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Conserved domains on  [gi|681104565|emb|CDZ74824|]
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Acetate kinase [Peptoniphilus sp. ING2-D1G]

Protein Classification

acetate kinase( domain architecture ID 10011301)

acetate kinase catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

CATH:  3.30.420.40
EC:  2.7.2.1
Gene Ontology:  GO:0008776|GO:0016310|GO:0000287|GO:0006085|GO:0005524
PubMed:  16678422

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 1-400 0e+00

acetate kinase A/propionate kinase 2; Reviewed


:

Pssm-ID: 234680  Cd Length: 402  Bit Score: 727.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   1 MKILVINCGSSSLKYQLIDMDNEELLAKGLVERIGIEGSRVKHETIGKDKKVIEEKLNDHGEALKIVLDSLVDKEYGAID 80
Cdd:PRK00180   1 MKILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLGLIK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  81 SLDEIGAVGHRVVHGGEDFAESVIIDDKVMDAINRNIDLAPLHNPPNIIGIEACKKILPNVKQVAVFDTAFHQTMPALNY 160
Cdd:PRK00180  81 DLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 161 IYALPYEEYENHKIRRYGFHGTSHKYITERAASMLGKNVDEVNLITCHLGNGASITAVKGGKSYDTSMGLTPLEGLPMGT 240
Cdd:PRK00180 161 LYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 241 RTGNMDPAIVGFIMDKDNLSIDEINNLMNKESGVLGISGVSSDFRDIEEAAEKGNNRAQLALDIFENSVRKFIGSYLtef 320
Cdd:PRK00180 241 RSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYA--- 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 321 ASLD-EVDGIVFTAGLGENSKTTRANIINGLSVFGIKIDEKAND--IRGEEKVISAEDSKIKVFVIPTNEELMIARDTLK 397
Cdd:PRK00180 318 AALNgRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLaaRFGKEGDISTPDSKVKVLVIPTNEELMIARDTLR 397


                 ...
gi 681104565 398 LVK 400
Cdd:PRK00180 398 LLG 400
 
Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 1-400 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 727.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   1 MKILVINCGSSSLKYQLIDMDNEELLAKGLVERIGIEGSRVKHETIGKDKKVIEEKLNDHGEALKIVLDSLVDKEYGAID 80
Cdd:PRK00180   1 MKILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLGLIK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  81 SLDEIGAVGHRVVHGGEDFAESVIIDDKVMDAINRNIDLAPLHNPPNIIGIEACKKILPNVKQVAVFDTAFHQTMPALNY 160
Cdd:PRK00180  81 DLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 161 IYALPYEEYENHKIRRYGFHGTSHKYITERAASMLGKNVDEVNLITCHLGNGASITAVKGGKSYDTSMGLTPLEGLPMGT 240
Cdd:PRK00180 161 LYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 241 RTGNMDPAIVGFIMDKDNLSIDEINNLMNKESGVLGISGVSSDFRDIEEAAEKGNNRAQLALDIFENSVRKFIGSYLtef 320
Cdd:PRK00180 241 RSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYA--- 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 321 ASLD-EVDGIVFTAGLGENSKTTRANIINGLSVFGIKIDEKAND--IRGEEKVISAEDSKIKVFVIPTNEELMIARDTLK 397
Cdd:PRK00180 318 AALNgRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLaaRFGKEGDISTPDSKVKVLVIPTNEELMIARDTLR 397


