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Conserved domains on  [gi|297339996|gb|EFH70413|]
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stomatal cytokinesis-defective 1 [Arabidopsis lyrata subsp. lyrata]

Protein Classification

DENN and WD40 domain-containing protein( domain architecture ID 10655396)

protein containing domains uDENN, DENN, dDENN, and WD40

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 835-1131 1.08e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 209.50  E-value: 1.08e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  835 NVRVLKGHGGAVTALHSVtrrevcdlvgdrEDAGFFISGSTDCLVKIWDpsLRGSELRATLKGHTGTVRAI--SSDRGKI 912
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFS------------PDGKLLATGSGDGTIKVWD--LETGELLRTLKGHTGPVRDVaaSADGTYL 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  913 VSGSDDQSVIVWDKQTTQLLEELKGHDSQVSCVKMLSGERVLTAAH-DGTVKMWDVRTDMCVATVGRCSSAILSLEYDDS 991
Cdd:cd00200    67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  992 TGILAAAGRDTVANIWDIRSGKQMHKLKGHTKWIRSIRMVED--TLITGSDDWTARVWSVSRGSCDAVLACHAGPVQSVE 1069
Cdd:cd00200   147 GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 297339996 1070 YSPFDKGIITGSADGLLRFWENDDGgiKCVKNITLHSSSILSI--NAGENWLGIGAADNSMSLF 1131
Cdd:cd00200   227 FSPDGYLLASGSEDGTIRVWDLRTG--ECVQTLSGHTNSVTSLawSPDGKRLASGSADGTIRIW 288
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 123-304 1.44e-56

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214823  Cd Length: 183  Bit Score: 193.57  E-value: 1.44e-56
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996    123 ADKCICLVSHAPNFRVLRNSLEEIFVLCFSSegSCKPLWDIITYMvsNVPLPTPGKDRVLFAVENCLLSV-EAPPEDSLP 201
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSS--SNLPLELLISLL--LYPVPPPGGSLVLVSLGPGDLIElQRPLDSSLP 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996    202 QADISLQPLVQCLDVDNLIKLFTSVLVERRILIRSNKYSLLTLVSESICHMIYPFRWQQVYIPLLFFSGVDYIDAPTPYM 281
Cdd:smart00799   77 LIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFI 156

                           170       180
                    ....*....|....*....|....*
gi 297339996    282 MGLHSDVDTSY--LAMEGVVVVDLD 304
Cdd:smart00799  157 IGVHSSYFEEVkeLPDEDVVVVDLD 181
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 1-103 4.45e-16

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 74.29  E-value: 4.45e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996      1 MGRIFEYFVVCGLGPEIrtvdgdlgfHGMQTFYLPALLDQFPPTDQSPYPAPPPQLPTCvLPAGVEFhssgfVSSDPASF 80
Cdd:smart00800    1 PSRLFDYFVVVGLDSDT---------GPLGRSYKPEILQRYPEKDFEDFPLPDSIPLFC-FPEGLDF-----VTQTSSKD 65

                            90       100
                    ....*....|....*....|...
gi 297339996     81 PRSYPIVLTEGDGSKIFVSCIAF 103
Cdd:smart00800   66 PQFFSFVLTDIDGSRRYGFCLRF 88
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 366-430 6.00e-12

