|
Name |
Accession |
Description |
Interval |
E-value |
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
3-397 |
7.06e-114 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 339.44 E-value: 7.06e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 3 KIKNKIFAWSLYDFASQPFSTIIVTFIYSAFFTTYIVE-DVDKGTLLWTRVISISAIIAAILSPILGALADRNSSRKLML 81
Cdd:COG2270 7 ASRREILAWALYDWANSAFSTVITTFVFPPYFTSVAALgDPAAATALWGYALAIAGLLVALLAPVLGAIADRSGRKKPFL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 82 IITTYISIIFIGLLYFPEKGDIMFSLIFFAIANVAFELSTVFYNSFLPDLSNNQNSGKISGNAWGFGFVGGLISLFICLS 161
Cdd:COG2270 87 AFFTLLGVLATAALFFVAPGGLWLGLLLFVLANIGFEGSLVFYNAFLPDIATPEEIGRVSGLGWALGYLGGVLLLLINLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 162 MF-------DVNQSSEIPKVSLLVAIWFFIFSVPAFIF-----LKEKKKLVTKKLSTLNQLKSTFKSIKEYKSIFKFFIA 229
Cdd:COG2270 167 LFlkpeafgLPDAGEAVRISFLLTALWWLLFALPLFLFlperpRPGPAPPRGAVRAGFRELRRTLRELRRYRDLLRFLLA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 230 RLFYNDALITIFSLGGIYAVGTVGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFFAPy 309
Cdd:COG2270 247 YFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLT- 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 310 tssPKITFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEFYGFFALTGKATSFVGPLLFGIISANF-SQQIALWIVIL 388
Cdd:COG2270 326 ---TALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTgSQRLGILSLIV 402
|
....*....
gi 330752538 389 LFCIGTIIF 397
Cdd:COG2270 403 FFVIGLVLL 411
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
11-397 |
8.21e-74 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 234.42 E-value: 8.21e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 11 WSLYDFASQPFSTIIVTFIYSAFFTTYIVEDVD--KGTLLWTRVISISAIIAAILSPILGALADRNSSRKLMLIITTYIS 88
Cdd:cd17482 1 WALYDWANSAFATTVTTAVFPVYFKAVAAQGASpvTSTALWGYANSIASLVIALLAPILGAIADYSGRKKRFLAFFCLIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 89 IIFIGLLYFPEKGDIMFSLIFFAIANVAFELSTVFYNSFLPDLSNNQNSGKISGNAWGFGFVGGLISLFICLSMFDVNQS 168
Cdd:cd17482 81 VVSTALLFFVTPGQWLLALLLFILANIGFSGANVFYDAFLPDVASPERMDRVSSLGYALGYIGGGLLFAVNLVLILGPDA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 169 SEIPKVS------LLVAIWFFIFSVPAfiflkekkklvtkklstlnqlkstfksikeyKSIFKFFIARLFYNDALITIFS 242
Cdd:cd17482 161 FGLDTAEavrlsfLSVALWWALFSIPL-------------------------------KQLLLFLIAYFFYIDGVQTIIR 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 243 LGGIYAVGTVGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFFAPYTSSpkitFWISAI 322
Cdd:cd17482 210 MATIYGAEEGKLGSSALILALLLTQFVAFPGALLFGWLAERFGAKRAILVSLVIYILICIYAYFMLTAWD----FWILAA 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 330752538 323 LLGLMVGPNQSSSRSLLSKIIPANKKNEFYGFFALTGKATSFVGPLLFGIISANF-SQQIALWIVILLFCIGTIIF 397
Cdd:cd17482 286 LIGLVQGGIQALSRSLFGRLIPKGKSAEFFGFYNISGKFAAIIGPLLFGLITQLTgSSRYGILSLIVLFVIGGILL 361
|
|
| MFS_Atg22_like |
cd17483 |
Autophagy-related protein 22 and similar proteins; member of the Major Facilitator Superfamily ... |
67-397 |
1.19e-38 |
|
Autophagy-related protein 22 and similar proteins; member of the Major Facilitator Superfamily of transporters; Atg22 (also known as Aut4) protein functions as a vacuolar effluxer which mediates the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation. Members of this family belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341036 Cd Length: 467 Bit Score: 144.34 E-value: 1.19e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 67 LGALADRNSSRKLMLIITTYI-SIIFIGLLYFPEKGDIMFSLIFFAIANVAFELSTVFYNSFLPDLSNN----------- 134
Cdd:cd17483 87 LGSLADYGNYRKRLLLTFTIIgSISSILFLFVPSPSLWWLAALLYIVSNICYGASLVFYNSFLPILARNhpdvraardkg 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 135 ----------------QNSGKISGNAWGFGFVGGLISLFICLSMFDVNQSSEIPK--VSLLVAIWFFIFSVPAFIF---- 192