                 ...
gi 681104565 398 LVK 400
Cdd:PRK00180 398 LLG 400
AckA COG0282
Acetate kinase [Energy production and conversion];
1-400 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 724.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   1 MKILVINCGSSSLKYQLIDMDNEELLAKGLVERIGIEGSRVKHETIGKDKKVIEEKLNDHGEALKIVLDSLVDKEYgaID 80
Cdd:COG0282    1 MKILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGI--IK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  81 SLDEIGAVGHRVVHGGEDFAESVIIDDKVMDAINRNIDLAPLHNPPNIIGIEACKKILPNVKQVAVFDTAFHQTMPALNY 160
Cdd:COG0282   79 DLDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 161 IYALPYEEYENHKIRRYGFHGTSHKYITERAASMLGKNVDEVNLITCHLGNGASITAVKGGKSYDTSMGLTPLEGLPMGT 240
Cdd:COG0282  159 LYALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGT 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 241 RTGNMDPAIVGFIMDKDNLSIDEINNLMNKESGVLGISGVSSDFRDIEEAAEKGNNRAQLALDIFENSVRKFIGSYLtef 320
Cdd:COG0282  239 RSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYA--- 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 321 ASLDEVDGIVFTAGLGENSKTTRANIINGLSVFGIKIDEKANDIRGEEKVISAEDSKIKVFVIPTNEELMIARDTLKLVK 400
Cdd:COG0282  316 AALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVISTPDSRVKVLVIPTNEELMIARDTLRLLK 395
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 3-398 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 670.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   3 ILVINCGSSSLKYQLIDMDNEELLAKGLVERIGIEGSRVKHETIGKDKKVIEEKLNDHGEALKIVLDSLVDKEYGAidSL 82
Cdd:cd24010    1 ILVINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELGV--SL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  83 DEIGAVGHRVVHGGEDFAESVIIDDKVMDAINRNIDLAPLHNPPNIIGIEACKKILPNVKQVAVFDTAFHQTMPALNYIY 162
Cdd:cd24010   79 DEIDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 163 ALPYEEYENHKIRRYGFHGTSHKYITERAASMLGKNVDEVNLITCHLGNGASITAVKGGKSYDTSMGLTPLEGLPMGTRT 242
Cdd:cd24010  159 ALPYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 243 GNMDPAIVGFIMDKDNLSIDEINNLMNKESGVLGISGVSSDFRDIEEAAEKGNNRAQLALDIFENSVRKFIGSYLtefAS 322
Cdd:cd24010  239 GDIDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYA---AA 315

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 681104565 323 LDEVDGIVFTAGLGENSKTTRANIINGLSVFGIKIDEKANDIR-GEEKVISAEDSKIKVFVIPTNEELMIARDTLKL 398
Cdd:cd24010  316 LGGVDAIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAgGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 2-393 0e+00

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 550.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565    2 KILVINCGSSSLKYQLIDMDNEELLAKGLVERIGIEGSRVKHETIGKDKKVIEEKLNDHGEALKIVLDSLvdKEYGAIDS 81
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTL--LKHKIIEL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   82 LDEIGAVGHRVVHGGEDFAESVIIDDKVMDAINRNIDLAPLHNPPNIIGIEACKKILPNVKQVAVFDTAFHQTMPALNYI 161
Cdd:pfam00871  79 LAEITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  162 YALPYEEYENHKIRRYGFHGTSHKYITERAASMLGKNVDEVNLITCHLGNGASITAVKGGKSYDTSMGLTPLEGLPMGTR 241
Cdd:pfam00871 159 YALPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTR 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  242 TGNMDPAIVGFIMDKDNLSIDEINNLMNKESGVLGISGVSSDFRDIEEAAEKGNNRAQLALDIFENSVRKFIGSYLtefA 321
Cdd:pfam00871 239 SGDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYA---A 315

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 681104565  322 SLDEVDGIVFTAGLGENSKTTRANIINGLSVFGIKIDEKANDIRGEEKVISAEDSKIKVFVIPTNEELMIAR 393
Cdd:pfam00871 316 SLERLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNRFGKSGVISTEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-400 0e+00

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 541.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565    1 MKILVINCGSSSLKYQLIDMDN-EELLAKGLVERIGIEGSRVKHETIGKDKKVIEEKLNDHGEALKIVLDSLvdKEYGAI 79
Cdd:TIGR00016   4 MKILVLNAGSSSLKFALFDAVNgEEVLASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTL--LKDKII 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   80 DSLDEIGAVGHRVVHGGEDFAESVIIDDKVMDAINRNIDLAPLHNPPNIIGIEACK--KILPNVKQVAVFDTAFHQTMPA 157
Cdd:TIGR00016  82 KLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALklFPLPKAKNVAVFDTAFHQTMPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  158 LNYIYALPYEEYENHKIRRYGFHGTSHKYITERAASMLGKNVDEVNLITCHLGNGASITAVKGGKSYDTSMGLTPLEGLP 237
Cdd:TIGR00016 162 EAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLM 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  238 MGTRTGNMDPAIVGFIMDKDNLSIDEINNLMNKESGVLGISGVSSDFRDIEEAAEKGNNRAQLALDIFENSVRKFIGSYL 317
Cdd:TIGR00016 242 MGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSYI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  318 tefASLD-EVDGIVFTAGLGENSKTTRANIINGLSVFGIKIDEKANDI--RGEEKVISAEDSKIKVFVIPTNEELMIARD 394
Cdd:TIGR00016 322 ---ASLEgNLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAarSGKSGVISTPESKVKILVIPTNEELMIAQD 398


