|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
1-425 |
3.26e-144 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 417.73 E-value: 3.26e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 1 MDKKIFRLALPNIITNITVPLLGMIDIAVAGRLGSAVYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAM 80
Cdd:cd13136 1 LHREILALALPAILSNITVPLLGLVDTAVVGHLGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 81 SVFIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAI 160
Cdd:cd13136 81 ALLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 161 LNNILNIVLSVCFVFGLGMSIEGIALGTTLSQIISLIVAAILWHKYYGRLRKYIQKdKIWKRQVIREYFRVNGDIFVRTF 240
Cdd:cd13136 161 VGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSR-RLPSKAALKRLFKLNRDIFIRTL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 241 LLTLVTTFFTFASSGMGDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFFWGLMVSVLAM 320
Cdd:cd13136 240 ALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 321 TIYTLFPDLILRLLTNDTFIIAETKSYMFWTLMIPFAGFAAFLWDGIFIGATASSEMRNAMIISSIIFFTSYFLLTPTWA 400
Cdd:cd13136 320 LLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSLAVFLPLLFLLVPLWG 399
|
410 420
....*....|....*....|....*
gi 697633888 401 NNALWFSFIVYLAARGITLTIMARK 425
Cdd:cd13136 400 NHGLWLALILFMLLRGLTLALRLPR 424
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
3-422 |
5.23e-80 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 253.53 E-value: 5.23e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGSAvYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSV 82
Cdd:COG0534 8 KLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTA-ALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 83 FIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILN 162
Cdd:COG0534 87 LGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 163 NILNIVLSVCFVFGLGMSIEGIALGTTLSQIISLIVAAILWHKYYGRLRkYIQKDKIWKRQVIREYFRVNGDIFVRTFLL 242
Cdd:COG0534 167 NVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLR-LRLRDLRPDRKILKRILRIGLPAGLQQLAE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 243 TLVTTFFTFASSGMGDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFFWGLMVSVLAMTI 322
Cdd:COG0534 246 SLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 323 YTLFPDLILRLLTNDTFIIAETKSYMFWTLMIPFAGFAAFLWDGIFIGATASSEMRNAMIISSIIFF--TSYFLLTPTWA 400
Cdd:COG0534 326 LFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRlpLAYLLAFLGLG 405
|
410 420
....*....|....*....|..
gi 697633888 401 NNALWFSFIVYLAARGITLTIM 422
Cdd:COG0534 406 LTGVWLALPIGEVLRALLLLLR 427
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
2-425 |
9.57e-78 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 248.11 E-value: 9.57e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 2 DKKIFRLALPNIITNITVPLLGMIDIAVAGRLGSAVYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMS 81
Cdd:PRK10367 8 DKALWRLALPMIFSNITVPLLGLVDTAVIGHLDSPVYLGGVAVGATATSFLFMLLLFLRMSTTGLTAQAFGAKNPQALAR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 82 VFIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAIL 161
Cdd:PRK10367 88 ALVQPLLLALGAGALIALLRTPLIDLALHIVGGSEAVLEQARRFLEIRWLSAPASLANLVLLGWLLGVQYARAPVILLVV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 162 NNILNIVLSVCFVFGLGMSIEGIALGTTLSQIISLIV-AAILWHKYYGRLRKYIQKDKIWkRQVIREYFRVNGDIFVRTF 240
Cdd:PRK10367 168 GNILNIVLDLWLVMGLHMNVQGAALATVIAEYATLLIgLLMVRKVLKLRGISLEMLKTAW-RGNFRRLLALNRDIMLRSL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 241 LLTLVTTFFTFASSGMGDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFFWGLMVSVLAM 320
Cdd:PRK10367 247 LLQLCFGAITVLGARLGSDIIAVNAVLMTLLTFTAYALDGFAYAVEAHSGQAYGARDGSQLLDVWRAACRQSGIVALLFS 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 321 TIYTLFPDLILRLLTNDTFIIAETKSYMFWTLMIPFAGFAAFLWDGIFIGATASSEMRNAMIISSIIFFTSYFLLtPTWA 400
Cdd:PRK10367 327 LVYALAGEHIIALLTSLPQIQQLADRYLIWQVILPLVGVWCYLLDGMFIGATRAAEMRNSMAVAAAGFALTLLTL-PWLG 405
|
410 420
....*....|....*....|....*
gi 697633888 401 NNALWFSFIVYLAARGITLTIMARK 425
Cdd:PRK10367 406 NHGLWLALTVFLALRGLSLAAIWRR 430
|
|
| GntT_guanitoxin |
NF041358 |
guanitoxin biosynthesis MATE family efflux transporter GntT; |
6-427 |
3.06e-67 |
|
guanitoxin biosynthesis MATE family efflux transporter GntT;
Pssm-ID: 469250 [Multi-domain] Cd Length: 438 Bit Score: 220.67 E-value: 3.06e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 6 FRLALPNIITNITVPLLGMIDIAVAGRLGSAVYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSVFIR 85
Cdd:NF041358 16 FRLAIANVLSNIMVPLAGLISVAFLGHLSEIHHLAGVALAGNLFDYLYRILAFLRMGTTGVTAQAVGRDDREAMLLVGLR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 86 SLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILNNIL 165
Cdd:NF041358 96 NGLIALVLGILILLLQYPLRELGFALLSATPEVKASGIAYFNARIWGAPAVLLNFVLIGWFLGREKNGLVVLLSVIGNAA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 166 NIVLSVCFVFGLGMSIEGIALGTTLSQIISLIVAAIL------WHKyygrLRKYIQkdKIWKRQVIREYFRVNGDIFVRT 239
Cdd:NF041358 176 NIALDYLLIIRWGWESTGAGLSYAISQYLTLLVGLIFvcleikWQE----LRAVAG--KIWDRSAIKSTFTLNGNIFVRN 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 240 FLLTLVTTFFTFASSGMGDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFFWGLMVSVLA 319
Cdd:NF041358 250 LIFISALLIFTNESAAMGTIIYAENALLLQIIFLSVYFIEGLGFATETLTGNFKGKGASEQLVPLVKVSVGTSLLVGLSF 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 320 MTIYTLFPDLILRLLTNDTFIIAETKSYMFWTLMIPFAGFAAFLWDGIFIGATASSEMRNAMIISSII-FFTSYFLLTPT 398
Cdd:NF041358 330 AGVCVLFPQTVFGLLTNHTEITEQIDIYVPWLLPVLGFSSIAFMLEGYFLGLAEGHTLRNVSLIALTVgFIPLAIAAWYF 409
|
410 420
....*....|....*....|....*....