Cdd:cd17483 167 sslsaeateeeisleeKVSSRISSLGFASGYVGGIIVQIISIIILFVLGNSIVSLriAIAVVGVWWLIFSVPTFLWlkpr 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 193 -LKEKKKLVTKKLSTLNQLKSTFKSIKEYKSIFKFFIARLFYNDALITIFSLGGIYAVGTVGFELSEVFILGIFLNISAA 271
Cdd:cd17483 247 pGPPLPGGSHPIFYSWKSLFRTLKHARKLPETFIFLLAWFFLSDGINTISSTAVLFAKSQLHMSTLQLILIGLLTPITAI 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 272 IGSFIFGYVED--KIGSKRAILITLYLLIFSTLIAFFAPYTSS----PKITFWISAILLGLMVGPNQSSSRSLLSKIIPA 345
Cdd:cd17483 327 LGAFFFPRIQRrfNLSTKTMLMLIVVLTALIPLYGLLGFFTGKfglkHPWEMYVLAVWFGFFLGGLQSYSRSLFSELIPP 406
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 330752538 346 NKKNEFYGFFALTGKATSFVGPLLFGIISANFSQQIALWIVILLFCIGTIIF 397
Cdd:cd17483 407 GHEAEFFSLFSITDKGSSWIGPLVVGAIIDATGNIRYGFIFLFALFVLPLPL 458
|
|
| ATG22 |
pfam11700 |
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which ... |
65-405 |
3.92e-38 |
|
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which eukaryotes recycle cellular nutrients during stress conditions. Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxes, which mediate the efflux of leucine and other amino acids resulting from autophagy. This family also includes other transporter proteins.
Pssm-ID: 371676 Cd Length: 479 Bit Score: 143.17 E-value: 3.92e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 65 PILGALADRNSSRKLMLIITTYISIIFIGLLYFPEKGDIMFSLIFFAIANVAFELSTVFYNSFLPDLSNN---------- 134
Cdd:pfam11700 88 ISLSGIADYGNYRKNLLIAFALIGSASTMLFLGVTPKKYLLGAILYIVGNTCFGASFVFLNSFLPLLARNdpelraaaea 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 135 ------------------QNSGKISGNAWGFGFVGGLISLFICLSM-FDVNQSSEIPKVSLLVAI-----WFFIFSVPAF 190
Cdd:pfam11700 168 lqdgesaitaeeydslelQLRTRISSRGFGIGYIGGILVQIISIIIvYALGSTASNNTWALRLAItfagcWWIIFTIPWA 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 191 IFLKE-----KKKLVTKKLSTLNQLKSTFKSIKEYKSIFKFFIARLFYNDALITIFSLGGIYAVGTVGFELSEVFILGIF 265
Cdd:pfam11700 248 LWLRPrpgppLPSGLNYLIYGWKQLGRTLKQARKLKDALLFLVAWFLLSDGIATVSSTAVLFAKTELGMSTSQLTLLNIV 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 266 LNISAAIGSFIFGYVEDKIGSKRAILItLYLLIFSTLIAFFAPY-TSSPKI------TFWISAILLGLMVGPNQSSSRSL 338
Cdd:pfam11700 328 AMIAAVLGAFLWPFVSRRFNLKTKQTL-IACIVLFELIPLYGLLgIILGKIglknpwEFWVLQAFYGLVLGGLRSYSRSL 406
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 330752538 339 LSKIIPANKKNEFYGFFALTGKATSFVGPLLFGIIS-ANFSQQIALWIVILLFCIGTIIFKNICFDKG 405
Cdd:pfam11700 407 YSELIPRGKEAQFFSLYAITDKGSSWIGPLIVGAIQdRTGNIRSPFVFLAILLVVPLPLLLLVDVERG 474
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
65-397 |
3.51e-20 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 91.89 E-value: 3.51e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 65 PILGALADRNSS----RKLMLIITTYISIIFIGLLYFPEKGDIMFSLIFFAIANVAFELS-TVF---YNSFLPDLSNNQN 136
Cdd:COG2211 64 PLIGALSDRTRTrwgrRRPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAyTLVnipYSALGAELTPDYE 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 137 S-GKISGNAWGFGFVGGLISLFICLSMFDVNQSSEIPKVsLLVAIWFFIFSVPAFIFLKEKKKLVTKKLSTLNQLKSTFK 215
Cdd:COG2211 144 ErTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGY-RLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLK 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 216 SIKEYKSIFKFFIARLFYNDALITIFSLGGIYAVGTVGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRAILITLY 295
Cdd:COG2211 223 ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 296 LLIFSTLIAFFAPYTSSPkiTFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNE-------FYGFFALTGKATSFVGPL 368
Cdd:COG2211 303 LAALGLLLLFFLGPGNLW--LLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIFTFAIKLGQALAGA 380
|
330 340 350
....*....|....*....|....*....|....*..
