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Conserved domains on  [gi|311324312|gb|EFQ90731|]
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hypothetical protein PTT_12608 [Pyrenophora teres f. teres 0-1]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-333 9.87e-45

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.77  E-value: 9.87e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312   6 TTPIAKLTGHTGLVHAVAYSSGAQTyILTGSSDRQIRLYNPSKAPpsslapatssqppagLVNKYTAHGYEVLSLAIAAS 85
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSPDGKT-LASGSADGTVRLWDLATGK---------------LLRTLTGHSGAVTSVAFSPD 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312  86 NDKFVSTGGDKTVFLWDVQTAQTIQRWTGHAGRVNRGVFGGDDDgVVVTGSFDGTVRVWDTKSRahKPIMTLSDAKDSIS 165
Cdd:COG2319  174 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATG--KLLRTLTGHSGSVR 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 166 DIAVH-DAQILA-ASVDGRVRCYDIRTGMCEVDIIGTSC--TSLDISKKGTEVLVSSLDSTIRLMDRENGEMLKKYTDEa 241
Cdd:COG2319  251 SVAFSpDGRLLAsGSADGTVRLWDLATGELLRTLTGHSGgvNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH- 329

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 242 fvnkELRVRS-TLGLNDSVVLSGSDDGMVFAWDMLGGTCLHRFkhsemrevegltaavqakaKGKKDVVSAVAFCEKRRE 320
Cdd:COG2319  330 ----TGAVRSvAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-------------------TGHTGAVTSVAFSPDGRT 386

                        330
                 ....*....|...
gi 311324312 321 WCSGGGDGNVVVW 333
Cdd:COG2319  387 LASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-333 9.87e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.77  E-value: 9.87e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312   6 TTPIAKLTGHTGLVHAVAYSSGAQTyILTGSSDRQIRLYNPSKAPpsslapatssqppagLVNKYTAHGYEVLSLAIAAS 85
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSPDGKT-LASGSADGTVRLWDLATGK---------------LLRTLTGHSGAVTSVAFSPD 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312  86 NDKFVSTGGDKTVFLWDVQTAQTIQRWTGHAGRVNRGVFGGDDDgVVVTGSFDGTVRVWDTKSRahKPIMTLSDAKDSIS 165
Cdd:COG2319  174 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATG--KLLRTLTGHSGSVR 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 166 DIAVH-DAQILA-ASVDGRVRCYDIRTGMCEVDIIGTSC--TSLDISKKGTEVLVSSLDSTIRLMDRENGEMLKKYTDEa 241
Cdd:COG2319  251 SVAFSpDGRLLAsGSADGTVRLWDLATGELLRTLTGHSGgvNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH- 329

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 242 fvnkELRVRS-TLGLNDSVVLSGSDDGMVFAWDMLGGTCLHRFkhsemrevegltaavqakaKGKKDVVSAVAFCEKRRE 320
Cdd:COG2319  330 ----TGAVRSvAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-------------------TGHTGAVTSVAFSPDGRT 386

                        330
                 ....*....|...
gi 311324312 321 WCSGGGDGNVVVW 333
Cdd:COG2319  387 LASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-273 9.09e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.01  E-value: 9.09e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312   7 TPIAKLTGHTGLVHAVAYSSgAQTYILTGSSDRQIRLYNPSKAPpsslapatssqppagLVNKYTAHGYEVLSLAIAASN 86
Cdd:cd00200   42 ELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGE---------------CVRTLTGHTSYVSSVAFSPDG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312  87 DKFVSTGGDKTVFLWDVQTAQTIQRWTGHAGRVNRGVFGGDDDgVVVTGSFDGTVRVWDTKSraHKPIMTLSDAKDSISD 166
Cdd:cd00200  106 RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRT--GKCVATLTGHTGEVNS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 167 IAVHD--AQILAASVDGRVRCYDIRTGMCEVDIIG--TSCTSLDISKKGTEVLVSSLDSTIRLMDRENGEMLKKytdeaF 242
Cdd:cd00200  183 VAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGheNGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT-----L 257

