NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|530775254|gb|EEB05496|]
View 

nuclear distribution protein nudF [Schizosaccharomyces japonicus yFS275]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
94-437 1.01e-68

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 224.02  E-value: 1.01e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254  94 ATKEIWLPQKDDEVELLGHRSPITALAFHPYITVVASASEDAKIKIWDCDTNSLETTLVGHFKSIRALAFSETtGNeqek 173
Cdd:COG2319   59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD-GK---- 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 174 vYLASGAEDATICLWDATSGyANLYALTGHEATVSCIRFLkeHDGpLLLLSGSKDGSVRLWDVETGECVRVFNQfGSQWV 253
Cdd:COG2319  134 -TLASGSADGTVRLWDLATG-KLLRTLTGHSGAVTSVAFS--PDG-KLLASGSDDGTVRLWDLATGKLLRTLTG-HTGAV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 254 RALAVFEDKEHFVAAGNDGKARVLDLRNESARPILcTGHSHVIECVEVLPStaypyvqkffGREVAarqetlsrllflTG 333
Cdd:COG2319  208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL-TGHSGSVRSVAFSPD----------GRLLA------------SG 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 334 SRDNKIFLWDGATGKLLHKFEGHKNWVHSITFHPCGKYFLSVSDDRTMKIWDLEGGQAVETISFQNRIPLCVCWkHPMSS 413
Cdd:COG2319  265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF-SPDGK 343

                        330       340
                 ....*....|....*....|....
gi 530775254 414 TdvlqnylnlFASGCSDSHIQIWS 437
Cdd:COG2319  344 T---------LASGSDDGTVRLWD 358
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
94-437 1.01e-68

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 224.02  E-value: 1.01e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254  94 ATKEIWLPQKDDEVELLGHRSPITALAFHPYITVVASASEDAKIKIWDCDTNSLETTLVGHFKSIRALAFSETtGNeqek 173
Cdd:COG2319   59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD-GK---- 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 174 vYLASGAEDATICLWDATSGyANLYALTGHEATVSCIRFLkeHDGpLLLLSGSKDGSVRLWDVETGECVRVFNQfGSQWV 253
Cdd:COG2319  134 -TLASGSADGTVRLWDLATG-KLLRTLTGHSGAVTSVAFS--PDG-KLLASGSDDGTVRLWDLATGKLLRTLTG-HTGAV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 254 RALAVFEDKEHFVAAGNDGKARVLDLRNESARPILcTGHSHVIECVEVLPStaypyvqkffGREVAarqetlsrllflTG 333
Cdd:COG2319  208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL-TGHSGSVRSVAFSPD----------GRLLA------------SG 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 334 SRDNKIFLWDGATGKLLHKFEGHKNWVHSITFHPCGKYFLSVSDDRTMKIWDLEGGQAVETISFQNRIPLCVCWkHPMSS 413
Cdd:COG2319  265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF-SPDGK 343

                        330       340
                 ....*....|....*....|....
gi 530775254 414 TdvlqnylnlFASGCSDSHIQIWS 437
Cdd:COG2319  344 T---------LASGSDDGTVRLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 108-437 1.84e-68

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 219.51  E-value: 1.84e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 108 ELLGHRSPITALAFHPYITVVASASEDAKIKIWDCDTNSLETTLVGHFKSIRALAFSETTGneqekvYLASGAEDATICL 187
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGT------YLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 188 WDATSGyANLYALTGHEATVSCIRFLKEHDgplLLLSGSKDGSVRLWDVETGECVRVFNQFgSQWVRALAVFEDKEHFVA 267
Cdd:cd00200   78 WDLETG-ECVRTLTGHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVAS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 268 AGNDGKARVLDLRNESARPILcTGHSHVIECVEVLPStaypyvqkffgrevaarqetlsRLLFLTGSRDNKIFLWDGATG 347
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSPD----------------------GEKLLSSSSDGTIKLWDLSTG 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 348 KLLHKFEGHKNWVHSITFHPCGKYFLSVSDDRTMKIWDLEGGQAVETIS-FQNRIpLCVCWkHPMSSTdvlqnylnlFAS 426
Cdd:cd00200  210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSgHTNSV-TSLAW-SPDGKR---------LAS 278

