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Conserved domains on  [gi|291516422|emb|CBK70038|]
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carbohydrate ABC transporter membrane protein 2, CUT1 family (TC 3.A.1.1.-) [Bifidobacterium longum subsp. longum F8]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 11417684)

carbohydrate ABC transporter permease, part of a periplasmic binding protein (PBP)-dependent ABC transporter may be involved in transport of one or more of a variety of mono-, di-, or polysaccharides, such as trehalose/maltose (MalG) and alginate (AlgM); responsible for translocation of the substrate across the membrane

Gene Ontology:  GO:0055085|GO:0008643
PubMed:  19234479|27273632
TCDB:  3.A.1.1.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 39-319 8.24e-83

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 251.55  E-value: 8.24e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422  39 SALVKTITIVVLVFALIYFLFPIYWAIIASTKTPSQMTGSNGLWFAVGLSdlpaaiAKNYGTLigWTRGQFWRWVLNSLI 118
Cdd:COG0395   10 RRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLLPSEFT------LENYRAA--FTDGPFGRYLLNSLI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 119 YSGVSALVGTLVAVMAGYATAKFNFKGKNLAIGVIMGCMLMPAALLTIPQYSIFHAMHLTNTMLSIIIPCCV--SPFGFF 196
Cdd:COG0395   82 VAVVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAfgLPFGIF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 197 LGRVYAQtSVPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVATWNNFLLPLMMVSSDTLKPVTLGLYGMVS 276
Cdd:COG0395  162 LLRQFFR-SIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQG 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 291516422 277 LATfTDRGALMMGALLGVLPVIVLFLGLQRYWQAGLAAGAVKG 319
Cdd:COG0395  241 QYG-TDWGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVKG 282
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 39-319 8.24e-83

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 251.55  E-value: 8.24e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422  39 SALVKTITIVVLVFALIYFLFPIYWAIIASTKTPSQMTGSNGLWFAVGLSdlpaaiAKNYGTLigWTRGQFWRWVLNSLI 118
Cdd:COG0395   10 RRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLLPSEFT------LENYRAA--FTDGPFGRYLLNSLI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 119 YSGVSALVGTLVAVMAGYATAKFNFKGKNLAIGVIMGCMLMPAALLTIPQYSIFHAMHLTNTMLSIIIPCCV--SPFGFF 196
Cdd:COG0395   82 VAVVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAfgLPFGIF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 197 LGRVYAQtSVPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVATWNNFLLPLMMVSSDTLKPVTLGLYGMVS 276
Cdd:COG0395  162 LLRQFFR-SIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQG 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 291516422 277 LATfTDRGALMMGALLGVLPVIVLFLGLQRYWQAGLAAGAVKG 319
Cdd:COG0395  241 QYG-TDWGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVKG 282
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
48-312 1.37e-29

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 114.06  E-value: 1.37e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422  48 VVLVFALIYFLFPIYWAIIASTKTPSQMtgsnglwFAVGLSDLPAA-----IAKNYGTLIGWTRGQFWRWVLNSLIYSGV 122
Cdd:PRK10973  14 TMLILGIAVILFPLYVAFVAATLDKQAV-------FAVPMTLIPGThllenIANIWVNGVGNNSAPFGRMLLNSFVMAFS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 123 SALVGTLVAVMAGYATAKFNFKGKNLAIGVIMGCMLMPAALLTIPQYSIFHAMHLTNTMLSIIIPCCVSPFGFFLGRVYA 202
Cdd:PRK10973  87 ITVGKITVSMLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLPLMASATATFLFRQFF 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 203 QTsVPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVATWNNFLLPLMMVSSDTLKPVTLGLYGMVSLATFTD 282
Cdd:PRK10973 167 MT-LPDELVEAARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLIITDVSLGTAVAGIKGMIATGEGTT 245

                        250       260       270
                 ....*....|....*....|....*....|.
gi 291516422 283 RGALMMGA-LLGVLPVIVLFLGLQRYWQAGL 312
Cdd:PRK10973 246 EWNQVMAAmLLTLIPPVVIVLAMQRAFVRGL 276
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 114-298 6.58e-14

