|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
9-409 |
9.47e-92 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 281.00 E-value: 9.47e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 9 RWMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSA 88
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 89 FTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVF 168
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 169 YIFGAVGILMAVLWAIIAKdlpeqhrmvneaekrfimenrdivatekssppwndffkrfSFYAIAIQYFVVQFIITLFLI 248
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYLR----------------------------------------QVWGLALGYFGINYALYGLLT 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 249 WLPTYLTEVFHVNFKEMS-ISSLPWLLMFFLILSAGAISDRVLGLgrskfvARGVIAIAGFIVFAVSIIFAVRTGNLYVS 327
Cdd:cd17319 201 WLPTYLKQARGFSLKQVGlLAAIPFLAGAIGMILGGRLSDRLLRG------ARRLVIIIGLLLAAVGLLLAYLTTSPVVA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 328 IFWLSLGLGGIGISMGMSWAAATD-LGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLG-WTMTFQLLIVPAVIAVIM 405
Cdd:cd17319 275 VILLSLAGFGIGAASPVFWSLPADlLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALL 354
|
....
gi 320144554 406 WFYV 409
Cdd:cd17319 355 VLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-412 |
8.03e-69 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 222.05 E-value: 8.03e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 2 KEKRTNVRWMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITI 81
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 82 ALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNA 161
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 162 FNWQAVFYIFGAVGILMAVLwaiiakdlpeqhrmvneaekrfimenrdivatekssppwndffkrfSFYAIAIQYFVVQF 241
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL----------------------------------------------RFWLLALAYFLVYF 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 242 IITLFLIWLPTYLTEVFHVNFKEMS-ISSLPWLLMFFLILSAGAISDRVLGLGRskfvargVIAIAGFIVFAVSIIFAVR 320
Cdd:COG2271 195 ALYGFLTWLPTYLVEVRGLSLAQAGlLLSLPFLAGIVGSLLGGWLSDRLGRRRK-------LVLAIGLLLAALALLLLAL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 321 TGNLYVSIFWLSLGLGGIGISMGMSWAAATDL-GRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPA 399
Cdd:COG2271 268 LPSPALAIALLFLAGFGLGGAFGLLWALAAELfPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALA 347
|
410
....*....|...
gi 320144554 400 VIAVIMWFYVKPD 412
Cdd:COG2271 348 LLAALLALLLLRE 360
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
20-409 |
8.65e-55 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 186.77 E-value: 8.65e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 20 GVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNH 99
Cdd:TIGR00893 3 TVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 100 GLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMA 179
Cdd:TIGR00893 83 VSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGIIWG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 180 VLWAIIAKDLPEQHRMVNEAEKRFIMENRDIVATEK--SSPPWNDF---FKRFSFYAIAIQYFVVQFIITLFLIWLPTYL 254
Cdd:TIGR00893 163 VLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKgpSTPKKYQIkelLKDRRVWGLALGQFLVNIGLGFFLTWFPTYL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 255 TEVFHVNFKEMS-ISSLPWLLMFFLILSAGAISDRVLGLGRSKFVARGViAIAGFIVFAVSIIFAVRTGNLYVSIFWLSL 333
Cdd:TIGR00893 243 VQERGLSILEAGfMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKT-AIIAGLVLSLLMFATNYVNIPYAALALVAL 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320144554 334 GLGGIGIsMGMSWAAATD-LGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLG-WTMTFQLLIVPAVIAVIMWFYV 409
Cdd:TIGR00893 322 GFFGLGA-GAIGWALISDnAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGsFAGALMVVAALALIGALSYLLL 398
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
14-397 |
4.61e-54 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 183.52 E-value: 4.61e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 14 LAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILT 93
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 94 GMIKNHGL--IYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIF 171
Cdd:cd17380 82 PLLAYSSLplLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 172 GAVGILMAVLWAIIAKdlpeqhrmvneaekrfimenrdivatekssppwndffkrfSFYAIAIQYFVVQFIITLFLIWLP 251
Cdd:cd17380 162 GLLGLLWALVWLIYLP----------------------------------------PVWAIIVAHFCMNWGFYILLSWLP 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 252 TYLTEVFHVNFKEMSISSLPWLLMFFLILSAGAISDRVLGLGRSKFVARGVIAIAGFIVFAVSIIFAVRTGNLYVSIFWL 331
Cdd:cd17380 202 TYFHEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCM 281
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320144554 332 SLGLGGIGISMGMSWAAATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLG-WTMTFQLLIV 397
Cdd:cd17380 282 SVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGsWSLVFVLAAV 348
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
7-410 |
1.85e-46 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 164.28 E-value: 1.85e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 7 NVRWMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWW 86
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 87 SAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQA 166
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 167 VFYIFGAVGILMAVLWAIIAKDLPEQHRmvneaekrfimenrdiVATEKSSPPWNDFFKRFSFYAIAIQYFVVQFIITLF 246
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDPPAGAA----------------AAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 247 LIWLPTYLTEVFHVNFKE-MSISSLPWLLMFFLILSAGAISDRVlglGRSKfvargVIAIAGFIVFAVSIIFAVRTGNLY 325
Cdd:COG2223 225 SSWLPPYLVDQFGLSAATaGLLAALFALLGALGRPLGGWLSDRI---GGRR-----VLLIVFALMALGLLLLALALGSLW 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 326 VSIFWLSLGLGGIGISMGMSWAAATDL-GRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLG-WTMTFQLLIVPAVIAV 403
Cdd:COG2223 297 LFLVLFLLLGLALGGGNGAVFALVPDIfPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVAL 376
|
....*..
gi 320144554 404 IMWFYVK 410
Cdd:COG2223 377 VLTLLLY 383
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
44-409 |
3.38e-40 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 147.77 E-value: 3.38e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 44 TKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYL--VRFLFGVGEAPMYPSNA 121
Cdd:cd17318 54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALivLRILQGLAQGVTFPAMH 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 122 VFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIakdlpeqhrmvneaek 201
Cdd:cd17318 134 ALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFL---------------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 202 rfimenrdivateksSPPwndffkrfsFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSI-SSLPWLLMFFLIL 280
Cdd:cd17318 198 ---------------VLP---------VWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFlSSLPYLAMWICSI 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 281 SAGAISDRVLGLGR-SKFVARGVIAIAGFI---VFAVSIIFAVRTGNLYVSIFWLSLGLGGIGISmGMSwAAATDLGRNF 356
Cdd:cd17318 254 VGGYLADWLRSRGIlSTTTVRKLFTSIGFLgpgVFLIALGYLGSNATLAVVFLTLSVGLSGACYS-GFL-VNHLDLAPNY 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 320144554 357 SGTVSGWMNLWGNIGALISPLLAGLFVEH----LGWTMTFQLLIVPAVIAVImwFYV 409
Cdd:cd17318 332 AGTLMGITNTAATIAGIISPLIVGAIVKNdqtiGQWRIVFFISAAIYILGAI--FYL 386
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
49-404 |
3.85e-32 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 126.78 E-value: 3.85e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 49 GLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLV--RFLFGVGEAPMYPSNAVFNSF 126
Cdd:TIGR00894 79 GLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVfcRVIQGLAQGSVSPATHKIIVK 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 127 WFSKNEKGRASSALLAGSYFGPVLA-PIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIAKDLPEQHRMVNEAEKRFIm 205
Cdd:TIGR00894 159 WAPPKERSRLLGMSTSGFQLGTFIFlPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYI- 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 206 eNRDIVATEKSSP---PWNDFFKRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSI-SSLPWLLMFFLILS 281
Cdd:TIGR00894 238 -NSSLQGQKGSTRqslPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLlSSLPYLFAWLCSIF 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 282 AGAISDRVLGLGR-SKFVARGVI-AIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGGIGISMGMSWAAATDLGRNFSGT 359
Cdd:TIGR00894 317 AGYLADFLKSSKTlSLTAARKIFnGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGF 396
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 320144554 360 VSGWMNLWGNIGALISPLLAGLFV----EHLgWTMTFQLLIVPAVIAVI 404
Cdd:TIGR00894 397 IKGITGLPGFIGGLIASTLAGNILsqdsKNV-WLIVFLIMAFVNILCVI 444
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
16-376 |
4.61e-32 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 124.45 E-value: 4.61e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 16 FFFIGVIAYMDRANISYIAKQ-MMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTG 94
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 95 MIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAV 174
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 175 GILMAVLWAIIAKDLPEQHRMVNEAEKRFIMEnrdivateksspPWNDFFKRFSFYAIAIqYFVVQFIITLFLIWLPTYL 254
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIV------------AWKALLRDPVLWLLLA-LLLFGFAFFGLLTYLPLYQ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 255 TEVFHVNFKEMSISSLPWLLMFFLILSAGAISDRVlglgrsKFVARGVIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLG 334
Cdd:pfam07690 228 EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL------GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL 301
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 320144554 335 LGGIGISMGMSWAAATDL-GRNFSGTVSGWMNLWGNIGALISP 376
Cdd:pfam07690 302 GFGFGLVFPALNALVSDLaPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
9-372 |
1.01e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 120.85 E-value: 1.01e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 9 RWMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSA 88
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 89 FTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVF 168
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 169 YIFGAVGILMAVLwaiIAKDLPEQHRmvneaekrfimenrdiVATEKSSPPWNDFFKRFSFYAIAIQYFVVQFIITLFLI 248
Cdd:COG2814 168 LVNAVLALLALLL---LLRLLPESRP----------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 249 WLPTYLTEVFHVNFKEMSISSLPWLLMFFLI-LSAGAISDRvlglgrskfVARGVIAIAGFIVFAVSIIFAVRTGNLYVS 327
Cdd:COG2814 229 YLPLYLQEVLGLSASAAGLLLALFGLGGVLGaLLAGRLADR---------FGRRRLLLIGLLLLALGLLLLALAGSLWLL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 320144554 328 IFWLSLGLGGIGISMGMSWAAATDL-GRNFSGTVSGWMNLWGNIGA 372
Cdd:COG2814 300 LLALFLLGFGFGLLFPLLQALVAELaPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
22-376 |
1.91e-30 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 121.20 E-value: 1.91e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 22 IAYMDRANISYIAKQ-MMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHG 100
Cdd:cd17327 16 LQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 101 LIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAI-----VNAF-NWQAVFYIFGAV 174
Cdd:cd17327 96 GLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVfkilgVGGLaGWRWLFIIEGLI 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 175 GILMAVLWAIIAKDLPEQHRMVNEAEKRFIMENRDIVATEKSSPP-----WNDFFKRFSFYAIAIQYFVVQFIITLFLIW 249
Cdd:cd17327 176 TIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDQKfkwkqIKEAFKDPRTWLLFLFFFCSQITNNGISNF 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 250 LPTYLtevfhvnfKEMSISSLPWLLMFFLILSAGAISDRVLGLGRSKFVARGVIAIAGFIVFAVSIIFAVRTGN---LYV 326
Cdd:cd17327 256 LPLIL--------KSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLAAPNppgAYF 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 320144554 327 SIFWLSLGLGGIGISMgMSWAAATDLGRNFSGTVSGWMNLWGNIGALISP 376
Cdd:cd17327 328 AAYILGGGSYAGFPIL-LSWISSNCAGYTKRATVLAIMLIFYNVGNIVAP 376
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
18-392 |
2.09e-30 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 120.56 E-value: 2.09e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 18 FIGVIA-YMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMI 96
Cdd:TIGR00881 1 FIGYAAyYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 97 KNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYF-GPVLAPIVTIAIVNAFNWQAVFYIFGAVG 175
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 176 ILMAVLWAIIAKDLPEQHRMVNEAEKRFIMENRDIVATEKSSPPWNDFFKRFSF----YAIAIQYFVVQFIITLFLIWLP 251