                        250       260       270
                 ....*....|....*....|....*....|..
gi 311324312 243 VNKELRVRSTLGLND-SVVLSGSDDGMVFAWD 273
Cdd:cd00200  258 SGHTNSVTSLAWSPDgKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-45 1.28e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.28e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 311324312     7 TPIAKLTGHTGLVHAVAYSSGaQTYILTGSSDRQIRLYN 45
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
7-45 6.76e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 6.76e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 311324312    7 TPIAKLTGHTGLVHAVAYSSGaQTYILTGSSDRQIRLYN 45
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 84-234 7.43e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 37.95  E-value: 7.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312  84 ASNDKFVS----TGGDKTVFLWDV--QTAQTIQRWTGHAGRVNRGVFGGDDDGVVVTGSFDGTVRVWDT-----KSRAHK 152
Cdd:PTZ00421  37 ACNDRFIAvpwqQLGSTAVLKHTDygKLASNPPILLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpeeglTQNISD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 153 PIMTLSDAKDSISDIAVHD--AQILA-ASVDGRVRCYDIRTGM------CEVDIIgtscTSLDISKKGTEVLVSSLDSTI 223
Cdd:PTZ00421 117 PIVHLQGHTKKVGIVSFHPsaMNVLAsAGADMVVNVWDVERGKavevikCHSDQI----TSLEWNLDGSLLCTTSKDKKL 192

                        170
                 ....*....|.
gi 311324312 224 RLMDRENGEML 234
Cdd:PTZ00421 193 NIIDPRDGTIV 203
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-333 9.87e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.77  E-value: 9.87e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312   6 TTPIAKLTGHTGLVHAVAYSSGAQTyILTGSSDRQIRLYNPSKAPpsslapatssqppagLVNKYTAHGYEVLSLAIAAS 85
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSPDGKT-LASGSADGTVRLWDLATGK---------------LLRTLTGHSGAVTSVAFSPD 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312  86 NDKFVSTGGDKTVFLWDVQTAQTIQRWTGHAGRVNRGVFGGDDDgVVVTGSFDGTVRVWDTKSRahKPIMTLSDAKDSIS 165
Cdd:COG2319  174 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATG--KLLRTLTGHSGSVR 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 166 DIAVH-DAQILA-ASVDGRVRCYDIRTGMCEVDIIGTSC--TSLDISKKGTEVLVSSLDSTIRLMDRENGEMLKKYTDEa 241
Cdd:COG2319  251 SVAFSpDGRLLAsGSADGTVRLWDLATGELLRTLTGHSGgvNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH- 329

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 242 fvnkELRVRS-TLGLNDSVVLSGSDDGMVFAWDMLGGTCLHRFkhsemrevegltaavqakaKGKKDVVSAVAFCEKRRE 320
Cdd:COG2319  330 ----TGAVRSvAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-------------------TGHTGAVTSVAFSPDGRT 386

                        330
                 ....*....|...
gi 311324312 321 WCSGGGDGNVVVW 333
Cdd:COG2319  387 LASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
5-333 4.80e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.05  E-value: 4.80e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312   5 PTTPIAKLTGHTGLVHAVAYSSGAQTyILTGSSDRQIRLYNpskappsslapATSSQPPAGLvnkyTAHGYEVLSLAIAA 84
Cdd:COG2319   67 AGALLATLLGHTAAVLSVAFSPDGRL-LASASADGTVRLWD-----------LATGLLLRTL----TGHTGAVRSVAFSP 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312  85 SNDKFVSTGGDKTVFLWDVQTAQTIQRWTGHAGRVNRGVFGGDDDgVVVTGSFDGTVRVWDTKSRahKPIMTLSDAKDSI 164
Cdd:COG2319  131 DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATG--KLLRTLTGHTGAV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 165 SDIAVH-DAQILA-ASVDGRVRCYDIRTGMCEVDIIGTS--CTSLDISKKGTEVLVSSLDSTIRLMDRENGEMLKKYTDE 240
Cdd:COG2319  208 RSVAFSpDGKLLAsGSADGTVRLWDLATGKLLRTLTGHSgsVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 241 AFvnkelRVRS-TLGLNDSVVLSGSDDGMVFAWDMLGGTCLHRFkhsemrevegltaavqakaKGKKDVVSAVAFCEKRR 319
Cdd:COG2319  288 SG-----GVNSvAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-------------------TGHTGAVRSVAFSPDGK 343