gi 330752538 369 LFGIISANF--------SQQIALWIVILLFCIGTIIF 397
Cdd:COG2211 381 LAGLLLALFgyvagaaqSPSALTGIRLLFFLLPAVLL 417
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
65-397 |
5.89e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 66.45 E-value: 5.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 65 PILGALADRNSSRKLMLIITtyiSIIFIGLLYFPEKGDIMFSLIFFAIANVAFELSTVFYNSFLPDLSNNQNSGKISGNA 144
Cdd:cd17325 49 PPAGRLSDRFGRKRLLLLGL---LLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIF 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 145 WGFGFVGGLISLFICLSMFDVnqsSEIPKVSLLVAIWFFIFSVPAFIFLKEKKKLVTKKLSTLNQLKSTFKSIKEYKSIF 224
Cdd:cd17325 126 SSAIGLGFLIGPLLGGLLADA---LGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLL 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 225 KFFIARLFYNDALITIFSLGGIYAVGTVGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRAILITlylLIFSTLIA 304
Cdd:cd17325 203 ALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG---LLLSAVAL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 305 FFAPYTSSPkITFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEFYGFFALTGKATSFVGPLLFGIISANFSQQIALW 384
Cdd:cd17325 280 LLLPLATSF-WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
330
....*....|...
gi 330752538 385 IVILLFCIGTIIF 397
Cdd:cd17325 359 AAAALLLLAAVLF 371
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
182-397 |
5.67e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 63.33 E-value: 5.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 182 FFIFSVPAFIFLKEKKKLVTKKLSTLNQLKSTFK-SIKEYKSIFKFFIARLF------YNDALItifslggIYAVGTVGF 254
Cdd:cd17370 159 FLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKtSLKKLPKAFWLYLLAVAlfalgnFSFAFL-------ILRAQELGL 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 255 ELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFFapytSSPKITFWISAILLGLMVGPNQSS 334
Cdd:cd17370 232 SAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFAL----GSSLWLLLLGFILWGLYMGAQESI 307
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 330752538 335 SRSLLSKIIPANKKNEFYGFFALTGKATSFVGPLLFGIISANFSQQIALWIVILLFCIGTIIF 397
Cdd:cd17370 308 ERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-397 |
2.42e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 61.67 E-value: 2.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 21 FSTIIVTFIYSAFFTTYIVEDVDKGTLLWTrVISISAIIAAILSPILGALADRnSSRKLMLIITTYISIIFIGLLYFPEK 100
Cdd:cd06174 6 FLTGLARGLISPLLPALLQSFGLSASQLGL-LFALFSLGYALLQPLAGLLADR-FGRRPVLLLGLLLFALGALLFAFAPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 101 GDIMfsLIFFAIANVAFELSTVFYNSFLPDLSNNQNSGKISGNAWGFGFVGGLISLFICLSMFDVNQSSeIPKVSLLVAI 180
Cdd:cd06174 84 FWLL--LLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFG-WRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 181 WFFIFSVPAFIFLKEKKKLVTKKLSTLNQ--LKSTFKSIKEYKSIFKFFIARLFYNDALITIFSLGGIYAVGTVGFELSE 258
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSksVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 259 VFILGIFLNISAAIGSFIFGYVEDKIGSKRAILitlYLLIFSTLIAFFAPYTSSPKITFWISAILLGLMVGPNQSSSRSL 338
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL---LIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 330752538 339 LSKIIPANKKNEFYGFFALTGKATSFVGPLLFGIISANFSQQIALWIVILLFCIGTIIF 397
Cdd:cd06174 318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
226-397 |
1.24e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 59.50 E-value: 1.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 226 FFIARLFYNDALITIFSLGGIYAVGTVGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRAILITLYLLIfsTLIAF 305
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLL--AALAL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 306 FAPYTSSPKITFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEFYGFFALTGKATSFVGPLLFGIISANFSQQIALWI 385
Cdd:COG2271 263 LLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLL 342
|
170
....*....|..
