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Conserved domains on  [gi|261246377|emb|CBG24186|]
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putative membrane transporter [Salmonella enterica subsp. enterica serovar Typhimurium str. D23580]

Protein Classification

MFS transporter( domain architecture ID 11485445)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
1-400 0e+00

multidrug efflux MFS transporter MdtH;


:

Pssm-ID: 183255  Cd Length: 400  Bit Score: 738.41  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377   1 MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIV 80
Cdd:PRK11646   1 MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  81 TGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ 160
Cdd:PRK11646  81 TGMLMRAAGFATMAIAHEPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 161 YDFRLVCATGAILFILCALFNAWLLPAWKLSTVRTPVREGMRRVMSDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDIAG 240
Cdd:PRK11646 161 YDFRLVCATGAVLFVLAAAFNAWLLPAYKLSTVRTPVREGMTRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 241 SPAAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARET 320
Cdd:PRK11646 241 SPSAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARET 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 321 LSASLADARARGSYMGFSRLGLAIGGAIGYIGGGWLFDMGKALAQPELPWMMLGIIGFITFLALGWQFSHKRTPRRMLEP 400
Cdd:PRK11646 321 LSASLADARARGSYMGFSRLGLALGGAIGYIGGGWLFDLGKALNQPELPWMMLGIIGLITLLALYWQFSQKRIARRMLER 400
 
Name Accession Description Interval E-value
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
1-400 0e+00

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 738.41  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377   1 MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIV 80
Cdd:PRK11646   1 MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  81 TGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ 160
Cdd:PRK11646  81 TGMLMRAAGFATMAIAHEPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 161 YDFRLVCATGAILFILCALFNAWLLPAWKLSTVRTPVREGMRRVMSDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDIAG 240
Cdd:PRK11646 161 YDFRLVCATGAVLFVLAAAFNAWLLPAYKLSTVRTPVREGMTRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 241 SPAAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARET 320
Cdd:PRK11646 241 SPSAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARET 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 321 LSASLADARARGSYMGFSRLGLAIGGAIGYIGGGWLFDMGKALAQPELPWMMLGIIGFITFLALGWQFSHKRTPRRMLEP 400
Cdd:PRK11646 321 LSASLADARARGSYMGFSRLGLALGGAIGYIGGGWLFDLGKALNQPELPWMMLGIIGLITLLALYWQFSQKRIARRMLER 400
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 13-388 2.89e-85

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 264.09  E-value: 2.89e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  13 YFLLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFAT 92
Cdd:cd17329    2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  93 MGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAI 172
Cdd:cd17329   82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 173 LFILCALFNAWLLPAWKLSTVR---TPVREGMRRVMSDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDIAG-SPAAVKWM 248
Cdd:cd17329  162 LFLLAALVLLFLLPETRPKRRAaekTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGlGESLLGLL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 249 YAIEACLSLTLLYPIARWSEkRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARETLSASLADA 328
Cdd:cd17329  242 LALNALLIVLLQFPVARLVE-RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPP 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 329 RARGSYMGFSRLGLAIGGAIGYIGGGWLFDMGkalaQPELPWMMLGIIGFITFLALGWQF 388
Cdd:cd17329  321 DKRGSYMGFYALAWGLGRAIGPLVGGLLLDLL----GPGLPWLILAALGLIAAALLLGLQ 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-337 3.88e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 118.92  E-value: 3.88e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377   1 MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIrFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIV 80
Cdd:COG2814    1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  81 TGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ 160
Cdd:COG2814   80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 161 Y-DFRLVCATGAILFILCALFNAWLLPAwKLSTVRTPVREGMRRVMSDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDIA 239
Cdd:COG2814  160 LfGWRWVFLVNAVLALLALLLLLRLLPE-SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 240 GSPAAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARE 319
Cdd:COG2814  239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQ 318

                        330
                 ....*....|....*...
gi 261246377 320 TLSASLADARARGSYMGF 337
Cdd:COG2814  319 ALVAELAPPEARGRASGL 336
MFS_1 pfam07690
Major Facilitator Superfamily;
15-337 3.75e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 90.56  E-value: 3.75e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377   15 LLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMG 94
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377   95 IAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLL-QYDFRLVCATGAIL 173
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  174 FILCALFNAWLLPAWKLSTVRT-----PVREGMRRVMSDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDIAGSPAAVKWM 248
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPaeearLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  249 YAIEACLSLTLLYPIARWSEK--RFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARETLSASLA 326
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRlgRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320

                         330
                  ....*....|.
gi 261246377  327 DARARGSYMGF 337
Cdd:pfam07690 321 PKEERGTASGL 331
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 63-186 8.40e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 50.82  E-value: 8.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377   63 GIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMM 142
Cdd:TIGR00895  69 ALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFC 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 261246377  143 QDSAGAVIGALLGSWLL-QYDFRLVCATGAILFILCALFNAWLLP 186
Cdd:TIGR00895 149 GYPIGAAVGGFLAGWLIpVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
 
Name Accession Description Interval E-value
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
1-400 0e+00

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 738.41  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377   1 MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIV 80
Cdd:PRK11646   1 MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  81 TGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ 160
Cdd:PRK11646  81 TGMLMRAAGFATMAIAHEPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 161 YDFRLVCATGAILFILCALFNAWLLPAWKLSTVRTPVREGMRRVMSDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDIAG 240
Cdd:PRK11646 161 YDFRLVCATGAVLFVLAAAFNAWLLPAYKLSTVRTPVREGMTRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 241 SPAAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARET 320
Cdd:PRK11646 241 SPSAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARET 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 321 LSASLADARARGSYMGFSRLGLAIGGAIGYIGGGWLFDMGKALAQPELPWMMLGIIGFITFLALGWQFSHKRTPRRMLEP 400
Cdd:PRK11646 321 LSASLADARARGSYMGFSRLGLALGGAIGYIGGGWLFDLGKALNQPELPWMMLGIIGLITLLALYWQFSQKRIARRMLER 400
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 13-388 2.89e-85

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 264.09  E-value: 2.89e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  13 YFLLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFAT 92
Cdd:cd17329    2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  93 MGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAI 172
Cdd:cd17329   82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 173 LFILCALFNAWLLPAWKLSTVR---TPVREGMRRVMSDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDIAG-SPAAVKWM 248
Cdd:cd17329  162 LFLLAALVLLFLLPETRPKRRAaekTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGlGESLLGLL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 249 YAIEACLSLTLLYPIARWSEkRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARETLSASLADA 328
Cdd:cd17329  242 LALNALLIVLLQFPVARLVE-RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPP 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 329 RARGSYMGFSRLGLAIGGAIGYIGGGWLFDMGkalaQPELPWMMLGIIGFITFLALGWQF 388
Cdd:cd17329  321 DKRGSYMGFYALAWGLGRAIGPLVGGLLLDLL----GPGLPWLILAALGLIAAALLLGLQ 376
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 15-382 2.49e-30