                  ....*.
gi 681104565  395 TLKLVK 400
Cdd:TIGR00016 399 AIRLTK 404
 
Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 1-400 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 727.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   1 MKILVINCGSSSLKYQLIDMDNEELLAKGLVERIGIEGSRVKHETIGKDKKVIEEKLNDHGEALKIVLDSLVDKEYGAID 80
Cdd:PRK00180   1 MKILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLGLIK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  81 SLDEIGAVGHRVVHGGEDFAESVIIDDKVMDAINRNIDLAPLHNPPNIIGIEACKKILPNVKQVAVFDTAFHQTMPALNY 160
Cdd:PRK00180  81 DLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 161 IYALPYEEYENHKIRRYGFHGTSHKYITERAASMLGKNVDEVNLITCHLGNGASITAVKGGKSYDTSMGLTPLEGLPMGT 240
Cdd:PRK00180 161 LYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 241 RTGNMDPAIVGFIMDKDNLSIDEINNLMNKESGVLGISGVSSDFRDIEEAAEKGNNRAQLALDIFENSVRKFIGSYLtef 320
Cdd:PRK00180 241 RSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYA--- 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 321 ASLD-EVDGIVFTAGLGENSKTTRANIINGLSVFGIKIDEKAND--IRGEEKVISAEDSKIKVFVIPTNEELMIARDTLK 397
Cdd:PRK00180 318 AALNgRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLaaRFGKEGDISTPDSKVKVLVIPTNEELMIARDTLR 397


                 ...
gi 681104565 398 LVK 400
Cdd:PRK00180 398 LLG 400
AckA COG0282
Acetate kinase [Energy production and conversion];
1-400 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 724.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   1 MKILVINCGSSSLKYQLIDMDNEELLAKGLVERIGIEGSRVKHETIGKDKKVIEEKLNDHGEALKIVLDSLVDKEYgaID 80
Cdd:COG0282    1 MKILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGI--IK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  81 SLDEIGAVGHRVVHGGEDFAESVIIDDKVMDAINRNIDLAPLHNPPNIIGIEACKKILPNVKQVAVFDTAFHQTMPALNY 160
Cdd:COG0282   79 DLDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 161 IYALPYEEYENHKIRRYGFHGTSHKYITERAASMLGKNVDEVNLITCHLGNGASITAVKGGKSYDTSMGLTPLEGLPMGT 240
Cdd:COG0282  159 LYALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGT 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 241 RTGNMDPAIVGFIMDKDNLSIDEINNLMNKESGVLGISGVSSDFRDIEEAAEKGNNRAQLALDIFENSVRKFIGSYLtef 320
Cdd:COG0282  239 RSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYA--- 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 321 ASLDEVDGIVFTAGLGENSKTTRANIINGLSVFGIKIDEKANDIRGEEKVISAEDSKIKVFVIPTNEELMIARDTLKLVK 400
Cdd:COG0282  316 AALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVISTPDSRVKVLVIPTNEELMIARDTLRLLK 395
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 3-398 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 670.76  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   3 ILVINCGSSSLKYQLIDMDNEELLAKGLVERIGIEGSRVKHETIGKDKKVIEEKLNDHGEALKIVLDSLVDKEYGAidSL 82
Cdd:cd24010    1 ILVINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELGV--SL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  83 DEIGAVGHRVVHGGEDFAESVIIDDKVMDAINRNIDLAPLHNPPNIIGIEACKKILPNVKQVAVFDTAFHQTMPALNYIY 162
Cdd:cd24010   79 DEIDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 163 ALPYEEYENHKIRRYGFHGTSHKYITERAASMLGKNVDEVNLITCHLGNGASITAVKGGKSYDTSMGLTPLEGLPMGTRT 242
Cdd:cd24010  159 ALPYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 243 GNMDPAIVGFIMDKDNLSIDEINNLMNKESGVLGISGVSSDFRDIEEAAEKGNNRAQLALDIFENSVRKFIGSYLtefAS 322
Cdd:cd24010  239 GDIDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYA---AA 315

