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Conserved domains on  [gi|288869464|gb|EFD01763|]
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phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 [Hungatella hathewayi DSM 13479]

Protein Classification

PTS sugar transporter subunit IIA( domain architecture ID 10004459)

PTS mannose/fructose/sorbose family sugar transporter subunit IIA is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), which catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane

CATH:  3.40.930.10
Gene Ontology:  GO:0009401|GO:0016310|GO:0016301|GO:0008643|GO:1902495
PubMed:  11532441|10393270
SCOP:  4001876

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
 5-154 1.57e-32

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 113.02  E-value: 1.57e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288869464   5 LASMINPELVFTDLPCTDRQTFLQYISRRLEEKDYVKC--SFEGAIIEREKKYPTGLPtvnQHVALPHTDVQHAKNPIIV 82
Cdd:COG1762    3 LSDLLTPELILLDLEASSKEEAIEELAELLAEKGYVLDkeEYLEALLEREELGSTGIG---PGIAIPHARPEGVKKPGIA 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288869464  83 PVKFRTPVVFKEMGNgindIPCSMAFVLVVTE--PEKQIDILQSLINLFIKKDFLEELYKEKTREGFLKRLLDE 154
Cdd:COG1762   80 VARLKEPVDFGAMDG----EPVDLVFLLAAPEddSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILELLKEA 149
 
Name Accession Description Interval E-value
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
 5-154 1.57e-32

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 113.02  E-value: 1.57e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288869464   5 LASMINPELVFTDLPCTDRQTFLQYISRRLEEKDYVKC--SFEGAIIEREKKYPTGLPtvnQHVALPHTDVQHAKNPIIV 82
Cdd:COG1762    3 LSDLLTPELILLDLEASSKEEAIEELAELLAEKGYVLDkeEYLEALLEREELGSTGIG---PGIAIPHARPEGVKKPGIA 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288869464  83 PVKFRTPVVFKEMGNgindIPCSMAFVLVVTE--PEKQIDILQSLINLFIKKDFLEELYKEKTREGFLKRLLDE 154
Cdd:COG1762   80 VARLKEPVDFGAMDG----EPVDLVFLLAAPEddSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILELLKEA 149
PTS_EIIA_2 pfam00359
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
9-151 3.25e-30

Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;


Pssm-ID: 459780 [Multi-domain]  Cd Length: 139  Bit Score: 106.52  E-value: 3.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288869464    9 INPELVFTDLPCTDRQTFLQYISRRLEEKDYVKCSFEGAIIEREKKYPTGLptvNQHVALPHTDVQHAKNPIIVPVKFRT 88
Cdd:pfam00359   2 LDKELIFLNLEAKSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGI---GNGIAIPHARSEAVKKPGIAVLTLKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288869464   89 PVVFKemgnGINDIPCSMAFVLVVTEPEK-QIDILQSLINLFIKKDFLEELYKEKTREGFLKRL 151
Cdd:pfam00359  79 PVDFG----SEDGKPVKLIFLLAAPDNEAsHLKILSQLARLLQDEEFVEKLLKAKDPEEILEIL 138
PTS_IIA_fru cd00211
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 9-151 2.87e-26

PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238129 [Multi-domain]  Cd Length: 136  Bit Score: 96.48  E-value: 2.87e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288869464   9 INPELVFTDLPCTDRQTFLQYISRRLEEKDYVKCSFEGAIIEREKKYPTGLPtvnQHVALPHTDVQHAKNPIIVPVKFRT 88
Cdd:cd00211    1 LTKENIRLNLKAKSKEEAIEELAQLLVAAGYVEEEYIEALLEREKEGSTGIG---NGIAIPHAKSEAVKKPGIAVLRLKE 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 288869464  89 PVVFKEMGNGINDIpcsmAFVLVVTEPEKQIDILQSLINLFIKKDFLEELYKEKTREGFLKRL 151
Cdd:cd00211   78 PVDFGSLDGQPVHL----IFLLAAPDSNEHLKALSQLARLLSDEEFVEQLLNAQSKEEILALL 136
PRK09665 PRK09665
PTS galactitol transporter subunit IIA;
13-138 6.56e-16

PTS galactitol transporter subunit IIA;


Pssm-ID: 182023 [Multi-domain]  Cd Length: 150  Bit Score: 70.22  E-value: 6.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288869464  13 LVFTDLPCTDRQTFLQYISRRLEEKDYVKCSFEGAIIEREKKYPTGLPTVNQHVALPHTDVQHAKNPIIVPVKFRTPVVF 92
Cdd:PRK09665   5 FVRTGISFVDRSEALTHIGNEMLAKGVVHDTYPQALIAREAEFPTGIMLEQHAVAIPHCEAIHAKSPAIYLIRPDKKVHF 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 288869464  93 KEMGNGiNDIPCSMAFVLVVTEPEKQIDILQSLINLFIKKDFLEEL 138
Cdd:PRK09665  85 QQADDD-NDVAVSLVIALIVENPQQQLKLLRCLFGKLQQPDIVETL 129
fruA TIGR00848
PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family ...
 9-138 6.39e-09

PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Fru family is a large and complex family which includes several sequenced fructose and mannitol-specific permeases as well as several putative PTS permeases of unknown specificities. The fructose permeases of this family phosphorylate fructose on the 1-position. Those of family 4.6 phosphorylate fructose on the 6-position. The Fru family PTS systems typically have 3 domains, IIA, IIB and IIC, which may be found as 1 or more proteins. The fructose and mannitol transporters form separate phylogenetic clusters in this family. This model is specific for the IIA domain of the fructose PTS transporters. Also similar to the Enzyme IIA Fru subunits of the PTS, but included in TIGR01419 rather than this model, is enzyme IIA Ntr (nitrogen), also called PtsN, found in E. coli and other organisms, which may play a solely regulatory role. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273298 [Multi-domain]  Cd Length: 129  Bit Score: 51.12  E-value: 6.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288869464    9 INPELVFTDLPCTDRQTFLQYISRRLEEKDYV--KCSFEGAIIEREKKYPTGLPTvnqHVALPHTDVQHAKNPIIVPVKF 86
Cdd:TIGR00848   2 LNKDLIFLDQQFTSKEDVIKFLANKLLENGYIsdTEEFLEDLLKREEEGTTGIGD---GVAIPHAKSAAVKQPFVAIARL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 288869464   87 RTPVVFK-EMGNGINDIpcSMAFVLVVTEPEKQIDILQSLINLFIKKDFLEEL 138
Cdd:TIGR00848  79 VKGVDWQsLDGKPVKLI--FLIAVPKDEAGNTHLKALSQLARLLLNDEFRAKL 129
 
Name Accession Description Interval E-value
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
 5-154 1.57e-32

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 113.02  E-value: 1.57e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288869464   5 LASMINPELVFTDLPCTDRQTFLQYISRRLEEKDYVKC--SFEGAIIEREKKYPTGLPtvnQHVALPHTDVQHAKNPIIV 82
Cdd:COG1762    3 LSDLLTPELILLDLEASSKEEAIEELAELLAEKGYVLDkeEYLEALLEREELGSTGIG---PGIAIPHARPEGVKKPGIA 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288869464  83 PVKFRTPVVFKEMGNgindIPCSMAFVLVVTE--PEKQIDILQSLINLFIKKDFLEELYKEKTREGFLKRLLDE 154
Cdd:COG1762   80 VARLKEPVDFGAMDG----EPVDLVFLLAAPEddSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILELLKEA 149
PTS_EIIA_2 pfam00359
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
9-151 3.25e-30

Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;


Pssm-ID: 459780 [Multi-domain]  Cd Length: 139  Bit Score: 106.52  E-value: 3.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288869464    9 INPELVFTDLPCTDRQTFLQYISRRLEEKDYVKCSFEGAIIEREKKYPTGLptvNQHVALPHTDVQHAKNPIIVPVKFRT 88
Cdd:pfam00359   2 LDKELIFLNLEAKSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGI---GNGIAIPHARSEAVKKPGIAVLTLKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288869464   89 PVVFKemgnGINDIPCSMAFVLVVTEPEK-QIDILQSLINLFIKKDFLEELYKEKTREGFLKRL 151
Cdd:pfam00359  79 PVDFG----SEDGKPVKLIFLLAAPDNEAsHLKILSQLARLLQDEEFVEKLLKAKDPEEILEIL 138
PTS_IIA_fru cd00211
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 9-151 2.87e-26

PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238129 [Multi-domain]  Cd Length: 136  Bit Score: 96.48  E-value: 2.87e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288869464   9 INPELVFTDLPCTDRQTFLQYISRRLEEKDYVKCSFEGAIIEREKKYPTGLPtvnQHVALPHTDVQHAKNPIIVPVKFRT 88
Cdd:cd00211    1 LTKENIRLNLKAKSKEEAIEELAQLLVAAGYVEEEYIEALLEREKEGSTGIG---NGIAIPHAKSEAVKKPGIAVLRLKE 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 288869464  89 PVVFKEMGNGINDIpcsmAFVLVVTEPEKQIDILQSLINLFIKKDFLEELYKEKTREGFLKRL 151
Cdd:cd00211   78 PVDFGSLDGQPVHL----IFLLAAPDSNEHLKALSQLARLLSDEEFVEQLLNAQSKEEILALL 136
PRK09665 PRK09665
PTS galactitol transporter subunit IIA;
13-138 6.56e-16