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 119.84  E-value: 2.49e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  15 LLIDNMLVVLGFFVVFPLISIrFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMG 94
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPA-LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  95 IAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQY---DFRLVCATGA 171
Cdd:cd06174   80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgfGWRAVFLIAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 172 ILFILCALFNAWLLPAWKLSTVR-------TPVREGMRRVMSDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDIAG-SPA 243
Cdd:cd06174  160 ALALLAAILLLLVVPDPPESARAkneeassKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlSVA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 244 AVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARETLSA 323
Cdd:cd06174  240 VAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 261246377 324 SLADARARGSYMGFSRLGLAIGGAIGYIGGGWLFDMGKALAQPELPWMMLGIIGFITFL 382
Cdd:cd06174  320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-337 3.88e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 118.92  E-value: 3.88e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377   1 MSRVSQARNLGKYFLLIDNMLVVLGFFVVFPLISIrFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIV 80
Cdd:COG2814    1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  81 TGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ 160
Cdd:COG2814   80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 161 Y-DFRLVCATGAILFILCALFNAWLLPAwKLSTVRTPVREGMRRVMSDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDIA 239
Cdd:COG2814  160 LfGWRWVFLVNAVLALLALLLLLRLLPE-SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 240 GSPAAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARE 319
Cdd:COG2814  239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQ 318

                        330
                 ....*....|....*...
gi 261246377 320 TLSASLADARARGSYMGF 337
Cdd:COG2814  319 ALVAELAPPEARGRASGL 336
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 15-339 3.03e-28

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 114.21  E-value: 3.03e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  15 LLIDNMLVVLGFFVVFPLISIrFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMG 94
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPL-YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  95 IAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ-YDFRLVCATGAIL 173
Cdd:cd17325   80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 174 FILCALFNAWLLP-----AWKLSTVRTPVREGMRRVMSDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDIAG-SPAAVKW 247
Cdd:cd17325  160 ALLALVLALLLLPeprppPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 248 MYAIEACLSLTLLYPIARWSEKRFRLeHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARETLSASLAD 327
Cdd:cd17325  240 LFGAQGLASALSQPPAGKLSDRIGRK-PLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318

                        330
                 ....*....|..
gi 261246377 328 ARARGSYMGFSR 339
Cdd:cd17325  319 PEGRGTAMGLFN 330
MFS_1 pfam07690
Major Facilitator Superfamily;
15-337 3.75e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 90.56  E-value: 3.75e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377   15 LLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMG 94
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377   95 IAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLL-QYDFRLVCATGAIL 173
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  174 FILCALFNAWLLPAWKLSTVRT-----PVREGMRRVMSDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDIAGSPAAVKWM 248
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPaeearLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  249 YAIEACLSLTLLYPIARWSEK--RFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARETLSASLA 326
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRlgRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320

                         330
                  ....*....|.
gi 261246377  327 DARARGSYMGF 337
Cdd:pfam07690 321 PKEERGTASGL 331
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 20-180 3.78e-18

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 85.32  E-value: 3.78e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  20 MLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEP 99
Cdd:cd17325  209 FVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 100 WLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ-YDFRLVCATGAILFILCA 178
Cdd:cd17325  289 WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDaFGFATPFLAAAALLLLAA 368


                 ..
gi 261246377 179 LF 180
Cdd:cd17325  369 VL 370
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 62-336 1.03e-17

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 83.77  E-value: 1.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  62 LGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLM 141
Cdd:cd17474   50 LMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYE 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 142 MQDSAGAVIGALLGSWLLQYDFRLVCATGAILFILCALFNAWLLPAWKLSTVRTPV--REGMRRVMSDKRFVTYVLTLAG 219
Cdd:cd17474  130 AALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSAtkLRDLKKALRGRGLLTFLVSAFL 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 220 YYMLAVQVMLMLPIMVNDIAGSPAAVK-WMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQ 298
Cdd:cd17474  210 YFFLYFAFLTYLPFLLELLYGISPIIIgLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLA 289

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 261246377 299 QLFTLICAFYIGSVIAEPARETLSASLADARARGSYMG 336
Cdd:cd17474  290 LLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASS 327
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
20-337 6.93e-17

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 81.45  E-value: 6.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  20 MLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEP 99
Cdd:COG2271   19 YFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSF 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 100 WLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLL-QYDFRLVCATGAILFILCA 178
Cdd:COG2271   99 WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLaAFGWRAAFLILGLPGLLLA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 179 LFNAWLLpawklstvrtpvregmrrvmsdkrFVTYVLTLAGYYMLAVQvmlMLPIMVNDIAGSPAAVKWMYAIEACLSLT 258
Cdd:COG2271  179 LLRFWLL------------------------ALAYFLVYFALYGFLTW---LPTYLVEVRGLSLAQAGLLLSLPFLAGIV 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 259 LLYPIARWSEKRFRLEHRLMA-GLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARETLSASLADARARGSYMGF 337
Cdd:COG2271  232 GSLLGGWLSDRLGRRRKLVLAiGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL 311
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 37-340 7.08e-17

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 81.51  E-value: 7.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  37 FVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAH-----EPWLLWFSCFLSGL 111
Cdd:cd06173   25 LVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGI 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 112 GGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ-YDFRLVCATGAILFILCALFNAWLLPAWKL 190
Cdd:cd06173  105 ASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVAlLGPGGAFAINALSFLLSALLLLFIRRPPPA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 191 STVRTP------VREGMRRVMSDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDIAG-SPAAVKWMYAIEACLSLTLLYPI 263
Cdd:cd06173  185 APGESSslllrdLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGgGAAGYGLLLAAFGVGALLGALLL 264

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 261246377 264 ARWSeKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARETLSASLADARARGSYMGFSRL 340
Cdd:cd06173  265 GRLS-KRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNA 340
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 24-336 2.12e-16

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 79.95  E-value: 2.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  24 LGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLW 103
Cdd:cd17472   10 LGMFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLI 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 104 FSCFLSGLGGtlFDPPRSALVVKLIRPEQRGRFFSLLmmqdsaGAVIG-----ALLGSWLLQ--YDFRLVCATGAILFIL 176
Cdd:cd17472   90 LGRALQGSGA--ISSVVMALLADLTREENRTKAMALI------GASIGiafaiSMVLGPLLAahLGVSGLFLITAILSLV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 177 CALFNAWLLPAWKLS-TVRTPVREGMRRVMSDKRFVtyVLTLAGYYMLAVQVM--LMLPIMVNDIAGSPAAVKWMYAIEA 253
Cdd:cd17472  162 SLLILLFFVPDPPKIvQISEKEKKKLKKLLKNKRLL--RLDFSIFILHFVLMAffYILPLLLTQLGGGKGQLWKVYLPAI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 254 CLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPIGM-VGNLQQLFTLICAFYIGSVIAEPARETLSASLADARARG 332
Cdd:cd17472  240 LIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFaATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRG 319


