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Conserved domains on  [gi|312217135|emb|CBX97084|]
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hypothetical protein LEMA_P102150.1 [Plenodomus lingam JN3]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
129-497 3.67e-95

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 298.75  E-value: 3.67e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 129 AVSRCSAAVSGHGDNILAVNFSPeSSSRMASGSGDKTVRIWDCDTGTPVHTMKGHTRWVLAVCYSPDGSLLASGGYDNEV 208
Cdd:COG2319   66 AAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 209 RIWDPSTGKQIgGPLKGHANFITSLSWEPyhlqePGRpRVASSSKDGTVRVWDAIGGKIEYALAGHKSSVTCVKWGGTGR 288
Cdd:COG2319  145 RLWDLATGKLL-RTLTGHSGAVTSVAFSP-----DGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 289 -IYTASHDKTIKVWNASTGSLINTLSGHAHWVNHLALSTDfvlrtsyhdhtrkvpstpeeklakakqrfekaatlnGeiv 367
Cdd:COG2319  218 lLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD------------------------------------G--- 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 368 ERLATASEDCTIILWTpLSSTKPVTRMTGHQKQINQVTFSPDGLLLASAAWDNHVKLWSARDGKFLNTLRAHVGPVYMTC 447
Cdd:COG2319  259 RLLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 312217135 448 FSADSRLLASCSKDTTLKVWDMRTGKLKEDLPGHKDQVFALDWSPDGDRV 497
Cdd:COG2319  338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
129-497 3.67e-95

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 298.75  E-value: 3.67e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 129 AVSRCSAAVSGHGDNILAVNFSPeSSSRMASGSGDKTVRIWDCDTGTPVHTMKGHTRWVLAVCYSPDGSLLASGGYDNEV 208
Cdd:COG2319   66 AAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 209 RIWDPSTGKQIgGPLKGHANFITSLSWEPyhlqePGRpRVASSSKDGTVRVWDAIGGKIEYALAGHKSSVTCVKWGGTGR 288
Cdd:COG2319  145 RLWDLATGKLL-RTLTGHSGAVTSVAFSP-----DGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 289 -IYTASHDKTIKVWNASTGSLINTLSGHAHWVNHLALSTDfvlrtsyhdhtrkvpstpeeklakakqrfekaatlnGeiv 367
Cdd:COG2319  218 lLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD------------------------------------G--- 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 368 ERLATASEDCTIILWTpLSSTKPVTRMTGHQKQINQVTFSPDGLLLASAAWDNHVKLWSARDGKFLNTLRAHVGPVYMTC 447
Cdd:COG2319  259 RLLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 312217135 448 FSADSRLLASCSKDTTLKVWDMRTGKLKEDLPGHKDQVFALDWSPDGDRV 497
Cdd:COG2319  338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 133-468 3.13e-84

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 266.12  E-value: 3.13e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 133 CSAAVSGHGDNILAVNFSPeSSSRMASGSGDKTVRIWDCDTGTPVHTMKGHTRWVLAVCYSPDGSLLASGGYDNEVRIWD 212
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 213 PSTGKQIgGPLKGHANFITSLSWEPYhlqepgRPRVASSSKDGTVRVWDAIGGKIEYALAGHKSSVTCVKWGGTGR-IYT 291
Cdd:cd00200   80 LETGECV-RTLTGHTSYVSSVAFSPD------GRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTfVAS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 292 ASHDKTIKVWNASTGSLINTLSGHAHWVNHLALSTDfvlrtsyhdhtrkvpstpeeklakakqrfekaatlngeiVERLA 371
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD---------------------------------------GEKLL 193

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 372 TASEDCTIILWTpLSSTKPVTRMTGHQKQINQVTFSPDGLLLASAAWDNHVKLWSARDGKFLNTLRAHVGPVYMTCFSAD 451
Cdd:cd00200  194 SSSSDGTIKLWD-LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPD 272

                        330
                 ....*....|....*..
gi 312217135 452 SRLLASCSKDTTLKVWD 468
Cdd:cd00200  273 GKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 155-325 5.83e-13

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 72.04  E-value: 5.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 155 SRMASGSGDKTVRIWDCDTGTPVHTMKGHTRWVLAVCYSP-DGSLLASGGYDNEVRIWDPSTGKQIGgPLKGHANfITSL 233
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIG-TIKTKAN-ICCV 623

