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Conserved domains on  [gi|258583967|gb|EEW08757|]
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polar amino acid ABC transporter, permease protein [Vibrio mimicus VM603]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 36-260 8.75e-65

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 201.46  E-value: 8.75e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  36 YQWQWHRVPEYVlifedgewwaGDLMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQ 115
Cdd:COG0765    1 MFFDFSVLLDYL----------PLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQ 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967 116 IYLLYFVFGPV-IGLDRFATAVLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLT 194
Cdd:COG0765   71 LFFIYFGLPLLgIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLG 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 258583967 195 NEMVSLIKNSSIVSVMAIFDLTTQGRNIVSETAMPFEIWFSVAAIYLLLTLTLSALSAWLEHKLGA 260
Cdd:COG0765  151 NEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLAR 216
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 36-260 8.75e-65

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 201.46  E-value: 8.75e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  36 YQWQWHRVPEYVlifedgewwaGDLMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQ 115
Cdd:COG0765    1 MFFDFSVLLDYL----------PLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQ 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967 116 IYLLYFVFGPV-IGLDRFATAVLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLT 194
Cdd:COG0765   71 LFFIYFGLPLLgIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLG 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 258583967 195 NEMVSLIKNSSIVSVMAIFDLTTQGRNIVSETAMPFEIWFSVAAIYLLLTLTLSALSAWLEHKLGA 260
Cdd:COG0765  151 NEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLAR 216
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 60-258 3.80e-31

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 114.95  E-value: 3.80e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967   60 LMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQIYLLYFVFgPVIGL--DRFATAVL 137
Cdd:TIGR03004   7 LLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVL-PLIGLslDPVTTGVM 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  138 ALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLTNEMVSLIKNSSIVSVMAIFDLTT 217
Cdd:TIGR03004  86 VLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADLTF 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 258583967  218 QGRNIVSETAMPFEIWFSVAAIYLLLTLTLSALSAWLEHKL 258
Cdd:TIGR03004 166 AAQSIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLERVV 206
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 59-258 3.66e-28

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 107.06  E-value: 3.66e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  59 DLMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQIYLLYF---VFGPVIGLDRFATA 135
Cdd:PRK09494  14 LLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFalpMAFNDLRIDPFTAA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967 136 VLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLTNEMVSLIKNSSIVSVMAIFDL 215
Cdd:PRK09494  94 VVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVAEL 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 258583967 216 TTQGRNIVSETAMPFEIWFSVAAIYLLLTLTLSALSAWLEHKL 258
Cdd:PRK09494 174 TRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERRM 216
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 64-240 5.99e-16

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 73.85  E-value: 5.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  64 LLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQIYLLYFVFGPVIGLDRFA----TAVLAL 139
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPglglPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967 140 ALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLTNEMVSLIKNSSIVSVMAIFDLTTQG 219
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180
                 ....*....|....*....|.
gi 258583967 220 RNIVSETAMPFEIWFSVAAIY 240
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAV 181
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 91-239 3.28e-11

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 60.78  E-value: 3.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967   91 SRSLVGRALGTGYIAVVRNTPLLVQIYLLYFVFGPVIGLDRFATAVLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLG 170
Cdd:pfam00528  11 RRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALG 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  171 LSRFFTFYDVILPQLLQRTLPPLTNEMVSLIKNSSIVS-VMAIFDLTTQGRNIVSETAMPFEIWFSVAAI 239
Cdd:pfam00528  91 ASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEfLGSWPGLGLLLIEAILGYDYPEIQGPVLAAA 160
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 36-260 8.75e-65

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 201.46  E-value: 8.75e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  36 YQWQWHRVPEYVlifedgewwaGDLMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQ 115
Cdd:COG0765    1 MFFDFSVLLDYL----------PLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQ 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967 116 IYLLYFVFGPV-IGLDRFATAVLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLT 194
Cdd:COG0765   71 LFFIYFGLPLLgIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLG 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 258583967 195 NEMVSLIKNSSIVSVMAIFDLTTQGRNIVSETAMPFEIWFSVAAIYLLLTLTLSALSAWLEHKLGA 260
Cdd:COG0765  151 NEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLAR 216
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 60-260 1.69e-48

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 160.26  E-value: 1.69e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  60 LMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQIYLLYFVFGPVIGL---------- 129
Cdd:COG4160   13 LLSGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLGQFEWVreswlwpllr 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967 130 DRFATAVLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLTNEMVSLIKNSSIVSV 209
Cdd:COG4160   93 DPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEVILMLKATALAST 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258583967 210 MAIFDLTTQGRNIVSETAMPFEIWFSVAAIYLLLTLTLSALSAWLEHKLGA 260
Cdd:COG4160  173 ITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRLLR 223
ArtQ COG4215
ABC-type arginine transport system, permease component [Amino acid transport and metabolism];
56-265 1.48e-40