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 61.92  E-value: 6.00e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 297339996    366 DLQLRVIFLKFFASILGGYRNFIENK--------VFSSDAFLKRRSRTTnqppEPMLVQFLGSFAFLDYLERR 430
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRELrkepgpviTFDKESFLKSRPSSE----RPFLSKFLETQMFSQFIEER 69
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 835-1131 1.08e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 209.50  E-value: 1.08e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  835 NVRVLKGHGGAVTALHSVtrrevcdlvgdrEDAGFFISGSTDCLVKIWDpsLRGSELRATLKGHTGTVRAI--SSDRGKI 912
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFS------------PDGKLLATGSGDGTIKVWD--LETGELLRTLKGHTGPVRDVaaSADGTYL 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  913 VSGSDDQSVIVWDKQTTQLLEELKGHDSQVSCVKMLSGERVLTAAH-DGTVKMWDVRTDMCVATVGRCSSAILSLEYDDS 991
Cdd:cd00200    67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  992 TGILAAAGRDTVANIWDIRSGKQMHKLKGHTKWIRSIRMVED--TLITGSDDWTARVWSVSRGSCDAVLACHAGPVQSVE 1069
Cdd:cd00200   147 GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 297339996 1070 YSPFDKGIITGSADGLLRFWENDDGgiKCVKNITLHSSSILSI--NAGENWLGIGAADNSMSLF 1131
Cdd:cd00200   227 FSPDGYLLASGSEDGTIRVWDLRTG--ECVQTLSGHTNSVTSLawSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
769-1184 4.05e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 209.38  E-value: 4.05e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  769 PSPRPKDVSVSDETQQPSEASGRSWVQSMFSRDTASRANSFSRVRKWVSDNASSDIAAAAQKKIQTNVRVLKGHGGAVTA 848
Cdd:COG2319     4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  849 lhsvtrrevcdlVGDREDAGFFISGSTDCLVKIWDpsLRGSELRATLKGHTGTVR--AISSDRGKIVSGSDDQSVIVWDK 926
Cdd:COG2319    84 ------------VAFSPDGRLLASASADGTVRLWD--LATGLLLRTLTGHTGAVRsvAFSPDGKTLASGSADGTVRLWDL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  927 QTTQLLEELKGHDSQVSCVKMLS-GERVLTAAHDGTVKMWDVRTDMCVATVGRCSSAILSLEYDDSTGILAAAGRDTVAN 1005
Cdd:COG2319   150 ATGKLLRTLTGHSGAVTSVAFSPdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996 1006 IWDIRSGKQMHKLKGHTKWIRSIRMVED--TLITGSDDWTARVWSVSRGSCDAVLACHAGPVQSVEYSPFDKGIITGSAD 1083
Cdd:COG2319   230 LWDLATGKLLRTLTGHSGSVRSVAFSPDgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996 1084 GLLRFWENDDGgiKCVKNITLHSSSILSI--NAGENWLGIGAADNSMSLFHrpssagtkVSGWQLYRVPQRTAAVVRCVA 1161
Cdd:COG2319   310 GTVRLWDLATG--KLLRTLTGHTGAVRSVafSPDGKTLASGSDDGTVRLWD--------LATGELLRTLTGHTGAVTSVA 379

                         410       420
                  ....*....|....*....|...
gi 297339996 1162 SDLERKRICSGGRNGVLRLWDAT 1184
Cdd:COG2319   380 FSPDGRTLASGSADGTVRLWDLA 402
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 123-304 1.44e-56

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 193.57  E-value: 1.44e-56
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996    123 ADKCICLVSHAPNFRVLRNSLEEIFVLCFSSegSCKPLWDIITYMvsNVPLPTPGKDRVLFAVENCLLSV-EAPPEDSLP 201
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSS--SNLPLELLISLL--LYPVPPPGGSLVLVSLGPGDLIElQRPLDSSLP 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996    202 QADISLQPLVQCLDVDNLIKLFTSVLVERRILIRSNKYSLLTLVSESICHMIYPFRWQQVYIPLLFFSGVDYIDAPTPYM 281
Cdd:smart00799   77 LIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFI 156

                           170       180
                    ....*....|....*....|....*
gi 297339996    282 MGLHSDVDTSY--LAMEGVVVVDLD 304
Cdd:smart00799  157 IGVHSSYFEEVkeLPDEDVVVVDLD 181
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 122-304 9.11e-47

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 165.82  E-value: 9.11e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996   122 YADKCICLVSHAPNFRVLRNSLEEIFVLCFSSegsckPLWDII-TYMVS---NVPLPTPGKDRVLFAV---ENCLLsveA 194
Cdd:pfam02141    1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTIS-----PLPNPIeRFIANllyEVPFPPPGRTQKLKPLggtEPILL---Q 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996   195 PPEDS-LPQADISLQPLVQCLDVDNLIKLFTSVLVERRILIRSNKYSLLTLVSESICHMIYPFRWQQVYIPLLFFSGVDY 273
Cdd:pfam02141   73 RPEDSeLPLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDV 152

