|
Name |
Accession |
Description |
Interval |
E-value |
| NagC |
COG1940 |
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ... |
77-387 |
4.58e-49 |
|
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];
Pssm-ID: 441543 [Multi-domain] Cd Length: 306 Bit Score: 168.15 E-value: 4.58e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 77 NSQYRHYIGIEINANGIYLAVTDTIGNLITNSNIKITEYDS-KQINEIIIQLVTETLDKF--SYLEFGALGIAVPGHFDS 153
Cdd:COG1940 1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGAGpEAVLEAIAELIEELLAEAgiSRGRILGIGIGVPGPVDP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 154 KSGHII-SNNVK-WIYFDLA-VIKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKN 230
Cdd:COG1940 81 ETGVVLnAPNLPgWRGVPLAeLLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGAN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 231 FYIGEIGHTVVDLNGPSCECGKRGCLQTYISDTWLINNARFLFenvqgsiiktlveKPEDITLDVVYNAYRLGDGFIIEK 310
Cdd:COG1940 161 GNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELG-------------GAEKLTAEELFAAARAGDPLALEV 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 251815394 311 IESGIDFLTTSIANTLIIYDSKKIFINSQLLN-YPGFSEKVNNLVDNQLqFIPSKNNLDIEFLSFNIFRGAIGAASLA 387
Cdd:COG1940 228 LDEAARYLGIGLANLINLLDPEVIVLGGGVSAaGDLLLEPIREALAKYA-LPPAREDPRIVPASLGDDAGLLGAAALA 304
|
|
| ASKHA_ATPase_ROK_BsXylR-like |
cd24076 |
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ... |
82-388 |
2.04e-34 |
|
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.
Pssm-ID: 466926 [Multi-domain] Cd Length: 303 Bit Score: 129.22 E-value: 2.04e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 82 HYIGIEINANGIYLAVTDTIGNLITNSNIKITEYDS-KQINEIIIQLVTETLDKFSYLEFG--ALGIAVPGHFDSKSGHI 158
Cdd:cd24076 2 AVIGVELGVDYITVVVTDLAGEVLWRREVPLPASDDpDEVLAQLAALIREALAAAPDSPLGilGIGVGVPGLVDSEDGVV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 159 I-SNNVKWIYFDLA-VIKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYIGEI 236
Cdd:cd24076 82 LlAPNLGWRDVPLRdLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASGFAGEI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 237 GHTVVDLNGPSCECGKRGCLQTYISDTWLInnarflfenvqgSIIKTLVEKPEDITLDVVYNAYRLGDGFIIEKIESGID 316
Cdd:cd24076 162 GHMTVDPDGPPCSCGNRGCWETYASERALL------------RAAGRLGAGGEPLSLAELVEAARAGDPAALAALEEVGE 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 251815394 317 FLTTSIANTLIIYDSKKIFINSQLLN-YPGFSEKVNNLVDNQLqFIPSKNNLDIEFLSFNIFRGAIGAASLAV 388
Cdd:cd24076 230 YLGIGLANLVNTFNPELVVLGGALAPlGPWLLPPLRAEVARRA-LPAPARDVRIVVSRLGEDAAALGAAALAI 301
|
|
| ROK |
pfam00480 |
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ... |
84-387 |
4.44e-34 |
|
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.
Pssm-ID: 395384 [Multi-domain] Cd Length: 292 Bit Score: 128.23 E-value: 4.44e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 84 IGIEINANGIYLAVTDTIGNLITNSNIKITEYDSKQ-INEIIIQLVTETLDKFSylEFGALGIAVPGHFDSKSGHIISN- 161
Cdd:pfam00480 1 IGIDIGGTKIAAALFDEEGEILARERVPTPTTTTEEtLVDAIAFFVDSAQRKFG--ELIAVGIGSPGLISPKYGYITNTp 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 162 NVKWIYFDLA-VIKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYIGEIGHTV 240
Cdd:pfam00480 79 NIGWDNFDLVeKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGHIQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 241 VDLNGPSCECGKRGCLQTYISDTwlinnarflfenvqgSIIKTLVEKPEDITLDVVYNAYRLGDGFIIEKIESGIDFLTT 320
Cdd:pfam00480 159 LDPNGPKCGCGNHGCLETIASGR---------------ALEKRYQQKGEDLEGKDIIVLAEQGDEVAEEAVERLARYLAK 223
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 251815394 321 SIANTLIIYDSKKIFINSQLLNYPGFSEKVNNLVDNQLQFIPSKNNLDIEFLSFNIFRGAIGAASLA 387
Cdd:pfam00480 224 AIANLINLFDPQAIVLGGGVSNADGLLEAIRSLVKKYLNGYLPVPPVIIVAASLGDNAGALGAAALA 290
|
|
| ASKHA_NBD_ROK_TM1224-like |
cd24059 |
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ... |
81-392 |
1.25e-33 |
|
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.
