|
Name |
Accession |
Description |
Interval |
E-value |
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
5-392 |
0e+00 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 599.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 5 YGFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFA 84
Cdd:COG0626 1 MGPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALAARFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 85 SGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAII 164
Cdd:COG0626 81 SGMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 165 DIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKFDYMCeFGGVM 244
Cdd:COG0626 161 DIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNA-LGAVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 245 SPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGLKAAKR 324
Cdd:COG0626 240 SPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGGREAARR 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 432179922 325 FINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNALK 392
Cdd:COG0626 320 FLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALA 387
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
23-392 |
0e+00 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 538.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 23 NALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASGMAAISSVLFSLLSPKD 102
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEAADLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 103 NVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDIQQIVRIAKTYGVKVVV 182
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 183 DNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKFDYMcEFGGVMSPFNAWLMLRGLKTLGLR 262
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRL-ALGTILSPFDAWLLLRGLKTLPLR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 263 MRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGLKAAKRFINSVKLAKIAVSLGDCE 342
Cdd:cd00614 240 MERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGVE 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 432179922 343 TLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNALK 392
Cdd:cd00614 320 SLVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
8-392 |
3.12e-179 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 503.30 E-value: 3.12e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 8 DTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKdaedimnfEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASGM 87
Cdd:pfam01053 1 DTLAVHAGQRPDPQTGAVSVPIYLTSTYVFDFAG--------EEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGM 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 88 AAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDIQ 167
Cdd:pfam01053 73 AAITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 168 QIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKFdYMCEFGGVMSPF 247
Cdd:pfam01053 153 AIAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYF-LQNATGAVLSPF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 248 NAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGLKAAKRFIN 327
Cdd:pfam01053 232 DAWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKFLD 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 432179922 328 SVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNALK 392
Cdd:pfam01053 312 NLKLFSLAVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
3-392 |
3.95e-166 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 471.82 E-value: 3.95e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 3 KDYGFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVA 82
Cdd:COG2873 4 KKYGFETLALHAGQEPDPTTGARAVPIYQTTSYVFDDAEHAADLFALKEPGNIYTRIMNPTTDVLEKRIAALEGGVAALA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 83 FASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLA 162
Cdd:COG2873 84 TASGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNPALD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 163 IIDIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSK------------------ 224
Cdd:COG2873 164 VLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVDGgnfdwaangkfpeltepd 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 225 -------------DADYIKKLKFDYMCEFGGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGL 291
Cdd:COG2873 244 psyhglvyteafgNAAFITKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNYPGL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 292 ADFRGHELAKRQM-DGFGAVMSFEVKGGLKAAKRFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSI 370
Cdd:COG2873 324 PSHPYHELAQKYLpKGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGVTPDL 403
|
410 420
....*....|....*....|..
gi 432179922 371 VRLSVGIENVKDIIEDLDNALK 392
Cdd:COG2873 404 IRLSVGIEDIDDIIADLDQALA 425
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
3-391 |
3.68e-157 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 448.12 E-value: 3.68e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 3 KDYGFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVA 82
Cdd:PRK06234 5 KKMGFATKAIHGGHIGDKQFGSLATPIYQTSTFIFDSAEQGGRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 83 FASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLA 162
Cdd:PRK06234 85 AASGMGAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 163 IIDIQQIVRIAKTY--GVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKdADYIKKLKFDYMCEF 240
Cdd:PRK06234 165 VTDIKAISNIAHENnkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGK-EEFINQVKLFGIKDM 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 241 -GGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGL 319
Cdd:PRK06234 244 tGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFELKGGV 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 432179922 320 KAAKRFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNAL 391
Cdd:PRK06234 324 EEGKVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQAL 395
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
1-392 |
7.68e-154 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 440.01 E-value: 7.68e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 1 MGKDYGFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDA 80
Cdd:PRK07503 4 SHNNTGFSTRAIHHGYDPLDHGGALVPPVYLTATFAFPTAEYGAECFAGEEEGHFYSRISNPTLALLEQRMASLEGGEAA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 81 VAFASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPN 160
Cdd:PRK07503 84 VALASGMGAITATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 161 LAIIDIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADyIKKLKFDYMCEF 240
Cdd:PRK07503 164 MRLVDIAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKAL-ADRIRLEGLKDM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 241 -GGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGL 319
Cdd:PRK07503 243 tGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFELKGGI 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 432179922 320 KAAKRFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNALK 392
Cdd:PRK07503 323 AAGRRFMNALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALD 395
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
4-391 |
1.20e-152 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 436.24 E-value: 1.20e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 4 DYGFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAF 83
Cdd:TIGR01328 1 RMTFATRAIHAGYPPKDQFGALTPPIYQTSTFVFDSCEQGGNRFAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 84 ASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAI 163
Cdd:TIGR01328 81 SSGMGAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 164 IDIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSkDADYIKKLKFDYMCEFGG- 242
Cdd:TIGR01328 161 IDMERVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICG-KAELLQQIRMVGIKDMTGs 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 243 VMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGLKAA 322
Cdd:TIGR01328 240 VISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFELKGGFAGA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 432179922 323 KRFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNAL 391
Cdd:TIGR01328 320 KKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQAL 388
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
3-392 |
2.49e-150 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 430.42 E-value: 2.49e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 3 KDYGFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVA 82
Cdd:PRK06767 2 KKKHMETALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 83 FASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLA 162
Cdd:PRK06767 82 FGSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 163 IIDIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDaDYIKKLKFDYMCEFGG 242
Cdd:PRK06767 162 LIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKT-RALAEKIRPMRKDIGG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 243 VMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPgladfrGHELAKRQMDGFGAVMSFEVKGGLKAA 322
Cdd:PRK06767 241 IMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYP------EGELASRQMKRGGGVISFSIKGGKEET 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 323 KRFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNALK 392
Cdd:PRK06767 315 QAFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALK 384
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
1-391 |
5.71e-149 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 426.75 E-value: 5.71e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 1 MGKDYGFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAedimnfeKQGFIYTRGNNPTLQLFEKRMAALEEGEDA 80
Cdd:PRK07811 7 HHANQGFATRAIHAGYEPDPATGAVNPPIYASSTFAQDGVGGL-------RGGYEYARTGNPTRTALEEQLAALEGGAYG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 81 VAFASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPN 160
Cdd:PRK07811 80 RAFSSGMAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 161 LAIIDIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKFdYMCEF 240
Cdd:PRK07811 160 LSITDIAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAF-LQNGA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 241 GGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGLK 320
Cdd:PRK07811 239 GAVPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEE 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 432179922 321 AAKRFINSVKLAKIAVSLGDCETLIELPAAMTHAgypKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNAL 391
Cdd:PRK07811 319 AARDFCARTKVFTLAESLGGVESLIEHPSAMTHA---STAGSQLEVPDDLVRLSVGIEDVADLLADLEQAL 386
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
1-392 |
2.93e-142 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 409.78 E-value: 2.93e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 1 MGKDYGFDTLSIHGGAEKNhPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDA 80
Cdd:PRK08133 1 DDDSLGFDTLAVRAGQLRS-PFGEHSEALFLTSSFVFESAAEAAARFAGEEPGNIYSRFTNPTVTMFQERLAALEGAEAC 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 81 VAFASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPN 160
Cdd:PRK08133 80 VATASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 161 LAIIDIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGvAVSKDADYIKKLkFDYMCEF 240
Cdd:PRK08133 160 TELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGG-AVVGSKELMEEV-FGFLRTA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 241 GGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGLK 320
Cdd:PRK08133 238 GPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVKGGRE 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 432179922 321 AAKRFINSVKLAKIAVSLGDCETLIELPAAMTHAGY-PKARLQEfDLTDSIVRLSVGIENVKDIIEDLDNALK 392
Cdd:PRK08133 318 AAWRVIDATRLISITANLGDTKTTITHPATTTHGRLsPEARAAA-GITEGLIRVAVGLEDVADIKADLARGLA 389
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
6-392 |
4.10e-138 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 400.58 E-value: 4.10e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 6 GFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFAS 85
Cdd:TIGR01326 1 HFETLQLHAGQEPDPTTGSRAVPIYQTTSYVFDSTEHAAALFGLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 86 GMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIID 165
Cdd:TIGR01326 81 GQAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 166 IQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAV-SKDAD----------------- 227
Cdd:TIGR01326 161 IEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVdGGKFDwnngrfplfttpdpsyh 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 228 ------------YIKKLKFDYMCEFGGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFR 295
Cdd:TIGR01326 241 glvftetlgnpaFILKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASHP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 296 GHELAKRQMD-GFGAVMSFEVKGGLKAAKRFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLS 374
Cdd:TIGR01326 321 HHALAKKYLPkGFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRLS 400
|
410
....*....|....*...
