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Conserved domains on  [gi|597568092|emb|CDM17690|]
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Uncharacterized MFS-type transporter yttB [Listeria monocytogenes R479a]

Protein Classification

MDR family MFS transporter( domain architecture ID 13023665)

MDR (multi-drug resistance) family major facilitator superfamily (MFS) transporter confers resistance to specific drugs/toxins through their active efflux from the cell

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26758938|26098515|27052334|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 11-391 3.91e-69

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 222.87  E-value: 3.91e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  11 IVIIGMVLLYTGLSFIWPFNMIYMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLSTASL 90
Cdd:cd17329    3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  91 CFFHGFPFFIWNLWAVGIAMGMVFSGLYAAAGLTHPTGGRT-GFNAIYVAQNIGVAVGPLLAGLLAKQGMshvyigSFVF 169
Cdd:cd17329   83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTrAFSLLYWAINLGVAIGPLLGGLLLLYSF------RLLF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 170 AIAFAGYFFFFFHKIDWKSERVSAETKHRKKGAKREFPTKLALCSFILLLLTYLLCQLPHVQWQSNLSTYMTEIKGVTSS 249
Cdd:cd17329  157 LAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 250 EYGNLWSLNGALIVLGQLVLIPVVNRFKkyLLVQIYIGIFLFILSFVVAMNASVYSGFVLGMIFLTLGEMFAWPAIPTIA 329
Cdd:cd17329  237 LLGLLLALNALLIVLLQFPVARLVERFR--LRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLV 314

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 597568092 330 YQLAPKGAAGLYQGLVNGMATAARMLAPFIGAIVVQNLGGIKALFIGAFILLGCALISITLQ 391
Cdd:cd17329  315 AALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
 
Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 11-391 3.91e-69

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 222.87  E-value: 3.91e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  11 IVIIGMVLLYTGLSFIWPFNMIYMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLSTASL 90
Cdd:cd17329    3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  91 CFFHGFPFFIWNLWAVGIAMGMVFSGLYAAAGLTHPTGGRT-GFNAIYVAQNIGVAVGPLLAGLLAKQGMshvyigSFVF 169
Cdd:cd17329   83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTrAFSLLYWAINLGVAIGPLLGGLLLLYSF------RLLF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 170 AIAFAGYFFFFFHKIDWKSERVSAETKHRKKGAKREFPTKLALCSFILLLLTYLLCQLPHVQWQSNLSTYMTEIKGVTSS 249
Cdd:cd17329  157 LAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 250 EYGNLWSLNGALIVLGQLVLIPVVNRFKkyLLVQIYIGIFLFILSFVVAMNASVYSGFVLGMIFLTLGEMFAWPAIPTIA 329
Cdd:cd17329  237 LLGLLLALNALLIVLLQFPVARLVERFR--LRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLV 314

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 597568092 330 YQLAPKGAAGLYQGLVNGMATAARMLAPFIGAIVVQNLGGIKALFIGAFILLGCALISITLQ 391
Cdd:cd17329  315 AALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
9-352 8.09e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 78.09  E-value: 8.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092   9 LCIVIIGMVLLYTGLSFIWPFnMIYMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLSTA 88
Cdd:COG2814   12 LLALALGAFLSGLGIGIVLPA-LPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  89 SLCFFHGFPFFIWNLWAVGIAMGMVFSGLYAAAGLTHPTGGRTGFNAIY-VAQNIGVAVGPLLAGLLAKQ-GMSHVYIGS 166
Cdd:COG2814   91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLgAGLGLGPALGPLLGGLLADLfGWRWVFLVN 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 167 FVFAIAFAGYFFFffhkidwkseRVSAETKHRKKGAKREFPTKLALCSFILLLLTYLLCQLPHVQWQSNLSTYMTEIKGV 246
Cdd:COG2814  171 AVLALLALLLLLR----------LLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 247 TSSEYGNLWSLNGALIVLGQLVLIPVVNRFKKYLLvqIYIGIFLFILSFVVAMNASVYSGFVLGMIFLTLGEMFAWPAIP 326
Cdd:COG2814  241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL--LLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQ 318