                        330
                 ....*....|.
gi 530775254 427 GCSDSHIQIWS 437
Cdd:cd00200  279 GSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-419 5.03e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 68.19  E-value: 5.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 108 ELLGHRSPITALAFHPYITVVASASEDAKIKIWDCDTNSLETTLVgHFKSIRALAFSETTG---NEQEKVYLASGAEDAT 184
Cdd:PLN00181 478 DLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDI-HYPVVELASRSKLSGicwNSYIKSQVASSNFEGV 556

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 185 ICLWDATSGYAnLYALTGHEATVSCIRFlkEHDGPLLLLSGSKDGSVRLWDVETGECVRVFN--------QFGSQWVRAL 256
Cdd:PLN00181 557 VQVWDVARSQL-VTEMKEHEKRVWSIDY--SSADPTLLASGSDDGSVKLWSINQGVSIGTIKtkaniccvQFPSESGRSL 633

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 257 AvFEDKEHfvaagndgKARVLDLRNesARPILCT--GHSHVIECVEVLPSTAypyvqkffgrevaarqetlsrllFLTGS 334
Cdd:PLN00181 634 A-FGSADH--------KVYYYDLRN--PKLPLCTmiGHSKTVSYVRFVDSST-----------------------LVSSS 679

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 335 RDNKIFLWD------GATGKLLHKFEGHKNWVHSITFHPCGKYFLSVSDDRTMKIWDLEGGQAVETISFQNRIPL----- 403
Cdd:PLN00181 680 TDNTLKLWDlsmsisGINETPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKTIDPVsglev 759

                        330       340
                 ....*....|....*....|....
gi 530775254 404 --------CVCWKHpMSSTDVLQN 419
Cdd:PLN00181 760 ddasqfisSVCWRG-QSSTLVAAN 782
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 346-385 3.16e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 57.71  E-value: 3.16e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530775254   346 TGKLLHKFEGHKNWVHSITFHPCGKYFLSVSDDRTMKIWD 385
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
347-385 4.08e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.66  E-value: 4.08e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530775254  347 GKLLHKFEGHKNWVHSITFHPCGKYFLSVSDDRTMKIWD 385
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
94-437 1.01e-68

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 224.02  E-value: 1.01e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254  94 ATKEIWLPQKDDEVELLGHRSPITALAFHPYITVVASASEDAKIKIWDCDTNSLETTLVGHFKSIRALAFSETtGNeqek 173
Cdd:COG2319   59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD-GK---- 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 174 vYLASGAEDATICLWDATSGyANLYALTGHEATVSCIRFLkeHDGpLLLLSGSKDGSVRLWDVETGECVRVFNQfGSQWV 253
Cdd:COG2319  134 -TLASGSADGTVRLWDLATG-KLLRTLTGHSGAVTSVAFS--PDG-KLLASGSDDGTVRLWDLATGKLLRTLTG-HTGAV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 254 RALAVFEDKEHFVAAGNDGKARVLDLRNESARPILcTGHSHVIECVEVLPStaypyvqkffGREVAarqetlsrllflTG 333
Cdd:COG2319  208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL-TGHSGSVRSVAFSPD----------GRLLA------------SG 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 334 SRDNKIFLWDGATGKLLHKFEGHKNWVHSITFHPCGKYFLSVSDDRTMKIWDLEGGQAVETISFQNRIPLCVCWkHPMSS 413
Cdd:COG2319  265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF-SPDGK 343

                        330       340
                 ....*....|....*....|....
gi 530775254 414 TdvlqnylnlFASGCSDSHIQIWS 437
Cdd:COG2319  344 T---------LASGSDDGTVRLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 108-437 1.84e-68