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLnkvlWYISLGYVFVYVVRTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 252 TYLTEVFHVNFKEMSIS-SLPWLLMFFLILSAGAISDRVLGLGRSkfvARGVIAIAGfIVFAVSIIFAVRTGNLYV-SIF 329
Cdd:TIGR00881 241 LYLTQEKGFSKEKASWAfTLYELGGLVGTLLAGWLSDKLFNGRRG---PLAVFFMAL-IIVSLLVYWLNPAANPLMdLIC 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320144554 330 WLSLGLGGIGISMgMSWAAATDLG-RNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTF 392
Cdd:TIGR00881 317 LFALGFLVYGPQM-LIGVIASELApKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
9-404 |
2.69e-27 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 111.60 E-value: 2.69e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 9 RWMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSA 88
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 89 FTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVF 168
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 169 YIFGAVGILMAVLWAIIAKDlpeqhrmvneaekrfimenrdivateksSPPWndffkrfsFYAIAIQYFVVQFIITLFLI 248
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRD----------------------------SPPY--------VWVLSLAYAFVYIVRYACLD 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 249 WLPTYLTEVFHVNFKEMS-ISSLPWLLMFFLILSAGAISDRVLGLGRSKFvarGVIAIAGFIVFAVSIIFAVrtGNLYVS 327
Cdd:cd17312 205 WGPLYLYEVKGYSLIDAGwFSSLYEVGGIAGTILAGLLSDKLFGGRRAPI---AVIYMLLMTLSLALFWFFP--HNKLLS 279
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320144554 328 IFWLSL-GLGGIGISMGMSWAAATDLGRNF-SGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAVI 404
Cdd:cd17312 280 IVLLFLiGFFVGGPINLIGGAAAQDIGRKEaAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVL 358
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-405 |
2.55e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 109.05 E-value: 2.55e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 16 FFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGM 95
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 96 IKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIV--NAFNWQAVFYIFGA 173
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 174 VGILMAVLWAIIAKDLPEQHRMVNEAEKrfimenrdivaTEKSSPPWNDFFKRFSFYAIAIQYFVVQFIITLFLIWLPTY 253
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEAS-----------SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLF 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 254 LTEVFHvnfkemsISSLPWLLMFFLILSAGAISDRVLGLGRSKFVARGVIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSL 333
Cdd:cd06174 230 LLDLGG-------LSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320144554 334 GLGGIGISMGMSWAAATDLGRNFS-GTVSGWMNLWGNIGALISPLLAG-LFVEHLGWTMTFQLLIVPAVIAVIM 405
Cdd:cd06174 303 LGFGLGGLLPLSFALIAELFPPEIrGTAFGLLNTFGFLGGAIGPLLAGfLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
38-409 |
1.46e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 101.11 E-value: 1.46e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 38 MDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMY 117
Cdd:cd17325 23 AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 118 PSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIAKDLPEQHrmvn 197
Cdd:cd17325 103 PAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPP---- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 198 eaekrfimeNRDIVATEKSSPPWNDFFKRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKE----MSISSLPWL 273
Cdd:cd17325 179 ---------NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQigllFGAQGLASA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 274 LMFFLilsAGAISDRVlglGRSKfvargvIAIAGFIVFAVSIIFAVRTGNLYvsifWLSLGLGGIGISMGMSWAAATDL- 352
Cdd:cd17325 250 LSQPP---AGKLSDRI---GRKP------LILIGLLLSAVALLLLPLATSFW----LLLLLLALLGLGLGLVFPATLALl 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 320144554 353 ----GRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLL-IVPAVIAVIMWFYV 409
Cdd:cd17325 314 adivPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAaALLLLAAVLFLLLR 375
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
17-404 |
1.78e-23 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 101.16 E-value: 1.78e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 17 FFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMI 96
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 97 KNHGLIYLVRFLFGVGEAPMYP--SNAVFNsfWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAV 174
Cdd:cd17475 82 GSYPVLLVLLFLVGAGYGSVQPggGRAIMR--WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 175 GILMAVLWAIIAKDLPEQHR-----MVNEAEKRFIMENRDIvatekssppWNDFFkrFSFYAIAIQYFVVQFiitlfliw 249
Cdd:cd17475 160 SILAAVLFWLFYREPPAASAatesaSTLLRSLKEVLRNRDV---------WLIAI--AGALLVAPQFALLTF-------- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 250 LPTYLTEVFHVnfkemSISSLPWLLMFFLILSA------GAISDRVLGlGRSKFVARGVIAIAGFIVFAVSIIFAVRTGN 323
Cdd:cd17475 221 LLLFLHDHLGL-----SVVAAGALLAVAQLGGAlgriglGRVSDRVFG-GRRRPVLVITAAIAAAALLVLSLLSPGTPLW 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 324 LYVSIFWLsLGLGGIG-ISMGMSWAAATdLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHL-GWTMTFQLLIVPAVI 401
Cdd:cd17475 295 LLVLLLIL-LGLFAIGwNGLYLTLVAES-AGPEQAGTALGLANTINFIGIAIGPPLFGLLVDAThSYAPAWLALALLLVL 372
|
...
gi 320144554 402 AVI 404
Cdd:cd17475 373 AAL 375
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
50-382 |
1.38e-22 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 98.70 E-value: 1.38e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 50 LLASFFsLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYL--VRFLFGVGEAPMYPSNAVFNSFW 127
Cdd:cd17381 70 ILGSFF-YGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLiaVRALEGLGEGVTFPAMHAMWASW 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 128 FSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIAKDLpeqhrmvneaekrfimen 207
Cdd:cd17381 149 APPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLVMPL------------------ 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 208 rdivatekssppwndffkrfsfYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMS-ISSLPWLLMFFLILSAGAIS 286
Cdd:cd17381 211 ----------------------WAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGfLSALPYLGCWLFMILSGQIA 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 287 DRVlglgRSKFVARGV--------IAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGgiGISMGMSWAAATDLGRNFSG 358
Cdd:cd17381 269 DNL----REKQNFSTVcvrkiftlIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLG--GFSASGFNINHLDIAPSYAG 342
|
330 340
....*....|....*....|....
gi 320144554 359 TVSGWMNLWGNIGALISPLLAGLF 382
Cdd:cd17381 343 ILLGITNTFATIPGMVGPVIAKSL 366
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
17-387 |
1.52e-22 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 98.85 E-value: 1.52e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 17 FFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMI 96
Cdd:cd17328 5 FLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 97 KNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAF-NWQAVFYIFGAVG 175
Cdd:cd17328 85 PNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 176 ILMAVLWAIIakdLPEQHRMVNEAEKRFIMENRDIVATEKSSppwndfFKRFSFYAIAIQYFVVQFIITLFLIWLPTYLT 255
Cdd:cd17328 165 VLLAILLLLF---VREPPRGAAEGGVMAKSTATSFLADLKAL------AKNPSFILSTLGFTAVSFVTGALAFWAPTFFL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 256 EVFHVNFKEMSISSlpwlLMFFLILSAGAISDRVLGLGRSKFVARGVI---AIAGFIVFAVSIIFAVRTGNLYVSIFWLS 332
Cdd:cd17328 236 RAFGVGDLSSADVG----LIFGAITCIAGVLGVLLGGILADRLRRKTPradPLVCAVGLLAAAPFLFLALVLALSNLLLA 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320144554 333 LGLGGIGISMG-MSWAAATD------LGRNFSgTVSGWMNLWGN-IGALISPLLAGLFVEHLG 387
Cdd:cd17328 312 WVLLFLGEFLLsLNWAPVFAillyvvIPTRRS-TASAIQILLSHlLGDAGSPYLIGLISDLLR 373
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
10-407 |
3.66e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 97.23 E-value: 3.66e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 10 WMFALAFFFIGVIAYMdranISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAF 89
Cdd:cd17324 2 LALALAAFAIGTTEYV----IQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 90 TILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFY 169
Cdd:cd17324 78 NLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 170 IFGAVGILMAVLWAIIAKDLPEQHRMVNEAEKRFIMenrdivatekssppwndFFKRFSFYAIAIQYFVVQFIITLFLIW 249
Cdd:cd17324 158 AIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLL-----------------LLRNPRLRLAYLITFLLFGGFFALYTY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 250 LPTYLTEVFHvnfkeMSISSLPWLLMFFLILS------AGAISDRvlGLGRSKFVARGVIAIAGFIVFAVSIIFAVrtgn 323
Cdd:cd17324 221 LAPFLTDVPG-----FSSSAIIGLLLLFGVAGvvgsplAGRLADR--GGRRALLIALLLLAAALLLLTLLGPSPLL---- 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 324 LYVSIFWLSLGLGGIGISMgmsWAAATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAV 403
Cdd:cd17324 290 LLVGLVLWGLGFFAAHSAL---QTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLAL 366
|
....
gi 320144554 404 IMWF 407
Cdd:cd17324 367 LLAL 370
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
17-405 |
7.49e-22 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 96.12 E-value: 7.49e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 17 FFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMI 96
Cdd:cd17365 5 FLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 97 KNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGI 176
Cdd:cd17365 85 QSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 177 LMAVLWAIIAkdlpeqhrmvneaekrfimenrdivatekssppwndffkrfsfyAIAIQYFVVQFIITLFLIWLPTYLTE 256
Cdd:cd17365 165 ILLPLLRGTL--------------------------------------------LLWVTFFMGLLLVYLLNSWLPKLMVE 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 257 VfhvnfkEMSISSLPWLLMFFLIlsAGAISDRVLGLGRSKFVARGVIAIAGFIVFAVSIIFAVRTGN---LYVSIFwlSL 333
Cdd:cd17365 201 A------GYSLSQALTITLLLNI--GGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASlvlLYVLVF--LA 270
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320144554 334 GLGGIGISMGMSWAAATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVE-HLGWTMTFQLLIVPAVIAVIM 405
Cdd:cd17365 271 GACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAaGLGPESVFLALAIPAALGALA 343
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
2-405 |
2.57e-21 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 94.94 E-value: 2.57e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 2 KEKRTNVRWMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITI 81
Cdd:COG2807 9 RRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 82 ALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMypsNAVFNSF---WFSKNeKGRASSALLAGSYFGPVLAPIVTIAI 158
Cdd:COG2807 89 ALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVG---NVLLPGLikrWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 159 VNAFNWQAVFYIFGAVGILMAVLWAIIAKDLPEQHrmvneaekrfimenrdivATEKSSPPWNDFFKRFSFYAIAIQYFV 238
Cdd:COG2807 165 AAALGWRGALAVWALLALLALLLWLPLLRRRPAAA------------------AAAPAAASLRSLWRSPLAWLLTLFFGL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 239 VQFIITLFLIWLPTYLTEvfhvnfKEMSISSLPWLLMFFLI------LSAGAISDRVLGLgRSKFVARGVIAIAGFIVFA 312
Cdd:COG2807 227 QSLLYYAVVAWLPPILRD------AGLSAATAGLLLSLFQLagipgsLLVPLLADRLGDR-RPLLLLLGLLGLAGLLGLL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 313 VSIifavrTGNLYVSIFWLSLGLGGIgISMGMSWAAATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLG-WTMT 391
Cdd:COG2807 300 LAP-----GSLPWLWAVLLGLGQGGL-FPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGsWTAA 373
|
410
....*....|....
gi 320144554 392 FQLLIVPAVIAVIM 405
Cdd:COG2807 374 LLLLAALAVLMLVA 387
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
9-409 |
1.20e-20 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 93.08 E-value: 1.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 9 RWMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSA 88
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 89 FTILTG----MIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAF-- 162
Cdd:cd17345 81 INILIGfvpsATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFgd 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 163 -NWQAVFYIFGAVGILMAVLWAIIAKDLPEQ------HRMVNEAEKRFIMENRdivatEKSSPPWNDFFK-----RFSFY 230
Cdd:cd17345 161 gWWRGAFIFPAIIAIIVAVIVLFLGKDTPESeglppiEEYKGDYPEEADGEEE-----EQELSAWEIFVKyvlknKLLWY 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 231 AIAIQYFV--VQFIItlfLIWLPTYLTEVfhvnfKEMSISSLPWLLMFFLI------LSAGAISDRVLGlGRskfvaRGV 302
Cdd:cd17345 236 IAIANVFVylVRYGI---LDWAPTYLSEV-----KGFSKAQAMWAFSLFEWaaipgtLLAGWLSDKLFK-GR-----RAP 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 303 IAIAGFIVFAVSIIFAVRTGNLYV-SIFWLSLGLGGIGISMGMSWAAATDLGRNFSGTVSGWMNLWGNI-GALISPLLAG 380
Cdd:cd17345 302 TGIIFMILVIVALIVYWLAPNVLVdLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLgGSVLATALIG 381
|
410 420
....*....|....*....|....*....