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 681104565 323 LDEVDGIVFTAGLGENSKTTRANIINGLSVFGIKIDEKANDIR-GEEKVISAEDSKIKVFVIPTNEELMIARDTLKL 398
Cdd:cd24010  316 LGGVDAIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAgGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 2-393 0e+00

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 550.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565    2 KILVINCGSSSLKYQLIDMDNEELLAKGLVERIGIEGSRVKHETIGKDKKVIEEKLNDHGEALKIVLDSLvdKEYGAIDS 81
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTL--LKHKIIEL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   82 LDEIGAVGHRVVHGGEDFAESVIIDDKVMDAINRNIDLAPLHNPPNIIGIEACKKILPNVKQVAVFDTAFHQTMPALNYI 161
Cdd:pfam00871  79 LAEITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  162 YALPYEEYENHKIRRYGFHGTSHKYITERAASMLGKNVDEVNLITCHLGNGASITAVKGGKSYDTSMGLTPLEGLPMGTR 241
Cdd:pfam00871 159 YALPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTR 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  242 TGNMDPAIVGFIMDKDNLSIDEINNLMNKESGVLGISGVSSDFRDIEEAAEKGNNRAQLALDIFENSVRKFIGSYLtefA 321
Cdd:pfam00871 239 SGDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYA---A 315

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 681104565  322 SLDEVDGIVFTAGLGENSKTTRANIINGLSVFGIKIDEKANDIRGEEKVISAEDSKIKVFVIPTNEELMIAR 393
Cdd:pfam00871 316 SLERLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNRFGKSGVISTEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-400 0e+00

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 541.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565    1 MKILVINCGSSSLKYQLIDMDN-EELLAKGLVERIGIEGSRVKHETIGKDKKVIEEKLNDHGEALKIVLDSLvdKEYGAI 79
Cdd:TIGR00016   4 MKILVLNAGSSSLKFALFDAVNgEEVLASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTL--LKDKII 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   80 DSLDEIGAVGHRVVHGGEDFAESVIIDDKVMDAINRNIDLAPLHNPPNIIGIEACK--KILPNVKQVAVFDTAFHQTMPA 157
Cdd:TIGR00016  82 KLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALklFPLPKAKNVAVFDTAFHQTMPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  158 LNYIYALPYEEYENHKIRRYGFHGTSHKYITERAASMLGKNVDEVNLITCHLGNGASITAVKGGKSYDTSMGLTPLEGLP 237
Cdd:TIGR00016 162 EAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLM 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  238 MGTRTGNMDPAIVGFIMDKDNLSIDEINNLMNKESGVLGISGVSSDFRDIEEAAEKGNNRAQLALDIFENSVRKFIGSYL 317
Cdd:TIGR00016 242 MGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSYI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  318 tefASLD-EVDGIVFTAGLGENSKTTRANIINGLSVFGIKIDEKANDI--RGEEKVISAEDSKIKVFVIPTNEELMIARD 394
Cdd:TIGR00016 322 ---ASLEgNLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAarSGKSGVISTPESKVKILVIPTNEELMIAQD 398


                  ....*.
gi 681104565  395 TLKLVK 400
Cdd:TIGR00016 399 AIRLTK 404
PRK12397 PRK12397
acetate/propionate family kinase;
2-398 1.20e-159

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 455.07  E-value: 1.20e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   2 KILVINCGSSSLKYQLIDMDNEELLAKGLVERIGIEGSRVKHETiGKDKKVIEEKLNDHGEALKIVLDSLVDkeYGAIDS 81
Cdd:PRK12397   4 KIMAINAGSSSLKFQLLEMPQGDMLCQGLIERIGMADAQVTIKT-HSQKWQETVPVADHRDAVTLLLEKLLG--YQIINS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  82 LDEIGAVGHRVVHGGEDFAESVIIDDKVMDAINRNIDLAPLHNPPNIIGIEACKKILPNVKQVAVFDTAFHQTMPALNYI 161
Cdd:PRK12397  81 LRDIDGVGHRVAHGGEFFKDSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQTLDEPAYI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 162 YALPYEEYENHKIRRYGFHGTSHKYITERAASMLGKNVDEVNLITCHLGNGASITAVKGGKSYDTSMGLTPLEGLPMGTR 241
Cdd:PRK12397 161 YPLPWRYYAELGIRRYGFHGTSHKYVSGVLAEKLGVPLSALRVICCHLGNGSSICAIKNGRSVNTSMGFTPQSGVMMGTR 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 242 TGNMDPAIVGFIMDKDNLSIDEINNLMNKESGVLGISGVSSDFRDIEEAAEKGNNRAQLALDIFENSVRKFIGSYLTEFA 321
Cdd:PRK12397 241 SGDIDPSILPWIAQREGKTPQQLNQLLNNESGLLGVSGVSSDYRDVEQAANTGNRQAKLALTLFAERIRATIGSYIMQMG 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 681104565 322 SLdevDGIVFTAGLGENSKTTRANIINGLSVFGIKIDEKANdiRGEEKVISAEDSKIKVFVIPTNEELMIARDTLKL 398
Cdd:PRK12397 321 GL---DALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKN--QRNATFIQTENALVKVAVINTNEELMIAQDVMRI 392
PRK12379 PRK12379
propionate kinase;
3-400 4.35e-148

