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Conserved domains on  [gi|28927093|gb|EAA36050|]
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ankyrin repeat and BTB/POZ domain-containing protein [Neurospora crassa OR74A]

Protein Classification

ankyrin repeat and BTB/POZ domain-containing protein( domain architecture ID 13788560)

ankyrin (ANK) repeat and BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein may be involved in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  17176038|17120193|15544948|8519696

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK_ABTB1_BPOZ cd18497
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 501-572 2.97e-29

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.


:

Pssm-ID: 350572  Cd Length: 72  Bit Score: 110.72  E-value: 2.97e-29
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28927093 501 VEPINVYDVIHAAWDLKVQRLEDFAARYLASRLEDYIDEEEFAELIQESASRLKRREETDTIELLDDIRYYL 572
Cdd:cd18497   1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 360-445 1.21e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18296:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 121  Bit Score: 87.74  E-value: 1.21e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 360 FPVHKAFLI-RSPYFETMFSSEFMEAKET-EHLHVIKV-DCLPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKL 436
Cdd:cd18296  29 FPCHKAFFCgRSDYFKALLRDHFAESEENnGSIPVVTLhDVSPEVFAIVLYYIYTDDTDLPPENAYDVLYVADMYLLPGL 108


                ....*....
gi 28927093 437 KTKAAVAIS 445
Cdd:cd18296 109 KRLCGTVLA 117
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 148-232 1.25e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 66.42  E-value: 1.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 148 TDISLLTASESFHLHKFILSSRSPYFRRKFADA---PETSTWKLSHsIPVEAFRVVIRYLYLGELPRDLvgprstATEEE 224
Cdd:cd18186   2 CDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGmkeSSSSEIELDD-VSPEAFEALLDYIYTGELELSE------ENVEE 74


                ....*...
gi 28927093 225 VFKGIDKL 232
Cdd:cd18186  75 LLAAADKL 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
3-97 8.77e-11

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.43  E-value: 8.77e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093   3 LRKDQLELKLKDDEQLIRQGVLRNEHPFDDSPEFHefiHACRRGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYE 82
Cdd:COG0666  58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLH---AAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLE 134

                        90
                ....*....|....*
gi 28927093  83 LVQLLLESGalADPD 97
Cdd:COG0666 135 IVKLLLEAG--ADVN 147
 
Name Accession Description Interval E-value
BACK_ABTB1_BPOZ cd18497
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 501-572 2.97e-29

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.


Pssm-ID: 350572  Cd Length: 72  Bit Score: 110.72  E-value: 2.97e-29
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28927093 501 VEPINVYDVIHAAWDLKVQRLEDFAARYLASRLEDYIDEEEFAELIQESASRLKRREETDTIELLDDIRYYL 572
Cdd:cd18497   1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 360-445 1.21e-20

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 87.74  E-value: 1.21e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 360 FPVHKAFLI-RSPYFETMFSSEFMEAKET-EHLHVIKV-DCLPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKL 436
Cdd:cd18296  29 FPCHKAFFCgRSDYFKALLRDHFAESEENnGSIPVVTLhDVSPEVFAIVLYYIYTDDTDLPPENAYDVLYVADMYLLPGL 108


                ....*....
gi 28927093 437 KTKAAVAIS 445
Cdd:cd18296 109 KRLCGTVLA 117
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 148-232 1.25e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 66.42  E-value: 1.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 148 TDISLLTASESFHLHKFILSSRSPYFRRKFADA---PETSTWKLSHsIPVEAFRVVIRYLYLGELPRDLvgprstATEEE 224
Cdd:cd18186   2 CDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGmkeSSSSEIELDD-VSPEAFEALLDYIYTGELELSE------ENVEE 74


                ....*...
gi 28927093 225 VFKGIDKL 232
Cdd:cd18186  75 LLAAADKL 82
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 360-439 2.00e-13

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 66.90  E-value: 2.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093   360 FPVHKAFL-IRSPYFETMFSSeFMEAKETEHLHVIKVDclPEVLEIILTFLYTERSdCPLELALDLLYAADMLLLDKLKT 438
Cdd:pfam00651  22 FRAHKAVLaACSPYFKALFSG-QESESSVSEITLDDVS--PEDFEALLEFMYTGKL-ISEENVDDLLAAADKLQIPSLVD 97


                  .
gi 28927093   439 K 439
Cdd:pfam00651  98 K 98
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 360-439 2.87e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 66.18  E-value: 2.87e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093    360 FPVHKAFLI-RSPYFETMFSSEFMEAKETEhlhVIKVDCLPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKLKT 438
Cdd:smart00225  11 FHAHKAVLAaHSPYFKALFSSDFKESDKSE---IYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVE 87


                   .
gi 28927093    439 K 439
Cdd:smart00225  88 L 88
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
3-97 8.77e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.43  E-value: 8.77e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093   3 LRKDQLELKLKDDEQLIRQGVLRNEHPFDDSPEFHefiHACRRGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYE 82
Cdd:COG0666  58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLH---AAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLE 134

                        90
                ....*....|....*
gi 28927093  83 LVQLLLESGalADPD 97
Cdd:COG0666 135 IVKLLLEAG--ADVN 147
Ank_2 pfam12796
Ankyrin repeats (3 copies);
39-89 5.87e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.58  E-value: 5.87e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 28927093    39 FIHACRRGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYELVQLLLE 89
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE 51
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 142-212 2.69e-08

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 52.26  E-value: 2.69e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28927093   142 REIPKTTDISLLTASESFHLHKFILSSRSPYFRRKFADAPETSTWK--LSHSIPVEAFRVVIRYLYLGELPRD 212
Cdd:pfam00651   5 REQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSeiTLDDVSPEDFEALLEFMYTGKLISE 77
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 149-209 4.37e-07

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 48.46  E-value: 4.37e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28927093    149 DISLLTASESFHLHKFILSSRSPYFRRKFADAP---ETSTWKLSHsIPVEAFRVVIRYLYLGEL 209
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkesDKSEIYLDD-VSPEDFRALLNFLYTGKL 63
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 38-102 3.77e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.73  E-value: 3.77e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28927093   38 EFIHACRRGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYELVQLLLESGalADPDSFERE 102
Cdd:PTZ00322  85 ELCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFG--ADPTLLDKD 147
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 67-92 5.41e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 5.41e-03
                           10        20
                   ....*....|....*....|....*.
gi 28927093     67 YDYTPLIIASLCGHYELVQLLLESGA 92
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
 
Name Accession Description Interval E-value
BACK_ABTB1_BPOZ cd18497
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 501-572 2.97e-29

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.