gi 320144554 381 LFVEHLGWTMTFQLLIVPAVIAVIMWFYV 409
Cdd:cd17345 382 IIVDHFGWNGGFIVLLASCILAIIFLALV 410
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
15-409 |
1.33e-19 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 89.55 E-value: 1.33e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 15 AFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTG 94
Cdd:cd17474 3 AVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 95 MIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVnAFNWQAVFYIFGAV 174
Cdd:cd17474 83 LSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 175 GILMAVLWAIIAKDLPEQHRMVNEAEKRFIMEnrdivatekssppwndFFKRFSFYAIAIQYFVVQFIITLFLIWLPTYL 254
Cdd:cd17474 162 IPVAFLAILFLLPEPKEKAKSSSATKLRDLKK----------------ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 255 TEVFHVNfkEMSISslpwlLMFFLILSAGAISDRVLGLGRSKFVARGVIAIAGFIVFAVSIIFAVRTGNLYvsifWLSLG 334
Cdd:cd17474 226 ELLYGIS--PIIIG-----LLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLA----LLLIA 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 335 LGGIGISMGMSWAAATDLGRNFS-----GTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAVIMWFYV 409
Cdd:cd17474 295 IVLFGLGLGLNLPLLTTLVTELApeeerGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
9-407 |
2.35e-18 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 86.23 E-value: 2.35e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 9 RWMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSA 88
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 89 FTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVF 168
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 169 YIFGAVGILMAVLWAIIAKDLPEQHRMVNEAEKRfimENRDIVATEKSSPPWNDFFKRFSFYAIAIQYFVVQFIITLFLI 248
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEE---SKGKKKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 249 WLPTYLTEVFHVN--FKEMSISSLPwLLMFFLILSAGAISDRVLG--LGRSKFVARGVIAIAGFIVFAVSIIFAVRTGNL 324
Cdd:cd17343 238 WGQLFLIQDKGQSalTGSSFMSSLE-VGGFVGSIAAGYLSDWAVAkhGSSSRGNPRMPLALVFMAGLTVSLHLFRVHITS 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 325 YVSIFWLSLglggIGISMGMSW---------AAATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLL 395
Cdd:cd17343 317 DSSELFILL----LGFLIGFSLygpiaifgvIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRTAFLLL 392
|
410
....*....|..
gi 320144554 396 IVPAVIAVIMWF 407
Cdd:cd17343 393 EILCAITVVILF 404
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
44-394 |
3.72e-18 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 85.47 E-value: 3.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 44 TKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTIL--TGMIKNHGLIYLVRFLFGVGEAPMYPSNA 121
Cdd:cd17382 47 TPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLipIAARVHYGCVIFVRILQGLVEGVTYPACH 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 122 VFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIAKDLpeqhrmvneaek 201
Cdd:cd17382 127 GIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLVSMPV------------ 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 202 rfimenrdivatekssppwndffkrfsfYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSI-SSLPWLLMFFLIL 280
Cdd:cd17382 195 ----------------------------YAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGIlSALPHLVMTIIVP 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 281 SAGAISDRVLGLGR-SKFVARGVIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGGIGISMGMSWAAATDLGRNFSGT 359
Cdd:cd17382 247 IGGQLADYLRSRGIlSTTAVRKIFNCGGFGMEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASI 326
|
330 340 350
....*....|....*....|....*....|....*...
gi 320144554 360 VSGWMNLWGNIGALISPLLAGLFVEH---LGWTMTFQL 394
Cdd:cd17382 327 LMGISNGIGTLSGMVCPVIVGALTKHktrEEWQYVFLI 364
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
14-402 |
4.45e-18 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 85.15 E-value: 4.45e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 14 LAFFFIGVIA-YMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTIL 92
Cdd:cd17488 5 LASMFIGYAVfYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINIL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 93 TGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFG 172
Cdd:cd17488 85 FGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 173 AVGILMAvLWAIIakdlpeqhrmvneaekrfimenrdivaTEKSSPPWndffkrfsFYAIAIQYFVVQFIITLFLIWLPT 252
Cdd:cd17488 165 IIAILMG-IVLCW---------------------------RLRDRPPY--------IWLLAFCYVLVYVVRTAINDWGNL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 253 YLTEVFHVNF-KEMSISSLPWLLMFFLILSAGAISDRVLGLGRSKFvarGVIAIAGFIVFAVSIIFAVRTGNLYVSIFWL 331
Cdd:cd17488 209 YLSETHGYSLvKANSAVSLFEVGGLIGALVAGWGSDKLFKGNRGPM---NLIFALGLLVSVGALWLVPVHSYWLLATCFF 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320144554 332 SLGLGGIGISMGMSWAAATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIA 402
Cdd:cd17488 286 TIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAAAIS 356
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
5-410 |
1.76e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 83.75 E-value: 1.76e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 5 RTNVRWMFALAFFFIGVIAYMDRANISYIaKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALV 84
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLI-PALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 85 WWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMypsNAVFNSFwFSKNEKGRASSAL-LAGSYF--GPVLAPIVTIAIVNA 161
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLL---DVAANPY-VAALGPETAASRLnLLHAFFslGALLGPLLGGLLILL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 162 ---FNWQAVFYIFGAVGILMAVLWAIIAkdLPEqhrmvneaekrfIMENRDIVATEKSSPPWNDFFKRFSFYAIAI-QYF 237
Cdd:COG0738 158 glsLSWHLPYLILAVLLLLLALLFLRSK--LPE------------IEEEEEEAAGSAASLKSLLKNPRLLLGGLAIfLYV 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 238 VVQFIITLfliWLPTYLTEVFHVNFKEMSIsslpWLLMFFLILSAGaisdRVLGLGRSKFVARGVIAIAGFIVFAVSIIF 317
Cdd:COG0738 224 GAEGAIGD---WLPLYLKDVLGLSEATAAL----GLSLFWGGMTIG----RFLGGFLLKRFGPVRLLRLSALLAAVGLLL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 318 AVRTGNLYVSIfwLSLGLGGIGISMG--MSWAAATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLL 395
Cdd:COG0738 293 ALLAPGPWLAL--IGLALVGLGLSLMfpTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVP 370
|
410
....*....|....*
gi 320144554 396 IVPAVIAVIMWFYVK 410
Cdd:COG0738 371 LVCYLLILLLALALK 385
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
37-409 |
2.22e-17 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 83.09 E-value: 2.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 37 MMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPM 116
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 117 --YPSNAVFNSFWFSKNeKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAV-LWAIIAKDLPEQH 193
Cdd:cd17355 109 laAVAFATVAAWWFERR-RGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVpVLLLLRRRPADLA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 194 RmvneaekrfimENRDIVATEKSSPPWNDFFKRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSISSLPWL 273
Cdd:cd17355 188 L-----------RAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 274 LMFFLILSAGAISDRvlglgrskfVARGVIAIAGFIVFAVSIIfavrtgnLYVSIFWLSLGLGGIGISMGMSWAAATDL- 352
Cdd:cd17355 257 FNIVGRLLSGWLGDR---------YSPRRLLAASYALRALGLA-------LLLLLPFPPLALLLFAALFGLGWGATVPLt 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320144554 353 --------GRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLG-WTMTFQLLIVPAVIAVIMWFYV 409
Cdd:cd17355 321 aalaaryfGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALLVLPI 386
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
7-380 |
5.78e-17 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 82.02 E-value: 5.78e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 7 NVRWMFALAFFFIGV-IAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVW 85
Cdd:TIGR00895 12 SRYQWRAIILSFLIMlMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 86 WSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQ 165
Cdd:TIGR00895 92 FSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 166 AVFYIFGAVGILMAVLwaiIAKDLPE------------QHRMVNEAEKRFIMENRDIVATEKSSPP-WNDFFKR------ 226
Cdd:TIGR00895 172 SLFYVGGIAPLLLLLL---LMRFLPEsidflvskrpetVRRIVNAIAPQMQAEAQSALPEQKSTQGtKRSVFKAlfqgkt 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 227 -FSFYAIAIQYFVVQFIITLFLIWLPTYLTEvfhvnfkemSISSLPWLLMFFLILSAGAISDRVLGLGRSKFVARGVIA- 304
Cdd:TIGR00895 249 aRITVLLWLLYFMLLVGVYFLTNWLPKLMVE---------LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTAl 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 305 ---IAGFIVFAVSIIFAVRTGNLYVSI---FWLSLGLGGIGISMGMSWAAATdlgrnfSGTVSGWMNLWGNIGALISPLL 378
Cdd:TIGR00895 320 lllLGAVFAVLVGSTLFSPTLLLLLGAiagFFVNGGQSGLYALMALFYPTAI------RATGVGWAIGIGRLGAIIGPIL 393
|
..
gi 320144554 379 AG 380
Cdd:TIGR00895 394 AG 395
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
13-407 |
8.79e-17 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 81.11 E-value: 8.79e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 13 ALAFFFIGVIAYMDRANISYIAKQMM--DDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFT 90
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAaeFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 91 ILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAF----NWQA 166
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 167 VFYIFGAVGILMAVLWaiiakdlpeqhrmvneaeKRFIMenrdivatekssppwndffkrfsfyaIAIQYFVVQFIITLF 246
Cdd:cd17316 161 LFLIGALPALLALLLR------------------RRTLL--------------------------LILLWFFISFGYYGL 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 247 LIWLPTYLTEVFHVNFKEMSISSLPWLLMFFL-ILSAGAISDRVlglGRSKFvarGVIAIAGFIVFAVsIIFAVRTGNLY 325
Cdd:cd17316 197 TTFLPTYLQTVLGLSPATSSLYLLLISLGALVgALIAGLLSDRI---GRKKT---LVIGLILSGILAL-PLFYLLSGSPT 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 326 VSIFWLSLGLGGIGISMGMSWAAATDL-GRNFSGTVSGWMNLWGNIGALISPLLAGLFVE-HLGWTMTFQLLIVPAVIAV 403
Cdd:cd17316 270 LLLLLLFILSFFVGGVWGALYAYLAELfPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAsTGGTGVPALILALLAIVAL 349
|
....
gi 320144554 404 IMWF 407
Cdd:cd17316 350 IVAL 353
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
9-293 |
1.31e-16 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 79.86 E-value: 1.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 9 RWMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSA 88
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 89 FTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVF 168
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 169 YIfgavGILMAVLWAIIAKDLPEQHRMVNEAEKRFIMENRDIVATEKSSPPWNDFFKRFSFYAIAIQYFVVQFIITLFLI 248
Cdd:COG0477 172 LI----NAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLL 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 320144554 249 WLPTYLTEVFHVNFKEMSISSLPWLLMFFLILSAGAISDRVLGLG 293
Cdd:COG0477 248 LALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLA 292
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
31-407 |
2.21e-16 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 80.42 E-value: 2.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 31 SYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFG 110
Cdd:cd17371 19 GLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 111 VGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIV----NAFNWQAVFYifgaVGILMAVLWAIIA 186
Cdd:cd17371 99 LGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFpllpPEIAWRVLFL----LGALPALLVLFIR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 187 KDLPEQHRMVNEAEKRFIMENRDIVATEKsSPPWNDFFKRFSFYAIaiqyfVVQFIITLFLIWLPTYLTEVFHVNFKEMS 266
Cdd:cd17371 175 RFVKEPPQWQAARAARRHFADRPSLRELF-SPPLLRTTLLASLLAT-----GALGGYYGITTWLPSYLTGERGLSFEGSA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 267 I-SSLPWLLMFFLILSAGAISDRvlgLGRSKFVARGviAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGGIGISMG-- 343
Cdd:cd17371 249 GyLVVTILGGFLGYLAGGFLADR---IGRRNNFALF--ALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGay 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320144554 344 MSWAAATDLGrnfsGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLL-IVPAVIAVIMWF 407
Cdd:cd17371 324 LTELFPTAVR----ATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFaAVYYIAGLVLAL 384
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
37-404 |
7.15e-16 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 78.37 E-value: 7.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 37 MMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPM 116
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 117 YPSNAVFNSFwFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIAKDLPEqhrmv 196
Cdd:cd17478 102 HPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKP----- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 197 neaekrfimENRDIVATEKSSPPWNDFFKRFSFYAIAIqyFVVQFIITLFLIWLPTYLTEVFhvnfkeMSISSLPWLLMF 276
Cdd:cd17478 176 ---------EAKKAAAKSSARSTLKGVWRALLLLLIIV--FLRSWVLSSLTTFLPFYLVQRG------YSLVFAGLLLSL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 277 FLILSA------GAISDRvlgLGRskfvaRGVIAIAGFIVFAVSIIFavrtgnLYVSIFWLSLGLGGIGISMGMSWAA-- 348
Cdd:cd17478 239 FLFAGAigtligGPLSDR---FGR-----RRVIIASLLLAAPFLLLF------LLTPGIWSYILLVLAGFLLFASFPVtv 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 320144554 349 --ATDLGRNFSGTVSGWMNLWGN-IGALISPLLaGLFVEHLGWTMTFQLLIVPAVIAVI 404
Cdd:cd17478 305 vlAQELLPGNVGLASGLMMGLSFgLGGIGAPVL-GALADAFGLESVLLILALLPLLGAL 362
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
17-408 |
2.24e-15 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 77.29 E-value: 2.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 17 FFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGM- 95
Cdd:cd17341 5 WLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALa 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 96 IKNHGLIYLVRFLFGVGEApMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNA-------FNWQAVF 168
Cdd:cd17341 85 VSSYWGLLVLGFLLGFAGA-NFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAivfdggfVGWRNAF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 169 YIFGAVGILMAVLWAIIAKDLPEQhrmvneaekrfimenrdIVATEKSSPPWNDFFKRFSFYAIAIQYFVVQFIITLFLI 248
Cdd:cd17341 164 FVPGILLAIAAVLVLLFGDDLPTG-----------------KASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSN 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 249 WLPTYLTEVFHVNFKEMSISSLPWLLMFFLILSA-GAISDRVLGLGRSKFVargviaiagFIVFAVSIIFAVRTGNLYVS 327
Cdd:cd17341 227 VLPTYFKTRFGLPLVTAGILAALFPLAGALARPAgGWLSDRFGGRRRLWWL---------FIVMTIGAALLSLSLPTSGT 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 328 IFWLSLGLG-----GIGISMGMSWAAATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIA 402
Cdd:cd17341 298 NLVLFLALFvalglGAGAGNGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVA 377
|
....*.