gi 432179922 375 VGIENVKDIIEDLDNALK 392
Cdd:TIGR01326 401 VGIENIDDIIADLEQALE 418
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
1-391 |
1.95e-135 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 392.95 E-value: 1.95e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 1 MGKDYGFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDA 80
Cdd:PRK08249 3 DFNNAGVGTKAVWAGEKEYLPYGATQVPVVLSVAYGYDDIDEWYDVALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 81 VAFASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPN 160
Cdd:PRK08249 83 TAFSTGMAAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPT 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 161 LAIIDIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSkDADYIKKLkFDYMCEF 240
Cdd:PRK08249 163 LKIVDIERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVCG-SKELMEQV-YHYREIN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 241 GGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGLK 320
Cdd:PRK08249 241 GATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFVLKGGMD 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 432179922 321 AAKRFINSVKLAKIAVSLGDCETLIELPAAMTHA-GYPKARLQeFDLTDSIVRLSVGIENVKDIIEDLDNAL 391
Cdd:PRK08249 321 TVKRLLPKLRYAHRAANLGAVETIYGPARTTSHVeNTLEERAA-LGIPEGLVRISVGIEDTEDLIADLEQAF 391
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
8-391 |
5.69e-134 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 388.43 E-value: 5.69e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 8 DTLSIHGGAEKNhPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASGM 87
Cdd:TIGR01325 1 ATLAVRGGMLRS-GFEETAEALYLTSGYVYDSAAVAAKRFAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 88 AAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDIQ 167
Cdd:TIGR01325 80 AAIFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 168 QIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVaVSKDADYIKKLKFDYMCEFGGVMSPF 247
Cdd:TIGR01325 160 AVAELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGA-ILGSEEYMDEPVQKLLRHTGPAMSPF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 248 NAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVkGGLKAAKRFIN 327
Cdd:TIGR01325 239 NAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDL-DCRQAAFKVLD 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 432179922 328 SVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNAL 391
Cdd:TIGR01325 318 AMRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSVGLEDVDDLIADIDRAL 381
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
9-392 |
1.08e-132 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 385.23 E-value: 1.08e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 9 TLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKdaedimnfEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASGMA 88
Cdd:PRK07671 5 TKLIHGGIIGDPSTGAVSVPIYQVSTYKQEAVG--------KHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 89 AISSVlFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDIQQ 168
Cdd:PRK07671 77 AITAV-MMLFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 169 IVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKFdYMCEFGGVMSPFN 248
Cdd:PRK07671 156 ISTIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHF-VQNSTGGILGPQD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 249 AWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVkGGLKAAKRFINS 328
Cdd:PRK07671 235 SWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFDV-GSEETANKVLER 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 432179922 329 VKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNALK 392
Cdd:PRK07671 314 LQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
9-393 |
8.90e-126 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 367.85 E-value: 8.90e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 9 TLSIHGgAEKNHPKNALNPPIFMTStyVFDDVKDAedimNFEKQGFI--YTRGNNPTLQLFEKRMAALEEGEDAVAFASG 86
Cdd:PRK08574 5 TDAVRG-YRGSDPYGSLQPPIYLTA--LFRQEGEA----YPSDRGFDlkYSREENPTLRPLEEALAKLEGGVDALAFNSG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 87 MAAISSVLFSLLSPKDNVVVHKTLYGSSFTVThKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDI 166
Cdd:PRK08574 78 MAAISTLFFSLLKAGDRVVLPMEAYGTTLRLL-KSLEKFGVKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 167 QQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLkFDYMCEFGGVMSP 246
Cdd:PRK08574 157 PEVAKAAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEEL-WEWRRRLGTIMQP 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 247 FNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKR--QMDGFGAVMSFEVKGGLKAAKR 324
Cdd:PRK08574 236 FEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRlfGKDLYGGVVSFRVKGGRDAVLK 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 432179922 325 FINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNALKV 393
Cdd:PRK08574 316 FLRSLKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQALGS 384
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
1-392 |
1.30e-122 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 360.22 E-value: 1.30e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 1 MGKDYGFDTLSIHGGAEKNhPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDA 80
Cdd:PRK07504 5 MARKWRPATRLVHSGTLRS-QFGETSEALFLTQGFVYDTAEAAEARFKGEDPGFIYSRYSNPTVDMFEKRMCALEGAEDA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 81 VAFASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPN 160
Cdd:PRK07504 84 RATASGMAAVTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAVRPNTKVFFLESPTNPT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 161 LAIIDIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSkDADYIKKLKFDYMCEF 240
Cdd:PRK07504 164 LEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLS-DKAWIEEHLQDYFRHT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 241 GGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGLK 320
Cdd:PRK07504 243 GPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQADIIAKQMTGGSTLVAFELKGGKE 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 432179922 321 AAKRFINSVKLAKIAVSLGDCETLIELPAAMTHAGY-PKARLqEFDLTDSIVRLSVGIENVKDIIEDLDNALK 392
Cdd:PRK07504 323 AAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLsPEARA-ELGISEGFLRLSAGLEDTDDLIEDLAAALK 394
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
1-392 |
2.15e-121 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 356.77 E-value: 2.15e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 1 MGKDYGFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKdaedimNFEKqgFIYTRGNNPTLQLFEKRMAALEEGEDA 80
Cdd:PRK08064 1 MAMSYSIDTLLLHNQYKHDKQTGAVNVPIYHASTFHQFDFD------TFGK--YDYSRSGNPTREALEDIIAELEGGTKG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 81 VAFASGMAAISSVLFsLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPN 160
Cdd:PRK08064 73 FAFASGMAAISTAFL-LLSKGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 161 LAIIDIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKFdYMCEF 240
Cdd:PRK08064 152 LKVTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYF-LQNSF 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 241 GGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVkGGLK 320
Cdd:PRK08064 231 GAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTL-QSEE 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 432179922 321 AAKRFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNALK 392
Cdd:PRK08064 310 AVRQFVSHVKLPVFAVSLGAVESILSYPAKMSHAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALS 381
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
7-391 |
2.12e-119 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 351.51 E-value: 2.12e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 7 FDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKdaedimnfEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASG 86
Cdd:PRK06176 3 MQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIG--------RPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 87 MAAISSVlFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDI 166
Cdd:PRK06176 75 LAGIHAV-FSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 167 QQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKFdYMCEFGGVMSP 246
Cdd:PRK06176 154 AQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAF-FQNAIGGVLGP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 247 FNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGlKAAKRFI 326
Cdd:PRK06176 233 QDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKND-SEAVAFV 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 432179922 327 NSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNAL 391
Cdd:PRK06176 312 ESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAF 376
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
3-393 |
2.61e-117 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 347.88 E-value: 2.61e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 3 KDYGFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVA 82
Cdd:PRK08134 5 SPPGFDTLALHAGAAPDPATGARAVPIHLTTSFVFRDSDHAAALFNLERAGHVYSRISNPTVAVLEERVAALEGGVGAIA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 83 FASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLA 162
Cdd:PRK08134 85 TASGQAALHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 163 IIDIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDA-DYIKKLKFDYMCE-- 239
Cdd:PRK08134 165 VLDIPTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGRfDWEASGKFPELTEpy 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 240 ----------------------------FGGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGL 291
Cdd:PRK08134 245 agfhgmvfaeestvaafllrarreglrdFGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPEL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 292 ADFRGHELAKRQM-DGFGAVMSFEVKGGLKAAKRFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSI 370
Cdd:PRK08134 325 ESHPDHALAKRLLpRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGT 404
|
410 420
....*....|....*....|...