Pssm-ID: 350572  Cd Length: 72  Bit Score: 110.72  E-value: 2.97e-29
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28927093 501 VEPINVYDVIHAAWDLKVQRLEDFAARYLASRLEDYIDEEEFAELIQESASRLKRREETDTIELLDDIRYYL 572
Cdd:cd18497   1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 360-445 1.21e-20

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 87.74  E-value: 1.21e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 360 FPVHKAFLI-RSPYFETMFSSEFMEAKET-EHLHVIKV-DCLPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKL 436
Cdd:cd18296  29 FPCHKAFFCgRSDYFKALLRDHFAESEENnGSIPVVTLhDVSPEVFAIVLYYIYTDDTDLPPENAYDVLYVADMYLLPGL 108


                ....*....
gi 28927093 437 KTKAAVAIS 445
Cdd:cd18296 109 KRLCGTVLA 117
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-431 6.55e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 72.97  E-value: 6.55e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28927093 360 FPVHKAFL-IRSPYFETMFSSEFMEAKETE-HLHVIKvdclPEVLEIILTFLYTERSDCPLELALDLLYAADML 431
Cdd:cd18186  13 FPAHRAVLaARSPYFRAMFSSGMKESSSSEiELDDVS----PEAFEALLDYIYTGELELSEENVEELLAAADKL 82
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 148-232 1.25e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 66.42  E-value: 1.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 148 TDISLLTASESFHLHKFILSSRSPYFRRKFADA---PETSTWKLSHsIPVEAFRVVIRYLYLGELPRDLvgprstATEEE 224
Cdd:cd18186   2 CDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGmkeSSSSEIELDD-VSPEAFEALLDYIYTGELELSE------ENVEE 74


                ....*...
gi 28927093 225 VFKGIDKL 232
Cdd:cd18186  75 LLAAADKL 82
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 360-439 2.00e-13

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 66.90  E-value: 2.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093   360 FPVHKAFL-IRSPYFETMFSSeFMEAKETEHLHVIKVDclPEVLEIILTFLYTERSdCPLELALDLLYAADMLLLDKLKT 438
Cdd:pfam00651  22 FRAHKAVLaACSPYFKALFSG-QESESSVSEITLDDVS--PEDFEALLEFMYTGKL-ISEENVDDLLAAADKLQIPSLVD 97


                  .
gi 28927093   439 K 439
Cdd:pfam00651  98 K 98
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 360-439 2.87e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 66.18  E-value: 2.87e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093    360 FPVHKAFLI-RSPYFETMFSSEFMEAKETEhlhVIKVDCLPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKLKT 438
Cdd:smart00225  11 FHAHKAVLAaHSPYFKALFSSDFKESDKSE---IYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVE 87


                   .
gi 28927093    439 K 439
Cdd:smart00225  88 L 88
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 356-447 3.80e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 60.74  E-value: 3.80e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 356 RSVLFPVHKAFL-IRSPYFETMFSSEFMEAKETE-HLHVIKvdclPEVLEIILTFLYTERSDCPLELAL-DLLYAADMLL 432
Cdd:cd18286  25 DGKTFKAHRCILcARSSYFAAMLSGSWAESNSSEiTLTGVS----HAAVSFVLLFIYGGVLDLPDDVNLgELLSLADMYG 100

                        90
                ....*....|....*
gi 28927093 433 LDKLKTkaaVAISTL 447
Cdd:cd18286 101 LDGLKD---VVAYTL 112
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
3-97 8.77e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.43  E-value: 8.77e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093   3 LRKDQLELKLKDDEQLIRQGVLRNEHPFDDSPEFHefiHACRRGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYE 82
Cdd:COG0666  58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLH---AAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLE 134

                        90
                ....*....|....*
gi 28927093  83 LVQLLLESGalADPD 97
Cdd:COG0666 135 IVKLLLEAG--ADVN 147
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
39-117 3.18e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 3.18e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28927093  39 FIHACRRGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYELVQLLLESGALADPDSFERERAVYNALNNKIRNLL 117
Cdd:COG0666 157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-438 3.36e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 55.49  E-value: 3.36e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 357 SVLFPVHKAFL-IRSPYFETMFSSEFMEA-KETEHLHVIKvdclPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLD 434
Cdd:cd18256  29 MELFSVHRLVLaASSPYFAALFAGGMSESsKDVVQIHGVE----PDIFHILLDFIYTGVVEVTVSNVQELLVAADMLQLT 104


                ....
gi 28927093 435 KLKT 438
Cdd:cd18256 105 EVVE 108
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
40-97 3.90e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.43  E-value: 3.90e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 28927093  40 IHACRRGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYELVQLLLESGalADPD 97
Cdd:COG0666 125 HLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAG--ADVN 180
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 354-437 3.95e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 54.56  E-value: 3.95e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 354 PKRSVLFpVHKAFLI-RSPYFETMFSSEFMeaKETEHLHVIKVDCLPEVLEIILTFLYTERSDCPLELALDLLYAADMLL 432
Cdd:cd18294  23 PERQEIF-AHKCILAaRCEVFRAMFLTGPQ--KESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVLAAAVEYG 99


                ....*
gi 28927093 433 LDKLK 437
Cdd:cd18294 100 LDELR 104
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-446 4.43e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 54.85  E-value: 4.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 360 FPVHKAFLI-RSPYFETMFSSEfMEAKETEHLHVIKVDclPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKLKT 438
Cdd:cd18345  30 FQAHKAILAaRSPVFNAMFEHE-MEERKQNRVEITDVD--HEVMREMLRFIYTGKAPNLDKMADDLLAAADKYALERLKV 106