                 ....
gi 261246377 333 SYMG 336
Cdd:cd17472  320 TAMG 323
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 25-337 3.85e-16

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 79.12  E-value: 3.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  25 GFFVVFPLisirFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGA-KPMIVTGMLMRAAGFATMGIAHEPWLLW 103
Cdd:cd17370   17 MARSILPL----FLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKrKPLVILGYGLSALAKPLLALAGSWQLVL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 104 FSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQY---DFRLVCATGAI--LFILCA 178
Cdd:cd17370   93 LLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLlggNYRTIFLLAAIpaLLALLI 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 179 LFNAWLLPAWKLSTVRTPVREGMRRVmsDKRFVTYVLTLAGYYMLAVQVMLMLpIMVNDIAGSPAAVKWMYAIEACLSLT 258
Cdd:cd17370  173 LLFVVKEYPRPPKLRKKSKKTSLKKL--PKAFWLYLLAVALFALGNFSFAFLI-LRAQELGLSAALIPLLYALFNLVYAL 249

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 261246377 259 LLYPIARWSEkRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARETLSASLADARARGSYMGF 337
Cdd:cd17370  250 AAYPAGRLSD-RIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGL 327
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
20-337 3.60e-14

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 73.38  E-value: 3.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  20 MLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEP 99
Cdd:COG2223   14 FFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSY 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 100 WLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ-YDFRLVCATGAILFILCA 178
Cdd:COG2223   94 WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLILGILLLVVA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 179 LFNAWLL---PAWKLSTVRTPVREgMRRVMSDKRF----VTYVLTLAGYYMLAVQvmlmLPIMVNDIAGSPAAVKWMYAI 251
Cdd:COG2223  174 VLAWLFLrdpPAGAAAAAKASLRD-QLEALRDPRFwllsLLYFGTFGSFIGFSSW----LPPYLVDQFGLSAATAGLLAA 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 252 EACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPIGMV-GNLQQLFTLICAFYIGSVIAEPARETLSASLADARA 330
Cdd:COG2223  249 LFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAlGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKN 328


                 ....*..
gi 261246377 331 RGSYMGF 337
Cdd:COG2223  329 AGAVYGL 335
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 15-336 7.18e-13

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 69.16  E-value: 7.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  15 LLIDNMLVVLGFFVVFPLISIrFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMG 94
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPL-YAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  95 IAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ-YDFRLVcATGAIL 173
Cdd:cd17489   80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQhLGFAVL-FIVAAV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 174 FILCALFNAWLLPAwklsTVRTPVREGMRRVMSDKRFVTYVLTLAGYYMLAVQ-----VMLMLPIMVNDIagsPAAVKWM 248
Cdd:cd17489  159 LALLALLLVFLVKD----PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASiaygaISTFLPLYAAER---GISNAGL 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 249 YAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARETLSASLADA 328
Cdd:cd17489  232 FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPP 311


                 ....*...
gi 261246377 329 RARGSYMG 336
Cdd:cd17489  312 HRRGAANG 319
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 15-310 1.04e-12

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 68.73  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  15 LLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADR-FGAKPMIVTGMLMRAAGFATM 93
Cdd:cd17471    1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  94 GIAHEPW-LLWFSCFLSGLGGTLFdPPRSAL---VVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLL-QYDFRLVCA 168
Cdd:cd17471   81 AFLRNYWvLLLVGVVLLSLGAAAF-PQLFALareYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLdVLGFTGLFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 169 TGAILFILCALFNAWLLPAWKLSTVRTPVREGMRRVMSDKRFVTYVLTLAGYYMLAVQVMLMLPI-MVNDIAGSPAAVKW 247
Cdd:cd17471  160 LAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLyVTNELGGSESWVGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 261246377 248 MYAIEACLSLTLLYPIARWSeKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTL--ICAFYIG 310
Cdd:cd17471  240 LFGLAAALEIPIMLLAGLLA-KRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALqlLNAIFIG 303
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
63-245 5.07e-11

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 63.72  E-value: 5.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  63 GIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVkLIRPEQRGRFFSLLMM 142
Cdd:COG0738   60 SLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVA-ALGPETAASRLNLLHA 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 143 QDSAGAVIGALLGSWLLQYDF-----RLVCATGAILFILCALFNAWLLPAWKL-STVRTPVREGMRRVMSDKRFVTYVLT 216
Cdd:COG0738  139 FFSLGALLGPLLGGLLILLGLslswhLPYLILAVLLLLLALLFLRSKLPEIEEeEEEAAGSAASLKSLLKNPRLLLGGLA 218

                        170       180
                 ....*....|....*....|....*....
gi 261246377 217 LAGYYMLAVQVMLMLPIMVNDIAGSPAAV 245
Cdd:COG0738  219 IFLYVGAEGAIGDWLPLYLKDVLGLSEAT 247
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 24-338 6.98e-11

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 62.98  E-value: 6.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  24 LGFFVVFPLIS--IRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWL 101
Cdd:cd17330   10 LGFGIVFPVLPfyVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 102 LWFSCFLSGLGGTLFdPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ-YDFRLVCATGAILFILCALF 180
Cdd:cd17330   90 LFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTpYGYALPFLVAAALALLNLVL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 181 NAWLLPAwklstvrtpvregMRRVmsdkrFVTYVLTLAGYYMLAVQVMLMLPIMVNDiagSPAAVKWMYAIEACLSLTLL 260
Cdd:cd17330  169 VLFFLPP-------------LRRL-----LLVYFLIALAFAGLESVFSLFLKDRFGF---SPSQIGLLLALVGIAGILAQ 227

