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Conserved domains on  [gi|300155339|gb|EFJ21971|]
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hypothetical protein SELMODRAFT_105976 [Selaginella moellendorffii]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
245-427 4.06e-26

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 4.06e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 245 SPSGpTRLMTSNNDAVVRVFDAETFAVLGRF-CYCWPVNHTSVSPDCRSIVVVGDNTEGLLADASSGKVIATLKGHLDYS 323
Cdd:COG2319  129 SPDG-KTLASGSADGTVRLWDLATGKLLRTLtGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 324 FASAWHPDGRIFATGNQDTTCRLWDVRNlSSSLAILKGRLGAIRSLRFTEDGRFMAMAEPADFVHVFDTRQDFMQSQEID 403
Cdd:COG2319  208 RSVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        170       180
                 ....*....|....*....|....
gi 300155339 404 LFGEIAGISFSPDTEALYIGVADR 427
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDG 310
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
245-427 4.06e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 4.06e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 245 SPSGpTRLMTSNNDAVVRVFDAETFAVLGRF-CYCWPVNHTSVSPDCRSIVVVGDNTEGLLADASSGKVIATLKGHLDYS 323
Cdd:COG2319  129 SPDG-KTLASGSADGTVRLWDLATGKLLRTLtGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 324 FASAWHPDGRIFATGNQDTTCRLWDVRNlSSSLAILKGRLGAIRSLRFTEDGRFMAMAEPADFVHVFDTRQDFMQSQEID 403
Cdd:COG2319  208 RSVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        170       180
                 ....*....|....*....|....
gi 300155339 404 LFGEIAGISFSPDTEALYIGVADR 427
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDG 310
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 245-427 1.05e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 1.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 245 SPSGPtRLMTSNNDAVVRVFDAETFAVLGRFCycwpvNHT------SVSPDCRSIVVVGDNTEGLLADASSGKVIATLKG 318
Cdd:cd00200   18 SPDGK-LLATGSGDGTIKVWDLETGELLRTLK-----GHTgpvrdvAASADGTYLASGSSDKTIRLWDLETGECVRTLTG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 319 HLDYSFASAWHPDGRIFATGNQDTTCRLWDVRNlSSSLAILKGRLGAIRSLRFTEDGRFMAMAEPADFVHVFDTRqdfmQ 398
Cdd:cd00200   92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR----T 166

                        170       180       190
                 ....*....|....*....|....*....|...
gi 300155339 399 SQEIDLF----GEIAGISFSPDTEALYIGVADR 427
Cdd:cd00200  167 GKCVATLtghtGEVNSVAFSPDGEKLLSSSSDG 199
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 309-348 6.29e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 6.29e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 300155339   309 SGKVIATLKGHLDYSFASAWHPDGRIFATGNQDTTCRLWD 348
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
310-348 2.38e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.38e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 300155339  310 GKVIATLKGHLDYSFASAWHPDGRIFATGNQDTTCRLWD 348
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
245-427 4.06e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 4.06e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 245 SPSGpTRLMTSNNDAVVRVFDAETFAVLGRF-CYCWPVNHTSVSPDCRSIVVVGDNTEGLLADASSGKVIATLKGHLDYS 323
Cdd:COG2319  129 SPDG-KTLASGSADGTVRLWDLATGKLLRTLtGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 324 FASAWHPDGRIFATGNQDTTCRLWDVRNlSSSLAILKGRLGAIRSLRFTEDGRFMAMAEPADFVHVFDTRQDFMQSQEID 403
Cdd:COG2319  208 RSVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        170       180
                 ....*....|....*....|....
gi 300155339 404 LFGEIAGISFSPDTEALYIGVADR 427
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDG 310
WD40 COG2319
WD40 repeat [General function prediction only];
245-427 2.91e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 2.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 245 SPSGpTRLMTSNNDAVVRVFDAETFAVLGRF-CYCWPVNHTSVSPDCRSIVVVGDNTEGLLADASSGKVIATLKGHLDYS 323
Cdd:COG2319  213 SPDG-KLLASGSADGTVRLWDLATGKLLRTLtGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGV 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 324 FASAWHPDGRIFATGNQDTTCRLWDVRNlSSSLAILKGRLGAIRSLRFTEDGRFMAMAEPADFVHVFDTRqdfmQSQEID 403
Cdd:COG2319  292 NSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA----TGELLR 366