gi 697633888 399 WANNALWFSFIVYLAARGITLTIMARKTF 427
Cdd:NF041358 410 HSNHILWLALSLFMIIRMVALGVQLPRTF 438
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
11-352 |
2.89e-46 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 162.80 E-value: 2.89e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 11 PNIITNITVPLLGMIDIAVAGRLGSaVYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSVFIRSLAIG 90
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGP-VDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 91 LGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILNNILNIVLS 170
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 171 VCFVFGL--GMSIEGIALGTTLSQIISLIVaAILWHKYYGRLRKYIQKDKIWKRQVIREYFRVNGDIFVRTFLLTLVTTF 248
Cdd:TIGR00797 160 YILIFGKfgFLGIVGAALATVISYWLMFLL-LLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 249 FTFASSGMGDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFFWGLMVSVLAMTIYTLFPD 328
Cdd:TIGR00797 239 LALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFRE 318
|
330 340
....*....|....*....|....
gi 697633888 329 LILRLLTNDTFIIAETKSYMFWTL 352
Cdd:TIGR00797 319 FIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
3-425 |
1.31e-40 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 149.98 E-value: 1.31e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGSaVYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSV 82
Cdd:cd13133 5 REILKIALPLVLSMLSQTVMGFTDRAFLGRLSE-VALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 83 FIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILN 162
Cdd:cd13133 84 LWQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 163 NILNIVLSVCFVFGLG----MSIEGIALGTTLSQIISLIVAAIL-----WHKYYGRLRKYiqkdkIWKRQVIREYFRVNG 233
Cdd:cd13133 164 VVVNIVLDYALIFGKLgfpaMGIAGAAIATVIAEAVSLLFFLLLlfrrkNRRRFGLRRAW-----RFDRELLRRILRLGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 234 DIFVRTFLLTLVTTFFTFASSGMGDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFFWGL 313
Cdd:cd13133 239 PSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLAL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 314 MVSVLAMTIYTLFPDLILRLLTNDT---FIIAETKSYMFWTLMIPFAGFAAFLWDGIFIGA--TASSeMRNAMIISSIIF 388
Cdd:cd13133 319 AYMLLLGILFLLFPELLLSIFTPGAdfaLIAELAVPLLRFVAAYILFDALALVFAGALRGAgdTRFV-MLAELIVAWLYL 397
|
410 420 430
....*....|....*....|....*....|....*...
gi 697633888 389 FTSYFLLTPTWAN-NALWFSFIVYLAARGITLTIMARK 425
Cdd:cd13133 398 LPPAYLLVVLGAGlAGAWTVETVYVIVLALIFLLRFRS 435
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
3-425 |
2.71e-39 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 146.50 E-value: 2.71e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGSAVyIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSV 82
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEA-IAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 83 FIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILN 162
Cdd:cd13137 80 LGQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 163 NILNIVLSVCFVFGL----GMSIEGIALGTTLSQIISLIV-AAILWHKYYGRLRKYiqKDKIWKRQVIREYFRVNGDIFV 237
Cdd:cd13137 160 NVLNIVLDYVLIFGLwgfpGLGVAGAALATVISRVVGALLlLFLLLRGRLPIKISF--KGFRLDRKIIKKLLRIGLPAGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 238 RTFLLTLVTTFFTFASSGMGDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFFWGLMVSV 317
Cdd:cd13137 238 EQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 318 LAMTIYTLFPDLILRLLTNDTFIIAETKSYMFW-TLMIPFAGFaAFLWDGIFIGATASsemRNAMIISSI---------- 386
Cdd:cd13137 318 LLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIvALSQPFLAI-SFVLSGALRGAGDT---RPPLIINLIsmwlvrlpla 393
|
410 420 430
....*....|....*....|....*....|....*....
gi 697633888 387 IFFTSYFLLTPTWAnnalWFSFIVYLAARGITLTIMARK 425
Cdd:cd13137 394 YLLGFVLGLGLTGI----WLAMFVDTIVRAILLLYRFRK 428
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
2-352 |
1.12e-36 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 139.17 E-value: 1.12e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 2 DKKIFRLALPNIITNITVPLLGMIDIAVAGRLGSAvYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMS 81
Cdd:cd13134 2 KLSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDN-AVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 82 VFIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAIL 161
Cdd:cd13134 81 IAGVALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 162 NNILNIVLSVCFVFGLG----MSIEGIALGTTLSQIISLIVAAILWHKYYgRLRKYIQKDKIWKRQVIREYFRVNGDIFV 237
Cdd:cd13134 161 MNILNIVGNYLLIFGWFglpkLGVAGVAISTVISRAVGLVLLFILLFRKL-KIRFRLKDLRPFPKKLLKKILKIGLPSAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 238 RTFLLTLVTTFFTFASSGMGDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFFWGLMVSV 317
Cdd:cd13134 240 EELSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSL 319
|
330 340 350
....*....|....*....|....*....|....*
gi 697633888 318 LAMTIYTLFPDLILRLLTNDTFIIAETKSYMFWTL 352
Cdd:cd13134 320 AVALLLALFREPILGLFTDDPEIIALGKTLLLISI 354
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
9-421 |
8.62e-31 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 122.82 E-value: 8.62e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 9 ALPNIITNITVPLLGMIDIAVAGRLGSAvYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSVFIRSLA 88
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGD-ALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 89 IGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILNNILNIV 168
Cdd:cd12082 80 LAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 169 LSVCFVFGLG---MSIEGIALGTTLSQIISLIVAAILWhKYYGRLRKYIQKDKIWKRQVIREYFRVNGDIFVRTFLLTLV 245
Cdd:cd12082 160 LDPLLIFGLGppeLGIAGAALATVISYVIGALLLLIYL-RKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 246 TTFFT-FASSGMGDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFFWGLMVSVLAMTIYT 324
Cdd:cd12082 239 LLIIVaIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLIL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 325 LFPDLILRLLTNDTFIIAETKSYMFWTLMIPFAGFAAFLWDGIFIGA--TASSEMRNAMIISSIIFFTSYFLLTPTWANN 402
Cdd:cd12082 319 LFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAgrTLKSLIVSLLSYWVVRLPLAYVLAYLGLGLY 398
|
410
....*....|....*....