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 425.30  E-value: 4.35e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   3 ILVINCGSSSLKYQLIDMDNEELLAKGLVERIGIEGSRVkheTIGKDKKVieeKLNDHG--EALKIVLDSLvDKEygaiD 80
Cdd:PRK12379   7 VLVINCGSSSIKFSVLDASDCEVLMSGIADGINSENAFL---SVNGGEPA---PLAHHSyeGALKAIAFEL-EKR----N 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  81 SLDEIGAVGHRVVHGGEDFAESVIIDDKVMDAINRNIDLAPLHNPPNIIGIEACKKILPNVKQVAVFDTAFHQTMPALNY 160
Cdd:PRK12379  76 LNDSVALIGHRIAHGGSIFTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFDTSFHQTLAPEAY 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 161 IYALPYEEYENHKIRRYGFHGTSHKYITERAASMLGKNVDEVNLITCHLGNGASITAVKGGKSYDTSMGLTPLEGLPMGT 240
Cdd:PRK12379 156 LYGLPWEYYEELGVRRYGFHGTSHRYVSQRAHSLLNLDEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMGT 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 241 RTGNMDPAIVGFIMDKDNLSIDEINNLMNKESGVLGISGVSSDFRDIEEAAEKGNNRAQLALDIFENSVRKFIGSYLtef 320
Cdd:PRK12379 236 RSGDVDFGAMAWIASQTGQTLGDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERAQLAIKTFVHRIARHIAGHA--- 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 321 ASLDEVDGIVFTAGLGENSKTTRANIINGLSVFGIKIDEKANDI--RGEEKVISAEDSKIKVFVIPTNEELMIARDTLKL 398
Cdd:PRK12379 313 ASLHRLDGIIFTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNQpnSGGERIISSENSRVICAVIPTNEEKMIALDAIHL 392


                 ..
gi 681104565 399 VK 400
Cdd:PRK12379 393 GK 394
PRK07157 PRK07157
acetate kinase; Provisional
 1-398 1.06e-143

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 414.14  E-value: 1.06e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   1 MKILVINCGSSSLKYQLIDMDNEELLAKGLVERIGIEGSRVKHEtIGKDKKVIEEKLNDHGEALKIVLDslVDKEYGAID 80
Cdd:PRK07157   3 AKILVINAGSSSIKWQLFDKENLNLIASGLAERIGLENGLIKIK-FGKKKYEKEVDMPNHKVAVAVLIE--IWEENKLIE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  81 SLDEIGAVGHRVVHGGEDFAESVIIDDKVMDAINRNIDLAPLHNPPNIIGIEACKKILPNVKQVAVFDTAFHQTMPALNY 160
Cdd:PRK07157  80 DLEEIELIGFRVVHGGDYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFHTSIPKINY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 161 IYALPYEEYENHKIRRYGFHGTSHKYITERAASMLGKnvDEVNLITCHLGNGASITAVKGGKSYDTSMGLTPLEGLPMGT 240
Cdd:PRK07157 160 TYPINYEIAKKYGIKKYGFHGISHKFITNKVEKILNK--DKVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAGVMMGT 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 241 RTGNMDPAIVGFIMDKDNLSIDEINNLMNKESGVLGISGVSSDFRDIEEAAEKGNNRAQLALDIFENSVRKFIGSYLTEF 320
Cdd:PRK07157 238 RSGDIDPSIHEFVAKEANMSISEFTDLLNKKSGLLGVSGISSDLRDVIKAAESGNKRAKFALDLYAQKIVDYLANYINKI 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 321 ASldEVDGIVFTAGLGENSKTTRANIINGLSVFGIKIDEKANDIR----GEEKVISAEDSKIKVFVIPTNEELMIARDTL 396
Cdd:PRK07157 318 GK--KIDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNLKKigeyGPIELISTPDSDIPVYVIRTNEELLIAKNAI 395


