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Conserved domains on  [gi|119586484|gb|EAW66080|]
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importin 4, isoform CRA_c [Homo sapiens]

Protein Classification

importin beta family protein( domain architecture ID 707677)

importin beta family protein may function in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
221-484 6.87e-09

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 59.57  E-value: 6.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586484 221 LEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQFSENLqPHISSYSREV 300
Cdd:COG5215  371 VEQNIRSESWANREAAVMAFGSVMHGPCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHV-AMIISPCGHL 449

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586484 301 MPLLLAYLKSVpLGHTHHLAKACYALENFVENLGPKVQ-------PYLPELMECML---QLLRNPSSPRAKelAVSALGA 370
Cdd:COG5215  450 VLEVSASLIGL-MDCPFRSINCSWRKENLVDHIAKAVRevesflaKFYLAILNALVkgtELALNESNLRVS--LFSALGT 526

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586484 371 IATAAQASLLP----YFPAIMEHLRE--------FLLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLC 438
Cdd:COG5215  527 LILICPDAVSDilagFYDYTSKKLDEcisvlgqiLATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDQLMELFIRIL 606

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 119586484 439 DQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTE 484
Cdd:COG5215  607 ESTKPTTAFGDVYTAISALSTSLEERFEQYASKFIPYLTRALNCTD 652
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
221-484 6.87e-09

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 59.57  E-value: 6.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586484 221 LEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQFSENLqPHISSYSREV 300
Cdd:COG5215  371 VEQNIRSESWANREAAVMAFGSVMHGPCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHV-AMIISPCGHL 449

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586484 301 MPLLLAYLKSVpLGHTHHLAKACYALENFVENLGPKVQ-------PYLPELMECML---QLLRNPSSPRAKelAVSALGA 370
Cdd:COG5215  450 VLEVSASLIGL-MDCPFRSINCSWRKENLVDHIAKAVRevesflaKFYLAILNALVkgtELALNESNLRVS--LFSALGT 526

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586484 371 IATAAQASLLP----YFPAIMEHLRE--------FLLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLC 438
Cdd:COG5215  527 LILICPDAVSDilagFYDYTSKKLDEcisvlgqiLATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDQLMELFIRIL 606

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 119586484 439 DQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTE 484
Cdd:COG5215  607 ESTKPTTAFGDVYTAISALSTSLEERFEQYASKFIPYLTRALNCTD 652
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 230-285 5.49e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.50  E-value: 5.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 119586484  230 PYQRKAGLLVLAVLSDGAGDHIRQrLLPPLLQIVCKGLEDPSQVVRNAALFALGQF 285
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAP-AVPELLPALLPLLNDDSDLVREAAAWALGRL 55
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
221-484 6.87e-09

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 59.57  E-value: 6.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586484 221 LEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQFSENLqPHISSYSREV 300
Cdd:COG5215  371 VEQNIRSESWANREAAVMAFGSVMHGPCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHV-AMIISPCGHL 449

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586484 301 MPLLLAYLKSVpLGHTHHLAKACYALENFVENLGPKVQ-------PYLPELMECML---QLLRNPSSPRAKelAVSALGA 370
Cdd:COG5215  450 VLEVSASLIGL-MDCPFRSINCSWRKENLVDHIAKAVRevesflaKFYLAILNALVkgtELALNESNLRVS--LFSALGT 526

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586484 371 IATAAQASLLP----YFPAIMEHLRE--------FLLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLC 438
Cdd:COG5215  527 LILICPDAVSDilagFYDYTSKKLDEcisvlgqiLATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDQLMELFIRIL 606

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 119586484 439 DQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTE 484
Cdd:COG5215  607 ESTKPTTAFGDVYTAISALSTSLEERFEQYASKFIPYLTRALNCTD 652
HSH155 COG5181
U2 snRNP spliceosome subunit [RNA processing and modification];
215-365 3.38e-05

U2 snRNP spliceosome subunit [RNA processing and modification];


