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Conserved domains on  [gi|119592889|gb|EAW72483|]
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zinc finger protein 264, isoform CRA_a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-74 1.10e-31

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.92  E-value: 1.10e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119592889    14 VTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSLGCPVPKAELICHLEHGQEPWT 74
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
257-561 7.17e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 7.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 257 RPYECMECGKAFNRKSYLTQHQRIHSGEKPYKCN--ECGKAFTHRSNFVLHNRRHTGEKSFVCTecgQVFRHRPGFLRHY 334
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 335 VVHSG--ENPYECLECGKVFKHRSYlmwHQQTHTGEKPYE--------CSECGKVFLESAALIH-HYVIHTGEKPFECLE 403
Cdd:COG5048  109 SLSSSssNSNDNNLLSSHSLPPSSR---DPQLPDLLSISNlrnnplpgNNSSSVNTPQSNSLHPpLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 404 CGKAFNHRSYLKRHQ----RIHTGEKPFVCSECGK------AFTHCSTFILHKR--------AHTGEKPFECKECG---- 461
Cdd:COG5048  186 LLISSNVSTSIPSSSenspLSSSYSIPSSSSDQNLenssssLPLTTNSQLSPKSllsqspssLSSSDSSSSASESPrssl 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 462 --KAFSNRKDLIRHFSIHTG-EKPYECVECGKAFTRMSGLTRHKR--IHSGE--KPYECVE--CGKSFCWSTNLIRHAII 532
Cdd:COG5048  266 ptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350
                 ....*....|....*....|....*....|.
gi 119592889 533 HTGEKPYKC--SECGKAFSRSSSLTQHQRMH 561
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
104-333 1.75e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 104 SEGISLQGQVTQGNSVDSQLGQAEDQDGLSEMQEGHFRPGIDPQEKSPgkmSPECDGLGTADGVCSRIGQEQVSPGDTVH 183
Cdd:COG5048  226 SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS---SPNESDSSSEKGFSLPIKSKQCNISFSRS 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 184 SHNSCESGKDPMIQEEENNFKCSE--CGKVFNKKHLLAGHEKIHSGVKPYEC--TECGKTFIKSTH-----LLQHHMIHT 254
Cdd:COG5048  303 SPLTRHLRSVNHSGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLK 382

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 255 GERPYECM--ECGKAFNRKSYLTQH--QRIHSGEKPYKCNECGKAFTHRSNFVLHNRRHTgEKSFVCTECGQVFRHRPGF 330
Cdd:COG5048  383 NDKKSETLsnSCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDL 461


                 ...
gi 119592889 331 LRH 333
Cdd:COG5048  462 SNH 464
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-74 1.10e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.92  E-value: 1.10e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119592889    14 VTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSLGCPVPKAELICHLEHGQEPWT 74
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-54 3.17e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 3.17e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 119592889   13 SVTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSLG 54
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-53 1.37e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.37e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 119592889  14 VTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSL 53
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
257-561 7.17e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 7.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 257 RPYECMECGKAFNRKSYLTQHQRIHSGEKPYKCN--ECGKAFTHRSNFVLHNRRHTGEKSFVCTecgQVFRHRPGFLRHY 334
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 335 VVHSG--ENPYECLECGKVFKHRSYlmwHQQTHTGEKPYE--------CSECGKVFLESAALIH-HYVIHTGEKPFECLE 403
Cdd:COG5048  109 SLSSSssNSNDNNLLSSHSLPPSSR---DPQLPDLLSISNlrnnplpgNNSSSVNTPQSNSLHPpLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 404 CGKAFNHRSYLKRHQ----RIHTGEKPFVCSECGK------AFTHCSTFILHKR--------AHTGEKPFECKECG---- 461
Cdd:COG5048  186 LLISSNVSTSIPSSSenspLSSSYSIPSSSSDQNLenssssLPLTTNSQLSPKSllsqspssLSSSDSSSSASESPrssl 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 462 --KAFSNRKDLIRHFSIHTG-EKPYECVECGKAFTRMSGLTRHKR--IHSGE--KPYECVE--CGKSFCWSTNLIRHAII 532
Cdd:COG5048  266 ptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350
                 ....*....|....*....|....*....|.
gi 119592889 533 HTGEKPYKC--SECGKAFSRSSSLTQHQRMH 561
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
zf-H2C2_2 pfam13465
Zinc-finger double domain;
413-438 9.79e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 9.79e-06
                          10        20
                  ....*....|....*....|....*.
gi 119592889  413 YLKRHQRIHTGEKPFVCSECGKAFTH 438
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
104-333 1.75e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 104 SEGISLQGQVTQGNSVDSQLGQAEDQDGLSEMQEGHFRPGIDPQEKSPgkmSPECDGLGTADGVCSRIGQEQVSPGDTVH 183
Cdd:COG5048  226 SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS---SPNESDSSSEKGFSLPIKSKQCNISFSRS 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 184 SHNSCESGKDPMIQEEENNFKCSE--CGKVFNKKHLLAGHEKIHSGVKPYEC--TECGKTFIKSTH-----LLQHHMIHT 254
Cdd:COG5048  303 SPLTRHLRSVNHSGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLK 382