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 234 SWEpyhlQEPGRpRVASSSKDGTVRVWDAIGGKIEY-ALAGHKSSVTCVKWGGTGRIYTASHDKTIKVWNAS-TGSLIN- 310
Cdd:PLN00181 624 QFP----SESGR-SLAFGSADHKVYYYDLRNPKLPLcTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSmSISGINe 698

                        170
                 ....*....|....*....
gi 312217135 311 ----TLSGHAHWVNHLALS 325
Cdd:PLN00181 699 tplhSFMGHTNVKNFVGLS 717
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 173-212 2.85e-12

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 61.17  E-value: 2.85e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 312217135   173 TGTPVHTMKGHTRWVLAVCYSPDGSLLASGGYDNEVRIWD 212
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
174-212 7.33e-11

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 57.36  E-value: 7.33e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 312217135  174 GTPVHTMKGHTRWVLAVCYSPDGSLLASGGYDNEVRIWD 212
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
129-497 3.67e-95

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 298.75  E-value: 3.67e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 129 AVSRCSAAVSGHGDNILAVNFSPeSSSRMASGSGDKTVRIWDCDTGTPVHTMKGHTRWVLAVCYSPDGSLLASGGYDNEV 208
Cdd:COG2319   66 AAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 209 RIWDPSTGKQIgGPLKGHANFITSLSWEPyhlqePGRpRVASSSKDGTVRVWDAIGGKIEYALAGHKSSVTCVKWGGTGR 288
Cdd:COG2319  145 RLWDLATGKLL-RTLTGHSGAVTSVAFSP-----DGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 289 -IYTASHDKTIKVWNASTGSLINTLSGHAHWVNHLALSTDfvlrtsyhdhtrkvpstpeeklakakqrfekaatlnGeiv 367
Cdd:COG2319  218 lLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD------------------------------------G--- 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 368 ERLATASEDCTIILWTpLSSTKPVTRMTGHQKQINQVTFSPDGLLLASAAWDNHVKLWSARDGKFLNTLRAHVGPVYMTC 447
Cdd:COG2319  259 RLLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 312217135 448 FSADSRLLASCSKDTTLKVWDMRTGKLKEDLPGHKDQVFALDWSPDGDRV 497
Cdd:COG2319  338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387
WD40 COG2319
WD40 repeat [General function prediction only];
131-471 1.70e-90

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 286.42  E-value: 1.70e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 131 SRCSAAVSGHGDNILAVNFSPeSSSRMASGSGDKTVRIWDCDTGTPVHTMKGHTRWVLAVCYSPDGSLLASGGYDNEVRI 210
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 211 WDPSTGKQIgGPLKGHANFITSLSWEPyhlqePGRpRVASSSKDGTVRVWDAIGGKIEYALAGHKSSVTCVKWGGTGR-I 289
Cdd:COG2319  189 WDLATGKLL-RTLTGHTGAVRSVAFSP-----DGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRlL 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 290 YTASHDKTIKVWNASTGSLINTLSGHAHWVNHLALSTDfvlrtsyhdhtrkvpstpeeklakakqrfekaatlnGeivER 369
Cdd:COG2319  262 ASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD------------------------------------G---KL 302

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 370 LATASEDCTIILWTpLSSTKPVTRMTGHQKQINQVTFSPDGLLLASAAWDNHVKLWSARDGKFLNTLRAHVGPVYMTCFS 449
Cdd:COG2319  303 LASGSDDGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                        330       340
                 ....*....|....*....|..
gi 312217135 450 ADSRLLASCSKDTTLKVWDMRT 471
Cdd:COG2319  382 PDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 133-468 3.13e-84

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 266.12  E-value: 3.13e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 133 CSAAVSGHGDNILAVNFSPeSSSRMASGSGDKTVRIWDCDTGTPVHTMKGHTRWVLAVCYSPDGSLLASGGYDNEVRIWD 212
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 213 PSTGKQIgGPLKGHANFITSLSWEPYhlqepgRPRVASSSKDGTVRVWDAIGGKIEYALAGHKSSVTCVKWGGTGR-IYT 291
Cdd:cd00200   80 LETGECV-RTLTGHTSYVSSVAFSPD------GRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTfVAS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 292 ASHDKTIKVWNASTGSLINTLSGHAHWVNHLALSTDfvlrtsyhdhtrkvpstpeeklakakqrfekaatlngeiVERLA 371
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD---------------------------------------GEKLL 193