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 261246377 261 YPIARWSEKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARETLSASLADARARGSYMGFS 338
Cdd:cd17330  228 LLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGII 305
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
24-399 2.14e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 61.84  E-value: 2.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  24 LGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAK-----PMIVTGMLMRAAGFATMGIA-- 96
Cdd:COG2211   24 LAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrPWILIGAIPLALSFVLLFTApd 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  97 -HEPWLLWFSC---FLSGLGGTLFDPPRSALVVKLIR-PEQRGRFFSLLMMQDSAGAVIGALLGSWLLQY-------DFR 164
Cdd:COG2211  104 lSPTGKLIYALvtyLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaalGYR 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 165 LVCATGAILFILCALFNAWLLP-AWKLSTVRTPVREGMRRVMSDKRFVTYVL-TLAGYYMLAVQVMLMLPIMVNDIAGSP 242
Cdd:COG2211  184 LTALIFAVLGLLAFLLTFFGTKeRPVPEEEKVSLKESLKALLKNRPFLLLLLaYLLFFLALALVAALLLYYFKYVLGLSA 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 243 AAVKWMYAIEACLSLTLLYPIARWSeKRFRLEHRLMAGLLVMSLSMLPIGMVG--NLQQLFTLICAFYIGSVIAEPARET 320
Cdd:COG2211  264 ALVGLLLALYFLAALLGAPLWPRLA-KRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWA 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 321 LSASLADA-------RARGSYMGFSRLGLAIGGAIGYIGGGWLFDMG---KALAQPE-----LPWMMLGIIGFITFLALG 385
Cdd:COG2211  343 MLADVVDYdewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLALFgyvAGAAQSPsaltgIRLLFFLLPAVLLLLAAL 422

                        410
                 ....*....|....
gi 261246377 386 WQFSHKRTPRRMLE 399
Cdd:COG2211  423 LLLFYPLTRERHAE 436
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
39-295 5.34e-10

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 60.66  E-value: 5.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  39 DQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDP 118
Cdd:COG2807   46 ADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNV 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 119 PRSALvVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ-YDFRLVCATGAILFILCALFNAWLLPAWKLSTVRTPV 197
Cdd:COG2807  126 LLPGL-IKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAaLGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPA 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 198 REGMRRVMSDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDIAGSPAAVKWMYAIEACLSLTLLYPIARWSEkRFRLEHRL 277
Cdd:COG2807  205 AASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD-RLGDRRPL 283

                        250
                 ....*....|....*...
gi 261246377 278 MAGLLVMSLsmlpIGMVG 295
Cdd:COG2807  284 LLLLGLLGL----AGLLG 297
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 15-337 1.60e-09

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 59.21  E-value: 1.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  15 LLIDNMLVVLGFFVVFPLISIRFvdqmGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMG 94
Cdd:cd17355   11 ILILSWGIRYYFGVFIIPIIAEF----GWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  95 IAHEPWLLWFSCFLSGLGGTL-FDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLL-QYDFRLVCATGAI 172
Cdd:cd17355   87 LATSLWQLYLLWGLLGGGGAGtLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIeAFGWRTALLVLAL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 173 LFILCALFNAWLLPAWKLSTVRTPV--------REGMRRVMSDKRFVTYVLT--LAGYYMLAVQVmlMLPIMVNDIAGSP 242
Cdd:cd17355  167 LALLVLVPVLLLLRRRPADLALRAYddaspaspGSTLKEALRSASFWLLALAffLCGFAVVGLIV--HLVPYLADRGISP 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 243 AAVKWMYAIEAcLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAE-PARETL 321
Cdd:cd17355  245 AAAAVALALIG-LFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATvPLTAAL 323

                        330
                 ....*....|....*.
gi 261246377 322 SASLADARARGSYMGF 337
Cdd:cd17355  324 AARYFGARSYGTLFGL 339
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 61-292 3.68e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 57.51  E-value: 3.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  61 GLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLL 140
Cdd:COG0477   64 IGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLW 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 141 MMQDSAGAVIGALLGSWLLQY-DFRLVCATGAILFILcALFNAWLLPAWKLSTVRTPVREGMRRVMSDKRFVTYVLTLAG 219
Cdd:COG0477  144 GAAIGLGLALGPLLGGLLVAAlGWRWIFLINAPLGLL-ALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLL 222

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 261246377 220 YYMLAVQVMLMLPIMVNDIAGSPAAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPIG 292
Cdd:COG0477  223 LLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 64-185 4.19e-09

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 57.57  E-value: 4.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  64 IFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQ 143
Cdd:cd17321   49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAV 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 261246377 144 DSAGAVIGALLGSWLLQYD-----FRLVCATGAILFILCALFNAWLL 185
Cdd:cd17321  129 VGIGAALGPLLGGLLLELFgwrwiFLINVPIGLVALLLARTFSGAVL 175
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 19-180 1.31e-08

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 56.08  E-value: 1.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  19 NMLVVLGFFVVFPLISirfVDQMGWAAVMVGIALGLrqfiqQGLGIFGGAI-----ADRFGAKPMIVTGMLMRAAGFATM 93
Cdd:cd06173  220 FALLGGALTVLLPLLA---KEVLGGGAAGYGLLLAA-----FGVGALLGALllgrlSKRRRRGRLLLIGALLLGLALLVL 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  94 GIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ-YDFRLVCATGAI 172
Cdd:cd06173  292 GLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADaLGLSAVFLLAGA 371


                 ....*...
gi 261246377 173 LFILCALF 180
Cdd:cd06173  372 LLLLAALL 379
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 67-333 2.76e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 55.25  E-value: 2.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  67 GAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSA 146
Cdd:cd17324   55 GPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 147 GAVIGALLGSWLLQY-DFRLVCATGAILFILCALFNAWLLPAWKLST-VRTPVREGMRRVMSDKR-FVTYVLTLAGYYML 223
Cdd:cd17324  135 GLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWRLLPSLPPKKpGSLGLLSSLLLLLRNPRlRLAYLITFLLFGGF 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 224 AVQVMLMLPIMVNDIAGSPAAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHrLMAGLLVMSLSMLPIGMVGNLQQLFTL 303
Cdd:cd17324  215 FALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRAL-LIALLLLAAALLLLTLLGPSPLLLLVG 293

                        250       260       270
                 ....*....|....*....|....*....|.
gi 261246377 304 ICAFYIGSVIAEPARETLSASLA-DARARGS 333
Cdd:cd17324  294 LVLWGLGFFAAHSALQTRVLRLApEARGLAS 324
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 39-337 8.43e-08

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 53.73  E-value: 8.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  39 DQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDP 118
Cdd:cd17319   31 KDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFP 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 119 PRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQY-DFRLVcatgailFILCALFNAWLLPAWKLSTvrtpv 197
Cdd:cd17319  111 GAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLfGWRWA-------FIIEGLLGLLLAVLWWFYL----- 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 198 regmrrvmsdKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDIAG-SPAAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHR 276
Cdd:cd17319  179 ----------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGfSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARR 248

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 261246377 277 L--MAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARETLSASLADARARGSYMGF 337
Cdd:cd17319  249 LviIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGL 311
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 40-342 1.24e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 53.35  E-value: 1.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  40 QMGWAAVMVGIALGLrqfiqqglgIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPP 119
Cdd:cd17320   37 QLTLSAYLLGFALGQ---------LLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVV 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 120 RSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLL-----QYDFRLVCATGAILFILCALFNAWLLPAWKLSTVR 194
Cdd:cd17320  108 ARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLlffgwRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 195 TPVREGMRRVMSDKRFVTYVLTLAGYY-MLAVQVMLMLPIMVNDIAGSPAAVKWMYAIEAcLSLTLLYPIARWSEKRFRL 273
Cdd:cd17320  188 SSLLRAYKRVLKNRRFLGYALALGLSFaGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNA-IALILGSLLNGRLVRRFGP 266

