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Conserved domains on  [gi|149055143|gb|EDM06960|]
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rCG32649 [Rattus norvegicus]

Protein Classification

patched/dispatched family protein( domain architecture ID 1904021)

patched/dispatched family protein may be involved in hedgehog (Hh) signaling, similar to Drosophila melanogaster proteins patched and dispatched, that acts as a receptor for Hh and a regulator of Hh trafficking, respectively

Gene Ontology:  GO:0007165|GO:0016020
PubMed:  36932157|21778405

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Patched super family cl44384
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 2-539 1.71e-127

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


The actual alignment was detected with superfamily member pfam02460:

Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 391.33  E-value: 1.71e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143    2 WVAVFGVFSVAMSVVSGFGLMLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWQKTSLTESVSERLSNSYSKVAVSITI 81
Cdd:pfam02460 250 ILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSITI 329

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   82 TTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALDGKREV----VWSRWLEKPDQKYSSFkkfccv 157
Cdd:pfam02460 330 TSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAegrhCLFVWATSSPQRIDSE------ 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  158 pfGSFPDEHGDDNHPMNLFFRDYFGPFLTTSKAKFIVVLIYIFYIISSIYGCFQVQEGLDLRNLASDDSYITPYFNVEED 237
Cdd:pfam02460 404 --GSEPDKSHNIEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREK 481

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  238 YFSDYGPRVMVIVTETVNYWDKDVRQKLDKCMTQFEQNEY-VDKNLTEFWLEAYMQY---MNNTGNNPNDKNTFMNNIAG 313
Cdd:pfam02460 482 HFWPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYsLGPNSTLFWLREYENFlstLNMEEEEDEEKEWSYGNLPS 561

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  314 FLN--FFPVFTYDINVSSSN-EITSSRGFIQTIDVSSSSNKKRMLLKLRGIA-ENCEVPLMVYNQAFIYFDQYAAIIENT 389
Cdd:pfam02460 562 FLKapGNSHWAGDLVWDDNTtMVTKFRFTLAGKGLSTWNDRTRALQEWRSIAdQYPEFNVTVFDEDAPFADQYLTILPST 641

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  390 VRNVMIASTAMFIVSLLLIPHPVCSLWVTFAIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDFSAHISYAFVSSN 469
Cdd:pfam02460 642 IQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSR 721

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  470 EPSVNKKSIEALYLLGYPVLQSAISTIIGVCVLAAAKAYIFRTFFKIMFLVMFFGAAHGLIFIPVFLTFF 539
Cdd:pfam02460 722 GDTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIILSLF 791
 
Name Accession Description Interval E-value
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 2-539 1.71e-127

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 391.33  E-value: 1.71e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143    2 WVAVFGVFSVAMSVVSGFGLMLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWQKTSLTESVSERLSNSYSKVAVSITI 81
Cdd:pfam02460 250 ILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSITI 329

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   82 TTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALDGKREV----VWSRWLEKPDQKYSSFkkfccv 157
Cdd:pfam02460 330 TSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAegrhCLFVWATSSPQRIDSE------ 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  158 pfGSFPDEHGDDNHPMNLFFRDYFGPFLTTSKAKFIVVLIYIFYIISSIYGCFQVQEGLDLRNLASDDSYITPYFNVEED 237
Cdd:pfam02460 404 --GSEPDKSHNIEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREK 481

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  238 YFSDYGPRVMVIVTETVNYWDKDVRQKLDKCMTQFEQNEY-VDKNLTEFWLEAYMQY---MNNTGNNPNDKNTFMNNIAG 313
Cdd:pfam02460 482 HFWPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYsLGPNSTLFWLREYENFlstLNMEEEEDEEKEWSYGNLPS 561

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  314 FLN--FFPVFTYDINVSSSN-EITSSRGFIQTIDVSSSSNKKRMLLKLRGIA-ENCEVPLMVYNQAFIYFDQYAAIIENT 389
Cdd:pfam02460 562 FLKapGNSHWAGDLVWDDNTtMVTKFRFTLAGKGLSTWNDRTRALQEWRSIAdQYPEFNVTVFDEDAPFADQYLTILPST 641