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 255 GERPYECM--ECGKAFNRKSYLTQH--QRIHSGEKPYKCNECGKAFTHRSNFVLHNRRHTgEKSFVCTECGQVFRHRPGF 330
Cdd:COG5048  383 NDKKSETLsnSCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDL 461


                 ...
gi 119592889 331 LRH 333
Cdd:COG5048  462 SNH 464
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-74 1.10e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.92  E-value: 1.10e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119592889    14 VTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSLGCPVPKAELICHLEHGQEPWT 74
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-54 3.17e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 3.17e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 119592889   13 SVTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSLG 54
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-53 1.37e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.37e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 119592889  14 VTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSL 53
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
257-561 7.17e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 7.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 257 RPYECMECGKAFNRKSYLTQHQRIHSGEKPYKCN--ECGKAFTHRSNFVLHNRRHTGEKSFVCTecgQVFRHRPGFLRHY 334
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 335 VVHSG--ENPYECLECGKVFKHRSYlmwHQQTHTGEKPYE--------CSECGKVFLESAALIH-HYVIHTGEKPFECLE 403
Cdd:COG5048  109 SLSSSssNSNDNNLLSSHSLPPSSR---DPQLPDLLSISNlrnnplpgNNSSSVNTPQSNSLHPpLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 404 CGKAFNHRSYLKRHQ----RIHTGEKPFVCSECGK------AFTHCSTFILHKR--------AHTGEKPFECKECG---- 461
Cdd:COG5048  186 LLISSNVSTSIPSSSenspLSSSYSIPSSSSDQNLenssssLPLTTNSQLSPKSllsqspssLSSSDSSSSASESPrssl 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 462 --KAFSNRKDLIRHFSIHTG-EKPYECVECGKAFTRMSGLTRHKR--IHSGE--KPYECVE--CGKSFCWSTNLIRHAII 532
Cdd:COG5048  266 ptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350
                 ....*....|....*....|....*....|.
gi 119592889 533 HTGEKPYKC--SECGKAFSRSSSLTQHQRMH 561
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
184-568 7.77e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 7.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 184 SHNSCESGKDPMIQEEENN--FKCSECGKVFNKKHLLAGHEKIHSGVKPYECT--ECGKTFIKSTHLLQHHMIHTGERPY 259
Cdd:COG5048   13 NSVLSSTPKSTLKSLSNAPrpDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSD 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 260 ECmeCGKAFNRKSYLTQHQRIHSGE---KPYKCNECGKAFTHR--------SNFVLHNRRHTGEKSFVCT---------- 318
Cdd:COG5048   93 LN--SKSLPLSNSKASSSSLSSSSSnsnDNNLLSSHSLPPSSRdpqlpdllSISNLRNNPLPGNNSSSVNtpqsnslhpp 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 319 -----ECGQVFRHRPGFLRHYVVHSGENPYECLECgkvfkHRSYLMWHQQTH----TGEKPYECSECGKVFLESaaLIHH 389
Cdd:COG5048  171 lpansLSKDPSSNLSLLISSNVSTSIPSSSENSPL-----SSSYSIPSSSSDqnleNSSSSLPLTTNSQLSPKS--LLSQ 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 390 YVIHTGeKPFECLECGKAFNHRSYLKRHQRIH----------TGEKPFVCSECGKAFTHCSTFILHKRA--HTGE--KPF 455
Cdd:COG5048  244 SPSSLS-SSDSSSSASESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPF 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 456 ECKE--CGKAFSNRKDLIRHFSIHTGEKPYECV--ECGKAFTRMS-----GLTRHKRIHSGEKPYECVE-CGKSFCWST- 524
Cdd:COG5048  323 SCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLSnSCIRNFKRDs 402