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 261246377 274 EHRLM-------AGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARETLSASLADARARGSYMGFSRLGL 342
Cdd:cd17320  267 RRLLRlglllllAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLI 342
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 8-158 1.81e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 52.55  E-value: 1.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377   8 RNLGKYFLLIdnmLVVLGFFVV----FPLISIRFVdQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGM 83
Cdd:cd17370  196 KKLPKAFWLY---LLAVALFALgnfsFAFLILRAQ-ELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGY 271

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 261246377  84 LMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLmmqdSAGAVIGALLGSWL 158
Cdd:cd17370  272 LSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLF----NTVVGIGWLLASLI 342
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 37-217 6.13e-07

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 51.02  E-value: 6.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  37 FVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLF 116
Cdd:cd17478   22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 117 DPPrSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLV-CATGAILFILCALFNAWLLPAWKLSTVRT 195
Cdd:cd17478  102 HPE-GARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGlLILLIIPGLAVALLLLRLRPLKKPEAKKA 180

                        170       180
                 ....*....|....*....|..
gi 261246377 196 PVREGMRRVMSDKRFVTYVLTL 217
Cdd:cd17478  181 AAKSSARSTLKGVWRALLLLLI 202
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 15-313 7.15e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 50.63  E-value: 7.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  15 LLIDNMLVVLGFFVVFPLISIRFvDQMGWAAVMVGIALGLrqfiqQGLGI-----FGGAIADRFGAKPMIVTGMLMRAAG 89
Cdd:cd17477    1 LLLSVALLGLGSGLLLPLLSLRL-EREGVSTALIGLVASA-----YYLGIllgspLVPRLIRRVGHIRAFAAGAAITAVS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  90 FATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVcAT 169
Cdd:cd17477   75 VLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPF-LI 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 170 GAILFILCALfnaWLLPAWKLSTVRTPVREGMRRVMSDKRFVTYVLTLAGYYMLAVQVMLMlPIMVNDIAGSPAAVKWMY 249
Cdd:cd17477  154 AAVLLLLALV---PLLLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLL-PLYGLRLGLSVAQAALLL 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 261246377 250 AIEACLSLTLLYPIARWSEKRFRLehRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVI 313
Cdd:cd17477  230 AAFVLGGLLLQWPLGWLADRFDRR--RVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAA 291
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 63-186 8.40e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 50.82  E-value: 8.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377   63 GIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMM 142
Cdd:TIGR00895  69 ALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFC 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 261246377  143 QDSAGAVIGALLGSWLL-QYDFRLVCATGAILFILCALFNAWLLP 186
Cdd:TIGR00895 149 GYPIGAAVGGFLAGWLIpVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 20-180 8.83e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 50.63  E-value: 8.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  20 MLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEP 99
Cdd:cd17324  208 FLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSP 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 100 WLLWFSCFLSGLGGTLFDPPRSALVVKLiRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ-YDFRLVCATGAILFILCA 178
Cdd:cd17324  288 LLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGLVLDhGGWAGVGWVGAALLLLAL 366


                 ..
gi 261246377 179 LF 180
Cdd:cd17324  367 LL 368
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 15-184 9.92e-07

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 50.27  E-value: 9.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  15 LLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIAL---GLRQFIQQGLgiFGGAIADRFGAKPMIVTGMLMRAAGFA 91
Cdd:cd17330  179 LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLalvGIAGILAQLL--LIPRLAKRLGERKLLRLGLLLAIIGLL 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  92 TMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGA 171
Cdd:cd17330  257 LLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLA 336

                        170
                 ....*....|...
gi 261246377 172 ILFILCALFNAWL 184
Cdd:cd17330  337 AGLLLIALFLLSL 349
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 13-180 1.18e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 50.26  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  13 YFLLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFAT 92
Cdd:cd17473  200 LPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLL 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  93 MGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQYD------FRLV 166
Cdd:cd17473  280 LALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTgglsgaFLIL 359

                        170
                 ....*....|....
gi 261246377 167 CATGAILFILCALF 180
Cdd:cd17473  360 GVLALVLAIVLLLL 373
MFS_1 pfam07690
Major Facilitator Superfamily;
12-152 1.24e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 50.11  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377   12 KYFLLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRA---A 88
Cdd:pfam07690 201 PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIlaaL 280

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 261246377   89 GFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGA 152
Cdd:pfam07690 281 GLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 65-337 2.69e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 49.11  E-value: 2.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  65 FGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQD 144
Cdd:cd17473   54 LAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAM 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 145 SAGAVIGALLGSWLLQYDFRLVCATGAILFILcALFNAWLLPAWKLSTVRTPVREGMRRVMSDKRFVTYVLTLAGYYMLA 224
Cdd:cd17473  134 SLGGVVFLLLGGALAEIGWRAPFLVYLLALPV-LILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLL 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 225 V-QVMLMLPIMVNDIA-GSPAAVKWMYAIeACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFT 302
Cdd:cd17473  213 FyVIPIQLPFLLQERGgGSAALIGLALAI-ASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLL 291

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 261246377 303 LICAFYIGSVIAEPARETLSASLADARARGSYMGF 337
Cdd:cd17473  292 GAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGI 326
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
62-176 3.39e-06

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 49.04  E-value: 3.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  62 LGIFGGAIADRF-GAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGR--FFS 138
Cdd:COG3104   71 TPLLGGWLADRLlGQRRAILLGGILMALGHFLLALPGGVTLFYLGLALIAVGNGLFKPNISSLVGQLYDPGDPRRdaGFT 150

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 261246377 139 LLMMQDSAGAVIGALLGSWLLQ-YDFRLVCATGAILFIL 176
Cdd:COG3104  151 IFYMGINIGAFLAPLLCGYLGEkYGWHYGFGAAAIGMLI 189
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 40-180 4.55e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 48.35  E-value: 4.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  40 QMGWA--AVMVGIALGlrqfiqqglGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFD 117
Cdd:cd17365   35 QLGPVgsAALFGMAIG---------ALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAM 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 261246377 118 PPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ-YDFRLVCATGAILFILCALF 180
Cdd:cd17365  106 PNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPaFGWRSVFLLGGVPPLILLPL 169
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 26-185 5.64e-06