                        330
                 ....*....|....
gi 311324312 320 EWCSGGGDGNVVVW 333
Cdd:COG2319  344 TLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-273 9.09e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.01  E-value: 9.09e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312   7 TPIAKLTGHTGLVHAVAYSSgAQTYILTGSSDRQIRLYNPSKAPpsslapatssqppagLVNKYTAHGYEVLSLAIAASN 86
Cdd:cd00200   42 ELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGE---------------CVRTLTGHTSYVSSVAFSPDG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312  87 DKFVSTGGDKTVFLWDVQTAQTIQRWTGHAGRVNRGVFGGDDDgVVVTGSFDGTVRVWDTKSraHKPIMTLSDAKDSISD 166
Cdd:cd00200  106 RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRT--GKCVATLTGHTGEVNS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 167 IAVHD--AQILAASVDGRVRCYDIRTGMCEVDIIG--TSCTSLDISKKGTEVLVSSLDSTIRLMDRENGEMLKKytdeaF 242
Cdd:cd00200  183 VAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGheNGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT-----L 257

                        250       260       270
                 ....*....|....*....|....*....|..
gi 311324312 243 VNKELRVRSTLGLND-SVVLSGSDDGMVFAWD 273
Cdd:cd00200  258 SGHTNSVTSLAWSPDgKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
7-274 1.08e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.89  E-value: 1.08e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312   7 TPIAKLTGHTGLVHAVAYSSGAQTyILTGSSDRQIRLYNPSKAPpsslapatssqppagLVNKYTAHGYEVLSLAIAASN 86
Cdd:COG2319  153 KLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGK---------------LLRTLTGHTGAVRSVAFSPDG 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312  87 DKFVSTGGDKTVFLWDVQTAQTIQRWTGHAGRVNRGVFGGDDDgVVVTGSFDGTVRVWDTKSRahKPIMTLSDAKDSISD 166
Cdd:COG2319  217 KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATG--ELLRTLTGHSGGVNS 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 167 IAVH-DAQILA-ASVDGRVRCYDIRTGMCEVDIIGTS--CTSLDISKKGTEVLVSSLDSTIRLMDRENGEMLKKYTDEaf 242
Cdd:COG2319  294 VAFSpDGKLLAsGSDDGTVRLWDLATGKLLRTLTGHTgaVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH-- 371

                        250       260       270
                 ....*....|....*....|....*....|...
gi 311324312 243 vnkELRVRS-TLGLNDSVVLSGSDDGMVFAWDM 274
Cdd:COG2319  372 ---TGAVTSvAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-333 3.68e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.77  E-value: 3.68e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312   8 PIAKLTGHTGLVHAVAYSSGaQTYILTGSSDRQIRLYNpskappsslapatssQPPAGLVNKYTAHGYEVLSLAIAASND 87
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWD---------------LETGELLRTLKGHTGPVRDVAASADGT 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312  88 KFVSTGGDKTVFLWDVQTAQTIQRWTGHAGRVNRGVFgGDDDGVVVTGSFDGTVRVWDTKSRahKPIMTLSDAKDSISDI 167
Cdd:cd00200   65 YLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVETG--KCLTTLRGHTDWVNSV 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 168 AVH--DAQILAASVDGRVRCYDIRTGMCEVDIIG--TSCTSLDISKKGTEVLVSSLDSTIRLMDRENGEMLKKYT-DEAF 242
Cdd:cd00200  142 AFSpdGTFVASSSQDGTIKLWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENG 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 243 VNkELRVrstlGLNDSVVLSGSDDGMVFAWDMLGGTCLHRFkhsemrevegltaavqakaKGKKDVVSAVAFCEKRREWC 322
Cdd:cd00200  222 VN-SVAF----SPDGYLLASGSEDGTIRVWDLRTGECVQTL-------------------SGHTNSVTSLAWSPDGKRLA 277