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 119592889 525 NLIRHAIIHTGEKPY--KCSECGKAFSRSSSLTQHQRMHTGKNPIS 568
Cdd:COG5048  403 NLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
229-434 1.08e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 229 KPYECTECGKTFIKSTHLLQH--HMIHTGE--RPYECME--CGKAFNRKSYLTQHQRIHSGEKPYKC--NECGKAFTHRS 300
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 301 NfvlhnrrhtgeksfvctecgqvfRHRPGFLRHYVVHSGENPYECL--ECGKVFKHRSYLMWHQQTHTGEKPYECSecgk 378
Cdd:COG5048  368 N-----------------------NEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCK---- 420

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 119592889 379 vflesaalihhyvihtgekpfeCLECGKAFNHRSYLKRHQRIHTGEKPFVCSECGK 434
Cdd:COG5048  421 ----------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
285-580 1.54e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 285 KPYKCNECGKAFTHRSNFVLHNRRHTGEKSFVCTECGQVF-RHRPGFLRHYVVHSGENPYECLEcgkvfkHRSYLMWHQQ 363
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKsFSRPLELSRHLRTHHNNPSDLNS------KSLPLSNSKA 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 364 THTgEKPYECSECGKVFLESAALIHHYVIHTgEKPFECLEC--GKAFNHRSYLKRHQRIHTGEKPFVCS--ECGKAFTHC 439
Cdd:COG5048  106 SSS-SLSSSSSNSNDNNLLSSHSLPPSSRDP-QLPDLLSISnlRNNPLPGNNSSSVNTPQSNSLHPPLPanSLSKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 440 STFILHKRAHTGEKPFECKECGKAFSNRKDLIRHFSIHTGEKPYECVECGKAF--------------------------- 492
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqspsslsssdssssasesprs 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 493 ---TRMSGLTRHKRIHSGE-----KPYECVECGKSFCWSTNLIRH--AIIHTGE--KPYKCSE--CGKAFSRSSSLTQHQ 558
Cdd:COG5048  264 slpTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        330       340
                 ....*....|....*....|..
gi 119592889 559 RMHTGKNPISVTDVGRPFTSGQ 580
Cdd:COG5048  344 LLHTSISPAKEKLLNSSSKFSP 365
zf-H2C2_2 pfam13465
Zinc-finger double domain;
413-438 9.79e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 9.79e-06
                          10        20
                  ....*....|....*....|....*.
gi 119592889  413 YLKRHQRIHTGEKPFVCSECGKAFTH 438
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
273-298 5.60e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.60e-05
                          10        20
                  ....*....|....*....|....*.
gi 119592889  273 YLTQHQRIHSGEKPYKCNECGKAFTH 298
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
525-550 9.42e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 9.42e-05
                          10        20
                  ....*....|....*....|....*.
gi 119592889  525 NLIRHAIIHTGEKPYKCSECGKAFSR 550
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
276-503 1.82e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 276 QHQRIHSGEKPYKCNECGKAFTHRSNFVLHNRRHTGEKSFVCTECGQVFRHRPGFLRHYVVHSGE-------NPYECLEC 348
Cdd:COG5048  216 SDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQC 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 349 GKVFKHRSYLMWHQQT--HTGE--KPYECSE--CGKVFLESAALIHHYVIHTGEKPFEC--LECGKAFNHRSYLKRHQRI 420
Cdd:COG5048  296 NISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSL 375