Pssm-ID: 466909 [Multi-domain] Cd Length: 305 Bit Score: 127.32 E-value: 1.25e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 81 RHYIGIEINANGIYLAVTDTIGNLITNSNIKITEYDS-KQINEIIIQLVTETLDKFSYLE-FGALGIAVPGHFDSKSGHI 158
Cdd:cd24059 1 PYVIGVEIGRDLLSAVLCDLSGNILAREKYPLDEKENpEEVLEKLYELIDRLLEKENIKSkILGIGIGAPGPLDVEKGII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 159 I--SNNVKWIYFDLA-VIKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYIGE 235
Cdd:cd24059 81 LnpPNFPGWENIPLVeLLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 236 IGHTVVDLNGPSCECGKRGCLQTYISDTWLINNARflfenvqgsiikTLVEKPEDITLDVVyNAYRLGDGFIIEKIESGI 315
Cdd:cd24059 161 IGHTSIDINGPRCSCGNRGCLELYASIPAIEKKAR------------SALGSGRSFQLDIV-EALQKGDPIADEVIEEAA 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 251815394 316 DFLTTSIANTLIIYDSKKIFINSQLLNYPG-FSEKVNNLVDNQLQFIPsKNNLDIEFLSFNIFRGAIGAASLAVYNHF 392
Cdd:cd24059 228 KYLGIGLVNLINLLNPEAIIIGGELIYLGErYLEPIEKEVNSRLFGRN-AREVRILKSSLGEDAPLLGAAALVLNKYF 304
|
|
| ASKHA_ATPase_ROK_CYANR |
cd24073 |
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ... |
81-392 |
1.71e-32 |
|
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466923 [Multi-domain] Cd Length: 304 Bit Score: 124.20 E-value: 1.71e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 81 RHYIGIEINANGIYLAVTDTIGNLITNSNIKITEYDSKQINEIIIQLVTETLDK--FSYLEFGALGIAVPGHFDSKSGHI 158
Cdd:cd24073 1 AYVVGVKLTEDRITAVLTDLRGNVLASHTLPLDSGDPEAVAEAIAEAVAELLAQagLSPDRLLGIGVGLPGLVDAETGIC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 159 I-SNNVKWIYFDLAV-IKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYIGEI 236
Cdd:cd24073 81 RwSPLLGWRDVPLAElLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAGEI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 237 GHTVVDLNGPSCECGKRGCLQTYISDTWLINNARflfenvqgsiikTLVEKPEDITLDVVYNAYRLGDGFIIEKIESGID 316
Cdd:cd24073 161 GHTTVDPDGPPCRCGKRGCLEAYASDPAILRQAR------------EAGLRGEPLTIEDLLAAARAGDPAARAILRRAGR 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 317 FLTTSIANTLIIYDSKKIFIN------SQLLnYPGFSEKVNNLVDNQLQfipSKNNLDIEFLSFNIFrgAIGAASLAVYN 390
Cdd:cd24073 229 ALGLALANLVNLLDPELIIISgegvraGDLL-FEPMREALRAHVFPGLA---SDLELVIHPWGDEAW--ARGAAALALQE 302
|
..
gi 251815394 391 HF 392
Cdd:cd24073 303 FF 304
|
|
| ASKHA_ATPase_ROK_YphH-like |
cd24072 |
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ... |
82-336 |
2.61e-31 |
|
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466922 [Multi-domain] Cd Length: 308 Bit Score: 120.98 E-value: 2.61e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 82 HYIGIEINANGIYLAVTDTIGNLITN-SNIKITEYDSKQINEIIIQLVTETLDKfSYLEFGALGIAVPGHFDSKSGHII- 159
Cdd:cd24072 2 WVLGIVVSPNSLRAQVGNACGELLGEfEYRVITLETPEALIDEIIDCIDRLLKL-WKDRVKGIALAIQGLVDSHKGVSLw 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 160 SNNVKWIYFDLAVI-KQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYIGEIGH 238
Cdd:cd24072 81 SPGAPWRNIEIKYLlEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGIGSAIVIDNKLYIGASSGSGEIGH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 239 TVVDLNGPSCECGKRGCLQTYISDTWLINNARFLFENVQGSiiktlvEKPEDITLDVVYNAYRLGDGFIIEKIESGIDFL 318
Cdd:cd24072 161 TKVNPDGARCDCGRRGCLETVASNSALKRNARVTLKLGPVS------ADPEKLTMEQLIEALEEGEPIATQIFDRAANAI 234
|
250
....*....|....*...
gi 251815394 319 TTSIANTLIIYDSKKIFI 336
Cdd:cd24072 235 GRSLANILNLLNPEQVLL 252
|
|
| ASKHA_ATPase_ROK_SaXylR-like |
cd24077 |
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ... |
82-388 |
3.79e-26 |
|
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.