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 372 TASEDCTIILWTpLSSTKPVTRMTGHQKQINQVTFSPDGLLLASAAWDNHVKLWSARDGKFLNTLRAHVGPVYMTCFSAD 451
Cdd:cd00200  194 SSSSDGTIKLWD-LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPD 272

                        330
                 ....*....|....*..
gi 312217135 452 SRLLASCSKDTTLKVWD 468
Cdd:cd00200  273 GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
120-497 3.59e-80

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 259.46  E-value: 3.59e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 120 APQAVFRVKAVSRCSAAVSGHGDNILAVNFSPESSSRMASGSGDKTVRIWDCDTGTPVHTMKGHTRWVLAVCYSPDGSLL 199
Cdd:COG2319   14 ADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 200 ASGGYDNEVRIWDPSTGKQIGgPLKGHANFITSLSWEPyhlqePGRpRVASSSKDGTVRVWDAIGGKIEYALAGHKSSVT 279
Cdd:COG2319   94 ASASADGTVRLWDLATGLLLR-TLTGHTGAVRSVAFSP-----DGK-TLASGSADGTVRLWDLATGKLLRTLTGHSGAVT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 280 CVKWGGTGR-IYTASHDKTIKVWNASTGSLINTLSGHAHWVNHLALSTDfvlrtsyhdhtrkvpstpeeklakakqrfek 358
Cdd:COG2319  167 SVAFSPDGKlLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD------------------------------- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 359 aatlnGEiveRLATASEDCTIILWTpLSSTKPVTRMTGHQKQINQVTFSPDGLLLASAAWDNHVKLWSARDGKFLNTLRA 438
Cdd:COG2319  216 -----GK---LLASGSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 312217135 439 HVGPVYMTCFSADSRLLASCSKDTTLKVWDMRTGKLKEDLPGHKDQVFALDWSPDGDRV 497
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL 345
WD40 COG2319
WD40 repeat [General function prediction only];
158-497 2.76e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 225.56  E-value: 2.76e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 158 ASGSGDKTVRIWDCDTGTPVHTMKGHTRWVLAVCYSPDGSLLASGGYDNEVRIWDPSTGKQIGgPLKGHANFITSLSWEP 237
Cdd:COG2319   10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA-TLLGHTAAVLSVAFSP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 238 yhlqepGRPRVASSSKDGTVRVWDAIGGKIEYALAGHKSSVTCVKWGGTG-RIYTASHDKTIKVWNASTGSLINTLSGHA 316
Cdd:COG2319   89 ------DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 317 HWVNHLALSTDfvlrtsyhdhtrkvpstpeeklakakqrfekaatlnGEiveRLATASEDCTIILWTpLSSTKPVTRMTG 396
Cdd:COG2319  163 GAVTSVAFSPD------------------------------------GK---LLASGSDDGTVRLWD-LATGKLLRTLTG 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 397 HQKQINQVTFSPDGLLLASAAWDNHVKLWSARDGKFLNTLRAHVGPVYMTCFSADSRLLASCSKDTTLKVWDMRTGKLKE 476
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282