                ....*...
gi 28927093 439 KAAVAIST 446
Cdd:cd18345 107 MCEEALCS 114
Ank_2 pfam12796
Ankyrin repeats (3 copies);
39-89 5.87e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.58  E-value: 5.87e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 28927093    39 FIHACRRGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYELVQLLLE 89
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE 51
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 360-449 6.22e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 54.29  E-value: 6.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 360 FPVHKAFLI-RSPYFETMFSSEFMEAKETEHLHvikvdcLP---EVLEIILTFLYTErsDCP-------LELALDLLYAA 428
Cdd:cd18302  18 FPCHKCVLVaRLEYFHSMLSSSWIEASSCSALT------MPipsDILEIILDYLYTD--EASavkesqnVEFLCNVLVIA 89

                        90       100
                ....*....|....*....|.
gi 28927093 429 DMLLLDKLKTKAAVAISTLGS 449
Cdd:cd18302  90 DQLLITRLKEICEVALVELLS 110
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-441 6.80e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 54.63  E-value: 6.80e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 360 FPVHKAFLIR-SPYFETMFSSEFMEAKETE-----HLHvikvdclPEVLEIILTFLYTERSDCPLELALDLLYAADMLLL 433
Cdd:cd18254  34 FPCHRAVLAAcSRYFEAMFSNGLRESLDSTvnfhdSLH-------PEVLELLLDFAYSSRIIINEENAESLLEAGDMLQF 106


                ....*...
gi 28927093 434 DKLKTKAA 441
Cdd:cd18254 107 HDVRDAAA 114
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 142-212 2.69e-08

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 52.26  E-value: 2.69e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28927093   142 REIPKTTDISLLTASESFHLHKFILSSRSPYFRRKFADAPETSTWK--LSHSIPVEAFRVVIRYLYLGELPRD 212
Cdd:pfam00651   5 REQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSeiTLDDVSPEDFEALLEFMYTGKLISE 77
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 361-436 6.02e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 51.51  E-value: 6.02e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28927093 361 PVHKAFLIRSPYFETMFSSEFMEAKETE-HLHVIKVDCLPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKL 436
Cdd:cd18305  28 KLHKIYLCQSGYFASMFSGSWKESKETViNLEIPDDNITVEALNVVFGSLYRDEIEIKPSRVVSILAAATLLQLDGL 104
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 149-209 6.56e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 51.48  E-value: 6.56e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28927093 149 DISLLTASESFHLHKFILSSRSPYFRRKFadapeTSTWK------LSHS-IPVEAFRVVIRYLYLGEL 209
Cdd:cd18295  21 DVTFNVHGESFPAHRCILSARSPYFAEMF-----ETKWKdkreinLKHPlVNPDAFRALLQYLYTGRL 83
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-438 8.15e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 51.38  E-value: 8.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 360 FPVHKAFLI-RSPYFETMFSSEFMEAKETEhLHVIKVDclPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKLKT 438
Cdd:cd18279  30 FQAHKAILAaRSPVFSAMFEHEMEESKKNR-VEINDVD--PEVFKEMMRFIYTGKAPNLDKMADDLLAAADKYALERLKV 106
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-437 1.53e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 50.35  E-value: 1.53e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 360 FPVHKAFLI-RSPYFETMFSSEFMEAKETehlhVIKV-DCLPEVLEIILTFLYT---ERSDCPLELALDLLYAADMLLLD 434
Cdd:cd18297  24 FYAHKIVLVtASDRFKSMLSSGSTEAQTP----VIEIpDIRYDIFQLMMQYLYTggvESLDVAQDDALELLRAASFFQLD 99


                ...
gi 28927093 435 KLK 437
Cdd:cd18297 100 GLK 102
Ank_2 pfam12796
Ankyrin repeats (3 copies);
40-92 1.79e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.34  E-value: 1.79e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 28927093    40 IHACRRGDLKHCQELISGgVNINGKDkYDYTPLIIASLCGHYELVQLLLESGA 92
Cdd:pfam12796  35 HLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGA 85
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 134-225 2.18e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 50.02  E-value: 2.18e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 134 SHITSLLVREipKTTDISLLTASESFHLHKFILSSRSPYFRRKFAD-APETSTWKLS-HSIPVEAFRVVIRYLYLGELPR 211
Cdd:cd18280   3 QHFGALLESE--EGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGpMREENEGEIViEDVEPPVFKALLHFIYKDELPD 80

                        90
                ....*....|....*.
gi 28927093 212 D--LVGPRSTATEEEV 225
Cdd:cd18280  81 DvePAGSDSSSLDTTM 96
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 148-210 3.30e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 48.48  E-value: 3.30e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28927093 148 TDISLLTASESFHLHKFILSSRSPYFRRKFADAPETSTwKLSHSIP-----VEAFRVVIRYLYLGELP 210
Cdd:cd18283   3 TDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGA-EIPVDLPtagidVPMFSALLRYLYTGEFG 69
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-441 3.32e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 50.37  E-value: 3.32e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 360 FPVHKAFLIR-SPYFETMFSSEFMEAKETE-HLHvikvDCL-PEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKL 436
Cdd:cd18267  52 FPCHRAVLAAcSRYFEAMFSGGLKESQDSEvNFH----DSIhPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDI 127


                ....*
gi 28927093 437 KTKAA 441
Cdd:cd18267 128 RDACA 132
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 357-431 4.13e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 48.05  E-value: 4.13e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28927093 357 SVLFPVHKAFLIR-SPYFETMFSSEFMEAKETE-HLHVIKvdclPEVLEIILTFLYTERSDCPLELALDLLYAADML 431
Cdd:cd01165   7 GEKFHVNKELLAQsSEYFRALFRGGFRESGQAEiNLRDIS----PEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-438 4.29e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 49.36  E-value: 4.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 360 FPVHKAFLIR-SPYFETMFSSEFMEAKETE-HLHVIKvdclPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKLK 437
Cdd:cd18242  33 FPAHRIVLAAcSDYFCAMFTSEMSEKGKSEvELQGLT----ASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVK 108