gi 330752538 386 VILLFCIGTIIF 397
Cdd:COG2271 343 LAALALLAALLA 354
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
65-373 |
1.63e-08 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 56.07 E-value: 1.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 65 PILGALADRNSSRK-----LMLIITTYISIIFIgLLYFPEKGDIMFSLIFFAIANVAFELS----TVFYNSFLPDLSNNQ 135
Cdd:cd17332 53 PLMGYLIDRTRSRWgrfrpWLLWGAIPLALLFV-LLFTTPDGSGTGKLIYALITYILLDLLytlvNIPYTALIPELTDDP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 136 NS-GKISGNAWGFGFVGGLISLFICLSMFDVNQSSEIPKVSLLVAIWFFIFSVPAFIFLKEKK---KLVTKKLSTLNQLK 211
Cdd:cd17332 132 EErTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGTrerVVPPEEEKSKLPLL 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 212 STFKSIKEYKSIFKFFIARLFYNDALITIFSLGGIYAVGTVGFELSEVFILGIFLnISAAIGSFIFGYVEDKIGSKRAIL 291
Cdd:cd17332 212 KSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLIL-SGALLALLPWPPLKKRFGKKKAFF 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 292 ITLYLLIFSTLIAFFAPYTSSpkITFWISAILLGLMVGPNQSSSRSLLSKII-----PANKKNE--FYGFFALTGKATSF 364
Cdd:cd17332 291 IGLLLAILGLLLLFFLPPGNL--VLILVLAVLAGIGYGGANLLPWAMLADVIdygelKTGKRREgiFYSVMTFFRKLGLA 368
|
....*....
gi 330752538 365 VGPLLFGII 373
Cdd:cd17332 369 LAGALVGLI 377
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
65-392 |
8.82e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 53.70 E-value: 8.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 65 PILGALADRNSSRKLMLIITTYISIIFIGLLYFPEKGDIMFSLIFFAIANVAFELSTvfyNSFLPDLSNNQNSGKISGN- 143
Cdd:COG0738 61 LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAA---NPYVAALGPETAASRLNLLh 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 144 -AWGFG-FVGGLISLFICLSMFDvnqsseiPKVSLLVAIWFFIFSVPAFIFLKEKKKLVTKKLSTLNQLKSTFKSIKEYK 221
Cdd:COG0738 138 aFFSLGaLLGPLLGGLLILLGLS-------LSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNP 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 222 SIFKFFIARLFYNDALITIFSLGGIYAVGTVGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRAILITLYLLIFST 301
Cdd:COG0738 211 RLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGL 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 302 LIAFFAPYTsspkITFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEFyGFFALTGKATSFVGPLLFGIISANFSQQI 381
Cdd:COG0738 291 LLALLAPGP----WLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAFGLRA 365
|
330
....*....|.
gi 330752538 382 ALWIVILLFCI 392
Cdd:COG0738 366 AFLVPLVCYLL 376
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
65-396 |
9.16e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 53.73 E-value: 9.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 65 PILGALADRNSSRKLMLIITTYISIIFIGLLYFPEKGDIMFSLIFFAIANVAFELSTVFYNS--FLPDlsnnqNSGKISG 142
Cdd:COG2223 58 IPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSkwFPPD-----RRGLALG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 143 NAWGFGFVGGLISLFICLSMFDvnqSSEIPKVSLLVAIWFFIFSVPAFIFLKEK-KKLVTKKLSTLNQLKSTFKSikeyK 221
Cdd:COG2223 133 LAAGGGNLGAAVAAFLAPLLIA---AFGWRNAFLILGILLLVVAVLAWLFLRDPpAGAAAAAKASLRDQLEALRD----P 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 222 SIFKFFIARLFYNDALITIFSLGGIYAVGTVGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRAILItlyLLIFST 301
Cdd:COG2223 206 RFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLI---VFALMA 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 302 LIAFFAPYTSSPKITFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEFYGFFALTGKATSFVGPLLFGIISANF-SQQ 380
Cdd:COG2223 283 LGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYT 362
|
330
....*....|....*.
gi 330752538 381 IALWIVILLFCIGTII 396
Cdd:COG2223 363 AAFLVFAVLALVALVL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
65-359 |
3.96e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.51 E-value: 3.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 65 PILGALADRNSSRKLMLIITTYISIIFIGLLYFPekgDIMFSLIFFAIANVAFELSTVFYNSFLPDLSNNQNSGKISGN- 143
Cdd:COG2814 63 PLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP---SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLl 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 144 --AWGFGFVGGLISLFICLSMFDVNQSSEIPKVSLLVAIWFFIFSVPAfiflkekkklvtKKLSTLNQLKSTFKSIKEYK 221
Cdd:COG2814 140 gaGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPE------------SRPAARARLRGSLRELLRRP 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 222 SIFKFFIARLFYNDALITIFSLGGIYAVGTVGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRAILITLYLLIFST 301
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL 287
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 330752538 302 LIAFFAPYTsspkITFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEFYGFFALTG 359
Cdd:COG2814 288 LLLALAGSL----WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
236-397 |
5.14e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.13 E-value: 5.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 236 ALITIFSLGGIYAVGTVGFELSEVF---------ILGIFLnISAAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFF 306
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADLgaspaqaglVVTAYL-LGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 307 APytsSPkITFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEFYGFFALTGKATSFVGPLLFGIISANFSQQIALWIV 386
Cdd:COG2814 95 AP---SL-WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
170
....*....|.