Pssm-ID: 466927 [Multi-domain] Cd Length: 295 Bit Score: 106.47 E-value: 3.79e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 82 HYIGIEINANGIYLAVTDTIGNLITNSNIKITEYDSKQINEIIIQLVTETLDKFSYLEFGALGIAVPGHfdsksGHIISN 161
Cdd:cd24077 2 YSIGIDLGYNYISLMLTYLDGEIISSKQIKLLDISFENILEILKSIIQELISQAPKTPYGLVGIGIGIH-----GIVDEN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 162 NVKW-IYFDLA------VIKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLfcsffdseHILQNKNFYIG 234
Cdd:cd24077 77 EIIFtPYYDLEdidlkeKLEEKFNVPVYLENEANLSALAERTFSEDYDNLISISIHSGIGA--------GIIINNQLYRG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 235 ------EIGHTVVDLNGPSCECGKRGCLQTYISdtwlinnarflfenvQGSIIKTLVEK--PEDITLDVVYNAYRLGDGF 306
Cdd:cd24077 149 yngfagEIGHMIIVPNGKPCPCGNKGCLEQYAS---------------EKALLKELSEKkgLETLTFDDLIQLYNEGDPE 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 307 IIEKIESGIDFLTTSIANTLIIYDSKKIFINSQLLN-YPGFSEKVNnlvdNQLQfIPSKNNLDIEFLSFNIFRGAIGAAS 385
Cdd:cd24077 214 ALELIDQFIKYLAIGINNIINTFNPEIIIINSSLINeIPELLEKIK----EQLS-SSFNKYVEILISTLGKNATLLGGAA 288
|
...
gi 251815394 386 LAV 388
Cdd:cd24077 289 VAI 291
|
|
| ASKHA_NBD_ROK_TmGLK-like |
cd24064 |
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ... |
84-336 |
7.15e-26 |
|
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466914 [Multi-domain] Cd Length: 301 Bit Score: 106.04 E-value: 7.15e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 84 IGIEINANGIYLAVTDTIGNLITNSNIKiTEYDSKqiNEIIIQLVTETLDKFS-YLEFGALGIAVPGHFDSKSGHII--S 160
Cdd:cd24064 2 IGIDLGGTDTKIGIVDENGDILKKKTID-TKVENG--KEDVINRIAETVNELIeEMELLGIGIGSPGSIDRENGIVRfsP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 161 NNVKWIYFDLA-VIKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYIGEIGHT 239
Cdd:cd24064 79 NFPDWRNFPLVpLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTGVGSGVICHGQLLTGYDGIAAELGHV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 240 VVDLNGPSCECGKRGCLQTYISDTWLINNARFLFENVQGSiiktLVEKPEDITLDVVYNAYRLGDGFIIEKIESGIDFLT 319
Cdd:cd24064 159 IVEPNGPICGCGNRGCVEAFASATAIIRYARESRKRYPDS----LAGESEKINAKHVFDAARKNDPLATMVFRRVVDALA 234
|
250
....*....|....*..
gi 251815394 320 TSIANTLIIYDSKKIFI 336
Cdd:cd24064 235 IAIGGFVHIFNPEIIII 251
|
|
| ASKHA_ATPase_ROK_Lmo0178-like |
cd24071 |
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ... |
81-336 |
6.35e-24 |
|
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466921 [Multi-domain] Cd Length: 312 Bit Score: 100.82 E-value: 6.35e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 81 RHYIGIEINANGIYLAVTDTIGNLITNSNIkitEYDSKQINEIIIQLVTETLDKFS--YLEFGAL---GIAVPGHFDSKS 155
Cdd:cd24071 1 GYIIGVKIEEGYLVLALTDLKGKILEKTRI---PFDHETDPEKVIELIAENIKKLIknKHVEKKLlgiGIAVSGLVDSKK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 156 GHII-SNNVKWIYFDLA-VIKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYI 233
Cdd:cd24071 78 GIVIrSTILGWENVELKkILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNFGGA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 234 GEIGHTVVDLNGPSCECGKRGCLQTYISDTWLINNARFLFENVQGSIIKTLvekpEDITLDVVYNAYRLGDGFIIEKIES 313
Cdd:cd24071 158 GEIGHMTIQPDGRKCYCGQKGCLEAYASFEALVNEIKELTESYPLSLLKEL----EDFEIEKVREAAEEGDSVATELFKK 233
|
250 260
....*....|....*....|...