                .
gi 28927093 438 T 438
Cdd:cd18242 109 Q 109
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 149-209 4.37e-07

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 48.46  E-value: 4.37e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28927093    149 DISLLTASESFHLHKFILSSRSPYFRRKFADAP---ETSTWKLSHsIPVEAFRVVIRYLYLGEL 209
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkesDKSEIYLDD-VSPEDFRALLNFLYTGKL 63
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-437 4.93e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 49.23  E-value: 4.93e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28927093 360 FPVHKAFLI-RSPYFETMFSSEFMEAKETEhLHVIKVDclPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKLK 437
Cdd:cd18343  33 FKAHKSILAaRSPVFNAMFEHEMEESKKNR-VEINDVD--PEVFKEMMRFIYTGKAPNLDKMADNLLAAADKYALERLK 108
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 360-437 5.45e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 48.11  E-value: 5.45e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28927093 360 FPVHKAFLI-RSPYFETMFSSEFMEAKETehlHVIKVDCLPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKLK 437
Cdd:cd18314  18 FFAHRIVLCaRSPVFRSMLTGSMIESNLK---EVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKYQVPDLE 93
Ank_4 pfam13637
Ankyrin repeats (many copies);
41-88 1.26e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.73  E-value: 1.26e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 28927093    41 HACRRGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYELVQLLL 88
Cdd:pfam13637   7 AAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 145-205 1.41e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 47.24  E-value: 1.41e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28927093 145 PKTTDISLLTASESFHL--HKFILSSRSPYFRRKFADAPETSTWKLSH---SIPVEAFRVVIRYLY 205
Cdd:cd18294  12 PEFSDVKFLVGPERQEIfaHKCILAARCEVFRAMFLTGPQKESTQSPLvlsDIEPEVFRAVLEFIY 77
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-436 1.47e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 47.86  E-value: 1.47e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28927093 360 FPVHKAFLI-RSPYFETMFSSEFMEAKEtEHLHVIKVDclPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKL 436
Cdd:cd18268  35 IPCHRNVLAsSSPYFRAMFCNNFRESSQ-AKVDLKGID--SDVLDQIVDYVYTGEILITRDNVLPLMEAASMLQYPKL 109
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 133-209 1.91e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 47.23  E-value: 1.91e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28927093 133 SSHITSLLVREipKTTDISLLTASESFHLHKFILSSRSPYFRRK-FADAPETSTWKLS-HSIPVEAFRVVIRYLYLGEL 209
Cdd:cd18287  10 SEDIGALFLNE--EYSDVTFVVEEKRFPAHRVILAARSEYFRALlYGGMRESQQSEIElKDTNAEAFKALLKYIYTGRL 86
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
40-131 3.48e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.18  E-value: 3.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093  40 IHACRRGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYELVQLLLESGALADPDSFERERAVYNALNNKIRNLLLS 119
Cdd:COG0666 191 HLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKL 270

                        90
                ....*....|..
gi 28927093 120 YDYTKTADPLQA 131
Cdd:COG0666 271 LLLALLLLAAAL 282
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 148-208 3.83e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 45.23  E-value: 3.83e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28927093 148 TDISLLTASESFHLHKFILSSRSPYFRRKFADapeTSTWKLS----HSIPVEAFRVVIRYLYLGE 208
Cdd:cd18315   2 VDVTLACEGGSLKAHKLVLAAASPYFAALLKE---TPPDEHPviilPDVPYSELKALLDFIYTGE 63
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 146-212 7.47e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 45.71  E-value: 7.47e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28927093 146 KTTDISLLTASESFHLHKFILSSRSPYFRRKFAD---APETSTWKLsHSIPVEAFRVVIRYLYLG--ELPRD 212
Cdd:cd18286  16 EDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGswaESNSSEITL-TGVSHAAVSFVLLFIYGGvlDLPDD 86
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-434 7.59e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 45.36  E-value: 7.59e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28927093 359 LFPVHKAFLIR-SPYFETMFSSEFMEAKEtEHLHVIKVDclPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLD 434
Cdd:cd18238  26 SIHCHRLVLACvSPYFRAMFTSEMAESKQ-DSITIKDID--EEAVELLVDFAYTGKLTLTVDNVQSLLYAASLLQVE 99
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-439 8.54e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 45.40  E-value: 8.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 357 SVLFPVHKAFLIR-SPYFETMFSSEFMEAKEtehlHVIKV-DCLPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLD 434
Cdd:cd18240  26 GVEFPAHRNILCAcSPYFRALFTNGWNETEK----KVYKIpGVSPEMMELIIEYAYTRTVPITAENVEELLPAADQFNIM 101


                ....*
gi 28927093 435 KLKTK 439
Cdd:cd18240 102 GIVKA 106
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-446 1.04e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 45.48  E-value: 1.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 360 FPVHKAFLI-RSPYFETMFSSEFMEAKETEhlhVIKVDCLPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKLKT 438
Cdd:cd18342  34 FQAHKAILAaRSPVFSAMFEHEMEESKKNR---VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKV 110


                ....*...
gi 28927093 439 KAAVAIST 446
Cdd:cd18342 111 MCEDALCS 118
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 361-437 1.13e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 44.54  E-value: 1.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 361 PVHKAFLI-RSPYFETMFSSEFMEAKETE-HLHVIKVDCLPEVLEiiltFLYTERSDCPLEL-ALDLLYAADMLLLDKLK 437
Cdd:cd18300  22 PAHKALLVaRCDVMAAMFGGNFRESSAKEvELPGVSKETFLALLE----YLYTDQAPILEDGdCVGLIVLANRLCLPRLV 97
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-431 1.80e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 44.76  E-value: 1.80e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28927093 360 FPVHKAFLIR-SPYFETMFSSEFMEAKETE-HLHvikvDCLPEVLEIILTFLYTERSDCPLELALDLLYAADML 431
Cdd:cd18250  33 FPCHRTVLAAaSSYFRAMFAGELRESRADRvVLH----GVSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLF 102
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 360-446 1.92e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 44.39  E-value: 1.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 360 FPVHK-AFLIRSPYFETMFSSEFMEaKETEHLHVIKVDClpEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKLKT 438
Cdd:cd18352  25 FYAHRiALLASSDAFRAMFDGGYRE-KEARDIEIPNIRW--EVFELMMRFIYTGSVDITNDIAKDLLRAADQYLLEGLKR 101