gi 697633888 403 ALWFSFIVYLAARGITLTI 421
Cdd:cd12082 399 GIWLALVISLILAALVLLL 417
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
3-421 |
6.89e-30 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 120.30 E-value: 6.89e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGSAVyIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSV 82
Cdd:cd13131 3 RALLRLALPILIAQLAQMAMGFVDTVMAGRLGADD-LAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRRA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 83 FIRSLAIGLGIGFIIILMQYpIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILN 162
Cdd:cd13131 82 VRQGLWLALLLSLPLMLLLW-LAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 163 NILNIVLSVCFVFGLG----MSIEGIALGTTLSQIISLIVAAILWHKYYgRLRKYIQKDKIWK--RQVIREYFRVNGDIF 236
Cdd:cd13131 161 LVLNIPLNYVLIFGKFglpaLGGAGAGLATAIVYWLMFLALAFYIRRHK-RFRRYRLFARFWRpdWARLKELLRLGLPIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 237 VRTFLLTLVTTFFTFASSGMGDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFFWGLMVS 316
Cdd:cd13131 240 LTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 317 VLAMTIYTLFPDLILRLLTNDTFIIAETKSYMFWTLMIPFAGFAAFLWDGIFIGATassEMRNAMIISSIIFF-----TS 391
Cdd:cd13131 320 ALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYK---DTRVPFLLALISYWgiglpLG 396
|
410 420 430
....*....|....*....|....*....|.
gi 697633888 392 YFLLTPT-WANNALWFSFIVYLAARGITLTI 421
Cdd:cd13131 397 YLLAFTTgLGAFGVWIGLIIGLALAAILLLW 427
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
3-371 |
7.24e-27 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 111.78 E-value: 7.24e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGSAVYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSV 82
Cdd:cd13138 3 KTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 83 FIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILN 162
Cdd:cd13138 83 VGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVIIA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 163 NILNIVLSVCFVFGLGMSIEGIALGTTLSQIISLIVA--AILWHKYYGRLRKyiqKDKIWKRQVIREYFRVNGDIFVRTF 240
Cdd:cd13138 163 CVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLAlyYLRKKKLPFKLSL---KDFRFDKEILKEILKIGLPSALQQS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 241 LLTLVTTFFTFASSGMGDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFFWGLMVSVLAM 320
Cdd:cd13138 240 LVSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIII 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 697633888 321 TIYTLFPDLILRLLTNDTFIIAETKSYMFWTL--MIPFAGFAAFlwDGIFIGA 371
Cdd:cd13138 320 LLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSidYILFGILFVF--NGLFRGL 370
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
3-408 |
8.10e-27 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 111.45 E-value: 8.10e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGSAVYIGAIALGANIFNMIywnFGFLRMSSSGFA---SQAYGARDFSEA 79
Cdd:cd13143 4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALAAVNLVFPIIMLL---MALGLMIGVGGAsliSRRLGAGDREKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 80 MSVFIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIA 159
Cdd:cd13143 81 NRIFSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 160 ILNNILNIVLSVCFVFGLGMSIEGIALGTTLSQIISLIVAAILWHKYYGRLRKYIQKDKIWKRqVIREYFRVNGDIFVRT 239
Cdd:cd13143 161 LIGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLK-IIKEILALGFPSFLMQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 240 FLLTLVTTFFTFASSGM-GDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFFWGLMVSVL 318
Cdd:cd13143 240 LSSSVVTIVLNLTLLGYgGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 319 AMTIYTLFPDLILRLLTNDTFIIAETKSYMFWT-LMIPFAGFaAFLWDGIFigaTASSEMRNAMIISS----IIFFTSYF 393
Cdd:cd13143 320 LFLILLLFPEQIVSLFTDDPELIALAARILRIFlLAFPLAGI-NIVLSGYF---QAIGKAKRAALLSLlrqgLFLIPLLL 395
|
410
....*....|....*
gi 697633888 394 LLTPTWANNALWFSF 408
Cdd:cd13143 396 ILPRLFGLDGIWLAF 410
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
3-350 |
1.93e-20 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 92.97 E-value: 1.93e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGSaVYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSV 82
Cdd:cd13140 5 KTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGS-DAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARKY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 83 FIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHV-KTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAIL 161
Cdd:cd13140 84 ARNALQLNLLLGILYGLLLLLFAKPLIGFFNLGDAEVISLaITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINAI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 162 NNILNIVLSVCFVFGLG----MSIEGIALGTTLSQIISLIVAAILWHKYYGRLRKYIQKDKIwKRQVIREYFRVNGDIFV 237
Cdd:cd13140 164 GLVLNIILDPLLIFGFGpfpaLGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRP-DRKYIKEILKLGLPVAL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 238 RTFLLTLVTTFFTFASSGMGDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFFWGLMVSV 317
Cdd:cd13140 243 QSILFALISMILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAIGL 322
|
330 340 350
....*....|....*....|....*....|...