gi 320144554 403 VIMWFY 408
Cdd:cd17341 378 CTLLVW 383
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
37-383 |
6.80e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 75.67 E-value: 6.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 37 MMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPM 116
Cdd:cd17321 22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 117 YPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLwaiiakdlpeqhrmv 196
Cdd:cd17321 102 MPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL--------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 197 neaekrfimenrdivatekssppwndfFKRFSFYAIAIqyFVVQFIITLFLIWLPTYLTEVFHVNFKEMSISSLPW-LLM 275
Cdd:cd17321 167 ---------------------------ARTFSGAVLAA--FLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLaLAM 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 276 FFLILSAGAISDRvlglgrskFVARGVIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGGIGisMGMSWAAATD---- 351
Cdd:cd17321 218 LVAAPLAGRLADR--------FGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLG--LGLFATPLTNaals 287
|
330 340 350
....*....|....*....|....*....|...
gi 320144554 352 -LGRNFSGTVSGWMNLWGNIGALISPLLAGLFV 383
Cdd:cd17321 288 sVPKEKAGAASGILNTARQLGGALGVALLGALL 320
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
18-408 |
7.52e-15 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 75.69 E-value: 7.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 18 FIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIK 97
Cdd:cd17323 6 FLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 98 NHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFgavGIL 177
Cdd:cd17323 86 NIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL---AII 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 178 MAVLWAIIAKDLPeqhrmvneaekrfimenrdIVATekssppwndffkrFSFYaIAIQYfvvqFIITLFLIWLPTYLTEV 257
Cdd:cd17323 163 SGFCLILIFLFLP-------------------IVLL-------------LGLY-VGLVY----AILYLFLTAFPYVFGEV 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 258 FHVNFKEMSISSLPWLL-MFFLILSAGAISDRVL------GLGRSKFVARGVIAIAGFIVFAVSI-IFAVRTgnlYVSIF 329
Cdd:cd17323 206 YGFSPGEVGLMYLPIGIgALIGSIIGGRLSDYYYrrlkkkNGGKPEPEARLPPAFIGAFLFPIGLfIFGWTI---YPHIH 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 330 WLS--LGLGGIGISMGMSWAAA----TDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLG--WTMTFQLLIVPAVI 401
Cdd:cd17323 283 WIVpiIGSAFFGFGLMLIFQSSltylVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLGvgWAFTLLAFISLAMI 362
|
....*..
gi 320144554 402 AVIMWFY 408
Cdd:cd17323 363 PIPFIFY 369
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
36-388 |
4.67e-13 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 70.30 E-value: 4.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 36 QMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAP 115
Cdd:cd17503 21 TIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 116 MYPS--NAVFNSFwfSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIakDLpeqh 193
Cdd:cd17503 101 LIPLaqTILLRIY--PPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLL--DL---- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 194 rmvneaekrfimenrdivatekssppwnDFFKRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSISSLPW- 272
Cdd:cd17503 173 ----------------------------RLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGg 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 273 LLMFFLILSAGAISDrvlglgrsKFVARGVIaIAGFIVFAVS-IIFAVRTGNLYVSIFWLSLGLGGIGISMGMS---WAA 348
Cdd:cd17503 225 LASAILSPLVGRLLD--------KFGPRLLL-LAGLLLLALGtLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMplnTLA 295
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 320144554 349 ATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGW 388
Cdd:cd17503 296 LNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQ 335
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
24-414 |
6.91e-13 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 69.74 E-value: 6.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 24 YMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIY 103
Cdd:PRK11663 36 YFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSSSLWAFA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 104 LVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWA 183
Cdd:PRK11663 116 LLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHYGWRYGMMIAGIIAIVVGLFLC 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 184 IIAKDLPEQHRMVNEAEKRF-IMEnrdiVATEKSSP--PWNDFFKRFSF-----YAIAIQYFVVQFIITLFLIWLPTYLT 255
Cdd:PRK11663 196 WRLRDKPQAMGLPSVGEWRHdALE----LAQQQEGAglSRKEILTKYVLlnpyiWLLSFSYVLVYVVRAAINDWGNLYMS 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 256 EVFHVNFkemsISSLPWLLMFFLilsAGAISDRVLGLGRSKFVA--RGVIAiagfIVFAVSIIFAVrtGNLYVSIF---- 329
Cdd:PRK11663 272 ETLGVDL----VTANSAVSMFEL---GGFIGALVAGWGSDKLFNgnRGPMN----LIFAAGILLSV--GSLWLMPFasyv 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 330 -----WLSLGLGGIGISMGMSWAAATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLL-IVPAVIAV 403
Cdd:PRK11663 339 mqaacFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGYPLAKVLEIWHWTGFFVVIsIAAGISAL 418
|
410
....*....|.
gi 320144554 404 IMWFYVKPDQP 414
Cdd:PRK11663 419 LLLPFLNAQAP 429
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
49-407 |
2.40e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 67.98 E-value: 2.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 49 GLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWF 128
Cdd:cd17473 38 PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYF 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 129 SKNEKGRASSALLAGSYFGPVLAPIVTIAIVnAFNWQAVFYIFGAVGILMAVLWAiiakdlpeqhrMVNEAEKRFIMENR 208
Cdd:cd17473 118 EGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLALPVLILVLL-----------FLPEPARKSKSAAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 209 DIVATEKSSPPwndffkrFSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKE----MSISSLpwllmfflilsAGA 284
Cdd:cd17473 186 PGAATAAALPW-------KRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALiglaLAIASL-----------AGA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 285 ISDRVLGLGRSKFVARGVIAIaGFIVFAVSIIFAVRTGNLYVSIfwLSLGLGGIGISM----GMSWAAAtDLGRNFSGTV 360
Cdd:cd17473 248 IGALLFGRLKRRLGKRRLLAI-GFALMALGFLLLALASGLWVVL--LGAILAGLGFGLllptLNSWAMS-LVPPELRGRA 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 320144554 361 SGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLL--IVPAVIAVIMWF 407
Cdd:cd17473 324 MGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLIlgVLALVLAIVLLL 372
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
46-407 |
3.80e-12 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 67.35 E-value: 3.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 46 PQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMypsNAVFNS 125
Cdd:cd17333 31 ADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGIL---DTGANT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 126 FWFSKNEKGRASSALLAGSYFGP---VLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIAKDLPEQHRMVNEAEKR 202
Cdd:cd17333 108 FVGALFEESSATRLNVLHGFFGLgalIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 203 FimenrdivateksSPPWNDFFKRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSIS-SLPWLLMFFLILS 281
Cdd:cd17333 188 F-------------SASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLlSGFWVGITIGRLL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 282 AGAISDRVlgLGRSKFVARGVIAIAGFIVFAVSIIFAVrtgnLYVSIFWLSLGLGG---IGISMGMSWAAATdlgrnfSG 358
Cdd:cd17333 255 GGPISRRI--KPHTLLVLSGSGALLGLLILLLAPTLVV----GLVATALLGLFMAAlfpTILSLGISNLPYA------KG 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 320144554 359 TVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAVIMWF 407
Cdd:cd17333 323 KGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLAL 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
37-186 |
4.11e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 67.22 E-value: 4.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 37 MMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPM 116
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 117 YPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIA 186
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
9-405 |
4.99e-12 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 66.86 E-value: 4.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 9 RWMFALAFF---FIGVIAYmdraNISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVW 85
Cdd:cd17353 2 RWLVLLGAVlmhLILGYQY----AWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 86 WSAFTILTGMIKNHGLIYLVR-FLFGVGEAPMYP---SNAVfnsFWFSKNeKGRASSALLAGSYFGPVLAPIVTIAIVNA 161
Cdd:cd17353 78 FGLGFILSAFAISLPLLFLGYgVLGGIGAGIGYItpvSTAV---KWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 162 FNWQAVFYIFGAVGILMAVLWAIIAKDLPEQHRMVNEAEKRFIMENRDIVATekssppWNDFFKRFSFYAIAIQYFVVQF 241
Cdd:cd17353 154 VGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYT------PREMLRTPTFWLLWLMFFLNAT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 242 IITLFLIWLPTYLTEVFHVNFKEMSIS-SLPWLLMFFLILSAGAISDRvlgLGRSKfvargvIAIAGFIVFAVSIIFAVR 320
Cdd:cd17353 228 AGLMLIGQAKPIGQEFAGLDAGIAALAvSILSIFNGGGRPFWGWLSDK---IGRKN------TLSIAFLIQGVAMFLLPF 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 321 TGNLYVS-IFWLSLGLGGIGISMGMSWAAATDL-GRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVP 398
Cdd:cd17353 299 IGSVAVLfVLGVALIGFCYGGGFALFPALTADFfGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAAL 378
|
....*..
gi 320144554 399 AVIAVIM 405
Cdd:cd17353 379 SLVALAL 385
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
40-409 |
6.40e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 63.38 E-value: 6.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 40 DLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPS 119
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 120 NAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIAKDLPEQHrmvnea 199
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAA------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 200 ekrfimenrdiVATEKSSPPWNDFFKRfSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKemsisslpwllMFFLI 279
Cdd:cd17489 179 -----------EEAEAGTRAFRRLVEK-KVLPPALILFLASIAYGAISTFLPLYAAERGISNAG-----------LFFTV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 280 LSAGAISDRVLGLGRSKFVARGVIAIAGFIVFAVSI-IFAVRTGNLYVSIFWLSLGLG-GIGISMGMSWAAATdLGRNFS 357
Cdd:cd17489 236 YAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLlLLSFAGSPWMLLLAAVLYGLGfGLLFPALQALAVDL-VPPHRR 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 320144554 358 GTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQL-LIVPAVIAVIMWFYV 409
Cdd:cd17489 315 GAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLaAVVVLLALVLYIFLL 367
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
34-380 |
7.47e-10 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 60.36 E-value: 7.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 34 AKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGE 113
Cdd:PRK11551 38 APRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 114 APMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLwaiIAKDLPEQH 193
Cdd:PRK11551 118 GGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPL---LMRWLPESR 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 194 RMVNEAekrfimenrdiVATEKSSPPWNDFF---KRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEvfhvnfKEMSISSL 270
Cdd:PRK11551 195 AFAQAA-----------GAGKQRAPVLRALFgegRATATLLLWISYFFTLIVLYFLLNWLPSLLVG------QGLSRSQA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 271 PWLLMFFLIlsAGAISDRVLGLGRSKFVARGVIAiagfIVFAvSIIFAVRTGNLYVSIFWLSLG--LGGIGISMGMS--W 346
Cdd:PRK11551 258 GLVQIAFNI--GGALGSLLIGALMDRLRPRRVVL----LIYA-GILASLAALAAAPSFAGMLLAgfAAGLFVVGGQSvlY 330
|
330 340 350
....*....|....*....|....*....|....*
gi 320144554 347 A-AATDLGRNFSGTVSGWMNLWGNIGALISPLLAG 380
Cdd:PRK11551 331 AlAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAG 365
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
36-409 |
7.76e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 60.28 E-value: 7.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 36 QMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVG-EA 114
Cdd:cd17320 24 AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGaAA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 115 PMYPSNAVFNSFwFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVL-WAIIAKDLPEQH 193
Cdd:cd17320 104 GSVVARAIVRDL-YSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLvLLFLPETLPEEK 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 194 RMVneAEKRFIMENRDIVATekssppwndffKRFSFYAiaiqyFVVQFIITLFLIWL---PTYLTEVFHVNfkeMSISSL 270
Cdd:cd17320 183 RKP--LLSSLLRAYKRVLKN-----------RRFLGYA-----LALGLSFAGLFAYLaaaPFIYIEQLGLS---PAQFGL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 271 PWLLMFFLILSAGAISDRVLGLGRSKFVARGVIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGGIGISMGMSWAAAT 350
Cdd:cd17320 242 LFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLAL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 320144554 351 DLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVpAVIAVIMWFYV 409
Cdd:cd17320 322 EPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVL-GLLALLLLILL 379
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
10-191 |
8.41e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 59.88 E-value: 8.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 10 WMFALAFFFIGVIAYmdrANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSA- 88
Cdd:COG2271 183 WLLALAYFLVYFALY---GFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAa 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 89 -FTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAV 167
Cdd:COG2271 260 lALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|....