gi 432179922 371 VRLSVGIENVKDIIEDLDNALKV 393
Cdd:PRK08134 405 IRLSIGLEDADDLIDDLKRALKA 427
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
1-388 |
5.93e-114 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 339.42 E-value: 5.93e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 1 MGKDYGFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDA 80
Cdd:PRK07812 8 PTANWSFETKQIHAGQTPDPATNARALPIYQTTSYTFDDTDHAAALFGLAEPGNIYTRIMNPTQDVVEQRIAALEGGVAA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 81 VAFASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDcksVDFTE-PKAVE---GAIDKNTKVLYFETP 156
Cdd:PRK07812 88 LLLASGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIE---VSFVEdPDDLDawrAAVRPNTKAFFAETI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 157 ANPNLAIIDIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSK------------ 224
Cdd:PRK07812 165 SNPQIDVLDIPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVDGgtfdwtqgrfpg 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 225 -----------------DADYIKKLKFDYMCEFGGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVF 287
Cdd:PRK07812 245 fttpdpsyhgvvfaelgPPAYALKARVQLLRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVN 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 288 YPGLADFRGHELAKRQM-DGFGAVMSFEVKGGLKAAKRFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDL 366
Cdd:PRK07812 325 YAGLPSSPWYERAKRLApKGTGAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGV 404
|
410 420
....*....|....*....|..
gi 432179922 367 TDSIVRLSVGIENVKDIIEDLD 388
Cdd:PRK07812 405 TPGLVRLAVGIEGIDDILADLE 426
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
5-392 |
5.17e-113 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 336.82 E-value: 5.17e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 5 YGFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFA 84
Cdd:PRK08248 7 FRLETLAIHAGQEIDPTTGSRAVPIYQTTSYGFRDSEHAANLFSLKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALAVS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 85 SGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAII 164
Cdd:PRK08248 87 SGQAAITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 165 DIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVS------KDAD----------- 227
Cdd:PRK08248 167 DIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVDsgkfdwKGSGkfpgltepdps 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 228 --------------YIKKLKFDYMCEFGGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLAD 293
Cdd:PRK08248 247 yhglvytdavgeaaYITKARVQLLRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPS 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 294 FRGHELAKRQM-DGFGAVMSFEVKGGLKAAKRFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVR 372
Cdd:PRK08248 327 HPSYELAKKYLpKGQGAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGLVR 406
|
410 420
....*....|....*....|
gi 432179922 373 LSVGIENVKDIIEDLDNALK 392
Cdd:PRK08248 407 LSVGTEAIDDILDDLRQAIR 426
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
24-392 |
2.85e-111 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 330.13 E-value: 2.85e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 24 ALNPPIFMTSTYVFDDVKdaedimnfEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASGMAAISsVLFSLLSPKDN 103
Cdd:PRK08247 22 TVNPPVYFSTAYRHEGIG--------ESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQ-LVMSLFRSGDE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 104 VVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDIQQIVRIAKTYGVKVVVD 183
Cdd:PRK08247 93 LIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIAKKHGLLLIVD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 184 NTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLkFDYMCEFGGVMSPFNAWLMLRGLKTLGLRM 263
Cdd:PRK08247 173 NTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERL-AYYQNAAGAVLSPFDSWLLIRGMKTLALRM 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 264 RQHEANAMAIAEFLKSHDSIEEVFYPGLadfrghelakrqmdgfGAVMSFEVKGGlKAAKRFINSVKLAKIAVSLGDCET 343
Cdd:PRK08247 252 RQHEENAKAIAAFLNEQPGVTDVLYPGR----------------GGMLSFRLQDE-EWVNPFLKSLKLITFAESLGGVES 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 432179922 344 LIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNALK 392
Cdd:PRK08247 315 FITYPATQTHADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFK 363
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
6-391 |
9.73e-111 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 330.91 E-value: 9.73e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 6 GFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFAS 85
Cdd:PRK05994 7 GFATLAVHAGAQPDPTTGARATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRITNPTNAVLEERVAALEGGTAALAVAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 86 GMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIID 165
Cdd:PRK05994 87 GHAAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTVTD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 166 IQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAV-------SKDADY---------- 228
Cdd:PRK05994 167 IAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVdggtfdwSKSGKYpmlseprpey 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 229 --------IKKLKFDYMC------EFGGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADF 294
Cdd:PRK05994 247 hglvlhetFGNFAFAIAArvlglrDLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPDD 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 295 RGHELAKRQM-DGFGAVMSFEVKGGLKAAKRFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRL 373
Cdd:PRK05994 327 PYHALAQKYSpKGAGAVFTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVRL 406
|
410
....*....|....*...
