|
Name |
Accession |
Description |
Interval |
E-value |
| Peptidase_C19 |
cd02257 |
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ... |
252-520 |
5.82e-49 |
|
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239072 [Multi-domain] Cd Length: 255 Bit Score: 169.59 E-value: 5.82e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 252 EQEDAEEFLNLFLDEMHEEFVRTGNLEKASSPNadavdkdkedkeeegwlevgkkqkpvitrsatvsHSPITEIFGGQLR 331
Cdd:cd02257 21 EQQDAHEFLLFLLDKLHEELKKSSKRTSDSSSL----------------------------------KSLIHDLFGGKLE 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 332 SVLK---VPNARDSVLLEPYQPLPLDIQPDHIHSVLDAMDHLTTPETLKG---WRSPKGHTVTATKQVFIEKLPAVLILH 405
Cdd:cd02257 67 STIVcleCGHESVSTEPELFLSLPLPVKGLPQVSLEDCLEKFFKEEILEGdncYKCEKKKKQEATKRLKIKKLPPVLIIH 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 406 LKRFLYDDQaGGTLKNTKLISYPLRLEIP---TRVISPGKRPLGPARYQLTAVVYHHGLSAQGGHYTVDVHQHDGSSWIR 482
Cdd:cd02257 147 LKRFSFNED-GTKEKLNTKVSFPLELDLSpylSEGEKDSDSDNGSYKYELVAVVVHSGTSADSGHYVAYVKDPSDGKWYK 225
|
250 260 270
....*....|....*....|....*....|....*...
gi 212001672 483 IDDTTIRTISESDVEvteneatvnSSASSDRCAYLLFY 520
Cdd:cd02257 226 FNDDKVTEVSEEEVL---------EFGSLSSSAYILFY 254
|
|
| UCH |
pfam00443 |
Ubiquitin carboxyl-terminal hydrolase; |
160-520 |
1.30e-48 |
|
Ubiquitin carboxyl-terminal hydrolase;
Pssm-ID: 425685 [Multi-domain] Cd Length: 310 Bit Score: 170.32 E-value: 1.30e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 160 RGFVNTSNMCFMNSIFQALLYCVPFyvlmRNLGKKLPRLFRDKGSLLGSVIT--LTQEFRENWQPGEEEgdAYIPEVVYR 237
Cdd:pfam00443 1 TGLVNLGNTCYMNSVLQSLFSIPPF----RDYLLRISPLSEDSRYNKDINLLcaLRDLFKALQKNSKSS--SVSPKMFKK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 238 VM-KNNPRFdlvQTGEQEDAEEFLNLFLDEMHEEFVRTGNLEKASspnadavdkdkedkeeegwlevgkkqkpvitrsat 316
Cdd:pfam00443 75 SLgKLNPDF---SGYKQQDAQEFLLFLLDGLHEDLNGNHSTENES----------------------------------- 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 317 vshsPITEIFGGQLRSVLKVPN-ARDSVLLEPYQPLPLDIQPD----HIHSVLDAMDHLTTPETLKG---WRSPKGH-TV 387
Cdd:pfam00443 117 ----LITDLFRGQLKSRLKCLScGEVSETFEPFSDLSLPIPGDsaelKTASLQICFLQFSKLEELDDeekYYCDKCGcKQ 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 388 TATKQVFIEKLPAVLILHLKRFLYDdqAGGTLKNTKLISYPLRLEIpTRVISPGKRPLGPAR--YQLTAVVYHHGlSAQG 465
Cdd:pfam00443 193 DAIKQLKISRLPPVLIIHLKRFSYN--RSTWEKLNTEVEFPLELDL-SRYLAEELKPKTNNLqdYRLVAVVVHSG-SLSS 268
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 212001672 466 GHYTVDVHQHDGSSWIRIDDTTIRTISESDVEVTENeatvnssassdrcAYLLFY 520
Cdd:pfam00443 269 GHYIAYIKAYENNRWYKFDDEKVTEVDEETAVLSSS-------------AYILFY 310
|
|
| Peptidase_C19E |
cd02661 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
159-520 |
4.91e-38 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239126 [Multi-domain] Cd Length: 304 Bit Score: 141.64 E-value: 4.91e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 159 PRGFVNTSNMCFMNSIFQALLYCVPF--YVLMRNLGKKLPRlfrDKGSLLGSVITLTQEFRENwqpgeeEGDAYIPEVVY 236
Cdd:cd02661 1 GAGLQNLGNTCFLNSVLQCLTHTPPLanYLLSREHSKDCCN---EGFCMMCALEAHVERALAS------SGPGSAPRIFS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 237 RVMKN-NPRFdlvQTGEQEDAEEFLNLFLDEMHeefvrtgnleKASSPNadavdkdkedkeeegwlevGKKQKPVITRSA 315