gi 320144554 168 FYIFGAVGILMAVLWAIIAKDLPE 191
Cdd:COG2271 340 FLLLAALALLAALLALLLLRETRK 363
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
131-408 |
1.96e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.15 E-value: 1.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 131 NEKGRASSALLAGSYFGPVLAPIVTIAIVNAF------NWQAVFYIFGAVGILMAVLWAIIAKDlpeqhRMVNEAEKRFI 204
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKE-----RPVPEEEKVSL 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 205 MENrdivatekssppWNDFFKRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSISSLPWLLMFFL-ILSAG 283
Cdd:COG2211 218 KES------------LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLgAPLWP 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 284 AISDRvlgLGRSKfvargvIAIAGFIVFAVS--IIFAVRTGNLYVSIFWLSLGLGGIGISMGMSWAAATDL--------G 353
Cdd:COG2211 286 RLAKR---FGKKK------AFIIGLLLAALGllLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydewktG 356
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320144554 354 RNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLG------------WTMTFQLLIVPAVI----AVIMWFY 408
Cdd:COG2211 357 RRREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspsalTGIRLLFFLLPAVLlllaALLLLFY 427
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
30-191 |
2.50e-09 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 58.79 E-value: 2.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 30 ISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLF 109
Cdd:PRK12307 37 IFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 110 GVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIfgavGILMAVLWAIIAKDL 189
Cdd:PRK12307 117 GMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFV----GLLPVLLVIYIRARA 192
|
..
gi 320144554 190 PE 191
Cdd:PRK12307 193 PE 194
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
4-185 |
3.14e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 58.40 E-value: 3.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 4 KRTNVRWMFALAFFFIGVIAYMDRANISYIAKqmmDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIAL 83
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAK---EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 84 VWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFN 163
Cdd:cd06173 282 LLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALG 361
|
170 180
....*....|....*....|..
gi 320144554 164 WQAVFYIFGAVGILMAVLWAII 185
Cdd:cd06173 362 LSAVFLLAGALLLLAALLLLLL 383
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
37-409 |
1.77e-08 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 55.85 E-value: 1.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 37 MMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVG-EAP 115
Cdd:TIGR00710 31 IAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGaSAG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 116 MYPSNAVFNSFwFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAvlwAIIAKDLPEQHRM 195
Cdd:TIGR00710 111 SVISQALVRDI-YPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLS---ALIFFILPETLPY 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 196 VNEAEKRFIMENRDIvateksspPWNDffKRFSFYAIAIQYFVVQFIItlFLIWLPTYLTEVFHVNFKEMSISslpWLLM 275
Cdd:TIGR00710 187 EARIQISTYFETFLL--------LLKS--KMFWGYALIYGASFGGFFA--FFSGAPFVYIDIMGVSPSVFGLL---FALN 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 276 FFLILSAGAISDRVLGLGRSKFVARgvIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGGIGISMGMSWAAATDLGR- 354
Cdd:TIGR00710 252 IIAMIFGGFLNGRFIKKWGAKSLLR--MGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYALEDf 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 320144554 355 -NFSGTVSGWMN-LWGNIGALISPLLaGLFVEHLGWTMTFQLLiVPAVIAVIMWFYV 409
Cdd:TIGR00710 330 pHVAGTASALFGtLRLVLGAIVGYLV-SLIHGNTAWPMSLSCL-VLAVVSVLAFYYL 384
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
40-195 |
2.90e-08 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 55.31 E-value: 2.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 40 DLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGV-GEAPMYP 118
Cdd:PRK11102 20 DFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLaAAAASVV 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320144554 119 SNAVFNSFwFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVL-WAIIAKDLPEQHRM 195
Cdd:PRK11102 100 INALMRDM-FPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALvFFFIPETLPKERRQ 176
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
9-382 |
5.22e-08 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 54.73 E-value: 5.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 9 RWMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSA 88
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 89 FTILTGMIKNHGLIYLVRFLF-GVGEAPMYPSNAVFNSFWFSkNEKGRASSALLAGSYFGPVL-APIVTIAIVNAFnWQA 166
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFiGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLgSPLLRILWVFYG-LAL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 167 VFYIfgaVGILMAVLWAIIAKDLPeQHRMVNEAEKRfimenrdivATEKSSPPWNDFFKRFSFYAIAIQYFVVQFIITLF 246
Cdd:cd17314 159 VYTI---LGILAAIVLSVVSLLGF-KEPPDNQARLH---------VQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLF 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 247 LIWLPTY--LTEVFHVNFKEMSISSLPwLLMFFLILSAGAISDRVLGLGRSKFVargVIAIAGFIVFAvsIIFAVRTGNL 324
Cdd:cd17314 226 IANMASLvrSLQLDAPSFVTKLMSIYG-LFNAFGRLLWGIVADFFGGRLSTLSI---LLTILGLGLCA--FLFLLKMTPV 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 320144554 325 YVSIFWLSLGLGGIGISMGMSWAAATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLF 382
Cdd:cd17314 300 GLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKF 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
232-412 |
5.52e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 54.35 E-value: 5.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 232 IAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMS-ISSLPWLLMFFLILSAGAISDRvlgLGRSKFVargVIAIAGFIV 310
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGlLLTLFSLGYALAQPLAGRLSDR---FGRRRVL---LIGLLLFAL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 311 FAVSIIFAVRTGNLYVSIFWLSLGLGGIGISMGMSWAAATDLGRnfSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTM 390
Cdd:pfam07690 75 GLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEE--RGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA 152
|
170 180
....*....|....*....|..
gi 320144554 391 TFQLLIVPAVIAVIMWFYVKPD 412
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPRPP 174
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
57-188 |
6.10e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 51.50 E-value: 6.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 57 LGYALMQV----PSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNE 132
Cdd:TIGR00880 5 AGYALGQLiyspLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 320144554 133 KGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIAKD 188
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
224-414 |
2.31e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 52.28 E-value: 2.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 224 FKRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEvFHVNFKEMS-ISSLPWLLMFFLILSAGAISDRvlgLGRSKFVargV 302
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGlVVTAYLLGAALGAPLAGRLADR---FGRRRVL---L 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 303 IAIAGFIVFAVSIIFAVrtgnlyvSIFWLSLGLGGIGISMGMSWAAATDLGRNFS-----GTVSGWMNLWGNIGALISPL 377
Cdd:COG2814 80 LGLLLFALGSLLCALAP-------SLWLLLAARFLQGLGAGALFPAALALIADLVpperrGRALGLLGAGLGLGPALGPL 152
|
170 180 190
....*....|....*....|....*....|....*...
gi 320144554 378 LAGLFVEHLGWTMTFQLLIVPAVIA-VIMWFYVKPDQP 414
Cdd:COG2814 153 LGGLLADLFGWRWVFLVNAVLALLAlLLLLRLLPESRP 190
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
38-409 |
2.86e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 52.18 E-value: 2.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 38 MDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMY 117
Cdd:cd17477 23 LEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 118 PSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVtIAIVNAFNWQAvfYIFGAVGILMAVLWAIIAKDLPeqhrmvn 197
Cdd:cd17477 103 VVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGALP--FLIAAVLLLLALVPLLLTRRAA------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 198 eaekrfimenrdIVATEKSSPPWNDFFKRFSFYAIAIqyFVVQFIITLFLIWLPTYLTEVfhvnfkEMSISSLPWLLMFF 277
Cdd:cd17477 173 ------------PEIEEAESISLRRLLRIAPLALLGA--FVAGFLEGAFYSLLPLYGLRL------GLSVAQAALLLAAF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 278 LILSA------GAISDRVlglGRskfvaRGVIAIAGFIVFAVSIIFAVrTGNLYVSIFWLSLGLGGIGISM---GMSWAA 348
Cdd:cd17477 233 VLGGLllqwplGWLADRF---DR-----RRVLLGCALLGALAALLLPL-VPGLPLALLVLLFLWGGAAGPLytlALALAG 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320144554 349 AtDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGwtmTFQLLIVPAVIAVIMWFYV 409
Cdd:cd17477 304 D-RLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFG---PHGLFLFLAAVALLFLLFL 360
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
9-409 |
4.87e-07 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 51.63 E-value: 4.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 9 RWMFALAFFFIGVIAYMDRANISyIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSA 88
Cdd:PRK11273 27 RWQIFLGIFFGYAAYYLVRKNFA-LAMPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 89 FTILTGMI----KNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFN- 163
Cdd:PRK11273 106 VMLFMGFVpwatSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLFLLGMAWFNd 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 164 WQAVFYIFGAVGILMAVLWAIIAKDLPEQHRMVN-EAEKRFIMENRDIVATEKSSPpwNDFFKRFSF-----YAIAIQYF 237
Cdd:PRK11273 186 WHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPiEEYKNDYPDDYNEKHEQELTA--KQIFMQYVLpnkllWYIAIANV 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 238 VVQFIITLFLIWLPTYLTEVFHVNFKEMSisslpWLLMFFL------ILSAGAISDRVLGLGRSkfvARGVIAIAgFIVF 311
Cdd:PRK11273 264 FVYLLRYGILDWSPTYLKEVKHFALDKSS-----WAYFLYEyagipgTLLCGWMSDKVFRGNRG---ATGVFFMT-LVTI 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 312 AVSIIFAVRTGNLYVSIFWL-SLGLGGIGISMGMSWAAATDLGRNFSGTVSGWMNLWGNI-GALISPLLAGLFVEHLGWT 389
Cdd:PRK11273 335 ATIVYWLNPAGNPTVDMACMiVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLgGSVAASAIVGYTVDFFGWD 414
|
410 420
....*....|....*....|
gi 320144554 390 MTFQLLIVPAVIAVIMWFYV 409
Cdd:PRK11273 415 GGFMVMIGGSILAVILLIVV 434
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
61-410 |
8.07e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 50.68 E-value: 8.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 61 LMQVPSGMLAEKFGPRKMITIALVWWSAF-TILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFwFSKNEKGRASSA 139
Cdd:cd17490 46 LLRIPLGILSDRIGKRKLFIIIGLLFTVLaSLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASY-FPPDEAAKAMGL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 140 LLAGSYFGPVLAPIVTIAIVNAFNWQAVFYifgaVGILMAVLWAIIAKDLPEQhrmvNEAEKRFIMENRDIVATEKsspp 219
Cdd:cd17490 125 INLVNNLGQLIAFLIGGLIAEHFGMRAPFL----LAALAGVLGFILSLFIKEE----RREKKPVLTELKELLSVLK---- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 220 wNDFFKRFSFYAIAIQYfvVQFIITLFLIwlPTYLTEVFhvnfkeMSISSLPWLLMFFLIlsAGAISDRVLGLGRSKFVA 299
Cdd:cd17490 193 -DKKLLFFSLLAILQQM--ITFSTTFGFT--PLIAKQLG------ASSFQLGLLSIIYLL--PNALASLLSGTLFYKKLG 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 300 RGVIAIAGFIVFAVSIIFAVRTGNLYVsiFWLSLGLGGIGISMGMSW---AAATDLGRNFSGTVSGWMNLWGNIGALISP 376
Cdd:cd17490 260 ERNTIIIGFLLLGAYCFLIPFAPNLTL--LYLLQALNGFGTGILFPLlmsLSIEGVPAEQRSTAMGFFQAIYALGMFLGP 337
|
330 340 350
....*....|....*....|....*....|....