gi 432179922 374 SVGIENVKDIIEDLDNAL 391
Cdd:PRK05994 407 SIGIEDVDDIIADLEQAL 424
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
8-392 |
2.84e-110 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 329.00 E-value: 2.84e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 8 DTLSIHGGAEK-NHPKNAlnPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASG 86
Cdd:PRK07810 17 ATIGVRGGLLRsGFEETA--EALYLTSGYVYESAAAAEAAFTGELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATASG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 87 MAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDI 166
Cdd:PRK07810 95 MSAVFTALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVDI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 167 QQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGvAVSKDADYI----KKLkfdyMCEFGG 242
Cdd:PRK07810 175 AAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGG-AILGDREYIdgpvQKL----MRHTGP 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 243 VMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGLKAA 322
Cdd:PRK07810 250 ALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFELDAPEDAA 329
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 432179922 323 KR----FINSVKLAKIAVSLGDCETLIELPAAMTH-AGYPKARlQEFDLTDSIVRLSVGIENVKDIIEDLDNALK 392
Cdd:PRK07810 330 KKrafeVLDKLRVIDISNNLGDAKSLITHPATTTHrAMGPEGR-AAIGLGDGVVRLSVGLEDTDDLIADLDRALG 403
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
18-392 |
6.02e-110 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 327.17 E-value: 6.02e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 18 KNHPKNALNPPIFMTSTYVFDDvkdaedimNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASGMAAISsVLFSL 97
Cdd:TIGR01329 11 KNDPYDASSMPIYQTATFKQPL--------AIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALD-VITRL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 98 LSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDIQQIVRIAKTYG 177
Cdd:TIGR01329 82 LNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHAQN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 178 VKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKFDYMCEfGGVMSPFNAWLMLRGLK 257
Cdd:TIGR01329 162 ALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNST-GSGLAPFDCWLLLRGIK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 258 TLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVkGGLKAAKRFINSVKLAKIAVS 337
Cdd:TIGR01329 241 TLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKGAGSVLSFET-GSVALSKRLVEATKLFSITVS 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 432179922 338 LGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNALK 392
Cdd:TIGR01329 320 FGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFV 374
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
5-391 |
7.58e-109 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 326.24 E-value: 7.58e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 5 YGFD-TLSihggaeknhpKNALNPPIFMTSTYVFDDVKDAEDIMNF----------EKQGFIYTRGNNPTLQLFEKRMAA 73
Cdd:PRK07049 25 YGYDpELS----------EGAVKPPVFLTSTFVFRSAEDGRDFFDYvsgrkeppagEGAGLVYSRFNHPNSEIVEDRLAV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 74 LEEGEDAVAFASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIdcKSVDF---TEPKAVEGAIDK---- 146
Cdd:PRK07049 95 YEGAESAALFSSGMSAIATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGV--GAVGFadgLSEAAIGAAAEAaaak 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 147 -NTKVLYFETPANPNLAIIDIQQIVRIAKTYGVK------VVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGG 219
Cdd:PRK07049 173 gRVSLILIETPANPTNSLVDVAAVRRVADAIEARqghrpiIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 220 vAVSKDADYIKKLKfDYMCEFGGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGL--ADFRGH 297
Cdd:PRK07049 253 -AVLGRKALIRQVR-ALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFldPDSAYG 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 298 ELAKRQMDGFGAVMSFEVKGGLKAAKRFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGI 377
Cdd:PRK07049 331 AVYKRQCTGAGSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSIGI 410
|
410
....*....|....
gi 432179922 378 ENVKDIIEDLDNAL 391
Cdd:PRK07049 411 EHPDDLIADLAQAL 424
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
9-391 |
1.53e-108 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 324.63 E-value: 1.53e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 9 TLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDaedimnfeKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASGMA 88
Cdd:PRK08776 15 TAAVRAGIDRDTAYGAVTPPIVLSSNFSFDGFGN--------KRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 89 AISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDIQQ 168
Cdd:PRK08776 87 AINLVLNALLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 169 IVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKFdYMCEFGGVMSPFN 248
Cdd:PRK08776 167 VIEAAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVW-WANALGLTGSPFD 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 249 AWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGLKAAKRFINS 328
Cdd:PRK08776 246 AFLTLRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFELEGGEAAVRAFVDG 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 432179922 329 VKLAKIAVSLGDCETLIELPAAMTHAGY-PKARLQEfDLTDSIVRLSVGIENVKDIIEDLDNAL 391
Cdd:PRK08776 326 LRYFTLAESLGGVESLIAHPASMTHAAMtAEARAAA-GISDGLLRLSVGIESAEDLLIDLRAGL 388
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
7-393 |
2.78e-107 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 320.88 E-value: 2.78e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 7 FDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASG 86
Cdd:PRK05968 8 FDLAALITAHDEGNAFDAVVPPIFQTSLFTFDSYDEMEDVYAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 87 MAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIdKNTKVLYFETPANPNLAIIDI 166
Cdd:PRK05968 88 MAAISSTVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLESPTSWVFELQDV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 167 QQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDA--DYIKKLKFDYMcefGGVM 244
Cdd:PRK05968 167 AALAALAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEhiARINAEAYPYL---GAKL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 245 SPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFrghelAKRQMDGFGAVMSFEVKGGLKAAkR 324
Cdd:PRK05968 244 SPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANH-----PPAGLSGTSGLFSFIFREGIDVR-A 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 432179922 325 FINSVKLAKIAVSLGDCETLIeLPA--AMTHAGYPKArLQEFDLTDSIVRLSVGIENVKDIIEDLDNALKV 393
Cdd:PRK05968 318 FADALKLFRLGVSWGGHESLV-VPAevVLQQKAQPNS-AARFGVSPRSVRLHVGLEGTEALWADLEQALAA 386
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
8-391 |
3.35e-103 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 311.84 E-value: 3.35e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 8 DTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASGM 87
Cdd:PRK06084 4 ETLAIHAGYSPDPTTKAVAVPIYQTTSYAFDDTQHGADLFDLKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVASGM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 88 AAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDIQ 167
Cdd:PRK06084 84 AAITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIIDIQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 168 QIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVS---------KD------------- 225
Cdd:PRK06084 164 ALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDsgkfpwaehKErfallntpdpsyh 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 226 ----------ADYIKKLKFDYMCEFGGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFR 295
Cdd:PRK06084 244 gvtyteafgpAAFIGRCRVVPLRNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDHP 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 296 GHELAKRQMDGF-GAVMSFEVKGGLKAAKRFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLS 374
Cdd:PRK06084 324 EHELARRYMGGKpASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVRLS 403
|
410
....*....|....*..
