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Conserved domains on  [gi|311315517|gb|EFQ85097|]
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hypothetical protein PTT_20061 [Pyrenophora teres f. teres 0-1]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-317 5.82e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 5.82e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517  62 NLQNDSVAH-FDEHKDSIFCIAQHPvHQEIIATGGGDdvGYII--DVSAAataqpssdgqpteraglKSIFTLDGHKDSV 138
Cdd:cd00200   79 DLETGECVRtLTGHTSYVSSVAFSP-DGRILSSSSRD--KTIKvwDVETG-----------------KCLTTLRGHTDWV 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 139 NAITFTqPKGQFVTTAGLDGKLRVWqgvpDGKKWKFLAE-AQEVEEINWIAsnPSPDHANVVAlGANDGSVWVYQISTEK 217
Cdd:cd00200  139 NSVAFS-PDGTFVASSSQDGTIKLW----DLRTGKCVATlTGHTGEVNSVA--FSPDGEKLLS-SSSDGTIKLWDLSTGK 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 218 gnELQVLQAyylHTETCTAGTWTPDGSLLATISEDSSLYVWDVfgdaASQGLTATtdsqavigLTGHDERfrveggLYSI 297
Cdd:cd00200  211 --CLGTLRG---HENGVNSVAFSPDGYLLASGSEDGTIRVWDL----RTGECVQT--------LSGHTNS------VTSL 267

                        250       260
                 ....*....|....*....|
gi 311315517 298 GIPPSGAFVAVGGPEGQIRI 317
Cdd:cd00200  268 AWSPDGKRLASGSADGTIRI 287
WD40 super family cl43672
WD40 repeat [General function prediction only];
302-460 1.94e-03

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 302 SGAFVAVGGPEGQIRIVGLPRISLAAPAQASTSSSGGGAKNKAGGGKQAGAKGGASSAGQAGQILASLQAGSDNVECLSF 381
Cdd:COG2319    7 AALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 311315517 382 SSLPLTLMAAGNvDGSITLFDTAHRfaVRRRIDDAHADeespqAVVKLDFvakeGPGGWLLTSAGYDGVLRRWDTRGGT 460
Cdd:COG2319   87 SPDGRLLASASA-DGTVRLWDLATG--LLLRTLTGHTG-----AVRSVAF----SPDGKTLASGSADGTVRLWDLATGK 153
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-317 5.82e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 5.82e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517  62 NLQNDSVAH-FDEHKDSIFCIAQHPvHQEIIATGGGDdvGYII--DVSAAataqpssdgqpteraglKSIFTLDGHKDSV 138
Cdd:cd00200   79 DLETGECVRtLTGHTSYVSSVAFSP-DGRILSSSSRD--KTIKvwDVETG-----------------KCLTTLRGHTDWV 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 139 NAITFTqPKGQFVTTAGLDGKLRVWqgvpDGKKWKFLAE-AQEVEEINWIAsnPSPDHANVVAlGANDGSVWVYQISTEK 217
Cdd:cd00200  139 NSVAFS-PDGTFVASSSQDGTIKLW----DLRTGKCVATlTGHTGEVNSVA--FSPDGEKLLS-SSSDGTIKLWDLSTGK 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 218 gnELQVLQAyylHTETCTAGTWTPDGSLLATISEDSSLYVWDVfgdaASQGLTATtdsqavigLTGHDERfrveggLYSI 297
Cdd:cd00200  211 --CLGTLRG---HENGVNSVAFSPDGYLLASGSEDGTIRVWDL----RTGECVQT--------LSGHTNS------VTSL 267

                        250       260
                 ....*....|....*....|
gi 311315517 298 GIPPSGAFVAVGGPEGQIRI 317
Cdd:cd00200  268 AWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
68-458 5.75e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.76  E-value: 5.75e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517  68 VAHFDEHKDSIFCIAQHPVHQeIIATGGGDDVGYIIDVSaaataqpssDGQPteraglksIFTLDGHKDSVNAITFTqPK 147
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSPDGK-TLASGSADGTVRLWDLA---------TGKL--------LRTLTGHSGAVTSVAFS-PD 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 148 GQFVTTAGLDGKLRVWQgVPDGKKWKFL-AEAQEVEEINWiasnpSPDHaNVVALGANDGSVWVYQISTekGNELQVLQA 226
Cdd:COG2319  174 GKLLASGSDDGTVRLWD-LATGKLLRTLtGHTGAVRSVAF-----SPDG-KLLASGSADGTVRLWDLAT--GKLLRTLTG 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 227 yylHTETCTAGTWTPDGSLLATISEDSSLYVWDVfgdaasqgltatTDSQAVIGLTGHDerfrveGGLYSIGIPPSGAFV 306
Cdd:COG2319  245 ---HSGSVRSVAFSPDGRLLASGSADGTVRLWDL------------ATGELLRTLTGHS------GGVNSVAFSPDGKLL 303