gi 320144554 377 LLAGLFVEHLGWTMTFQLLIVPAVIAVIMWFYVK 410
Cdd:cd17490 338 VLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
267-414 |
8.73e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 50.64 E-value: 8.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 267 ISSLPWLLMFFLILSAGAISDRvLGLGRSKFVARGVIAIAgfivfavsiiFAVRTGNLYVSIFWLSLGLGGIGISMG--- 343
Cdd:COG2807 58 LTTLPLLAFGLFAPLAPRLARR-FGLERTLLLALLLLAAG----------LLLRSLAPSVALLLAGTALIGAGIAVGnvl 126
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320144554 344 MSWAAATDLGRNfSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAVIMWFYVKPDQP 414
Cdd:COG2807 127 LPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRP 196
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
67-193 |
9.15e-07 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 50.85 E-value: 9.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 67 GMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYF 146
Cdd:PRK03893 76 GAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSI 155
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 320144554 147 GPVLAPIVTIAIVNAFNWQAVFYIfGAVGILMAvLWaiIAKDLPEQH 193
Cdd:PRK03893 156 GAVVAAQVYSLVVPVWGWRALFFI-GILPIIFA-LW--LRKNLPEAE 198
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
36-202 |
1.06e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 50.38 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 36 QMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAP 115
Cdd:cd06180 24 LMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAF 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 116 MYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVL-APIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIAKDLPEQHR 194
Cdd:cd06180 104 VFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALsGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPT 183
|
....*...
gi 320144554 195 MVNEAEKR 202
Cdd:cd06180 184 EASAAESA 191
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
48-407 |
1.55e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.92 E-value: 1.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 48 FGLLASFFSLGYALMQVPSGMLAEKFGPRKMItIALVWWSAFTILTGMIKNHG------LIYLVRFLFGVGEAPMYP-SN 120
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLL-ILADLLRALLAAVLALLALLgslslwLLLVLAFLLGIASAFFGPaRQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 121 AVFNSFwFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIAKDLPEQHRMVNEAE 200
Cdd:cd06173 115 ALLPEL-VPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 201 KRFIMENRDIvatekssppwndFFKRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSIsslpwllmFFLIL 280
Cdd:cd06173 194 LRDLREGLRY------------LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGL--------LLAAF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 281 SAGAISDRVLGLGRSKFVARGVIAIAGFIVFAVSIIFAVRTGNLYVS-IFWLSLGLGGIGISMGMSWAAATDLGRNFSGT 359
Cdd:cd06173 254 GVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLlAALFLLGLAGGLFNVPLNTLLQLRVPDELRGR 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 320144554 360 VSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAVIMWF 407
Cdd:cd06173 334 VFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLL 381
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
41-407 |
1.63e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 49.85 E-value: 1.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 41 LGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFT-ILTGMIKNHGLIYLVRFLFGVGEAPMYPS 119
Cdd:cd17370 29 LGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLSALAkPLLALAGSWQLVLLLRILERLGKGIRTPP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 120 NAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIV--NAFNWQAVFYIFGAVGILMAVLWAIIAKDLPEQHRMvn 197
Cdd:cd17370 109 RDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLylLGGNYRTIFLLAAIPALLALLILLFVVKEYPRPPKL-- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 198 eaekrfimenrdivATEKSSPPWNDFFKRFsfyaiaIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSISSLPWLLMFF 277
Cdd:cd17370 187 --------------RKKSKKTSLKKLPKAF------WLYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 278 LILSA---GAISDRVLglgrskfvaRGVIAIAGFIVFAVSIIFAVRTGNLYVsiFWLSLGLGGIGISM---GMSWAAATD 351
Cdd:cd17370 247 YALAAypaGRLSDRIG---------RKKLLILGYLSLALAYLGFALGSSLWL--LLLGFILWGLYMGAqesIERAAVADL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 320144554 352 LGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAVIMWF 407
Cdd:cd17370 316 VPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
10-187 |
2.87e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.08 E-value: 2.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 10 WMFALAFFFIGVIAYmdrANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAF 89
Cdd:COG0738 213 LLGGLAIFLYVGAEG---AIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 90 TILTGMIKNHGLIYLVRFLFGVGEAPMYPS--NAVFNSFwfsKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAV 167
Cdd:COG0738 290 LLLALLAPGPWLALIGLALVGLGLSLMFPTifSLALDGL---GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAA 366
|
170 180
....*....|....*....|
gi 320144554 168 FYIFGAVGILMAVLWAIIAK 187
Cdd:COG0738 367 FLVPLVCYLLILLLALALKR 386
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
223-411 |
9.82e-06 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 47.57 E-value: 9.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 223 FFKRFSFYAiaiqyfvVQFIITLFLIwlptylTEVFHVNFKE--MSISSLPWLLMFFLILSAGAISDRVLGLGRSKFVAr 300
Cdd:cd17346 12 MWERFSYYG-------MRAILILYLT------AQLGDGFSEAdaASIYGAYTALVYLTPIIGGWLADKVLGARRTVFIG- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 301 GVIAIAGFIVFAVSiifavrtgNLYVSIFWLSLGLGGIGISMgMSWAAATDLGRNFSGTV----SGW--MNLWGNIGALI 374
Cdd:cd17346 78 GILMALGYLLLALS--------PFSVSMLYLGLALIIVGNGL-FKPNISSLVGKLYDENDprrdSGFsiFYMGINLGAFL 148
|
170 180 190
....*....|....*....|....*....|....*..
gi 320144554 375 SPLLAGLFVEHLGWTMTFQLLIVPAVIAVIMWFYVKP 411
Cdd:cd17346 149 APLLCGTLGDNYGYHYGFGLAAVGMLLGLLIFLLGRK 185
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
225-410 |
1.20e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 46.73 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 225 KRFSFYAIAIQYFVVQFIITLFLIWLPTyLTEVFHVNFKEMS-ISSLPWLLMFFLILSAGAISDRvlgLGRSKFVargVI 303
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGwIVSAYLLGRAIGLLLFGRLGDR---YGRKRVL---LI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 304 AIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGGIgisMGMSWAAATDL-GRNFSGTVSGWMNLWGNIGALISPLLAGLF 382
Cdd:COG0477 85 GLLLFGLASLLCGLAPSPELLIAARALQGIGAGGL---MPGALALIAELfPARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180
....*....|....*....|....*...
gi 320144554 383 VEHLGWTMTFQLLIVPAVIAVIMWFYVK 410
Cdd:COG0477 162 VAALGWRWIFLINAPLGLLALVLRLRLP 189
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
10-407 |
1.22e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 47.16 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 10 WMFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAF 89
Cdd:cd17352 2 WVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 90 TILTGMIKNHGLIYL-VRFLFGVGEAPMYPSNAVFNSFWFSKNeKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVF 168
Cdd:cd17352 82 LLLSSFATSLWQLYLtYGVLGGLGLGLIYSPAIVIVGQYFEKK-RGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 169 YIFGAVGILMAVLWAIIAkdlpeqhrmvneaekrfimenrdivatekssppwndFFKRFSFYAIAIQYFVVQFIITLFLI 248
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR------------------------------------LLKDPTFVLLALGVSFAMLGFFVPFV 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 249 WLPTYLTEVFHVNFKEMSISSLPWLLMFFLILSAGAISDRvlglgrsKFVARGVIAIAGFIVFAVSIIFAVRTGNLYVSI 328
Cdd:cd17352 205 YLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADK-------PRIGRLYLYIFTLLILGLSLLAFPLATTYVGLI 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 329 FWLSLglggIGISMGMSWA-----AATDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLG-WTMTFQLLIVPAVIA 402
Cdd:cd17352 278 VFSVL----FGFCSGSYSSltpviLADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGdYDAAFYFCGACLLLS 353
|
....*
gi 320144554 403 VIMWF 407
Cdd:cd17352 354 GVLLF 358
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
10-203 |
1.23e-05 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 46.91 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 10 WMFALAFFFIGVIAYMDRANISYIAKqmmDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAF 89
Cdd:TIGR00886 4 FFSWFGFFLSFLVWFAFSPLAVFLIK---DDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 90 TILTGMI-KNHGLIYLVRFLFGVGEApMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAF------ 162
Cdd:TIGR00886 81 CLWAGLAvQSYSVLLLIRLFIGIAGG-SFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLifgggq 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 320144554 163 ----NWQAVFY-----IFGAVGILMAVLWA-IIAKDLPEQHRMVNEAEKRF 203
Cdd:TIGR00886 160 pahlAWGWAFVivpagILLLPALLIFFVGAdTPPGKPATGKLSFKEALKVF 210
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
10-182 |
2.49e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 46.16 E-value: 2.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 10 WMFALAFFFIGVIAYmdrANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSA- 88
Cdd:cd17333 202 ILGALALFLYVGAET---AFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLg 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 89 FTILTGMIKNHGLIYLVrFLFGVGEAPMYPS-NAVFNSFWfsKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAV 167
Cdd:cd17333 279 LLILLLAPTLVVGLVAT-ALLGLFMAALFPTiLSLGISNL--PYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTA 355
|
170
....*....|....*
gi 320144554 168 FYIFGAVGILMAVLW 182
Cdd:cd17333 356 MLLITILYAIIFVLA 370
|
|
| yjdL_sub1_fam |
TIGR00924 |
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ... |
274-407 |
2.62e-05 |
|
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273342 [Multi-domain] Cd Length: 475 Bit Score: 46.37 E-value: 2.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 274 LMFFLILSAGAISDRVLGLGRSKFVARGVIAIaGFIVFAVSIifavRTGNLYVSIFWLSLGLGGIGI---SMGMSWAAAT 350
Cdd:TIGR00924 60 LVYLLTSVGWWFGDRVWGTKKTMVLGGIVLML-GHFMLAMSI----YPDLIFYGLGTIAVGSGLFKAnpsSMVGKLYERG 134
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 320144554 351 DLGRNFSGTVSGWMNLwgNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAVIMWF 407
Cdd:TIGR00924 135 DMPRRDGGFTLFYMSI--NIGSFISPLLAGVIAENYGYHVGFNLAAVGMVIGLLTFF 189
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
32-404 |
4.06e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 45.30 E-value: 4.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 32 YIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGV 111
Cdd:cd17329 21 FMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 112 GEAPMYP-SNAVFNSFWFSKNeKGRASSALLAGSYFGPVLAPIVTIAIVNaFNWQAVFYIFGAV-GILMAVLWAIIAKDL 189
Cdd:cd17329 101 GGGLFEPaSEAMIADVTTPEN-RTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLfLLAALVLLFLLPETR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 190 PEQHRMVNEAEKRfimenrdivateksspPWNDFFKRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSIss 269
Cdd:cd17329 179 PKRRAAEKTEILR----------------GYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGL-- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 270 lpwllmfFLILSAGAISdrVLGLGRSKFVARG---VIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGGIGISMGMSW 346
Cdd:cd17329 241 -------LLALNALLIV--LLQFPVARLVERFrlrKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQ 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 320144554 347 AAATDL-GRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAVI 404
Cdd:cd17329 312 TLVAALaPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAA 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
237-405 |
1.01e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.51 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 237 FVVQFIITLFLIWLPTYLTEVFHVnfkemSISSLPWLLMFFLILSA------GAISDRVlglgRSKFVARGVIAIAGFIV 310
Cdd:COG2211 20 LGLNLAFGLLSAYLLYFYTDVLGL-----SAALVGLILLVARLWDAitdpliGALSDRT----RTRWGRRRPWILIGAIP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 311 FAVS--IIFAVRTGNLYVSIFWLSLGLGGIGISMGMS----WAAATDLGRNFS--GTVSGWMNLWGNIGALISPLLAGLF 382
Cdd:COG2211 91 LALSfvLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVnipySALGAELTPDYEerTRLSSWRFAFAGLGGLLASVLPPPL 170
|
170 180
....*....|....*....|...
gi 320144554 383 VEHLGWTMTFQLLIVPAVIAVIM 405
Cdd:COG2211 171 VAAFGGDAALGYRLTALIFAVLG 193
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
11-185 |
1.11e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.14 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 11 MFALAFFFIGVIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFT 90
Cdd:cd17329 201 AFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGF 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 91 ILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYI 170
Cdd:cd17329 281 AVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLI 360
|
170
....*....|....*
gi 320144554 171 FGAVGILMAVLWAII 185
Cdd:cd17329 361 LAALGLIAAALLLGL 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
10-118 |
1.24e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.12 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 10 WMFALAFFFIGVIAYMDRANISYIAKqmmDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAF 89
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLYYFK---YVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110
....*....|....*....|....*....|.
