|
Name |
Accession |
Description |
Interval |
E-value |
| uvrC |
PRK00558 |
excinuclease ABC subunit UvrC; |
55-677 |
0e+00 |
|
excinuclease ABC subunit UvrC;
Pssm-ID: 234792 [Multi-domain] Cd Length: 598 Bit Score: 924.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 55 ELIGEFVKRLPNSPGVYRMFNAEGDVLYVGKARSLKKRVNNYAVGRVHSNRIAQMVRQTANMEFVTTRTETEALLLEANL 134
Cdd:PRK00558 2 EFLKEKLKTLPDSPGVYRMKDANGTVIYVGKAKNLKNRVRSYFRKSHDSPKTRAMVSEIADIEYIVTRSETEALLLENNL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 135 IKRLRPRFNVLLRDDKSFPYILITGDHRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTDSVFETRT 214
Cdd:PRK00558 82 IKKYKPRYNVLLRDDKSYPYIKITTNEEFPRLAITRGVAKDKGRYFGPYPSAGAVRETLDLLQKLFPLRTCEDSVFKNRK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 215 RPCLLYQIKRCSGPCTHEVSDGGYGELVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSHQG 294
Cdd:PRK00558 162 RPCLLYQIGRCLAPCVGLISKEEYAELVDEAKLFLSGKTDEVLKELEEKMEEASENLEFERAARYRDQIQALRRVQEKQK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 295 INPAGVEEADVFAIHHEGGISCIQVFFFRTGQNWGNRAYFPKADPQlSSAEVLNSFLAQFYDDKPVPKQIMLSQTVEELE 374
Cdd:PRK00558 242 VSLKDGEDADVIAIAVDGGWACVQVFFVRGGKLLGRRSYFPKVSET-ELEEILEAFLGQFYLQKSIPKEILVPHELDDEE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 375 LLAAAlseKAGHKVSMLVPQRGEKRDLVDHVVGNAREAHGRKLAETASQSRLLEGFKETFGLAYAPQRIEIYDNSHIMGT 454
Cdd:PRK00558 321 LAEAL---LAGRKVKIRVPQRGDKKELLELAEKNAREALERKLSDQSTQQQALEELAELLGLPEPPYRIECFDISHIQGT 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 455 NAVGGMVVAGPEGFVKNQYRKFNIKStdITPGDDFGMMKEVMTRRFSRLIKEEGIpdrtaqvatpdaadmpfptWPDVIL 534
Cdd:PRK00558 398 ATVASMVVFEDGGPDKSEYRRYNIKG--VTGGDDYAAMREVLTRRYSRLLKEFGP-------------------LPDLIL 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 535 IDGGQGQMTAVRAILAELGITdsVTAIGIAKGVDRDAGRER-FFPPGRESFTLPPRDPVLYFIQRMRDEAHRFAIGSHRA 613
Cdd:PRK00558 457 IDGGKGQLNAAKEVLEELGLD--IPVVGLAKGDKRKAGTEElFFPGEPEPIILPPDSPALYLLQRIRDEAHRFAITFHRK 534
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115256001 614 RRKKEMIKNPLDEIGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVEGISEAVARQVYNHFHDD 677
Cdd:PRK00558 535 KRSKARLTSALDDIPGIGPKRRKALLKHFGSLKAIKEASVEELAKVPGISKKLAEAIYEALHKK 598
|
|
| UvrC |
COG0322 |
Excinuclease UvrABC, nuclease subunit [Replication, recombination and repair]; |
53-677 |
0e+00 |
|
Excinuclease UvrABC, nuclease subunit [Replication, recombination and repair];
Pssm-ID: 440091 [Multi-domain] Cd Length: 603 Bit Score: 901.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 53 GAELIGEFVKRLPNSPGVYRMFNAEGDVLYVGKARSLKKRVNNYAVGRVHSNRIAQMVRQTANMEFVTTRTETEALLLEA 132
Cdd:COG0322 2 DPFDLKEKLKTLPTSPGVYLMKDANGEVIYVGKAKNLKNRVSSYFQKSDLSPKTRRMVSEIADIEYIVTDTETEALLLEN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 133 NLIKRLRPRFNVLLRDDKSFPYILITgDHRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTDSVFET 212
Cdd:COG0322 82 NLIKKHKPRYNILLKDDKSYPYIKIT-NEEFPRIFVTRGVKKDGGRYFGPYPSAGAVRETLDLLQKLFPLRTCSDSLFKN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 213 RTRPCLLYQIKRCSGPCTHEVSDGGYGELVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSH 292
Cdd:COG0322 161 RSRPCLLYQIGRCSAPCVGLISEEEYREDVEQARRFLEGKTKELIKELEEKMEEAAEELEFERAARLRDQIRALEKVQEK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 293 QGINPAGVEEADVFAIHHEGGISCIQVFFFRTGQNWGNRAYFPKADPQLSSAEVLNSFLAQFYDDKP-VPKQIMLSQTVE 371
Cdd:COG0322 241 QKVVLPDGGDADVIAIARDGGEACVQVFFVRGGRLIGRRSFFLEKVLDEDDEELLEAFLAQYYLDRPsIPKEILVPEELE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 372 ELELLAAALSEKAGHKVSMLVPQRGEKRDLVDHVVGNAREAHGRKLAET----ASQSRLLEGFKETFGLAYAPQRIEIYD 447
Cdd:COG0322 321 DAELLEEWLSERRGRKVKIRVPQRGEKKKLLELAEKNAREALERKLAERerdeARQERALEELAEALGLPELPRRIECFD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 448 NSHIMGTNAVGGMVVAGPEGFVKNQYRKFNIKStdITPGDDFGMMKEVMTRRFSRLIKEEGipdrtaqvatpdaadmpfp 527
Cdd:COG0322 401 ISHIQGTNTVASMVVFEDGKPDKSDYRRFKIKT--VEGGDDYASMREVLTRRYKRLLEEDE------------------- 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 528 TWPDVILIDGGQGQMTAVRAILAELGITDsVTAIGIAKgvdRDagRERFFPPGRESFTLPPRDPVLYFIQRMRDEAHRFA 607
Cdd:COG0322 460 PLPDLILIDGGKGQLNAAREVLEELGLDD-IPVIGLAK---RD--EELFLPGDSEPIILPRNSPALYLLQRIRDEAHRFA 533
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 608 IGSHRARRKKEMIKNPLDEIGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVEGISEAVARQVYNHFHDD 677
Cdd:COG0322 534 ITFHRKLRSKARLKSVLDEIPGIGPKRRKALLKHFGSLKAIKEASVEELAAVPGISKKLAEAIYEYLHKE 603
|
|
| uvrC |
TIGR00194 |
excinuclease ABC, C subunit; This family consists of the DNA repair enzyme UvrC, an ABC ... |
59-655 |
0e+00 |
|
excinuclease ABC, C subunit; This family consists of the DNA repair enzyme UvrC, an ABC excinuclease subunit which interacts with the UvrA/UvrB complex to excise UV-damaged nucleotide segments. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 272953 [Multi-domain] Cd Length: 574 Bit Score: 556.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 59 EFVKRLPNSPGVYRMFNAEGDVLYVGKARSLKKRVNNYAVGRvHSNRIAQMVRQTANMEFVTTRTETEALLLEANLIKRL 138
Cdd:TIGR00194 3 EKLKNLPDKPGCYLMKDRNGQVLYVGKAKNLKKRVSSYFREN-NSAKTQALVKQIADIEYILTKNENEALILEANLIKQY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 139 RPRFNVLLRDDKSFPYILITGDhRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTDSvfeTRTRPCL 218
Cdd:TIGR00194 82 QPRYNVLLKDDKGYPYIYITHE-KYPRLLITRKLKQDKGKYFGPFTNAFALRETLDLLLKLFPLRKCAKH---NRNRPCL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 219 LYQIKRCSGPCTHEVSDGGYGELVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSHQGINPA 298