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 219.51  E-value: 1.84e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 108 ELLGHRSPITALAFHPYITVVASASEDAKIKIWDCDTNSLETTLVGHFKSIRALAFSETTGneqekvYLASGAEDATICL 187
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGT------YLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 188 WDATSGyANLYALTGHEATVSCIRFLKEHDgplLLLSGSKDGSVRLWDVETGECVRVFNQFgSQWVRALAVFEDKEHFVA 267
Cdd:cd00200   78 WDLETG-ECVRTLTGHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVAS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 268 AGNDGKARVLDLRNESARPILcTGHSHVIECVEVLPStaypyvqkffgrevaarqetlsRLLFLTGSRDNKIFLWDGATG 347
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSPD----------------------GEKLLSSSSDGTIKLWDLSTG 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 348 KLLHKFEGHKNWVHSITFHPCGKYFLSVSDDRTMKIWDLEGGQAVETIS-FQNRIpLCVCWkHPMSSTdvlqnylnlFAS 426
Cdd:cd00200  210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSgHTNSV-TSLAW-SPDGKR---------LAS 278

                        330
                 ....*....|.
gi 530775254 427 GCSDSHIQIWS 437
Cdd:cd00200  279 GSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
94-437 4.55e-68

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 222.09  E-value: 4.55e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254  94 ATKEIW-LPQKDDEVELLGHRSPITALAFHPYITVVASASEDAKIKIWDCDTNSLETTLVGHFKSIRALAFSeTTGNeqe 172
Cdd:COG2319  100 GTVRLWdLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-PDGK--- 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 173 kvYLASGAEDATICLWDATSGyANLYALTGHEATVSCIRFLkeHDGPLLLlSGSKDGSVRLWDVETGECVRVFnQFGSQW 252
Cdd:COG2319  176 --LLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFS--PDGKLLA-SGSADGTVRLWDLATGKLLRTL-TGHSGS 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 253 VRALAVFEDKEHFVAAGNDGKARVLDLRNESARPILcTGHSHVIECVEVLPStaypyvqkffGREVAarqetlsrllflT 332
Cdd:COG2319  249 VRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL-TGHSGGVNSVAFSPD----------GKLLA------------S 305

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 333 GSRDNKIFLWDGATGKLLHKFEGHKNWVHSITFHPCGKYFLSVSDDRTMKIWDLEGGQAVETISFQNRIPLCVCWkhpms 412
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF----- 380

                        330       340
                 ....*....|....*....|....*
gi 530775254 413 STDvlQNYLnlfASGCSDSHIQIWS 437
Cdd:COG2319  381 SPD--GRTL---ASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
108-388 3.64e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 214.78  E-value: 3.64e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 108 ELLGHRSPITALAFHP---YItvvASASEDAKIKIWDCDTNSLETTLVGHFKSIRALAFSeTTGNeqekvYLASGAEDAT 184
Cdd:COG2319  157 TLTGHSGAVTSVAFSPdgkLL---ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS-PDGK-----LLASGSADGT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 185 ICLWDATSGyANLYALTGHEATVSCIRFLkeHDGPLLLlSGSKDGSVRLWDVETGECVRVFnQFGSQWVRALAVFEDKEH 264
Cdd:COG2319  228 VRLWDLATG-KLLRTLTGHSGSVRSVAFS--PDGRLLA-SGSADGTVRLWDLATGELLRTL-TGHSGGVNSVAFSPDGKL 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 265 FVAAGNDGKARVLDLRNESARPILcTGHSHVIECVEVLPStaypyvqkffGREVAarqetlsrllflTGSRDNKIFLWDG 344
Cdd:COG2319  303 LASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPD----------GKTLA------------SGSDDGTVRLWDL 359