gi 251815394 314 GIDFLTTSIANTLIIYDSKKIFI 336
Cdd:cd24071 234 AGEYLGIGIKNLINIFNPEAIII 256
|
|
| ASKHA_NBD_ROK_FnNanK-like |
cd24068 |
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ... |
82-386 |
4.33e-22 |
|
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466918 [Multi-domain] Cd Length: 294 Bit Score: 95.32 E-value: 4.33e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 82 HYIGIEINANGIYLAVTDTIGNLITNSNIKITEYDS-KQINEIIIQLVTETLDKFSyleFGALGIAVPGHFDSKSGHII- 159
Cdd:cd24068 1 KILGIDIGGTKIKYGLVDADGEILEKDSVPTPASKGgDAILERLLEIIAELKEKYD---IEGIGISSAGQVDPKTGEVIy 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 160 -SNNVK-WIYFDLA-VIKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYIGEI 236
Cdd:cd24068 78 aTDNLPgWTGTNLKeELEERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCLTLGTGIGGAIILDGRLYRGANGSAGEL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 237 GHTVVDLNGPSCECGKRGCLQTYISDTWLINNARFLFENvqgsiiktlvekpEDITLDVVYNAYRLGDGFIIEKIESGID 316
Cdd:cd24068 158 GHMVVDPGGRPCCCGGKGCLEQYASGTALVRRVAEALGE-------------PGIDGREIFDLADAGDPLAKEVVEEFAE 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 251815394 317 FLTTSIANTLIIYDSKKIFI-----NSQllnyPGFSEKVNNLVDNQLQFiPSKNNLDIEFLSFNIFRGAIGAASL 386
Cdd:cd24068 225 DLATGLANLVHIFDPEVIVIgggisAQG----ELFLEELREELRKLLMP-PLLDATKIEPAKLGNDAGLLGAAYL 294
|
|
| ASKHA_NBD_ROK_ApGLK-like |
cd24063 |
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ... |
83-386 |
3.98e-21 |
|
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466913 [Multi-domain] Cd Length: 308 Bit Score: 92.79 E-value: 3.98e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 83 YIGIEINANGIYLAVTDTIGNLITNSNIKITE-YDSKQINEIIIQLVTETLDKFSYLEFGALGIAVPGHFDSKSGHII-S 160
Cdd:cd24063 2 YVAVDIGGTWIRAGLVDEDGRILLKIRQPTPKtGDPGTVSEQVLGLIETLLSKAGKDSIEGIGVSSAGPLDLRKGTIVnS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 161 NNVKWIYFDLAV-IKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYIGEIGHT 239
Cdd:cd24063 82 PNIKGKEIPLVEpLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGIGGGVIVDGRLLLGKNGNAAEVGHL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 240 VVDLN-GPSCECGKRGCLQTYISDTWLINNARFLFENVQGSIIKTLVE-KPEDITLDVVYNAYRLGDGFIIEKIESGIDF 317
Cdd:cd24063 162 VVDTEsGLKCGCGGYGHWEAFASGRGIPRFAREWAEGFSSRTSLKLRNpGGEGITAKEVFSAARKGDPLALKIIEKLARY 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 251815394 318 LTTSIANTLIIYDSKKIFINSQLLNYPgfSEKVNNLVDNQLQFIPSKNNLDIEFLSFNIFRGAIGAASL 386
Cdd:cd24063 242 NGRGIANVINAYDPELIVIGGSVFNNN--KDILDPLIEYLEKNPAISKGPEIVLSELGDDVGLIGALAL 308
|
|
| ASKHA_NBD_ROK_SgGLK-like |
cd24061 |
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ... |
84-304 |
5.14e-20 |
|
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466911 [Multi-domain] Cd Length: 306 Bit Score: 89.72 E-value: 5.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 84 IGIEINANGIYLAVTDTIGNLItNSNIKITEYDSKQINEIIIQLVTETLDKFSyleFGALGIAVPGHFDSKSGHII-SNN 162
Cdd:cd24061 2 IGVDIGGTKIAAGVVDEEGEIL-ATERVPTPPTADGIVDAIVEAVEELREGHD---VSAVGVAAAGFVDADRATVLfAPN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 163 VKWIYFDL-AVIKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYIGEIGHTVV 241
Cdd:cd24061 78 IAWRNEPLkDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMITVGTGLGGGIVIGGKLLRGAFGIAGEFGHIRV 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 251815394 242 DLNGPSCECGKRGCLQTYISDTWLINNARFLFeNVQGSIIKTLVEKPED--ITLDVVYNAYRLGD 304
Cdd:cd24061 158 VPDGLLCGCGSRGCWEQYASGRALVRYAKEAA-NATPEGAAVLLADGSVdgITGKHISEAARAGD 221
|
|
| ASKHA_ATPase_ROK_NagC |
cd24075 |
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ... |
82-336 |
4.76e-19 |
|
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466925 [Multi-domain] Cd Length: 315 Bit Score: 87.04 E-value: 4.76e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 82 HYIGIEINANGIYLAVTDTIGNLITNSNIKITEYDSKQINEIIIQLVTETLDKFSYL--EFGALGIAVPGHFDSKSGHII 159
Cdd:cd24075 2 HILAVRLGRHDLTLGLYDLSGELLAEHTVPLTALNQEALLSQLIEEIAQFLKSHRRKtqRLIAISITLPGLINPKTGVVH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 160 SN-NVKWIYFDLA-VIKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYIGEIG 237
Cdd:cd24075 82 YMpHIQVKSWPIVeELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEIG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 238 HTVVDLNGPSCECGKRGCLQTYISDTWLINNARFLFEnvQGSIIKTlveKPEDITLDVVYNAYRLGDGFIIEKIESGIDF 317
Cdd:cd24075 162 HIQIEPLGERCHCGNFGCLETVASNAAIEQRVKKLLK--QGYASQL---TLQDCTIKDICQAALNGDQLAQDVIKRAGRY 236
|
250
....*....|....*....
gi 251815394 318 LTTSIANTLIIYDSKKIFI 336
Cdd:cd24075 237 LGKVIAILINLLNPQKIII 255
|
|
| ASKHA_ATPase_ROK_Mlc |
cd24074 |
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ... |
82-394 |
5.46e-19 |
|
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466924 [Multi-domain] Cd Length: 322 Bit Score: 86.98 E-value: 5.46e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 82 HYIGIEINANGIYLAVTDTIGNLITNSNIKITEYDSKQINEIIIQLVTET-LDKFSYLE-FGALGIAVPGHFDSKSG--- 156
Cdd:cd24074 3 QFLSIRIGRGYITLALRDLNGRLLAEERYPLPAKDNDPFLDRLLESISEFfSRHQKKLErLTAIAITLPGIIDPESGivh 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 157 HIISNNVKwiyfDLAV---IKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYI 233
Cdd:cd24074 83 RLPFYDIK----NLPLgeaLEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHAGSSRL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 234 GEIGHTVVDLNGPSCECGKRGCLQTYISDTWLINNARFLFENVQGSIIktlveKPEDITLDVVYNAYRLGDGFIIEKIES 313
Cdd:cd24074 159 GELGHTQIDPYGKRCYCGNHGCLETVASIPAILEQANQLLEQSPDSML-----HGQPISIESLCQAALAGDPLAQDIIIQ 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 314 GIDFLTTSIANTLIIYDSKKIFINSQLLN-----YPGFSEKVnnlvdnQLQFIPS-KNNLDIEFLSFNiFRGAIGAASL- 386
Cdd:cd24074 234 VGRHLGRILAILVNLFNPEKILIGSPLNNaaeilFPALSQSI------RQQSLPAySQHLQIESTKFY-NDGTMPGAALi 306
|
330
....*....|
gi 251815394 387 --AVYNHFIL 394
Cdd:cd24074 307 kdALYDGSLL 316
|
|
| ASKHA_ATPase_ROK |
cd23763 |
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ... |
84-241 |
8.46e-19 |
|
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.
Pssm-ID: 466849 [Multi-domain] Cd Length: 239 Bit Score: 84.82 E-value: 8.46e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 84 IGIEINANGIYLAVTDTIGNLITNSNIKITEYDSKQ-INEIIIQLVTETLDKFSYLE-FGALGIAVPGHFDSKSGHII-S 160
Cdd:cd23763 1 IGIDIGGTKIRAALVDLDGEILARERVPTPAEEGPEaVLDRIAELIEELLAEAGVRErILGIGIGVPGPVDPETGIVLfA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 161 NNVKWIY-FDLA-VIKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYIGEIGH 238
Cdd:cd23763 81 PNLPWWKnVPLReLLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYITLGTGIGGGIIIDGKLYRGANGAAGEIGH 160
|
...
gi 251815394 239 TVV 241
Cdd:cd23763 161 ITV 163
|
|
| ASKHA_NBD_ROK_BsGLK-like |
cd24062 |
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ... |
83-336 |
5.57e-17 |
|
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466912 [Multi-domain] Cd Length: 311 Bit Score: 80.80 E-value: 5.57e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 83 YIGIEINANGIYLAVTDTIGNLITNSNIKI-TEYDSKQINEIIIQLVTETLDKFSY--LEFGALGIAVPGHFDSKSGHII 159
Cdd:cd24062 2 IVGIDVGGTTIKMAFLTQEGEIVQKWEIPTnKLEGGENIITDIAESIQQLLEELGYskEDLIGIGVGVPGPVDVETGTVE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 160 -SNNVKWIYFDLAVIKQSI-SIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYIGEIG 237
Cdd:cd24062 82 vAVNLGWKNFPLKDKLEALtGIPVVIDNDANAAALGEMWKGAGQGAKDLVFITLGTGVGGGVIANGKIVHGANGAAGEIG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 238 H-TVVDLNGPSCECGKRGCLQTYISDTWLINNARFLFENVQGSIIKTLVEKPEDITLDVVYNAYRLGDGFIIEKIESGID 316
Cdd:cd24062 162 HiTVNPEGGAPCNCGKTGCLETVASATGIVRIAREELEEGKGSSALRILALGGELTAKDVFEAAKAGDELALAVVDTVAR 241
|
250 260
....*....|....*....|
gi 251815394 317 FLTTSIANTLIIYDSKKIFI 336
Cdd:cd24062 242 YLGLALANLANTLNPEKIVI 261
|
|
| ASKHA_NBD_ROK_GNE |
cd24060 |
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ... |
141-386 |
3.86e-16 |
|
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.