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 68.84  E-value: 6.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 114 LNSLIYSGVSALVGTLVAVMAGYATAKFNFKGKNLAIGVIMGCMLMPAALLTIPQYSIFHAMHLTNTMLSIIIPCCVSPF 193
Cdd:cd06261    2 LNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALILAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 194 GFFLG-----RVYAQTSVPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVATWNNFLLPLMMVSSDTLKPvT 268
Cdd:cd06261   82 LLIAPfarliRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGP-G 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 291516422 269 LGLYGMVSLATFTDRGALMMGALLGVLPVI 298
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 127-307 1.09e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 56.92  E-value: 1.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422  127 GTLVAVMAGYataKFNFKGKNLAIGVIMGCMLMPAALLTIPQYSIFHAMHLTNTMLSIIIPCCVSPFGFFLG-RVYAQTS 205
Cdd:pfam00528   1 GIPLGIIAAL---RRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLiRRAALRS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422  206 VPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVATWNNFLLPLMMVSSDTL-KPVTLGLYGMVslatFTDRG 284
Cdd:pfam00528  78 LPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLgLLLIEAILGYD----YPEIQ 153

                         170       180
                  ....*....|....*....|...
gi 291516422  285 ALMMGALLGVLPVIVLFLGLQRY 307
Cdd:pfam00528 154 GPVLAAALILLLLNLLVDILQRL 176
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 39-319 8.24e-83

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 251.55  E-value: 8.24e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422  39 SALVKTITIVVLVFALIYFLFPIYWAIIASTKTPSQMTGSNGLWFAVGLSdlpaaiAKNYGTLigWTRGQFWRWVLNSLI 118
Cdd:COG0395   10 RRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLLPSEFT------LENYRAA--FTDGPFGRYLLNSLI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 119 YSGVSALVGTLVAVMAGYATAKFNFKGKNLAIGVIMGCMLMPAALLTIPQYSIFHAMHLTNTMLSIIIPCCV--SPFGFF 196
Cdd:COG0395   82 VAVVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAfgLPFGIF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 197 LGRVYAQtSVPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVATWNNFLLPLMMVSSDTLKPVTLGLYGMVS 276
Cdd:COG0395  162 LLRQFFR-SIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQG 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 291516422 277 LATfTDRGALMMGALLGVLPVIVLFLGLQRYWQAGLAAGAVKG 319
Cdd:COG0395  241 QYG-TDWGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVKG 282
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 43-319 1.14e-54

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 179.58  E-value: 1.14e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422  43 KTITIVVLVFALIYFLFPIYWAIIAStktpsqMTGSNGLwfaVGLSDLPAAIA-KNYGTLIgwTRGQFWRWVLNSLIYSG 121
Cdd:COG3833   15 LGLRHLVLIILAIIALFPILWVVSAS------FNPGGSL---YSSSLIPENFTlENYKKLF--TETPFLRWFLNSLIVAV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 122 VSALVGTLVAVMAGYATAKFNFKGKNLAIGVIMGCMLMPAALLTIPQYSIFHAMHLTNTMLSIIIPCCVS--PFGFFLGR 199
Cdd:COG3833   84 VTAIISVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAFLALVALYLLLSALGLLNTLLGLILVYLGGaiPFNTWLMK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 200 VYAQTsVPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVATWNNFLLPLMMVSSDTLKPVTLGLYGMVSLAT 279
Cdd:COG3833  164 GYFDT-IPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSFVSDQR 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 291516422 280 FTDRGALMMGALLGVLPVIVLFLGLQRYWQAGLAAGAVKG 319
Cdd:COG3833  243 NTNWGVFAAGAVLVAIPIVILFLFLQRYLVSGLTAGGVKG 282
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
48-312 1.37e-29