Cdd:cd02661 72 SNLKQiSKHF---RIGRQEDAHEFLRYLLDAMQ----------KACLDR-------------------FKKLKAVDPSSQ 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 316 TVShsPITEIFGGQLRSVLKVPNAR-DSVLLEPYQPLPLDIQPDHihSVLDAMDHLTTPETLKG---WRSPK-GHTVTAT 390
Cdd:cd02661 120 ETT--LVQQIFGGYLRSQVKCLNCKhVSNTYDPFLDLSLDIKGAD--SLEDALEQFTKPEQLDGenkYKCERcKKKVKAS 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 391 KQVFIEKLPAVLILHLKRFlyddQAGGTLKNTKLISYPLRLEIPTRVISPGKrplGPARYQLTAVVYHHGLSAQGGHYTV 470
Cdd:cd02661 196 KQLTIHRAPNVLTIHLKRF----SNFRGGKINKQISFPETLDLSPYMSQPND---GPLKYKLYAVLVHSGFSPHSGHYYC 268
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 212001672 471 DVHQHDGsSWIRIDDTTIRTISESDVevteneatvnssaSSDRcAYLLFY 520
Cdd:cd02661 269 YVKSSNG-KWYNMDDSKVSPVSIETV-------------LSQK-AYILFY 303
|
|
| Peptidase_C19R |
cd02674 |
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
252-521 |
5.44e-33 |
|
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239139 [Multi-domain] Cd Length: 230 Bit Score: 125.48 E-value: 5.44e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 252 EQEDAEEFLNLFLDEMHeefvrtgnlekasspnadavdkdkedkeeegwlevgkkqkpvitrsatvshSPITEIFGGQLR 331
Cdd:cd02674 21 DQQDAQEFLLFLLDGLH---------------------------------------------------SIIVDLFQGQLK 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 332 SVLKVPNA-RDSVLLEPYQPLPLDI-----QPDHIhSVLDAMDHLTTPETLKG---WRSPKGHTVT-ATKQVFIEKLPAV 401
Cdd:cd02674 50 SRLTCLTCgKTSTTFEPFTYLSLPIpsgsgDAPKV-TLEDCLRLFTKEETLDGdnaWKCPKCKKKRkATKKLTISRLPKV 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 402 LILHLKRFLYDDqaGGTLKNTKLISYPLRLEIPTRVISPGkRPLGPARYQLTAVVYHHGlSAQGGHYTVDVHQHDGSSWI 481
Cdd:cd02674 129 LIIHLKRFSFSR--GSTRKLTTPVTFPLNDLDLTPYVDTR-SFTGPFKYDLYAVVNHYG-SLNGGHYTAYCKNNETNDWY 204
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 212001672 482 RIDDTTIRTISESDVevteneatVNSSassdrcAYLLFYT 521
Cdd:cd02674 205 KFDDSRVTKVSESSV--------VSSS------AYILFYE 230
|
|
| Peptidase_C19D |
cd02660 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
160-521 |
6.11e-31 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239125 [Multi-domain] Cd Length: 328 Bit Score: 122.48 E-value: 6.11e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 160 RGFVNTSNMCFMNSIFQALLYcVPfyvLMRN--LGKKLPRLFRDKGSLLGSVITLTQEFRENWQPGEEEGdaYIP-EVVY 236
Cdd:cd02660 1 RGLINLGATCFMNVILQALLH-NP---LLRNyfLSDRHSCTCLSCSPNSCLSCAMDEIFQEFYYSGDRSP--YGPiNLLY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 237 RVMKNNPrfDLVQTGEQeDAEEFLNLFLDEMHEEFVrtGNLEKASSPNAdavdkdkedkeeegwlevgkkqkpvitrsat 316
Cdd:cd02660 75 LSWKHSR--NLAGYSQQ-DAHEFFQFLLDQLHTHYG--GDKNEANDESH------------------------------- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 317 vSHSPITEIFGGQLRSVL------KVPNARDsvllePYQPLPLDIQPDHIHSVLDAMDHLTTPETLKG-----WRSPK-- 383
Cdd:cd02660 119 -CNCIIHQTFSGSLQSSVtcqrcgGVSTTVD-----PFLDLSLDIPNKSTPSWALGESGVSGTPTLSDcldrfTRPEKlg 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 384 ---------GHTVTATKQVFIEKLPAVLILHLKRFLYdDQAGGTLKNTKLISYPLRL--------EIPTRVISPGKRPLg 446
Cdd:cd02660 193 dfaykcsgcGSTQEATKQLSIKKLPPVLCFQLKRFEH-SLNKTSRKIDTYVQFPLELnmtpytssSIGDTQDSNSLDPD- 270
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212001672 447 pARYQLTAVVYHHGlSAQGGHYTVDVHQHDGsSWIRIDDTTIRTISESDVEVTEneatvnssassdrcAYLLFYT 521
Cdd:cd02660 271 -YTYDLFAVVVHKG-TLDTGHYTAYCRQGDG-QWFKFDDAMITRVSEEEVLKSQ--------------AYLLFYH 328
|
|
| Peptidase_C19G |