gi 432179922 375 VGIENVKDIIEDLDNAL 391
Cdd:PRK06084 404 IGIEHIDDIIADLAQAL 420
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
24-391 |
2.90e-99 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 299.82 E-value: 2.90e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 24 ALNPPIFMTSTYVFDdvkdaedimnfEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASGMAAISSVLFSLLSPKDN 103
Cdd:PRK06460 18 AITTPIYQTTAYHYP-----------EGEKYRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTALALLKPGNS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 104 VVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDIQQIVRIAKTYGVKVVVD 183
Cdd:PRK06460 87 VLVHRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSILIVD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 184 NTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKdADYIKKLkfDYMCE-FGGVMSPFNAWLMLRGLKTLGLR 262
Cdd:PRK06460 167 ATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGY-GKLLNVI--DQMRRtLGTSLDPHAAYLTLRGIKTLKIR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 263 MRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGLKAAKRFINSVKLAKIAVSLGDCE 342
Cdd:PRK06460 244 MDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFEVNGGQESALKVMKSLKLIIPAQTLGGVN 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 432179922 343 TLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNAL 391
Cdd:PRK06460 324 SVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRAL 372
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
6-391 |
3.75e-99 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 299.90 E-value: 3.75e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 6 GFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFAS 85
Cdd:PRK06434 8 GFNTRAVQSGELRDPRFGNVTTPIFETSTFVYPNSEKEAYMDSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 86 GMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIdckSVDFTEPKAV-EGAID-KNTKVLYFETPANPNLAI 163
Cdd:PRK06434 88 GMGAITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGI---HVDYIDTDRLnSLDFDpSNYDLIYAESITNPTLKV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 164 IDIQQIVRIAKtyGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLkFDYMCEFGGV 243
Cdd:PRK06434 165 PDIKNVSSFCH--ENDVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNL-VERRKTLGSN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 244 MSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLadfrghELAKRQMDGFGAVMSFEVKGGLKAAK 323
Cdd:PRK06434 242 PDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKVLRGFGGMLSFELRSMEDVHK 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 432179922 324 rFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNAL 391
Cdd:PRK06434 316 -FIRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENAL 382
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
9-393 |
1.80e-98 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 298.35 E-value: 1.80e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 9 TLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDimnfekqgFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASGMA 88
Cdd:PRK08861 8 TIAVRTGIESDSQYHAVVPPIYLSTNYGFPAFGEVPK--------YDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 89 AISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDIQQ 168
Cdd:PRK08861 80 ALNLWVSALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 169 IVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKFDYMCeFGGVMSPFN 248
Cdd:PRK08861 160 LCQKAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNC-IGATGTPFD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 249 AWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGLKAAKRFINS 328
Cdd:PRK08861 239 SYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFAGSFEQLKVFVKA 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 432179922 329 VKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNALKV 393
Cdd:PRK08861 319 LALFSLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAFAK 383
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
9-393 |
1.16e-95 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 291.03 E-value: 1.16e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 9 TLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKdaedimnfEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASGMA 88
Cdd:PRK08045 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFN--------EPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 89 AISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDIQQ 168
Cdd:PRK08045 79 AIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 169 IVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKFdYMCEFGGVMSPFN 248
Cdd:PRK08045 159 ICHLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAW-WANNIGVTGGAFD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 249 AWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGLKAAKRFINS 328
Cdd:PRK08045 238 SYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGG 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 432179922 329 VKLAKIAVSLGDCETLIELPAAMTHAGY-PKARLqEFDLTDSIVRLSVGIENVKDIIEDLDNALKV 393
Cdd:PRK08045 318 LSLFTLAESLGGVESLISHAATMTHAGMaPEARA-AAGISETLLRISTGIEDGEDLIADLENGFRA 382
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
18-392 |
4.31e-95 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 292.32 E-value: 4.31e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 18 KNHPKNALNPPIFMTSTYvfddvKDAEDImnfEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASGMAAISSVLfSL 97
Cdd:PLN02509 97 KFDPFDAMSTPLYQTATF-----KQPSAI---ENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVT-HL 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 98 LSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDIQQIVRIAKTYG 177
Cdd:PLN02509 168 IKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQG 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 178 VKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKFDYMCEFGGvMSPFNAWLMLRGLK 257
Cdd:PLN02509 248 ALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSG-LAPFDCWLCLRGIK 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 258 TLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFeVKGGLKAAKRFINSVKLAKIAVS 337
Cdd:PLN02509 327 TMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVS 405
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 432179922 338 LGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNALK 392
Cdd:PLN02509 406 FGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFR 460
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
5-390 |
8.78e-95 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 290.62 E-value: 8.78e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 5 YGFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFA 84
Cdd:PRK05613 12 WGFETRSIHAGQSVDSDTSARNLPIYQTTSYVFDSAEHAKQRFALEDLGPIYSRLTNPTVEALENRIASLEGGVHAVAFA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 85 SGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSV-DFTEPKAVEGAIDKNTKVLYFETPANPNLAI 163
Cdd:PRK05613 92 SGQAAETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANPQADV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 164 IDIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVA---------------------V 222
Cdd:PRK05613 172 LDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLidggkfdwtverdgkpvfpyfV 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 223 SKDADY--IK-----------KLKFDYMCEFGGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYP 289
Cdd:PRK05613 252 TPDPAYhgLKyadlgapafglKARAGLLRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFA 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 290 GLAD---FRGHElaKRQMDGFGAVMSFEVKGGLKAAKRFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDL 366
Cdd:PRK05613 332 GLKDspwYATKE--KLGLKYTGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGI 409
|
410 420
....*....|....*....|....
gi 432179922 367 TDSIVRLSVGIENVKDIIEDLDNA 390
Cdd:PRK05613 410 TQATVRLSVGIEDIDDIIADLEGG 433
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
1-392 |