                        330       340
                 ....*....|....*....|....*.
gi 597568092 327 TIAYQLAPKGAAGLYQGLVNGMATAA 352
Cdd:COG2814  319 ALVAELAPPEARGRASGLYNSAFFLG 344
MFS_1 pfam07690
Major Facilitator Superfamily;
12-357 1.39e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 74.38  E-value: 1.39e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092   12 VIIGMVLLYTGLSFIWPFNMIYMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLSTASLC 91
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092   92 FFHGFPFFIWNLWAVGIAMGMVFSGLYAAAGLTHPTGGRTGFNAIYVA-QNIGVAVGPLLAGLLAKQ-GMSHVYIGSFVF 169
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAgFGLGAALGPLLGGLLASLfGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  170 AIAFAGYFFFFFHKIDWKSERVSAETKHRKKGAKREFPTKLALCSFILLLLTYLLCQLPhvqwqSNLSTYMTEIKGVTSS 249
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGL-----LTYLPLYQEVLGLSAL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  250 EYGNLWSLNGALIVLGQLVLIPVVNRFKKY-LLVQIYIGIFLFILSFVVAMNASVYSGFVLGMIFLTLGEMFAWPAIPTI 328
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRrRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315

                         330       340
                  ....*....|....*....|....*....
gi 597568092  329 AYQLAPKGAAGLYQGLVNGMATAARMLAP 357
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 11-391 3.91e-69

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 222.87  E-value: 3.91e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  11 IVIIGMVLLYTGLSFIWPFNMIYMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLSTASL 90
Cdd:cd17329    3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  91 CFFHGFPFFIWNLWAVGIAMGMVFSGLYAAAGLTHPTGGRT-GFNAIYVAQNIGVAVGPLLAGLLAKQGMshvyigSFVF 169
Cdd:cd17329   83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTrAFSLLYWAINLGVAIGPLLGGLLLLYSF------RLLF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 170 AIAFAGYFFFFFHKIDWKSERVSAETKHRKKGAKREFPTKLALCSFILLLLTYLLCQLPHVQWQSNLSTYMTEIKGVTSS 249
Cdd:cd17329  157 LAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 250 EYGNLWSLNGALIVLGQLVLIPVVNRFKkyLLVQIYIGIFLFILSFVVAMNASVYSGFVLGMIFLTLGEMFAWPAIPTIA 329
Cdd:cd17329  237 LLGLLLALNALLIVLLQFPVARLVERFR--LRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLV 314

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 597568092 330 YQLAPKGAAGLYQGLVNGMATAARMLAPFIGAIVVQNLGGIKALFIGAFILLGCALISITLQ 391
Cdd:cd17329  315 AALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
9-352 8.09e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 78.09  E-value: 8.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092   9 LCIVIIGMVLLYTGLSFIWPFnMIYMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLSTA 88
Cdd:COG2814   12 LLALALGAFLSGLGIGIVLPA-LPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  89 SLCFFHGFPFFIWNLWAVGIAMGMVFSGLYAAAGLTHPTGGRTGFNAIY-VAQNIGVAVGPLLAGLLAKQ-GMSHVYIGS 166
Cdd:COG2814   91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLgAGLGLGPALGPLLGGLLADLfGWRWVFLVN 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 167 FVFAIAFAGYFFFffhkidwkseRVSAETKHRKKGAKREFPTKLALCSFILLLLTYLLCQLPHVQWQSNLSTYMTEIKGV 246
Cdd:COG2814  171 AVLALLALLLLLR----------LLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 247 TSSEYGNLWSLNGALIVLGQLVLIPVVNRFKKYLLvqIYIGIFLFILSFVVAMNASVYSGFVLGMIFLTLGEMFAWPAIP 326
Cdd:COG2814  241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL--LLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQ 318

                        330       340
                 ....*....|....*....|....*.
gi 597568092 327 TIAYQLAPKGAAGLYQGLVNGMATAA 352
Cdd:COG2814  319 ALVAELAPPEARGRASGLYNSAFFLG 344
MFS_1 pfam07690
Major Facilitator Superfamily;
12-357 1.39e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 74.38  E-value: 1.39e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092   12 VIIGMVLLYTGLSFIWPFNMIYMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLSTASLC 91
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092   92 FFHGFPFFIWNLWAVGIAMGMVFSGLYAAAGLTHPTGGRTGFNAIYVA-QNIGVAVGPLLAGLLAKQ-GMSHVYIGSFVF 169
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAgFGLGAALGPLLGGLLASLfGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  170 AIAFAGYFFFFFHKIDWKSERVSAETKHRKKGAKREFPTKLALCSFILLLLTYLLCQLPhvqwqSNLSTYMTEIKGVTSS 249
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGL-----LTYLPLYQEVLGLSAL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  250 EYGNLWSLNGALIVLGQLVLIPVVNRFKKY-LLVQIYIGIFLFILSFVVAMNASVYSGFVLGMIFLTLGEMFAWPAIPTI 328
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRrRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315