cd02663 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
161-521 |
3.94e-26 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239128 [Multi-domain] Cd Length: 300 Bit Score: 108.17 E-value: 3.94e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 161 GFVNTSNMCFMNSIFQALLYCVPFYVLmrnlgKKLPRLFRDKGSLLGSVITltQEFrenwqpgeeegdayipevVYRVMK 240
Cdd:cd02663 1 GLENFGNTCYCNSVLQALYFENLLTCL-----KDLFESISEQKKRTGVISP--KKF------------------ITRLKR 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 241 NNPRFDlvqTGEQEDAEEFLNLFLDEMHEefvrtgNLEKASSPNAdavdkdkedkeeegwlevgKKQKPVITRSATVSHS 320
Cdd:cd02663 56 ENELFD---NYMHQDAHEFLNFLLNEIAE------ILDAERKAEK-------------------ANRKLNNNNNAEPQPT 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 321 PITEIFGGQLRSVLKVPN-----ARDsvllEPYQPLPLDIQPDHihSVLDAMDHLTTPETLKGwrSPKGHTVT------A 389
Cdd:cd02663 108 WVHEIFQGILTNETRCLTcetvsSRD----ETFLDLSIDVEQNT--SITSCLRQFSATETLCG--RNKFYCDEccslqeA 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 390 TKQVFIEKLPAVLILHLKRFLYDDQAGgtlKNTKL---ISYPLRLeiptRVISPGKRPLGPAR-YQLTAVVYHHGLSAQG 465
Cdd:cd02663 180 EKRMKIKKLPKILALHLKRFKYDEQLN---RYIKLfyrVVFPLEL----RLFNTTDDAENPDRlYELVAVVVHIGGGPNH 252
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 212001672 466 GHYTVDVHQHDGssWIRIDDTTIRTISESDVEvtenEATVNSSASSdrCAYLLFYT 521
Cdd:cd02663 253 GHYVSIVKSHGG--WLLFDDETVEKIDENAVE----EFFGDSPNQA--TAYVLFYQ 300
|
|
| peptidase_C19C |
cd02659 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
161-524 |
1.23e-24 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239124 [Multi-domain] Cd Length: 334 Bit Score: 104.65 E-value: 1.23e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 161 GFVNTSNMCFMNSIFQALlYCVPFYvlmRNLGKKLPRLFRDKGSllGSVITLTQEFRENWQPGEEEGDAYIPEVVYRVMK 240
Cdd:cd02659 4 GLKNQGATCYMNSLLQQL-YMTPEF---RNAVYSIPPTEDDDDN--KSVPLALQRLFLFLQLSESPVKTTELTDKTRSFG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 241 NNPrfdlVQTGEQEDAEEFLNLFLDEMHEEFVRTGnlekasspnadavdkdkedkeeegwlevgkkQKPVITRsatvshs 320
Cdd:cd02659 78 WDS----LNTFEQHDVQEFFRVLFDKLEEKLKGTG-------------------------------QEGLIKN------- 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 321 piteIFGGQLRS---VLKVPN--ARDsvllEPYQPLPLDIQPdhIHSVLDAMDHLTTPETLKG----WRSPKGHTVTATK 391
Cdd:cd02659 116 ----LFGGKLVNyiiCKECPHesERE----EYFLDLQVAVKG--KKNLEESLDAYVQGETLEGdnkyFCEKCGKKVDAEK 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 392 QVFIEKLPAVLILHLKRFLYDDQaggTLKNTKL---ISYPLRL--------EIPTRVISPGKRPLGPARYQLTAVVYHHG 460
Cdd:cd02659 186 GVCFKKLPPVLTLQLKRFEFDFE---TMMRIKIndrFEFPLELdmepytekGLAKKEGDSEKKDSESYIYELHGVLVHSG 262
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 212001672 461 lSAQGGHYTVDVHQHDGSSWIRIDDTTIRTISESDVEVT--------ENEATVNSSASSDRCAYLLFYTRCE 524
Cdd:cd02659 263 -DAHGGHYYSYIKDRDDGKWYKFNDDVVTPFDPNDAEEEcfggeetqKTYDSGPRAFKRTTNAYMLFYERKS 333
|
|
| Peptidase_C19K |
cd02667 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
161-520 |
3.50e-23 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239132 [Multi-domain] Cd Length: 279 Bit Score: 99.38 E-value: 3.50e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 161 GFVNTSNMCFMNSIFQALLYCVpfyvLMRNLGKKLPRLFrdkgsllgsvitltqeFREnwqpgeeegdayipevvyrVMK 240
Cdd:cd02667 1 GLSNLGNTCFFNAVMQNLSQTP----ALRELLSETPKEL----------------FSQ-------------------VCR 41