gi 697633888 318 LAMTIYTLFPDLILRLLTNDTFIIAETKSYMFW 350
Cdd:cd13140 323 FATLLLFFFGEPLFSLFIPDPETIAIGVDYLRI 355
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
3-410 |
2.38e-19 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 89.94 E-value: 2.38e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGsAVYIGAIALGAN-IFNMIYWNFGFlrmSSSGFA--SQAYGARDFSEA 79
Cdd:cd13142 11 RTLLKLAWPIIVSNLLQVAYNLADTFWLGRLG-ADAVAAPSISWPlIFLFISLGGGL---TVAGTAlvAQYTGAGDYDKA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 80 MSV----FIRSLAIGLGIGFIIILMQYPigeLAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIP 155
Cdd:cd13142 87 NKVagqtFSFVIILSLILAVLGYILSRP---LLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 156 MVIAILNNILNIVLSVCFVFGLG----MSIEGIALGTTLSQIISLIVAAILWHKYYGRLRKYIqKDKIWKRQVIREYFRV 231
Cdd:cd13142 164 MKIMFGSVLLNVILDPLLIFGIGpfpgLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKISL-RDLKPDWEWLKKIFRI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 232 NGDIFVR--------TFLLTLVTTFFTFASSGMGdtilaINALLMQFFMLFSyfmDGFAYAGEALTGRYIGAKNRSMLRY 303
Cdd:cd13142 243 GLPSSIEqsaralgfTVMTALVAGFGTVVVAAYG-----IGNRIISLVFLPA---FGLARATSTMVGQNLGAGQIDRAEE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 304 MIKRIFFWGLMVSVLAMTIYTLFPDLILRLLTNDTFIIAETKSYMFWTLmIPFAGFAAF-LWDGIFIGataSSEMRNAMI 382
Cdd:cd13142 315 IVKKAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVA-PSFPFFGLFqVINGAFRG---SGHTLTAMI 390
|
410 420 430
....*....|....*....|....*....|....
gi 697633888 383 ISSI------IFFTSYFLLTPTWANNALWFSFIV 410
Cdd:cd13142 391 ISILrlwvirIPLAYLLAYVLGLGVTGIWIAMAI 424
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
3-357 |
7.59e-19 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 88.12 E-value: 7.59e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLgSAVYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSV 82
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRI-SIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 83 FIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILN 162
Cdd:cd13135 80 AISSIVYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 163 NILNIVLSVCFVFG-LG---MSIEGIALGTTLSQIISLIVAAILWHKYYGRLRKYIQKDKIWKRqvIREYFRVngdifVR 238
Cdd:cd13135 160 NLLNVILDYVLIFGnFGfprLGIIGAAIATTIANVLNLIILVYLCRKIKKLTFKLSNTKVLKAN--IRPYKFT-----IK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 239 TFLLTLVTTFFTFAS--------SGMGDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFF 310
Cdd:cd13135 233 LGLPLGGEEFLWNIGnlavirilNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLG 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 697633888 311 WGLMVSVLAMTIYTLFPDLILRLLTNDTFIIAETKSYMFWTLMIPFA 357
Cdd:cd13135 313 LGLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFF 359
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
3-399 |
4.36e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 80.05 E-value: 4.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGSAVyIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSV 82
Cdd:cd13141 11 KHIISMALPIAIGMIIQTLYFLVDLYFVGQLGDAA-LAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEANAV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 83 FIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRiviWGAPAVL---GMYAFKGWFIGMQNARIPMVIA 159
Cdd:cd13141 90 FNQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLY---WFIPSLAlqfILTVLGAALRGTGIVKPFMVIQ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 160 ILNNILNIVLSVCFVFGLG----MSIEGIALGTTLSQIISLIVAAIlwhkYYGRLRKYIQKDkiwkrqviREYFRVNGDI 235
Cdd:cd13141 167 ILAVLLNIILAPILITGWGtgraLGVAGAGLASSISVAIAVVLLLY----YFLRLEKYLRLD--------LALWRPDLPT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 236 FVR----------TFLLTLVTT---------FFTFASSGMGdtilaINALLMQffMLFSYFMdGFAYAGEALTGRYIGAK 296
Cdd:cd13141 235 WKRllkiglpsggEFLLTFVYMaviywalrpFGAAAQAGFG-----IGSRIMQ--SLFLPAM-AIAFAAPAIAGQNFGAG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 297 NRSMLRYmikrIFFWGLMVSVLAMTIYTL----FPDLILRLLTNDTFIIAETKSYMFWTLMIPFAGFAAFLWDGIFIG-- 370
Cdd:cd13141 307 NYDRVRE----TFRITAILTTALMLVLTLlcqlVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQAlg 382
|
410 420 430
....*....|....*....|....*....|....*
gi 697633888 371 ----ATASSEMRNAMIISSIIFF--TSYFLLTPTW 399
Cdd:cd13141 383 ntwpSLLSSASRLLTFALPVIWLsaQPDFRIEQIW 417
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
11-170 |
6.61e-15 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 71.83 E-value: 6.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 11 PNIITNITVPLLGMIDIAVAGRLGSaVYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSVFIRSLAIG 90
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGA-VALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 91 LGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILNNILNIVLS 170
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
2-349 |
2.80e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 74.19 E-value: 2.80e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 2 DKKIFRLALPNIITNITVPLLGMIDIAVAGRLGsAVYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMS 81
Cdd:cd13139 13 NRAIFLLAIPMVLEMVMESLFAVVDLYFVSRLG-ALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGAGF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 82 VFIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAIL 161
Cdd:cd13139 92 AAVQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 162 NNILNIVLSVCFVFGLG----MSIEGIALGTTLSQIISLIVAaiLWHKYYGRLRKYIQKDKI-WKRQVIREYFRVN---- 232
Cdd:cd13139 172 ANGLNIILDPLFIFGLGpipaMGVTGAAIATTIGRSIGVLYQ--LYHLFKGKGRIQIRRRHLkLDWAIIKKIIKIAvggi 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 233 GDIFVRT----FLLTLVTTFFTFASSGMgdtILAINalLMQFFMLFSYfmdGFAYAGEALTGRYIGAKNRSMLRYMIKRI 308
Cdd:cd13139 250 LQFLIASsswiFLVRIIAEFGSTALAGY---TIAIR--IIMFALLPAW---GLSNAAATLVGQNLGAGQPDRAEKSVWRA 321
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 697633888 309 FFWGLMVSVLAMTIYTLFPDLILRLLTNDTFIIAETKSYMF 349
Cdd:cd13139 322 GKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALR 362
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
3-395 |
7.76e-13 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 69.91 E-value: 7.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGSaVYIGAIALGANIFNMIywNFGFLRMSSSG---FASQAYGARDFSEA 79
Cdd:cd13132 3 KKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGK-LELAAASLASSFANVT--GFSILLGLASAldtLCGQAFGAKNYKLV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 80 MSVFIRSLAIGLGIGFIIILMqYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIA 159
Cdd:cd13132 80 GVYLQRALVILLLCCVPISLL-WLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYIS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 160 ILNNILNIVLSVCFVFGLGMSIEGIALGTTLSQIISLIV--AAILWHKYYgrlrkyiqkdKIWKRQVIREYFRVNGdIFV 237
Cdd:cd13132 159 LVALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLllLYIFFSKGH----------KATWGGFSREAFRGWG-PFL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 238 R-----TFLLTLVTTFF---TFASSGMGDTI-LAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRI 308
Cdd:cd13132 228 KlaipsALMLCLEWWAFeilVLLAGLLPGTVaLAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVA 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 309 FFWGLMVSVLAMTIYTLFPDLILRLLTNDTFIIAETKSymfwtlMIPFAGFaAFLWDGifIGATASSEMRNA--MIISSI 386
Cdd:cd13132 308 LILSLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVAD------LLPILAL-FQIFDG--LQAVLSGVLRGCgrQKLGAY 378
|
....*....