Cdd:TIGR00194 158 YYQIGRCLGPCVKEITEEEYQQIVEKIELFFNGRPQEVIKELEQKMEKASENLEFEEAARIRDQIAAVRELNEKQHVSLT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 299 GVEEADVFAIHHEGGISCIQVFFFRTGQNWGNRAYFPKAdPQLSSAEVLNSFLAQFY----DDKPVPKQIMLSQTVEELE 374
Cdd:TIGR00194 238 DLIDLDIIAVAFDGNVAAIQVFFIRQGKLIGRDQFDFSL-PGTDLDELVETFLIQFYqqgyQNRLIPSEILVSLSLEDLK 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 375 LLAAALSEKAGHKVSMLVPQRGEKRDLVDHVVGNAREAHGRKLAETASQSRLLEGFKETFGLaYAPQRIEIYDNSHIMGT 454
Cdd:TIGR00194 317 LLEDLLSEQRGRKINVHQPKKGDKKKLLELAIKNAKYALKQKWTQFERKTQALEDLASLLNL-PKIKRIEIFDISHIDGS 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 455 NAVGGMVVAGPEGFVKNQYRKFNIKStdITPGDDFGMMKEVMTRRFSRLIKEEGIPdrtaqvatpdaadmpfptWPDVIL 534
Cdd:TIGR00194 396 QTVGSMVVFEDGKPLKASYRRYNINS--ITGGDDYAAMREVLRRRYSSIQKKNNLP------------------LPDLIL 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 535 IDGGQGQMTAVRAILAELGITDSVTAIGIAKgVDRDAGRErFFPPGRESFTLPPRDPVLYFIQRMRDEAHRFAIGSHRAR 614
Cdd:TIGR00194 456 IDGGKGQLNAALEVLKSLGVVNKPIVIGLAK-AKRHETDI-FLIGDKQGINIDLNSPALQLLQHIRDEAHRFAISFHRKK 533
|
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 115256001 615 RKKEMIKNPLDEIGGIGPSRKRALLQHFGTAKAVSRAALSD 655
Cdd:TIGR00194 534 RLKASLQSPLLKIPGVGEKRVQKLLKYFGSLKGIKKASVEE 574
|
|
| UvrC_RNaseH_dom |
pfam08459 |
UvrC RNAse H endonuclease domain; This domain is found in the C subunits of the bacterial and ... |
431-607 |
1.76e-67 |
|
UvrC RNAse H endonuclease domain; This domain is found in the C subunits of the bacterial and archaeal UvrABC system which catalyzes nucleotide excision repair in a multi-step process. UvrC catalyzes the first incision on the fourth or fifth phosphodiester bond 3' and on the eighth phosphodiester bond 5' from the damage that is to be excised. The domain described here represents the RNAse H endonuclease domain, located at the C-terminal, between the UvrBC and the (HhH)2 domains, nearby the N-terminal of the HhH. Despite the lack of sequence homology, the endonuclease domain has an RNase H-like fold, which is characteriztic of enzymes with nuclease or polynucleotide transferase activities. RNase H-related enzymes typically contain a highly conserved carboxylate triad, usually DDE, in their catalytic centre. However, instead of a third carboxylate, UvrC of Thermotoga maritima was found to contain a highly conserved histidine (H488) on helix-4 in close proximity to two aspartates.
Pssm-ID: 462484 [Multi-domain] Cd Length: 150 Bit Score: 217.70 E-value: 1.76e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 431 KETFGLAYAPQRIEIYDNSHIMGTNAVGGMVVAGPEGFVKNQYRKFNIKSTdiTPGDDFGMMKEVMTRRFSRLIKEEGIp 510
Cdd:pfam08459 1 QEALGLPKLPRRIECFDISHIQGTDTVASMVVFEDGKPDKSDYRRFNIKTT--VGPDDYASMREVLTRRFSRLLEEFGP- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 511 drtaqvatpdaadmpfptWPDVILIDGGQGQMTAVRAILAELGItdSVTAIGIAKGVDRDAGRERffppGRESFTLPPRD 590
Cdd:pfam08459 78 ------------------LPDLILIDGGKGQLNAALEVLEELGL--DIPVIGLAKDDKHKIDTDG----REEEIILPRDS 133
|
170
....*....|....*..
gi 115256001 591 PVLYFIQRMRDEAHRFA 607
Cdd:pfam08459 134 PALHLLQRIRDEAHRFA 150
|
|
| GIY-YIG_UvrC_Cho |
cd10434 |
Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar ... |
64-144 |
1.08e-39 |
|
Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; UvrC is essential for nucleotide excision repair (NER). The N-terminal catalytic GIY-YIG domain of UvrC (also known as Uri domain) is responsible for the 3' incision reaction and the C-terminal half of UvrC, consisting of an UvrB-binding domain (UvrBb), EndoV-like nuclease domain and a helix-hairpin-helix (HhH) DNA-binding domain, contains the residues involved in 5' incision. The N- and C-terminal regions are joined by a common Cys-rich domain containing four conserved Cys residues. Besides UvrC, protein Cho (UvrC homolog) serves as a second endonuclease in E. coli NER. Cho contains GIY-YIG motif followed by a Cys-rich region and shares sequence homology with the N-terminal half of UvrC. It is capable of incising the DNA at the 3' side of a lesion in the presence of the UvrA and UvrB proteins during NER. The C-terminal half of Cho is a unique uncharacterized domain, which is distinct from that of UvrC. Moreover, unlike UvrC, Cho does not require the UvrC-binding domain of UvrB for the 3' incision reaction, which might cause the shift in incision position and the difference in incision efficiencies between Cho and UvrC on different damaged substrates. Due to this, the range of NER in E. coli can be broadened by combining action of Cho and UvrC. This family also includes many uncharacterized epsilon proofreading subunits of DNA polymerase III, which have an additional N-terminal ExoIII domain and a 3'-5' exonuclease domain homolog, fused to an UvrC-like region or a Cho-like region. The UvrC-like region includes a GIY-YIG motif, followed by a Cys-rich region, and an UvrB-binding domain (UvrBb), but lacks the EndoV-like nuclease domain and the helix-hairpin-helix (HhH) DNA-binding domain. The Cho-like region consists of a GIY-YIG motif, followed by the Cys-rich region, and the unique uncharacterized domain presenting in the C-terminal half of Cho. Some family members may not carry the Cys-rich region. This family also includes a specific Cho-like protein from G. violaceus, which possesses only UvrBb domain at the C-terminus, but lacks the additional N-terminal ExoIII domain. The oother two remote homologs of UvrC, Bacillus-I and -II, are included in this family as well. Both of them contain a GIY-YIG domain, but no Cys-rich region. Moreover, the whole C-terminal region of Bacillus-I is replaces by an unknown domain, and Bacillus-II possesses another unknown N-terminal extension.