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 241 NNPRFdlvQTGEQEDAEEFLNLFLDEMheefvrtgnlekasspnadavdkdkedkeeegwlevgkkqKPVITRsatvshs 320
Cdd:cd02667 42 KAPQF---KGYQQQDSHELLRYLLDGL----------------------------------------RTFIDS------- 71
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 321 piteIFGGQLRSVLKVPNARD-SVLLEPYQ--PLPLDIQPDHIHSVLDAMDHLTTPETLKGWRSPKGHTVT-ATKQVFIE 396
Cdd:cd02667 72 ----IFGGELTSTIMCESCGTvSLVYEPFLdlSLPRSDEIKSECSIESCLKQFTEVEILEGNNKFACENCTkAKKQYLIS 147
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 397 KLPAVLILHLKRFLyDDQAGGTLKNTKLISYPLRLEI-----PTRVISPGKRPLgpaRYQLTAVVYHHGLSaQGGHYTVD 471
Cdd:cd02667 148 KLPPVLVIHLKRFQ-QPRSANLRKVSRHVSFPEILDLapfcdPKCNSSEDKSSV---LYRLYGVVEHSGTM-RSGHYVAY 222
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 472 VHQH---------------------DGSSWIRIDDTTIRTISESdvEVTENEatvnssassdrcAYLLFY 520
Cdd:cd02667 223 VKVRppqqrlsdltkskpaadeagpGSGQWYYISDSDVREVSLE--EVLKSE------------AYLLFY 278
|
|
| COG5533 |
COG5533 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
161-522 |
7.58e-20 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444284 [Multi-domain] Cd Length: 284 Bit Score: 89.86 E-value: 7.58e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 161 GFVNTSNMCFMNSIFQALLYcvpfyvlmrnlgkKLPRLFRDKGSLLGSVITLTQEFRENWQPGEEEGDAYIPEVVyrVMK 240
Cdd:COG5533 1 GLPNLGNTCFMNSVLQILAL-------------YLPKLDELLDDLSKELKVLKNVIRKPEPDLNQEEALKLFTAL--WSS 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 241 NNPRFD-LVQTGEQEDAEEFLNLFLDEMHEEFVRTGNLEKAsspnadavdkdkedkeeegwlevgkkqkpvITRSATVSH 319
Cdd:COG5533 66 KEHKVGwIPPMGSQEDAHELLGKLLDELKLDLVNSFTIRIF------------------------------KTTKDKKKT 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 320 SpITEIFggqlrsvlkvpnardSVLLEPYQPLPLDIQPDhIHSVLDAMDHLTTPETLKGWRSPKGHTVTATKQ--VFIEK 397
Cdd:COG5533 116 S-TGDWF---------------DIIIELPDQTWVNNLKT-LQEFIDNMEELVDDETGVKAKENEELEVQAKQEyeVSFVK 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 398 LPAVLILHLKRFLYDdqaGGTLKNTKLISYPLRLEIPTRVISPGKRPLgpaRYQLTAVVYHHGlSAQGGHYTVDVHQhdG 477
Cdd:COG5533 179 LPKILTIQLKRFANL---GGNQKIDTEVDEKFELPVKHDQILNIVKET---YYDLVGFVLHQG-SLEGGHYIAYVKK--G 249
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 212001672 478 SSWIRIDDTTIRTISESDVevtENEATVNssassdrcAYLLFYTR 522
Cdd:COG5533 250 GKWEKANDSDVTPVSEEEA---INEKAKN--------AYLYFYER 283
|
|
| Peptidase_C19B |
cd02658 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
161-520 |
3.03e-18 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239123 [Multi-domain] Cd Length: 311 Bit Score: 85.45 E-value: 3.03e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 161 GFVNTSNMCFMNSIFQALLycvpfyvlmrNLGKKLPRLFRDKGSLLGSVITLTQEFRENW---------------QPGEE 225
Cdd:cd02658 1 GLRNLGNSCYLNSVLQVLF----------SIPSFQWRYDDLENKFPSDVVDPANDLNCQLikladgllsgryskpASLKS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 226 EGDAY---I-PEVVYRVM-KNNPRFdlvQTGEQEDAEEFLNLFLDEMHEEFVRTGNLEkassPNaDAVDkdkedkeeegw 300
Cdd:cd02658 71 ENDPYqvgIkPSMFKALIgKGHPEF---STMRQQDALEFLLHLIDKLDRESFKNLGLN----PN-DLFK----------- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 301 LEVGKKQKPVITRSATVSHSPITEIfggQLrSVLKVPNARDSVLLEPYQPLPLDiqpdhihsvlDAMDHLTTPETLKGWR 380
Cdd:cd02658 132 FMIEDRLECLSCKKVKYTSELSEIL---SL-PVPKDEATEKEEGELVYEPVPLE----------DCLKAYFAPETIEDFC 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 381 SPKGHTVTATKQVFIEKLPAVLILHLKRFLYddQAGGTlkntklisyPLRLEIPtrVISPGKrpLGPARYQLTAVVYHHG 460