ABC-type arginine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443361 [Multi-domain]  Cd Length: 238  Bit Score: 139.87  E-value: 1.48e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  56 WAGDLMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQIYLLYF-----------VFG 124
Cdd:COG4215   14 WGPALLAGALVTLELALLSLLLGLVLGLLGALAKLSGNRPLRWLATGYTTVVRGVPDLLLILLLYFggqillnaladLFG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967 125 P--VIGLDRFATAVLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLTNEMVSLIK 202
Cdd:COG4215   94 YdgFIEINPFVAGVLALGFVFGAYATEVFRGAFLAVPKGQIEAARAYGMSRWQVFRRILLPQMWRYALPGLGNNWLVLLK 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 258583967 203 NSSIVSVMAIFDLTTQGRNIVSETAMPFEIWFSVAAIYLLLTLTLSALSAWLEHKLGAQWRSQ 265
Cdd:COG4215  174 DTALVSVIGLVDLVRQAQEAAGSTREPFTFYLAAALIYLALTTVSELVLARLERRASRGVRRA 236
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 60-258 3.80e-31

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 114.95  E-value: 3.80e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967   60 LMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQIYLLYFVFgPVIGL--DRFATAVL 137
Cdd:TIGR03004   7 LLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVL-PLIGLslDPVTTGVM 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  138 ALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLTNEMVSLIKNSSIVSVMAIFDLTT 217
Cdd:TIGR03004  86 VLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADLTF 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 258583967  218 QGRNIVSETAMPFEIWFSVAAIYLLLTLTLSALSAWLEHKL 258
Cdd:TIGR03004 166 AAQSIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLERVV 206
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 60-258 2.04e-29

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 110.33  E-value: 2.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967   60 LMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQIYLLYFVFgPVIG--LDRFATAVL 137
Cdd:TIGR03003  13 LIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVL-PDIGirLPALVAGVL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  138 ALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLTNEMVSLIKNSSIVSVMAIFDLTT 217
Cdd:TIGR03003  92 GLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLELMN 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 258583967  218 QGRNIVSETAMPFEIWFSVAAIYLLLTLTLSALSAWLEHKL 258
Cdd:TIGR03003 172 QAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 59-258 3.66e-28

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 107.06  E-value: 3.66e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  59 DLMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQIYLLYF---VFGPVIGLDRFATA 135
Cdd:PRK09494  14 LLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFalpMAFNDLRIDPFTAA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967 136 VLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLTNEMVSLIKNSSIVSVMAIFDL 215
Cdd:PRK09494  94 VVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVAEL 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 258583967 216 TTQGRNIVSETAMPFEIWFSVAAIYLLLTLTLSALSAWLEHKL 258
Cdd:PRK09494 174 TRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERRM 216
PRK15100 PRK15100
cystine ABC transporter permease;
60-263 5.89e-28

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 106.76  E-value: 5.89e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  60 LMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQIYLLYF---VFGpvIGLDRFATAV 136
Cdd:PRK15100  15 LLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYglpQFG--IELDPIPAAM 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967 137 LALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLTNEMVSLIKNSSIVSVMAIFDLT 216
Cdd:PRK15100  93 IGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELF 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 258583967 217 TQGRNIVSETAMPFEIWFSVAAIYLLLTLTLSALSAWLEHKLGAQWR 263
Cdd:PRK15100 173 RQAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQLNRQER 219
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
60-240 7.38e-24

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 96.28  E-value: 7.38e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  60 LMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQIYLLYF------------------ 121
Cdd:PRK11123   7 LASAAGMTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPEILVVLFIYFgssqllltlsdgftlnlg 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967 122 VFGPVIGLDR-------FATAVLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLT 194
Cdd:PRK11123  87 FVQIPVQMDIenfevspFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLG 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 258583967 195 NEMVSLIKNSSIVSVMAIFDLTTQGRNIVSETAMPFEIWFSVAAIY 240
Cdd:PRK11123 167 NQWLVLLKDTALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIY 212
PRK15069 PRK15069
histidine ABC transporter permease HisM;
55-239 1.35e-20

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 87.41  E-value: 1.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  55 WWAGDLMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQ-------IYLLYFVFGPVI 127
Cdd:PRK15069  14 WTDGYRFTGLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQllvfytgMYSLEIVRGTDL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967 128 gLDRF-----ATAVLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLTNEMVSLIK 202
Cdd:PRK15069  94 -LDAFfrsglNCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLH 172

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 258583967 203 NSSIVSVMAIFDLTTQGRNIVSETAMPFEIwFSVAAI 239
Cdd:PRK15069 173 ATTLAFTATVPDILKIARDINSATYQPFQA-FGIAAV 208
artM PRK11122
arginine ABC transporter permease ArtM;
59-226 6.78e-20

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 85.40  E-value: 6.78e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  59 DLMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQIYLLYFVFGPVIGLDRFAT---- 134
Cdd:PRK11122   7 ELLKGLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGPGQFPWLQEYPWlwhl 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967 135 -------AVLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYdVILPQLLQRTLPPLTNEMVSLIKNSSIV 207
Cdd:PRK11122  87 lsqpwlcAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTLR-ILLPYAFKRALSSYSNEVVLVFKSTSLA 165