1.73e-88 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 271.69 E-value: 1.73e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 1 MGKDYGFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKdaedimnfEKQGFIYTRGNNPTLQLFEKRMAALEEGEDA 80
Cdd:PRK07269 1 MSKDLHINTILAQAGIKSDEATGALVTPLHFSTTYQHPEFG--------QSTGFDYTRTKNPTRAKLEETLAAIESADYA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 81 VAFASGMAAISsVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDfTEPKAVEgAIDKNTKVLYFETPANPN 160
Cdd:PRK07269 73 LATSSGMSAIV-LAFSVFPVGSKVVAVRDLYGGSFRWFNQQEKEGRFHFTYAN-TEEELIA-AIEEDTDIVYIETPTNPL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 161 LAIIDIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKFDyMCEF 240
Cdd:PRK07269 150 MVEFDIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYN-LNTT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 241 GGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLadfrghelakrqmdgfGAVMSFEVKGGLK 320
Cdd:PRK07269 229 GAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGK----------------GGMISFKVADETR 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 432179922 321 AAKrFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNALK 392
Cdd:PRK07269 293 IPH-ILNSLKVFTFAESLGGVESLITYPTTQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQALE 363
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
24-392 |
2.56e-88 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 272.72 E-value: 2.56e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 24 ALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASGMAAISSVLFSLLSPKDN 103
Cdd:PRK05939 9 AVHKPIHTSVTYGYEDARDLIDVFQGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGDH 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 104 VVVHKTLYGSsftvTHKL---LPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDIQQIVRIAKTYGVKV 180
Cdd:PRK05939 89 LVSSQFLFGN----TNSLfgtLRGLGVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLY 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 181 VVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKD-----------ADY---------IKKLKFDYMCEF 240
Cdd:PRK05939 165 VVDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTDTGlfdwsaypnifPAYrkgdpqqwgLTQIRKKGLRDM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 241 GGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGLK 320
Cdd:PRK05939 245 GATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELADGID 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 432179922 321 AAKrFINSVKLAKIAVSLGDCETLIeLPAAMT---HAGypKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNALK 392
Cdd:PRK05939 325 CFD-FLNRLKLVIKATHLGDTRTLV-IPVAPTiyyEMG--AERRASMGIADSLIRVSVGIEDEADLIADFEQALD 395
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
4-391 |
1.57e-87 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 269.56 E-value: 1.57e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 4 DYGFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFD-DVKDAEDImnfekqgfiYTRGNNPTLQLFEKRMAALEEGEdAVA 82
Cdd:PRK07582 1 AYGDGTRSVHAGGPEAVPGEPVLPGPVFAAPYHLSpGEPTGPDT---------YGRASNPTWRALEAALGELEGAE-ALV 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 83 FASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSV---DFTEPkAVEGAidkntKVLYFETPANP 159
Cdd:PRK07582 71 FPSGMAAITAVLRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREAptaGMAEA-ALAGA-----DLVLAETPSNP 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 160 NLAIIDIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKfDYMCE 239
Cdd:PRK07582 145 GLDVCDLAALAAAAHAAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELMAAVE-RWRLL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 240 FGGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVkGGL 319
Cdd:PRK07582 224 AGAIPGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFEL-ADA 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 432179922 320 KAAKRFINSVKLAKIAVSLGDCETLIELpaamthagypKARLQEfDLTDSIVRLSVGIENVKDIIEDLDNAL 391
Cdd:PRK07582 303 AAAERFVAASRLVVAATSFGGVHTSADR----------RARWGD-AVPEGFVRLSCGIEDTDDLVADLERAL 363
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
1-391 |
1.06e-82 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 259.22 E-value: 1.06e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 1 MGKDYGFDTLSIHGG-AEKNHPKNALnpPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGED 79
Cdd:PRK06702 1 MGESWGKGTICVQGGyTPKNGEPRVL--PLYQSTTYKYDTSDDLAALFNLEAEGYIYTRIGNPTLAAFEQKLAELEGGVG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 80 AVAFASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCK--SVDFTEPKAVEGAIDKnTKVLYFETPA 157
Cdd:PRK06702 79 AVATASGQAAIMLAVLNICSSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTffNPNLTADEIVALANDK-TKLVYAESLG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 158 NPNLAIIDIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSK------------- 224
Cdd:PRK06702 158 NPAMNVLNFKEFSDAAKELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIDGgnfdwtngkypel 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 225 -----------------DADYIKKLKFDYMCEFGGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVF 287
Cdd:PRK06702 238 vepdpsyhgvsyvqnfgAAAYIVKARVQLLRDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVN 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 288 YPGLADFRGHELAKRQMD-GFGAVMSFEVKGGLKAAKRFINSVKLAKIAVSLGDCETLIELPAAMTHAGYPKARLQEFDL 366
Cdd:PRK06702 318 YPGLDSNENYSLAQKYLKkGASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGV 397
|
410 420
....*....|....*....|....*
gi 432179922 367 TDSIVRLSVGIENVKDIIEDLDNAL 391
Cdd:PRK06702 398 TSDLIRLSVGIEDVSDIIADLEAAL 422
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
54-377 |
3.93e-69 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 223.87 E-value: 3.93e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 54 FIYTRGNNPTLQLFEKRMAALEEGEDAVAFASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLP-KYHIDCKSV 132
Cdd:PLN02242 68 YIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQLCSSGGHVVASNTLYGGTHALLAHFLPrKCNITTTFV 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 133 DFTEPKAVEGAIDKN-TKVLYFETPANPNLAIIDIQQIVRIAKTYGVKVVVDNTFAtPYFQRPLAFGADVVVHSATKYIC 211
Cdd:PLN02242 148 DITDLEAVKKAVVPGkTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNTFA-PMVLSPARLGADVVVHSISKFIS 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 212 GHGDALGGvAVSKDADYIKKLkfdymcefggvMSPFNAWLMLRG--------------LKTLGLRMRQHEANAMAIAEFL 277
Cdd:PLN02242 227 GGADIIAG-AVCGPAELVNSM-----------MDLHHGALMLLGptmnpkvafelserLPHLSLRMKEHCRRAMEYAKRM 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 278 KSHDSieEVFYPGLADFRGHELAKRQMD---GFGAVMSFEVKGGLKAAK---RFINSVKLAKIAVSLGDCETLIELPAAM 351
Cdd:PLN02242 295 KELGL--KVIYPGLEDHPQHALLKSMANkgyGFGGLLCLDMDTEERANRlmrYLQNSTQFGFMAVSLGYYETLMSCSGSS 372
|
330 340
....*....|....*....|....*.
gi 432179922 352 THAGYPKARLQEFDLTDSIVRLSVGI 377
Cdd:PLN02242 373 TSSELDPEEKAAAGISPGLVRMSVGY 398
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
6-391 |
3.26e-68 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 220.76 E-value: 3.26e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 6 GFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAED-IMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFA 84
Cdd:PRK09028 4 KKATKIVSAGRDKKWTKGVINPPVFRASTVVFDTVAEMRHaAKNRANGEMFYGRRGTPTHFAFQAAIVELEGGAGTALYP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 85 SGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAII 164
Cdd:PRK09028 84 SGAAAISNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITMEVQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 165 DIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKFDYMceFGGVM 244
Cdd:PRK09028 164 DVPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATANEKHWDQLREHSYL--MGQCT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 245 SPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVK-GGLKAAK 323
Cdd:PRK09028 242 SPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVLKqGDPKAVT 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 432179922 324 RFINSVKLAKIAVSLGDCETLIelpaaMTHAGYPKAR-LQEFDLTDSIVRLSVGIENVKDIIEDLDNAL 391
Cdd:PRK09028 322 ALVEGMQHFKMGFSWGGFESLI-----LGVFGINKLRtATNWDFSKPLIRLHIGLEDVDDLIADLEAGF 385