gi 320144554 90 TILTGMIKNH--GLIYLVRFLFGVGEAPMYP 118
Cdd:COG2211 308 LLLLFFLGPGnlWLLLVLAALAGIGLGAILV 338
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
272-410 |
1.31e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 43.83 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 272 WLLMFFLI--LSAGAISDRvlgLGRSKFVargVIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGG---IGISMGMSW 346
Cdd:cd17371 42 VTLAGGAIggILGGILADR---FGRVRVL---VITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGewaAGAALMAEY 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320144554 347 AAATDLGRNFSGTVSGWMNLWGnIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAVIMWFYVK 410
Cdd:cd17371 116 VPARHRGKALGYVQSGWAVGWL-LATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVK 178
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
10-191 |
1.40e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 43.71 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 10 WMFALAFFFIGVIAYMdraNISYIAkQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRK--MITIALVWWS 87
Cdd:COG2807 218 WLLTLFFGLQSLLYYA---VVAWLP-PILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRplLLLLGLLGLA 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 88 AFTILtgMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWF-SKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAF-NWQ 165
Cdd:COG2807 294 GLLGL--LLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRArTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATgSWT 371
|
170 180
....*....|....*....|....*.
gi 320144554 166 AVFYIFGAVGILMAVLWAIIAKDLPE 191
Cdd:COG2807 372 AALLLLAALAVLMLVAGLLAGRPYVE 397
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
37-185 |
1.60e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 43.34 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 37 MMDDLGMTKPQFGLLASFFSLGYALMQVP-SGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAP 115
Cdd:cd17330 201 LKDRFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGI 280
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 116 MYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVtIAIVNAFNWQAVFYIFGAVGILMAVLWAII 185
Cdd:cd17330 281 VFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLL-AGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
237-422 |
1.60e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 43.72 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 237 FVVQFIITLFLIWLPtyltEVFHVNFKEMS-ISSLPWLLMFFLILSAGAISDRvlglgrskFVARGVIAIAGFIVFAVSI 315
Cdd:COG2223 18 FGVWYLWSVLAPPLA----EEFGLSAAQLGlLFAIPVLVGALLRIPLGFLVDR--------FGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 316 IFAvrtgnlYVSIFWLSLGLGGI-GISMGMSWAAATDLGRNFS-----GTVSGWMNLWGNIGALISPLLAGLFVEHLGWT 389
Cdd:COG2223 86 LLA------LAVSYWLLLLLGLLlGIGGGGSFAVGIALVSKWFppdrrGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190
....*....|....*....|....*....|....
gi 320144554 390 MTFQLLIVP-AVIAVIMWFYVKPDQPLIVSDDKA 422
Cdd:COG2223 160 NAFLILGILlLVVAVLAWLFLRDPPAGAAAAAKA 193
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-183 |
1.69e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.36 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 9 RWMFALAFFFIGVIAYMDRANI-----------------SYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAE 71
Cdd:cd17316 159 RILFLIGALPALLALLLRRRTLllillwffisfgyygltTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 72 KFGPRKMITIALVWWSAFTILTGMIKNHGLIYL--VRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPV 149
Cdd:cd17316 239 RIGRKKTLVIGLILSGILALPLFYLLSGSPTLLllLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGG 318
|
170 180 190
....*....|....*....|....*....|....*
gi 320144554 150 LAP-IVTIAIVNAFNWQAVFYIFGAVGILMAVLWA 183
Cdd:cd17316 319 GAPpLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
10-186 |
1.93e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 43.33 E-value: 1.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 10 WMFALAFFFIGVIAYMDRANISYIakqmMDDLGMTKP-QFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSA 88
Cdd:cd17473 200 LPIYFLAFLAMLLFYVIPIQLPFL----LQERGGGSAaLIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 89 FTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNA-FNWQAV 167
Cdd:cd17473 276 GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLtGGLSGA 355
|
170
....*....|....*....
gi 320144554 168 FYIFGAVGILMAVLWAIIA 186
Cdd:cd17473 356 FLILGVLALVLAIVLLLLR 374
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
36-181 |
2.01e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 43.36 E-value: 2.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 36 QMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAE-KFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEA 114
Cdd:cd17490 220 LIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYkKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTG 299
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320144554 115 PMYPsnaVFNSFWFSKNEKGRASSAL-------LAGSYFGPVLAPIvtiaIVNAFNWQAVFYIFGAVGILMAVL 181
Cdd:cd17490 300 ILFP---LLMSLSIEGVPAEQRSTAMgffqaiyALGMFLGPVLVGI----ISEAFGLQTGFFVIGVIALLAAIL 366
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
237-422 |
3.77e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.54 E-value: 3.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 237 FVVQFIITLFLIWLPtYLTEVFHVNFKEMSIsslpwLLMFFLILSA------GAISDRVlglgrskfvARGVIAIAGFIV 310
Cdd:cd17478 6 FLNDFYQGFLPALLP-LLIAKLGLSYAQAGL-----LVSVFSITSSllqplfGYLADRK---------PRRYLLPLGPLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 311 FAVSIIFAVRTGNLYvsIFWLSLGLGGIGISM----GMSWAAATDLGRNfsGTVSGWMNLWGNIGALISPLLAGLFVEHL 386
Cdd:cd17478 71 TGLGLSLLGFAPNYW--LLLLLVALAGIGSAAfhpeGARLASQAAGGRR--GLAMSIFSVGGNLGFALGPLIAAALVALF 146
|
170 180 190
....*....|....*....|....*....|....*.
gi 320144554 387 GWTMTFQLLIVPAVIAVIMWFYVKPDQPLIVSDDKA 422
Cdd:cd17478 147 GGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAA 182
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
2-152 |
4.00e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.41 E-value: 4.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 2 KEKRTNVRWMFALAFFFIGVIAYMdranISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITI 81
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAFFG----LLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320144554 82 A---LVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAP 152
Cdd:pfam07690 271 AlllLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
9-164 |
4.10e-04 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 42.66 E-value: 4.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 9 RWMFALaFFFIGVIAYMDRANI---SYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVW 85
Cdd:TIGR01299 163 RFQWAL-FFVLGLALMADGVEVfvvGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSV 241
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320144554 86 WSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNW 164
Cdd:TIGR01299 242 NGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGW 320
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
39-181 |
4.88e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 41.86 E-value: 4.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 39 DDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYP 118
Cdd:cd17476 26 DSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLP 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320144554 119 SN-AVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVL 181
Cdd:cd17476 106 NAmALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVA 169
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
47-410 |
5.85e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.78 E-value: 5.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 47 QFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSF 126
Cdd:cd17502 31 LVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIAD 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 127 WFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLwaiiakdLPeqhrmvneaekrfime 206
Cdd:cd17502 111 LVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALAL-------LR---------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 207 nrdivatekssppwndffkrfSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSISSLPwlLMFFLILSAgAIS 286
Cdd:cd17502 168 ---------------------TILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLP--LIIGLVIGS-IIS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 287 DRVLG-LGRSKFvargVIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGGIGISMGMS---WAAATDLGRNFSGTVSG 362
Cdd:cd17502 224 GALISkTGRYKP----LIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQqplVAVQNAVPPADVGVATA 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 320144554 363 WMNLWGNIGALISpllaglfvehLGWTMTFQLLIVPAVIAVIMWFYVK 410
Cdd:cd17502 300 TNTFFRSLGGTLG----------VAITDVFLVALALAALAFLLSLFLP 337
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
18-92 |
9.92e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 40.95 E-value: 9.92e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320144554 18 FIGVIAYM--DRANISYIAKQMMDdLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTIL 92
Cdd:cd17337 3 YIGVLLFMigDGVEQGFLSPYLVD-LGFSEAQAALLFTVYGLTVAIASWLSGVLAELFGPRRVMLIGLIIWLVFEVL 78
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
49-185 |
1.01e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.15 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 49 GLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWF 128
Cdd:TIGR00898 130 DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFL 209
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 320144554 129 SKneKGRASSALLAGSYF--GPVLAPIVTIAIVnafNWQAVFYIFGAVGILMAVLWAII 185
Cdd:TIGR00898 210 PK--KQRAIVGTLIQVFFslGLVLLPLVAYFIP---DWRWLQLAVSLPTFLFFLLSWFV 263
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
21-194 |
1.28e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 40.83 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 21 VIAYMDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHG 100
Cdd:TIGR00711 12 FMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 101 LIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAV 180
Cdd:TIGR00711 92 LMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVV 171
|
170
....*....|....
gi 320144554 181 LWAIIAKDLPEQHR 194
Cdd:TIGR00711 172 VAFFILPRDKPAAS 185
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
36-382 |
1.43e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 40.64 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 36 QMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAP 115
Cdd:cd17504 21 TIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 116 MYPSNAVFNSFWfsKNEKGRASSALLAGSY-FGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIAKDLpeqhr 194
Cdd:cd17504 101 FPLAFALVREEF--PPERVPVAQGILSATFgIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDLRL----- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 195 mvneaekrfimenrdivatekssppwndfFKRFSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSISSLPWLL 274
Cdd:cd17504 174 -----------------------------LRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 275 MFFLIlsaGAISDRVLGLGRSKFVARgVIAIAGFIVFAVSIIFAVRTGnlyVSIFWLSLGLGGIGISMGMSWAAATDL-- 352
Cdd:cd17504 225 PGALV---MLIAGPLAGRLIARVGPR-RVLLIGLVISAVGLLLLALLH---SSLWALVVALLLIGIGLGLAFASLPNIvv 297
|
330 340 350
....*....|....*....|....*....|...
gi 320144554 353 ---GRNFSGTVSGWMNLWGNIGALISPLLAGLF 382
Cdd:cd17504 298 esvPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
6-187 |
1.46e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 40.64 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 6 TNVRWMFALAFFFIGVIAYMDRANISYIakqMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVW 85
Cdd:cd17335 196 RNPRVLAFLLVAFLMGFGHGLIYSFLFW---HLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLA 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 86 WSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRAsSALLAGSYFGPVLAPIVTIA--IVNAFN 163
Cdd:cd17335 273 YVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATA-QGLLQGLYFGLGGGLGSLIGgyLYEAFG 351
|
170 180
....*....|....*....|....