                          170       180       190
                   ....*....|....*....|....*....|..
gi 297339996   274 IDAPTPYMMGLHSDV-DTSYLAMEGVVVVDLD 304
Cdd:pfam02141  153 LSAPTPFIIGVHSRYfDLLEDPLDDVVLVDLD 184
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 1-103 4.45e-16

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 74.29  E-value: 4.45e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996      1 MGRIFEYFVVCGLGPEIrtvdgdlgfHGMQTFYLPALLDQFPPTDQSPYPAPPPQLPTCvLPAGVEFhssgfVSSDPASF 80
Cdd:smart00800    1 PSRLFDYFVVVGLDSDT---------GPLGRSYKPEILQRYPEKDFEDFPLPDSIPLFC-FPEGLDF-----VTQTSSKD 65

                            90       100
                    ....*....|....*....|...
gi 297339996     81 PRSYPIVLTEGDGSKIFVSCIAF 103
Cdd:smart00800   66 PQFFSFVLTDIDGSRRYGFCLRF 88
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 366-430 6.00e-12

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 61.92  E-value: 6.00e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 297339996    366 DLQLRVIFLKFFASILGGYRNFIENK--------VFSSDAFLKRRSRTTnqppEPMLVQFLGSFAFLDYLERR 430
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRELrkepgpviTFDKESFLKSRPSSE----RPFLSKFLETQMFSQFIEER 69
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 909-1050 1.59e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.49  E-value: 1.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  909 RGKIVSGSDDQSVIVWDKQTTQLLEELKGHDSQVSCVKMLSGERVLTA--AHDGTVKMWDVRTDMCVATVgRCSSAILSL 986
Cdd:PLN00181  545 KSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAsgSDDGSVKLWSINQGVSIGTI-KTKANICCV 623

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 297339996  987 EYDDSTG-ILAAAGRDTVANIWDIRSGK-QMHKLKGHTKWIRSIRMVE-DTLITGSDDWTARVWSVS 1050
Cdd:PLN00181  624 QFPSESGrSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDsSTLVSSSTDNTLKLWDLS 690
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 35-101 6.30e-06