Pssm-ID: 198381 [Multi-domain] Cd Length: 81 Bit Score: 140.31 E-value: 1.08e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 64 LPNSPGVYRMFNAEGDVLYVGKARSLKKRVNNYAVGRVHSNRIAQMVRQTANMEFVTTRTETEALLLEANLIKRLRPRFN 143
Cdd:cd10434 1 LPDSPGVYLFKDADGEVLYVGKAKNLRKRVSSYFTGERHSPKTRRLVEEIRDIEYIVTDSELEALLLEANLIKKYKPRYN 80
|
.
gi 115256001 144 V 144
Cdd:cd10434 81 I 81
|
|
| GIYc |
smart00465 |
GIY-YIG type nucleases (URI domain); |
68-148 |
5.59e-14 |
|
GIY-YIG type nucleases (URI domain);
Pssm-ID: 214677 [Multi-domain] Cd Length: 84 Bit Score: 67.45 E-value: 5.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 68 PGVYRMFNAEGDVLYVGKARSLKKRVNNYAVGRVHSNRIAQMV-RQTANMEFVTTRTETE-ALLLEANLIKRLRPRFNVL 145
Cdd:smart00465 2 PGVYYITNKKNGKLYVGKAKNLRNRLKRHFSGSRKGRLLIDALlKYGGNFEFIILESFDEsALELEKYLIKEYKPKYNLL 81
|
...
gi 115256001 146 LRD 148
Cdd:smart00465 82 LKG 84
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| uvrC |
PRK00558 |
excinuclease ABC subunit UvrC; |
55-677 |
0e+00 |
|
excinuclease ABC subunit UvrC;
Pssm-ID: 234792 [Multi-domain] Cd Length: 598 Bit Score: 924.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 55 ELIGEFVKRLPNSPGVYRMFNAEGDVLYVGKARSLKKRVNNYAVGRVHSNRIAQMVRQTANMEFVTTRTETEALLLEANL 134
Cdd:PRK00558 2 EFLKEKLKTLPDSPGVYRMKDANGTVIYVGKAKNLKNRVRSYFRKSHDSPKTRAMVSEIADIEYIVTRSETEALLLENNL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 135 IKRLRPRFNVLLRDDKSFPYILITGDHRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTDSVFETRT 214
Cdd:PRK00558 82 IKKYKPRYNVLLRDDKSYPYIKITTNEEFPRLAITRGVAKDKGRYFGPYPSAGAVRETLDLLQKLFPLRTCEDSVFKNRK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 215 RPCLLYQIKRCSGPCTHEVSDGGYGELVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSHQG 294
Cdd:PRK00558 162 RPCLLYQIGRCLAPCVGLISKEEYAELVDEAKLFLSGKTDEVLKELEEKMEEASENLEFERAARYRDQIQALRRVQEKQK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 295 INPAGVEEADVFAIHHEGGISCIQVFFFRTGQNWGNRAYFPKADPQlSSAEVLNSFLAQFYDDKPVPKQIMLSQTVEELE 374
Cdd:PRK00558 242 VSLKDGEDADVIAIAVDGGWACVQVFFVRGGKLLGRRSYFPKVSET-ELEEILEAFLGQFYLQKSIPKEILVPHELDDEE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 375 LLAAAlseKAGHKVSMLVPQRGEKRDLVDHVVGNAREAHGRKLAETASQSRLLEGFKETFGLAYAPQRIEIYDNSHIMGT 454
Cdd:PRK00558 321 LAEAL---LAGRKVKIRVPQRGDKKELLELAEKNAREALERKLSDQSTQQQALEELAELLGLPEPPYRIECFDISHIQGT 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 455 NAVGGMVVAGPEGFVKNQYRKFNIKStdITPGDDFGMMKEVMTRRFSRLIKEEGIpdrtaqvatpdaadmpfptWPDVIL 534
Cdd:PRK00558 398 ATVASMVVFEDGGPDKSEYRRYNIKG--VTGGDDYAAMREVLTRRYSRLLKEFGP-------------------LPDLIL 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 535 IDGGQGQMTAVRAILAELGITdsVTAIGIAKGVDRDAGRER-FFPPGRESFTLPPRDPVLYFIQRMRDEAHRFAIGSHRA 613
Cdd:PRK00558 457 IDGGKGQLNAAKEVLEELGLD--IPVVGLAKGDKRKAGTEElFFPGEPEPIILPPDSPALYLLQRIRDEAHRFAITFHRK 534
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115256001 614 RRKKEMIKNPLDEIGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVEGISEAVARQVYNHFHDD 677
Cdd:PRK00558 535 KRSKARLTSALDDIPGIGPKRRKALLKHFGSLKAIKEASVEELAKVPGISKKLAEAIYEALHKK 598
|
|
| UvrC |
COG0322 |
Excinuclease UvrABC, nuclease subunit [Replication, recombination and repair]; |
53-677 |
0e+00 |
|
Excinuclease UvrABC, nuclease subunit [Replication, recombination and repair];
Pssm-ID: 440091 [Multi-domain] Cd Length: 603 Bit Score: 901.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 53 GAELIGEFVKRLPNSPGVYRMFNAEGDVLYVGKARSLKKRVNNYAVGRVHSNRIAQMVRQTANMEFVTTRTETEALLLEA 132
Cdd:COG0322 2 DPFDLKEKLKTLPTSPGVYLMKDANGEVIYVGKAKNLKNRVSSYFQKSDLSPKTRRMVSEIADIEYIVTDTETEALLLEN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 133 NLIKRLRPRFNVLLRDDKSFPYILITgDHRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTDSVFET 212
Cdd:COG0322 82 NLIKKHKPRYNILLKDDKSYPYIKIT-NEEFPRIFVTRGVKKDGGRYFGPYPSAGAVRETLDLLQKLFPLRTCSDSLFKN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 213 RTRPCLLYQIKRCSGPCTHEVSDGGYGELVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSH 292
Cdd:COG0322 161 RSRPCLLYQIGRCSAPCVGLISEEEYREDVEQARRFLEGKTKELIKELEEKMEEAAEELEFERAARLRDQIRALEKVQEK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 293 QGINPAGVEEADVFAIHHEGGISCIQVFFFRTGQNWGNRAYFPKADPQLSSAEVLNSFLAQFYDDKP-VPKQIMLSQTVE 371
Cdd:COG0322 241 QKVVLPDGGDADVIAIARDGGEACVQVFFVRGGRLIGRRSFFLEKVLDEDDEELLEAFLAQYYLDRPsIPKEILVPEELE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 372 ELELLAAALSEKAGHKVSMLVPQRGEKRDLVDHVVGNAREAHGRKLAET----ASQSRLLEGFKETFGLAYAPQRIEIYD 447
Cdd:COG0322 321 DAELLEEWLSERRGRKVKIRVPQRGEKKKLLELAEKNAREALERKLAERerdeARQERALEELAEALGLPELPRRIECFD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 448 NSHIMGTNAVGGMVVAGPEGFVKNQYRKFNIKStdITPGDDFGMMKEVMTRRFSRLIKEEGipdrtaqvatpdaadmpfp 527