gi 330752538 387 ILLFCIGTIIF 397
Cdd:COG2814 171 AVLALLALLLL 181
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
236-397 |
5.70e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 51.03 E-value: 5.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 236 ALITIFSLGGIYAVGTVGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFFAPytssPKI 315
Cdd:COG2223 19 GVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV----SYW 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 316 TFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEFYGFFALTGKATSFVGPLLFGIISANFSQQIALWIVILLFCIGTI 395
Cdd:COG2223 95 LLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAV 174
|
..
gi 330752538 396 IF 397
Cdd:COG2223 175 LA 176
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
268-396 |
2.55e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 48.65 E-value: 2.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 268 ISAAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFFAPYTsspkITFWISAILLGLMVGPNQSSSRSLLSKIIPANK 347
Cdd:COG0477 60 LGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSP----ELLIAARALQGIGAGGLMPGALALIAELFPARE 135
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 330752538 348 KNEFYGFFALTGKATSFVGPLLFGIISANFSQQIALWIVILLFCIGTII 396
Cdd:COG0477 136 RGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVL 184
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
21-367 |
1.08e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.03 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 21 FSTIIVTFIYSAFFTTYIVEDVDKGTLLWTRVISISAIIAAILSPILGALADRNSSRKLMLIITTYISIIFIGLLYFPEK 100
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 101 GDIMFSLIFFAIANVAFelsTVFYNSFLPDLSNNQNSGKISGNAWGFGFVGGLISLFICLSMFDvnqSSEIPKVSLLVAI 180
Cdd:pfam07690 86 WLLLVLRVLQGLGAGAL---FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS---LFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 181 WFFIFSVPAFIFLKEKKKLVTKKLSTLNQLKSTFKSIKEYKSIFKFFIARLFYNDALITIFSLGGIYAVgTVGFELSEVF 260
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE-VLGLSALLAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 261 ILGIFLNISAAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFFAPYTSSPkITFWISAILLGLMVGPNQSSSRSLLS 340
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSS-LWLLLALLLLGFGFGLVFPALNALVS 317
|
330 340
....*....|....*....|....*..
gi 330752538 341 KIIPANKKNEFYGFFALTGKATSFVGP 367
Cdd:pfam07690 318 DLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
226-397 |
1.86e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 46.26 E-value: 1.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 226 FFIARLFYNDALITIFSLGGIYAVGTVGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAF 305
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 306 FApytsSPKITFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEFYGFFALTGKATSFVGPLLFGIISANFSQQIALWI 385
Cdd:pfam07690 81 FA----SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170
....*....|..
gi 330752538 386 VILLFCIGTIIF 397
Cdd:pfam07690 157 LAILSLLAAVLL 168
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
260-396 |
3.25e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.63 E-value: 3.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 260 FILGIFLnISAAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFFAPYTsspkITFWISAILLGLMVGPNQSSSRSLL 339
Cdd:COG2271 49 LLASAFF-LGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSF----WQLLLLRFLLGLGEAGFFPAALKLI 123
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 330752538 340 SKIIPANKKNEFYGFFALTGKATSFVGPLLFGIISANFSQQIALWIVILLFCIGTII 396
Cdd:COG2271 124 AEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL 180
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
67-396 |
4.65e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 45.29 E-value: 4.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 67 LGALADRNSSRKLMLIITTYISII-FIGLLYFPEKGDIMFSLIFFAIANVAFELSTVFYNSFLPdlsnNQNSGKISGNAW 145