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  390 VRNVMIASTAMFIVSLLLIPHPVCSLWVTFAIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDFSAHISYAFVSSN 469
Cdd:pfam02460 642 IQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSR 721

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  470 EPSVNKKSIEALYLLGYPVLQSAISTIIGVCVLAAAKAYIFRTFFKIMFLVMFFGAAHGLIFIPVFLTFF 539
Cdd:pfam02460 722 GDTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIILSLF 791
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 7-539 1.38e-52

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 193.20  E-value: 1.38e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143     7 GVFSVAMSVVSGFGLMLHIGVPFVIIVANS-PFLILGVGVDDMFIMISAWQ-----------KTSLTESVSERLSNSYSK 74
Cdd:TIGR00917  613 GILIVMLSVLGSVGVFSAVGLKSTLIIMEViPFLVLAVGVDNIFILVFFYFyleyfyrqvgvDNEQELTLERRLSRALME 692

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143    75 VAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALDGKRevvwsrwlekpdQKYSSFKKF 154
Cdd:TIGR00917  693 VGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKR------------TEDKRVDCF 760

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   155 CCVPF--GSFPDEHGDDNHPMNL---FFRDYFGPFLTTSKAKFIVVLIYIFYIISSIYGCFQVQEGLDLRNLASDDSYIT 229
Cdd:TIGR00917  761 PCIKTskSSISAEKGSGQRKAGLltrYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQ 840

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   230 PYFNVEEDYFsDYGPRVMVIVTETVNYWDKDVRQKL--------DKCMTQFEQNEYVDKNLTEfWLEAYMQYM------- 294
Cdd:TIGR00917  841 IYFASLTPLL-EVGPPFYIVIKGDYNYTDFESQNKLctmggcdkDSIVNVFNNLSYIAKPASS-WLDDYLVWLspqascc 918

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   295 ---NNTG---NNPNDK----NTFMNNIAG------FLNFFPVFTYDIN-----------VSSSNEITSSRGFIQ------ 341
Cdd:TIGR00917  919 crkFTNGtfcNGPDPQcfrcADLSSDAQGrpsttqFKEKLPWFLNALPsadcakgghaaYSSAVDLQGYATIIQassfrt 998

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   342 -------TIDVSSSSNKKRMLLKlrGIAENCEVPLMVYNQAFIYFDQYAAIIENTVRNVMIASTAMFIVSLLLIPhpvCS 414
Cdd:TIGR00917  999 yhtplntQVDFINAMRAAQEFAA--KVSRSSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQ---LN 1073

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   415 LWVTF----AIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDFSAHISYAFVSSNEPSVNKKSIEALYLLGYPVLQ 490
Cdd:TIGR00917 1074 ALSVVnlimSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFS 1153

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|.
gi 149055143   491 S-AISTIIGVCVLAAAKAYIFRTFFKIMFLVM-FFGAAHGLIFIPVFLTFF 539
Cdd:TIGR00917 1154 GiTLTKLVGVVVLGFSRSEIFVVYYFRMYLALvLLGFLHGLVFLPVLLSVL 1204
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
2-539 6.37e-20

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 93.77  E-value: 6.37e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   2 WVAVFGVFSVAMSVVSGFGLMLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWQK-TSLTESVSERLSNSYSKVAVSIT 80
Cdd:COG1033  243 RGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREeRRKGLDKREALREALRKLGPPVL 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  81 ITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALdgkrevvwsrwLEKPDQKYSSFKKfccvpfg 160
Cdd:COG1033  323 LTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSL-----------LPRPKPKTRRLKK------- 384

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143 161 sfpdeHGDDNHPMNLFFRdyfgpflTTSKAKFIVVLIYIFYIISSIYGCFQVQ-EGLDLRNLASDDSYITPYFNVEEDYF 239
Cdd:COG1033  385 -----PPELGRLLAKLAR-------FVLRRPKVILVVALVLAVVSLYGISRLKvEYDFEDYLPEDSPIRQDLDFIEENFG 452

