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Conserved domains on  [gi|119586491|gb|EAW66087|]
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importin 4, isoform CRA_h [Homo sapiens]

Protein Classification

importin beta family protein( domain architecture ID 707677)

importin beta family protein may function in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
342-605 2.04e-08

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 58.41  E-value: 2.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586491  342 LEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQFSENLqPHISSYSREV 421
Cdd:COG5215   371 VEQNIRSESWANREAAVMAFGSVMHGPCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHV-AMIISPCGHL 449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586491  422 MPLLLAYLKSVpLGHTHHLAKACYALENFVENLGPKVQ-------PYLPELMECML---QLLRNPSSPRAKelAVSALGA 491
Cdd:COG5215   450 VLEVSASLIGL-MDCPFRSINCSWRKENLVDHIAKAVRevesflaKFYLAILNALVkgtELALNESNLRVS--LFSALGT 526

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586491  492 IATAAQASLLP----YFPAIMEHLRE--------FLLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLC 559
Cdd:COG5215   527 LILICPDAVSDilagFYDYTSKKLDEcisvlgqiLATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDQLMELFIRIL 606

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 119586491  560 DQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTE 605
Cdd:COG5215   607 ESTKPTTAFGDVYTAISALSTSLEERFEQYASKFIPYLTRALNCTD 652
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
342-605 2.04e-08

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 58.41  E-value: 2.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586491  342 LEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQFSENLqPHISSYSREV 421
Cdd:COG5215   371 VEQNIRSESWANREAAVMAFGSVMHGPCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHV-AMIISPCGHL 449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586491  422 MPLLLAYLKSVpLGHTHHLAKACYALENFVENLGPKVQ-------PYLPELMECML---QLLRNPSSPRAKelAVSALGA 491
Cdd:COG5215   450 VLEVSASLIGL-MDCPFRSINCSWRKENLVDHIAKAVRevesflaKFYLAILNALVkgtELALNESNLRVS--LFSALGT 526

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586491  492 IATAAQASLLP----YFPAIMEHLRE--------FLLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLC 559
Cdd:COG5215   527 LILICPDAVSDilagFYDYTSKKLDEcisvlgqiLATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDQLMELFIRIL 606

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 119586491  560 DQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTE 605
Cdd:COG5215   607 ESTKPTTAFGDVYTAISALSTSLEERFEQYASKFIPYLTRALNCTD 652
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 351-406 8.62e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.50  E-value: 8.62e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 119586491   351 PYQRKAGLLVLAVLSDGAGDHIRQrLLPPLLQIVCKGLEDPSQVVRNAALFALGQF 406
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAP-AVPELLPALLPLLNDDSDLVREAAAWALGRL 55
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
342-605 2.04e-08

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 58.41  E-value: 2.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586491  342 LEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQFSENLqPHISSYSREV 421
Cdd:COG5215   371 VEQNIRSESWANREAAVMAFGSVMHGPCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHV-AMIISPCGHL 449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586491  422 MPLLLAYLKSVpLGHTHHLAKACYALENFVENLGPKVQ-------PYLPELMECML---QLLRNPSSPRAKelAVSALGA 491
Cdd:COG5215   450 VLEVSASLIGL-MDCPFRSINCSWRKENLVDHIAKAVRevesflaKFYLAILNALVkgtELALNESNLRVS--LFSALGT 526

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586491  492 IATAAQASLLP----YFPAIMEHLRE--------FLLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLC 559
Cdd:COG5215   527 LILICPDAVSDilagFYDYTSKKLDEcisvlgqiLATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDQLMELFIRIL 606

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 119586491  560 DQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTE 605
Cdd:COG5215   607 ESTKPTTAFGDVYTAISALSTSLEERFEQYASKFIPYLTRALNCTD 652
HSH155 COG5181
U2 snRNP spliceosome subunit [RNA processing and modification];
336-486 6.34e-05

U2 snRNP spliceosome subunit [RNA processing and modification];


Pssm-ID: 227508 [Multi-domain]  Cd Length: 975  Bit Score: 47.25  E-value: 6.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586491  336 PQLMPMLEEALRSESPYQ-RKAGLLVLAVLSDGAGdhiRQRL--LPPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQP 412
Cdd:COG5181   315 EELLPFLEALCGSRKSWEaRHTGIRIAQQICELLG---RSRLshLGPLLKCISKLLKDRSRFVRIDTANALSYLAELVGP 391

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119586491  413 hissYSREVMPLLLAYLKSvplGHTHHLAKACYALENFVENLGPKVQP-----YLPELMECMLQLLRNPSSPRAKELAV 486
Cdd:COG5181   392 ----YGIEQFDEVLCPLWE---GASQHRGKELVSFLKAMGFIIPLMSPeyachDTREHMEIVFREFKSPDEEMKKDLLV 463
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 351-406 8.62e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.50  E-value: 8.62e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 119586491   351 PYQRKAGLLVLAVLSDGAGDHIRQrLLPPLLQIVCKGLEDPSQVVRNAALFALGQF 406
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAP-AVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
336-493 1.97e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 39.61  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586491  336 PQLMPMLEEALRSESPYQRKAGLLVLAVLSDgagdhirQRLLPPLLQIvckgLEDPSQVVRNAALFALGQFsenlqphis 415
Cdd:COG1413    15 PAAVPALIAALADEDPDVRAAAARALGRLGD-------PRAVPALLEA----LKDPDPEVRAAAAEALGRI--------- 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119586491  416 sYSREVMPLLLAYLKSVPLGHTHHLAKACYALENfvenlgpkvqpylPELMECMLQLLRNPsSPRAKELAVSALGAIA 493
Cdd:COG1413    75 -GDPEAVPALIAALKDEDPEVRRAAAEALGRLGD-------------PAAVPALLEALKDP-DWEVRRAAARALGRLG 137
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 380-410 3.99e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 35.97  E-value: 3.99e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 119586491   380 LLQIVCKGLEDPSQVVRNAALFALGQFSENL 410
Cdd:pfam02985    1 LLPLLLKLLNDPSPEVREAAAEALGELAEVL 31
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 320-490 7.65e-03

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 40.30  E-value: 7.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586491   320 QVVDMLALH----LPPEKLCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDhirqrLLPPLLQIVCKGLEDPSQVV 395
Cdd:pfam01602   93 QLIRGLALRtlscIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPD-----LVRDFVPELKELLSDKDPGV 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586491   396 RNAALFALGQFSEN-------LQPHISSYSR---EVMPLLLAYLKSV--PLGHTHHLAKacyalENFVENLGPKVQPYLP 463
Cdd:pfam01602  168 QSAAVALLYEICKNdrlylklLPLLFRRLCNllgVLNPWLQVKILRLltRLAPLDPLLP-----KELLEDLLNLLQNSNN 242

                          170       180
                   ....*....|....*....|....*...
gi 119586491   464 E-LMECMLQLLRNPSSPRAKELAVSALG 490
Cdd:pfam01602  243 AvLYETANTIVHLAPAPELIVLAVNALG 270
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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