                        170       180
                 ....*....|....*....|....*...
gi 300155339 404 LF----GEIAGISFSPDTEALYIGVADR 427
Cdd:COG2319  367 TLtghtGAVTSVAFSPDGRTLASGSADG 394
WD40 COG2319
WD40 repeat [General function prediction only];
247-427 4.07e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.76  E-value: 4.07e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 247 SGPTRLMTSNNDAVVRVFDAETFAVLGRF-CYCWPVNHTSVSPDCRSIVVVGDNTEGLLADASSGKVIATLKGHLDYSFA 325
Cdd:COG2319   88 PDGRLLASASADGTVRLWDLATGLLLRTLtGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 326 SAWHPDGRIFATGNQDTTCRLWDVRNlSSSLAILKGRLGAIRSLRFTEDGRFMAMAEPADFVHVFDTRqdfmQSQEIDLF 405
Cdd:COG2319  168 VAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA----TGKLLRTL 242

                        170       180
                 ....*....|....*....|....*.
gi 300155339 406 ----GEIAGISFSPDTEALYIGVADR 427
Cdd:COG2319  243 tghsGSVRSVAFSPDGRLLASGSADG 268
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 245-427 1.05e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 1.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 245 SPSGPtRLMTSNNDAVVRVFDAETFAVLGRFCycwpvNHT------SVSPDCRSIVVVGDNTEGLLADASSGKVIATLKG 318
Cdd:cd00200   18 SPDGK-LLATGSGDGTIKVWDLETGELLRTLK-----GHTgpvrdvAASADGTYLASGSSDKTIRLWDLETGECVRTLTG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 319 HLDYSFASAWHPDGRIFATGNQDTTCRLWDVRNlSSSLAILKGRLGAIRSLRFTEDGRFMAMAEPADFVHVFDTRqdfmQ 398
Cdd:cd00200   92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR----T 166

                        170       180       190
                 ....*....|....*....|....*....|...
gi 300155339 399 SQEIDLF----GEIAGISFSPDTEALYIGVADR 427
Cdd:cd00200  167 GKCVATLtghtGEVNSVAFSPDGEKLLSSSSDG 199
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 245-429 4.64e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 4.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 245 SPSGPTRLmTSNNDAVVRVFDAETfavlGRFCYCW-----PVNHTSVSPDCRSIVVVGDNTEGLLADASSGKVIATLKGH 319
Cdd:cd00200  102 SPDGRILS-SSSRDKTIKVWDVET----GKCLTTLrghtdWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGH 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 320 LDYSFASAWHPDGRIFATGNQDTTCRLWDVRNlSSSLAILKGRLGAIRSLRFTEDGRFMAMAEPADFVHVFDTR-QDFMQ 398
Cdd:cd00200  177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST-GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRtGECVQ 255

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 300155339 399 SqeidLFG---EIAGISFSPDTEALYIGVAD---RIY 429
Cdd:cd00200  256 T----LSGhtnSVTSLAWSPDGKRLASGSADgtiRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
245-427 7.73e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 7.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 245 SPSGPTRLMTSNNDAVVRVFDAETFAVLGRFCYCWPVNHTSVSPDCRSIVVVGDNTEGLLADASSGKVIATLKGHLDYSF 324
Cdd:COG2319   45 SPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVR 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 325 ASAWHPDGRIFATGNQDTTCRLWDVRNlSSSLAILKGRLGAIRSLRFTEDGRFMAMAEPADFVHVFDTRQDfmqsQEIDL 404
Cdd:COG2319  125 SVAFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG----KLLRT 199

                        170       180
                 ....*....|....*....|....*..
gi 300155339 405 F----GEIAGISFSPDTEALYIGVADR 427
Cdd:COG2319  200 LtghtGAVRSVAFSPDGKLLASGSADG 226
WD40 COG2319
WD40 repeat [General function prediction only];
229-351 3.76e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 3.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 229 ITHDENAItNAIEIynSPSGpTRLMTSNNDAVVRVFDAETFAVLGRFC-YCWPVNHTSVSPDCRSIVVVGDNTEGLLADA 307
Cdd:COG2319  284 LTGHSGGV-NSVAF--SPDG-KLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 300155339 308 SSGKVIATLKGHLDYSFASAWHPDGRIFATGNQDTTCRLWDVRN 351
Cdd:COG2319  360 ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 245-391 1.37e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.99  E-value: 1.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 245 SPSGpTRLMTSNNDAVVRVFDAETFAVLGRFC--YCWpVNHTSVSPDCRSIVVVGDNTEGLLADASSGKVIATLKGHLDY 322
Cdd:cd00200  144 SPDG-TFVASSSQDGTIKLWDLRTGKCVATLTghTGE-VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG 221