                        330
                 ....*....|.
gi 311324312 323 SGGGDGNVVVW 333
Cdd:cd00200  278 SGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
7-230 4.18e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.96  E-value: 4.18e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312   7 TPIAKLTGHTGLVHAVAYSSGAQTyILTGSSDRQIRLYNPSKAPpsslapatssqppagLVNKYTAHGYEVLSLAIAASN 86
Cdd:COG2319  195 KLLRTLTGHTGAVRSVAFSPDGKL-LASGSADGTVRLWDLATGK---------------LLRTLTGHSGSVRSVAFSPDG 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312  87 DKFVSTGGDKTVFLWDVQTAQTIQRWTGHAGRVNRGVFGGDDDgVVVTGSFDGTVRVWDTKSRahKPIMTLSDAKDSISD 166
Cdd:COG2319  259 RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRS 335

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 311324312 167 IAVH-DAQILA-ASVDGRVRCYDIRTGMCEVDIIGTS--CTSLDISKKGTEVLVSSLDSTIRLMDREN 230
Cdd:COG2319  336 VAFSpDGKTLAsGSDDGTVRLWDLATGELLRTLTGHTgaVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
71-333 4.03e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 4.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312  71 TAHGYEVLSLAIAASNDKFVSTGGDKTVFLWDVQTAQTIQRWTGHAGRVNRGVFGgDDDGVVVTGSFDGTVRVWDTKSRa 150
Cdd:COG2319   33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-PDGRLLASASADGTVRLWDLATG- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 151 hKPIMTLSDAKDSISDIAVH-DAQILA-ASVDGRVRCYDIRTGMCEVDIIGTS--CTSLDISKKGTEVLVSSLDSTIRLM 226
Cdd:COG2319  111 -LLLRTLTGHTGAVRSVAFSpDGKTLAsGSADGTVRLWDLATGKLLRTLTGHSgaVTSVAFSPDGKLLASGSDDGTVRLW 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 227 DRENGEMLKKYTDEafvnkELRVRS-TLGLNDSVVLSGSDDGMVFAWDMLGGTCLHRFKHSEmrevegltaavqakakgk 305
Cdd:COG2319  190 DLATGKLLRTLTGH-----TGAVRSvAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS------------------ 246

                        250       260
                 ....*....|....*....|....*...
gi 311324312 306 kDVVSAVAFCEKRREWCSGGGDGNVVVW 333
Cdd:COG2319  247 -GSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-45 1.28e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.28e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 311324312     7 TPIAKLTGHTGLVHAVAYSSGaQTYILTGSSDRQIRLYN 45
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 105-145 4.86e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 311324312   105 TAQTIQRWTGHAGRVNRGVFGgDDDGVVVTGSFDGTVRVWD 145
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
7-45 6.76e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 6.76e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 311324312    7 TPIAKLTGHTGLVHAVAYSSGaQTYILTGSSDRQIRLYN 45
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 66-102 1.33e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.33e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 311324312    66 LVNKYTAHGYEVLSLAIAASNDKFVSTGGDKTVFLWD 102
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
107-145 1.74e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.74e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 311324312  107 QTIQRWTGHAGRVNrGVFGGDDDGVVVTGSFDGTVRVWD 145
Cdd:pfam00400   2 KLLKTLEGHTGSVT-SLAFSPDGKLLASGSDDGTVKVWD 39
Luminal_IRE1_like cd09213
The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; The ...
 175-293 4.22e-03

The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; The Luminal domain is a dimerization domain present in Inositol-requiring protein 1 (IRE1), eukaryotic translation Initiation Factor 2-Alpha Kinase 3 (EIF2AK3), and similar proteins. IRE1 and EIF2AK3 are serine/threonine protein kinases (STKs) and are type I transmembrane proteins that are localized in the endoplasmic reticulum (ER). They are kinase receptors that are activated through the release of BiP, a chaperone bound to their luminal domains under unstressed conditions. This results in dimerization through their luminal domains, allowing trans-autophosphorylation of their kinase domains and activation. They play roles in the signaling of the unfolded protein response (UPR), which is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), contains an endoribonuclease domain in its cytoplasmic side and acts as an ER stress sensor. It is the oldest and most conserved component of the UPR in eukaryotes. Its activation results in the cleavage of its mRNA substrate, HAC1 in yeast and Xbp1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. EIF2AK3, also called PKR-like Endoplasmic Reticulum Kinase (PERK), phosphorylates the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. It functions as the central regulator of translational control during the UPR pathway. In addition to the eIF-2 alpha subunit, EIF2AK3 also phosphorylates Nrf2, a leucine zipper transcription factor which regulates cellular redox status and promotes cell survival during the UPR.