Cdd:COG0322 401 ISHIQGTNTVASMVVFEDGKPDKSDYRRFKIKT--VEGGDDYASMREVLTRRYKRLLEEDE------------------- 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 528 TWPDVILIDGGQGQMTAVRAILAELGITDsVTAIGIAKgvdRDagRERFFPPGRESFTLPPRDPVLYFIQRMRDEAHRFA 607
Cdd:COG0322 460 PLPDLILIDGGKGQLNAAREVLEELGLDD-IPVIGLAK---RD--EELFLPGDSEPIILPRNSPALYLLQRIRDEAHRFA 533
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 608 IGSHRARRKKEMIKNPLDEIGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVEGISEAVARQVYNHFHDD 677
Cdd:COG0322 534 ITFHRKLRSKARLKSVLDEIPGIGPKRRKALLKHFGSLKAIKEASVEELAAVPGISKKLAEAIYEYLHKE 603
|
|
| uvrC |
TIGR00194 |
excinuclease ABC, C subunit; This family consists of the DNA repair enzyme UvrC, an ABC ... |
59-655 |
0e+00 |
|
excinuclease ABC, C subunit; This family consists of the DNA repair enzyme UvrC, an ABC excinuclease subunit which interacts with the UvrA/UvrB complex to excise UV-damaged nucleotide segments. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 272953 [Multi-domain] Cd Length: 574 Bit Score: 556.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 59 EFVKRLPNSPGVYRMFNAEGDVLYVGKARSLKKRVNNYAVGRvHSNRIAQMVRQTANMEFVTTRTETEALLLEANLIKRL 138
Cdd:TIGR00194 3 EKLKNLPDKPGCYLMKDRNGQVLYVGKAKNLKKRVSSYFREN-NSAKTQALVKQIADIEYILTKNENEALILEANLIKQY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 139 RPRFNVLLRDDKSFPYILITGDhRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTDSvfeTRTRPCL 218
Cdd:TIGR00194 82 QPRYNVLLKDDKGYPYIYITHE-KYPRLLITRKLKQDKGKYFGPFTNAFALRETLDLLLKLFPLRKCAKH---NRNRPCL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 219 LYQIKRCSGPCTHEVSDGGYGELVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSHQGINPA 298
Cdd:TIGR00194 158 YYQIGRCLGPCVKEITEEEYQQIVEKIELFFNGRPQEVIKELEQKMEKASENLEFEEAARIRDQIAAVRELNEKQHVSLT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 299 GVEEADVFAIHHEGGISCIQVFFFRTGQNWGNRAYFPKAdPQLSSAEVLNSFLAQFY----DDKPVPKQIMLSQTVEELE 374
Cdd:TIGR00194 238 DLIDLDIIAVAFDGNVAAIQVFFIRQGKLIGRDQFDFSL-PGTDLDELVETFLIQFYqqgyQNRLIPSEILVSLSLEDLK 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 375 LLAAALSEKAGHKVSMLVPQRGEKRDLVDHVVGNAREAHGRKLAETASQSRLLEGFKETFGLaYAPQRIEIYDNSHIMGT 454
Cdd:TIGR00194 317 LLEDLLSEQRGRKINVHQPKKGDKKKLLELAIKNAKYALKQKWTQFERKTQALEDLASLLNL-PKIKRIEIFDISHIDGS 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 455 NAVGGMVVAGPEGFVKNQYRKFNIKStdITPGDDFGMMKEVMTRRFSRLIKEEGIPdrtaqvatpdaadmpfptWPDVIL 534
Cdd:TIGR00194 396 QTVGSMVVFEDGKPLKASYRRYNINS--ITGGDDYAAMREVLRRRYSSIQKKNNLP------------------LPDLIL 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 535 IDGGQGQMTAVRAILAELGITDSVTAIGIAKgVDRDAGRErFFPPGRESFTLPPRDPVLYFIQRMRDEAHRFAIGSHRAR 614
Cdd:TIGR00194 456 IDGGKGQLNAALEVLKSLGVVNKPIVIGLAK-AKRHETDI-FLIGDKQGINIDLNSPALQLLQHIRDEAHRFAISFHRKK 533
|
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 115256001 615 RKKEMIKNPLDEIGGIGPSRKRALLQHFGTAKAVSRAALSD 655
Cdd:TIGR00194 534 RLKASLQSPLLKIPGVGEKRVQKLLKYFGSLKGIKKASVEE 574
|
|
| uvrC |
PRK14669 |
excinuclease ABC subunit C; Provisional |
61-679 |
1.67e-137 |
|
excinuclease ABC subunit C; Provisional
Pssm-ID: 237784 [Multi-domain] Cd Length: 624 Bit Score: 417.00 E-value: 1.67e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 61 VKRLPNSPGVYRMFNAEGDVLYVGKARSLKKRVNNYAV-GRVHSNRIAQMVRQTANMEFVTTRTETEALLLEANLIKRLR 139
Cdd:PRK14669 7 IRTLPTSPGVYLYKNAGGEVIYVGKAKNLRSRVRSYFSeDKLGNIKTGSLIREAVDIDYILVDNEKEALALENNLIKQYK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 140 PRFNVLLRDDKSFPYILITGDHRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTDSVFETRTRPCLL 219
Cdd:PRK14669 87 PRFNILLRDDKTYPYVKLTLGEKYPRVYVTRRLRKDGAQYYGPFFPANLAYRLVDLIHRHFLVPSCKVDLTRYHPRPCLQ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 220 YQIKRCSGPCT-HEVSDGGYGELVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSHQGINPA 298
Cdd:PRK14669 167 FYIHRCLGPCVqGLTTDEAYAEAVRDVRLFLEGRHSDLARSLRARMEAAALEMQFELAAKYRDLITTVEELEEKQRMAAA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 299 GVEEADVFAIHHEGGISCIQVFFFRTGQNWGNRAYF------PKADPQLSSAEVLNSFLAQFYDDKP-VPKQIMLSQTVE 371
Cdd:PRK14669 247 KGDDADVFGYHYENPMVAVNLFHMRGGKIVDRREFFwedlgeVQVEFEYDEGLFFSSLLKQIYLDQQyVPREIYVPVEFE 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 372 ELELLAAALSEKAGHKVSMLVPQRGEKRDLVDHVVGNAREAHGRKLAETASQSRLL-EGFKETFGLAYAPQRIEIYDNSH 450
Cdd:PRK14669 327 DREALEELLTEQRHRRIEIRVPQRGDKRSLLDLVEQNAKQSYDQRFRVMKPSSRAIqEALQDALNLPELPSRIECFDISH 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 451 IMGTNAVGGMVVAGPEGFVKNQYRKFNIKStdITPGDDFGMMKEVMTRRFSRLIKEEgipdrtaqvatpdaadmpfPTWP 530
Cdd:PRK14669 407 IQGAETVASMVVWEDGKMKKSDYRKFIIKT--VVGVDDFASMREVVTRRYSRLQEEK-------------------QPMP 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 531 DVILIDGGQGQMTAVRAILAELGITDSVTAiGIAKgvdRDagrERFFPPGRES--FTLPPRDPVLYFIQRMRDEAHRFAI 608