                ....*...
gi 28927093 439 KAAVAIST 446
Cdd:cd18352 102 LCEYTIAQ 109
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-411 2.59e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 44.22  E-value: 2.59e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 28927093 360 FPVHKAFLIR-SPYFETMFSSEFMEAKETeHLHVIKVDclPEVLEIILTFLYT 411
Cdd:cd18270  38 FPCHKMVLATcSSYFRAMFMSGLSESKQT-HVHLRNVD--AATLQIIITYAYT 87
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 143-210 2.75e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 44.18  E-value: 2.75e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 143 EIPKTTDISLLTASESFHLHKFILSSRSPYFRRKFADAPETSTWKLS--HSIPVEAFRVVIRYLYLGELP 210
Cdd:cd18344  19 ENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIeiHDLDPQVFKEMMGFIYTGKAP 88
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-438 1.14e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 41.94  E-value: 1.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 360 FPVHKAFL-IRSPYFETMFSSEFMEaKETEHLHVIKVDCLPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKLKT 438
Cdd:cd18245  26 IPVQKNVLaAASPYFRAKLNYNPPK-DDGSTYKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQAADLLLMTDLKD 104
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 148-213 1.33e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 41.99  E-value: 1.33e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28927093 148 TDISLLTASESFHLHKFILSSRSPYFR---RKFadAPETSTWKLS--HSIP-VEAFRVVIRYLYLGEL---PRDL 213
Cdd:cd18309  21 CDITLLLDGHPIPAHKAILAARCSYFEamfRSF--MPEDNTVNISigEMVPsRQAFDSLLRYIYYGDVtmpPEDS 93
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 141-210 1.50e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 42.10  E-value: 1.50e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28927093 141 VREIPKTTDISLLTASESFHLHKFILSSRSPYFRRKFA-DAPETSTWKLS-HSIPVEAFRVVIRYLYLGELP 210
Cdd:cd18276  15 MKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTcGLMECSQREVVlHDITAESVSIILNYMYSSDLH 86
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 149-209 1.53e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 41.72  E-value: 1.53e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28927093 149 DISLLTASESFHLHKFILSSRSPYFRRKFADAPETSTWKLsHSIPVEAFRVVIRYLYLGEL 209
Cdd:cd18260  20 DLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQRVEL-NDISPLGLATVITYAYTGKL 79
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 149-205 1.56e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 41.12  E-value: 1.56e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28927093 149 DISLLTASESFHLHKFILSSRSPYFRRKFADAPETSTWKLSH------SIPVEAFRVVIRYLY 205
Cdd:cd18301  20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAVGCdvvhieKVPPEIFEQLLQFIY 82
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 156-212 1.57e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 40.73  E-value: 1.57e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 156 SESFHLHKFILSSRSPYFRRKFAD---APETSTWKLSHsIPVEAFRVVIRYLYLGELPRD 212
Cdd:cd01165   7 GEKFHVNKELLAQSSEYFRALFRGgfrESGQAEINLRD-ISPEDFRALLEFLYGGKRDLD 65
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 142-209 1.61e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 41.56  E-value: 1.61e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28927093 142 REIPKTTDISLLTASESFHLHKFILSSRSPYFRRKFADAP---ETSTWKLSH-SIPVEAFRVVIRYLYLGEL 209
Cdd:cd18245   9 REEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPpkdDGSTYKIELeGISVEVMEEILDYIYTGQI 80
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 145-245 1.63e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 41.43  E-value: 1.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 145 PKTTDISLLTA-SESFHLHKFILSSRSPYFRRKFADapETsTWKLSHSIPVEAFRVVIRYLYLGELprdlvgprstATEE 223
Cdd:cd18299  10 PSCADVVFILQgGVRIFAHRIVLAAASSVFADLFLM--MT-VVTLDSDITPEAFRRVLEFLYTGVL----------DENE 76

                        90       100
                ....*....|....*....|..
gi 28927093 224 EVFKGIDKLCKQLEIAHLWEAV 245
Cdd:cd18299  77 DDLKELKDAAELLELFDLVMMC 98
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 146-233 1.91e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 40.79  E-value: 1.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 146 KTTDISLLTASESFHLHKFILSSRSPYFRRKFADAPETSTWKlshSIPVEA-----FRVVIRYLYLGEL---PRDLVGPR 217
Cdd:cd18314   5 EFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLK---EVTLEDvepeiFETVLKYMYTGQVtlsEENVLDLL 81

                        90
                ....*....|....*.
gi 28927093 218 STATEEEVfKGIDKLC 233
Cdd:cd18314  82 MLASKYQV-PDLEKLC 96
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-431 2.52e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 41.36  E-value: 2.52e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28927093 360 FPVHKAFLIR-SPYFETMFSSEFMEAKETEhLHVIKVDclPEVLEIILTFLYTERSDCPLELALDLLYAADML 431
Cdd:cd18340  39 FPCHRLVLAAcSPYFRAMFLSDLEESKKRE-IVLEDVD--PDVMGKILHYIYTSEIEITEQNVQDIFAAANMF 108
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 149-209 2.71e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 41.12  E-value: 2.71e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28927093 149 DISLLTASESFHLHKFILSSRSPYFRRKFADAPETSTWKLS--HSIPVEAFRVVIRYLYLGEL 209
Cdd:cd18238  17 DVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSItiKDIDEEAVELLVDFAYTGKL 79
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 149-209 2.95e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 41.17  E-value: 2.95e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28927093 149 DISLLTASESFHLHKFILSSRSPYFRRKFADAPEtSTWKLSHSIPVEAFRVVIRYLYLGEL 209
Cdd:cd18289  31 DVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSK-SAFELPATVPPACFQQILSFCYTGKL 90
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 145-207 3.02e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 40.72  E-value: 3.02e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28927093 145 PKTTDISLLTASESFHLHKFILSSRSPYFRRKFADAPETS---TWKLSHsIPVEAFRVVIRYLYLG 207
Cdd:cd18297  10 PEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAqtpVIEIPD-IRYDIFQLMMQYLYTG 74
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 133-210 3.13e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 40.98  E-value: 3.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 133 SSHITSLLVREipKTTDISLLTASESFHLHKFILSSRSPYFRRKFADAPETStwKLS----HSIPVEAFRVVIRYLYLGE 208
Cdd:cd18279   6 AEDLGNLWENS--RFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEES--KKNrveiNDVDPEVFKEMMRFIYTGK 81