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300155339 323 SFASAWHPDGRIFATGNQDTTCRLWDVRNLSSsLAILKGRLGAIRSLRFTEDGRFMAMAEPADFVHVFD 391
Cdd:cd00200  222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
245-427 4.80e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.33  E-value: 4.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 245 SPSGPTRLMTSNNDAVVRVFDAETFAVLGRFCYCWPVNHTSVSPDCRSIVVVGDNTEGLLADASSGKVIATLKGHLDYSF 324
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 325 ASAWHPDGRIFATGNQDTTCRLWDVRNlSSSLAILKGRLGAIRSLRFTEDGRFMAMAEPADFVHVFDTRqdfmQSQEIDL 404
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA----TGKLLRT 157

                        170       180
                 ....*....|....*....|....*..
gi 300155339 405 F----GEIAGISFSPDTEALYIGVADR 427
Cdd:COG2319  158 LtghsGAVTSVAFSPDGKLLASGSDDG 184
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 280-427 1.87e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.42  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 280 PVNHTSVSPDCRSIVVVGDNTEGLLADASSGKVIATLKGHLDYSFASAWHPDGRIFATGNQDTTCRLWDVRNlSSSLAIL 359
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET-GECVRTL 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300155339 360 KGRLGAIRSLRFTEDGRFMAMAEPADFVHVFDTRqDFMQSQEIDLF-GEIAGISFSPDTEALYIGVADR 427
Cdd:cd00200   90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-TGKCLTTLRGHtDWVNSVAFSPDGTFVASSSQDG 157
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 313-427 2.44e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 2.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 313 IATLKGHLDYSFASAWHPDGRIFATGNQDTTCRLWDVRNlSSSLAILKGRLGAIRSLRFTEDGRFMAMAEPADFVHVFDT 392
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET-GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 300155339 393 RQDFMQSQEIDLFGEIAGISFSPDTEALYIGVADR 427
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDK 115
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 309-348 6.29e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 6.29e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 300155339   309 SGKVIATLKGHLDYSFASAWHPDGRIFATGNQDTTCRLWD 348
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
310-348 2.38e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.38e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 300155339  310 GKVIATLKGHLDYSFASAWHPDGRIFATGNQDTTCRLWD 348
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
245-345 2.36e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.37  E-value: 2.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339 245 SPSGPTRLMTSNNDAVVRVFDAETFAVLGRFCYCWPVNHTSVSPDCRSIVVVGDNTEGLLA-----DASSGKVIATLKGH 319
Cdd:COG3391  118 DPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNTVSVivsviDTATGKVVATIPVG 197

                         90       100
                 ....*....|....*....|....*...
gi 300155339 320 lDYSFASAWHPDGR-IFAT-GNQDTTCR 345
Cdd:COG3391  198 -GGPVGVAVSPDGRrLYVAnRGSNTSNG 224
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 286-395 8.55e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.95  E-value: 8.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300155339  286 VSPDCRSIVVVGDNTEGLLADASSGKV--IAT-LKGHLDYSFasAWHPDGRIFA----TGNQDTTCRLWDVRNLsSSLAI 358
Cdd:COG4946   396 WSPDGKKIAFTDNRGRLWVVDLASGKVrkVDTdGYGDGISDL--AWSPDSKWLAyskpGPNQLSQIFLYDVETG-KTVQL 472

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 300155339  359 LKGRLGAIrSLRFTEDGRFMAMA-----EPA----DFVHVFDTRQD 395
Cdd:COG4946   473 TDGRYDDG-SPAFSPDGKYLYFLssrdfNPTygdlDFDLAFPRTTR 517
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 327-351 4.98e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.10  E-value: 4.98e-03
                          10        20
                  ....*....|....*....|....*
gi 300155339  327 AWHPDGRIFATGNQDTTCRLWDVRN 351
Cdd:pfam12894  45 AWRPDGKLLAVGYSDGTVRLLDAEN 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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