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 48.04  E-value: 5.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  26 FFVVFPLISIRFV---DQMGWAAVMVGIALGLRQFIQqglgifgGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLL 102
Cdd:cd17312   22 FSVAKPPIVEEIGlskDDLGIIGSAFLIAYAVGKFIS-------GFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFF 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 103 WFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALL-GSWLLQYDFRLVCATGAILFILCALFN 181
Cdd:cd17312   95 AVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILaASLASYYGWRAAFLVPGIVGLVVAIIL 174


                 ....
gi 261246377 182 AWLL 185
Cdd:cd17312  175 FFFL 178
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 15-337 6.50e-06

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 47.99  E-value: 6.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  15 LLIDNMLVVLGFFVVFPLISIrFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGA-KPMIVTGMLMRAAGFATM 93
Cdd:cd17490    1 FLIIVFLFWFSQYVYVPFLSP-YAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKrKLFIIIGLLFTVLASLIM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  94 GIAHEPWLLWFSCFLSGLGGTLFdPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGS-----WLLQYDFRLVCA 168
Cdd:cd17490   80 ILFPSPWGLLIARFLSGIAAATW-VSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGliaehFGMRAPFLLAAL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 169 TGAILFILCALFNAWLLPAWKlstvRTPVREGMRRVMSDKRFVTY-VLTLAGYYMLAVQVMLMLPIMVNDIAGSPAAVKW 247
Cdd:cd17490  159 AGVLGFILSLFIKEERREKKP----VLTELKELLSVLKDKKLLFFsLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 248 M-------YAIEACLSLTLLYpiarwseKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSVIAEPARET 320
Cdd:cd17490  235 LsiiyllpNALASLLSGTLFY-------KKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMS 307

                        330
                 ....*....|....*..
gi 261246377 321 LSASLADARARGSYMGF 337
Cdd:cd17490  308 LSIEGVPAEQRSTAMGF 324
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 64-338 6.76e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 47.62  E-value: 6.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  64 IFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQ 143
Cdd:cd17475   49 LPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTG 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 144 DSAGAVIGALLGSWL-LQYDFRLVCATGAILFILCALFnAWLL----PAWKLSTVRT-PVREGMRRVMSDKRFvtYVLTL 217
Cdd:cd17475  129 VPLGGALAAALLPPLaLHYGWRAAFVVAGLVSILAAVL-FWLFyrepPAASAATESAsTLLRSLKEVLRNRDV--WLIAI 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 218 AGYYMLAVQVMLM--LPIMVNDIAG-SPAAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHR----LMAGLLVMSLSMLP 290
Cdd:cd17475  206 AGALLVAPQFALLtfLLLFLHDHLGlSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRpvlvITAAIAAAALLVLS 285

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 261246377 291 IGMVGNLQQLFTLICAFYIGSVIA-EPARETLSASLADARARGSYMGFS 338
Cdd:cd17475  286 LLSPGTPLWLLVLLLILLGLFAIGwNGLYLTLVAESAGPEQAGTALGLA 334
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 20-173 8.11e-06

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 47.57  E-value: 8.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  20 MLVVLGFFVVFPLISIRFVDQmgwAAVMVGIALGLrqfiQQGLGIFGGAIADRF-GAKPMIVTGMLMRAAGFATMGIA-H 97
Cdd:cd17346   21 MRAILILYLTAQLGDGFSEAD---AASIYGAYTAL----VYLTPIIGGWLADKVlGARRTVFIGGILMALGYLLLALSpF 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  98 EPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQ--RGRFFSLLMMQDSAGAVIGALLGSWL-LQYDFR---LVCATGA 171
Cdd:cd17346   94 SVSMLYLGLALIIVGNGLFKPNISSLVGKLYDENDprRDSGFSIFYMGINLGAFLAPLLCGTLgDNYGYHygfGLAAVGM 173


                 ..
gi 261246377 172 IL 173
Cdd:cd17346  174 LL 175
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 24-194 9.74e-06

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 47.22  E-value: 9.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  24 LGFFVVFPLISIRfVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLW 103
Cdd:cd17390   10 FGVSMILPLLSTH-IRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 104 FSCFLSGL-GGTLfdPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQYD--FRLVCATGAILFILCALF 180
Cdd:cd17390   89 LSRIPLGIfKHTQ--SLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDggFYYVALLCSAIFILNAGL 166

                        170
                 ....*....|....*.
gi 261246377 181 nAWLLPA--WKLSTVR 194
Cdd:cd17390  167 -VWFLLSklWDLLLVR 181
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 67-306 1.01e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 47.19  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  67 GAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSA 146
Cdd:cd17503   52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILL 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 147 GAVIGALLGSWLLQY-----DFRLVCATGAILFILCALFNAWLLpawklstvrtpvregmrrvmSDKRFVTYVLTLAGYY 221
Cdd:cd17503  132 APAIGPTLGGWLTDNlswrwIFYINLPIGILALLLAPLLDLRLF--------------------KDRNFTLGLLLSFLLG 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 222 MLAVQVMLMLPIMVNDIAGSPAAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLF 301
Cdd:cd17503  192 LGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLW 271


                 ....*
gi 261246377 302 TLICA 306
Cdd:cd17503  272 LIILP 276
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 10-176 1.48e-05

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 46.68  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  10 LGKYFLLIDNMLVVLGFFVVFplisirFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAG 89
Cdd:COG2270  244 LLAYFFYRDGVQTVIAFAGIY------AAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVV 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  90 FATMGIAHEPWLLWFSCFLSGLG-GTLFDPPRSaLVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQY--DFRLV 166
Cdd:COG2270  318 CLAAYFLTTALAFWILGLLIGLVmGGIQALSRS-LLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLtgSQRLG 396

                        170
                 ....*....|
gi 261246377 167 CATGAILFIL 176
Cdd:COG2270  397 ILSLIVFFVI 406
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 63-189 1.90e-05

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 46.55  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  63 GIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIrPEQRGRFFSLLMM 142
Cdd:cd17333   48 SLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHG 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 261246377 143 QDSAGAVIGALLGSWLLQYDFRLVCATGAILFILCALFNAWLLPAWK 189
Cdd:cd17333  127 FFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFP 173
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
14-161 1.94e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.43  E-value: 1.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  14 FLLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATM 93
Cdd:COG2211  232 LLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 261246377  94 GIA--HEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQ-------RGRFFSLLMMQDSAGAVIGALLGSWLLQY 161
Cdd:COG2211  312 FFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLAL 388
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 39-188 2.72e-05

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 46.09  E-value: 2.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  39 DQMGWAAVMVGIAL---GLRQFIQQGLGIfgGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGtL 115
Cdd:cd17388  235 DRFDWSPTMVGLSLavfGLLHALFQAFVT--GPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGG-I 311

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 261246377 116 FDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLlqYDFRLVCATGAILFILCALFNAWLLPAW 188
Cdd:cd17388  312 AGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGI--FAASPATWPGLAWIIGAALYLICLVLAY 382
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 19-158 3.90e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 45.24  E-value: 3.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  19 NMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIAL---GLRQFIqqgLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGI 95
Cdd:cd17321  177 AFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALlplALAMLV---AAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL 253

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 261246377  96 AHEP---WLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIG-ALLGSWL 158
Cdd:cd17321  254 LGADssvWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGvALLGALL 320
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 63-338 4.20e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 45.29  E-value: 4.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  63 GIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGL--GGTLfdPPRSALVVKLIRPEQRGRFFSLL 140
Cdd:cd17316   53 ALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIgiGGEY--PGASTYVAEFAPSKRRGFALGLL 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 141 MMQDSAGAVIGALLGSWL-----LQYDFRLVCATGAILFILCALFNAWLLPAWklstvrtpvregmrrvmsdkrfVTYVL 215
Cdd:cd17316  131 QSGWALGALLAALVASLLipllsGDWGWRILFLIGALPALLALLLRRRTLLLI----------------------LLWFF 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 216 TLAGYYMLAVqvmlMLP-IMVNDIAGSPAAVKWMYAIEACLSLTLLYPIARWSEKRFRleHRLMAGLLVMSLSMLPI--- 291
Cdd:cd17316  189 ISFGYYGLTT----FLPtYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR--KKTLVIGLILSGILALPlfy 262

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 261246377 292 GMVGNLQQLFTLICAFYIGSVIAEPARETLSASLADARARGSYMGFS 338
Cdd:cd17316  263 LLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLS 309
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 13-176 5.09e-05

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 44.90  E-value: 5.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  13 YFLLIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGI---ALGLRQFIQQGLGIfgGAIADRFGAKPMIVTGMLMRAAG 89
Cdd:cd17331  210 AFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYlmsYAGVLGMVVQGLLV--GPLTKRFGERSLLKLSVALLAIG 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  90 FATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ-YDFRLVCA 168
Cdd:cd17331  288 YLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQaYGFPSFGL 367


                 ....*...
gi 261246377 169 TGAILFIL 176
Cdd:cd17331  368 LGAAINGL 375
PRK12382 PRK12382
putative transporter; Provisional
 24-179 5.38e-05

putative transporter; Provisional


Pssm-ID: 183487 [Multi-domain]  Cd Length: 392  Bit Score: 45.05  E-value: 5.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  24 LGFFVVFPLISIRFVDqMGWAavMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLW 103
Cdd:PRK12382 230 VGFAVIGTFVSLYFAS-KGWA--MAGFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVAL 306

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 261246377 104 FSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLL-MMQDSAGAVIGALLGSWLLQYDFRLVCATGAILFILCAL 179
Cdd:PRK12382 307 AGAALTGAGCSLIFPALGVEVVKRVPSQVRGTALGGYaAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVLGII 383
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 28-187 6.70e-05

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 44.47  E-value: 6.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  28 VVFPLISIRFVDQMGWAAVMVGIALG-------LRQfiqqglgIFGGAIADRFGAKPMIVTGMLM-RAAGFATMGIAHEP 99
Cdd:cd17380   16 VNMPIAIVPMAKEFGWSKTDQGLVLSsffwgyaLTQ-------VLGGYLADRFGGKKVLLLAVALwSLATLLTPLLAYSS 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 100 -WLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLL-QYDFRLVCATGAILFILC 177
Cdd:cd17380   89 lPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLeYYGWPSVFYFFGLLGLLW 168

                        170
                 ....*....|
gi 261246377 178 ALFNAWLLPA 187
Cdd:cd17380  169 ALVWLIYLPP 178
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 64-188 6.83e-05

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 44.53  E-value: 6.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  64 IFGGAIADRFGAKPMIVTGMLmrAAGFATMGI-----AHEPWLLwFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFS 138
Cdd:cd17318   74 IPGGYLAEKYGAKRVLGYSIL--ITALLTLLTplaarGGYGALI-VLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTS 150

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 261246377 139 LLMMQDSAGAVIGALLGSWLLQYD-----FRLvcaTGAILFILCALFNAWLLPAW 188
Cdd:cd17318  151 IAYSGSQFGTVIAMPLSGFLCESLgwpsiFYI---FGGLGLLWCLLWFFLVLPVW 202
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 16-156 7.11e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 44.49  E-value: 7.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  16 LIDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGI 95
Cdd:cd17503  184 LLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAF 263

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 261246377  96 AHEP---WLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLL-MMQDSAGAVIGALLGS 156
Cdd:cd17503  264 LTPDtslWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFnTIRQLGGSIGTALLAT 328
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 20-112 7.78e-05

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 44.52  E-value: 7.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  20 MLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEP 99
Cdd:cd17353   12 MHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISL 91

                         90
                 ....*....|....
gi 261246377 100 WLLWFSC-FLSGLG 112
Cdd:cd17353   92 PLLFLGYgVLGGIG 105
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 67-185 1.41e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 43.79  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  67 GAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSA 146
Cdd:cd17391  261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYL 340

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 261246377 147 GAVIGALLGSWL-LQYDFRLVCATGAILFILCALFNAWLL 185
Cdd:cd17391  341 GNVAGPLLGSAIaAHFGYRAVFVVTALLVLLNAIWSFIFL 380
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
 38-336 2.05e-04

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 43.26  E-value: 2.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  38 VDQMGWAAVMVGIALGLRQFIQQgLGIFGGAIADRFGAK-----PMIVTGMLMRAAGFATMGIA------HEPWLLWFSC 106
Cdd:cd06176   28 IVELGLPATLVGLLIALHYLVAP-LRVWIGHRSDTHPLRgyrrtPYIWLGMLLLALGLALAPFAalllagAAFWLGLALA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 107 FLS----GLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQ--YDFRL--VCATGAILFILCA 178
Cdd:cd06176  107 VLAfllyGIGVGAAGTAFLALLADLTPEERRPRAVTVVWTMLILGIIVTAIVFGRLLDpySPERLiqVFQIVALVALLLA 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 179 LFNAWLL-------PAWKLSTVRTPVREGMRRVMSDK---RFVTYV-LTLAGYYMlavQVMLMLPimvndIAG-----SP 242
Cdd:cd06176  187 LLALWGVerrrsraALAAEEAPPETFREALRLLWASPqarRFFIFLfLSTLALFM---QDVILEP-----FGGevfgmSV 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 243 AAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQ---LFTLICAFYIGSVIAEPARE 319
Cdd:cd06176  259 GETTRLTAIWGGGTLLGMLLAGFLLSRRLGKKRTAALGCLLSALGFLLLALAGLLGNpwlFRPGVFLLGLGNGLFTVGAL 338