                ..
gi 28927093 209 LP 210
Cdd:cd18279  82 AP 83
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-418 3.14e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 40.94  E-value: 3.14e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 360 FPVHKAFLIR-SPYFETMFSSEFMEAKETEhlhVIKVDCLPEVLEIILTFLYTerSDCPL 418
Cdd:cd18276  33 FPCHRLVLAAfSPYFKAMFTCGLMECSQRE---VVLHDITAESVSIILNYMYS--SDLHL 87
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 148-209 3.21e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 41.14  E-value: 3.21e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28927093 148 TDISLLTASESFHLHKFILSSRSPYFRRKFADAPETSTWKLSHSIPVEA--FRVVIRYLYLGEL 209
Cdd:cd18270  27 TDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAatLQIIITYAYTGNL 90
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 38-102 3.77e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.73  E-value: 3.77e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28927093   38 EFIHACRRGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYELVQLLLESGalADPDSFERE 102
Cdd:PTZ00322  85 ELCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFG--ADPTLLDKD 147
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-140 3.93e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 43.02  E-value: 3.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093   8 LELKLKDDEQLIRQGVLRNEHPFDDSPEFHEFIHACRRGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYELVQLL 87
Cdd:COG0666  27 AAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLL 106

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28927093  88 LESGALADPDSFERERAVYNALNN---KIRNLLLSYDytktADPLQAWSSHITSLL 140
Cdd:COG0666 107 LEAGADVNARDKDGETPLHLAAYNgnlEIVKLLLEAG----ADVNAQDNDGNTPLH 158
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-441 3.93e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 41.35  E-value: 3.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 359 LFPVHKAFLIR-SPYFETMFSSEFMEAK-ETEHLHvikvDCLPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKL 436
Cdd:cd18273  45 LFPCNRNVLAAaSPYFKSMFTGGLYESKqETVTIH----DVDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYV 120


                ....*
gi 28927093 437 KTKAA 441
Cdd:cd18273 121 REACA 125
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 16-122 4.11e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 43.50  E-value: 4.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093   16 EQLIRQGVLRNEHPFDDSPEFHefIHACRRGDLKHCQE----LISGGVNINGKDKYDYTPLIIASLC--GHYELVQLLLE 89
Cdd:PHA03100  52 KILLDNGADINSSTKNNSTPLH--YLSNIKYNLTDVKEivklLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLD 129

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 28927093   90 SGALADPDSFERERAV-----YNALNNKIRNLLLSYDY 122
Cdd:PHA03100 130 NGANVNIKNSDGENLLhlyleSNKIDLKILKLLIDKGV 167
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 145-210 5.06e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 40.38  E-value: 5.06e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28927093 145 PKTTDISLLTASESFHLHKFILSSRSPYFRrkFADAPETSTWKLShSIPVEAFRVVIRYLYLGELP 210
Cdd:cd18303  16 ELYSDITIKLADKSIPAHKFVLAARSEKWS--NENLASTNELDLS-DISYEVVLALLRWLYTDELD 78
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 143-210 5.07e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 40.37  E-value: 5.07e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 143 EIPKTTDISLLTASESFHLHKFILSSRSPYFRRKFADAPETSTWKLSH--SIPVEAFRVVIRYLYLGELP 210
Cdd:cd18343  17 ENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEinDVDPEVFKEMMRFIYTGKAP 86
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 146-210 5.40e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 40.39  E-value: 5.40e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28927093 146 KTTDISLLTASESFHLHKFILSSRSPYFRRKFaDAPETSTWKLSHSIP---VEAFRVVIRYLYLGELP 210
Cdd:cd18240  16 KLCDVVIRVNGVEFPAHRNILCACSPYFRALF-TNGWNETEKKVYKIPgvsPEMMELIIEYAYTRTVP 82
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 148-205 5.95e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 39.62  E-value: 5.95e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28927093 148 TDISLLTASESFHLHKFILSSRSPYFRRKFADAPETSTWKLS-HSIP--VEAFRVVIRYLY 205
Cdd:cd18312  10 SDITVRVGNTTFHLHKFPLCSKSGYFKRLASSSSESDPSEIElNDFPggAEAFELVAKFCY 70
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-413 6.20e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 40.58  E-value: 6.20e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 28927093 360 FPVHKAFL-IRSPYFETMFSSEFMEAKETEhLHVIKVDclPEVLEIILTFLYTER 413
Cdd:cd18259  44 FPCHRSVLaLCSHYFNAMFTGDFVESISAR-VEIKDVD--PAVMESLIDFAYTGK 95
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-431 6.34e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 40.47  E-value: 6.34e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28927093 360 FPVHKAFLIR-SPYFETMFSSEFMEAKETEhLHVIKVDclPEVLEIILTFLYTERSDCPLELALDLLYAADML 431
Cdd:cd18269  39 FPCHRLVLAAcSPYFRAMFLSDLEESKKKE-VVLEDVD--PDVMGMILKYLYTSEIDLNDQNVQDIFALASRF 108
Ank_5 pfam13857
Ankyrin repeats (many copies);
57-95 6.48e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.10  E-value: 6.48e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 28927093    57 GGVNINGKDKYDYTPLIIASLCGHYELVQLLLESGALAD 95
Cdd:pfam13857   5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLN 43
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 160-209 6.48e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 40.75  E-value: 6.48e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 160 HLHKFILSSRSPYFRRKFADAPETST-----WKLSHSIPV-----EAFRVVIRYLYLGEL 209
Cdd:cd18310  32 PVHRCILAARSPFFRDIFASAKAEGAntkpkLELRELIPGgivgyDAFMLVLSYLYSGRL 91
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 145-215 6.75e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 39.54  E-value: 6.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 145 PKTTDISLLTASESFHLHKFILSSRSPYFRRKFADapetsTWK---------LSHSIPVeaFRVVIRYLYLGEL---PRD 212
Cdd:cd18298  10 PRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQS-----HWNeddknvieiDQYSYPV--YYAFLRYLYTDQVdlpPED 82