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 530775254 345 ATGKLLHKFEGHKNWVHSITFHPCGKYFLSVSDDRTMKIWDLEG 388
Cdd:COG2319  360 ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
109-437 5.51e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.20  E-value: 5.51e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 109 LLGHRSPITALAFHPYITVVASASEDAKIKIWDCDTNSLETTLVGHFKSIRALAFSETTGneqekvYLASGAEDATICLW 188
Cdd:COG2319   32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR------LLASASADGTVRLW 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 189 DATSGyANLYALTGHEATVSCIRFlkEHDGpLLLLSGSKDGSVRLWDVETGECVRVFNQfGSQWVRALAVFEDKEHFVAA 268
Cdd:COG2319  106 DLATG-LLLRTLTGHTGAVRSVAF--SPDG-KTLASGSADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASG 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 269 GNDGKARVLDLRNESARPILcTGHSHVIECVEVLPStaypyvqkffGREVAarqetlsrllflTGSRDNKIFLWDGATGK 348
Cdd:COG2319  181 SDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPD----------GKLLA------------SGSADGTVRLWDLATGK 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 349 LLHKFEGHKNWVHSITFHPCGKYFLSVSDDRTMKIWDLEGGQAVETISFQNRIPLCVCWkhpmsSTDvlqnyLNLFASGC 428
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF-----SPD-----GKLLASGS 307


                 ....*....
gi 530775254 429 SDSHIQIWS 437
Cdd:COG2319  308 DDGTVRLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
120-437 5.41e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.23  E-value: 5.41e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 120 AFHPYITVVASASEDAKIKIWDCDTNSLETTLVGHFKSIRALAFSETTGNeqekvyLASGAEDATICLWDATSGyANLYA 199
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGAR------LAAGAGDLTLLLLDAAAG-ALLAT 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 200 LTGHEATVSCIRFLkehDGPLLLLSGSKDGSVRLWDVETGECVRVFNQFGSqWVRALAVFEDKEHFVAAGNDGKARVLDL 279
Cdd:COG2319   74 LLGHTAAVLSVAFS---PDGRLLASASADGTVRLWDLATGLLLRTLTGHTG-AVRSVAFSPDGKTLASGSADGTVRLWDL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 280 RNESARPILcTGHSHVIECVEVLPStaypyvqkffGREVAarqetlsrllflTGSRDNKIFLWDGATGKLLHKFEGHKNW 359
Cdd:COG2319  150 ATGKLLRTL-TGHSGAVTSVAFSPD----------GKLLA------------SGSDDGTVRLWDLATGKLLRTLTGHTGA 206

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530775254 360 VHSITFHPCGKYFLSVSDDRTMKIWDLEGGQAVETISFQNRIPLCVCWkhpmsSTDVlqnylNLFASGCSDSHIQIWS 437
Cdd:COG2319  207 VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF-----SPDG-----RLLASGSADGTVRLWD 274
WD40 COG2319
WD40 repeat [General function prediction only];
221-445 4.89e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 4.89e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 221 LLLSGSKDGSVRLWDVETGECVRVFnQFGSQWVRALAVFEDKEHFVAAGNDGKARVLDLRNESARPILcTGHSHVIECVE 300
Cdd:COG2319    8 ALAAASADLALALLAAALGALLLLL-LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL-LGHTAAVLSVA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 301 VLPSTAYpyvqkffgrevaarqetlsrllFLTGSRDNKIFLWDGATGKLLHKFEGHKNWVHSITFHPCGKYFLSVSDDRT 380
Cdd:COG2319   86 FSPDGRL----------------------LASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530775254 381 MKIWDLEGGQAVETISFQNRIPLCVCWkHPMSSTdvlqnylnlFASGCSDSHIQIWSSHKSNPVQ 445
Cdd:COG2319  144 VRLWDLATGKLLRTLTGHSGAVTSVAF-SPDGKL---------LASGSDDGTVRLWDLATGKLLR 198
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-419 5.03e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 68.19  E-value: 5.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 108 ELLGHRSPITALAFHPYITVVASASEDAKIKIWDCDTNSLETTLVgHFKSIRALAFSETTG---NEQEKVYLASGAEDAT 184
Cdd:PLN00181 478 DLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDI-HYPVVELASRSKLSGicwNSYIKSQVASSNFEGV 556