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
9-387 |
4.03e-66 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 214.74 E-value: 4.03e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 9 TLSIHGGAEKNHPKNALNPPIFMTSTYVFDDvkDAEdiMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASGMA 88
Cdd:TIGR01324 1 TRLIHSGRQPRFSQGSVNPPLQRASTVLFDS--HAA--QRRAKGELTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 89 AISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEGAIDKNTKVLYFETPANPNLAIIDIQQ 168
Cdd:TIGR01324 77 AVTNSILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 169 IVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGvAVSKDADYIKKLkFDYMCEFGGVMSPFN 248
Cdd:TIGR01324 157 IAKAARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIG-TVVANARTWDQL-REHSYLMGQMVDADD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 249 AWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKG-GLKAAKRFIN 327
Cdd:TIGR01324 235 AYTTLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSGLFSFVLQRlTQKQVHAFLD 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 328 SVKLAKIAVSLGDCETLIeLPAAMTHAGYPKARLqefDLTDSIVRLSVGIENVKDIIEDL 387
Cdd:TIGR01324 315 HLQLFGLGYSWGGYESLA-LCNQPELGHRPNIKR---NLEGPLIRVHIGLENVDDLKADL 370
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
6-391 |
3.40e-63 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 207.74 E-value: 3.40e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 6 GFDTLSIHGGaekNHPKNA---LNPPIFMTSTYVFDDVKdaedIMNFEKQGFIY-TRGNnPTLQLFEKRMAALEEGEDAV 81
Cdd:PRK05967 12 GINTRLAHDG---NDPGDYhgfVNPPVVHASTVLFPDAE----TMATRGQKYTYgTRGT-PTTDALCKAIDALEGSAGTI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 82 AFASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDcksVDFTEPK---AVEGAIDKNTKVLYFETPAN 158
Cdd:PRK05967 84 LVPSGLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVE---VEYYDPEigaGIAKLMRPNTKVVHTEAPGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 159 PNLAIIDIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVaVSKDADYIKKLKfDYMC 238
Cdd:PRK05967 161 NTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGT-VSANEKCWPQLL-EAHG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 239 EFGGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGG 318
Cdd:PRK05967 239 TLGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAAG 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 432179922 319 LKAAKR----FINSVKLAKIAVSLGDCETLielpaaMTHAGYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNAL 391
Cdd:PRK05967 319 PEKGKAkahaFLDALEIFGLGYSWGGYESL------ALHVKLGDRTVAKAPYAGPVIRLQIGLEDVPDLKADLERGF 389
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
24-391 |
1.10e-60 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 201.11 E-value: 1.10e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 24 ALNPPIFMTSTYVFDDVKDAEDIMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVAFASGMAAISSVLFSLLSPKDN 103
Cdd:PRK07050 27 SFVTPVARASTVVFPDLATMRALDWRQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQPSGLAAISLVYFGLVKAGDD 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 104 VVVHKTLYGSSFTVTHKLLPKYHIdckSVDFTEP---KAVEGAIDKNTKVLYFETPANPNLAIIDIQQIVRIAKTYGVKV 180
Cdd:PRK07050 107 VLIPDNAYGPNRDHGEWLARDFGI---TVRFYDPligAGIADLIQPNTRLIWLEAPGSVTMEVPDVPAITAAARARGVVT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 181 VVDNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKFDYMcEFGGVMSPFNAWLMLRGLKTLG 260
Cdd:PRK07050 184 AIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLARM-RLGIGVSADDCSLVLRGLPSLQ 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 261 LRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKGGLKAAK--RFINSVKLAKIAVSL 338
Cdd:PRK07050 263 VRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLFSVVFDERYSPAQvdAFVEALELFAIGWSW 342
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 432179922 339 GDCETLielpaAMTHAgYPKARLQEFDLTDSIVRLSVGIENVKDIIEDLDNAL 391
Cdd:PRK07050 343 GGACSL-----AMPYD-VASMRTAKWPHRGTLVRLYIGLEDEADLIADLEQAL 389
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
4-388 |
3.54e-59 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 197.23 E-value: 3.54e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 4 DYGFDTLSIHGGAEKNHPKNALNPPIFMTSTYVFDDVKDAED-IMNFEKQGFIYTRGNNPTLQLFEKRMAALEEGEDAVA 82
Cdd:PRK08114 3 DKKLDTQLVNAGRSKKYTQGSVNSVIQRASSLVFDSVEAKKHaTRNRANGELFYGRRGTLTHFSLQEAMCELEGGAGCAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 83 FASGMAAISSVLFSLLSPKDNVVVHKTLYGSSFTVTHKLLPKYHIdckSVDFTEPKAVEGA---IDKNTKVLYFETPANP 159
Cdd:PRK08114 83 YPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGV---TTTWFDPLIGADIaklIQPNTKVVFLESPGSI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 160 NLAIIDIQQIVRIAKTYGVKVVV--DNTFATPYFQRPLAFGADVVVHSATKYICGHGDALGGVAVSKDADYIKKLKFDYM 237
Cdd:PRK08114 160 TMEVHDVPAIVAAVRSVNPDAVImiDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVANARCWEQLRENSYL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 238 ceFGGVMSPFNAWLMLRGLKTLGLRMRQHEANAMAIAEFLKSHDSIEEVFYPGLADFRGHELAKRQMDGFGAVMSFEVKG 317
Cdd:PRK08114 240 --MGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFVLKK 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 432179922 318 GLKAAK--RFINSVKLAKIAVSLGDCETLI-----ELPAAMTHAGypkarlqEFDLTDSIVRLSVGIENVKDIIEDLD 388
Cdd:PRK08114 318 KLTDEQlaNYLDNFSLFSMAYSWGGFESLIlanqpEEIAAIRPAG-------EVDFTGTLIRLHIGLEDVDDLIADLA 388
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
64-222 |
4.66e-12 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 63.94 E-value: 4.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 64 LQLFEKRMAALEEG--EDAVAFASGMAAISSVLFSLLSPKDNVVVhkTLYGSSFTVTHKLLPKYhidCKSVDFTEPKAVE 141
Cdd:cd01494 2 LEELEEKLARLLQPgnDKAVFVPSGTGANEAALLALLGPGDEVIV--DANGHGSRYWVAAELAG---AKPVPVPVDDAGY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 142 GAID----------KNTKVLYFETPANPNLAIIDIQQIVRIAKTYGVKVVVDNTFATPY----FQRPLAFGADVVVHSAT 207
Cdd:cd01494 77 GGLDvaileelkakPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGAspapGVLIPEGGADVVTFSLH 156
|
170
....*....|....*
gi 432179922 208 KYICGHGdaLGGVAV 222
Cdd:cd01494 157 KNLGGEG--GGVVIV 169
|
|
| AHBA_syn |
cd00616 |
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal ... |
59-284 |
1.15e-10 |
|
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.
Pssm-ID: 99740 [Multi-domain] Cd Length: 352 Bit Score: 62.56 E-value: 1.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 59 GNNPTLQLFEKRMAALEEGEDAVAFASGMAAISSVLFSL-LSPKDNVVVhktlygSSFT-------VTH-KLLPKYhIDC 129
Cdd:cd00616 15 TLGPKVREFEKAFAEYLGVKYAVAVSSGTAALHLALRALgIGPGDEVIV------PSFTfvatanaILLlGATPVF-VDI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 130 KSVDFT-EPKAVEGAIDKNTKvlyfetpanpnlAII---------DIQQIVRIAKTYGVKVVVDN--TFATPY-FQRPLA 196
Cdd:cd00616 88 DPDTYNiDPELIEAAITPRTK------------AIIpvhlygnpaDMDAIMAIAKRHGLPVIEDAaqALGATYkGRKVGT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 197 FGaDVVVHS--ATKYICGhGDalGGVAVSKDADYIKKLKfdYMCEFGGV----------------MSPFNAWLMLRGLKT 258
Cdd:cd00616 156 FG-DAGAFSfhPTKNLTT-GE--GGAVVTNDEELAERAR--LLRNHGRDrdrfkyeheilgynyrLSEIQAAIGLAQLEK 229
|
250 260
....*....|....*....|....*.
gi 432179922 259 LGLRMRQHEANAMAIAEFLKSHDSIE 284
Cdd:cd00616 230 LDEIIARRREIAERYKELLADLPGIR 255
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
67-290 |
1.00e-09 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 59.66 E-value: 1.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 67 FEKRMAALEEGEDAVAFASG-MAAISSVLFSLLSPKDNVVVHK---TLYGSSFTVTHKLLPKYHIDCKSVDFTEPKAVEG 142
Cdd:cd00609 48 WLGRRGGVDVPPEEIVVTNGaQEALSLLLRALLNPGDEVLVPDptyPGYEAAARLAGAEVVPVPLDEEGGFLLDLELLEA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 143 AIDKNTKVLYFETPANPNLAIID---IQQIVRIAKTYGVKVVVDNTFA----TPYFQRPLAFGAD----VVVHSATKyic 211
Cdd:cd00609 128 AKTPKTKLLYLNNPNNPTGAVLSeeeLEELAELAKKHGILIISDEAYAelvyDGEPPPALALLDAyervIVLRSFSK--- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 212 ghgdALG------GVAVSKDADYIKKLKFDYMCEFGGVmSPFNAWLMLRGLKTLG---LRMRQH-EANAMAIAEFLKSHD 281
Cdd:cd00609 205 ----TFGlpglriGYLIAPPEELLERLKKLLPYTTSGP-STLSQAAAAAALDDGEehlEELRERyRRRRDALLEALKELG 279
|
....*....