gi 697633888 387 IFFTSYFLL 395
Cdd:cd13132 379 VNLVAYYLI 387
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
235-387 |
1.08e-11 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 62.58 E-value: 1.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 235 IFVRTFLLTLVTTFFTFASSGMGDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFFWGLM 314
Cdd:pfam01554 2 IALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLL 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 697633888 315 VSVLAMTIYTLFPDLILRLLTNDTFIIAETKSYMFWTLMIPFAGFAAFLWDGIFIGATASSEMRNAMIISSII 387
Cdd:pfam01554 82 LSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLL 154
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
3-203 |
1.88e-11 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 65.42 E-value: 1.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGSAVYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSV 82
Cdd:cd12082 219 RRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRI 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 83 FIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILN 162
Cdd:cd12082 299 TWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLS 378
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 697633888 163 NILNIVLSVCFVFGLGMSIEGIALGTTLSQIISLIVAAILW 203
Cdd:cd12082 379 YWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLLLFF 419
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
3-367 |
1.27e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 59.86 E-value: 1.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMID-IAVAGRLGSAVYigAIALGANIFnMIYWNFGF-LRMSSSGFASQAYGARDFSEAM 80
Cdd:cd13147 9 KAIIKLSIPMIIAMLLQTLYNLVDaIWVAGLGADALA--AIGFVFPLF-MIIIGLGNgLGAGASSAISRRIGAKDKEGAD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 81 SVFIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGpESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAI 160
Cdd:cd13147 86 NAAVHSILLGLIISIILTIVLLPFLEPILVLMGAG-EVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 161 LNNILNIVLSVCFVFGLGMSIEGIALGTTLSQIISLIVAAI-LWHK--YYGRLRKYIQKdkiWKRQVIREYFRVNGDIFV 237
Cdd:cd13147 165 AGSILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLLYwFFVKkdTYVSLSLKNFK---FDKKIVKDILKVGIPASL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 238 RTFLLTLVTTFFT-FASSGMGDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKN----RSMLRYMIKriffWG 312
Cdd:cd13147 242 EQLIMSVLMIILNlILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNyeklKTAYNYSIK----LG 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 697633888 313 LMVSVLAMTIYTLFPDLILRLLT---NDTFIIAETKSYM----FWTLMIPFAGFAAFLWDGI 367
Cdd:cd13147 318 LIIELIIAILIFIFAPQIAYLFTyseESAHLAPEIVAFLrimcLFLPFVPFGMMSSSMFQGI 379
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
3-206 |
4.95e-09 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 57.85 E-value: 4.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGSAVyIGAIALGANI---FNMIYWNFGflrMSSSGFASQAYGARDFSEA 79
Cdd:cd13138 225 KEILKIGLPSALQQSLVSISFLIINSIVNSYGVVA-SAAYGIANKInsfAFLPPSAIG---QAVSTFVAQNIGAGKIERA 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 80 MSVFIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIA 159
Cdd:cd13138 301 KKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIIS 380
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 697633888 160 ILNN-ILNIVLSVCFVFGLGMSIEGIALGTTLSQIISLIVAAILWHKY 206
Cdd:cd13138 381 ILRLwLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKG 428
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
3-425 |
1.41e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 53.39 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGSaVYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSV 82
Cdd:cd13144 8 RLLLTMSIPAMISMLFQALYNIVDSIFVARLGE-NALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANKA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 83 FIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILN 162
Cdd:cd13144 87 ANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 163 NILNIVLSVCFVFGL----GMSIEGIALGTTLSQIISLIVAailwhkyygrLRKYIQKDKIWKRQVI--REYFRVNGDIF 236
Cdd:cd13144 167 AIINIILDPILIFGLfgfpAMGIAGAAIATVIGQILAMFLA----------FFFLLRKNKDVQPDLRlfRPSLRIIKEIY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 237 VRTFLLTLVTTFFTFASSGMGDTILAINALLMQFFMLFS-----YFMDGFAYAGEAL--TGRYIGAKNRSMLRYMIKRIF 309
Cdd:cd13144 237 AVGLPSIIMQAISSVMVFGLNKILAGFGPTAVAVFGIYFklqsfVFMPVFGLNNGLIpiVAYNYGAGNKDRIREAIKYAI 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 310 FWGLMVSVLAMTIYTLFPDLILRLLT-NDTFIIAETKSYMFWTLMIPFAGFAAFLWdGIFIGATASsemRNAMIISS--- 385
Cdd:cd13144 317 LIAVVIMLAGGLLFQLFPDQLLGLFNaSEEMLAIGVPALRIISLSFLFAALSIILS-GLFQALGRG---VYSLIISVarq 392
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 697633888 386 -IIFFTSYFLLTPTWANNALWFSFIVYLAARGITLTIMARK 425
Cdd:cd13144 393 lVVLLPLAWLLAKMFGLNGVWWSFPIAEIVSFLLSLLFLKR 433
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
3-426 |
3.47e-07 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 52.12 E-value: 3.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLgSAVYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSV 82
Cdd:PRK01766 12 RQLLALALPILLAQVAQTAMGFVDTVMAGGV-SATDLAAVAIGTSIWLPVILFGHGLLLALTPIVAQLNGAGRRERIAHQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 83 FIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILN 162