                        330       340
                 ....*....|....*....|.
gi 312217135 477 DLPGHKDQVFALDWSPDGDRV 497
Cdd:COG2319  283 TLTGHSGGVNSVAFSPDGKLL 303
WD40 COG2319
WD40 repeat [General function prediction only];
193-497 4.76e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 182.03  E-value: 4.76e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 193 SPDGSLLASGGYDNEVRIWDPSTGKQIGGPLKGHANFITSLSWepyhlqePGRPRVASSSKDGTVRVWDAIGGKIEYALA 272
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAAS-------PDGARLAAGAGDLTLLLLDAAAGALLATLL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 273 GHKSSVTCVKWGGTGR-IYTASHDKTIKVWNASTGSLINTLSGHAHWVNHLALSTDfvlrtsyhdhtrkvpstpeeklak 351
Cdd:COG2319   76 GHTAAVLSVAFSPDGRlLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD------------------------ 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 352 akqrfekaatlnGEiveRLATASEDCTIILWTpLSSTKPVTRMTGHQKQINQVTFSPDGLLLASAAWDNHVKLWSARDGK 431
Cdd:COG2319  132 ------------GK---TLASGSADGTVRLWD-LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312217135 432 FLNTLRAHVGPVYMTCFSADSRLLASCSKDTTLKVWDMRTGKLKEDLPGHKDQVFALDWSPDGDRV 497
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLL 261
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 132-341 1.20e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 174.45  E-value: 1.20e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 132 RCSAAVSGHGDNILAVNFSPesSSRMASGSG-DKTVRIWDCDTGTPVHTMKGHTRWVLAVCYSPDGSLLASGGYDNEVRI 210
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSP--DGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 211 WDPSTGKQIgGPLKGHANFITSLSWepyhlqEPGRPRVASSSKDGTVRVWDAIGGKIEYALAGHKSSVTCVKWGGTGRIY 290
Cdd:cd00200  162 WDLRTGKCV-ATLTGHTGEVNSVAF------SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLL 234

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 312217135 291 T-ASHDKTIKVWNASTGSLINTLSGHAHWVNHLALSTD-FVLRTSYHDHTRKV 341
Cdd:cd00200  235 AsGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDgKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 132-302 1.92e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 168.67  E-value: 1.92e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 132 RCSAAVSGHGDNILAVNFSPeSSSRMASGSGDKTVRIWDCDTGTPVHTMKGHTRWVLAVCYSPDGSLLASGGYDNEVRIW 211
Cdd:cd00200  126 KCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 212 DPSTGKQIgGPLKGHANFITSLSWepyhlqEPGRPRVASSSKDGTVRVWDAIGGKIEYALAGHKSSVTCVKWGGTG-RIY 290
Cdd:cd00200  205 DLSTGKCL-GTLRGHENGVNSVAF------SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLA 277

                        170
                 ....*....|..
gi 312217135 291 TASHDKTIKVWN 302
Cdd:cd00200  278 SGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 308-499 3.50e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.99  E-value: 3.50e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 308 LINTLSGHAHWVNHLALSTDFvlrtsyhdhtrkvpstpeeklakakqrfekaatlngeivERLATASEDCTIILWTpLSS 387
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDG---------------------------------------KLLATGSGDGTIKVWD-LET 40

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 388 TKPVTRMTGHQKQINQVTFSPDGLLLASAAWDNHVKLWSARDGKFLNTLRAHVGPVYMTCFSADSRLLASCSKDTTLKVW 467
Cdd:cd00200   41 GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW 120

                        170       180       190
                 ....*....|....*....|....*....|..
gi 312217135 468 DMRTGKLKEDLPGHKDQVFALDWSPDGDRVTV 499
Cdd:cd00200  121 DVETGKCLTTLRGHTDWVNSVAFSPDGTFVAS 152
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 155-325 5.83e-13

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 72.04  E-value: 5.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 155 SRMASGSGDKTVRIWDCDTGTPVHTMKGHTRWVLAVCYSP-DGSLLASGGYDNEVRIWDPSTGKQIGgPLKGHANfITSL 233
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIG-TIKTKAN-ICCV 623

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 234 SWEpyhlQEPGRpRVASSSKDGTVRVWDAIGGKIEY-ALAGHKSSVTCVKWGGTGRIYTASHDKTIKVWNAS-TGSLIN- 310
Cdd:PLN00181 624 QFP----SESGR-SLAFGSADHKVYYYDLRNPKLPLcTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSmSISGINe 698

                        170
                 ....*....|....*....
gi 312217135 311 ----TLSGHAHWVNHLALS 325
Cdd:PLN00181 699 tplhSFMGHTNVKNFVGLS 717
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 173-212 2.85e-12

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 61.17  E-value: 2.85e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 312217135   173 TGTPVHTMKGHTRWVLAVCYSPDGSLLASGGYDNEVRIWD 212
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
174-212 7.33e-11