Cdd:cd17490 51 LGILSDRIGKRKLFIIIGLLFTVLaSLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASYFP----PDEAAKAMGLIN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 146 GFGFVGGLISLFICLSMFDvnqsseipKVSLLVAIWF-FIFSVPAFIFLKEKKKLVTKKLSTLNQLKSTFKSIKEYKSIF 224
Cdd:cd17490 127 LVNNLGQLIAFLIGGLIAE--------HFGMRAPFLLaALAGVLGFILSLFIKEERREKKPVLTELKELLSVLKDKKLLF 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 225 KFFIARLFYNDALITIFSLGGIYA--VGTVGFELSevfILGIFLNISAAIGSFIFG-YVEDKIGSKRAILITLYLLifsT 301
Cdd:cd17490 199 FSLLAILQQMITFSTTFGFTPLIAkqLGASSFQLG---LLSIIYLLPNALASLLSGtLFYKKLGERNTIIIGFLLL---G 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 302 LIAFFAPYTSSPkITFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEFYGFFALTGKATSFVGPLLFGIISANFSQQI 381
Cdd:cd17490 273 AYCFLIPFAPNL-TLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQT 351
|
330
....*....|....*
gi 330752538 382 ALWIVILLFCIGTII 396
Cdd:cd17490 352 GFFVIGVIALLAAIL 366
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
65-377 |
3.16e-04 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 42.68 E-value: 3.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 65 PILGALADRNSSR-----KLMLIITTYISIIFIGLLYFPEKGDI---MFSLIFFAIANVAFELSTVFYNSFLPDLS-NNQ 135
Cdd:pfam13347 51 PIVGHIIDRTRTRwgrrrPWLLLSAIILAVSFILLFTPPELGRAplfIWLLATYILLRIAYTFFEIPYWSLGPELTrDYD 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 136 NSGKISGNAWGFGFVGGLISLFICLSMFDVNQSSEIPKVSLLVAIWFF-IFSVPAFIFLKEKKKLVTKK----------- 203
Cdd:pfam13347 131 ERTSLTSYRSFFSVGGGLLAAALAFPLVLILGGTGLERKGYRIFALIGaVLMLLGVIITAAGTKERVSMrskedtgqkea 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 204 LSTLNQLKSTFKSiKEYKSIFKFFIARLFyndALITIFSLGGIYAVGTVGFElSEVFILGIFLNISAAIGSFIFGYVEDK 283
Cdd:pfam13347 211 GSLLDMLKEVFRN-RAFLILLASFLLAAL---AMGVLNGLLLYYFRYVLGNG-FAASAFPLVFTIGALLGIPLWPPLAKR 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 284 IGSKRAILITLYLLIFSTLIAFFAPYTSSpkITFWISAILLGLMVGPNQSSSRSLLSKIIPAN-----KKNE--FYGFFA 356
Cdd:pfam13347 286 IGKKNTYILGALITIAGFALALLLGPNNT--LLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGelrtgKRREgtFFAMWS 363
|
330 340
....*....|....*....|.
gi 330752538 357 LTGKATSFVGPLLFGIISANF 377
Cdd:pfam13347 364 FISKLATGVGLGVSGLLLSAF 384
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
209-395 |
4.06e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 42.25 E-value: 4.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 209 QLKSTFKSIKEYKSIFKFFIARLFYNDALITIFSLGGIYAVGTVGFELSEVFILGIFLN---ISAAIGSFIFGYVEDKIG 285
Cdd:cd17391 189 STKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSatgVSSLLSAPRLGKLGDRIG 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 286 SKRAILITLyllIFSTLIAFFAPYTSSPKITFWISaILLGLMVGPNQSSSRSLLSKIIPANKKNEFYGFFALTGKATSFV 365
Cdd:cd17391 269 HHRILLGAL---LASALLYIPQAFVQTPWQLGILR-FLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVA 344
|
170 180 190
....*....|....*....|....*....|
gi 330752538 366 GPLLFGIISANFSQQIALWIVILLFCIGTI 395
Cdd:cd17391 345 GPLLGSAIAAHFGYRAVFVVTALLVLLNAI 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
237-373 |
4.24e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 42.34 E-value: 4.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 237 LITIFSLGGIYAVGT--------VGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFFAp 308
Cdd:TIGR00895 257 LLYFMLLVGVYFLTNwlpklmveLGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTL- 335
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 330752538 309 ytSSPKItFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEFYGFFALTGKATSFVGPLLFGII 373
Cdd:TIGR00895 336 --FSPTL-LLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
231-330 |
8.91e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 41.36 E-value: 8.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 231 LFYndaLITIFSLGgiYAVGTVGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFFAPYT 310
Cdd:cd17369 243 LFY---LFTTFALS--YATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDT 317
|
90 100
....*....|....*....|....