                 ..
gi 681104565 397 KL 398
Cdd:PRK07157 396 KL 397
PRK12440 PRK12440
acetate/propionate family kinase;
3-399 1.99e-127

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 372.66  E-value: 1.99e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   3 ILVINCGSSSLKYQLIDMDNEELLAKGLVERIGIEGSRVKHETIGKDKkviEEKLNDHGEALKIVLDSLVdkeyGAIDSL 82
Cdd:PRK12440   6 VLVINSGSSSLKFAVIDSVTGEAVLSGLGECFGLEDARMSWKYQGEKT---EIAIEGEDNHHKIAIGRLV----GLTEEL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  83 ---DEIGAVGHRVVHGGEDFAESVIIDDKVMDAINRNIDLAPLHNPPNIIGIEACKKILPNVKQVAVFDTAFHQTMPALN 159
Cdd:PRK12440  79 gftQDIVAVGHRIVHGGEKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFHQTMPKKA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 160 YIYALPYEEYENHKIRRYGFHGTSHKYITERAASMLGKNVDEVNLITCHLGNGASITAVKGGKSYDTSMGLTPLEGLPMG 239
Cdd:PRK12440 159 FTGAIAKELYTDFGIRRYGFHGTSHYFVSREAAKMLNKPIEESSFISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLMMG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 240 TRTGNMDPAIVGFIMDKdNLSIDEINNLMNKESGVLGISGVSSDFRDIEEAAEKGNNRAQLALDIFENSVRKFIGSYLte 319
Cdd:PRK12440 239 TRCGDLDPGIIEFLLKK-GWSQEKVFNSLNKKSGFLGVSGLTSDARGILEAMEEGHEGATLAFEVFTYRVAKYIASYL-- 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 320 fASLDEVDGIVFTAGLGENSKTTRANIINGLSVFGIKIDEKAN-DIR-GEEKVIS-AEDSKIKVFVIPTNEELMIARDTL 396
Cdd:PRK12440 316 -AALDSLDGIIFTGGIGENSLPIRREILKNLKLLGFVEDEKGNeDARfGKAGIIAkSELLNAVAMVIPTNEEFVIAQQSV 394


                 ...
gi 681104565 397 KLV 399
Cdd:PRK12440 395 ELL 397
PRK07058 PRK07058
acetate/propionate family kinase;
3-398 4.37e-102

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 308.13  E-value: 4.37e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   3 ILVINCGSSSLKYQLIDMDNEEL--LAKGLverIGIEGSRVK-HETIGKDKKVIEEKlNDHGEALKIVLDSLVDKeYGAI 79
Cdd:PRK07058   6 LLTFNAGSSTVKIGLFEVDGNEArrIGKGD---IDFRRAPLRfHLRNGGETLDIPLK-ASVTDDLHTVLDETFDW-LAAH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  80 DSLDEIGAVGHRVVHGGEDFAESVIIDDKVMDAINRNIDLAPLHNPPNIIGIEACKKILPNVKQVAVFDTAFHQTMPALN 159
Cdd:PRK07058  81 FDVSELVAVGHRVVHGGDRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASFDTAFHRTQPDLV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 160 YIYALPYEEYEnHKIRRYGFHGTSHKYI----TERAASMLGKNVdevnlITCHLGNGASITAVKGGKSYDTSMGLTPLEG 235
Cdd:PRK07058 161 RRFAIPRALHD-EGIKRYGFHGLSYKFVagelRRRAPELARGKV-----VAAHLGSGASLCALDAGKSRDTSMGFSTLDG 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 236 LPMGTRTGNMDPAIVGFIMDKDNLSIDEINNLMNKESGVLGISGVSSDFRDIEEAAEKGnnrAQLALDIFENSVRKFIGS 315
Cdd:PRK07058 235 IPMATRCGALDPGVVLHLLKQEGMSLDEVEDLLYHRSGLLGVSGISGDTRDLLASDAPE---AREALDLFALRIAGEIAR 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 316 YLTefaSLDEVDGIVFTAGLGENSKTTRANIINGLSVFGIKIDEKANDIRGEekVISAEDSKIKVFVIPTNEELMIARDT 395
Cdd:PRK07058 312 LAA---TLGGLDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANAANAF--TISSRTSRVAAFVIPTDEEQVIADEA 386