Cdd:PRK14669 466 GLVLIDGGLGQLHAAAEALEAIGITDQPLA-SIAK---RE---EIIYVFGQEDepIVLDRFSPVLHLVQSIRDEAHRFAI 538
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115256001 609 GSHRARRKKEMIKNPLDEIGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVegISEAVARQVYNHFHDDAA 679
Cdd:PRK14669 539 TFHRKRRETRDRTSELLEIPGVGAKTVQRLLKHFGSLERVRAATETQLAAV--VGRAAAEAIIAHFTTEEA 607
|
|
| uvrC |
PRK14666 |
excinuclease ABC subunit C; Provisional |
64-673 |
8.50e-110 |
|
excinuclease ABC subunit C; Provisional
Pssm-ID: 237782 [Multi-domain] Cd Length: 694 Bit Score: 347.26 E-value: 8.50e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 64 LPNSPGVYRMFNAEGDVLYVGKARSLKKRVNNY--AVGRvHSNRIAQMVRQTANMEFVTTRTETEALLLEANLIKRLRPR 141
Cdd:PRK14666 9 IPLTPGVYLYKDEAGRIIYVGKARHLRRRVASYfrDVSA-LTPKTVAMLRHAVTIDTLSTTTEKEALLLEASLIKKHRPR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 142 FNVLLRDDKSFPYILITGDHRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTDSVFETRTRPCLLYQ 221
Cdd:PRK14666 88 YNIVLRDDKQYVLFRLGAKHPYPRLEIVRKARRDGARYFGPFTSASAARETWKTIHRAFPLRRCSDRAFGNRVRACLYHF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 222 IKRCSGPCTHEVSDGGYGELVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSHQGINPAGVE 301
Cdd:PRK14666 168 MGQCLGPCVNDVPRETYAALVRKVEMLLSGRSGELVDALRTEMEAASEALEFERAAVLRDQIRAVERTVERQAAVLPGGG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 302 EADVFAIHHEGGISCIQVFFFRTGQNWGNRAYFPKADPQLSSAEVLNSFLAQFY-------------------------- 355
Cdd:PRK14666 248 DLDVVGLVEAEGGLALGVLFVRQGVLLDGRAFFWPGLGFEEAPELLWSFLGQFYgpqstipprivvpwlpdtegregddl 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 356 ---------------------------------------------------------------DDKPVPKQIMLSQT--V 370
Cdd:PRK14666 328 aptavctdagllpdtpllpdapegssdpvvpvaaatpvdaslpdvrtgtaptslanvshadpaVAQPTQAATLAGAApkG 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 371 EELELLAAALSEKAGHKVSMLVPQRGEKRDLVDHVVGNAREaHGRKLAETASQSRLlegfKETFGLAYAPQRIEIYDNSH 450
Cdd:PRK14666 408 ATHLMLEETLADLRGGPVRIVPPRNPAENRLVDMAMSNARE-EARRKAETPLQDLL----ARALHLSGPPHRIEAVDVSH 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 451 IMGTNAVGGMVVAGPEGFVKNQYRKFNIKSTDitpGDDFGMMKEVMTRRFsrlikEEGipdrtaqvatpdaadmpfPTWP 530
Cdd:PRK14666 483 TGGRNTRVGMVVFEDGKPARDAYRTYAFEDGE---GDDYGTLAAWAGRRV-----ESG------------------PPWP 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 531 DVILIDGGQGQMTAVRAILAELGITDSVTAIGIAKG------VDRDAGR--ERFFPPGReSFTLPPRD--PVLYFIQRMR 600
Cdd:PRK14666 537 DLLLVDGGRGQLAAVVRALEEAGMGGLFAVASIAKArteegrADRRAGNvaDRIFLPGR-ANPLPLRAgaPELLFLQHVR 615
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115256001 601 DEAHRFAIGSHRARRKKEMIKNPLDEIGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVEGISEAVARQVYNH 673
Cdd:PRK14666 616 DTVHDYAIGRHRRARAGAALTGELQRVEGIGPATARLLWERFGSLQAMAAAGEEGLAAVPGIGPARAAALHEH 688
|
|
| uvrC |
PRK14668 |
excinuclease ABC subunit C; Provisional |
64-670 |
1.65e-107 |
|
excinuclease ABC subunit C; Provisional
Pssm-ID: 184785 [Multi-domain] Cd Length: 577 Bit Score: 337.51 E-value: 1.65e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 64 LPNSPGVYRmFNAEGDVLYVGKARSLKKRVNNYAVGRvhSNRIAQMVRQTANMEFVTTRTETEALLLEANLIKRLRPRFN 143
Cdd:PRK14668 13 LPREPGVYQ-FVAGGTVLYVGKAVDLRDRVRSYADPR--SERIRRMVERADDIDFAVTDTETQALLLEANLIKRHQPRYN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 144 VLLRDDKSFPYILITgDHRAPAIFKHRGARArKGDYFGPFASAGAVGRTINSLQRAFLIRTCTDSVFETRTRPCLLYQIK 223
Cdd:PRK14668 90 VRLKDDKSYPLVQLT-DHPVPRIEVTRDPDE-GATVFGPYTDKGRVETVVKALRETYGLRGCSDHKYSNRDRPCLDYEMG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 224 RCSGPCTHEVSDGGYGELVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALS--HVQSHQGINPAGVE 301
Cdd:PRK14668 168 LCTAPCTGEIDEEAYAEDVESAERFFEGETGVLADPLRREMEAAAQAQEFERAANLRDRLEAVEafHGGGGEAVSSTGDE 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 302 EA-DVFAIHHEGGISCIQVFFFRTGQNWG-NRAYFPKADPQLSSAEVLNSFLAQFYDDKPVPKQIMLSQTVEELELLAAA 379
Cdd:PRK14668 248 RAvDVLGVAIEGDRATVARLHAEGGQLVDrDRHRLEAPDGEDRGAAVLAAFIVQYYAERELPDALLLSERPGDDDVRAWL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 380 LSEkaghKVSMLVPQRGEKRDLVDHVVGNAREAHGRKLAETASQSRLleGFKetfglayAPQRIEIYDNSHIMGTNAVGG 459
Cdd:PRK14668 328 EAE----GVDVRVPGAGREATLVDLALKNARRRGGRDDEVGALADAL--GID-------RPERIEGFDVSHAQGRAVVGS 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 460 MVVAGPEGFVKNQYRKFNIKSTDitpgDDFGMMKEVMTRRFSRLIkeEGIPDRtaqvatPDaadmpfptwPDVILIDGGQ 539
Cdd:PRK14668 395 NVCFVDGSAETADYRRKKLTERN----DDYANMRELVRWRAERAV--EGRDDR------PD---------PDLLLIDGGD 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 540 GQMTAVRAILAELGItdSVTAIGIAKgvdrdaGRERFFPPGReSFTLPPRDPVLYFIQRMRDEAHRFAIGSHRARRKKem 619
Cdd:PRK14668 454 GQLGAARDALAETGW--DVPAIALAK------AEELVVTPDR-TYDWPDDAPQLHLLQRVRDEAHRFAVQYHQTLRDD-- 522
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|.