                ...
gi 28927093 213 LVG 215
Cdd:cd18298  83 AIG 85
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 370-438 7.02e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 39.96  E-value: 7.02e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 370 SPYFETMFSSEFMEAKETE-HLHVIKvdclPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKLKT 438
Cdd:cd18247  42 IPYFHAMFTHDMVESKQDEiTMQGIE----PSALEALINFAYSGRIAIDTSNVQSLLVGASFLQLQSVKD 107
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 358-434 7.59e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 40.06  E-value: 7.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 358 VLFPVHKAFLIR-SPYFETMFSSEF----MEAKETEHLHvikvdclPEVLEIILTFLYTERSDCPLELALDLLYAADMLL 432
Cdd:cd18248  35 EEFMAHKVVLASsSPYFKAMFTSGLrecgMEVVPIEGVH-------PCVMSRLIEFAYTASISVGEKCVLHVLPGAVMYQ 107


                ..
gi 28927093 433 LD 434
Cdd:cd18248 108 MD 109
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 146-241 7.88e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 39.97  E-value: 7.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 146 KTTDISL-LTASESFHLHKFILSSRSPYFRRKFADAPETSTWKLSHSIPVEA--FRVVIRYLYLGELPRDLVGPRSTATE 222
Cdd:cd18274  21 QLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAesMHLVLDYAYTSRVTLTEANVQALFTA 100

                        90       100
                ....*....|....*....|.
gi 28927093 223 EEVFK--GIDKLCKQLEIAHL 241
Cdd:cd18274 101 ASIFQipSLQDQCAQFMISRL 121
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 31-128 8.18e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.56  E-value: 8.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093   31 DDSPEFHEFIHacRRGDLKHCqeLISGGVNINGKDKYDYTPLIIA-SLCGHYELVQLLLESGALADPDSFEREravYNAL 109
Cdd:PHA02878 201 NNSPLHHAVKH--YNKPIVHI--LLENGASTDARDKCGNTPLHISvGYCKDYDILKLLLEHGVDVNAKSYILG---LTAL 273

                         90       100
                 ....*....|....*....|....
gi 28927093  110 NNKIR-----NLLLSYDytktADP 128
Cdd:PHA02878 274 HSSIKserklKLLLEYG----ADI 293
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-437 9.49e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 39.94  E-value: 9.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 360 FPVHKAFLI-RSPYFETMFSSEfMEAKETEHLHVIKVDclPEVLEIILTFLYTERSDC--PLELALDLLYAADMLLLDKL 436
Cdd:cd18344  35 FRAHKAILAaRSPVFRAMFEHE-MEERLKNPIEIHDLD--PQVFKEMMGFIYTGKAPHlhSHSMACDVLAAADKYGLEGL 111


                .
gi 28927093 437 K 437
Cdd:cd18344 112 K 112
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 149-209 1.01e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 39.39  E-value: 1.01e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28927093 149 DISLLTASESFHLHKFILSSRSPYFRRKFADAPETSTWKLS---HSIPVEAFRVVIRYLYLGEL 209
Cdd:cd18293  17 DVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVlelQGLKAHTLLKLVDFLYTSEL 80
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 42-113 1.02e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.90  E-value: 1.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28927093   42 ACRRGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYELVQLLLESGalADPDSFERERAV----YNALNNKI 113
Cdd:PHA02875 142 AVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSG--ANIDYFGKNGCVaalcYAIENNKI 215
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 362-437 1.09e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 39.16  E-value: 1.09e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28927093 362 VHKAFL-IRSPYFETMFSSEFMEAKEtehlHVIKVDCLP-EVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKLK 437
Cdd:cd18353  34 VHKAVLkIRCEHFRTMFQSHWNEDMK----EVIEIDQFSyPVYRAFLEYLYTDSVDLPPEDAIGLLDLATSYCENRLK 107
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 358-433 1.60e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 38.95  E-value: 1.60e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28927093 358 VLFPVHKAFLIR-SPYFETMFSSEFMEAKeTEHLHVIKVDclPEVLEIILTFLYTERSDCPLELALDLLYAADMLLL 433
Cdd:cd18235  31 VEIPAHRVVLAScSPYFHAMFTGDLSESR-ANRVTLQDVD--GKALLLLIDYVYTAEIQVTEENVQVLLPAANLLQL 104
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 145-235 1.74e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 38.77  E-value: 1.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 145 PKTTDISLLTASESFHLHKFILSSRSPYFRRKFADAPETSTWKLSHSIPVeaFRVVIRYLYLGEL---PRDLVGPRSTAT 221
Cdd:cd18354  18 PDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPV--YRAFLEYLYTDSIslsPEDAIGLLDLAT 95

                        90
                ....*....|....*.
gi 28927093 222 --EEEVFKgidKLCKQ 235
Cdd:cd18354  96 fyRENRLK---KLCQQ 108
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 54-92 2.01e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.19  E-value: 2.01e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 28927093   54 LISGGVNINGKDKYDYTPLIIASLCGHYELVQLLLESGA 92
Cdd:PHA03100 178 LLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGA 216
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 360-443 2.16e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 38.38  E-value: 2.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 360 FPVHKAFL-IRSPYFETMFSSEFMEAKET--EHLHVikvdcLPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKL 436
Cdd:cd18295  31 FPAHRCILsARSPYFAEMFETKWKDKREInlKHPLV-----NPDAFRALLQYLYTGRLEIHVDDVEDCKRLAKQCRLEEL 105