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 57.36  E-value: 7.33e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 312217135  174 GTPVHTMKGHTRWVLAVCYSPDGSLLASGGYDNEVRIWD 212
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 117-303 3.10e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 62.99  E-value: 3.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 117 LQYAPQAVFRVKAVSRCSAA---VSGHGDNILAVNFSPESSSRMASGSGDKTVRIWDC-------DTGTPVHTMKGHTRW 186
Cdd:PTZ00421  48 QQLGSTAVLKHTDYGKLASNppiLLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKK 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 187 VLAVCYSPDG-SLLASGGYDNEVRIWDPSTGKQiGGPLKGHANFITSLSWepyHLQEpgrPRVASSSKDGTVRVWDAIGG 265
Cdd:PTZ00421 128 VGIVSFHPSAmNVLASAGADMVVNVWDVERGKA-VEVIKCHSDQITSLEW---NLDG---SLLCTTSKDKKLNIIDPRDG 200

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 312217135 266 KIEYALAGHKSSVT--CVKWGGTGRIYT----ASHDKTIKVWNA 303
Cdd:PTZ00421 201 TIVSSVEAHASAKSqrCLWAKRKDLIITlgcsKSQQRQIMLWDT 244
PTZ00421 PTZ00421
coronin; Provisional
 329-474 2.36e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 60.29  E-value: 2.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 329 VLRtsyHDHTRKVPSTPEEKLAKAKQRFEKAatLNGEIVERLATASEDCTIILWT------PLSSTKPVTRMTGHQKQIN 402
Cdd:PTZ00421  55 VLK---HTDYGKLASNPPILLGQEGPIIDVA--FNPFDPQKLFTASEDGTIMGWGipeeglTQNISDPIVHLQGHTKKVG 129

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312217135 403 QVTFSPDGL-LLASAAWDNHVKLWSARDGKFLNTLRAHVGPVYMTCFSADSRLLASCSKDTTLKVWDMRTGKL 474
Cdd:PTZ00421 130 IVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTI 202
PTZ00420 PTZ00420
coronin; Provisional
 139-313 3.21e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 59.96  E-value: 3.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 139 GHGDNILAVNFSPESSSRMASGSGDKTVRIWDC--------DTGTPVHTMKGHTRWVLAVCYSP-DGSLLASGGYDNEVR 209
Cdd:PTZ00420  72 GHTSSILDLQFNPCFSEILASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDWNPmNYYIMCSSGFDSFVN 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 210 IWDPSTGK---QIGGPLKghanfITSLSW-------------EPYHLQEPGRPRVASS--SKDG---TVRVW-DAIGGKI 267
Cdd:PTZ00420 152 IWDIENEKrafQINMPKK-----LSSLKWnikgnllsgtcvgKHMHIIDPRKQEIASSfhIHDGgknTKNIWiDGLGGDD 226

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 312217135 268 EYALAghkssvtcvkwggTGriYTASHDKTIKVWN-ASTGSLINTLS 313
Cdd:PTZ00420 227 NYILS-------------TG--FSKNNMREMKLWDlKNTTSALVTMS 258
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 187-425 5.52e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 59.33  E-value: 5.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 187 VLAVCYSPDGSLLASGGYDNEVRIWDPST----GKQIGGP---LKGHANfITSLSWEPYHlqepgRPRVASSSKDGTVRV 259
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESiikdGRDIHYPvveLASRSK-LSGICWNSYI-----KSQVASSNFEGVVQV 559

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 260 WDAIGGKIEYALAGHKSSVTCVKWGGTGRIYTA--SHDKTIKVWNASTGSLINTlsghahwvnhlalstdfvLRTSYHDH 337
Cdd:PLN00181 560 WDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAsgSDDGSVKLWSINQGVSIGT------------------IKTKANIC 621

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 338 TRKVPStpeeklakakqrfekaatlngEIVERLATASEDCTIILWTPLSSTKPVTRMTGHQKQINQVTFSpDGLLLASAA 417
Cdd:PLN00181 622 CVQFPS---------------------ESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSS 679