gi 330752538 311 SSPKITFW----ISAILLGLMVGP 330
Cdd:cd17369 318 GSTWLIVLaavvVLGVLHGMMYGP 341
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
265-396 |
9.11e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.01 E-value: 9.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 265 FLNISAAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFFAPYTSSPkitfWISAILLGLMVGPNQSSSRSLLSKIIP 344
Cdd:COG2807 258 LFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLP----WLWAVLLGLGQGGLFPLALTLIGLRAR 333
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 330752538 345 ANKKN-EFYGFFALTGKATSFVGPLLFGII---SANFsqQIALWIVILLFCIGTII 396
Cdd:COG2807 334 TPAEAaALSGMAQSVGYLLAALGPLLVGALhdaTGSW--TAALLLLAALAVLMLVA 387
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
236-378 |
1.11e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 40.65 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 236 ALITIFSLGGIYAVGT--------VGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRAILITlYLLIFSTLIAFFA 307
Cdd:cd17365 177 WVTFFMGLLLVYLLNSwlpklmveAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALF-FALGAVSLALLGV 255
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 330752538 308 PYTSSPkiTFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEFYGFFALTGKATSFVGPLLFG-IISANFS 378
Cdd:cd17365 256 SPASLV--LLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGlLLAAGLG 325
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
259-389 |
1.39e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 40.74 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 259 VFILGIFLNisaAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFFAPytSSPKITFWISAILL------GLMVGPNQ 332
Cdd:cd17367 45 VFAVGFLMR---PIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTP--TYATIGIWAPIILLlarllqGLSVGGEY 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 330752538 333 SSSRSLLSKIIPANKKnefyGFFAltgkatsfvgplLFGIISANFSQQIALWIVILL 389
Cdd:cd17367 120 GTSATYLSEVAPPGRR----GFYS------------SFQYVTLIGGQLLALGVLLVL 160
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
235-400 |
1.55e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.28 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 235 DALITIFSLGGIYAVGTVGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFFAPYTsspk 314
Cdd:cd17316 14 DFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP---- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 315 ITFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEF----YGFFALTGKATSFVGPLLFGIISANFSQQIALWIVILLF 390
Cdd:cd17316 90 ILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFAlgllQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPA 169
|
170
....*....|
gi 330752538 391 CIGTIIFKNI 400
Cdd:cd17316 170 LLALLLRRRT 179
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
65-397 |
2.05e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.91 E-value: 2.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 65 PILGALADRNSSRKLMLIITTYISIIFIGLLYFPEKGDIMFSLIFFA--IANVAFELSTVFYNSFLPDLSNNQNSGKisG 142
Cdd:cd06173 52 PFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLafLLGIASAFFGPARQALLPELVPKEQLVR--A 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 143 NAW-----------GFGFVGGLISLFiclsmfdvnqsseIPKVSLLVAIWFFIFSVPA--FIFLKEKKKLVTKKLSTLNQ 209
Cdd:cd06173 130 NALnslatqlariiGPALGGLLVALL-------------GPGGAFAINALSFLLSALLllFIRRPPPAAPGESSSLLLRD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 210 LKSTFKSIKEYKSIFKFFIARLFYNDALITIFSLGGIYAVGTVGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRA 289
Cdd:cd06173 197 LREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 290 ILITLYLLIFSTLIAFFAPYTsspkITFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEFYGFFALTGKATSFVGPLL 369
Cdd:cd06173 277 LLIGALLLGLALLVLGLSPSL----WLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALL 352
|
330 340
....*....|....*....|....*...
gi 330752538 370 FGIISANFSQQIALWIVILLFCIGTIIF 397
Cdd:cd06173 353 AGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
221-397 |
2.93e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.48 E-value: 2.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 221 KSIFKFFIARLFYNDALITIFSLGGIYAVGTVGFELSEVFILGIFLNISAAIGS-FIFGYVEDKIGSKRAILITLYLLIF 299
Cdd:cd17330 174 PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAII 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 300 STLIAFFAPYTSspkiTFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEFYGFFALTGKATSFVGPLLFGIISANFSQ 379
Cdd:cd17330 254 GLLLLPFASSVP----LLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGP 329
|
170
....*....|....*...
gi 330752538 380 QIALWIVILLFCIGTIIF 397
Cdd:cd17330 330 GVPFLLAAGLLLIALFLL 347
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
260-397 |
4.51e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.08 E-value: 4.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 260 FILGIFLnISAAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFFAPYTSSpkitfWISAILLGLMVGPNQSSSRSLL 339
Cdd:cd17478 234 LLLSLFL-FAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWS-----YILLVLAGFLLFASFPVTVVLA 307
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 330752538 340 SKIIPANK---KNEFYGF-FALTGkatsfVGPLLFGIISANFSQQIALWIVILLFCIGTIIF 397
Cdd:cd17478 308 QELLPGNVglaSGLMMGLsFGLGG-----IGAPVLGALADAFGLESVLLILALLPLLGALLA 364
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
235-388 |
5.04e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.82 E-value: 5.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 235 DALITIFSLGGIYAvgTVGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFFAPytsspk 314
Cdd:cd17371 14 DLLLLGLVLPALIA--EFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ------ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 315 iTFWISAI---LLGLMVGPNQSSSRSLLSKIIPANKKNEFYG----FFALTGKATSFVGPLLFGIISANFSQQIALWIVI 387
Cdd:cd17371 86 -NYWQLLIlraLAGLGFGGEWAAGAALMAEYVPARHRGKALGyvqsGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGA 164
|
.