Cdd:cd02658 198 STCKEKTTATKTTGFKTFPDYLVINMKRFQL--LENWV---------PKKLDVP--IDVPEE--LGPGKYELIAFISHKG 262
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 212001672 461 LSAQGGHYTVDVHQ--HDGSSWIRIDDTTIrTISESDVEVTENeatvnssassdrcAYLLFY 520
Cdd:cd02658 263 TSVHSGHYVAHIKKeiDGEGKWVLFNDEKV-VASQDPPEMKKL-------------GYIYFY 310
|
|
| Peptidase_C19F |
cd02662 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
161-520 |
4.73e-18 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239127 [Multi-domain] Cd Length: 240 Bit Score: 83.57 E-value: 4.73e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 161 GFVNTSNMCFMNSIFQALLYCvpfyvlmrnlgkklprlfrdkgsllgsvitltQEFREnwqpgeeegdaYIPEVVyrvmk 240
Cdd:cd02662 1 GLVNLGNTCFMNSVLQALASL--------------------------------PSLIE-----------YLEEFL----- 32
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 241 nnprfdlvqtgEQEDAEEFLNLFLDEMHEEFvrtgnlekaSSPnadavdkdkedkeeegwLEVGKKQKPVITRSATVSHS 320
Cdd:cd02662 33 -----------EQQDAHELFQVLLETLEQLL---------KFP-----------------FDGLLASRIVCLQCGESSKV 75
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 321 PITEIFGGQLRsvlkVPNARDsvllepyqplpldiqpDHIHSVLDAMDHLTTPETLKGWRSPKghtvtatKQVFIEKLPA 400
Cdd:cd02662 76 RYESFTMLSLP----VPNQSS----------------GSGTTLEHCLDDFLSTEIIDDYKCDR-------CQTVIVRLPQ 128
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 401 VLILHLKRFLYDDQaGGTLKNTKLISYPLRLEIPtrvispgkrplgpaRYQLTAVVYHHGlSAQGGHYTVDVHQHD---- 476
Cdd:cd02662 129 ILCIHLSRSVFDGR-GTSTKNSCKVSFPERLPKV--------------LYRLRAVVVHYG-SHSSGHYVCYRRKPLfskd 192
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 477 ----------------GSSWIRIDDTTIRTISESDVevteneatVNSSAssdrcAYLLFY 520
Cdd:cd02662 193 kepgsfvrmregpsstSHPWWRISDTTVKEVSESEV--------LEQKS-----AYMLFY 239
|
|
| Peptidase_C19L |
cd02668 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
250-521 |
1.60e-15 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239133 [Multi-domain] Cd Length: 324 Bit Score: 77.46 E-value: 1.60e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 250 TGEQEDAEEFLNLFLDEMHEEfvrtgnLEKASSPNADAVdkdkedkeeegwlevgkkqkpvitrsatvshspITEIFGGQ 329
Cdd:cd02668 85 TGQQQDAQEFSKLFLSLLEAK------LSKSKNPDLKNI---------------------------------VQDLFRGE 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 330 LRSVLK-VPNARDSVLLEPYQPLPLDIQpdhIHSVL-DAMDHLTTPETLKG---WRSPK-GHTVTATKQVFIEKLPAVLI 403
Cdd:cd02668 126 YSYVTQcSKCGRESSLPSKFYELELQLK---GHKTLeECIDEFLKEEQLTGdnqYFCEScNSKTDATRRIRLTTLPPTLN 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 404 LHLKRFLYDDQAGGTLKNTKLISYPLRLEIpTRVISPgkRPLGPARYQLTAVVYHHGLSAQGGHYTVDVHQHDGSSWIRI 483
Cdd:cd02668 203 FQLLRFVFDRKTGAKKKLNASISFPEILDM-GEYLAE--SDEGSYVYELSGVLIHQGVSAYSGHYIAHIKDEQTGEWYKF 279
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 212001672 484 DDTTIRTISESDVEVTENEATVNSSAS-------SDRCAYLLFYT 521
Cdd:cd02668 280 NDEDVEEMPGKPLKLGNSEDPAKPRKSeikkgthSSRTAYMLVYK 324
|
|
| Peptidase_C19O |
cd02671 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
149-520 |
1.16e-14 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239136 [Multi-domain] Cd Length: 332 Bit Score: 75.31 E-value: 1.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 149 PCIVKKTNIQP-RGFVNTSNMCFMNSIFQALLYCVPFYVLMRNLGkklprlfrdkgSLLGSVITLTQEFRENWQPGEEEG 227