gi 432179922 282 SIEEVFYPG 290
Cdd:cd00609 280 PLVVVKPSG 288
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
59-187 |
5.75e-08 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 54.23 E-value: 5.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 59 GNNPTLQLFEKRMAAL--------EEGEDAVAFASGM-AAISSVLFSLLSPKDNVVVHkTLYGSSFTVTHKLL------- 122
Cdd:pfam00155 36 GPTDGHPELREALAKFlgrspvlkLDREAAVVFGSGAgANIEALIFLLANPGDAILVP-APTYASYIRIARLAggevvry 114
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 432179922 123 PKYHIDCKSVDFtepKAVEGAIDKNTKVLYFETPANP---NLAIIDIQQIVRIAKTYGVKVVVDNTFA 187
Cdd:pfam00155 115 PLYDSNDFHLDF---DALEAALKEKPKVVLHTSPHNPtgtVATLEELEKLLDLAKEHNILLLVDEAYA 179
|
|
| WecE |
COG0399 |
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis]; |
56-284 |
5.86e-08 |
|
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440168 Cd Length: 364 Bit Score: 53.92 E-value: 5.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 56 YTRGnnPTLQLFEKRMAALEEGEDAVAFASGMAAISSVLFSL-LSPKDNVVVhktlygSSFT-------VTH-KLLPKYh 126
Cdd:COG0399 26 LTLG--PEVKEFEEEFAAYLGVKHAVAVSSGTAALHLALRALgIGPGDEVIT------PAFTfvatanaILYvGATPVF- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 127 IDCKSVDFT-EPKAVEGAIDKNTKVL----YFETPAnpnlaiiDIQQIVRIAKTYGVKVVVDNTfatpyfQrplAFGA-- 199
Cdd:COG0399 97 VDIDPDTYNiDPEALEAAITPRTKAIipvhLYGQPA-------DMDAIMAIAKKHGLKVIEDAA------Q---ALGAty 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 200 ---------DVVVHS--ATKYIcGHGDalGGVAVSKDADYIKKLKF----------DYMCEFGGV---MSPFNAWLMLRG 255
Cdd:COG0399 161 kgkkvgtfgDAGCFSfyPTKNL-TTGE--GGAVVTNDEELAERARSlrnhgrdrdaKYEHVELGYnyrMDELQAAIGLAQ 237
|
250 260
....*....|....*....|....*....
gi 432179922 256 LKTLGLRMRQHEANAMAIAEFLKSHDSIE 284
Cdd:COG0399 238 LKRLDEFIARRRAIAARYREALADLPGLT 266
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
72-319 |
1.14e-04 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 43.76 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 72 AALEEGEDAVAFASGMAAISSVLfsllsPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTE-----PKAVEGAIDK 146
Cdd:cd00613 84 ASLQDEATAAAEAAGLAAIRAYH-----KRNKVLVPDSAHPTNPAVARTRGEPLGIEVVEVPSDEggtvdLEALKEEVSE 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 147 NTKVLYFEtpaNPN-LAII--DIQQIVRIAKTYGVKVVVD-NTFATPYFQRPLAFGADVVVHSATKYICGHGdaLGG--- 219
Cdd:cd00613 159 EVAALMVQ---YPNtLGVFedLIKEIADIAHSAGALVYVDgDNLNLTGLKPPGEYGADIVVGNLQKTGVPHG--GGGpga 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 220 -----------------VAVSKDADYIKKLKFDY-------MCEFGGVMSPFN-AWLMLR-----------GLKTLGLRm 263
Cdd:cd00613 234 gffavkkelvrflpgrlVGVTKDAEGNRAFRLALqtreqhiRREKATSNICTGqALLALMaamyivylgpeGLKEIAER- 312
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 432179922 264 rqheanAMAIAEFLKSHdsIEEVFYPGLAD-FRGHE---------------LAKRQMDG--FGAVMSFEVKGGL 319
Cdd:cd00613 313 ------AHLNANYLAKR--LKEVGGVLPFNgPFFHEfvlrlpplygiraedLAKALIDGgfHAPTMYLPVDGTL 378
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
78-183 |
2.42e-04 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 42.82 E-value: 2.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 78 EDAVAFASGM-AAISSVLFSL--LSPKDNVVVHKTLYGSSFTVTHKLLPKYHIDCKSVDFTE-----PKAVEGAIDKNTK 149
Cdd:COG0520 77 PDEIIFTRGTtEAINLVAYGLgrLKPGDEILITEMEHHSNIVPWQELAERTGAEVRVIPLDEdgeldLEALEALLTPRTK 156
|
90 100 110
....*....|....*....|....*....|....*
gi 432179922 150 VLYFeTPANPNLAII-DIQQIVRIAKTYGVKVVVD 183
Cdd:COG0520 157 LVAV-THVSNVTGTVnPVKEIAALAHAHGALVLVD 190
|
|
| PRK06225 |
PRK06225 |
pyridoxal phosphate-dependent aminotransferase; |
76-225 |
2.76e-04 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235749 [Multi-domain] Cd Length: 380 Bit Score: 42.82 E-value: 2.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 76 EGEDAVAFASGMAAISSVLFSLLSPKDNVVV----HKT--LYGSSFTVTHKLLPKYHIDCkSVDFTePKAVEGAIDKNTK 149
Cdd:PRK06225 82 DDDEALITAGATESLYLVMRAFLSPGDNAVTpdpgYLIidNFASRFGAEVIEVPIYSEEC-NYKLT-PELVKENMDENTR 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 150 VLYFETPANPnLAII----DIQQIVRIAKTYGVKVVVDNTFATPYFQRPLAFGAD----VVVHSATKyICG-HGDALGGV 220
Cdd:PRK06225 160 LIYLIDPLNP-LGSSyteeEIKEFAEIARDNDAFLLHDCTYRDFAREHTLAAEYApehtVTSYSFSK-IFGmAGLRIGAV 237
|
....*
gi 432179922 221 AVSKD 225
Cdd:PRK06225 238 VATPD 242
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
78-184 |
5.90e-04 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 41.65 E-value: 5.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432179922 78 EDAVAFASGMAAISSVLFSLLSPKDNVVVHK---TLYGSSFT------VTHKLLPK--YHIDcksvdftePKAVEGAIDK 146
Cdd:COG0436 91 DEILVTNGAKEALALALLALLNPGDEVLVPDpgyPSYRAAVRlaggkpVPVPLDEEngFLPD--------PEALEAAITP 162
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 432179922 147 NTKVLYFETPANPNLAII---DIQQIVRIAKTYGVKVVVDN 184
Cdd:COG0436 163 RTKAIVLNSPNNPTGAVYsreELEALAELAREHDLLVISDE 203
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
136-208 |
6.29e-04 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 41.46 E-value: 6.29e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 432179922 136 EPKAVEGAIDKNTKVLYFeTPANpNL--AIIDIQQIVRIAKTYGVKVVVDNTFATPYfqRPL---AFGADVVVHSATK 208
Cdd:pfam00266 128 DLDELEKLITPKTKLVAI-THVS-NVtgTIQPVPEIGKLAHQYGALVLVDAAQAIGH--RPIdvqKLGVDFLAFSGHK 201
|
|
| PRK05764 |
PRK05764 |
aspartate aminotransferase; Provisional |
137-183 |
8.21e-03 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 235596 Cd Length: 393 Bit Score: 38.18 E-value: 8.21e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 432179922 137 PKAVEGAIDKNTKVLYFETPANPNLAII---DIQQIVRIAKTYGVKVVVD 183
Cdd:PRK05764 154 VEQLEAAITPKTKALILNSPSNPTGAVYspeELEAIADVAVEHDIWVLSD 203
|
|
| |