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 185 ICLWDATSGYAnLYALTGHEATVSCIRFlkEHDGPLLLLSGSKDGSVRLWDVETGECVRVFN--------QFGSQWVRAL 256
Cdd:PLN00181 557 VQVWDVARSQL-VTEMKEHEKRVWSIDY--SSADPTLLASGSDDGSVKLWSINQGVSIGTIKtkaniccvQFPSESGRSL 633

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 257 AvFEDKEHfvaagndgKARVLDLRNesARPILCT--GHSHVIECVEVLPSTAypyvqkffgrevaarqetlsrllFLTGS 334
Cdd:PLN00181 634 A-FGSADH--------KVYYYDLRN--PKLPLCTmiGHSKTVSYVRFVDSST-----------------------LVSSS 679

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 335 RDNKIFLWD------GATGKLLHKFEGHKNWVHSITFHPCGKYFLSVSDDRTMKIWDLEGGQAVETISFQNRIPL----- 403
Cdd:PLN00181 680 TDNTLKLWDlsmsisGINETPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKTIDPVsglev 759

                        330       340
                 ....*....|....*....|....
gi 530775254 404 --------CVCWKHpMSSTDVLQN 419
Cdd:PLN00181 760 ddasqfisSVCWRG-QSSTLVAAN 782
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 346-385 3.16e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 57.71  E-value: 3.16e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530775254   346 TGKLLHKFEGHKNWVHSITFHPCGKYFLSVSDDRTMKIWD 385
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
347-385 4.08e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.66  E-value: 4.08e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530775254  347 GKLLHKFEGHKNWVHSITFHPCGKYFLSVSDDRTMKIWD 385
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 108-141 4.11e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 530775254   108 ELLGHRSPITALAFHPYITVVASASEDAKIKIWD 141
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
108-141 1.91e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.91e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530775254  108 ELLGHRSPITALAFHPYITVVASASEDAKIKIWD 141
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
197-235 3.98e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.98e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530775254  197 LYALTGHEATVSCIRFLKEHDgplLLLSGSKDGSVRLWD 235
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGK---LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 197-235 1.01e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.01e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 530775254   197 LYALTGHEATVSCIRFlkeHDGPLLLLSGSKDGSVRLWD 235
Cdd:smart00320   5 LKTLKGHTGPVTSVAF---SPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 329-396 2.22e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 2.22e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530775254 329 LFlTGSRDNKIFLWDGATGKL-------LHKFEGHKNWVHSITFHPCGKYFL-SVSDDRTMKIWDLEGGQAVETIS 396
Cdd:PTZ00421  91 LF-TASEDGTIMGWGIPEEGLtqnisdpIVHLQGHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVERGKAVEVIK 165
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 86-390 5.24e-05

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 44.91  E-value: 5.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254  86 LVKLQPYKATKEIWLPQKDDEVELLGHRSPITALAF--HPYITVVASASEDAKIKIWDCDTNSLETTlvghfksIRALAF 163
Cdd:cd22857    3 LVKVVEARGKQEEAAPKVVDRWGGPDKSKAVQALSIadRESEPLLAVARKNGTVEVLDPENGDLLAS-------FSDSEP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 164 SETTGNEQEKVYLAsgAEDATIcLWDATSGYANLYALTGHEATVS----------CIRFLKEHDGPLLLLSGSKDGSVRL 233
Cdd:cd22857   76 ATKLSEEDHFVGLH--LFSGTL-LTCTSKGSLRSTKLPDDSTASSsptawvclggNLLCMRVDPNENYFAFGGKEVELNV 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 234 WDVEtGECVRVF-------NQFGSQ---WVRALAvF---EDKEHFVAAGNDGKARVLDLRNESARPILCTGHSHVIECVE 300
Cdd:cd22857  153 WDLE-EKPGKIWraknvpnDSLGLRvpvWVTDLT-FlskDDHRKIVTGTGYHQVRLYDTRAQRRPVVSVDFGETPIKAVA 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 301 VLPStaypyvqkffGREVAArqetlsrllfltGSRDNKIFLWDGATGKLLHKFEGhKN--WVHSITFHPCGKYFLSVSDD 378
Cdd:cd22857  231 EDPD----------GHTVYV------------GDTSGDLASIDLRTGKLLGCFKG-KCggSIRSIARHPELPLIASCGLD 287