                         330       340
                  ....*....|....*....|....*....
gi 597568092  329 AYQLAPKGAAGLYQGLVNGMATAARMLAP 357
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 12-388 1.31e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 68.76  E-value: 1.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  12 VIIGMVLLYTGLSFIWPFNMIYMtQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLSTASLC 91
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  92 FFHGFPFFIWNLWAVGIAMGMVFSGLYAAAGLTHPTGGRTGFNAIY-VAQNIGVAVGPLLAGLLAKQ-GMSHVYIGSFVF 169
Cdd:cd17325   80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFsSAIGLGFLIGPLLGGLLADAlGYRAPFLVCAAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 170 AIAFAGYFFFFFHK--IDWKSERVSAETKHRKKGAKREFPTKLALCSFILLLLTYLLCQLPhvqwqsNLSTYMTEIKGVT 247
Cdd:cd17325  160 ALLALVLALLLLPEprPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEP------FLPLYAAELGGLS 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 248 SSEYGNLWSLNGALIVLGQLVLIPVVNRFKKYLLvqIYIGIFLFILSFVVAMNASVYSGFVLGMIFLTLGEMFAWPAIPT 327
Cdd:cd17325  234 PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPL--ILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLA 311

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 597568092 328 IAYQLAPKGAAGLYQGLVNGMATAARMLAPFIGAIVVQNLGGIKALFIGAFILLGCALISI 388
Cdd:cd17325  312 LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
9-390 1.23e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 65.66  E-value: 1.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092   9 LCIVIIGMVLLYTGLSFIWPFNMIYMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLSTA 88
Cdd:COG2271   11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  89 SLCFFHGFPFFIWNLWAVGIAMGMVFSGLYAAAGLTHPTGGRTGFNAIY-VAQNIGVAVGPLLAGLLAKQ-GMSHVYIGS 166
Cdd:COG2271   91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFnAGGPLGGALAPPLLGWLLAAfGWRAAFLIL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 167 FVFAIAfagyfffffhkidwkservsaetkhrkkgakrefptkLALCSFILLLLTYLLCQLPHVQWQSNLSTYMTEIKGV 246
Cdd:COG2271  171 GLPGLL-------------------------------------LALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGL 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 247 TSSEYGNLWSLNGALIVLGQLVLIPVVNRFKKYLLVQIYIGIFLFILSFVVAMNASVYSGFVLGMIFLTLGEMFAWPAIP 326
Cdd:COG2271  214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 597568092 327 TIAYQLAPKGAAGLYQGLVNGMATAARMLAPFIGAIVVQNLGGIKALFIGAFILLGCALISITL 390
Cdd:COG2271  294 ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 25-386 2.48e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 64.76  E-value: 2.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  25 FIWPFNMIYMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLSTASLCFFHGFPFFIWNLW 104
Cdd:cd06174   13 GLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRF 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 105 AVGIAMGMVFSGLYAAAGLTHPTGGRTGFNAIY-VAQNIGVAVGPLLAGLLAKQGMSHV-YIGSFVFAIAFAGYFFFFFH 182
Cdd:cd06174   93 LLGLGSGLIDPAVLALIADLFPERERGRALGLLqAFGSVGGILGPLLGGILASSLGFGWrAVFLIAAALALLAAILLLLV 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 183 KIDWKSERVSAETKHRKKGAKREFPTKLALCSFILLLLTYLLCQLPHVQWQSNLSTYMTEIKGVTSSEYGNLWSLNGALI 262
Cdd:cd06174  173 VPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAG 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 263 VLGQLVLIPVVNRFKKyLLVQIYIGIFLFILSFVVAMNASVYSGFVLGMIFLTLGEMFAWPAIPTIAYQLAPKGAAGLYQ 342
Cdd:cd06174  253 ALGSLLLGLLSDRLIG-RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAF 331

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 597568092 343 GLVNGMATAARMLAPFIGAIVVQNLGGIKALFIGAFILLGCALI 386
Cdd:cd06174  332 GLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
11-397 1.75e-10