Cdd:PRK01766 91 VRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVIGFLG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 163 NILNIVLSVCFVFG------LGMSIEGIALGTTLsQIISLIVAAILWHKYygRLRKYIQKDKIWK--RQVIREYFRVNGD 234
Cdd:PRK01766 171 LLINIPLNYIFIYGkfgfpeLGGVGCGVATAIVY-WVMFLAMLIYIKRAR--RFRDFRLFKGLYKpdWAVIKRLLKLGLP 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 235 IFVRTFLLTLVTTFFTFASSGMGDTILAINALLMQF----FML-FSyfmdgfayAGEALT---------GRYIGAKNRSM 300
Cdd:PRK01766 248 IGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFssllFMLpLS--------LAMALTirvgfelgaGRTLDARQYAY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 301 LRYMIkriffwGLMVSVLAMTIYTLFPDLILRLLTNDTFIIAETKSYMFwtlmipfagFAAF--LWDGIfigATASS--- 375
Cdd:PRK01766 320 IGLAV------GLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLL---------FAALfqFSDAI---QVIGSgal 381
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 697633888 376 ----EMRNAMIISSIIFF-----TSYFL-LTPTWANNALWFSFIVYLAARGITLTIMARKT 426
Cdd:PRK01766 382 rgykDTRVIFFITFIAYWvlglpLGYILaLTDPMGPFGFWIGLIIGLTAAAILLLLRLRKL 442
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-337 |
3.98e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 52.02 E-value: 3.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 5 IFRLALPNIITNITVPLLGMIDIAVAGRL--GSAVYIGAIALGANIFnMIYWNFGF-LRMSSSGFASQAYGARDFSEAMS 81
Cdd:cd13146 10 LIRLALPILIGQLFQLLYNITDTIWISMIdpSDPALVGGIGLVFPLG-MIFLALGNgIQVGVSSLLARAIGAQRAKELDQ 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 82 VFIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAIL 161
Cdd:cd13146 89 AADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 162 NNILNIVLSVCFVFGLGMSIEGIALGTTLSQIISLIVAAILWHKYYGRLRKYIQKDKIWKrQVIREYFRVNGDIFVRTFL 241
Cdd:cd13146 169 GTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHIKLSNISS-SVIVEILRVGLPQMLLQLI 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 242 LTLVTTFFTFassgmgdTILAINALLMQFFMLFSYF-----MDGFAYAGEALT--GRYIGAKNRSMLRYMIKRIFFWGLM 314
Cdd:cd13146 248 SSISFLIYNR-------IIIDIDPVAMTAFTLVGRLdqfilIPIFAISSALLTiaGQNWGRGNYDRMLQILMTAVILGIV 320
|
330 340
....*....|....*....|...
gi 697633888 315 VSVLAMTIYTLFPDLILRLLTND 337
Cdd:cd13146 321 VVLVLVLGYVLVAPWLFSLFTTV 343
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-362 |
4.01e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 51.89 E-value: 4.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 5 IFRLALPNIITNITVPLLGMIDIAVAGRLGSAVyIGAIALGANIFN-MIYWNFGFLRMSSSGFASQAYGARDFSEAMSVF 83
Cdd:cd13148 14 LLRLALPNILALLVQTLVGLAETYFVGQLGTDA-LAGVALVFPLLMlTQMMSNGAMGGGVSSAIARALGAGDRERAEALV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 84 IRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILNN 163
Cdd:cd13148 93 WHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALVTLVGA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 164 ILNIVLSVCFVFGLG----MSIEGIALGTTLSQIISLIVaaILWHKYYGRLR-KYIQKDKIWKRQVIREYFRVNGDIFVR 238
Cdd:cd13148 173 VVQIPLSPGLILGWGplprLGVAGAAVAAVLYYALAALV--LLRYLASGRSRlRLRLRALRLERRLFRDILRVGLLAALS 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 239 TFLLTLVTTFFTFASSGMGDTILA---INALLmQFFMLFSYFmdGFAYAGEALTGRYIGAKNRSMLRymikRIFFWG-LM 314
Cdd:cd13148 251 PLQTNLTVLLLTGLVGRFGTAALAgygIGSRL-EFLLIPLVF--GLGAAMTAMVGMNIGAGQIARAR----RIAWTGaLM 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 697633888 315 VSVLAMTI---YTLFPDLILRLLTNDTFIIAETKSYMFWtlMIPFAGFAAF 362
Cdd:cd13148 324 AAVLAGAIglvLALFPELWLGLFTHDPAVLAAGASYLRI--VGPFYGFFGL 372
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
3-203 |
4.83e-07 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 51.66 E-value: 4.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGSAVyIGAIALgANIFNM-IYWNFGFLRMSSSGFASQAYGARDFSEAMS 81
Cdd:PRK10189 29 REITPLAVPIFIENLCVLLMGVLSTFLVSWLGKEA-MAGVGL-ADSFNMvIMAFFAAIDLGTTVVVAFSLGKRDRRRARA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 82 VFIRSLAIGLGIGFIIILMQYPIGELAFKFIKSgpESVNHVK----TYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMV 157
Cdd:PRK10189 107 AARQSLVIMTLFAVLLAVLIHFFGEQIIDLVAG--DATPEVKalalTYLELTVWSYPAAAITLIGSGALRGAGNTKIPLL 184
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 697633888 158 IAILNNILNIVLSVCFVFGL----GMSIEGIALGTTLSQIISLIvaAILW 203
Cdd:PRK10189 185 INGGMNILNIIISSILIYGLfswqGLGFVGAGLGLTISRYIGAV--AIIW 232
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
3-205 |
2.02e-06 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 49.76 E-value: 2.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGSAVyIGAIALGANIFNMIYWNFG-------FLRMSssgfasQAYGARD 75
Cdd:cd13123 215 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGS-ISALYYADRLYQLPLGIFGvaiatalLPRLS------RLAAAGD 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 76 FSEAMSVFIRSLAIGLGIG----FIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQN 151
Cdd:cd13123 288 LDEFRRTLSRGLRLVLFLLlpaaVGLIVLAEPIVRLLFERGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKD 367
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 697633888 152 ARIPMVIAILNNILNIVLSVCFVFGLGmsIEGIALGTTLSQIISLIVAAILWHK 205
Cdd:cd13123 368 TKTPVKIAVIAVAVNILLNLLLIKPLG--HVGLALATSLSAWVNALLLLVLLRR 419
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
3-396 |
3.03e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 49.22 E-value: 3.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGSAVYIGAIALGANIFNMIYWNFGfLRMSSSGFASQAYGARDFSEAMSV 82