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 421 H-----TGEKPFVC--SECGKAFTHCSTFILHKRAHTGEKP--FECKECGKAFSNRKDLIRHFSIHTGEKPYECvECGKA 491
Cdd:COG5048  376 QqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKS 454

                        250
                 ....*....|..
gi 119592889 492 FTRMSGLTRHKR 503
Cdd:COG5048  455 FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
357-380 3.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.12e-04
                          10        20
                  ....*....|....*....|....
gi 119592889  357 YLMWHQQTHTGEKPYECSECGKVF 380
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 539-561 3.46e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 3.46e-04
                          10        20
                  ....*....|....*....|...
gi 119592889  539 YKCSECGKAFSRSSSLTQHQRMH 561
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-270 6.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.44e-04
                          10        20
                  ....*....|....*....|....*.
gi 119592889  245 HLLQHHMIHTGERPYECMECGKAFNR 270
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
498-520 1.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.36e-03
                          10        20
                  ....*....|....*....|...
gi 119592889  498 LTRHKRIHSGEKPYECVECGKSF 520
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 479-562 1.52e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 479 GEKPYEC--VECGKAFTRMSGLTRHkRIHSgekpyecvECGKSFCWSTNLIRHAIIHTGEKPYKCSECGKAFSRSSSLTQ 556
Cdd:COG5189  346 DGKPYKCpvEGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 119592889 557 HqRMHT 562
Cdd:COG5189  417 H-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
104-333 1.75e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 104 SEGISLQGQVTQGNSVDSQLGQAEDQDGLSEMQEGHFRPGIDPQEKSPgkmSPECDGLGTADGVCSRIGQEQVSPGDTVH 183
Cdd:COG5048  226 SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS---SPNESDSSSEKGFSLPIKSKQCNISFSRS 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 184 SHNSCESGKDPMIQEEENNFKCSE--CGKVFNKKHLLAGHEKIHSGVKPYEC--TECGKTFIKSTH-----LLQHHMIHT 254
Cdd:COG5048  303 SPLTRHLRSVNHSGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLK 382

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592889 255 GERPYECM--ECGKAFNRKSYLTQH--QRIHSGEKPYKCNECGKAFTHRSNFVLHNRRHTgEKSFVCTECGQVFRHRPGF 330
Cdd:COG5048  383 NDKKSETLsnSCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDL 461


                 ...
gi 119592889 331 LRH 333
Cdd:COG5048  462 SNH 464
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 399-421 1.97e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.97e-03
                          10        20
                  ....*....|....*....|...
gi 119592889  399 FECLECGKAFNHRSYLKRHQRIH 421
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 259-281 3.09e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.09e-03
                          10        20
                  ....*....|....*....|...
gi 119592889  259 YECMECGKAFNRKSYLTQHQRIH 281
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
445-466 4.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.50e-03
                          10        20
                  ....*....|....*....|..
gi 119592889  445 HKRAHTGEKPFECKECGKAFSN 466
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
469-494 4.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.55e-03
                          10        20
                  ....*....|....*....|....*.
gi 119592889  469 DLIRHFSIHTGEKPYECVECGKAFTR 494
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 343-365 4.57e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.57e-03
                          10        20
                  ....*....|....*....|...
gi 119592889  343 YECLECGKVFKHRSYLMWHQQTH 365
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 287-309 9.73e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.73e-03
                          10        20
                  ....*....|....*....|...
gi 119592889  287 YKCNECGKAFTHRSNFVLHNRRH 309
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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