ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 308165852   4 IDIKNCTKIFKNGMEKIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYS 75
Cdd:cd03255    1 IELKNLSKTYGGGGEKVQALKGVSLSIEKGEFVAIVGPSGSGKSTLLNILGGLDRPTSGEVRVDGTDISKLS 72

ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 308165852   24 NNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYS 75
Cdd:pfam00005   2 KNVSLTLNPGEILALVGPNGAGKSTLLKLIAGLLSPTEGTILLDGQDLTDDE 53

sugar ABC transporter ATP-binding protein;

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 308165852  22 ANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSS--GDIIIDGK 69
Cdd:NF040905  16 ALDDVNLSVREGEIHALCGENGAGKSTLMKVLSGVYPHGSyeGEILFDGE 65

ribosome-associated ATPase/putative transporter RbbA;

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 308165852  22 ANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSG 62
Cdd:NF033858 281 AVDHVSFRIRRGEIFGFLGSNGCGKSTTMKMLTGLLPASEG 321

ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 308165852   4 IDIKNCTKIFKNGMEKIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYS 75
Cdd:cd03255    1 IELKNLSKTYGGGGEKVQALKGVSLSIEKGEFVAIVGPSGSGKSTLLNILGGLDRPTSGEVRVDGTDISKLS 72

ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport and metabolism];

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308165852   1 MTYIDIKNCTKIFKNgmekIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISH 73
Cdd:COG3842    3 MPALELENVSKRYGD----VTALDDVSLSIEPGEFVALLGPSGCGKTTLLRMIAGFETPDSGRILLDGRDVTG 71

ABC-type sugar transport system, ATPase component MalK [Carbohydrate transport and metabolism];

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308165852   1 MTYIDIKNCTKIFKNgmekIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISH 73
Cdd:COG3839    1 MASLELENVSKSYGG----VEALKDIDLDIEDGEFLVLLGPSGCGKSTLLRMIAGLEDPTSGEILIGGRDVTD 69

Cell division ATPase FtsE [Cell cycle control, cell division, chromosome partitioning];

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308165852   4 IDIKNCTKIFKNGMEkiyANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISH 73
Cdd:COG2884    2 IRFENVSKRYPGGRE---ALSDVSLEIEKGEFVFLTGPSGAGKSTLLKLLYGEERPTSGQVLVNGQDLSR 68

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308165852   6 IKNCTKIFKNGmekiYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYS 75
Cdd:cd00267    2 IENLSFRYGGR----TALDNVSLTLKAGEIVALVGPNGSGKSTLLRAIAGLLKPTSGEILIDGKDIAKLP 67

ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308165852   4 IDIKNCTKIFKngmeKIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISH 73
Cdd:cd03259    1 LELKGLSKTYG----SVRALDDLSLTVEPGEFLALLGPSGCGKTTLLRLIAGLERPDSGEILIDGRDVTG 66

Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 308165852   4 IDIKNCTKIFKNGmekIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHY 74
Cdd:cd03292    1 IEFINVTKTYPNG---TAALDGINISISAGEFVFLVGPSGAGKSTLLKLIYKEELPTSGTIRVNGQDVSDL 68

ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308165852   4 IDIKNCTKIFKNGMEKIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYSQ 76
Cdd:cd03257    2 LEVKNLSVSFPTGGGSVKALDDVSFSIKKGETLGLVGESGSGKSTLARAILGLLKPTSGSIIFDGKDLLKLSR 74

First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 308165852  24 NNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYS 75
Cdd:cd03225   18 DDISLTIKKGEFVLIVGPNGSGKSTLLRLLNGLLGPTSGEVLVDGKDLTKLS 69

ATP-binding cassette domain of the lipid transporters, subfamily A; The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency, degenerative retinopathies, and congenital keratinization disorders. The ABCA1 protein is involved in disorders of cholesterol transport and high-density lipoprotein (HDL) biosynthesis. The ABCA4 (ABCR) protein transports vitamin A derivatives in the outer segments of photoreceptor cells, and therefore, performs a crucial step in the visual cycle. The ABCA genes are not present in yeast. However, evolutionary studies of ABCA genes indicate that they arose as transporters that subsequently duplicated and that certain sets of ABCA genes were lost in different eukaryotic lineages.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 308165852   4 IDIKNCTKIFKNGMekIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNI 71
Cdd:cd03263    1 LQIRNLTKTYKKGT--KPAVDDLSLNVYKGEIFGLLGHNGAGKTTTLKMLTGELRPTSGTAYINGYSI 66

ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; This family of ATP-binding proteins belongs to a multi-subunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding protein and one or two integral membrane proteins. Eukaryotic systems of the ABCA subfamily display ABC domains that are quite similar to this family. The ATP-binding domain shows the highest similarity between all members of the ABC transporter family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 308165852   4 IDIKNCTKIFKNGmekiYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNI 71
Cdd:cd03230    1 IEVRNLSKRYGKK----TALDDISLTVEKGEIYGLLGPNGAGKTTLIKIILGLLKPDSGEIKVLGKDI 64

ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 308165852   24 NNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYS 75
Cdd:pfam00005   2 KNVSLTLNPGEILALVGPNGAGKSTLLKLIAGLLSPTEGTILLDGQDLTDDE 53

ATP-binding cassette domain of the histidine and glutamine transporters; HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, respectively. Histidine permease is a multi-subunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP has properties intermediate between those of integral and peripheral membrane proteins and is accessible from both sides of the membrane, presumably by its interaction with HisQ and HisM. The two HisP subunits form a homodimer within the complex. The domain structure of the amino acid uptake systems is typical for prokaryotic extracellular solute binding protein-dependent uptake systems. All of the amino acid uptake systems also have at least one, and in a few cases, two extracellular solute binding proteins located in the periplasm of Gram-negative bacteria, or attached to the cell membrane of Gram-positive bacteria. The best-studied member of the PAAT (polar amino acid transport) family is the HisJQMP system of S. typhimurium, where HisJ is the extracellular solute binding proteins and HisP is the ABC protein.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308165852   4 IDIKNCTKIFKNgmekIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISH 73
Cdd:cd03262    1 IEIKNLHKSFGD----FHVLKGIDLTVKKGEVVVIIGPSGSGKSTLLRCINLLEEPDSGTIIIDGLKLTD 66

ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and metabolism];

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 308165852   4 IDIKNCTKIFKNgmekIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGK 69
Cdd:COG3845    6 LELRGITKRFGG----VVANDDVSLTVRPGEIHALLGENGAGKSTLMKILYGLYQPDSGEILIDGK 67

ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones];

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308165852   4 IDIKNCTKIFK-NGMEKIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYS 75
Cdd:COG1123  261 LEVRNLSKRYPvRGKGGVRAVDDVSLTLRRGETLGLVGESGSGKSTLARLLLGLLRPTSGSILFDGKDLTKLS 333

Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport and catabolism];

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 308165852  26 INFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNIS 72
Cdd:COG4181   31 ISLEVEAGESVAIVGASGSGKSTLLGLLAGLDRPTSGTVRLAGQDLF 77

ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 308165852  24 NNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYS 75
Cdd:COG2274  492 DNISLTIKPGERVAIVGRSGSGKSTLLKLLLGLYEPTSGRILIDGIDLRQID 543

ferric ABC transporter ATP-binding protein;

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308165852   3 YIDIKNCTKIFKNGMekiyANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYS 75
Cdd:PRK11432   6 FVVLKNITKRFGSNT----VIDNLNLTIKQGTMVTLLGPSGCGKTTVLRLVAGLEKPTEGQIFIDGEDVTHRS 74

ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall/membrane/envelope biogenesis];

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308165852   4 IDIKNCTKIFknGMEKIYanNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYSQ 76
Cdd:COG1127    6 IEVRNLTKSF--GDRVVL--DGVSLDVPRGEILAIIGGSGSGKSVLLKLIIGLLRPDSGEILVDGQDITGLSE 74

ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 308165852  14 KNGMEKIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGK 69
Cdd:COG1134   33 RTRREEFWALKDVSFEVERGESVGIIGRNGAGKSTLLKLIAGILEPTSGRVEVNGR 88

lipoprotein-releasing ABC transporter ATP-binding protein LolD;

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 308165852   8 NCTKIFKNGMEKIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYS 75
Cdd:PRK11629  10 NLCKRYQEGSVQTDVLHNVSFSIGEGEMMAIVGSSGSGKSTLLHLLGGLDTPTSGDVIFNGQPMSKLS 77

ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporters is the obligatory coupling of ATP hydrolysis to substrate translocation. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308165852   4 IDIKNCTKIF-----------KNGMEK--IY-------ANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGD 63
Cdd:cd03294    1 IKIKGLYKIFgknpqkafkllAKGKSKeeILkktgqtvGVNDVSLDVREGEIFVIMGLSGSGKSTLLRCINRLIEPTSGK 80

                 ....*....
gi 308165852  64 IIIDGKNIS 72
Cdd:cd03294   81 VLIDGQDIA 89

Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and metabolism, General function prediction only];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 308165852  24 NNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYS 75
Cdd:COG1122   18 DDVSLSIEKGEFVAIIGPNGSGKSTLLRLLNGLLKPTSGEVLVDGKDITKKN 69