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 307 AVGGPEGQIRIVGLprislaapaqastsssgggaknkagggkqagakggassagQAGQILASLQAGSDNVECLSFSSLPL 386
Cdd:COG2319  304 ASGSDDGTVRLWDL----------------------------------------ATGKLLRTLTGHTGAVRSVAFSPDGK 343

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 311315517 387 TLmAAGNVDGSITLFDTAHRFAVRRRidDAHADeespqAVVKLDFVAKegpGGWLLtSAGYDGVLRRWDTRG 458
Cdd:COG2319  344 TL-ASGSDDGTVRLWDLATGELLRTL--TGHTG-----AVTSVAFSPD---GRTLA-SGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 126-163 7.35e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 7.35e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 311315517   126 KSIFTLDGHKDSVNAITFTqPKGQFVTTAGLDGKLRVW 163
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
126-163 7.99e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 311315517  126 KSIFTLDGHKDSVNAITFTqPKGQFVTTAGLDGKLRVW 163
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
302-460 1.94e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 302 SGAFVAVGGPEGQIRIVGLPRISLAAPAQASTSSSGGGAKNKAGGGKQAGAKGGASSAGQAGQILASLQAGSDNVECLSF 381
Cdd:COG2319    7 AALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 311315517 382 SSLPLTLMAAGNvDGSITLFDTAHRfaVRRRIDDAHADeespqAVVKLDFvakeGPGGWLLTSAGYDGVLRRWDTRGGT 460
Cdd:COG2319   87 SPDGRLLASASA-DGTVRLWDLATG--LLLRTLTGHTG-----AVRSVAF----SPDGKTLASGSADGTVRLWDLATGK 153
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-317 5.82e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 5.82e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517  62 NLQNDSVAH-FDEHKDSIFCIAQHPvHQEIIATGGGDdvGYII--DVSAAataqpssdgqpteraglKSIFTLDGHKDSV 138
Cdd:cd00200   79 DLETGECVRtLTGHTSYVSSVAFSP-DGRILSSSSRD--KTIKvwDVETG-----------------KCLTTLRGHTDWV 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 139 NAITFTqPKGQFVTTAGLDGKLRVWqgvpDGKKWKFLAE-AQEVEEINWIAsnPSPDHANVVAlGANDGSVWVYQISTEK 217
Cdd:cd00200  139 NSVAFS-PDGTFVASSSQDGTIKLW----DLRTGKCVATlTGHTGEVNSVA--FSPDGEKLLS-SSSDGTIKLWDLSTGK 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 218 gnELQVLQAyylHTETCTAGTWTPDGSLLATISEDSSLYVWDVfgdaASQGLTATtdsqavigLTGHDERfrveggLYSI 297
Cdd:cd00200  211 --CLGTLRG---HENGVNSVAFSPDGYLLASGSEDGTIRVWDL----RTGECVQT--------LSGHTNS------VTSL 267

                        250       260
                 ....*....|....*....|
gi 311315517 298 GIPPSGAFVAVGGPEGQIRI 317
Cdd:cd00200  268 AWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
68-458 5.75e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.76  E-value: 5.75e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517  68 VAHFDEHKDSIFCIAQHPVHQeIIATGGGDDVGYIIDVSaaataqpssDGQPteraglksIFTLDGHKDSVNAITFTqPK 147
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSPDGK-TLASGSADGTVRLWDLA---------TGKL--------LRTLTGHSGAVTSVAFS-PD 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 148 GQFVTTAGLDGKLRVWQgVPDGKKWKFL-AEAQEVEEINWiasnpSPDHaNVVALGANDGSVWVYQISTekGNELQVLQA 226
Cdd:COG2319  174 GKLLASGSDDGTVRLWD-LATGKLLRTLtGHTGAVRSVAF-----SPDG-KLLASGSADGTVRLWDLAT--GKLLRTLTG 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 227 yylHTETCTAGTWTPDGSLLATISEDSSLYVWDVfgdaasqgltatTDSQAVIGLTGHDerfrveGGLYSIGIPPSGAFV 306
Cdd:COG2319  245 ---HSGSVRSVAFSPDGRLLASGSADGTVRLWDL------------ATGELLRTLTGHS------GGVNSVAFSPDGKLL 303

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 307 AVGGPEGQIRIVGLprislaapaqastsssgggaknkagggkqagakggassagQAGQILASLQAGSDNVECLSFSSLPL 386
Cdd:COG2319  304 ASGSDDGTVRLWDL----------------------------------------ATGKLLRTLTGHTGAVRSVAFSPDGK 343