Cdd:cd02671 13 TSCEKRENLLPfVGLNNLGNTCYLNSVLQVLYFCPGFKHGLKHLV-----------SLISSVEQLQSSFLLNPEKYNDEL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 228 DAYIPEVVYRVMKN-NPRFDLVQtgeQEDAEEFLNLFLDEMHEEFvrtgnlekasspnadavdkdkedkeeeGWLEVGKk 306
Cdd:cd02671 82 ANQAPRRLLNALREvNPMYEGYL---QHDAQEVLQCILGNIQELV---------------------------EKDFQGQ- 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 307 qkpVITRSATVSHSPITEIFGGQLRSVLKVPNARDSVLLEPYqplplDIQPD---HIHSVLDAMDHLTTPETLKG---WR 380
Cdd:cd02671 131 ---LVLRTRCLECETFTERREDFQDISVPVQESELSKSEESS-----EISPDpktEMKTLKWAISQFASVERIVGedkYF 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 381 SPKGHTVT-ATKQVFIEKLPAVLILHLKRF----LYDDQAGGTLKNTKLISYPLRLEIPTRVISPgKRPLgparYQLTAV 455
Cdd:cd02671 203 CENCHHYTeAERSLLFDKLPEVITIHLKCFaangSEFDCYGGLSKVNTPLLTPLKLSLEEWSTKP-KNDV----YRLFAV 277
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212001672 456 VYHHGLSAQGGHYTVDVhqhdgsSWIRIDDTTIRTISESDVevtenEATVNSSASSDRCAYLLFY 520
Cdd:cd02671 278 VMHSGATISSGHYTAYV------RWLLFDDSEVKVTEEKDF-----LEALSPNTSSTSTPYLLFY 331
|
|
| UBP12 |
COG5560 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
365-523 |
1.35e-13 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227847 [Multi-domain] Cd Length: 823 Bit Score: 73.76 E-value: 1.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 365 DAMDHLTTPETL---KGWRSP--KGHTvTATKQVFIEKLPAVLILHLKRFLYDDQAggTLKNTKLISYPL-RLEIPTRVI 438
Cdd:COG5560 679 DCLNEFSKPEQLglsDSWYCPgcKEFR-QASKQMELWRLPMILIIHLKRFSSVRSF--RDKIDDLVEYPIdDLDLSGVEY 755
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 439 SPGKRPLGparYQLTAVVYHHGLSAqGGHYTVDVHQHDGSSWIRIDDTTIRTISESDvevteneaTVNSSassdrcAYLL 518
Cdd:COG5560 756 MVDDPRLI---YDLYAVDNHYGGLS-GGHYTAYARNFANNGWYLFDDSRITEVDPED--------SVTSS------AYVL 817
|
....*
gi 212001672 519 FYTRC 523
Cdd:COG5560 818 FYRRK 822
|
|
| Peptidase_C19H |
cd02664 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
161-520 |
1.22e-12 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239129 [Multi-domain] Cd Length: 327 Bit Score: 69.06 E-value: 1.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 161 GFVNTSNMCFMNSIFQALLYCVPF--YVLMRNLGKKLPRLFRDKgSLLGSVITLTQEFRENWQPGEEEGDAYIPEVVyrv 238
Cdd:cd02664 1 GLINLGNTCYMNSVLQALFMAKDFrrQVLSLNLPRLGDSQSVMK-KLQLLQAHLMHTQRRAEAPPDYFLEASRPPWF--- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 239 mknNPRFdlvqtgeQEDAEEFLNLFLDEMHeefvrtgnlekasspnadavdkdkedkeeegwlevgkkqkpvitrsatvs 318
Cdd:cd02664 77 ---TPGS-------QQDCSEYLRYLLDRLH-------------------------------------------------- 96
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 319 hSPITEIFGGQLRSVLKVPNARD-SVLLEPYQPLPLDIQpdhihSVLDAMDHLTTPETLKG---WRSPKGHTV-TATKQV 393
Cdd:cd02664 97 -TLIEKMFGGKLSTTIRCLNCNStSARTERFRDLDLSFP-----SVQDLLNYFLSPEKLTGdnqYYCEKCASLqDAEKEM 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 394 FIEKLPAVLILHLKRFLYDDQAGGTLKNTKLISYPLRLEIPTRVISPGKRPLG----------------PARYQLTAVVY 457
Cdd:cd02664 171 KVTGAPEYLILTLLRFSYDQKTHVREKIMDNVSINEVLSLPVRVESKSSESPLekkeeesgddgelvtrQVHYRLYAVVV 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 458 HHGLSAQGGHY--------TVDVHQHDGS------------SWIRIDDTtirTISESDVEVTENeatVNSSASSDrCAYL 517
Cdd:cd02664 251 HSGYSSESGHYftyardqtDADSTGQECPepkdaeendeskNWYLFNDS---RVTFSSFESVQN---VTSRFPKD-TPYI 323
|
...