                        330
                 ....*....|..
gi 530775254 379 RTMKIWDLEGGQ 390
Cdd:cd22857  288 RYLRIWDTETRQ 299
PTZ00421 PTZ00421
coronin; Provisional
 109-242 5.69e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 5.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 109 LLGHRSPITALAFHPY-ITVVASASEDAKIKIWDCDTNSLETT-------LVGHFKSIRALAFSETTGNeqekvYLASGA 180
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPFdPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMN-----VLASAG 145

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530775254 181 EDATICLWDATSGYAnlyaltghEATVSC----IRFLKEHDGPLLLLSGSKDGSVRLWDVETGECV 242
Cdd:PTZ00421 146 ADMVVNVWDVERGKA--------VEVIKChsdqITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIV 203
PTZ00420 PTZ00420
coronin; Provisional
 107-189 1.23e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 1.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 107 VELLGHRSPITALAFHP-YITVVASASEDAKIKIWDC---DTNSLETT-----LVGHFKSIRALAFsettgNEQEKVYLA 177
Cdd:PTZ00420  68 IKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIphnDESVKEIKdpqciLKGHKKKISIIDW-----NPMNYYIMC 142

                         90
                 ....*....|..
gi 530775254 178 SGAEDATICLWD 189
Cdd:PTZ00420 143 SSGFDSFVNIWD 154
PTZ00421 PTZ00421
coronin; Provisional
 172-294 1.42e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.11  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530775254 172 EKVYLASgaEDATICLWD------ATSGYANLYALTGHEATVSCIRFLKEHDGplLLLSGSKDGSVRLWDVETGECVRVF 245
Cdd:PTZ00421  89 QKLFTAS--EDGTIMGWGipeeglTQNISDPIVHLQGHTKKVGIVSFHPSAMN--VLASAGADMVVNVWDVERGKAVEVI 164

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 530775254 246 NQFgSQWVRALAVFEDKEHFVAAGNDGKARVLDLRNESarpILCTGHSH 294
Cdd:PTZ00421 165 KCH-SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGT---IVSSVEAH 209
8prop_heme_binding_protein cd20718
eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; ...
 328-395 2.53e-04

eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; Members here contain an 8-bladed beta-propeller heme-binding domain in cytochrome cd1 (nitrite reductase) and similar proteins including NirN and NirF. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO(3-)-> NO(2-)-> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic nitrite reductase NirS via its maturation factor NirF. NirN and NirF form a stable complex with the nitrite reductase NirS during enzyme maturation. NirF is involved in heme d1 insertion.


Pssm-ID: 467720 [Multi-domain]  Cd Length: 380  Bit Score: 43.09  E-value: 2.53e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530775254 328 LLFLTGSRDNKIFLWDGATGKLLHKFEGHKNWVHSITFHPCGKYFLSVSDDRTMKIWDLEGGQAVETI 395
Cdd:cd20718   29 LMVVVERDAGSVLVIDGSTHEVLGRIDDGGAQVHVVVFSPDGRFAYVISRDGWLTKIDLYTLRPVASI 96
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 144-189 4.70e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 4.70e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 530775254   144 TNSLETTLVGHFKSIRALAFSETTGneqekvYLASGAEDATICLWD 189
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK------YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
145-189 6.15e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 6.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 530775254  145 NSLETTLVGHFKSIRALAFSettgneQEKVYLASGAEDATICLWD 189
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFS------PDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 104-161 1.31e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 1.31e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530775254 104 DDEVELLGHRSPITALAFHPY-ITVVASASEDAKIKIWDCDTNSLETTLVGHFKSIRAL 161
Cdd:PTZ00421 116 DPIVHLQGHTKKVGIVSFHPSaMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSL 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH