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Conserved domains on  [gi|313713688|emb|CBJ05246|]
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recombinase A, partial [Propionibacterium freudenreichii]

Protein Classification

recombinase RecA family protein( domain architecture ID 1000164)

recombinase RecA catalyzes an ATP-dependent DNA strand-exchange reaction, which is a critical step in the repair of DNA double-strand breaks by homologous recombination

CATH:  3.30.250.10|3.40.50.300
Gene Ontology:  GO:0005524|GO:0003697|GO:0006310|GO:0006281|GO:0140664|GO:0003684|GO:0016887
PubMed:  12045091|9187054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
recA super family cl35814
recombinase A; Provisional
 1-90 4.58e-45

recombinase A; Provisional


The actual alignment was detected with superfamily member PRK09354:

Pssm-ID: 236476 [Multi-domain]  Cd Length: 349  Bit Score: 148.40  E-value: 4.58e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313713688   1 APPFKQAEFDILYGKGISREGSLIDMGVDAGIVRKAGAWFTYGDDQLGQGKENARTFLITHPEVASDIEHKIRVKLGLDA 80
Cdd:PRK09354 253 APPFKQAEFDIMYGEGISREGELIDLGVELGIIEKSGAWYSYNGEKIGQGRENAKQYLKENPELADEIEKKIREKLGLSA 332

                         90
                 ....*....|
gi 313713688  81 SDEVPEGIDP 90
Cdd:PRK09354 333 AAAEEEEEED 342
 
Name Accession Description Interval E-value
recA PRK09354
recombinase A; Provisional
 1-90 4.58e-45

recombinase A; Provisional


Pssm-ID: 236476 [Multi-domain]  Cd Length: 349  Bit Score: 148.40  E-value: 4.58e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313713688   1 APPFKQAEFDILYGKGISREGSLIDMGVDAGIVRKAGAWFTYGDDQLGQGKENARTFLITHPEVASDIEHKIRVKLGLDA 80
Cdd:PRK09354 253 APPFKQAEFDIMYGEGISREGELIDLGVELGIIEKSGAWYSYNGEKIGQGRENAKQYLKENPELADEIEKKIREKLGLSA 332

                         90
                 ....*....|
gi 313713688  81 SDEVPEGIDP 90
Cdd:PRK09354 333 AAAEEEEEED 342
RecA COG0468
RecA/RadA recombinase [Replication, recombination and repair];
1-94 8.06e-44

RecA/RadA recombinase [Replication, recombination and repair];


Pssm-ID: 440236 [Multi-domain]  Cd Length: 351  Bit Score: 145.31  E-value: 8.06e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313713688   1 APPFKQAEFDILYGKGISREGSLIDMGVDAGIVRKAGAWFTYGDDQLGQGKENARTFLITHPEVASDIEHKIRVKLGLDA 80
Cdd:COG0468  256 APPFKEAEFDIMYGEGISKEGELLDLAVELGIIEKSGAWYSYGGERLGQGRENAKQFLKENPELAEEIEAKIREKLGLGA 335

                         90
                 ....*....|....
gi 313713688  81 SDEVPEGIDPRTGE 94
Cdd:COG0468  336 VSEAAAAEEEEDEE 349
tigrfam_recA TIGR02012
protein RecA; This model describes orthologs of the recA protein. RecA promotes hybridization ...
 1-73 5.90e-37

protein RecA; This model describes orthologs of the recA protein. RecA promotes hybridization of homolgous regions of DNA. A segment of ssDNA can be hybridized to another ssDNA region, or to a dsDNA region. ATP is hydrolyzed in the process. Part of the SOS respones, it is regulated by LexA via autocatalytic cleavage. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 162659 [Multi-domain]  Cd Length: 321  Bit Score: 126.72  E-value: 5.90e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 313713688    1 APPFKQAEFDILYGKGISREGSLIDMGVDAGIVRKAGAWFTYGDDQLGQGKENARTFLITHPEVASDIEHKIR 73
Cdd:TIGR02012 248 APPFREAEFDILYGEGISKLGEIIDLAVELDIIKKSGSWYSYGDEKLGQGRENAKAFLKENPELAQEIEKKVR 320
RecA cd00983
recombinase A; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ...
 1-19 2.66e-06

recombinase A; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange.


Pssm-ID: 410863 [Multi-domain]  Cd Length: 235  Bit Score: 43.70  E-value: 2.66e-06
                         10
                 ....*....|....*....
gi 313713688   1 APPFKQAEFDILYGKGISR 19
Cdd:cd00983  217 APPFKQAEFDILYGEGISR 235
RecA pfam00154
recA bacterial DNA recombination protein; RecA is a DNA-dependent ATPase and functions in DNA ...
 1-18 4.61e-06

recA bacterial DNA recombination protein; RecA is a DNA-dependent ATPase and functions in DNA repair systems. RecA protein catalyzes an ATP-dependent DNA strand-exchange reaction that is the central step in the repair of dsDNA breaks by homologous recombination.


Pssm-ID: 425488 [Multi-domain]  Cd Length: 262  Bit Score: 43.16  E-value: 4.61e-06
                          10
                  ....*....|....*...
gi 313713688    1 APPFKQAEFDILYGKGIS 18
Cdd:pfam00154 245 APPFKEAEFDIMYGEGIS 262
 
Name Accession Description Interval E-value
recA PRK09354
recombinase A; Provisional
 1-90 4.58e-45

recombinase A; Provisional


Pssm-ID: 236476 [Multi-domain]  Cd Length: 349  Bit Score: 148.40  E-value: 4.58e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313713688   1 APPFKQAEFDILYGKGISREGSLIDMGVDAGIVRKAGAWFTYGDDQLGQGKENARTFLITHPEVASDIEHKIRVKLGLDA 80
Cdd:PRK09354 253 APPFKQAEFDIMYGEGISREGELIDLGVELGIIEKSGAWYSYNGEKIGQGRENAKQYLKENPELADEIEKKIREKLGLSA 332

                         90
                 ....*....|
gi 313713688  81 SDEVPEGIDP 90
Cdd:PRK09354 333 AAAEEEEEED 342
RecA COG0468
RecA/RadA recombinase [Replication, recombination and repair];
1-94 8.06e-44

RecA/RadA recombinase [Replication, recombination and repair];


Pssm-ID: 440236 [Multi-domain]  Cd Length: 351  Bit Score: 145.31  E-value: 8.06e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313713688   1 APPFKQAEFDILYGKGISREGSLIDMGVDAGIVRKAGAWFTYGDDQLGQGKENARTFLITHPEVASDIEHKIRVKLGLDA 80
Cdd:COG0468  256 APPFKEAEFDIMYGEGISKEGELLDLAVELGIIEKSGAWYSYGGERLGQGRENAKQFLKENPELAEEIEAKIREKLGLGA 335

                         90
                 ....*....|....
gi 313713688  81 SDEVPEGIDPRTGE 94
Cdd:COG0468  336 VSEAAAAEEEEDEE 349
recA PRK09519
intein-containing recombinase RecA;
1-90 1.79e-37

intein-containing recombinase RecA;


Pssm-ID: 77219 [Multi-domain]  Cd Length: 790  Bit Score: 132.91  E-value: 1.79e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313713688   1 APPFKQAEFDILYGKGISREGSLIDMGVDAGIVRKAGAWFTYGDDQLGQGKENARTFLITHPEVASDIEHKIRVKLGLDA 80
Cdd:PRK09519 693 SPPFKQAEFDILYGKGISREGSLIDMGVDQGLIRKSGAWFTYEGEQLGQGKENARNFLVENADVADEIEKKIKEKLGIGA 772

                         90
                 ....*....|...
gi 313713688  81 ---SDEVPEGIDP 90
Cdd:PRK09519 773 vvtDDPSNDGVLP 785
tigrfam_recA TIGR02012
protein RecA; This model describes orthologs of the recA protein. RecA promotes hybridization ...
 1-73 5.90e-37

protein RecA; This model describes orthologs of the recA protein. RecA promotes hybridization of homolgous regions of DNA. A segment of ssDNA can be hybridized to another ssDNA region, or to a dsDNA region. ATP is hydrolyzed in the process. Part of the SOS respones, it is regulated by LexA via autocatalytic cleavage. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 162659 [Multi-domain]  Cd Length: 321  Bit Score: 126.72  E-value: 5.90e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 313713688    1 APPFKQAEFDILYGKGISREGSLIDMGVDAGIVRKAGAWFTYGDDQLGQGKENARTFLITHPEVASDIEHKIR 73
Cdd:TIGR02012 248 APPFREAEFDILYGEGISKLGEIIDLAVELDIIKKSGSWYSYGDEKLGQGRENAKAFLKENPELAQEIEKKVR 320
RecA cd00983
recombinase A; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ...
 1-19 2.66e-06

recombinase A; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange.


Pssm-ID: 410863 [Multi-domain]  Cd Length: 235  Bit Score: 43.70  E-value: 2.66e-06
                         10
                 ....*....|....*....
gi 313713688   1 APPFKQAEFDILYGKGISR 19
Cdd:cd00983  217 APPFKQAEFDILYGEGISR 235
RecA pfam00154
recA bacterial DNA recombination protein; RecA is a DNA-dependent ATPase and functions in DNA ...
 1-18 4.61e-06

recA bacterial DNA recombination protein; RecA is a DNA-dependent ATPase and functions in DNA repair systems. RecA protein catalyzes an ATP-dependent DNA strand-exchange reaction that is the central step in the repair of dsDNA breaks by homologous recombination.


Pssm-ID: 425488 [Multi-domain]  Cd Length: 262  Bit Score: 43.16  E-value: 4.61e-06
                          10
                  ....*....|....*...
gi 313713688    1 APPFKQAEFDILYGKGIS 18
Cdd:pfam00154 245 APPFKEAEFDIMYGEGIS 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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