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 114.06  E-value: 1.37e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422  48 VVLVFALIYFLFPIYWAIIASTKTPSQMtgsnglwFAVGLSDLPAA-----IAKNYGTLIGWTRGQFWRWVLNSLIYSGV 122
Cdd:PRK10973  14 TMLILGIAVILFPLYVAFVAATLDKQAV-------FAVPMTLIPGThllenIANIWVNGVGNNSAPFGRMLLNSFVMAFS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 123 SALVGTLVAVMAGYATAKFNFKGKNLAIGVIMGCMLMPAALLTIPQYSIFHAMHLTNTMLSIIIPCCVSPFGFFLGRVYA 202
Cdd:PRK10973  87 ITVGKITVSMLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLPLMASATATFLFRQFF 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 203 QTsVPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVATWNNFLLPLMMVSSDTLKPVTLGLYGMVSLATFTD 282
Cdd:PRK10973 167 MT-LPDELVEAARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLIITDVSLGTAVAGIKGMIATGEGTT 245

                        250       260       270
                 ....*....|....*....|....*....|.
gi 291516422 283 RGALMMGA-LLGVLPVIVLFLGLQRYWQAGL 312
Cdd:PRK10973 246 EWNQVMAAmLLTLIPPVVIVLAMQRAFVRGL 276
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 39-307 1.82e-20

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 88.63  E-value: 1.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422  39 SALVKTITIVVLVFALIYFLFPIYWAIIASTKTPSQMTGsngLWFAVGLsdlpaaiaKNYGTLigWTRGQFWRWVLNSLI 118
Cdd:COG1177    2 SRLGRLLLRLFLALVLLFLYLPILVLVLYSFNDSWFLTF---PPEGFTL--------RWYAEL--FSDPRLLDALLNSLL 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 119 YSGVSALVGTLVAVMAGYATAKFNFKGKNLAIGVIMGCMLMPAALLTIPQYSIFHAMHLTNTMLSIIIPCCV--SPFGFF 196
Cdd:COG1177   69 IALLSTLLATVLGTPAALALARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLFSALGLSGGLWGLILAHVVftLPFVVL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 197 LgrVYAQ-TSVPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVATWNNFLLPLMMVSSDTlKPVTLGLYGMV 275
Cdd:COG1177  149 V--VLARlQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFTLSFDEFVITLFLAGPGV-TTLPVYIYSMI 225

                        250       260       270
                 ....*....|....*....|....*....|..
gi 291516422 276 SLATFTDRGALmmgALLGVLPVIVLFLGLQRY 307
Cdd:COG1177  226 RRGISPEINAL---STLLILLSLLLLLLAERL 254
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
15-306 7.36e-15

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 74.81  E-value: 7.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422  15 ARARKKADRIRDKHANDLPRSMQPSALVKTITIVVLVFALIYFLFPIYWAIIASTKTPSQMTGSNGLWFAVglsdlpaai 94
Cdd:COG1178  260 RRLRRRRRYATVGGRARRPRRVKLGRWRWLALALCLLLVLLGLLLPLLALLLWSLTKALDDNLTLDNYRFV--------- 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422  95 aknygtligWTRGQFWRWVLNSLIYSGVSALVGTLVAVMAGYATAKFNFKGKNLAIGVIMGCMLMPA-----ALLTIpqY 169
Cdd:COG1178  331 ---------LLDPSLLRALLNSLLLALLAALLAVLLALLLAYLVRRRRGRLARLLDRLAMLPYAVPGivlglGLLLL--F 399

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 170 SIFHAMHLTNTMLSIIIPCCV--SPFGFFLGRVyAQTSVPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVA 247
Cdd:COG1178  400 NRPLPLLLYGTLAILVLAYVVrfLPFALRSLEA-ALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVT 478

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 248 TWNNFLLPLMMVSSDTlKPVTLGLYGMVSLATFTDRGAL-MMGALLGVLPVIVLFLGLQR 306
Cdd:COG1178  479 SMKELSATLLLRPPGF-ETLAVLIYQLASSGRYGEAAALaLLLVLVSLLPVLLLERLLGR 537
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
50-258 2.99e-14