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 44.52  E-value: 6.30e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 297339996    35 PALLDQFPPTDQSPYPAPPPQLPTCvLPAGVEFHSSgfvssdpaSFPRSYPIVLTEGDGSKIFVSCI 101
Cdd:pfam03456    1 PEVLDRYPEDDWSDPPLPDGIPMFC-FPEGLETLSS--------REPTFFSFVLTDEDGSRLYGACL 58
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 890-925 2.01e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 2.01e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 297339996    890 ELRATLKGHTGTVRAI--SSDRGKIVSGSDDQSVIVWD 925
Cdd:smart00320    3 ELLKTLKGHTGPVTSVafSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
889-925 6.96e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 6.96e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 297339996   889 SELRATLKGHTGTVRAI--SSDRGKIVSGSDDQSVIVWD 925
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLafSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 835-1131 1.08e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 209.50  E-value: 1.08e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  835 NVRVLKGHGGAVTALHSVtrrevcdlvgdrEDAGFFISGSTDCLVKIWDpsLRGSELRATLKGHTGTVRAI--SSDRGKI 912
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFS------------PDGKLLATGSGDGTIKVWD--LETGELLRTLKGHTGPVRDVaaSADGTYL 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  913 VSGSDDQSVIVWDKQTTQLLEELKGHDSQVSCVKMLSGERVLTAAH-DGTVKMWDVRTDMCVATVGRCSSAILSLEYDDS 991
Cdd:cd00200    67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  992 TGILAAAGRDTVANIWDIRSGKQMHKLKGHTKWIRSIRMVED--TLITGSDDWTARVWSVSRGSCDAVLACHAGPVQSVE 1069
Cdd:cd00200   147 GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 297339996 1070 YSPFDKGIITGSADGLLRFWENDDGgiKCVKNITLHSSSILSI--NAGENWLGIGAADNSMSLF 1131
Cdd:cd00200   227 FSPDGYLLASGSEDGTIRVWDLRTG--ECVQTLSGHTNSVTSLawSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
769-1184 4.05e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 209.38  E-value: 4.05e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  769 PSPRPKDVSVSDETQQPSEASGRSWVQSMFSRDTASRANSFSRVRKWVSDNASSDIAAAAQKKIQTNVRVLKGHGGAVTA 848
Cdd:COG2319     4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  849 lhsvtrrevcdlVGDREDAGFFISGSTDCLVKIWDpsLRGSELRATLKGHTGTVR--AISSDRGKIVSGSDDQSVIVWDK 926
Cdd:COG2319    84 ------------VAFSPDGRLLASASADGTVRLWD--LATGLLLRTLTGHTGAVRsvAFSPDGKTLASGSADGTVRLWDL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  927 QTTQLLEELKGHDSQVSCVKMLS-GERVLTAAHDGTVKMWDVRTDMCVATVGRCSSAILSLEYDDSTGILAAAGRDTVAN 1005
Cdd:COG2319   150 ATGKLLRTLTGHSGAVTSVAFSPdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996 1006 IWDIRSGKQMHKLKGHTKWIRSIRMVED--TLITGSDDWTARVWSVSRGSCDAVLACHAGPVQSVEYSPFDKGIITGSAD 1083
Cdd:COG2319   230 LWDLATGKLLRTLTGHSGSVRSVAFSPDgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996 1084 GLLRFWENDDGgiKCVKNITLHSSSILSI--NAGENWLGIGAADNSMSLFHrpssagtkVSGWQLYRVPQRTAAVVRCVA 1161
Cdd:COG2319   310 GTVRLWDLATG--KLLRTLTGHTGAVRSVafSPDGKTLASGSDDGTVRLWD--------LATGELLRTLTGHTGAVTSVA 379

                         410       420
                  ....*....|....*....|...
gi 297339996 1162 SDLERKRICSGGRNGVLRLWDAT 1184
Cdd:COG2319   380 FSPDGRTLASGSADGTVRLWDLA 402
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 123-304 1.44e-56

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 193.57  E-value: 1.44e-56
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996    123 ADKCICLVSHAPNFRVLRNSLEEIFVLCFSSegSCKPLWDIITYMvsNVPLPTPGKDRVLFAVENCLLSV-EAPPEDSLP 201
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSS--SNLPLELLISLL--LYPVPPPGGSLVLVSLGPGDLIElQRPLDSSLP 76

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996    202 QADISLQPLVQCLDVDNLIKLFTSVLVERRILIRSNKYSLLTLVSESICHMIYPFRWQQVYIPLLFFSGVDYIDAPTPYM 281
Cdd:smart00799   77 LIDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFI 156

                           170       180
                    ....*....|....*....|....*
gi 297339996    282 MGLHSDVDTSY--LAMEGVVVVDLD 304
Cdd:smart00799  157 IGVHSSYFEEVkeLPDEDVVVVDLD 181
WD40 COG2319
WD40 repeat [General function prediction only];
761-1127 3.02e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 200.91  E-value: 3.02e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  761 QQAISSGLPSPRPKDVSVSDETQQPSEASGRSWVQSMFSRDTASRANSFSRVRKWVSDNASSDIAAAAQKKIQTNVRVLK 840
Cdd:COG2319    38 AVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  841 GHGGAVTALhSVTRrevcdlvgdreDAGFFISGSTDCLVKIWDpsLRGSELRATLKGHTGTVR--AISSDRGKIVSGSDD 918
Cdd:COG2319   118 GHTGAVRSV-AFSP-----------DGKTLASGSADGTVRLWD--LATGKLLRTLTGHSGAVTsvAFSPDGKLLASGSDD 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  919 QSVIVWDKQTTQLLEELKGHDSQVSCVKMLS-GERVLTAAHDGTVKMWDVRTDMCVATVGRCSSAILSLEYDDSTGILAA 997
Cdd:COG2319   184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  998 AGRDTVANIWDIRSGKQMHKLKGHTKWIRSIRMVED--TLITGSDDWTARVWSVSRGSCDAVLACHAGPVQSVEYSPFDK 1075
Cdd:COG2319   264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK 343