ATP-binding cassette component of polysaccharide transport system; The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and teichoic acids have been shown to be exported by ABC transporters. A typical system is made of a conserved integral membrane and an ABC. In addition to these proteins, capsular polysaccharide exporter systems require two 'accessory' proteins to perform their function: a periplasmic (E.coli) or a lipid-anchored outer membrane protein called OMA (Neisseria meningitidis and Haemophilus influenza) and a cytoplasmic membrane protein MPA2.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 308165852  11 KIFKNGMEKIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGK 69
Cdd:cd03220   26 LGRKGEVGEFWALKDVSFEVPRGERIGLIGRNGAGKSTLLRLLAGIYPPDSGTVTVRGR 84

ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 308165852  24 NNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYS 75
Cdd:COG4559   18 DDVSLTLRPGELTAIIGPNGAGKSTLLKLLTGELTPSSGEVRLNGRPLAAWS 69

ATP-binding cassette domain of the osmoprotectant transporter; OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition, to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 308165852   4 IDIKNCTKIFKNGMEkiyANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHY 74
Cdd:cd03295    1 IEFENVTKRYGGGKK---AVNNLNLEIAKGEFLVLIGPSGSGKTTTMKMINRLIEPTSGEIFIDGEDIREQ 68

macrolide ABC transporter ATP-binding protein/permease MacB;

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 308165852   4 IDIKNCTKIFKNGMEKIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNIS 72
Cdd:PRK10535   5 LELKDIRRSYPSGEEQVEVLKGISLDIYAGEMVAIVGASGSGKSTLMNILGCLDKPTSGTYRVAGQDVA 73

ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 308165852  22 ANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISH 73
Cdd:COG1129   19 ALDGVSLELRPGEVHALLGENGAGKSTLMKILSGVYQPDSGEILLDGEPVRF 70

energy-coupling factor transporter ATPase;

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 308165852   4 IDIKNCTKIFKNGM--EKIyANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNIS 72
Cdd:PRK13637   3 IKIENLTHIYMEGTpfEKK-ALDNVNIEIEDGEFVGLIGHTGSGKSTLIQHLNGLLKPTSGKIIIDGVDIT 72

ABC-type branched-chain amino acid transport system, ATPase component LivF [Amino acid transport and metabolism];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 308165852  24 NNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISH 73
Cdd:COG0410   20 HGVSLEVEEGEIVALLGRNGAGKTTLLKAISGLLPPRSGSIRFDGEDITG 69

cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 308165852  24 NNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYSQ 76
Cdd:PRK11160 357 KGLSLQIKAGEKVALLGRTGCGKSTLLQLLTRAWDPQQGEILLNGQPIADYSE 409

ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only];

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 308165852   4 IDIKNCTKIFknGMEKIYanNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIdGKN--ISHYSQ 76
Cdd:COG0488  316 LELEGLSKSY--GDKTLL--DDLSLRIDRGDRIGLIGPNGAGKSTLLKLLAGELEPDSGTVKL-GETvkIGYFDQ 385

ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 308165852   4 IDIKNCTkiFKNGMEKIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYS 75
Cdd:cd03251    1 VEFKNVT--FRYPGDGPPVLRDISLDIPAGETVALVGPSGSGKSTLVNLIPRFYDVDSGRILIDGHDVRDYT 70

putative ABC transporter ATP-binding protein YbbL; Provisional

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308165852  13 FKNGMEKIYanNNINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYS 75
Cdd:PRK10247  15 YLAGDAKIL--NNISFSLRAGEFKLITGPSGCGKSTLLKIVASLISPTSGTLLFEGEDISTLK 75

ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virulence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and lipid export. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains each composed of six transmembrane (TM) helices and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 308165852  25 NINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISHYS 75
Cdd:cd03254   21 DINFSIKPGETVAIVGPTGAGKTTLINLLMRFYDPQKGQILIDGIDIRDIS 71

ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism];

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 308165852  25 NINFVINRGELVIILGSSGAGKSTLLNILGGMENCSSGDIIIDGKNISH 73
Cdd:COG1121   24 DVSLTIPPGEFVAIVGPNGAGKSTLLKAILGLLPPTSGTVRLFGKPPRR 72

ABC-type cobalamin transport system, ATPase component BtuD [Coenzyme transport and metabolism];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 308165852  26 INFVINRGELVIILGSSGAGKSTLLNILGGMENcSSGDIIIDGKNISHYS 75
Cdd:COG4138   15 ISAQVNAGELIHLIGPNGAGKSTLLARMAGLLP-GQGEILLNGRPLSDWS 63

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 308165852   4 IDIKNCTKIFKNGMEKIYANNNINFVINRGELVIILGSSGAGKSTLLNILGGME---NCSSGDIIIDGKNISHYSQ 76
Cdd:COG0444    2 LEVRNLKVYFPTRRGVVKAVDGVSFDVRRGETLGLVGESGSGKSTLARAILGLLpppGITSGEILFDGEDLLKLSE 77