Cdd:cd13149 9 RHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLNSLTIG-LGIGASAVISRAIGAGDRNKAKRL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 83 FIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILN 162
Cdd:cd13149 88 ATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVMLGA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 163 NILNIVLSVCFVFGLG----MSIEGIALGTTLSQIISLIvAAILWHKYYGRLrkyiqkdKIWKRQVIREYFRVNGDIF-- 236
Cdd:cd13149 168 ALVNVILDPILIFGFGpipgMGIAGAAIATVISRALGLG-AALYFLHYHHRL-------IDFSEPSLKALFRSWKDILsi 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 237 -------------VRTFLLTLVTTFFTFASSGMGdTILAINALLMQFFMLFSYFMDGFayagealTGRYIGAKN----RS 299
Cdd:cd13149 240 gipaalsniltplSAAFITALVATYGPAAVAAFG-VATRIESFAFIIVMALSSALGPF-------VGQNWGAGQyervQE 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 300 MLRYMIKRIFFWGLMVSVlamtIYTLFPDLILRLLTNDTFIIAETKSYMFWtLMIPFAGFaaflwdGIFIGATASSEMRN 379
Cdd:cd13149 312 GLKISLKFSLIYGAILGI----VLALFAGWLASLFSAEPEVIELITLYLLI-VPIGYGGL------GILIITSASFNALG 380
|
410
....*....|....*..
gi 697633888 380 AMIISSIIFFTSYFLLT 396
Cdd:cd13149 381 KPLYSLGLNLIRVFLLY 397
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
3-210 |
3.67e-06 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 48.99 E-value: 3.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLG----SAVY-----------IGAIALGANIFNMIywnfgflrmsssgfa 67
Cdd:COG0728 222 RRVLKLMLPALLGVSVSQINLLVDTILASFLPegsvSALYyadrlyqlplgLFGVAIGTALLPRL--------------- 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 68 SQAYGARDFSEAMSVFIRSLAIGLGIG----FIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFK 143
Cdd:COG0728 287 SRAAAAGDLEEFRRTLSRGLRLVLLLTlpaaVGLIVLAEPIVRLLFERGAFTAEDTALTALALAAYALGLPAFALVKVLA 366
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 697633888 144 GWFIGMQNARIPMVIAILNNILNIVLSVCFVFGLGmsIEGIALGTTLSQIISLIVAAILWHKYYGRL 210
Cdd:COG0728 367 RAFYARQDTRTPVRIAVIAVVVNIVLNLLLVPPLG--HAGLALATSLSALVNALLLLVLLRRRLGGL 431
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
1-205 |
4.85e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 48.66 E-value: 4.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 1 MDKKIFRLALPNIITNITVPLLGMIDIAVAGRLGSAVyIGAIALGANIFNMIYW-NFGFlRMSSSGFASQAYGARDFSEA 79
Cdd:cd13137 224 IIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAA-LAAYQIGLRIESLAFMpGFGF-SMAASTLVGQNLGAGDPDEA 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 80 MSVFIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIA 159
Cdd:cd13137 302 RRYGKRALRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIIN 381
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 697633888 160 ILNNILN-IVLSVCFVFGLGMSIEGIALGTTLSQIISLIVAAILWHK 205
Cdd:cd13137 382 LISMWLVrLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRK 428
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-348 |
1.97e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 46.82 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 5 IFRLALPNIITNITVPLLGMIDIAVAGRLgSAVYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSVFI 84
Cdd:cd13145 11 IRKLAIPASVGFFFNTMFNVVDTFFAGKI-STEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 85 RSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILNNI 164
Cdd:cd13145 90 QGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 165 LNIVLSVCFVFG----LGMSIEGIALGTTLSQIISLIVaailwhkyygrLRKYIQKDKIWKRQVIREY---FRVNGDIFV 237
Cdd:cd13145 170 LNIILDPLFIFGgggiPAMGVSGIALATIISQFIGMFY-----------LLYKVRKSGIISGCRLRDFiprLDVYKEILK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 238 RTF-----LLTLVTTFF--TFASSGMGDTILA---INALLMQFFMLFSYfmdGFAYAGEALTGRYIGAKNRSMLRYMIKR 307
Cdd:cd13145 239 QGFpaslnMMTIGLGIFviTYFVGQFGDEAVAaygIALRIEQILLLPTI---GLNTAVLSIAGQNFGAKKYDRVRETYKK 315
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 697633888 308 IFFWGLMVSVLAMTIYTLFPDLILRLLTNDTFIIAETKSYM 348
Cdd:cd13145 316 ALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGYL 356
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
3-209 |
1.03e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 44.44 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGsAVYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSV 82
Cdd:cd13140 231 KEILKLGLPVALQSILFALISMILARIIASFG-PVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKG 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 83 FIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIViwgAPAVLGM---YAFKGWFIGMQNARIPMVIA 159
Cdd:cd13140 310 YKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRIL---GFSQLFMcleITTTGAFNGLGRTKPPAIIS 386
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 697633888 160 ILNNILNIVLSVcFVFGLGMSIEGIALGTTLSQIISLIVAAILWHKYYGR 209
Cdd:cd13140 387 IVFNGLRIPLAL-LLSPTGLGLNGIWWAISISSILKGIILTIWFLLYKKK 435
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
5-200 |
1.20e-04 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 44.17 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 5 IFRLALPNIITNITVPLLGMIDIAVAGRLGSAVYIGAIALGANIFNMIYWNFGFLRMSSSGFASQAYGARDFSEAMSVFI 84
Cdd:COG2244 175 VLKYSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYR 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 85 RSLAIGLGIGFIIILMQYPIGELAFKFIksGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILNNI 164
Cdd:COG2244 255 KALRLLLLLGLPLALGLALLAPPLLSLL--FGPEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAV 332
|
170 180 190
....*....|....*....|....*....|....*.