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 62.18  E-value: 1.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  11 IVIIGMVLLYTGLSF-IWPFNMIYMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLSTAS 89
Cdd:COG0738   10 LIAIYLLFFLWGFATaLWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  90 LCFFHGFPFFIWNLWAVGIAMGMVFSGLYAAAGLTHPTGGRTGFNAIYVAQNIGVAVGPLLAGLLAKQGMSHVYIGSFVF 169
Cdd:COG0738   90 FALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLI 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 170 AIAFAGYFFFFFHKIDW-KSERVSAETKHRKKGAKREFPTKLALCSFILLLLTYLLCQLPhvqwQSNLSTYMTEIKGVTS 248
Cdd:COG0738  170 LAVLLLLLALLFLRSKLpEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAI----GDWLPLYLKDVLGLSE 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 249 SEYGNLWSLNGALIVLGQLVLIPVVNRFKKYLLVQIYIGifLFILSFVVAMNASVYSGFVLGMIFLTLGEMFAWPAIPTI 328
Cdd:COG0738  246 ATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSAL--LAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSL 323

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 597568092 329 AYQLAPKGAAGLYqGLVNGMATAARMLAPFIGAIVVQNLGGIKALFIGAFILLGCALISITLQQILQKK 397
Cdd:COG0738  324 ALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 5-155 2.19e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 58.74  E-value: 2.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092   5 LPKDLCIVIIGMVLLYTGLSFIWPFNMIYMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILV 84
Cdd:cd17325  197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 597568092  85 LSTASLCFFHGFPFFIWNLWAVGIAMGMVFSGLYAAAGLTHPTGGR-TGFNAIYVAQNIGVAVGPLLAGLLA 155
Cdd:cd17325  277 VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRgTAMGLFNTAFSLGMVLGPLLGGFLY 348
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 233-392 2.92e-07

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 51.84  E-value: 2.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 233 QSNLSTYMTEIKGVTSSEYGNLWSLNGALIVLGQLVLIPVVNRFKK-YLLVQIYIGIFLFILSFVVAMNASVYSgFVLGM 311
Cdd:cd17390  192 RSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNnEYLLLLHSFILLALSLLGLALAPSIWL-LVLCL 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 312 IFLTLGEMFAWPAIPTIAYQLAPKGAAGLYQGLVNGMATAARMLAPFIGAIVVQnLGGIKALFIGAFILLGCALISITLQ 391
Cdd:cd17390  271 TPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQE-FSVSGPGLLGAVLALAAILLMLARQ 349


                 .
gi 597568092 392 Q 392
Cdd:cd17390  350 R 350
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 33-388 4.75e-07

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 51.40  E-value: 4.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  33 YMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLSTASLCFFHGFPFFIwnlwaVGIAMGM 112
Cdd:cd17478   21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLL-----LLVALAG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 113 VFSGLY---AAAGLTHPTGGRTGF-NAIY-VAQNIGVAVGPLLAGLLAkqgMSHVYIGSFVFAIAFAGYFFFFFHKIDWK 187
Cdd:cd17478   96 IGSAAFhpeGARLASQAAGGRRGLaMSIFsVGGNLGFALGPLIAAALV---ALFGGLGLLILLIIPGLAVALLLLRLRPL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 188 SERvsaETKHRKKGAKREFPTKLALCSFILLLLTYLLCQLPHVQWQSNLSTYMTEiKGVTSSEYGNLWSLNGALIVLGQL 267
Cdd:cd17478  173 KKP---EAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 268 VLIPVVNRF-KKYLLVQIYIGIFLFILSFVVAMNASVYSGFVLGMIFLtlgeMFAWPAIPTIAYQLAPKG---AAGLYQG 343
Cdd:cd17478  249 IGGPLSDRFgRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLL----FASFPVTVVLAQELLPGNvglASGLMMG 324