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 71.70  E-value: 2.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422  50 LVFALIYFLFPIYWAIIASTkTPSQMTGSNGLWfaVGLsdlpaaiaKNYGTLigWTRGQFWRWVLNSLIYSGVSALVGTL 129
Cdd:COG1175   28 LLLLLVFVLYPLLYTLYLSF-TDWNLLGPPPEF--VGL--------DNYARL--FTDPRFWNALGNTLLFTVVSVPLQLV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 130 VAVMAGYATAKfNFKGKNLAIGVIMGCMLMPAALLTI-------PQY----SIFHAMHLTNT---------MLSIIIPCC 189
Cdd:COG1175   95 LGLLLALLLNR-KLRGRGFFRTLFFLPWVISPVVVALiwkwlfnPDYgllnALLGALGLEPInwlgdpslaLPAVIIVTV 173

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 291516422 190 VSPFGF----FLGrvyAQTSVPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVATWNNFLLPLMM 258
Cdd:COG1175  174 WKGTGFnmliFLA---GLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVL 243
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 114-298 6.58e-14

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 68.84  E-value: 6.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 114 LNSLIYSGVSALVGTLVAVMAGYATAKFNFKGKNLAIGVIMGCMLMPAALLTIPQYSIFHAMHLTNTMLSIIIPCCVSPF 193
Cdd:cd06261    2 LNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALILAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 194 GFFLG-----RVYAQTSVPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVATWNNFLLPLMMVSSDTLKPvT 268
Cdd:cd06261   82 LLIAPfarliRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGP-G 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 291516422 269 LGLYGMVSLATFTDRGALMMGALLGVLPVI 298
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
104-319 5.63e-11

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 63.26  E-value: 5.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 104 WTRGQFWRWVLNSLIYSGVSALVGTLVAVMAGYATAKFNFKGKNLAIGVIMGCMLMPAALLTIPQYSIFHAMHLTNTMLS 183
Cdd:COG1178   47 LSDPYLWRALGNTLLLALLVTLLSLLLGVPLAWLLARTDFPGRRLLRWLLLLPLALPPYVVALAWIALFGPNGLLNTLLR 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 184 IIIPCCVSPFGFFLGRVYAQT----------------SVPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVA 247
Cdd:COG1178  127 ALFGLEPPDIYGLGGIILVLVlfnypyvylllraalrSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLL 206

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291516422 248 TWNNFLLPLMM-VSSDTLkpvTLGLYgmvslATFTDRGALMMGALLGV--LPVIVLFLGLQRYWQAGLAAGAVKG 319
Cdd:COG1178  207 CLADFGTPLVLgGGYTTL---TTAIY-----QAWLGDFDLGAAAALALvlLLLVLLLLLLERRLRRRRRYATVGG 273
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 127-307 1.09e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 56.92  E-value: 1.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422  127 GTLVAVMAGYataKFNFKGKNLAIGVIMGCMLMPAALLTIPQYSIFHAMHLTNTMLSIIIPCCVSPFGFFLG-RVYAQTS 205
Cdd:pfam00528   1 GIPLGIIAAL---RRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLiRRAALRS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422  206 VPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVATWNNFLLPLMMVSSDTL-KPVTLGLYGMVslatFTDRG 284
Cdd:pfam00528  78 LPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLgLLLIEAILGYD----YPEIQ 153

                         170       180
                  ....*....|....*....|...
gi 291516422  285 ALMMGALLGVLPVIVLFLGLQRY 307
Cdd:pfam00528 154 GPVLAAALILLLLNLLVDILQRL 176
malG PRK10998
maltose ABC transporter permease MalG;
111-319 2.76e-09

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 57.03  E-value: 2.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 111 RWVLNSLIYSGVSALVGTLVAVMAGYATAKFNFKGKNLAIGVIMGCMLMPAALLTIPQYSIFHAMHL------TNTMLSI 184
Cdd:PRK10998  83 LWLWNSVKVAGITAIGIVALSTTCAYAFARMRFKGKATLLKGMLIFQMFPAVLSLVALYALFDRLGQyipfigLNTHGGV 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 185 IIPccvspfgfFLGRV---------YAQTsVPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVATWNNF--- 252
Cdd:PRK10998 163 IFA--------YLGGIalhvwtikgYFET-IDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVpva 233