gi 330752538 388 L 388
Cdd:cd17371 165 L 165
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
272-402 |
5.17e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 38.89 E-value: 5.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 272 IGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFFAPytSSPKITFWISAILL------GLMVGPNQSSSRSLLSKIIPA 345
Cdd:cd17368 55 IGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAP--TYATIGIAAPLLVLlarllqGFAAGGEVGGVTAYLVEAAPP 132
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 330752538 346 NKKNeFYGFFALTGKATS-FVGPLLFGIISANFSQ-QIALWIVILLFCIGTIIFKNICF 402
Cdd:cd17368 133 GRRG-FYTSWQSASQQVAiVAGALVGYLLSLTLTAeALAEWGWRIPFFIGLLIIPLGLW 190
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
65-396 |
5.27e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 5.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 65 PILGALADRNSSRKLMLI---------ITTYISIIFIGLLYFpekgdimFSLIFFAIANVAFELSTVFYNSFLPDlsnnq 135
Cdd:cd17353 56 PFAGRLVDRGGPRKAILIggilfglgfILSAFAISLPLLFLG-------YGVLGGIGAGIGYITPVSTAVKWFPD----- 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 136 NSGKISG-NAWGFGFvGGLISLFICLSMFDvnqSSEIPKVSLLVAIWFFIFSVPAFIFLKEKKKLVTKKLSTLNQLKSTF 214
Cdd:cd17353 124 KRGLATGiVIAGFGL-GSLIFSPLIAYLIN---TVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAEN 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 215 KSIKEY-------KSIFKFFIARLFYNDALITIFSLGGIYAVGTVGFELSEVFILGIFLNISAAIGSFIFGYVEDKIGSK 287
Cdd:cd17353 200 SPRDYTpremlrtPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRK 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 288 RAILItlyLLIFSTLIAFFAPYTSSPKITFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEFYGFFaLTGKATS-FVG 366
Cdd:cd17353 280 NTLSI---AFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLL-YTAKGVGgLIG 355
|
330 340 350
....*....|....*....|....*....|
gi 330752538 367 PLLFGIISANFSQQIALWIVILLFCIGTII 396
Cdd:cd17353 356 PIIAAYVLYTGGYNAAFIIAAALSLVALAL 385
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
65-397 |
5.94e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 38.71 E-value: 5.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 65 PILGALADRnSSRKLMLIITTYISIIFIGLLYFpeKGDIMFSLIFFAIANVAFELSTVFYNSFLPDLSNNQNSGKIsgna 144
Cdd:cd17474 52 PVAGVLADR-FGRKKVLLPGLLLFGIGGLLCGL--SDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKA---- 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 145 wgFGFVGGLISLFICLSmfdvnqsseiPKV-SLLVAI-WFFIFSVPAFIFLKEKKKLVTKKLSTLN-QLKSTFKSIKEYK 221
Cdd:cd17474 125 --MGLYEAALGLGIAVG----------PLLgGLLAAIsWRYPFFLLAALIPVAFLAILFLLPEPKEkAKSSSATKLRDLK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 222 SIFKFFIARLFYNDALITIFSLGGIYA----VGTVGFELSEVFILGIFLNISA--AIGSFIFGY-VEDKIGSKRAILITL 294
Cdd:cd17474 193 KALRGRGLLTFLVSAFLYFFLYFAFLTylpfLLELLYGISPIIIGLLFAGWSVllALGSLFVGRlLKKRFGARRILVIGL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 295 YLLIFSTLIAFFAPytssPKITFWISAILLGLMVGPNQSSSRSLLSKIIPANKKNEF---YGFFALTGKAtsfVGPLLFG 371
Cdd:cd17474 273 LLYALSLLLLGFVP----SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTAsslYNFVRFLGQA---VGPLLFG 345
|
330 340
....*....|....*....|....*.
gi 330752538 372 IISANFSQQIALWIVILLFCIGTIIF 397
Cdd:cd17474 346 LLLEIFGLSAPFLVGAAIALAAAVLL 371
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
268-347 |
9.20e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 37.93 E-value: 9.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330752538 268 ISAAIGSFIFGYVEDKIGSKRAILITLYLLIFSTLIAFFAPYTSspkiTFWISAILLGLMVGPNQSSSRSLLSKIIPANK 347
Cdd:cd17359 47 LGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFT----IFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
|
| |