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143 240 SDYGPRVMVIVTETVNYWDKDVRQKLDKCMTQFEQNEYVDKNLTefwLEAYMQYMNNTGNNPNDKNTFMNNIAGFLNFFP 319
Cdd:COG1033  453 GSDPLEVVVDTGEPDGLKDPEVLKEIDRLQDYLESLPEVGKVLS---LADLVKELNQALNEGDPKYYALPESRELLAQLL 529

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143 320 VFTYDINVSSSNEITS---SRGFIQ-TIDVSSSSNKKRMLLKLR-GIAENCEVPLMVYN---QAFIYFDQYAAIIENTVR 391
Cdd:COG1033  530 LLLSSPPGDDLSRFVDedySAARVTvRLKDLDSEEIKALVEEVRaFLAENFPPDGVEVTltgSAVLFAAINESVIESQIR 609

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143 392 NVMIASTAMFIVSLLL---IPHPVCSLwvtFAIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDFSAHISYAFVS- 467
Cdd:COG1033  610 SLLLALLLIFLLLLLAfrsLRLGLISL---IPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREe 686

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149055143 468 -SNEPSVNKKSIEALYLLGYPVLQSAISTIIGVCVLAAAKAYIFRTFFKIMFLVMFFGAAHGLIFIPVFLTFF 539
Cdd:COG1033  687 rRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLL 759
 
Name Accession Description Interval E-value
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 2-539 1.71e-127

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 391.33  E-value: 1.71e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143    2 WVAVFGVFSVAMSVVSGFGLMLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWQKTSLTESVSERLSNSYSKVAVSITI 81
Cdd:pfam02460 250 ILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSITI 329

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   82 TTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALDGKREV----VWSRWLEKPDQKYSSFkkfccv 157
Cdd:pfam02460 330 TSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAegrhCLFVWATSSPQRIDSE------ 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  158 pfGSFPDEHGDDNHPMNLFFRDYFGPFLTTSKAKFIVVLIYIFYIISSIYGCFQVQEGLDLRNLASDDSYITPYFNVEED 237
Cdd:pfam02460 404 --GSEPDKSHNIEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREK 481

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  238 YFSDYGPRVMVIVTETVNYWDKDVRQKLDKCMTQFEQNEY-VDKNLTEFWLEAYMQY---MNNTGNNPNDKNTFMNNIAG 313
Cdd:pfam02460 482 HFWPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYsLGPNSTLFWLREYENFlstLNMEEEEDEEKEWSYGNLPS 561

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  314 FLN--FFPVFTYDINVSSSN-EITSSRGFIQTIDVSSSSNKKRMLLKLRGIA-ENCEVPLMVYNQAFIYFDQYAAIIENT 389
Cdd:pfam02460 562 FLKapGNSHWAGDLVWDDNTtMVTKFRFTLAGKGLSTWNDRTRALQEWRSIAdQYPEFNVTVFDEDAPFADQYLTILPST 641

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  390 VRNVMIASTAMFIVSLLLIPHPVCSLWVTFAIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDFSAHISYAFVSSN 469
Cdd:pfam02460 642 IQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSR 721

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  470 EPSVNKKSIEALYLLGYPVLQSAISTIIGVCVLAAAKAYIFRTFFKIMFLVMFFGAAHGLIFIPVFLTFF 539
Cdd:pfam02460 722 GDTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIILSLF 791
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 7-539 1.38e-52

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 193.20  E-value: 1.38e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143     7 GVFSVAMSVVSGFGLMLHIGVPFVIIVANS-PFLILGVGVDDMFIMISAWQ-----------KTSLTESVSERLSNSYSK 74
Cdd:TIGR00917  613 GILIVMLSVLGSVGVFSAVGLKSTLIIMEViPFLVLAVGVDNIFILVFFYFyleyfyrqvgvDNEQELTLERRLSRALME 692

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143    75 VAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALDGKRevvwsrwlekpdQKYSSFKKF 154
Cdd:TIGR00917  693 VGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKR------------TEDKRVDCF 760

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   155 CCVPF--GSFPDEHGDDNHPMNL---FFRDYFGPFLTTSKAKFIVVLIYIFYIISSIYGCFQVQEGLDLRNLASDDSYIT 229
Cdd:TIGR00917  761 PCIKTskSSISAEKGSGQRKAGLltrYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQ 840