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 597568092 344 LVNGMATaarMLAPFIGAIvVQNLGGIKALFIGAFILLGCALISI 388
Cdd:cd17478  325 LSFGLGG---IGAPVLGAL-ADAFGLESVLLILALLPLLGALLAF 365
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
7-146 3.87e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 48.43  E-value: 3.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092   7 KDLCIVIIGMVLLYTGLSFIWPFNMIYMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLS 86
Cdd:COG2814  207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 597568092  87 TASLCFFHGFPFFIWNLWAVGIAMGMVFSGLYAAAGLTHPTGGRTGFNAIY-VAQNIGVAV 146
Cdd:COG2814  287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYnSAFFLGGPL 347
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
9-386 5.44e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 48.34  E-value: 5.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092   9 LCIVIIGMVLLYtGLSFIWPFNMIYMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLSTA 88
Cdd:COG2223    7 LLLATLAFFLAF-GVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  89 SLCFFHGFPFFIWNLWAVGIAMGMVFSGLYAAAGLTHPTGGRTGFNAIYVA-QNIGVAVGPLLAGLLAKQ-GMSHVYIGS 166
Cdd:COG2223   86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGgGNLGAAVAAFLAPLLIAAfGWRNAFLIL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 167 FVFAIAFAGYFFFFFHKIDWKSERVSAETKHRKKGAKREFPT-KLALCSFILLLLTYLlcqlphvqWQSNLSTYMTEIKG 245
Cdd:COG2223  166 GILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFwLLSLLYFGTFGSFIG--------FSSWLPPYLVDQFG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 246 VTSSEYGNLWSLNGALIVLGQLVLIPVVNRF-KKYLLVQIYIGIFLFILSFVVAMNASVYSGFVLGMIFLTLGEMFAwpA 324
Cdd:COG2223  238 LSAATAGLLAALFALLGALGRPLGGWLSDRIgGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNG--A 315

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 597568092 325 IPTIAYQLAPKGAAGLYQGLVNGMATAARMLAPFIGAIVVQNLGGIKALFIGAFILLGCALI 386
Cdd:COG2223  316 VFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALV 377
MFS_1 pfam07690
Major Facilitator Superfamily;
236-386 8.62e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.41  E-value: 8.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  236 LSTYMTEIKGVTSSEYGNLWSLNGALIVLGQLVLIPVVNRFKKYLLvqIYIGIFLFILSFVVAMNASVYSGFVLGMIFLT 315
Cdd:pfam07690  19 LPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRV--LLIGLLLFALGLLLLLFASSLWLLLVLRVLQG 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 597568092  316 LGEMFAWPAIPTIAYQLAPKGAAGLYQGLVNGMATAARMLAPFIGAIVVQNLGGIKALFIGAFILLGCALI 386
Cdd:pfam07690  97 LGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL 167
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
245-388 9.85e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 47.28  E-value: 9.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 245 GVTSSEYGNLWSLNGALIVLGQLVLIPVVNRF-KKYLLVqiyIGIFLFILSFVVAMNASVYSGFVLGMIFLTLGEMFAWP 323
Cdd:COG2814   41 GASPAQAGLVVTAYLLGAALGAPLAGRLADRFgRRRVLL---LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFP 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 597568092 324 AIPTIAYQLAPKGAAGLYQGLVNGMATAARMLAPFIGAIVVQNLGGIKALFIGAFILLGCALISI 388
Cdd:COG2814  118 AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLL 182
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 186-391 3.02e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 45.64  E-value: 3.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 186 WKSERVSAETKHRKKGAKREFPTKLALCSFILLLLTYLLCQLPHVQwqsnLSTYMTEIKGVTSSEYGNLWSLNGALIVLG 265
Cdd:cd17473  174 PEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQ----LPFLLQERGGGSAALIGLALAIASLAGAIG 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 266 QLVLIPVVNRFKKYLLvqIYIGIFLFILSFVVAMNASVYSGFVLGMIFLTLGEMFAWPAIPTIAYQLAPKGAAGLYQGLV 345
Cdd:cd17473  250 ALLFGRLKRRLGKRRL--LAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIV 327

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 597568092 346 NGMATAARMLAPFIGAIVVQNLGGIKALF-IGAFILLGCALISITLQ 391
Cdd:cd17473  328 TSAFFLGQFLSPLVLGPLVNLTGGLSGAFlILGVLALVLAIVLLLLR 374
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 9-166 3.18e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 45.64  E-value: 3.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092   9 LCIVIIGMVLLytGLSFIWPfnmIYMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLSTA 88
Cdd:cd17503  185 LLSFLLGLGLF--GAMFLLP---LYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTL 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  89 SLCFFH---GFPFFIWNLWAVGIAMGMVFSGLYAAAGLTHPTGGRTGFNAIY-VAQNIGVAVGPLLAGLLAKQGMSHVYI 164
Cdd:cd17503  260 LLAFLTpdtSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFnTIRQLGGSIGTALLATLLTNRTQFHHS 339