gi 212001672 518 LFY 520
Cdd:cd02664 324 LFY 326
|
|
| Peptidase_C19A |
cd02657 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
161-520 |
1.35e-11 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239122 [Multi-domain] Cd Length: 305 Bit Score: 65.43 E-value: 1.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 161 GFVNTSNMCFMNSIFQALlYCVPfyvlmrNLGKKLPRLFRDKGSLLGSVITLTQEFRENWQPGEEEGDAYIPEVVYRVM- 239
Cdd:cd02657 1 GLTNLGNTCYLNSTLQCL-RSVP------ELRDALKNYNPARRGANQSSDNLTNALRDLFDTMDKKQEPVPPIEFLQLLr 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 240 KNNPRFdlVQTGE-----QEDAEEFLNlfldemheEFVRTGNLEkasspnadavdkdkedkeeegwLEVGKKQKPVITRs 314
Cdd:cd02657 74 MAFPQF--AEKQNqggyaQQDAEECWS--------QLLSVLSQK----------------------LPGAGSKGSFIDQ- 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 315 atvshspiteIFGGQLRSVLKVPNARD--SVLLEPYQPLPLDIQPDHIHSVLDAMDHLTTPETLKGWRSPKGHTVTATKQ 392
Cdd:cd02657 121 ----------LFGIELETKMKCTESPDeeEVSTESEYKLQCHISITTEVNYLQDGLKKGLEEEIEKHSPTLGRDAIYTKT 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 393 VFIEKLPAVLILHLKRFLYDDQAGGTLKNTKLISYPLRLEIpTRVISPGkrplgpARYQLTAVVYHHGLSAQGGHYTVDV 472
Cdd:cd02657 191 SRISRLPKYLTVQFVRFFWKRDIQKKAKILRKVKFPFELDL-YELCTPS------GYYELVAVITHQGRSADSGHYVAWV 263
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 212001672 473 HQHDGSSWIRIDDttirtiseSDV-EVTENEATVNSSASSDRCAYLLFY 520
Cdd:cd02657 264 RRKNDGKWIKFDD--------DKVsEVTEEDILKLSGGGDWHIAYILLY 304
|
|
| Peptidase_C19M |
cd02669 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
145-500 |
8.08e-11 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239134 [Multi-domain] Cd Length: 440 Bit Score: 64.26 E-value: 8.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 145 KQFVPCIVKKTNIQPRGFVNtsnmcfmnSIFQALLYCVPFyvlmRN---LGKKLPRLFRDKGSLLGSVITLTqefRENWQ 221
Cdd:cd02669 113 KPYLPGFVGLNNIKNNDYAN--------VIIQALSHVKPI----RNfflLYENYENIKDRKSELVKRLSELI---RKIWN 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 222 PGEEEGDAYIPEVVYRVMK-NNPRFdlvQTGEQEDAEEFLNLFLDEMHEEfvrtgnLEKASSPNADAVDKDKEdkeeeGW 300
Cdd:cd02669 178 PRNFKGHVSPHELLQAVSKvSKKKF---SITEQSDPVEFLSWLLNTLHKD------LGGSKKPNSSIIHDCFQ-----GK 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 301 LEVgKKQKpvITRSATVSHSpiteifggqlRSVLKVPNARDSVLLEPYQPLPLDIQPDHIHSvlDAMDHLTTP-----ET 375
Cdd:cd02669 244 VQI-ETQK--IKPHAEEEGS----------KDKFFKDSRVKKTSVSPFLLLTLDLPPPPLFK--DGNEENIIPqvplkQL 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 376 LKGWRSPKGHTVTATKQVF-IEKLPAVLILHLKRFlyDDQAGGTLKNTKLISYPLRLEIPTRVISPGKRPLGP-ARYQLT 453
Cdd:cd02669 309 LKKYDGKTETELKDSLKRYlISRLPKYLIFHIKRF--SKNNFFKEKNPTIVNFPIKNLDLSDYVHFDKPSLNLsTKYNLV 386
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 212001672 454 AVVYHHGLSAQGGHYTVDVHQHDGSSWIRIDDTTIRTISESDVEVTE 500
Cdd:cd02669 387 ANIVHEGTPQEDGTWRVQLRHKSTNKWFEIQDLNVKEVLPQLIFLSE 433
|
|
| Peptidase_C19Q |
cd02673 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
395-520 |
8.89e-09 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239138 [Multi-domain] Cd Length: 245 Bit Score: 56.38 E-value: 8.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 395 IEKLPAVLILHLKRFLYDDQAGGTLKNTKLISYPLRLEIPTrvispgkrplgparYQLTAVVYHHGLSAQGGHY-TVDVH 473
Cdd:cd02673 143 IMTFPECLSINLKRYKLRIATSDYLKKNEEIMKKYCGTDAK--------------YSLVAVICHLGESPYDGHYiAYTKE 208
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 212001672 474 QHDGSSWIRIDDTTIRTISESDVevteneatvnsSASSDRCAYLLFY 520
Cdd:cd02673 209 LYNGSSWLYCSDDEIRPVSKNDV-----------STNARSSGYLIFY 244
|
|
| COG5077 |
COG5077 |
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ... |
161-496 |
9.57e-08 |
|
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227409 [Multi-domain] Cd Length: 1089 Bit Score: 54.88 E-value: 9.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 161 GFVNTSNMCFMNSIFQALLYCVPFyvlmRNLGKKLPRlfrDKGSLLGSVITLTQEFRENWQPGEEegdayiPEVVYRVMK 240
Cdd:COG5077 195 GLRNQGATCYMNSLLQSLFFIAKF----RKDVYGIPT---DHPRGRDSVALALQRLFYNLQTGEE------PVDTTELTR 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 241 NNPRFDLVQTgEQEDAEEFLNLFLDemheefvrtgNLEKasspnadavdkdkedkeeegwlevgKKQKpvitrsaTVSHS 320
Cdd:COG5077 262 SFGWDSDDSF-MQHDIQEFNRVLQD----------NLEK-------------------------SMRG-------TVVEN 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 321 PITEIFGGQLRSVLKVPNA-RDSVLLEPYQPLPLDIQpdHIHSVLDAMDHLTTPETLKG---WRSPKGHTVTATKQVFIE 396
Cdd:COG5077 299 ALNGIFVGKMKSYIKCVNVnYESARVEDFWDIQLNVK--GMKNLQESFRRYIQVETLDGdnrYNAEKHGLQDAKKGVIFE 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 397 KLPAVLILHLKRFLYDDQAGGTLKNTKLISYPLRLEIPTRVISPGKRPL-GPARYQLTAVVYHHGlSAQGGHYTVDVHQH 475
Cdd:COG5077 377 SLPPVLHLQLKRFEYDFERDMMVKINDRYEFPLEIDLLPFLDRDADKSEnSDAVYVLYGVLVHSG-DLHEGHYYALLKPE 455
|
330 340
....*....|....*....|.