                 ....*...
gi 312217135 418 WDNHVKLW 425
Cdd:PLN00181 680 TDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 387-426 3.17e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 3.17e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 312217135   387 STKPVTRMTGHQKQINQVTFSPDGLLLASAAWDNHVKLWS 426
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 429-468 4.61e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 4.61e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 312217135   429 DGKFLNTLRAHVGPVYMTCFSADSRLLASCSKDTTLKVWD 468
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
389-426 1.12e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 1.12e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 312217135  389 KPVTRMTGHQKQINQVTFSPDGLLLASAAWDNHVKLWS 426
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
430-468 2.95e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 2.95e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 312217135  430 GKFLNTLRAHVGPVYMTCFSADSRLLASCSKDTTLKVWD 468
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 176-261 6.20e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 52.64  E-value: 6.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 176 PVHTMKGHTRWVLAVCYSPDGS-LLASGGYDNEVRIW-----DPSTgKQIGGP---LKGHANFITSLSWEP--YHLqepg 244
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPCFSeILASGSEDLTIRVWeiphnDESV-KEIKDPqciLKGHKKKISIIDWNPmnYYI---- 140

                         90
                 ....*....|....*..
gi 312217135 245 rprVASSSKDGTVRVWD 261
Cdd:PTZ00420 141 ---MCSSGFDSFVNIWD 154
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 100-261 8.14e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.40  E-value: 8.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 100 YNALVKSGKASAESEIVLQyapqaVFRVkAVSRCSAAVSGHGDNILAVNFSPESSSRMASGSGDKTVRIWDCDTGTPVHT 179
Cdd:PLN00181 540 WNSYIKSQVASSNFEGVVQ-----VWDV-ARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGT 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 180 MKGHTRWVLAVCYSPDGSLLASGGYDNEVRIWDPSTGKQIGGPLKGHANFITslswepyHLQEPGRPRVASSSKDGTVRV 259
Cdd:PLN00181 614 IKTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVS-------YVRFVDSSTLVSSSTDNTLKL 686


                 ..
gi 312217135 260 WD 261
Cdd:PLN00181 687 WD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 132-170 2.01e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 2.01e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 312217135   132 RCSAAVSGHGDNILAVNFSPeSSSRMASGSGDKTVRIWD 170
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 265-302 2.66e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.66e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 312217135   265 GKIEYALAGHKSSVTCVKWGGTGR-IYTASHDKTIKVWN 302
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKyLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 190-284 4.58e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 45.35  E-value: 4.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135  190 VCYSPDGSLLASGGYDNEV--------RIWdpstgkqiGGPLKGHANFITSLSWEPyhlqePGRpRVASSSKDGTVRVWD 261
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELllhrlnwqRVW--------TLSPDKEDLEVTSLAWRP-----DGK-LLAVGYSDGTVRLLD 66

                          90       100
                  ....*....|....*....|...
gi 312217135  262 AIGGKIEYALAGHKSSVTCVKWG 284
Cdd:pfam12894  67 AENGKIVHHFSAGSDLITCLGWG 89
WD40 pfam00400
WD domain, G-beta repeat;
265-302 4.87e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 4.87e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 312217135  265 GKIEYALAGHKSSVTCVKWGGTGR-IYTASHDKTIKVWN 302
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
131-170 1.12e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.12e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 312217135  131 SRCSAAVSGHGDNILAVNFSPeSSSRMASGSGDKTVRIWD 170
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 363-474 2.20e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 363 NGEIVERLATASEDCTIILWTpLSSTKPVTRMTGHQKQINQVTFSP-DGLLLASAAWDNHVKLWSARDGKFLNTLRAHVG 441
Cdd:PLN00181 541 NSYIKSQVASSNFEGVVQVWD-VARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN 619

                         90       100       110
                 ....*....|....*....|....*....|...
gi 312217135 442 PVYMTCFSADSRLLASCSKDTTLKVWDMRTGKL 474
Cdd:PLN00181 620 ICCVQFPSESGRSLAFGSADHKVYYYDLRNPKL 652
WD40 COG2319
WD40 repeat [General function prediction only];
406-508 4.39e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 4.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 406 FSPDGLLLASAAWDNHVKLWSARDGKFLNTLRAHVGPVYMTCFSADSRLLASCSKDTTLKVWDMRTGKLKEDLPGHKDQV 485
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                         90       100
                 ....*....|....*....|....
gi 312217135 486 FALDWSPDGDR-VTVVLAYTQWIW 508
Cdd:COG2319   82 LSVAFSPDGRLlASASADGTVRLW 105
WD40 pfam00400
WD domain, G-beta repeat;
223-261 4.57e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 4.57e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 312217135  223 LKGHANFITSLSWEPYHlqepgrPRVASSSKDGTVRVWD 261
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDG------KLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
403-504 4.70e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.46  E-value: 4.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 403 QVTFSPDG-LLLASAAWDNHVKLWSARDGKFLNTLRAHVGPVYMTcFSADS-RLLASCSKDTT----LKVWDMRTGKLKE 476
Cdd:COG3391  114 GLAVDPDGgRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIA-VDPDGkRLYVANSGSNTvsviVSVIDTATGKVVA 192