                 ..
gi 597568092 165 GS 166
Cdd:cd17503  340 RL 341
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 233-390 5.27e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 44.88  E-value: 5.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 233 QSNLSTYMTEIKGVTSSEYGNLWSLNGALIVLGQLVLIPVVNRfKKYLLVQIYIGIFLFILSFVVAMNASVYSGFVLGMI 312
Cdd:cd17330  194 ESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAK-RLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAA 272

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 597568092 313 FLTLGEMFAWPAIPTIAYQLAPKGAAGLYQGLVNGMATAARMLAPFIGAIVVQNLGGikalfiGAFILLGCALISITL 390
Cdd:cd17330  273 ILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGP------GVPFLLAAGLLLIAL 344
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 69-162 3.24e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 42.56  E-value: 3.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  69 RFSGFISLTIGTIILVLSTASLCFFHGFPFFIWNLWAVGIAMGMVFSGLYAAAGLTHPTGGRTGFNAIY-VAQNIGVAVG 147
Cdd:cd17474  261 RFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYnFVRFLGQAVG 340

                         90
                 ....*....|....*
gi 597568092 148 PLLAGLLAKQGMSHV 162
Cdd:cd17474  341 PLLFGLLLEIFGLSA 355
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 41-386 5.03e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 41.92  E-value: 5.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092  41 STTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLSTASLCFFHGFPFFIWNLWAVGIAMGMVFSGLYAA 120
Cdd:cd17333   29 NVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTF 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 121 AGLTHPTGGRTGFNAIYVAQNIGVAVGPLLAGLLAKQGMSHVYigSFVFAIAFAGYFFFFFHKIDWKSERVSAETKHRKK 200
Cdd:cd17333  109 VGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSW--AYLIIGLIYLLLAILILLTLFPELPSARNPQQSVG 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 201 GAKREFPTKLALCSFILLLLTYLLCQLPHVQWQSNLSTYMTEIKGVTSSEYGNLWSLNGALIVLGQLVLIPVVNRFKKYL 280
Cdd:cd17333  187 AFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHT 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 281 LVQIYIGIfLFILSFVVAMNASVYSGFVLGMI-FLTLGEMFawPAIPTIAYQLAPKgAAGLYQGLVNGMATAARMLAPFI 359
Cdd:cd17333  267 LLVLSGSG-ALLGLLILLLAPTLVVGLVATALlGLFMAALF--PTILSLGISNLPY-AKGKGTSVLLAAGSIGGAIIPFI 342

                        330       340
                 ....*....|....*....|....*..
gi 597568092 360 GAIVVQNLGgiKALFIGAFILLGCALI 386
Cdd:cd17333  343 MGFIAEAVG--IQTAMLLITILYAIIF 367
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
6-154 7.45e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.43  E-value: 7.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092   6 PKDLCIVIIGMVLLYTGLSFIWPFNMIYMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVL 85
Cdd:COG2211  227 NRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 597568092  86 STASLCFFHGFPFFIWNLWAV--GIAMGMVFSGLYAA-AGLTHPTGGRTG-------FNAIYVAQNIGVAVGPLLAGLL 154
Cdd:COG2211  307 GLLLLFFLGPGNLWLLLVLAAlaGIGLGAILVLPWAMlADVVDYDEWKTGrrreglyFGIFTFAIKLGQALAGALAGLL 385
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 236-388 1.14e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 40.66  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092 236 LSTYMTEIKGVTSSEYGNLWSLNGALIVLGQLVLIPVVNRF-KKYLLVQIYIGIFLFILSFVVAMNASVYSGFVLGMIFL 314
Cdd:cd17316  200 LPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIgRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILS 279

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 597568092 315 TLGeMFAWPAIPTIAYQLAPKGAAGLYQGLVNGMATAARMLAPFIGAIVVQNLGGIKALFIGAFILLGCALISI 388
Cdd:cd17316  280 FFV-GGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
MFS_1 pfam07690
Major Facilitator Superfamily;
11-148 7.90e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.17  E-value: 7.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597568092   11 IVIIGMVLLYTGLSFIWPFNMIYMTQELGMSTTDASLVLLINSGVGIVSSIIGGIIFDRFSGFISLTIGTIILVLSTASL 90
Cdd:pfam07690 203 LWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGL 282

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 597568092   91 CFFHGFPFFIWNLWA---VGIAMGMVFSGLYAAAGLTHPTGGRTGFNAIY-VAQNIGVAVGP 148
Cdd:pfam07690 283 LLLSLTLSSLWLLLAlllLGFGFGLVFPALNALVSDLAPKEERGTASGLYnTAGSLGGALGP 344
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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