                        330
                 ....*....|....*..
gi 261246377 320 TLSASLADARARGSYMG 336
Cdd:cd06176  339 TLMMDLTGEGTAGLFMG 355
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 14-336 5.76e-04

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 41.85  E-value: 5.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  14 FLLIDNMLVVLGFFVVFPLIS---IRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGF 90
Cdd:cd17388    3 FILVTVLLDAMGIGLIMPVLPtllREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  91 ATMGIAHEPWLLWFSCFLSGLGGTLFdPPRSALVVKLIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATG 170
Cdd:cd17388   83 LLMAFAPTLWWLYLGRIIAGITGATG-AVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 171 AILFILCALFNAWLLPAWKLSTVRTPVREGMRRVMSDKRFVTYVLTLAGyyMLAVQVMLML---------PIMVND-IAG 240
Cdd:cd17388  162 AGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLG--LLAVFFLIQLigqvpattwVLFTEDrFDW 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 241 SPAAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPIGMVGNLQQLFTLICAFYIGSvIAEPARET 320
Cdd:cd17388  240 SPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGG-IAGPALQG 318

                        330
                 ....*....|....*.
gi 261246377 321 LSASLADARARGSYMG 336
Cdd:cd17388  319 LLSRQVPENEQGELQG 334
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 47-180 1.10e-03

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 40.64  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  47 MVGIALGlrqfiqqglGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVK 126
Cdd:cd17317   35 FLGVLIG---------SLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 261246377 127 LIRPEQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATG-AILFILCALF 180
Cdd:cd17317  106 IVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLpGLLFLLLLWW 160
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
65-303 1.57e-03

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 40.29  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  65 FGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPW-LLWFSCFLSGLGGtlFDPPRSALVVKLIRPEQRGRFFSLLMMQ 143
Cdd:PRK09874  73 FWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWqFLILRALLGLLGG--FVPNANALIATQVPRNKSGWALGTLSTG 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 144 DSAGAVIGALLGSWLL-QYDFRLVCATGAILFILCALFNAWLLPAwKLSTVRTPVREGMRRVMSDKRFVTYVLTLAgYYM 222
Cdd:PRK09874 151 GVSGALLGPLAGGLLAdSYGLRPVFFITASVLFLCFLVTLFCIRE-NFQPVSKKEMLHMREVVTSLKNPKLVLSLF-VTT 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377 223 LAVQVML-----MLPIMVNDIAGSPAAVKWMYAIEACL-SLTLLYPIARWSE--KRFRLEHRLMAGLLVMSLSMLPIGMV 294
Cdd:PRK09874 229 LIIQVATgsiapILTLYVRELAGNVSNIAFISGMIASVpGVAALLSAPRLGKlgDRIGPEKILITALIFSVLLLIPMSFV 308


                 ....*....
gi 261246377 295 GNLQQLFTL 303
Cdd:PRK09874 309 QTPLQLGIL 317
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 63-161 1.59e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 40.36  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  63 GIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLG-GTLFdPPRSALVVKLIRPEQRGRFFSLLM 141
Cdd:cd17371   51 GILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGfGGEW-AAGAALMAEYVPARHRGKALGYVQ 129

                         90       100
                 ....*....|....*....|
gi 261246377 142 MQDSAGAVIGALLGSWLLQY 161
Cdd:cd17371  130 SGWAVGWLLATLLAALLFPL 149
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 57-180 2.57e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 39.48  E-value: 2.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  57 FIQQGLG-IFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGR 135
Cdd:cd17323   44 VLGFGLGpLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGK 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 261246377 136 FFSLLMMQDSAGAVIGALLGSWLLQY-----DFRLVCATGAILFILCALF 180
Cdd:cd17323  124 AMGVYSLGPLLGPALGPIIGGFITQSlgwrwIFWFLAIISGFCLILIFLF 173
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 62-245 2.87e-03

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 39.73  E-value: 2.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377   62 LGIFGGAIADRFGA-KPMIVTGMLMRAAGFATMGIAH----EPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRF 136
Cdd:pfam05977  61 LSIPAGALADNFDRrKIMLAGQLLLALVSTLLTLLAGlgllSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAA 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  137 FSLLMM----QDSAGAVIGALLGSWllqydfrLVCATGAILFILCALFNAWLLPAWKLSTVRTP---------VREGMRR 203
Cdd:pfam05977 141 VALNSVgyniARSVGPALGGVLLAA-------FGPAFTFALNALSYFAVIAALWRWKRAAPASPlprerifgaVRAGLRF 213

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 261246377  204 VMSDKRFVTYVLTLAGYYMLAVQVMLMLPIMVNDIAGSPAAV 245
Cdd:pfam05977 214 TAMSRELRSVLVRAFAFGLSASAVWALLPLVARDLLDGDAIF 255
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 62-180 3.82e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 39.14  E-value: 3.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  62 LGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLM 141
Cdd:cd17328   50 LSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFY 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 261246377 142 MQDSAGAVIGALLGSWLLQYD------FRLVCATGAILFILCALF 180
Cdd:cd17328  130 FAIPLGSGLGYVVGGLVAQATggwrwaFRVTGVLGVLLAILLLLF 174
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 20-159 4.21e-03

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 38.93  E-value: 4.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  20 MLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEP 99
Cdd:cd17314   12 SAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNS 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 261246377 100 WLLWFSCF-LSGLGGTLFdppRSALVVKLIR--PEQRGRFFSLLMMQDSAGAVIGALLGSWLL 159
Cdd:cd17314   92 FPLSYACFvFIGAGTGIL---YGSAVLVTTQyfPDTKGLALGLPTTGYSLGLVLGSPLLRILW 151
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 57-187 4.79e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 38.74  E-value: 4.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  57 FIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMGIAHEPWLLWFSC----FLSGLGGTlfdpprSALVVKLIRPEQ 132
Cdd:cd17331   46 VLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRlpsvFMHAMQAA------QMVVTDLTDPGE 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 261246377 133 RGRFFSLLMMQDSAGAVIGALLGSWLLQ-YDFRLVCATGAILFILCALFNAWLLPA 187
Cdd:cd17331  120 RAAALGRLGLSYGIGMVVGSFLGGLLTKkFGEQAAALVAAVGSLLSIVLVILLIPS 175
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 64-180 8.37e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 37.92  E-value: 8.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261246377  64 IFGGAIADRFGAKPMIVTGMLMRAAGFATM--GIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLM 141
Cdd:cd17352  236 ILLGLLADKPRIGRLYLYIFTLLILGLSLLafPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVL 315

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 261246377 142 MQDSAGAVIGALLGSWLLQY--DFRLVCATGAILFILCALF 180
Cdd:cd17352  316 LFQGLAALVGPPIAGLLRDYtgDYDAAFYFCGACLLLSGVL 356
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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