                 ...
gi 681104565 396 LKL 398
Cdd:PRK07058 387 FSV 389
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 2-335 8.20e-26

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 106.85  E-value: 8.20e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   2 KILVINCGSSSLKYQLIDmDNEELLAKGLverigiegsRVKHETIGKDKKVIEEklndHGEALKIVLDSLVDKEYgaidS 81
Cdd:cd24011    1 RILVINPGSTSTKIAVFE-GEEEVFEETI---------EHSPEELAKFPSIIDQ----LEFRKEAVLDFLKENGI----D 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  82 LDEIGAVGHRV-----VHGGedfaeSVIIDDKVMDAINRnidlAPLHNPPN----IIGIEACKKIlpNVKQVAVfDTAFH 152
Cdd:cd24011   63 LSDLDAIVGRGgllkpIPGG-----TYRVNEAMLEDLLS----GPLGEHASnlgaPIAYELAKEY--GIPAYIV-DPVVV 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 153 QTMPALNYIYALPyeEYEnhkiRRYGFHGTSHKYITERAASMLGKNVDEVNLITCHLGNGASITAVKGGKSYDTSMGLtP 232
Cdd:cd24011  131 DEMDPVARITGIP--EIE----RRSIFHALNQKAVARRAAKELGKPYEELNLIVAHLGGGISVGAHRKGRVIDVNNAL-D 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 233 LEGlPMGT-RTGNMDpaIVGFI--MDKDNLSIDEINNLMNKESGVLGISGVsSDFRDIEEAAEKGNNRAQLALDIFENSV 309
Cdd:cd24011  204 GEG-PFSPeRAGTLP--VGDLIklCFSGKYTLEELKKKLKGKGGLVAYLGT-NDFREVEKRIEAGDEKAKLVLDAMAYQI 279

                        330       340
                 ....*....|....*....|....*.
gi 681104565 310 RKFIGSYLTEFAslDEVDGIVFTAGL 335
Cdd:cd24011  280 AKEIGALAAVLK--GKVDAIILTGGL 303
PRK03011 PRK03011
butyrate kinase; Provisional
 1-335 3.23e-18

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 85.21  E-value: 3.23e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565   1 MKILVINCGSSSLKYQLIDmDNEELLAKGLverigiegsRVKHETIGKDKKVIEEKlndhgEA-LKIVLDSLVDKEYgAI 79
Cdd:PRK03011   2 MRILVINPGSTSTKIAVFE-DEKPIFEETL---------RHSAEELEKFKTIIDQY-----EFrKQAILDFLKEHGI-DL 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565  80 DSLDEIgaVGH----RVVHGGedfaeSVIIDDKVMDAINRNI--------------DLAPLHNPPNIIgieackkilpnV 141
Cdd:PRK03011  66 SELDAV--VGRggllKPIPGG-----TYRVNEAMLEDLKNGKygehasnlgaiiayEIAKELGIPAFI-----------V 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 142 KQVAVfDTafhqtMPALNYIYALPyeEYEnhkiRRYGFHGTSHKYITERAASMLGKNVDEVNLITCHLGNGASITAVKGG 221
Cdd:PRK03011 128 DPVVV-DE-----MEPVARISGLP--EIE----RKSIFHALNQKAVARRVAKELGKKYEELNLIVAHLGGGISVGAHRKG 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 681104565 222 KSYDTSMGLtPLEGlPMGT-RTGNMdPAivgfiMDKDNL------SIDEINNLMNKESGVLGISGvSSDFRDIEEAAEKG 294
Cdd:PRK03011 196 RVIDVNNAL-DGEG-PFSPeRAGGL-PV-----GDLVELcfsgkyTKEELKKKLVGKGGLVAYLG-TNDAREVEKRIEEG 266

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 681104565 295 NNRAQLALDIFENSVRKFIGSYLtefASLD-EVDGIVFTAGL 335
Cdd:PRK03011 267 DEKAKLVYEAMAYQIAKEIGAMA---AVLKgKVDAIVLTGGL 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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