gi 115256001 620 IKNPLDEIGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVEGISEAVARQV 670
Cdd:PRK14668 523 VSTVLDDVPGVGPETRKRLLRRFGSVEGVREASVEDLRDVPGVGEKTAETI 573
|
|
| uvrC |
PRK14667 |
excinuclease ABC subunit C; Provisional |
55-670 |
4.02e-89 |
|
excinuclease ABC subunit C; Provisional
Pssm-ID: 237783 [Multi-domain] Cd Length: 567 Bit Score: 288.94 E-value: 4.02e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 55 ELIGEFVKRLPNSPGVYrMFNAEGDVLYVGKARSLKKRVNNYAVGRVHSNRIAQMVRQTANMEFVTTRTETEALLLEANL 134
Cdd:PRK14667 4 MDALELIEKAPEEPGVY-LFKKKKRYIYIGKAKNIKNRLLQHYKQSETDPKERAIFSESSSLEWIITRNEYEALVLEIDL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 135 IKRLRPRFNVLLRDDKSFPYILITGDhRAPAIFKHRGArARKGDYFGPFASAG---AVGRTINSLqraFLIRTCTDsvFE 211
Cdd:PRK14667 83 IQQYKPKYNVLLKSGSGYPMLLITDD-EYPTVKIVRGT-GEKGEYFGPFLPARkarKVKKLIHKL---FKLRTCDP--MP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 212 TRTRPCLLYQIKRCSGPCTHEVSDGGYGELVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQS 291
Cdd:PRK14667 156 KRKEPCMDYHLGLCSGPCCGKISKEDYELSVKSAKAFLSGNVKEVLPELYDKIEEYSQKLMFEKAAVIRDQILALENLIK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 292 HQGINPAGVEEADVFaiHHEGgiSCIQVFFFRtgqnwGNRaYFPKADPQLSSAEVLN-SFLAQFYDDKPVPKQIMLSQTV 370
Cdd:PRK14667 236 GQEVSGLPIEEADIF--YFMG--SRLGLFLVR-----SSK-LVGKEEFRLESEEQEEeEVILGYYYSNYIPQKIITNFEL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 371 eeLELLAAALSEKAGHKVSMLVPQRGEKRDLVDhvvgnareahgRKLAETASQSRLLEGFKETFGLAyAPQRIEIYDNSH 450
Cdd:PRK14667 306 --SDNLKQWLSKRKGGDVEFLTLIPKELEKFIE-----------ENIGIKVDLEVLKEEFKKTFGFP-LPERIEGFDISH 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 451 IMGTNAVGGMVVAGPEGFVKNQYRKFNIKSTDITpgDDFGMMKEVMTRRFSRLIKEEGipdrtaqvatpdaadmpfpTWP 530
Cdd:PRK14667 372 FYGEFTVGSCVVWEDGSMNKKEYRRYKIKTVDGI--DDYASLREVLTRRARRYKEGEN-------------------PMP 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 531 DVILIDGGQGQMTAVRAILAELGITDSVTAigIAKGVD---RDAGRErffPPGRESftlpprdPVLY-FIQRMRDEAHRF 606
Cdd:PRK14667 431 DLWLIDGGKGQLSVGIEVRDRLGLNIKVFS--LAKKEEilyTEDGKE---IPLKEN-------PILYkVFGLIRDEAHRF 498
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115256001 607 AIGSHRARRKKEMIKNPLDEIGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVeGISEAVARQV 670
Cdd:PRK14667 499 ALSYNRKLREKEGLKDILDKIKGIGEVKKEIIYRNFKTLYDFLKADDEELKKL-GIPPSVKQEV 561
|
|
| uvrC |
PRK14670 |
excinuclease ABC subunit C; Provisional |
73-648 |
2.40e-74 |
|
excinuclease ABC subunit C; Provisional
Pssm-ID: 173133 [Multi-domain] Cd Length: 574 Bit Score: 250.21 E-value: 2.40e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 73 MFNAEGDVLYVGKARSLKKRVNNYAVGRVhSNRIAQMVRQTANMEFVTTRTETEALLLEANLIKRLRPRFNVLLRDDKSF 152
Cdd:PRK14670 1 MYSENNKILYIGKAKNLRSRVKNYFLEKI-SHKTKILMKNVKNIEVITTNSEYEALLLECNLIKTHKPDYNIKLKDDKGY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 153 PYILITGDhRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTdsvfETRTRPCLLYQIKRCSGPCTHE 232
Cdd:PRK14670 80 PMIRITCE-KYPRIFKTRKIINDGSEYFGPYVNVKKLDLVLDLINKTFKTRKCK----KKSKNPCLYFHMGQCLGVCYRE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 233 VSDGGYGELVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSHQGINPAGVEEADVFAIHHEG 312
Cdd:PRK14670 155 DLEKEYQKEVDKIKHILNGNISKLLSQIEIKMKEAIQKEDFEAAIKLKETKRSLIEISQTQIITKINKLSIDYVYIHPTE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 313 GISCIQVFFFRTGQNWGNRAYFPKAdpQLSSAEVLNSFLAQFYD--DKPVPKQIMLSQTVeELELLAAALSEKAGHKVSM 390
Cdd:PRK14670 235 NLNTIVILKYKDGKLVEKDINFDES--IYEEDELILQFITQYYTsiNMIVPDKIHIFKKI-DTKNITKLINELKNTKTEI 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 391 LVPQRGEKRDLVDHVVGNAREAhgrKLAETASQSRLLEGFKETFGLAYAPQRIEIYDNSHIMGTNAVGGMVVAGPEGFVK 470
Cdd:PRK14670 312 IYKETKEIIKIMEMAISNAKLA---LREYENEKNKALESLKIILEMDKLPKTIEGFDIAHLNGQKTVASLVTFKMGKPFK 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 471 NQYRKFNIKSTDITPGDDFGMMKEVMTRRFSRLIKEegipdrtaQVATpdaadmpfptwPDVILIDGGQGQMTAVRAILA 550
Cdd:PRK14670 389 DGYRVYKINSLLKGEIDDFKAIKEVISRRYSKLINE--------QLEL-----------PNLILIDGGKGQLNAAYSILK 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 551 ELGITDSVTAIGIAKgvdrdagRER--FFPPGRESFTLPPRDPVLYFIQRMRDEAHRFAIGSHRARRKKemIKNPLDEIG 628