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   230 PYFNVEEDYFsDYGPRVMVIVTETVNYWDKDVRQKL--------DKCMTQFEQNEYVDKNLTEfWLEAYMQYM------- 294
Cdd:TIGR00917  841 IYFASLTPLL-EVGPPFYIVIKGDYNYTDFESQNKLctmggcdkDSIVNVFNNLSYIAKPASS-WLDDYLVWLspqascc 918

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   295 ---NNTG---NNPNDK----NTFMNNIAG------FLNFFPVFTYDIN-----------VSSSNEITSSRGFIQ------ 341
Cdd:TIGR00917  919 crkFTNGtfcNGPDPQcfrcADLSSDAQGrpsttqFKEKLPWFLNALPsadcakgghaaYSSAVDLQGYATIIQassfrt 998

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   342 -------TIDVSSSSNKKRMLLKlrGIAENCEVPLMVYNQAFIYFDQYAAIIENTVRNVMIASTAMFIVSLLLIPhpvCS 414
Cdd:TIGR00917  999 yhtplntQVDFINAMRAAQEFAA--KVSRSSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQ---LN 1073

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   415 LWVTF----AIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDFSAHISYAFVSSNEPSVNKKSIEALYLLGYPVLQ 490
Cdd:TIGR00917 1074 ALSVVnlimSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFS 1153

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|.
gi 149055143   491 S-AISTIIGVCVLAAAKAYIFRTFFKIMFLVM-FFGAAHGLIFIPVFLTFF 539
Cdd:TIGR00917 1154 GiTLTKLVGVVVLGFSRSEIFVVYYFRMYLALvLLGFLHGLVFLPVLLSVL 1204
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 2-134 1.05e-34

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 127.70  E-value: 1.05e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143    2 WVAVFGVFSVAMSVVSGFGLMLHIGVPFVIIVANS-PFLILGVGVDDMFIMISAWQKTSLTESVSERLSNSYSKVAVSIT 80
Cdd:pfam12349   7 GLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEViPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGEVGPSIT 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 149055143   81 ITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALDGKRE 134
Cdd:pfam12349  87 LTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRL 140
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
3-539 6.60e-32

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 131.16  E-value: 6.60e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143     3 VAVFGVFSVAMSVVSGFGLMLHIGVPFVIIVANS-PFLILGVGVDDMFIMISAWQKTSLTESVSERLSNSYSKVAVSITI 81
Cdd:TIGR00918  429 VGLAGVLLVALSVAAGLGLCALLGISFNAATTQVlPFLALGVGVDDVFLLAHAFSETGQNIPFEERTGECLKRTGASVVL 508

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143    82 TTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALDGKRevvwsrwleKPDQKYSSFkkFCCVPFGS 161
Cdd:TIGR00918  509 TSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRR---------REDRRLDIF--CCFFSPCS 577

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   162 F------PDEHGDDNHP--------------------------------------------------------------- 172
Cdd:TIGR00918  578 ArviqiePQAYADGSAPpvysshmqstvqlrteydpgtqhyyttneprshlsvqpsdplscqspdiagstrdllsqfeds 657

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   173 -------------MNLFFRDYFGPFLTTSKAKFIVVLIYIFYIISSIYGCFQVQEGLDLRNLASDDSYITPYFNVEEDYF 239
Cdd:TIGR00918  658 kaaclslpcarwtLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDAQFRYF 737

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   240 SDYGprvMVIVTE-TVNYwdKDVRQKLDKCMTQFEQNEYVDKN----LTEFWLEAYMQYMNN------------------ 296
Cdd:TIGR00918  738 SFYN---MYAVTQgNFDY--PTQQQLLYDLHQSFSSVKYVLKEdngqLPRMWLHYFRDWLQGlqkafdedwrdgritken 812

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   297 -----------------TGN--NPNDKNTFMN----NIAGFLNFFPVFTYdINVSSSNEI---TSSRG---------FIQ 341
Cdd:TIGR00918  813 yrngsddavlaykllvqTGHrdKPVDKEQLTTqrlvNADGIINPNAFYIY-LSAWVSNDPvayAASQAniyphppewLHD 891