PTS galactitol transporter subunit IIA;


Pssm-ID: 182023 [Multi-domain]  Cd Length: 150  Bit Score: 70.22  E-value: 6.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288869464  13 LVFTDLPCTDRQTFLQYISRRLEEKDYVKCSFEGAIIEREKKYPTGLPTVNQHVALPHTDVQHAKNPIIVPVKFRTPVVF 92
Cdd:PRK09665   5 FVRTGISFVDRSEALTHIGNEMLAKGVVHDTYPQALIAREAEFPTGIMLEQHAVAIPHCEAIHAKSPAIYLIRPDKKVHF 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 288869464  93 KEMGNGiNDIPCSMAFVLVVTEPEKQIDILQSLINLFIKKDFLEEL 138
Cdd:PRK09665  85 QQADDD-NDVAVSLVIALIVENPQQQLKLLRCLFGKLQQPDIVETL 129
PRK09765 PRK09765
PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional
 5-159 1.20e-09

PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional


Pssm-ID: 182066 [Multi-domain]  Cd Length: 631  Bit Score: 55.90  E-value: 1.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288869464   5 LASMINPELVFTDLPCTDRQTFLQYISRRLEE--KDYVKCSFEGAIIEREKKYPTGLptvNQHVALPHTDVQHAKNPIIV 82
Cdd:PRK09765   3 LTTLTHRDLLCLNARFTSREEAIHALAQRLAAlgKISSTEQFLEEVYRRESLGPTAL---GEGLAVPHGKTAAVKEAAFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288869464  83 PVKFRTPVVFKemgnGIN-DIPCSMAFVLVVTEPE---KQIDILQSLINLFIKKDFLEELYKEKTREGFLkRLLDEAEKD 158
Cdd:PRK09765  80 VATLSEPLQWE----GVDgPEAVDLIFLLAIPPNEagtTHMQLLTALTTRLADDEIRARIQSATTPDELL-SALDDKGGT 154


                 .
gi 288869464 159 E 159
Cdd:PRK09765 155 Q 155
fruA TIGR00848
PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family ...
 9-138 6.39e-09

PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Fru family is a large and complex family which includes several sequenced fructose and mannitol-specific permeases as well as several putative PTS permeases of unknown specificities. The fructose permeases of this family phosphorylate fructose on the 1-position. Those of family 4.6 phosphorylate fructose on the 6-position. The Fru family PTS systems typically have 3 domains, IIA, IIB and IIC, which may be found as 1 or more proteins. The fructose and mannitol transporters form separate phylogenetic clusters in this family. This model is specific for the IIA domain of the fructose PTS transporters. Also similar to the Enzyme IIA Fru subunits of the PTS, but included in TIGR01419 rather than this model, is enzyme IIA Ntr (nitrogen), also called PtsN, found in E. coli and other organisms, which may play a solely regulatory role. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273298 [Multi-domain]  Cd Length: 129  Bit Score: 51.12  E-value: 6.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288869464    9 INPELVFTDLPCTDRQTFLQYISRRLEEKDYV--KCSFEGAIIEREKKYPTGLPTvnqHVALPHTDVQHAKNPIIVPVKF 86
Cdd:TIGR00848   2 LNKDLIFLDQQFTSKEDVIKFLANKLLENGYIsdTEEFLEDLLKREEEGTTGIGD---GVAIPHAKSAAVKQPFVAIARL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 288869464   87 RTPVVFK-EMGNGINDIpcSMAFVLVVTEPEKQIDILQSLINLFIKKDFLEEL 138
Cdd:TIGR00848  79 VKGVDWQsLDGKPVKLI--FLIAVPKDEAGNTHLKALSQLARLLLNDEFRAKL 129
MtlA2 COG4668
Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and ...
 9-151 2.15e-05

Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism];


Pssm-ID: 443705 [Multi-domain]  Cd Length: 143  Bit Score: 42.07  E-value: 2.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288869464   9 INPELVFTDLPCTDRQTFLQYISRRLEEKDYVKCSFEGAIIEREKKYPTGLptvNQHVALPH---TDVQHAKNPIIVPVK 85
Cdd:COG4668    4 LTKENIRLNASAANKEEAIRLAGQLLVEAGYVEPEYIDAMLEREAQVSTYL---GNGIAIPHgtnEAKDLVLKTGISVLQ 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 288869464  86 FRTPVVFKEmGNgindipcsMAFVLVV--TEPEKQIDILQSLINLFIKKDFLEELYKEKTREGFLKRL 151
Cdd:COG4668   81 FPDGVDWGD-GN--------TVYLVIGiaAKSDEHLEILRQLARVLSDEENVEKLAKATDAEEILALL 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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