Pssm-ID: 466910 [Multi-domain] Cd Length: 305 Bit Score: 78.23 E-value: 3.86e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 141 GALGIAVPGHFDSKSGhIISNNVK----WIYFDL-AVIKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGL 215
Cdd:cd24060 61 LGVGISTGGRVNPREG-IVLHSTKliqeWSSVDLrTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTGI 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 216 FCSFFDSEHILQNKNFYIGEIGHTVVDLNGPSCECGKRGCLQTYISDTWLINNARFLFEN----VQGSIIKtlveKPEDI 291
Cdd:cd24060 140 GGGIILNHELIHGSSFCAAELGHIVVSLDGPDCMCGSHGCVEAYASGMALQREAKKLHDEdlllVEGMSVT----NDEEV 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 292 TLDVVYNAYRLGDGFIIEKIESGIDFLTTSIANTLIIYDSKKIFINSQLLNYpgFSEKVNNLVDNQLqfIPSKNNLDIeF 371
Cdd:cd24060 216 TAKHLIQAAKLGNAKAQKILRTAGTALGLGIVNILHTLNPSLVILSGVLASH--YENIVKDVIAQRA--LPSVQNVDV-V 290
|
250
....*....|....*
gi 251815394 372 LSFNIFRGAIGAASL 386
Cdd:cd24060 291 VSDLVDPALLGAASM 305
|
|
| ASKHA_NBD_ROK-like |
cd24152 |
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ... |
83-336 |
1.17e-13 |
|
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466988 [Multi-domain] Cd Length: 286 Bit Score: 70.67 E-value: 1.17e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 83 YIGIEINANGIYLAVTDTIGNLITNSNIKITEYDSKQINEIIIQLVTETLDKFSylefgALGIAVPGHFDSKSGHII--S 160
Cdd:cd24152 2 YLVFDIGGTFIKYALVDENGNIIKKGKIPTPKDSLEEFLDYIKKIIKRYDEEID-----GIAISAPGVIDPETGIIYggG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 161 NNVKWIYFDLA-VIKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYIGEIGHT 239
Cdd:cd24152 77 ALPYLKGFNLKeELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSYL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 240 VVDLNGPScecgkrgclQTYISDTWLINNARFLFENVQGSIIKTLVEkpeditldvVYNAYRLGDGFIIEKIESGIDFLT 319
Cdd:cd24152 157 LTDDDDKD---------LLFFSGLASMFGLVKRYNKAKGLEPLDGEE---------IFEKYAKGDEAAKKILDEYIRNLA 218
|
250
....*....|....*..
gi 251815394 320 TSIANTLIIYDSKKIFI 336
Cdd:cd24152 219 KLIYNIQYILDPEVIVI 235
|
|
| ASKHA_NBD_ROK_TtHK-like |
cd24065 |
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ... |
141-273 |
3.74e-13 |
|
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466915 [Multi-domain] Cd Length: 289 Bit Score: 69.28 E-value: 3.74e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 141 GALGIAVPGHFDSKSGHII--SNNVKWIYFDLA-VIKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFC 217
Cdd:cd24065 57 EAVGLGVPGPLDFRRGRVRfaPNIPGLTDFPIRrGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVYVTISTGIGG 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 251815394 218 SFFDSEHILQNKNFYIGEIGHTVVDLNGPSCECGKRGCLQTYISDTWLINNARFLF 273
Cdd:cd24065 137 GLVLGGRVLRGRHGQAGEIGHTTVLPGGPMCGCGLVGCLEALASGRALARDASFAY 192
|
|
| PRK09698 |
PRK09698 |
D-allose kinase; Provisional |
84-387 |
4.93e-13 |
|
D-allose kinase; Provisional
Pssm-ID: 182034 [Multi-domain] Cd Length: 302 Bit Score: 69.24 E-value: 4.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 84 IGIEINANGIYLAVTDTIGNLITNSNIKITEYDSKQINEIIIQLVTETLDKFSYlEFGALGIAVPGHFDSKSGHIISN-N 162
Cdd:PRK09698 7 LGIDMGGTHIRFCLVDAEGEILHCEKKRTAEVIAPDLVSGLGEMIDEYLRRFNA-RCHGIVMGFPALVSKDRRTVISTpN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 163 VKWIYFDL----AVIKQSISIPIFLENNINcMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYIGEIGH 238