Pssm-ID: 227508 [Multi-domain]  Cd Length: 975  Bit Score: 47.64  E-value: 3.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586484 215 PQLMPMLEEALRSESPYQ-RKAGLLVLAVLSDGAGdhiRQRL--LPPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQP 291
Cdd:COG5181  315 EELLPFLEALCGSRKSWEaRHTGIRIAQQICELLG---RSRLshLGPLLKCISKLLKDRSRFVRIDTANALSYLAELVGP 391

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119586484 292 hissYSREVMPLLLAYLKSvplGHTHHLAKACYALENFVENLGPKVQP-----YLPELMECMLQLLRNPSSPRAKELAV 365
Cdd:COG5181  392 ----YGIEQFDEVLCPLWE---GASQHRGKELVSFLKAMGFIIPLMSPeyachDTREHMEIVFREFKSPDEEMKKDLLV 463
HEAT COG1413
HEAT repeat [General function prediction only];
215-372 2.01e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.92  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586484 215 PQLMPMLEEALRSESPYQRKAGLLVLAVLSDgagdhirQRLLPPLLQivckGLEDPSQVVRNAALFALGQFsenlqphis 294
Cdd:COG1413   15 PAAVPALIAALADEDPDVRAAAARALGRLGD-------PRAVPALLE----ALKDPDPEVRAAAAEALGRI--------- 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119586484 295 sYSREVMPLLLAYLKSVPLGHTHHLAKACYALENfvenlgpkvqpylPELMECMLQLLRNPsSPRAKELAVSALGAIA 372
Cdd:COG1413   75 -GDPEAVPALIAALKDEDPEVRRAAAEALGRLGD-------------PAAVPALLEALKDP-DWEVRRAAARALGRLG 137
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 230-285 5.49e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.50  E-value: 5.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 119586484  230 PYQRKAGLLVLAVLSDGAGDHIRQrLLPPLLQIVCKGLEDPSQVVRNAALFALGQF 285
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAP-AVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 256-369 3.24e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 37.32  E-value: 3.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586484  256 LPPLLQIVckgLEDPSQVVRNAALFALGQFSenlqphissySREVMPLLLAYLKSvplGHTHHLAKACYALENFvenlgp 335
Cdd:pfam13646   1 LPALLQAL---LRDPDPEVRAAAIRALGRIG----------DPEAVPALLELLKD---EDPAVRRAAAEALGKI------ 58

                          90       100       110
                  ....*....|....*....|....*....|....
gi 119586484  336 kvqpYLPELMECMLQLLRNPSSPRAKELAVSALG 369
Cdd:pfam13646  59 ----GDPEALPALLELLRDDDDDVVRAAAAEALA 88
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 259-289 3.30e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 35.58  E-value: 3.30e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 119586484  259 LLQIVCKGLEDPSQVVRNAALFALGQFSENL 289
Cdd:pfam02985   1 LLPLLLKLLNDPSPEVREAAAEALGELAEVL 31
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 199-369 3.41e-03

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 40.68  E-value: 3.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586484  199 QVVDMLALH----LPPEKLCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDhirqrLLPPLLQIVCKGLEDPSQVV 274
Cdd:pfam01602  93 QLIRGLALRtlscIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPD-----LVRDFVPELKELLSDKDPGV 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119586484  275 RNAALFALGQFSEN-------LQPHISSYSR---EVMPLLLAYLKSV--PLGHTHHLAKacyalENFVENLGPKVQPYLP 342
Cdd:pfam01602 168 QSAAVALLYEICKNdrlylklLPLLFRRLCNllgVLNPWLQVKILRLltRLAPLDPLLP-----KELLEDLLNLLQNSNN 242

                         170       180
                  ....*....|....*....|....*...
gi 119586484  343 E-LMECMLQLLRNPSSPRAKELAVSALG 369
Cdd:pfam01602 243 AvLYETANTIVHLAPAPELIVLAVNALG 270
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 322-371 6.71e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.42  E-value: 6.71e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 119586484  322 ACYALENFVENLGPKVQPYLPELMECMLQLLRNPsSPRAKELAVSALGAI 371
Cdd:pfam13513   7 AALALGSLAEGGPDLLAPAVPELLPALLPLLNDD-SDLVREAAAWALGRL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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