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 297339996 1076 GIITGSADGLLRFWENDDGgiKCVKNITLHSSSILSI--NAGENWLGIGAADNS 1127
Cdd:COG2319   344 TLASGSDDGTVRLWDLATG--ELLRTLTGHTGAVTSVafSPDGRTLASGSADGT 395
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 891-1182 6.90e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 187.16  E-value: 6.90e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  891 LRATLKGHTGTVR--AISSDRGKIVSGSDDQSVIVWDKQTTQLLEELKGHDSQVSCVKMLS-GERVLTAAHDGTVKMWDV 967
Cdd:cd00200     1 LRRTLKGHTGGVTcvAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASAdGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  968 RTDMCVATVGRCSSAILSLEYDDSTGILAAAGRDTVANIWDIRSGKQMHKLKGHTKWIRSIRMVEDT--LITGSDDWTAR 1045
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996 1046 VWSVSRGSCDAVLACHAGPVQSVEYSPFDKGIITGSADGLLRFWENDDGgiKCVKNITLHSSSILSI--NAGENWLGIGA 1123
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG--KCLGTLRGHENGVNSVafSPDGYLLASGS 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 297339996 1124 ADNSMSLFhrpssagtKVSGWQLYRVPQRTAAVVRCVASDLERKRICSGGRNGVLRLWD 1182
Cdd:cd00200   239 EDGTIRVW--------DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
820-1184 9.09e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 179.34  E-value: 9.09e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  820 ASSDIAAAAQKKIQTNVRVLKGHGGAVTALHSVTRREVCDLVGDREDAGFFISGSTDCLVKIWDpsLRGSELRATLKGHT 899
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLD--AAAGALLATLLGHT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  900 GTVR--AISSDRGKIVSGSDDQSVIVWDKQTTQLLEELKGHDSQVSCVKmLS--GERVLTAAHDGTVKMWDVRTDMCVAT 975
Cdd:COG2319    79 AAVLsvAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVA-FSpdGKTLASGSADGTVRLWDLATGKLLRT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  976 VGRCSSAILSLEYDDSTGILAAAGRDTVANIWDIRSGKQMHKLKGHTKWIRSIRMVED--TLITGSDDWTARVWSVSRGS 1053
Cdd:COG2319   158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRLWDLATGK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996 1054 CDAVLACHAGPVQSVEYSPFDKGIITGSADGLLRFWENDDGgiKCVKNITLHSSSILSI--NAGENWLGIGAADNSMSLF 1131
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGHSGGVNSVafSPDGKLLASGSDDGTVRLW 315

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 297339996 1132 HrpssagtkVSGWQLYRVPQRTAAVVRCVASDLERKRICSGGRNGVLRLWDAT 1184
Cdd:COG2319   316 D--------LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 122-304 9.11e-47

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 165.82  E-value: 9.11e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996   122 YADKCICLVSHAPNFRVLRNSLEEIFVLCFSSegsckPLWDII-TYMVS---NVPLPTPGKDRVLFAV---ENCLLsveA 194
Cdd:pfam02141    1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTIS-----PLPNPIeRFIANllyEVPFPPPGRTQKLKPLggtEPILL---Q 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996   195 PPEDS-LPQADISLQPLVQCLDVDNLIKLFTSVLVERRILIRSNKYSLLTLVSESICHMIYPFRWQQVYIPLLFFSGVDY 273
Cdd:pfam02141   73 RPEDSeLPLEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDV 152