Cdd:PRK14670 450 GLKIENKVKVCALAK-------KEEtiFLPNKKQGIKLPKGNPALRILQNVRDEAHRKANGFNKKLREN--IKLNYTKIK 520
|
570 580
....*....|....*....|
gi 115256001 629 GIGPSRKRALLQHFGTAKAV 648
Cdd:PRK14670 521 GIGEKKAKKILKSLGTYKDI 540
|
|
| UvrC_RNaseH_dom |
pfam08459 |
UvrC RNAse H endonuclease domain; This domain is found in the C subunits of the bacterial and ... |
431-607 |
1.76e-67 |
|
UvrC RNAse H endonuclease domain; This domain is found in the C subunits of the bacterial and archaeal UvrABC system which catalyzes nucleotide excision repair in a multi-step process. UvrC catalyzes the first incision on the fourth or fifth phosphodiester bond 3' and on the eighth phosphodiester bond 5' from the damage that is to be excised. The domain described here represents the RNAse H endonuclease domain, located at the C-terminal, between the UvrBC and the (HhH)2 domains, nearby the N-terminal of the HhH. Despite the lack of sequence homology, the endonuclease domain has an RNase H-like fold, which is characteriztic of enzymes with nuclease or polynucleotide transferase activities. RNase H-related enzymes typically contain a highly conserved carboxylate triad, usually DDE, in their catalytic centre. However, instead of a third carboxylate, UvrC of Thermotoga maritima was found to contain a highly conserved histidine (H488) on helix-4 in close proximity to two aspartates.
Pssm-ID: 462484 [Multi-domain] Cd Length: 150 Bit Score: 217.70 E-value: 1.76e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 431 KETFGLAYAPQRIEIYDNSHIMGTNAVGGMVVAGPEGFVKNQYRKFNIKSTdiTPGDDFGMMKEVMTRRFSRLIKEEGIp 510
Cdd:pfam08459 1 QEALGLPKLPRRIECFDISHIQGTDTVASMVVFEDGKPDKSDYRRFNIKTT--VGPDDYASMREVLTRRFSRLLEEFGP- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 511 drtaqvatpdaadmpfptWPDVILIDGGQGQMTAVRAILAELGItdSVTAIGIAKGVDRDAGRERffppGRESFTLPPRD 590
Cdd:pfam08459 78 ------------------LPDLILIDGGKGQLNAALEVLEELGL--DIPVIGLAKDDKHKIDTDG----REEEIILPRDS 133
|
170
....*....|....*..
gi 115256001 591 PVLYFIQRMRDEAHRFA 607
Cdd:pfam08459 134 PALHLLQRIRDEAHRFA 150
|
|
| uvrC |
PRK14672 |
excinuclease ABC subunit C; Provisional |
65-656 |
3.01e-65 |
|
excinuclease ABC subunit C; Provisional
Pssm-ID: 173135 [Multi-domain] Cd Length: 691 Bit Score: 228.46 E-value: 3.01e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 65 PNSPGVYRMFNAEGDVLYVGKARSLKKRVNNYAVGRvHSNRIAQMVRQTANMEFVTTRTETEALLLEANLIKRLRPRFNV 144
Cdd:PRK14672 19 PSTSGVYLWKDVHGVVIYVGKAKSLRTRLTSYFRCR-HDPKTRVLMSRAAALEYLQTQHEYEALLLENTLIKKHTPRYNI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 145 LLRDDKSFPYILITGDhRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTdsVFETRTRPCLLYQIKR 224
Cdd:PRK14672 98 CLKDGKTYPLLKLTCE-PFPRIFRTRQFCQDGARYFGPFPDVQILDSFLKLILRTYKIRTCT--TLRKRKNPCLYYHLKR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 225 CSGPCTHEVSDGGYGELVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSHQGINPAGVEEAD 304
Cdd:PRK14672 175 CDAPCCGWVSPRTYQKDIHEITLLLEGNIDATVARLEKRMKRAVRQEAFEAAARIRDDIQAIRCITHKSLVQDMDERARD 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 305 VFAIHHEGGISCIQVFFFRTGQNWGNRAYfpKADPQLSSAEVLNSFLAQFYDDKPVPKQIMLSQTVeelELLAAALSEKA 384
Cdd:PRK14672 255 YIAWSSTGAIVTFAVLRMRGGKLNGRELF--RTRSLKNEEEILSEFLITYYSDHTIPPHLFVHSSA---GLAEHWLSHKA 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 385 GHKVSMLV--------PQRGEKR------DLVDHVVGNAREAHG-RKLAETASQSRL----------------------- 426
Cdd:PRK14672 330 GTQCTVTLiplhtfptPQTPSSTvttnapTLAASQNSNAVQDSGlRSCSETSTMHTLqkahdactasegtrentphesah 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 427 -------------------------------LEGFKETFGLAYAPQRIEIYDNSHIMGTNAVGGMVVAGPEGFVKNQYRK 475
Cdd:PRK14672 410 tphhrailamaqlnaheditrylknrgaddaLKELQKQLHLARIPTLIEGFDISHLGGKYTVASLICFKNGAPDTKNYRL 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 476 FNIKSTDiTPGDDFGMMKEVMTRRFSRlikeegipdrtaqvaTPDAAdmpfpTWPDVILIDGGQGQMTAVRAILAELGIt 555
Cdd:PRK14672 490 FNLRAHD-TRIDDFASMREAIARRYTH---------------TPEGY-----TLPDLILVDGGIGHVSAAQHVLDALGL- 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 556 dSVTAIGIAKGVDrdagrERFFPPGRESFTLPPRDPVLYFIQRMRDEAHRFAIGSHRARRKKEMIKNPLDEIGGIGPSRK 635
Cdd:PRK14672 548 -SIPLVGLAKRAE-----ELFIPNSPTPLVLDRRNPALHMLQRIRDEAHRFAITRNRHLRTKKELVLSFERLPHVGKVRA 621
|
650 660
....*....|....*....|.