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   342 TIDVSSSSNK---------KRMLLKLRGIAENCEVPLMV---------YNQA----------FIYFDQYAAIIENTVRNV 393
Cdd:TIGR00918  892 KNDYDPENLRipaaepleyAQFPFYLNGLRETSQFVEAIehvraicnnYEGFglpsypsgypFLFWEQYMGLRHWLLLSI 971

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   394 MIASTAMFIVSLLLIPHPVCSLWVTFAIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDFSAHISYAFVSSnEPSV 473
Cdd:TIGR00918  972 SVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGFLTA-IGDR 1050

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149055143   474 NKKSIEALYLLGYPVLQSAISTIIGVCVLAAAK-AYIFRTFFKIMFLVMFFGAAHGLIFIPVFLTFF 539
Cdd:TIGR00918 1051 NRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEfDFIVRYFFAVLAVLTCLGVLNGLVLLPVLLSMF 1117
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
2-539 6.37e-20

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 93.77  E-value: 6.37e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143   2 WVAVFGVFSVAMSVVSGFGLMLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWQK-TSLTESVSERLSNSYSKVAVSIT 80
Cdd:COG1033  243 RGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREeRRKGLDKREALREALRKLGPPVL 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  81 ITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALdgkrevvwsrwLEKPDQKYSSFKKfccvpfg 160
Cdd:COG1033  323 LTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSL-----------LPRPKPKTRRLKK------- 384

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143 161 sfpdeHGDDNHPMNLFFRdyfgpflTTSKAKFIVVLIYIFYIISSIYGCFQVQ-EGLDLRNLASDDSYITPYFNVEEDYF 239
Cdd:COG1033  385 -----PPELGRLLAKLAR-------FVLRRPKVILVVALVLAVVSLYGISRLKvEYDFEDYLPEDSPIRQDLDFIEENFG 452

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143 240 SDYGPRVMVIVTETVNYWDKDVRQKLDKCMTQFEQNEYVDKNLTefwLEAYMQYMNNTGNNPNDKNTFMNNIAGFLNFFP 319
Cdd:COG1033  453 GSDPLEVVVDTGEPDGLKDPEVLKEIDRLQDYLESLPEVGKVLS---LADLVKELNQALNEGDPKYYALPESRELLAQLL 529

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143 320 VFTYDINVSSSNEITS---SRGFIQ-TIDVSSSSNKKRMLLKLR-GIAENCEVPLMVYN---QAFIYFDQYAAIIENTVR 391
Cdd:COG1033  530 LLLSSPPGDDLSRFVDedySAARVTvRLKDLDSEEIKALVEEVRaFLAENFPPDGVEVTltgSAVLFAAINESVIESQIR 609

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143 392 NVMIASTAMFIVSLLL---IPHPVCSLwvtFAIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDFSAHISYAFVS- 467
Cdd:COG1033  610 SLLLALLLIFLLLLLAfrsLRLGLISL---IPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREe 686

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149055143 468 -SNEPSVNKKSIEALYLLGYPVLQSAISTIIGVCVLAAAKAYIFRTFFKIMFLVMFFGAAHGLIFIPVFLTFF 539
Cdd:COG1033  687 rRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLL 759
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 208-539 6.61e-06

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 49.07  E-value: 6.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  208 GCFQVQEGLDLRNLASDDSYITP-YFNVEEDYFSdyGPRVMVIVTETVNYWDKDVRQKLDKCMTQFEQNEYVDKNlteFW 286
Cdd:TIGR00921  21 GAQHLNVESDTEKQLPKDFESYKwYHVLQREFGT--STKTLLVVIEGDDVTRKPVLDYMRRLEQRLREKPYVTNV---RS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  287 LEAYMQYMNNTGNNPNDkntfMNNIAGFLNFFPVFtYDINVSSSNEITssrgfIQTIDVSSSSNKKrmllKLRGIAENCE 366
Cdd:TIGR00921  96 AADIMRQIPGNFPLPVT----MPEVRPLMSEYPRS-KEMFLSKDHTVA-----IIIVQLKSDADYK----QVVPIYNDVE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  367 -----------VPLMVYNQAFIYFDQYAAIIENTVRNVMIASTAMFIVSLLLIPHPVCSLWVTFAIASVIVGVTGFMAFW 435
Cdd:TIGR00921 162 rslertnppsgKFLDVTGSPAINYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143  436 NVNLDSISMINLVICIGFSFDFSAHISYAFvsSNEPSVNKKSIEALYL----LGYPVLQSAISTIIGVCVLAAAKAYIFR 511
Cdd:TIGR00921 242 GIPLYATTLLAVPMLIGVGIDYGIQTLNRY--EEERDIGRAKGEAIVTavrrTGRAVLIALLTTSAGFAALALSEFPMVS 319

                         330       340
                  ....*....|....*....|....*...
gi 149055143  512 TFFKIMFLVMFFGAAHGLIFIPVFLTFF 539
Cdd:TIGR00921 320 EFGLGLVAGLITAYLLTLLVLPALLQSI 347
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 2-121 2.43e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 47.14  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143    2 WVAVFGVFSVAMSVVSGFGLMLHIGVPFVIIVANSPFLILGVGVD-DMFIMISAWQKTSLTESVSERLSNSYSKVAVSIT 80
Cdd:TIGR00921 218 WRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDyGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVL 297

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 149055143   81 ITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSIT 121
Cdd:TIGR00921 298 IALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLL 338
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
221-539 4.12e-05

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 46.39  E-value: 4.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143 221 LASDDSYITPYFNVEEDYFSDygPRVMVIVTETVNYWDKDVRQKLDKCMTQFEQNEYVDK----------NLTEFWLEAY 290
Cdd:COG1033   46 LPEDDPSVQAYDEFEEEFGGD--DTVVVAVEGKDDIFTPETLEALRELTEELEEIPGVDSvtsltnvratEGTEDGLTVE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143 291 MQYMNNTGNNPNDKNTFMNNIAGFLNFfpvftYDINVSSSNEITSSRGFIQTIDVSSSSNKKRMLLKLRGIAENCE---V 367
Cdd:COG1033  124 PLIPDELPASPEELAELREKVLSSPLY-----VGRLVSPDGKATLIVVTLDPDPLSSDLDRKEVVAEIRAIIAKYEdpgV 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143 368 PLMVYNQAFIYFDQYAAIIENTVRNVMIASTAMFIVSLLLIPHPVcslWVTFAIASVIVGVT---GFMAFWNVNLDSISM 444
Cdd:COG1033  199 EVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLR---GVLLPLLVVLLAVIwtlGLMGLLGIPLSPLTI 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143 445 INLVICIGFSFDFSAHI--SYAFVSSNEPSVNKKSIEALYLLGYPVLQSAISTIIGVCVLAAAKAYIFRTFFKIMFLVMF 522
Cdd:COG1033  276 LVPPLLLAIGIDYGIHLlnRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVL 355

                        330
                 ....*....|....*..
gi 149055143 523 FGAAHGLIFIPVFLTFF 539
Cdd:COG1033  356 LAFLTSLTLLPALLSLL 372
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 3-129 5.55e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 45.98  E-value: 5.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143    3 VAVFGVfsVAMSVVSGF--GLMLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWQKTSLTESVSERLSNSYSKVAVSIT 80
Cdd:TIGR00921 593 KAVFPL--IAIGSGILWaiGLMGLRGIPSFLAMATTISIILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGIL 670

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 149055143   81 ITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMAL 129
Cdd:TIGR00921 671 FSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 1-141 2.06e-03

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 41.14  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149055143    1 MWVAVFG---VFSVAMSVVSG------FGLMLhIGVPFVIIVANSPFLIlGVGVDdmF-IMISAWQKTSLTESVSER--L 68
Cdd:TIGR03480 286 LWLALRSprlVFAVLVTLIVGliltaaFATLA-VGHLNLISVAFAVLFI-GLGVD--FaIQFSLRYREERFRGGNHReaL 361

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149055143   69 SNSYSKVAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMAL---DGKREVVWSRWL 141
Cdd:TIGR03480 362 SVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPALLRLlrpPRRRKPPGYATL 437
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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