                          170       180       190
                   ....*....|....*....|....*....|..
gi 297339996   274 IDAPTPYMMGLHSDV-DTSYLAMEGVVVVDLD 304
Cdd:pfam02141  153 LSAPTPFIIGVHSRYfDLLEDPLDDVVLVDLD 184
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 836-1048 2.86e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.42  E-value: 2.86e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  836 VRVLKGHGGAVTAlhsvtrrevCDLVGDREdagFFISGSTDCLVKIWDpsLRGSELRATLKGHTGTVR--AISSDRGKIV 913
Cdd:cd00200    86 VRTLTGHTSYVSS---------VAFSPDGR---ILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWVNsvAFSPDGTFVA 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  914 SGSDDQSVIVWDKQTTQLLEELKGHDSQVSCVKML-SGERVLTAAHDGTVKMWDVRTDMCVATVGRCSSAILSLEYDDST 992
Cdd:cd00200   152 SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 297339996  993 GILAAAGRDTVANIWDIRSGKQMHKLKGHTKWIRSIRMVED--TLITGSDDWTARVWS 1048
Cdd:cd00200   232 YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
836-1011 7.73e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.70  E-value: 7.73e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  836 VRVLKGHGGAVTALhSVTRrevcdlvgdreDAGFFISGSTDCLVKIWDpsLRGSELRATLKGHTGTVR--AISSDRGKIV 913
Cdd:COG2319   239 LRTLTGHSGSVRSV-AFSP-----------DGRLLASGSADGTVRLWD--LATGELLRTLTGHSGGVNsvAFSPDGKLLA 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  914 SGSDDQSVIVWDKQTTQLLEELKGHDSQVSCVKMLS-GERVLTAAHDGTVKMWDVRTDMCVATVGRCSSAILSLEYDDST 992
Cdd:COG2319   305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDG 384

                         170
                  ....*....|....*....
gi 297339996  993 GILAAAGRDTVANIWDIRS 1011
Cdd:COG2319   385 RTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 980-1183 9.53e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 9.53e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  980 SSAILSLEYDDSTGILAAAGRDTVANIWDIRSGKQMHKLKGHTKWIRSIRMVEDT--LITGSDDWTARVWSVSRGSCDAV 1057
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGtyLASGSSDKTIRLWDLETGECVRT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996 1058 LACHAGPVQSVEYSPFDKGIITGSADGLLRFWENDDGgiKCVKNITLHSSSilsinagenwlgigaadnsmslfhrpssa 1137
Cdd:cd00200    89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRGHTDW----------------------------- 137

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 297339996 1138 gtkvsgwqlyrvpqrtaavVRCVASDLERKRICSGGRNGVLRLWDA 1183
Cdd:cd00200   138 -------------------VNSVAFSPDGTFVASSSQDGTIKLWDL 164
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 1-103 4.45e-16

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 74.29  E-value: 4.45e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996      1 MGRIFEYFVVCGLGPEIrtvdgdlgfHGMQTFYLPALLDQFPPTDQSPYPAPPPQLPTCvLPAGVEFhssgfVSSDPASF 80
Cdd:smart00800    1 PSRLFDYFVVVGLDSDT---------GPLGRSYKPEILQRYPEKDFEDFPLPDSIPLFC-FPEGLDF-----VTQTSSKD 65

                            90       100
                    ....*....|....*....|...
gi 297339996     81 PRSYPIVLTEGDGSKIFVSCIAF 103
Cdd:smart00800   66 PQFFSFVLTDIDGSRRYGFCLRF 88
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 366-430 6.00e-12

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 61.92  E-value: 6.00e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 297339996    366 DLQLRVIFLKFFASILGGYRNFIENK--------VFSSDAFLKRRSRTTnqppEPMLVQFLGSFAFLDYLERR 430
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRELrkepgpviTFDKESFLKSRPSSE----RPFLSKFLETQMFSQFIEER 69
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 909-1050 1.59e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.49  E-value: 1.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  909 RGKIVSGSDDQSVIVWDKQTTQLLEELKGHDSQVSCVKMLSGERVLTA--AHDGTVKMWDVRTDMCVATVgRCSSAILSL 986
Cdd:PLN00181  545 KSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAsgSDDGSVKLWSINQGVSIGTI-KTKANICCV 623