Cdd:PRK09698 86 LPLTALDLydlaDKLENTLNCPVFFSRDVN-LQLLWDVKENNLTQQLVLGAYLGTGMGFAVWMNGAPWTGAHGVAGELGH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 239 TVVDLNGPSCECGKRGCLQTYISDTWLINNARflfenvqgsiiktlvEKPEDITLDVVYNayRLGDGFIIEKIesgIDFL 318
Cdd:PRK09698 165 IPLGDMTQHCGCGNPGCLETNCSGMALRRWYE---------------QQPRDYPLSDLFV--HAGDHPFIQSL---LENL 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 319 TTSIANTLIIYDSKKIFINSQLLNYPGFS-EKVNNLVDNQLQFIPSKNNLDIEFLSFNIFRGAIGAASLA 387
Cdd:PRK09698 225 ARAIATSINLFDPDAIILGGGVMDMPAFPrETLIAMIQKYLRKPLPYEVVRFIYASSSDFNGAQGAAILA 294
|
|
| ASKHA_NBD_ROK_AlsK |
cd24070 |
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ... |
83-387 |
2.70e-12 |
|
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466920 [Multi-domain] Cd Length: 293 Bit Score: 66.80 E-value: 2.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 83 YIGIEINANGIYLAVTDTIGNLItNSNIKITE--YDSKQINEIIIQLVTETLDKFSYlEFGALGIAVPGHFDSKSGHIIS 160
Cdd:cd24070 3 VLGIDIGGTNIRIGLVDEDGKLL-DFEKVPSKdlLRAGDPVEVLADLIREYIEEAGL-KPAAIVIGVPGTVDKDRRTVIS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 161 -------NNVkwiyfDLA-VIKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPGLFCSFFDSEHILQNKNFY 232
Cdd:cd24070 81 tpnipglDGV-----NLAdILENKLGIPVILERDVNLLLLYDMRAGNLDDEGVVLGFYIGTGIGNAILINGKPLRGKNGV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 233 IGEIGHTVVDLNGPSCECGKRGCLQTYISDTWLINNARflfENvqgsiiktlveKPEDITLDVVYNAyrlGDGFIIEKIe 312
Cdd:cd24070 156 AGELGHIPVYGNGKPCGCGNTGCLETYASGRALEEIAE---EH-----------YPDTPILDIFVDH---GDEPELDEF- 217
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 251815394 313 sgIDFLTTSIANTLIIYDSKKIFINSQLLNYPGFS-EKVNNLVDNQLQFIPSKNNLDIEFLSFNIFRGAIGAASLA 387
Cdd:cd24070 218 --VEDLALAIATEINILDPDAVILGGGVIDMKGFPrETLEEYIRKHLRKPYPADNLKIIYAELGPEAGVIGAAIYA 291
|
|
| ASKHA_NBD_ROK_EcNanK-like |
cd24069 |
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ... |
138-350 |
1.08e-11 |
|
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466919 [Multi-domain] Cd Length: 283 Bit Score: 65.00 E-value: 1.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 138 LEFGALGIAVPGHFDSKSGHIISNNVKWIY--FDLAV-IKQSISIPIFLENNINCMAIGSYLFHPESSPEQFLFIHIGPG 214
Cdd:cd24069 50 GQFDRVAVASTGIIRDGVLTALNPKNLGGLsgFPLADaLQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFITVSTG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 215 LFCSFFDSEHILQNKNFYIGEIGHTVVDLNGPSCECGKRGCLQTYISDTWLinnARflfenvQGS-IIKTLVEKPEditl 293
Cdd:cd24069 130 VGGGLVLNGQLLTGPNGLAGHIGHTLADPPGPVCGCGRRGCVEAIASGTAI---AA------AASeILGEPVDAKD---- 196
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 251815394 294 dvVYNAYRLGDGFIIEKIESGIDFLTTSIANTLIIYDSKKIFINSQLLNYPGFSEKV 350
Cdd:cd24069 197 --VFERARSGDEEAARLIDRAARALADLIADLKATLDLDCVVIGGSVGLAEGFLERV 251
|
|
| PRK13310 |
PRK13310 |
N-acetyl-D-glucosamine kinase; Provisional |
83-348 |
8.66e-09 |
|
N-acetyl-D-glucosamine kinase; Provisional
Pssm-ID: 183967 [Multi-domain] Cd Length: 303 Bit Score: 56.15 E-value: 8.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 83 YIGIEINANGIYLAVTDTIGNLITNSNIKITEYDSKQINEIIIQLVTETLDKFSylEFGALGIAVPGHFDSKSGHIISNN 162
Cdd:PRK13310 2 YYGFDIGGTKIELGVFNEKLELQWEERVPTPRDSYDAFLDAVCELVAEADQRFG--CKGSVGIGIPGMPETEDGTLYAAN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 163 V-----KWIYFDL-AVIKQSISIpiflENNINCMAIgSYLFHPESSPEQF-LFIHIGPGLFCSFFDSEHILQNKNFYIGE 235
Cdd:PRK13310 80 VpaasgKPLRADLsARLGRDVRL----DNDANCFAL-SEAWDDEFTQYPLvMGLILGTGVGGGLVFNGKPISGRSYITGE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 236 IGHT--------VVDLNGP--SCECGKRGCLQTYISdtwlinnAR---FLFENVQGSIIKTlvekPEDITldvvynAYRL 302