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 311315517 387 TLmAAGNVDGSITLFDTAHRFAVRRRidDAHADeespqAVVKLDFVAKegpGGWLLtSAGYDGVLRRWDTRG 458
Cdd:COG2319  344 TL-ASGSDDGTVRLWDLATGELLRTL--TGHTG-----AVTSVAFSPD---GRTLA-SGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-455 2.99e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 2.99e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517  67 SVAHFDEHKDSIFCIAQHPvHQEIIATGGGDDVGYIIDVsaaataqpsSDGQPteraglksIFTLDGHKDSVNAITFTqP 146
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDL---------ETGEL--------LRTLKGHTGPVRDVAAS-A 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 147 KGQFVTTAGLDGKLRVWqgvpDGKKWKFLAE-AQEVEEINWIASNPSPDhanVVALGANDGSVWVYQISTekGNELQVLQ 225
Cdd:cd00200   62 DGTYLASGSSDKTIRLW----DLETGECVRTlTGHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVET--GKCLTTLR 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 226 AyylHTETCTAGTWTPDGSLLATISEDSSLYVWDVfgdaASQGLTATtdsqavigLTGHderfrvEGGLYSIGIPPSGAF 305
Cdd:cd00200  133 G---HTDWVNSVAFSPDGTFVASSSQDGTIKLWDL----RTGKCVAT--------LTGH------TGEVNSVAFSPDGEK 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 306 VAVGGPEGQIRIVGLprislaapaqastsssgggaknkagggkqagakggassagQAGQILASLQAGSDNVECLSFSSLP 385
Cdd:cd00200  192 LLSSSSDGTIKLWDL----------------------------------------STGKCLGTLRGHENGVNSVAFSPDG 231

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 386 LtLMAAGNVDGSITLFDTAHrFAVRRRIddahadEESPQAVVKLDFVakegPGGWLLTSAGYDGVLRRWD 455
Cdd:cd00200  232 Y-LLASGSEDGTIRVWDLRT-GECVQTL------SGHTNSVTSLAWS----PDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 127-460 3.29e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 3.29e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 127 SIFTLDGHKDSVNAITFTqPKGQFVTTAGLDGKLRVWQGVPDGKKWKFLAEAQEVEEINWIAsnpspdHANVVALGANDG 206
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA------DGTYLASGSSDK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 207 SVWVYQISTEKgnelqVLQAYYLHTETCTAGTWTPDGSLLATISEDSSLYVWDVfgdaasqgltatTDSQAVIGLTGHde 286
Cdd:cd00200   74 TIRLWDLETGE-----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV------------ETGKCLTTLRGH-- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 287 rfrvEGGLYSIGIPPSGAFVAVGGPEGQIRIVGLprislaapaqastsssgggaknkagggkqagakggassagQAGQIL 366
Cdd:cd00200  135 ----TDWVNSVAFSPDGTFVASSSQDGTIKLWDL----------------------------------------RTGKCV 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 367 ASLQAGSDNVECLSFSSLPLTLMAAGNvDGSITLFDTAHRFAVRRRIddAHadeesPQAVVKLDFvakeGPGGWLLTSAG 446
Cdd:cd00200  171 ATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGKCLGTLR--GH-----ENGVNSVAF----SPDGYLLASGS 238

                        330
                 ....*....|....
gi 311315517 447 YDGVLRRWDTRGGT 460
Cdd:cd00200  239 EDGTIRVWDLRTGE 252
WD40 COG2319
WD40 repeat [General function prediction only];
88-460 3.83e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.28  E-value: 3.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517  88 QEIIATGGGDDVGYIIDVSAAATAQPSSDGQPTER----AGLKSIFTLDGHKDSVNAITFTqPKGQFVTTAGLDGKLRVW 163
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRlwdlATGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLW 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 164 QgVPDGKKWKFLAEAQEveEINWIASnpSPDhANVVALGANDGSVWVYQISTekGNELQVLQAyylHTETCTAGTWTPDG 243
Cdd:COG2319  148 D-LATGKLLRTLTGHSG--AVTSVAF--SPD-GKLLASGSDDGTVRLWDLAT--GKLLRTLTG---HTGAVRSVAFSPDG 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 244 SLLATISEDSSLYVWDVfgdaASQGLTATtdsqavigLTGHDerfrveGGLYSIGIPPSGAFVAVGGPEGQIRIVGLpri 323
Cdd:COG2319  217 KLLASGSADGTVRLWDL----ATGKLLRT--------LTGHS------GSVRSVAFSPDGRLLASGSADGTVRLWDL--- 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 324 slaapaqastsssgggaknkagggkqagakggassagQAGQILASLQAGSDNVECLSFSSLPLTLmAAGNVDGSITLFDT 403
Cdd:COG2319  276 -------------------------------------ATGELLRTLTGHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDL 317

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 311315517 404 AHRFAVRRRidDAHADeespqAVVKLDFvakeGPGGWLLTSAGYDGVLRRWDTRGGT 460
Cdd:COG2319  318 ATGKLLRTL--TGHTG-----AVRSVAF----SPDGKTLASGSDDGTVRLWDLATGE 363
WD40 COG2319
WD40 repeat [General function prediction only];
92-460 1.58e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.74  E-value: 1.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517  92 ATGGGDDVGYIIDVSAAATAQPSSDGQPTERAGLKSIFTLDGHKDSVNAITFTqPKGQFVTTAGLDGKLRVWQGVPDGKK 171
Cdd:COG2319   35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-PDGRLLASASADGTVRLWDLATGLLL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 172 WKFLAEAQEVEEINWiasnpSPDhANVVALGANDGSVWVYQISTekGNELQVLQAyylHTETCTAGTWTPDGSLLATISE 251
Cdd:COG2319  114 RTLTGHTGAVRSVAF-----SPD-GKTLASGSADGTVRLWDLAT--GKLLRTLTG---HSGAVTSVAFSPDGKLLASGSD 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 252 DSSLYVWDVfgdaASQGLTATtdsqavigLTGHDerfrveGGLYSIGIPPSGAFVAVGGPEGQIRIVGLprislaapaqa 331
Cdd:COG2319  183 DGTVRLWDL----ATGKLLRT--------LTGHT------GAVRSVAFSPDGKLLASGSADGTVRLWDL----------- 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 332 stsssgggaknkagggkqagakggassagQAGQILASLQAGSDNVECLSFSSLPLTLmAAGNVDGSITLFDTAHRFAVRR 411
Cdd:COG2319  234 -----------------------------ATGKLLRTLTGHSGSVRSVAFSPDGRLL-ASGSADGTVRLWDLATGELLRT 283

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 311315517 412 RidDAHADeespqAVVKLDFVakegPGGWLLTSAGYDGVLRRWDTRGGT 460
Cdd:COG2319  284 L--TGHSG-----GVNSVAFS----PDGKLLASGSDDGTVRLWDLATGK 321
WD40 COG2319
WD40 repeat [General function prediction only];
104-459 5.83e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.79  E-value: 5.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 104 DVSAAATAQPSSDGQPTERAGLKSIFTLDGHKDSVNAITFTQPKGQFVTTAGLDGKLRVWQGVPdgkkwkfLAEAQEVEE 183
Cdd:COG2319    5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-------ALLATLLGH 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 184 INWIASNPSPDHANVVALGANDGSVWVYQISTekGNELQVLQAyylHTETCTAGTWTPDGSLLATISEDSSLYVWDVfgd 263
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRLWDLAT--GLLLRTLTG---HTGAVRSVAFSPDGKTLASGSADGTVRLWDL--- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 264 aASQGLTATtdsqavigLTGHderfrvEGGLYSIGIPPSGAFVAVGGPEGQIRIVGLprislaapaqastsssgggaknk 343
Cdd:COG2319  150 -ATGKLLRT--------LTGH------SGAVTSVAFSPDGKLLASGSDDGTVRLWDL----------------------- 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 344 agggkqagakggassagQAGQILASLQAGSDNVECLSFSSlPLTLMAAGNVDGSITLFDTAHRFAVRRRidDAHADeesp 423
Cdd:COG2319  192 -----------------ATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTL--TGHSG---- 247

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 311315517 424 qAVVKLDFvakeGPGGWLLTSAGYDGVLRRWDTRGG 459
Cdd:COG2319  248 -SVRSVAF----SPDGRLLASGSADGTVRLWDLATG 278
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 126-163 7.35e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 7.35e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 311315517   126 KSIFTLDGHKDSVNAITFTqPKGQFVTTAGLDGKLRVW 163
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
126-163 7.99e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 311315517  126 KSIFTLDGHKDSVNAITFTqPKGQFVTTAGLDGKLRVW 163
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 222-259 6.70e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 6.70e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 311315517   222 QVLQAYYLHTETCTAGTWTPDGSLLATISEDSSLYVWD 259
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
302-460 1.94e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311315517 302 SGAFVAVGGPEGQIRIVGLPRISLAAPAQASTSSSGGGAKNKAGGGKQAGAKGGASSAGQAGQILASLQAGSDNVECLSF 381
Cdd:COG2319    7 AALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 311315517 382 SSLPLTLMAAGNvDGSITLFDTAHRfaVRRRIDDAHADeespqAVVKLDFvakeGPGGWLLTSAGYDGVLRRWDTRGGT 460
Cdd:COG2319   87 SPDGRLLASASA-DGTVRLWDLATG--LLLRTLTGHTG-----AVRSVAF----SPDGKTLASGSADGTVRLWDLATGK 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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