                         90       100
                 ....*....|....*....|....*...
gi 312217135 477 DLPGHkDQVFALDWSPDGDRVTVVLAYT 504
Cdd:COG3391  193 TIPVG-GGPVGVAVSPDGRRLYVANRGS 219
PTZ00420 PTZ00420
coronin; Provisional
 436-492 1.71e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 1.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 312217135 436 LRAHVGPV----YMTCFSadsRLLASCSKDTTLKVWDMR-----TGKLKED---LPGHKDQVFALDWSP 492
Cdd:PTZ00420  70 LKGHTSSIldlqFNPCFS---EILASGSEDLTIRVWEIPhndesVKEIKDPqciLKGHKKKISIIDWNP 135
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 408-476 2.47e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 43.91  E-value: 2.47e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 312217135  408 PDGLLLASAAWDNHVKLWSARDGKFLNTLRAHVGPVYMTCFSADSRLLASCSKDTTLKVWDMRTGKLKE 476
Cdd:pfam20426  92 SENFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSE 160
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 187-235 2.69e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.34  E-value: 2.69e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 312217135  187 VLAVCYSPDGSLLASGGYDNEVRIWDPSTGKQIGGpLKGHANFITSLSW 235
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHH-FSAGSDLITCLGW 88
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 404-505 5.68e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.10  E-value: 5.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135  404 VTFSPDGlllASAAWdnhvklWSARDGKF---------LNTLRA--HVGPVYMT--CFSADSRLLASCSKDTTLKVWDMR 470
Cdd:COG4946   348 PAWSPDG---KSIAY------FSDASGEYelyiapadgSGEPKQltLGDLGRVFnpVWSPDGKKIAFTDNRGRLWVVDLA 418

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 312217135  471 TGKLKE-DLPGHKDQVFALDWSPDGDrvtvVLAYTQ 505
Cdd:COG4946   419 SGKVRKvDTDGYGDGISDLAWSPDSK----WLAYSK 450
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 139-235 6.65e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.77  E-value: 6.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 139 GHGDNILAVNFSpeSSSRMASGSGDKTVRIWDCDTG------TPVHTMKGHTRWVLAVCYSPDGSLLASGGYDNEVRIW- 211
Cdd:PLN00181 659 GHSKTVSYVRFV--DSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYh 736

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 312217135 212 ---------------DPSTGKQIGGPlkghANFITSLSW 235
Cdd:PLN00181 737 kafpmpvlsykfktiDPVSGLEVDDA----SQFISSVCW 771
PTZ00421 PTZ00421
coronin; Provisional
 187-316 2.95e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 40.65  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135 187 VLAVCYSP-DGSLLASGGYDNEVRIWD-PSTGKQ--IGGP---LKGHANFITSLSWEPyhlqePGRPRVASSSKDGTVRV 259
Cdd:PTZ00421  78 IIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGLTqnISDPivhLQGHTKKVGIVSFHP-----SAMNVLASAGADMVVNV 152

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 312217135 260 WDAIGGKIEYALAGHKSSVTCVKWGGTGRIY-TASHDKTIKVWNASTGSLINTLSGHA 316
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLcTTSKDKKLNIIDPRDGTIVSSVEAHA 210
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 131-256 3.69e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 40.06  E-value: 3.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312217135  131 SRCSAAVSGHGDNILavnfspesssrMASGSGDKTVRIWDCDTGTPVHTMKGHTRWVLAVCYSPDGSLLASGGYDNEVRI 210
Cdd:pfam20426  82 AQCFATLQTPSENFL-----------ISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMV 150

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 312217135  211 WDPSTGKQiggPLKGHANFITSLSWEPYHLQEpgRPR---------------------VASSSKDGT 256
Cdd:pfam20426 151 WEVLRGRS---SEKRSRNTQTEFPRKDHVIAE--TPFhilcghddiitclyvsveldiVISGSKDGT 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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