Cdd:PRK13310 155 FGHMrlpvdaltLLGWDAPlrRCGCGQKGCIENYLS-------GRgfeWLYQHYYGEPLQA----PEIIA------LYYQ 217
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 251815394 303 GDGFIIEKIESGIDFLTTSIANTLIIYDSKKIFINSQLLNYPGFSE 348
Cdd:PRK13310 218 GDEQAVAHVERYLDLLAICLGNILTIVDPHLVVLGGGLSNFDAIYE 263
|
|
| PRK13311 |
PRK13311 |
N-acetyl-D-glucosamine kinase; Provisional |
83-261 |
2.31e-08 |
|
N-acetyl-D-glucosamine kinase; Provisional
Pssm-ID: 106271 [Multi-domain] Cd Length: 256 Bit Score: 54.65 E-value: 2.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 83 YIGIEINANGIYLAVTDTIGNLITNSNIKITEYDSKQINEIIIQLvTETLDKFSYLEfGALGIAVPGHFDSKSGHIISNN 162
Cdd:PRK13311 2 YYGFDMGGTKIELGVFDENLQRIWHKRVPTPREDYPQLLQILRDL-TEEADTYCGVQ-GSVGIGIPGLPNADDGTVFTAN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 163 V-----KWIYFDLAVIKQSisiPIFLENNINCMAIgSYLFHPE-SSPEQFLFIHIGPGLFCSFFDSEHILQNKNFYIGEI 236
Cdd:PRK13311 80 VpsamgQPLQADLSRLIQR---EVRIDNDANCFAL-SEAWDPEfRTYPTVLGLILGTGVGGGLIVNGSIVSGRNHITGEF 155
|
170 180 190
....*....|....*....|....*....|....*
gi 251815394 237 GH-----TVVDLNGPS-----CECGKRGCLQTYIS 261
Cdd:PRK13311 156 GHfrlpvDALDILGADiprvpCGCGHRGCIENYIS 190
|
|
| ASKHA_NBD_ROK_NAGK |
cd24057 |
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ... |
141-330 |
2.57e-07 |
|
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466907 [Multi-domain] Cd Length: 298 Bit Score: 51.85 E-value: 2.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 141 GALGIAVPGHFDSKSGHIISNNV-----KWIYFDLAvikQSISIPIFLENNINCMAIgSYLFHPESSPEQFLF-IHIGPG 214
Cdd:cd24057 58 GPVGIGIPGVIDPEDGTLITANIpaakgRPLRADLS---ARLGRPVRIDNDANCFAL-SEAWDGAGRGYPSVFgLILGTG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 215 LFCSFFDSEHILQNKNFYIGEIGHT--VVDLNGP-------SCECGKRGCLQTYISDTWLINNARFLFEnvqgsiiKTLv 285
Cdd:cd24057 134 VGGGLVVNGRLVGGRSGIAGEWGHGplPADALLLgydlpvlRCGCGQTGCLETYLSGRGLERLYAHLYG-------EEL- 205
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 251815394 286 eKPEDITldvvyNAYRLGDGFIIEKIESGIDFLTTSIANTLIIYD 330
Cdd:cd24057 206 -DAPEII-----AAWAAGDPQAVAHVDRWLDLLAGCLANILTALD 244
|
|
| ASKHA_NBD_ROK_EcFRK-like |
cd24066 |
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ... |
139-261 |
1.27e-05 |
|
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466916 [Multi-domain] Cd Length: 294 Bit Score: 46.43 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 139 EFGALGIAVPGHFDSKSGHIISNNVKWIY---FDlAVIKQSISIPIFLENNINCMAIgSYLFHPESSPEQFLFIHI---- 211
Cdd:cd24066 55 APATVGIGTPGSISPRTGLVKNANSTWLNgkpLK-ADLEARLGRPVRIENDANCFAL-SEATDGAGAGAGVVFGVIlgtg 132
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 251815394 212 -GPGLFcsfFDSEhILQNKNFYIGEIGHTVVD------LNGPSCECGKRGCLQTYIS 261
Cdd:cd24066 133 vGGGIV---VNGR-VLTGANGIAGEWGHNPLPwpdedeLPGPPCYCGKRGCVETFLS 185
|
|
| PRK05082 |
PRK05082 |
N-acetylmannosamine kinase; Provisional |
174-255 |
3.50e-05 |
|
N-acetylmannosamine kinase; Provisional
Pssm-ID: 235338 [Multi-domain] Cd Length: 291 Bit Score: 45.29 E-value: 3.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251815394 174 KQSIS----IPIFLENNINCMAIGSYLFHPESSpEQFLFIHIGPGLFCSFFDSEHILQNKNFYIGEIGHTVVDLNGPSCE 249
Cdd:PRK05082 89 VQTLEqltdLPTIALNDAQAAAWAEYQALPDDI-RNMVFITVSTGVGGGIVLNGKLLTGPGGLAGHIGHTLADPHGPVCG 167
|
....*.
gi 251815394 250 CGKRGC 255
Cdd:PRK05082 168 CGRRGC 173
|
|
| |