                ....*..
gi 28927093 437 KTKAAVA 443
Cdd:cd18295 106 IEELEAK 112
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 135-213 2.46e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 38.53  E-value: 2.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 135 HITSLL-----VREIPKTTDISLLTASESFHLHKFILSSRSPYFRRKFADAPETSTWKLSHSIPVEA--FRVVIRYLYLG 207
Cdd:cd18255   1 HSVTLLqglnaLRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAkgLKHILDFAYTS 80


                ....*.
gi 28927093 208 ELPRDL 213
Cdd:cd18255  81 ELTLDL 86
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 148-216 3.25e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 38.23  E-value: 3.25e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28927093 148 TDISLLTASESFHLHKFILSSRSPYFRRKFADAPETSTWKLSH--SIPVEAFRVVIRYLYLGE--LPRDLVGP 216
Cdd:cd18268  24 TDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDlkGIDSDVLDQIVDYVYTGEilITRDNVLP 96
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-431 3.46e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 38.24  E-value: 3.46e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28927093 360 FPVHKAFL-IRSPYFETMFSSEFMEAKETE-HLHVIKvdclPEVLEIILTFLYTERSDCPLELALDLLYAADML 431
Cdd:cd18264  40 FPAHRSLLaCSSDYFRALFKDYTQESKARViHLPVVS----AAGLQRVLDFIYTSWLSLSLDTLEDTLEAASYL 109
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-434 3.47e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 37.73  E-value: 3.47e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28927093 360 FPVHKAFL-IRSPYFETMFSSEFMEAKETEhlhVIKVDCLPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLD 434
Cdd:cd18234  13 IPAHRLVLsAVSDYFAAMFTNDVREATEEE---IKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLLQLS 85
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-413 3.63e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 37.89  E-value: 3.63e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 28927093 360 FPVHKAFLIR-SPYFETMFSSEFMEAKETehLHVIKvDCLPEVLEIILTFLYTER 413
Cdd:cd18253  30 FPCHRAILSAcSSYFRAMFCNDHRESREM--LVEIN-GILAEAMDCFLQYVYTGK 81
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 35-108 3.68e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 40.33  E-value: 3.68e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28927093   35 EFHEFIH-ACRRGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYELVQLLLESGALADPDSFERERAVYNA 108
Cdd:PHA02874 123 ELKTFLHyAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNA 197
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 357-416 3.70e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 37.27  E-value: 3.70e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28927093 357 SVLFPVHKAFL-IRSPYFETMFSSEFMEAKET---EHLHVIKVDclPEVLEIILTFLYTerSDC 416
Cdd:cd18301  27 GKTFPAHKFILaSRSDYFRKLFLSSLLTSEDAvgcDVVHIEKVP--PEIFEQLLQFIYT--DTC 86
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 149-209 5.05e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 37.38  E-value: 5.05e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28927093 149 DISLLTASESFHLHKFILSSRSPYFRRKFADA-PETSTWKLS-HSIPVEAFRVVIRYLYLGEL 209
Cdd:cd18256  22 DVQLQVGMELFSVHRLVLAASSPYFAALFAGGmSESSKDVVQiHGVEPDIFHILLDFIYTGVV 84
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 11-92 5.25e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.05  E-value: 5.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093   11 KLKDDE---QLIRQGVLRNEHPFDDSPEFHEFIHACR----RGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYEL 83
Cdd:PHA02876 114 KHKLDEaciHILKEAISGNDIHYDKINESIEYMKLIKeriqQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKM 193


                 ....*....
gi 28927093   84 VQLLLESGA 92
Cdd:PHA02876 194 VNLLLSYGA 202
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 67-92 5.41e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 5.41e-03
                           10        20
                   ....*....|....*....|....*.
gi 28927093     67 YDYTPLIIASLCGHYELVQLLLESGA 92
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 145-214 6.09e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 37.27  E-value: 6.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 145 PKTTDISLLTASESFHLHKFILSSRSPYFRRKFAD--------APETSTWKLsHSIPVEAFRVVIRYLYLG--ELPRDLV 214
Cdd:cd18296  15 LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDhfaeseenNGSIPVVTL-HDVSPEVFAIVLYYIYTDdtDLPPENA 93
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 146-209 6.18e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 37.14  E-value: 6.18e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28927093 146 KTTDISLLTASESFHLHKFILSSRSPYFRRKFAdAPETSTWKLSHSIPVEAFRVVIRYLYLGEL 209
Cdd:cd18200  17 KFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLL-LNDTNCLVLPSVIEAAAFENLLQLIYSGRL 79
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 42-95 6.51e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 39.85  E-value: 6.51e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 28927093   42 ACRRGDLKHCQELISGGVNINGKDKYDYTPLIIASLCGHYELVQLLLESGALAD 95
Cdd:PLN03192 629 AAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVD 682
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 363-437 7.55e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 37.32  E-value: 7.55e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28927093 363 HKAFLIR-SPYFETMFSSEFMEAKETehlHVIKVDCLPEVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKLK 437
Cdd:cd18246  54 HKVVLAScSPYFHAMFTNEMSESRQT---HVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVR 126
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 362-439 7.78e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 36.46  E-value: 7.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28927093 362 VHKAFL-IRSPYFETMFSSEFMEAKETehlhVIKVDCLP-EVLEIILTFLYTERSDCPLELALDLLYAADMLLLDKLKTK 439
Cdd:cd18298  26 VHKAILkIRCEYFRSMFQSHWNEDDKN----VIEIDQYSyPVYYAFLRYLYTDQVDLPPEDAIGLLDLANSYCEERLKKL 101
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 149-209 9.98e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 36.71  E-value: 9.98e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28927093 149 DISLLTASESFHLHKFILSSRSPYFRRKFADAPETSTWKLS--HSIPVEAFRVVIRYLYLGEL 209
Cdd:cd18263  15 DVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVqlPTIPAKDLRLLISFAYSGIL 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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