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Conserved domains on  [gi|313837876|gb|EFS75590|]
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acetyltransferase, GNAT family, partial [Cutibacterium modestum HL037PA2]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11418877)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 102-169 5.49e-08

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 48.11  E-value: 5.49e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 313837876 102 YVAPPARRhgpmlmcvhavprtQGHGSQILTQVCQWADEHG---LTLELKPSGPAAERFYKRFGFVKTSRR 169
Cdd:COG0456   20 AVDPEYRG--------------RGIGRALLEAALERARERGarrLRLEVREDNEAAIALYEKLGFEEVGER 76
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 102-169 5.49e-08

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 48.11  E-value: 5.49e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 313837876 102 YVAPPARRhgpmlmcvhavprtQGHGSQILTQVCQWADEHG---LTLELKPSGPAAERFYKRFGFVKTSRR 169
Cdd:COG0456   20 AVDPEYRG--------------RGIGRALLEAALERARERGarrLRLEVREDNEAAIALYEKLGFEEVGER 76
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 102-165 3.72e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 43.21  E-value: 3.72e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 313837876  102 YVAPPARRhgpmlmcvhavprtQGHGSQILTQVCQWADEHGLTLELKPSGPAAERFYKRFGFVK 165
Cdd:pfam13508  35 AVHPEYRG--------------QGIGRALLEAAEAAAKEGGIKLLELETTNRAAAFYEKLGFEE 84
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 116-169 1.13e-04

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 40.00  E-value: 1.13e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 313837876  116 CVHAVPRTQGHGSQILTQVCQWADEHG---LTLELKPSGPAAERFYKRFGFVKTSRR 169
Cdd:TIGR01575  61 AVKPEYQGQGIGRALLRELIDEAKGRGvneIFLEVRVSNIAAQALYKKLGFNEIAIR 117
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 102-169 5.49e-08

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 48.11  E-value: 5.49e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 313837876 102 YVAPPARRhgpmlmcvhavprtQGHGSQILTQVCQWADEHG---LTLELKPSGPAAERFYKRFGFVKTSRR 169
Cdd:COG0456   20 AVDPEYRG--------------RGIGRALLEAALERARERGarrLRLEVREDNEAAIALYEKLGFEEVGER 76
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 102-170 3.52e-07

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 46.97  E-value: 3.52e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 313837876 102 YVAPPARRhgpmlmcvhavprtQGHGSQILTQVCQWADEHGLT---LELKPSGPAAERFYKRFGFVKTSRRV 170
Cdd:COG0454   65 YVLPEYRG--------------KGIGKALLEALLEWARERGCTaleLDTLDGNPAAIRFYERLGFKEIERYV 122
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 102-165 3.72e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 43.21  E-value: 3.72e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 313837876  102 YVAPPARRhgpmlmcvhavprtQGHGSQILTQVCQWADEHGLTLELKPSGPAAERFYKRFGFVK 165
Cdd:pfam13508  35 AVHPEYRG--------------QGIGRALLEAAEAAAKEGGIKLLELETTNRAAAFYEKLGFEE 84
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 115-168 4.72e-05

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 41.13  E-value: 4.72e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 313837876 115 MCVHAVPRTQGHGSQILTQVCQWADEHGL-TLELKpSGPAAERFYKRFGFVKTSR 168
Cdd:COG1246   58 LAVHPDYRGRGIGRRLLEALLAEARELGLkRLFLL-TTSAAIHFYEKLGFEEIDK 111
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
115-174 4.88e-05

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 40.94  E-value: 4.88e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313837876 115 MCVHAVPRTQGHGSQILTQVCQWADEHGLTlELKPSGPA-AERFYKRFGFVKTS---------RRVMRRE 174
Cdd:COG2153   64 VAVLPEYRGQGLGRALMEAAIEEARERGAR-RIVLSAQAhAVGFYEKLGFVPVGeefleagipHIDMRKP 132
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 46-163 1.05e-04

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 39.81  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313837876   46 RDWIICGNWPGQGELAMIGAATLVVVAVIMVALEAHHWRTATWRSWqttpdwhggaYVAPPARRhgpmlmcvhavprtQG 125
Cdd:pfam00583  20 PLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEPPVGEIEGL----------AVAPEYRG--------------KG 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 313837876  126 HGSQILTQVCQWADEHGLT---LELKPSGPAAERFYKRFGF 163
Cdd:pfam00583  76 IGTALLQALLEWARERGCErifLEVAADNLAAIALYEKLGF 116
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 116-169 1.13e-04

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 40.00  E-value: 1.13e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 313837876  116 CVHAVPRTQGHGSQILTQVCQWADEHG---LTLELKPSGPAAERFYKRFGFVKTSRR 169
Cdd:TIGR01575  61 AVKPEYQGQGIGRALLRELIDEAKGRGvneIFLEVRVSNIAAQALYKKLGFNEIAIR 117
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
115-173 5.69e-04

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 37.20  E-value: 5.69e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 313837876 115 MCVHAVPRTQGHGSQILTQVCQWADEHG---LTLELKPSGPAAERFYKRFGFVKTSRRVMRR 173
Cdd:COG3393   21 VYTHPEYRGRGLASALVAALAREALARGartPFLYVDADNPAARRLYERLGFRPVGEYATVL 82
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
86-169 1.38e-03

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 37.28  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313837876  86 ATWRSWQTTPDWHGGA----YVAPPARRhgpmlmcvhavprtQGHGSQILTQVCQWADEHG---LTLELKPSGPAAERFY 158
Cdd:COG1247   67 ASLGPFRPRPAYRGTAeesiYVDPDARG--------------RGIGRALLEALIERARARGyrrLVAVVLADNEASIALY 132

                         90
                 ....*....|.
gi 313837876 159 KRFGFVKTSRR 169
Cdd:COG1247  133 EKLGFEEVGTL 143
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 114-172 2.33e-03

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 36.48  E-value: 2.33e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 313837876  114 LMCVHAVPRTQGHGSQILTQVCQWADEHGL---TLELKPSgPAAERFYKRFGFVKTSRRVMR 172
Cdd:pfam13673  56 LLFVDPDYQGQGIGKALLEAVEDYAEKDGIklsELTVNAS-PYAVPFYEKLGFRATGPEQEF 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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