gi 320144554 164 WQAVFYIFGAVGILMAVLWAIIAK 187
Cdd:cd17335 352 ARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
53-187 |
1.55e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 40.26 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 53 SFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNE 132
Cdd:cd17317 32 TIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 320144554 133 KGRASSALLAGSYFGPVLAPIVTIAIVnafNWQAVFYIFGAVGILMAVLWAIIAK 187
Cdd:cd17317 112 RSFVGILFGLFWALGYMLLALLAYLIR---DWRWLQLAISLPGLLFLLLLWWLPR 163
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
39-405 |
2.27e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.84 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 39 DDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKM-ITIALVWWSAFTILTGMIKNHGLIYLVRFLFgvgeapMY 117
Cdd:cd17471 25 EELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPlILLALLAGALGYLLFAFLRNYWVLLLVGVVL------LS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 118 PSNAVFNSFW---------FSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIfgaVGILMAVLWAIIAKD 188
Cdd:cd17471 99 LGAAAFPQLFalareyadrSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLL---AALLYLVVALLVLFL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 189 LPEQHRmvneaekrfimenrDIVATEKSSPPWNDFFKRfSFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNFKEMSI- 267
Cdd:cd17471 176 LPSVKP--------------PAQKATPASSLVKAPVNR-RLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLl 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 268 SSLPWLLMFFLILSAGAISDRvlgLGRSKFVArgvIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGgIGISMGMSWA 347
Cdd:cd17471 241 FGLAAALEIPIMLLAGLLAKR---FGKRRLLL---AGFLAGVLFYLGLALATSLWQLIALQLLNAIFIG-ITAGLGISYF 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 320144554 348 aaTDLGRNFSGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAVIM 405
Cdd:cd17471 314 --QDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVL 369
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
16-164 |
2.35e-03 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 40.01 E-value: 2.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 16 FFFIGVIAYMDRANI---SYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTIL 92
Cdd:cd17439 1 YFVLGLALMADGVEVfvvGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFF 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 320144554 93 TGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNW 164
Cdd:cd17439 81 SSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGW 152
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
283-409 |
2.62e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 39.65 E-value: 2.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 283 GAISDRvlgLGRSKFVargVIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGLGGI-GISMGMSWAAATDlgrNFSGTVS 361
Cdd:TIGR00895 73 GPLADR---IGRRRVL---LWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLmPNLNALVSEYAPK---RFRGTAV 143
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 320144554 362 GWMNLWGNIGALISPLLAGLFVEHLGWTMTFQL-LIVPAVIAVIMWFYV 409
Cdd:TIGR00895 144 GLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVgGIAPLLLLLLLMRFL 192
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
48-405 |
2.65e-03 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 39.61 E-value: 2.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 48 FGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGM-----IKNHGLIYLVRFLFGVGEAPMYPSNAV 122
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLgyywnIHSLWYFVVVQILAGLFQSTGWPSVVA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 123 FNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNaFNWQAVFYIfgaVGILMAVLWAIIAKDLPEqhrmvneaekr 202
Cdd:cd17344 144 CVGNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFVS-SAWGLSFIV---PGIIIAAMGVLVFLFLVE----------- 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 203 fimenrdivateksSPPWNDFFKRFSFYAIAIQYfvvqfiitLFLIWLPTYLTEVFHVNFKEMS-ISSLPWLLMFFLILS 281
Cdd:cd17344 209 --------------HPPGVIEFSLCLFFAKLVSY--------TFLYWLPLYISNTAILSAKKAGdLSTLFDVGGIVGGIL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 282 AGAISDRvlgLGRSKFVARGVIAIAGFIVFAVSIIFAVrtgNLYVSIFWLSL-GLGGIGISMGMSWAAATDLGRNFS--- 357
Cdd:cd17344 267 AGYISDY---TGGRATTCAAMLILAAPMLFIYNYFGQV---SMTTNIVLLIVcGLLVNGPYALITTAVSADLGTHKSlkg 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 320144554 358 -----GTVSGWMNLWGNIGALISPLLAGLfVEHLGWTMTFQLLIVPAVIAVIM 405
Cdd:cd17344 341 naralATVTAIIDGTGSIGAALGPLLAGL-ISSRGWNNVFYMLIAADVCAGLL 392
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
247-340 |
3.80e-03 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 39.26 E-value: 3.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 247 LIWLPTYLTEVFHVNFKEMSISSLP-WLLMFFLILSAGAISDRVlglGRSKFVArgvIAIAGFIVFAVSIIFAVRTGnly 325
Cdd:cd17366 213 LSYMPSYLEETLGYSETHGLLVIIIiMVTMLVLQPFLGRLSDRV---GRKPVYA---AGLAGLLVLAVPAFLLMNSG--- 283
|
90
....*....|....*
gi 320144554 326 vSIFWLSLGLGGIGI 340
Cdd:cd17366 284 -SIAAIFIGLLVLGL 297
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
282-414 |
3.86e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.10 E-value: 3.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 282 AGAISDRVlglGRSKFVargviaIAGFIVFAVSIIFAVRTGNLYVSIFWLSLGlggiGISMGMSWAAATDL-----GRNF 356
Cdd:cd17325 51 AGRLSDRF---GRKRLL------LLGLLLLAVSTLLFAFATSYWQLLLARFLQ----GLASAAVWPAAMALiadiaPPEE 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 320144554 357 SGTVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAVIMWFYVKPDQP 414
Cdd:cd17325 118 RGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR 175
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
49-180 |
4.84e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 39.13 E-value: 4.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 49 GLLASFFSLGyALMQVPS-GMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFW 127
Cdd:PRK09874 261 GMIASVPGVA-ALLSAPRlGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYN 339
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 320144554 128 FSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAV 180
Cdd:PRK09874 340 SSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAV 392
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
36-188 |
6.64e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 38.46 E-value: 6.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 36 QMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGpRKMITI--ALVWWSAfTILTGMIKNHGLIYLVRFLFGVGE 113
Cdd:PRK10473 28 RIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSG-RKPVAIpgAALFIIA-SLLCSLAETSSLFLAGRFLQGIGA 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320144554 114 APMYPsnAVFNSFWFSKNEKGRAS--SALLAGSYFGPVLAPIVTIAIVNAFNWQAVFYIFGAVGILMAVLWAIIAKD 188
Cdd:PRK10473 106 GCCYV--VAFAILRDTLDDRRRAKvlSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKE 180
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
55-401 |
7.16e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 38.35 E-value: 7.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 55 FSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEApmypSNAVFNsfWFS---KN 131
Cdd:cd17472 41 YGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAI----SSVVMA--LLAdltRE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 132 EKGRASSALLAGSY-----FGPVLAPIvtiaIVNAFNWQAVFYIFGAVGI--LMAVLWAIIAKDLPEQHRMVNEAEKRFI 204
Cdd:cd17472 115 ENRTKAMALIGASIgiafaISMVLGPL----LAAHLGVSGLFLITAILSLvsLLILLFFVPDPPKIVQISEKEKKKLKKL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 205 MENRDivatekssppwndffkrfsFYAIAIQYFVVQFIITLFLIWLPTYLTEVFHVNfKEMSISSLPWLLMFFLILSAGA 284
Cdd:cd17472 191 LKNKR-------------------LLRLDFSIFILHFVLMAFFYILPLLLTQLGGGK-GQLWKVYLPAILIGFILMVPFV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 285 ISDRVLGLGRSkfvargvIAIAGFIVFAVSIIFavrTGNLYVSIFWLSLGL-----GGIGISMGMSWAAATDLGRNFSGT 359
Cdd:cd17472 251 IYAEKKGKMKQ-------VFVSSILLIAVGFLL---LLFAATSLWLLIIGLiiffiGFNLLEALLPSLVSKIAPKEYRGT 320
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 320144554 360 VSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVI 401
Cdd:cd17472 321 AMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALL 362
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
25-194 |
7.37e-03 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 38.26 E-value: 7.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 25 MDRANISYIAKQMMDDLGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYL 104
Cdd:cd17441 13 MEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 105 VRFL--FGVGEAPMypSNAVFNSFWFSKNekgRASSALLAGSY--FGPVLAPIVTIAIVNAFNWQAVFyIFGAVGILmav 180
Cdd:cd17441 93 LRGLvgFGIGGVPQ--SVTLYAEFLPMKS---RAKCILLIEVFwaLGTVFEVLLAVFVMPTLGWRWLL-ILSALPLL--- 163
|
170
....*....|....
gi 320144554 181 LWAIIAKDLPEQHR 194
Cdd:cd17441 164 IFAVLCFWLPESAR 177
|
|
| MFS_CynX_like |
cd17410 |
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of ... |
267-413 |
8.01e-03 |
|
Cyanate transport protein CynX and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli cyanate transport protein CynX and similar proteins. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The gene encoding CynX is part of the cyn operon that also includes cynS, encoding cynase, which catalyzes the reaction of cyanate with bicarbonate to give ammonia and carbon dioxide, and cynT, which encodes a carbonic anhydrase. The CynX-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340968 [Multi-domain] Cd Length: 372 Bit Score: 38.16 E-value: 8.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 267 ISSLPWLLMFFLILSAGAISDRVlglGRSKFVARGVIAIAGfivfAVSIIFAVRTGNLYVSifwlSLGLGGIGISMGMSW 346
Cdd:cd17410 39 LTVLPVLCMGLVALLGPWLARRV---GERRGVALSLLAIAA----ACLWRLWSGTGPTLIA----SALLGGLGIAIIQAL 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320144554 347 AAATdLGRNFSGTVSGWMNLW-------GNIGALISPLLAGlfvEHLGWTMTFQLLIVPAVIAVIMWFYVKPDQ 413
Cdd:cd17410 108 VPGL-IKRRFPARVPLAMGLYsaslmagGGLAASLSPRLAQ---HSAGWQLGLGIWAVPALVALVLWWRQPPRE 177
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
5-181 |
8.54e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 37.97 E-value: 8.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 5 RTNVRWMFALAFFFIGVIAYMDRANISYIAKQMMddlGMTKPQFGLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALV 84
Cdd:cd17353 211 RTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFA---GLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 85 WWS-AFTILTGMIKNHGLIYLVRFLFGVGEAPMYPSNAVFNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVNAFN 163
Cdd:cd17353 288 IQGvAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGG 367
|
170
....*....|....*...
gi 320144554 164 WQAVFYIFGAVGILMAVL 181
Cdd:cd17353 368 YNAAFIIAAALSLVALAL 385
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
280-410 |
8.63e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 38.00 E-value: 8.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 280 LSAGAISDRVLGLGRSKFVAR--GVIAIAGFIVFAVSIIFAVRTGNLYVSIFWLsLGLGGIGISMGMSWAaatdlGRNFS 357
Cdd:cd17341 44 VLAGALLRLPYGFLCDRFGGRrvFIASLLLLLIPLLALALAVSSYWGLLVLGFL-LGFAGANFASGQPWA-----SFWFP 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320144554 358 GTVSGWMNL----WGNIGALISPLLAGLFVE-------HLGWTMTFQLLIVPAVI-AVIMWFYVK 410
Cdd:cd17341 118 KEKIGGAAGgiagAGNMGVAVSQLLAPLIAGaivfdggFVGWRNAFFVPGILLAIaAVLVLLFGD 182
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
39-190 |
8.82e-03 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 38.37 E-value: 8.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 39 DDLGMTKPQFGLlASFFSL-GYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIKNHGLIYLVRFLFGVGEApmy 117
Cdd:PLN00028 64 DNLNLTKSDIGN-AGIASVsGSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLA--- 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 118 psNAVFNSFW----FSKNEKGRASsALLAG---------SYFGPVLAPIVTIAIVNAFN-WQAVFYIFGAVGILMAVLWA 183
Cdd:PLN00028 140 --TFVSCQYWmstmFNGKIVGTAN-GIAAGwgnlgggvtQLLMPLVFPLIKDAGAPSFTaWRIAFFVPGLLHIIMGILVL 216
|
....*..
gi 320144554 184 IIAKDLP 190
Cdd:PLN00028 217 TLGQDLP 223
|
|
| MFS_MFSD12 |
cd17491 |
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ... |
174-364 |
9.07e-03 |
|
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341044 Cd Length: 438 Bit Score: 38.01 E-value: 9.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 174 VGILMAVLWAIIAKDLPEQHRMVNEAEkrfimENRDIVATEKSSPPWNDFFKRFSFYAIAIQYFVVQFIITLFLIWLPTY 253
Cdd:cd17491 196 IGFLFSLLFHLGTKEPRPPTDLSTTTN-----EGEEVTAPEEPRLTWKEWLREPQFYQVALLYMCTRLIVNLSQVYIPLY 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 254 LTEVFHvnFKEMSISSLPwLLMFFlilsAGAISDRVLGLGRSKFVARGVIAIAGFIVFAVSIIFAVRTGNLYVSIFWLSL 333
Cdd:cd17491 271 LTETLQ--LPKESIAIVP-LVMYV----SGFLTSLVMKPINKKIGRKITYLLGLLFVLGFCIWVWFQSGSSRTYEIYGAA 343
|
170 180 190
....*....|....*....|....*....|....*.
gi 320144554 334 GLGGIGISMG--MSWAAATDLGRNFSGT---VSGWM 364
Cdd:cd17491 344 VLLGVGSATLlvTSLSMTADLIGTNTESgafVYGAM 379
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
49-404 |
9.61e-03 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 38.06 E-value: 9.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 49 GLLASFFSLGYALMQVPSGMLAEKFGPRKMITIALVWWSAFTILTGMIK------NHGLIYLVRFLFGVGEAPMYPSNAV 122
Cdd:cd17342 66 GVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTewlhfyNKYLYCILWVLNGLLQSTGWPCVVA 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 123 FNSFWFSKNEKGRASSALLAGSYFGPVLAPIVTIAIVN-----AFNWQAVFYIFGAVGILMAVLwaiiakdlpeqhrmvn 197
Cdd:cd17342 146 IMGNWFGKSSRGFVLGLWSACASVGNIIGALLASSVLDygyeyAFLVTSSLLFAGAIVVFFGLL---------------- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 198 eaekrfimenrdivatekSSPPwndffkRFSFYAIAiqYFVVQFIITLFLIWLPTYLTEVFHvnFKEMSISSLPWLLMFF 277
Cdd:cd17342 210 ------------------SSPP------GVIPYSLA--YACLKLVNYSFFFWLPFYLSNNFH--WKESEADQLSIWYDVG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320144554 278 LILS---AGAISDRVlglgrskfVARGVIAIAgFIVFAVSIIFAVRtgNLYVSIFWLSLGLGGIGISMG-----MSWAAA 349
Cdd:cd17342 262 GIIGgivAGYISDRM--------GSRSPVVVV-MLLLAIPSLFVYS--HSPSDKVLNAFVMTITGFFIGgpanlISSAIS 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320144554 350 TDLGRN--FSG------TVSGWMNLWGNIGALISPLLAGLFVEHLGWTMTFQLLIVPAVIAVI 404
Cdd:cd17342 331 ADLGRQpqLRGssealaTVTGIIDGTGSIGAAIGQVLVPLIQNRLGWMWVFYFFIIMTILTIV 393
|
|
| |
