PSSSLWILQALLLLELYELGTGDRKLHWRYHGLAIRLARSLGLHRDPSYVSPSWklwiEEAELRRRLFWACFYLDRLISL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587  427 MLGFPLLLNSEDVDQQYPLEVDDEFI---RPEGIIQPAPGTASFFQAFNAHTRLMEILGKITKYIYPtkgagqtvmRGNK 503
Cdd:pfam04082 167 ILGRPPLLSDSDIDLPLPCDDDDLWEsdsADEVTLPLISLESKSIKPPLFLIKLSKILSKILGSLLS---------IRST 237

                         250       260
                  ....*....|....*....|....*
gi 340518587  504 PSSTYLI-SYSKIKEIETDLHNWFE 527
Cdd:pfam04082 238 LDQRDLQlKLSWVRELERALDNWRK 262
Fungal_trans smart00906
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 354-449 9.01e-20

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and other transcription proteins regulating a variety of cellular and metabolic processes.


Pssm-ID: 214903 [Multi-domain]  Cd Length: 93  Bit Score: 84.81  E-value: 9.01e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340518587   354 SLISIQTLVFMILFLQsTANLNTCYSFVGIALRSALRIGLHRNLQHERIGNIEQqvRRRVFYVIRQMDIYVSAMLGFPLL 433
Cdd:smart00906   1 SLETVQALLLALLSLY-LGGRDAAWMLLGLAIRLAQALGLHRDPSNSDLEERER--RRRRFWWLYILDRLLSLSLGRPPL 77

                           90
                   ....*....|....*.
gi 340518587   434 LNSEDVDQQYPLEVDD 449
Cdd:smart00906  78 IDDDDIDVPLPSDLDD 93
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 54-95 4.45e-16

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 72.78  E-value: 4.45e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 340518587    54 RRVTRACDECRRKKIKCDGKQP-CTHCSVYSYECTYDKPSNRR 95
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPpCSNCIKLGLECTYSDSKKRK 43
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
58-95 5.23e-14

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 66.55  E-value: 5.23e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 340518587   58 RACDECRRKKIKCDGKQP-CTHCSVYSYECTYDKPSNRR 95
Cdd:pfam00172   1 TACDNCRKRKVKCDGKKPaCSRCIKNGLECTYSRKSKKS 39
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 55-89 5.84e-14

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 66.53  E-value: 5.84e-14
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 340518587  55 RVTRACDECRRKKIKCDG-KQPCTHCSVYSYECTYD 89
Cdd:cd00067    1 RVRRACDRCRRRKIKCDGeKPPCSNCIKLGLECTYS 36
ZIP_Gal4 cd14654
Leucine zipper Dimerization domain of transcription factor Gal4 and similar fungal proteins; ...
 106-144 1.17e-03

Leucine zipper Dimerization domain of transcription factor Gal4 and similar fungal proteins; Gal4p is one of several GAL proteins required for the growth of yeast on galactose; GAL proteins are responsible for the transport of galactose into the cell and for its metabolism through the glycolytic pathway. Gal4p functions in the induction of GAL genes in the presence of galactose through an upstream activating sequence (UAS) present in their promoters. The Gal4p family of transcriptional activators contain an N-terminal DNA binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner.


Pssm-ID: 271238  Cd Length: 47  Bit Score: 37.58  E-value: 1.17e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 340518587 106 LESRLQRAESLLRKFVPDIDLADPSLDPAIQQEFHNRER 144
Cdd:cd14654    8 VENRLEKLEALLRQLLPGVDIDELLESPSELEDDDPLDD 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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