Pssm-ID: 188873 [Multi-domain]  Cd Length: 312  Bit Score: 38.63  E-value: 4.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 175 LAASVDGRVRCYDIRTGMCEVDIIGTS-------CTSLDISKKGTEVLVSSLDS--TIRLMDRENGEMLK-KYTDEAFVN 244
Cdd:cd09213    3 LVATLDGTIYAVDASSGEIQWSFDGGGplyssyqSSRDGNAESSSTMLIPSLDGdgNLYQHDKGHGSLQRlPLTIEDLVE 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 311324312 245 KElrVRSTLGLNDSVVLSGSDDGMVFAWDMLGGTCLHRFKHSEMREVEG 293
Cdd:cd09213   83 AS--PLVSDTNEDDVVVVGSKRTSVFALDAKTGKIIKTYRADGLPSTGG 129
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
61-236 5.26e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 37.75  E-value: 5.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312  61 QPPAGLVNKYTAHGYEVLSLAIAASNDKFVSTGGDKTVFLWDVQTAQTIQRWTGHAGRVNRGVFGGDDDG--VVVTGSFD 138
Cdd:COG3391   10 AVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGrrLYVANSGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 139 GTVRVWDTKSRAHKPIMTLSdakDSISDIAVHDAQ---ILAASVDGRVRCYDIRTGMCEVDI-IGTSCTSLDISKKGTEV 214
Cdd:COG3391   90 GRVSVIDLATGKVVATIPVG---GGPRGLAVDPDGgrlYVADSGNGRVSVIDTATGKVVATIpVGAGPHGIAVDPDGKRL 166

                        170       180
                 ....*....|....*....|....*..
gi 311324312 215 LVSSLDST-----IRLMDRENGEMLKK 236
Cdd:COG3391  167 YVANSGSNtvsviVSVIDTATGKVVAT 193
PTZ00421 PTZ00421
coronin; Provisional
 84-234 7.43e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 37.95  E-value: 7.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312  84 ASNDKFVS----TGGDKTVFLWDV--QTAQTIQRWTGHAGRVNRGVFGGDDDGVVVTGSFDGTVRVWDT-----KSRAHK 152
Cdd:PTZ00421  37 ACNDRFIAvpwqQLGSTAVLKHTDygKLASNPPILLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpeeglTQNISD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312 153 PIMTLSDAKDSISDIAVHD--AQILA-ASVDGRVRCYDIRTGM------CEVDIIgtscTSLDISKKGTEVLVSSLDSTI 223
Cdd:PTZ00421 117 PIVHLQGHTKKVGIVSFHPsaMNVLAsAGADMVVNVWDVERGKavevikCHSDQI----TSLEWNLDGSLLCTTSKDKKL 192

                        170
                 ....*....|.
gi 311324312 224 RLMDRENGEML 234
Cdd:PTZ00421 193 NIIDPRDGTIV 203
WD40 pfam00400
WD domain, G-beta repeat;
66-102 8.18e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 8.18e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 311324312   66 LVNKYTAHGYEVLSLAIAASNDKFVSTGGDKTVFLWD 102
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 32-149 9.72e-03

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 37.22  E-value: 9.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311324312  32 ILTGSSDRQIRLYNPSKA--PPSSLAPATSsqPPAGLvnkytaHGYEVlslaiaasndkFVSTGGDKtVFLWDVQTAQTI 109
Cdd:cd22850  208 FVTGTRYGQVRLYDTSAGrrPVFSEKPIKK--PEEDL------DGHTV-----------YVGDTSGD-LALIDIRTGKLL 267

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 311324312 110 QRWTGHAGRVNRGV--FGGDDDGVVVTGSFDGTVRVWDTKSR 149
Cdd:cd22850  268 GRLLGKYGGSITGAvrHPELFDPYLASGGLDRYLRVFDIETR 309
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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