gi 212001672 476 DGSSWIRIDDTTIRTISESDV 496
Cdd:COG5077 456 KDGRWYKFDDTRVTRATEKEV 476
|
|
| Peptidase_C19I |
cd02665 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
382-520 |
1.27e-05 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239130 [Multi-domain] Cd Length: 228 Bit Score: 46.40 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 382 PKGHTVTATKQVFIEKLPAVLILHLKRFLYDDQAGGTLKNtklisyplRLEIPtrvispgkRPLGPARYQLTAVVYHHGl 461
Cdd:cd02665 112 PSDHSVKSGQERWFTELPPVLTFELSRFEFNQGRPEKIHD--------KLEFP--------QIIQQVPYELHAVLVHEG- 174
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 212001672 462 SAQGGHYTVDVHQHDGSSWIRIDDttiRTISESDVEVTENEATVNSSASSdrcAYLLFY 520
Cdd:cd02665 175 QANAGHYWAYIYKQSRQEWEKYND---ISVTESSWEEVERDSFGGGRNPS---AYCLMY 227
|
|
| UBP12 |
COG5560 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
161-359 |
3.51e-05 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227847 [Multi-domain] Cd Length: 823 Bit Score: 46.80 E-value: 3.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 161 GFVNTSNMCFMNSIFQALLYCVPF--YVLMRNLGKKLPRlfrdkGSLLGSVITLTQEFRENWQPGEEEGDAYIPEVVYRv 238
Cdd:COG5560 267 GLRNLGNTCYMNSALQCLMHTWELrdYFLSDEYEESINE-----ENPLGMHGSVASAYADLIKQLYDGNLHAFTPSGFK- 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 239 mKNNPRFDLVQTG-EQEDAEEFLNLFLDEMHEEFVRTGNLEKASSPNADAVDKdkedkeeegwLEVGKKQKPVITRSATV 317
Cdd:COG5560 341 -KTIGSFNEEFSGyDQQDSQEFIAFLLDGLHEDLNRIIKKPYTSKPDLSPGDD----------VVVKKKAKECWWEHLKR 409
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 212001672 318 SHSPITEIFGGQLRSVLKVPNARD-SVLLEPYQ----PLPLDIQPDH 359
Cdd:COG5560 410 NDSIITDLFQGMYKSTLTCPGCGSvSITFDPFMdltlPLPVSMVWKH 456
|
|
| UCH_1 |
pfam13423 |
Ubiquitin carboxyl-terminal hydrolase; |
316-485 |
2.16e-04 |
|
Ubiquitin carboxyl-terminal hydrolase;
Pssm-ID: 463872 [Multi-domain] Cd Length: 305 Bit Score: 43.41 E-value: 2.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 316 TVSHSPITEIFGGQLRSVLKVPN-----ARDSV-----LLEPYQPLPLDIQPdHIHSVLDAMDHLTTPETL-KGW-RSPK 383
Cdd:pfam13423 122 SPAESPLEQLFGIDAETTIRCSNcghesVRESSthvldLIYPRKPSSNNKKP-PNQTFSSILKSSLERETTtKAWcEKCK 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212001672 384 GHTVTATKQVfIEKLPAVLILHLKrfLYDDQAGGTLKNTKLIsyPLRLEIPTRVISPGKRPLgpARYQLTAVVYHHGLSA 463
Cdd:pfam13423 201 RYQPLESRRT-VRNLPPVLSLNAA--LTNEEWRQLWKTPGWL--PPEIGLTLSDDLQGDNEI--VKYELRGVVVHIGDSG 273
|
170 180
....*....|....*....|....*....
gi 212001672 464 QGGHY--TVDV----HQHDG-SSWIRIDD 485
Cdd:pfam13423 274 TSGHLvsFVKVadseLEDPTeSQWYLFND 302
|
|
| |