gi 697633888 165 LNIVLSVCFVFGLGmsIEGIALGTTLSQIISLIVAA 200
Cdd:COG2244 333 LNLVLNLLLIPRYG--LVGAAIATLLSYLVLLLLLL 366
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
103-278 |
2.60e-04 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 43.08 E-value: 2.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 103 PIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILNNILNIVLSVCFVFGLGMSie 182
Cdd:TIGR01695 327 PIVSLLFERGAFSEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRTPFINSVISVVLNALLSLLLIFPLGLV-- 404
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 183 GIALGTTLSQIISlivAAILWHKYYGRLRKYIQkdkiwkRQVIREYFR-VNGDIFVRTFLLTLVTTFFTFASSGMGDTIL 261
Cdd:TIGR01695 405 GIALATSAASMVS---SVLLYLMLNRRLKGILP------FGVLKVLAKlVIASAIIGGVLYLIVSVSLGGVLVKNLLGLL 475
|
170
....*....|....*..
gi 697633888 262 AINALLMQFFMLFSYFM 278
Cdd:TIGR01695 476 AIGLIGLLVYFLGLALL 492
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
122-340 |
4.87e-04 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 42.14 E-value: 4.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 122 VKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILNNILNIVLSVCFVFgLGMSIEGIALGTTLSQIISLIVAAI 201
Cdd:cd13128 108 LVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILALILVL-LGGGLIGFALAYLIASVLSAILLLY 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 202 LWHKYYGRLRKYIQKDKIWKRqVIRE-------------YFRVNGdIFVRTFLLTLVTTFFTFASSGMGDTILAINALLM 268
Cdd:cd13128 187 IYRKKILLPKFFSFDLKLAKE-LLRFsiplalsgifsliYTRIDT-IMLGYFLGDAAVGIYNAAYRIAELLLFIPSAIST 264
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 697633888 269 QFFMLFSYFMdgfayagealtgryigAKNRSMLRYMIKRIFFWGLMVSVLAMTIYTLFPDLILRLLTNDTFI 340
Cdd:cd13128 265 ALFPRISELY----------------KNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYL 320
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
125-346 |
1.99e-03 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 40.36 E-value: 1.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 125 YFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILNNILNIVLSVCFVFGLGMSIEGIALGTTLSQIISLIVAAILWH 204
Cdd:PRK09575 134 YIQVLIWGCLFTLGAIALPFLLRNDESPNLATGLMVIGALINIVLDYLFIGWLDWGLTGAAIATALAQLVVTVLGLGYFF 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 205 KYYGRLRKYIQKdkiwkrqvireyFRVNGDIFVRTFLLTlVTTFFTFAssgMGDTILAI-NALLMQF------------- 270
Cdd:PRK09575 214 SSRANIRLTLKE------------LRFNWSLAPKIVLLG-SSSFFMYL---YGSFVVALhNRLFMEYgsaltvgayaivg 277
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 697633888 271 --FMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFFWGLMVSVLAMTIYTLFPDLILRLLTN-DTFIIAETKS 346
Cdd:PRK09575 278 ylMVLYYLVAEGIAEGMQPPVSYYFGARQYDNIKKLLKLAMKVTVLAGIAWVLLLNLFPETMIALFNSgDSELIAETIV 356
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
103-216 |
2.05e-03 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 40.35 E-value: 2.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 103 PIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILNNILNIVLSVCFVFGLGMSie 182
Cdd:pfam03023 301 PIVSLLFERGNFSPEDVTATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKISLISAVLNILLSLLLLPPLGVA-- 378
|
90 100 110
....*....|....*....|....*....|....
gi 697633888 183 GIALGTTLSqiiSLIVAAILWHKYYGRLRKYIQK 216
Cdd:pfam03023 379 GLALATSLS---SLIGLVFLYYILRKRLGGFDLR 409
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
3-399 |
4.47e-03 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 39.16 E-value: 4.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 3 KKIFRLALPNIITNITVPLLGMIDIAVAGRLGSAVYIGAIALGANIFNMIywnfgflrMSSSGFASQAYGARDFSEAMSV 82
Cdd:COG2244 2 KKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALL--------SVLADLGLSTALVRFIAEYREE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 83 FIRSLAIGLGIGFIIILMQYPIGELAFKFIKSGPESVNHVKTYFRIVIWGAPAVLGMYAFKGWFIGMQNARIPMVIAILN 162
Cdd:COG2244 74 ELRRLLSTALLLRLLLSLLLALLLLLLAPFIAALLGEPELALLLLLLALALLLSALSAVLLALLRGLERFKLLALINILS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 163 NILNIVLSVCFVFgLGMSIEGIALGTTLSQIISLIVAAILWhkyygrlrkyiqkdkiwkrqvireyfrvNGDIFVRTFLL 242
Cdd:COG2244 154 SLLSLLLALLLAL-LGLGLWGLVLKYSLPLLLSGLLGLLLT----------------------------NLDRLLLGALL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 697633888 243 tlvttfftfassgmGDTILAINALLMQFFMLFSYFMDGFAYAGEALTGRYIGAKNRSMLRYMIKRIFFWGLMVSVLAMTI 322
Cdd:COG2244 205 --------------GPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALG 270
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 697633888 323 YTLFPDLILRLLTNDTFiiAETKSYMFWTLMIPFAGFAAFLWDGIFIGATASSEMRNAMIISSIIFFTSYFLLTPTW 399
Cdd:COG2244 271 LALLAPPLLSLLFGPEY--AEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRY 345
|
|
| |