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 291516422 253 LLPLMMVSSDTLKpVTLGLYGMVSLATFTDRGALmmgALLGVLPVIVLFLGLQRYWQAGLAAGAVKG 319
Cdd:PRK10998 234 SLLLRDVNSYTLA-VGMQQYLNPQNYLWGDFAAA---AVLSAIPITVVFLLAQRWLVGGLTAGGVKG 296
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 49-304 1.20e-07

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 52.07  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422  49 VLVFALIYFLFPIYWAIIASTKTPSQMTG-SNGLWFAvglsdlpaaiakNYGTLigWTRGQFWRWVLNSLIYSGVSALVG 127
Cdd:COG1176   18 ALLWLLLFFVLPLLLLLVYSFTTRDPYGGvVPGFTLE------------NYARL--FTDPLYLKVLLRTLWIALLTTLIC 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 128 TLVAVMAGYATAKFNFKGKNLAIGVIMGCMLMPA-----ALLTIPQY-----SIFHAMHLTNTMLSIIipccVSPFGFFL 197
Cdd:COG1176   84 LLLGYPIAYFLARAPPRWRNLLLLLVILPFWTSFlvrtyAWIVLLGRngllnSLLLALGLIDEPLRLL----YTEFAVVI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 198 GRVYAQT------------SVPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVATWNNFLLPLMMVSSDTLk 265
Cdd:COG1176  160 GLVYVYLpfmvlplyaaleKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPALLGGGKVL- 238

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 291516422 266 pvtlgLYGMVSLATFTDRGALMMGALLGVLPVIVLFLGL 304
Cdd:COG1176  239 -----MIGNLIYQQFLSALNWPLAAALAVVLLLIVLLVL 272
potC PRK09500
spermidine/putrescine ABC transporter membrane protein; Reviewed
 114-303 7.35e-07

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 236542 [Multi-domain]  Cd Length: 256  Bit Score: 49.60  E-value: 7.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 114 LNSLIYSGVSALVGTLVAVMAGYATAKFNFKGKNLAIGVIMGCMLMPAALLTIPQYSIFHAMHLTNTMLSIIIPCCVSPF 193
Cdd:PRK09500  60 QHSLTMAVFSATFATLIGSLTAVALYRYRFRGKKFVSGMLFVVMMSPDIVMAISLLVLFMLLGIQLGFWSLLFAHITFCL 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 194 GFFLGRVYAQTS-VPNELLEAARIDGASEARIFFTIVLRILAPAMVTIFLFLFVATWNNFLLPlMMVSSDTLKPVTLGLY 272
Cdd:PRK09500 140 PFVVVTVYSRLKgFDVRMLEAAKDLGASEFTILRKIILPLALPAVAAGWLLSFTLSLDDVVVS-SFVTGPSYEILPLKIY 218

                        170       180       190
                 ....*....|....*....|....*....|.
gi 291516422 273 GMVSLATFTDRGALmmGALLGVLPVIVLFLG 303
Cdd:PRK09500 219 SMVKVGVSPEVNAL--ATILLVLSLVLVILS 247
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 116-239 2.65e-03

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 38.96  E-value: 2.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291516422 116 SLIYSGVSALVGTLVAVMAGYATAKFNFKGKNLAIGVIMGCMLMPAALLTIPQYSIFHAMHLTNTMLSiiipccvsPFGF 195
Cdd:COG0555   59 SLGTALIAALINLVFGLPLAWVLVRYRFPGKRLVDALVDLPFALPTAVAGIALLLLFGPNGWLGQLLA--------PLGI 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291516422 196 -----FLGRVYAQT----------------SVPNELLEAARIDGASEARIFFTIVLRILAPAMVT 239
Cdd:COG0555  131 kvaftPLGIVLAQTfvslpfvvrtvqpvleELDPELEEAAATLGASRWQTFRRVILPLLLPALLT 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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