                        170
                 ....*....|....*....
gi 258583967 208 SVMAIFDLTTQGRNIVSET 226
Cdd:PRK11122 166 YTITLMDVMGYSQLLYGRT 184
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 118-211 1.65e-18

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 84.04  E-value: 1.65e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967 118 LLYFVFGPVIGLDR-----------------FATAVLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDV 180
Cdd:COG4597  234 LAFLLLGAPLSLDYpelkgfnfrggltlspeFVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLV 313

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 258583967 181 ILPQLLQRTLPPLTNEMVSLIKNSS---------IVSVMA 211
Cdd:COG4597  314 VLPQALRVIIPPLTSQYLNLTKNSSlavaigypdLVSVFA 353
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 58-153 5.39e-16

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 71.41  E-value: 5.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967   58 GDLMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQIYLLYFVFgPVIG--LDRFATA 135
Cdd:TIGR01726   3 PFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGL-PLIGirLSPLTAA 81

                          90
                  ....*....|....*...
gi 258583967  136 VLALALFQGAYTAEVFRG 153
Cdd:TIGR01726  82 VIALTLFYGAYLAEIFRG 99
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 64-240 5.99e-16

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 73.85  E-value: 5.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  64 LLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQIYLLYFVFGPVIGLDRFA----TAVLAL 139
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPglglPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967 140 ALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLTNEMVSLIKNSSIVSVMAIFDLTTQG 219
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180
                 ....*....|....*....|.
gi 258583967 220 RNIVSETAMPFEIWFSVAAIY 240
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAV 181
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
60-257 4.95e-15

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 72.17  E-value: 4.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  60 LMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQIYLLYFV----FGPVIGLD----- 130
Cdd:PRK15107  16 LLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIvpgfLQNVLGLSpktdi 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967 131 RFATAVLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLTNEMVSLIKNSSIVSVM 210
Cdd:PRK15107  96 RLISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVL 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 258583967 211 AIFDLTTQGRNIVSETAMPFEIWFSVAAIYLLLTLTLSALSAWLEHK 257
Cdd:PRK15107 176 SLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKR 222
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
56-257 1.17e-12

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 65.58  E-value: 1.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  56 WAGDLMHGLLVTLQLTGISLIFTLALGLTTALLRQSRSLVGRALGTGYIAVVRNTPLLVQIYLLYFVFGPV--------- 126
Cdd:PRK15135   5 FSGVILQGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQIAlnsvtealg 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967 127 ---IGLDRFATAVLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLLQRTLPPLTNEMVSLIKN 203
Cdd:PRK15135  85 vgqIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKA 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 258583967 204 SSIVSVMAIFDLTTQGRNIVSETAMPFEIWFSVAAIYLLLTLTLSALSAWLEHK 257
Cdd:PRK15135 165 TALVSLLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLWLERR 218
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 91-239 3.28e-11

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 60.78  E-value: 3.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967   91 SRSLVGRALGTGYIAVVRNTPLLVQIYLLYFVFGPVIGLDRFATAVLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLG 170
Cdd:pfam00528  11 RRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALG 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  171 LSRFFTFYDVILPQLLQRTLPPLTNEMVSLIKNSSIVS-VMAIFDLTTQGRNIVSETAMPFEIWFSVAAI 239
Cdd:pfam00528  91 ASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEfLGSWPGLGLLLIEAILGYDYPEIQGPVLAAA 160
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
99-186 1.20e-04

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 42.84  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  99 LGTGYIAVVRNTPLLVQiyLLYFVFG-PVIGLDRFATAVLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTF 177
Cdd:COG1178  107 VALAWIALFGPNGLLNT--LLRALFGlEPPDIYGLGGIILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAF 184


                 ....*....
gi 258583967 178 YDVILPQLL 186
Cdd:COG1178  185 RRVTLPLLR 193
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 119-186 2.33e-04

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 41.64  E-value: 2.33e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 258583967 119 LYFVFGPVIGLDRFATAVLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLL 186
Cdd:COG1177  118 LLLLFSALGLSGGLWGLILAHVVFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIA 185
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 92-186 4.40e-04

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 40.52  E-value: 4.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 258583967  92 RSLVGRALGTGYIAVVRNTPLLVQIYLLYFVFGpvIGldrFATAVLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGL 171
Cdd:COG0600   90 LSRLLRRLLDPLLVFLRPIPPLALAPLLILWFG--IG---EASKIFVIFLGAFFPILLNTAAGVRSVDPELLELARSLGA 164

                         90
                 ....*....|....*
gi 258583967 172 SRFFTFYDVILPQLL 186
Cdd:COG0600  165 SRWQILRKVVLPAAL 179
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 136-186 7.56e-03

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 37.04  E-value: 7.56e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 258583967 136 VLALALFQGAYTAEVFRGGLNSIPQGQYEAARSLGLSRFFTFYDVILPQLL 186
Cdd:COG0555  140 VLAQTFVSLPFVVRTVQPVLEELDPELEEAAATLGASRWQTFRRVILPLLL 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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