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 297339996  987 EYDDSTG-ILAAAGRDTVANIWDIRSGK-QMHKLKGHTKWIRSIRMVE-DTLITGSDDWTARVWSVS 1050
Cdd:PLN00181  624 QFPSESGrSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDsSTLVSSSTDNTLKLWDLS 690
PTZ00421 PTZ00421
coronin; Provisional
 908-1096 3.01e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.51  E-value: 3.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  908 DRGKIVSGSDDQSVIVWD-------KQTTQLLEELKGHDSQVSCVKML-SGERVL-TAAHDGTVKMWDVRTDMCVATVGR 978
Cdd:PTZ00421   87 DPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHpSAMNVLaSAGADMVVNVWDVERGKAVEVIKC 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  979 CSSAILSLEYDDSTGILAAAGRDTVANIWDIRSGKQMHKLKGHTKwIRSIRMV----EDTLIT----GSDDWTARVWSVS 1050
Cdd:PTZ00421  167 HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHAS-AKSQRCLwakrKDLIITlgcsKSQQRQIMLWDTR 245

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 297339996 1051 RgscdavlacHAGPVQSVEYSP--------FDKG----IITGSADGLLRFWENDDGGI 1096
Cdd:PTZ00421  246 K---------MASPYSTVDLDQssalfipfFDEDtnllYIGSKGEGNIRCFELMNERL 294
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 35-101 6.30e-06

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 44.52  E-value: 6.30e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 297339996    35 PALLDQFPPTDQSPYPAPPPQLPTCvLPAGVEFHSSgfvssdpaSFPRSYPIVLTEGDGSKIFVSCI 101
Cdd:pfam03456    1 PEVLDRYPEDDWSDPPLPDGIPMFC-FPEGLETLSS--------REPTFFSFVLTDEDGSRLYGACL 58
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 890-925 2.01e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 2.01e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 297339996    890 ELRATLKGHTGTVRAI--SSDRGKIVSGSDDQSVIVWD 925
Cdd:smart00320    3 ELLKTLKGHTGPVTSVafSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1052-1090 4.50e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 4.50e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 297339996   1052 GSCDAVLACHAGPVQSVEYSPFDKGIITGSADGLLRFWE 1090
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 928-966 6.47e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 6.47e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 297339996    928 TTQLLEELKGHDSQVSCVKML-SGERVLTAAHDGTVKMWD 966
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
889-925 6.96e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 6.96e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 297339996   889 SELRATLKGHTGTVRAI--SSDRGKIVSGSDDQSVIVWD 925
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLafSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1011-1048 9.97e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 9.97e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 297339996   1011 SGKQMHKLKGHTKWIRSIRMVED--TLITGSDDWTARVWS 1048
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDgkYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 872-1022 1.22e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.23  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  872 SGSTDCLVKIWDpsLRGSELRATLKGHTGTVRAI---SSDRGKIVSGSDDQSVIVWDKQTTQLLEELKGhDSQVSCVKML 948
Cdd:PLN00181  550 SSNFEGVVQVWD--VARSQLVTEMKEHEKRVWSIdysSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFP 626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297339996  949 S--GERVLTAAHDGTVKMWDVRT-DMCVATVGRCSSAILSLEYDDSTgILAAAGRDTVANIWDIR---SG---KQMHKLK 1019
Cdd:PLN00181  627 SesGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSS-TLVSSSTDNTLKLWDLSmsiSGineTPLHSFM 705


                  ...
gi 297339996 1020 GHT 1022
Cdd:PLN00181  706 GHT 708
WD40 pfam00400
WD domain, G-beta repeat;
1012-1048 1.53e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.53e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 297339996  1012 GKQMHKLKGHTKWIRSIRMVED--TLITGSDDWTARVWS 1048
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDgkLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
930-966 2.11e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 2.11e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 297339996   930 QLLEELKGHDSQVSCVKML-SGERVLTAAHDGTVKMWD 966
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSpDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
1052-1090 2.86e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.86e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 297339996  1052 GSCDAVLACHAGPVQSVEYSPFDKGIITGSADGLLRFWE 1090
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 836-883 9.69e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 9.69e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 297339996    836 VRVLKGHGGAVTALHSVtrrevcdlvgdrEDAGFFISGSTDCLVKIWD 883
Cdd:smart00320    5 LKTLKGHTGPVTSVAFS------------PDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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