gi 115256001 636 RALLQHFGTAKAVSRAALSDL 656
Cdd:PRK14672 622 HRLLAHFGSFRSLQSATPQDI 642
|
|
| PRK07883 |
PRK07883 |
DEDD exonuclease domain-containing protein; |
63-286 |
5.16e-49 |
|
DEDD exonuclease domain-containing protein;
Pssm-ID: 236123 [Multi-domain] Cd Length: 557 Bit Score: 180.50 E-value: 5.16e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 63 RLPNSPGVYRMFNAEGDVLYVGKARSLKKRVNNYAVGRVHSNRIAQMVRQTANMEFVTTRTETEALLLEANLIKRLRPRF 142
Cdd:PRK07883 213 GLPHAPGVYLFRGPSGEVLYVGTAVNLRRRVRSYFTAAETRGRMREMVALAERVDHVECAHALEAEVRELRLIAAHKPPY 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 143 NVLLRDDKSFPYILITgDHRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTD--SVFETRTRPCLLY 220
Cdd:PRK07883 293 NRRSKFPERRWWVRLT-DEAFPRLSVVRAVEDDGAAYLGPFRSRRAAEEAAEALARAFPLRQCTDrlSRRARHGPACALA 371
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115256001 221 QIKRCSGPCTHEVSDGGYGELVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAAL 286
Cdd:PRK07883 372 ELGRCPAPCDGRESAAEYAEAVARARAALTGDDDAVLAALRARIDRLAAAERFEEAARLRDRLAAL 437
|
|
| GIY-YIG_UvrC_Cho |
cd10434 |
Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar ... |
64-144 |
1.08e-39 |
|
Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; UvrC is essential for nucleotide excision repair (NER). The N-terminal catalytic GIY-YIG domain of UvrC (also known as Uri domain) is responsible for the 3' incision reaction and the C-terminal half of UvrC, consisting of an UvrB-binding domain (UvrBb), EndoV-like nuclease domain and a helix-hairpin-helix (HhH) DNA-binding domain, contains the residues involved in 5' incision. The N- and C-terminal regions are joined by a common Cys-rich domain containing four conserved Cys residues. Besides UvrC, protein Cho (UvrC homolog) serves as a second endonuclease in E. coli NER. Cho contains GIY-YIG motif followed by a Cys-rich region and shares sequence homology with the N-terminal half of UvrC. It is capable of incising the DNA at the 3' side of a lesion in the presence of the UvrA and UvrB proteins during NER. The C-terminal half of Cho is a unique uncharacterized domain, which is distinct from that of UvrC. Moreover, unlike UvrC, Cho does not require the UvrC-binding domain of UvrB for the 3' incision reaction, which might cause the shift in incision position and the difference in incision efficiencies between Cho and UvrC on different damaged substrates. Due to this, the range of NER in E. coli can be broadened by combining action of Cho and UvrC. This family also includes many uncharacterized epsilon proofreading subunits of DNA polymerase III, which have an additional N-terminal ExoIII domain and a 3'-5' exonuclease domain homolog, fused to an UvrC-like region or a Cho-like region. The UvrC-like region includes a GIY-YIG motif, followed by a Cys-rich region, and an UvrB-binding domain (UvrBb), but lacks the EndoV-like nuclease domain and the helix-hairpin-helix (HhH) DNA-binding domain. The Cho-like region consists of a GIY-YIG motif, followed by the Cys-rich region, and the unique uncharacterized domain presenting in the C-terminal half of Cho. Some family members may not carry the Cys-rich region. This family also includes a specific Cho-like protein from G. violaceus, which possesses only UvrBb domain at the C-terminus, but lacks the additional N-terminal ExoIII domain. The oother two remote homologs of UvrC, Bacillus-I and -II, are included in this family as well. Both of them contain a GIY-YIG domain, but no Cys-rich region. Moreover, the whole C-terminal region of Bacillus-I is replaces by an unknown domain, and Bacillus-II possesses another unknown N-terminal extension.
Pssm-ID: 198381 [Multi-domain] Cd Length: 81 Bit Score: 140.31 E-value: 1.08e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 64 LPNSPGVYRMFNAEGDVLYVGKARSLKKRVNNYAVGRVHSNRIAQMVRQTANMEFVTTRTETEALLLEANLIKRLRPRFN 143
Cdd:cd10434 1 LPDSPGVYLFKDADGEVLYVGKAKNLRKRVSSYFTGERHSPKTRRLVEEIRDIEYIVTDSELEALLLEANLIKKYKPRYN 80
|
.
gi 115256001 144 V 144
Cdd:cd10434 81 I 81
|
|
| PRK10545 |
PRK10545 |
excinuclease Cho; |
59-229 |
2.42e-17 |
|
excinuclease Cho;
Pssm-ID: 182535 Cd Length: 286 Bit Score: 82.80 E-value: 2.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 59 EFVKRLPNSPGVYrMFNAEGDV--LYVGKARSLKKRVnnyaVGRVHSNRIAQMVRQTANMEFVTTRTETEALLLEANLIK 136
Cdd:PRK10545 26 PFLEDLPKLPGVY-LFHGESDTmpLYIGKSVNIRSRV----LSHLRTPDEAAMLRQSRRISWICTAGEIGALLLEARLIK 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 137 RLRPRFNVLLRDDKSFPYILITGD-----HRAPAIFkhrgarARKGDYFGPFASAGAVGRTINSLqrAFLIRTCTDSV-F 210
Cdd:PRK10545 101 EQQPLFNKRLRRNRQLCSLQLNEGrvdvvYAKEVDF------SRAPNLFGLFANRRAALQALQSI--ADEQKLCYGLLgL 172
|
170 180
....*....|....*....|.
gi 115256001 211 E--TRTRPCLLYQIKRCSGPC 229
Cdd:PRK10545 173 EplSRGRACFRSALKRCAGAC 193
|
|
| GIYc |
smart00465 |
GIY-YIG type nucleases (URI domain); |
68-148 |
5.59e-14 |
|
GIY-YIG type nucleases (URI domain);
Pssm-ID: 214677 [Multi-domain] Cd Length: 84 Bit Score: 67.45 E-value: 5.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115256001 68 PGVYRMFNAEGDVLYVGKARSLKKRVNNYAVGRVHSNRIAQMV-RQTANMEFVTTRTETE-ALLLEANLIKRLRPRFNVL 145
Cdd:smart00465 2 PGVYYITNKKNGKLYVGKAKNLRNRLKRHFSGSRKGRLLIDALlKYGGNFEFIILESFDEsALELEKYLIKEYKPKYNLL 81
|
...
gi 115256001 146 LRD 148
Cdd:smart00465 82 LKG 84
|
|
| GIY-YIG |
pfam01541 |
GIY-YIG catalytic domain; This domain called GIY-YIG is found in the amino terminal region of ... |
68-141 |
2.18e-09 |
|
GIY-YIG catalytic domain; This domain called GIY-YIG is found in the amino terminal region of excinuclease abc subunit c (uvrC), bacteriophage T4 endonucleases segA, segB, segC, segD and segE; it is also found in putative endonucleases encoded by group I introns of fungi and phage. The structure of I-TevI a GIY-YIG endonuclease, reveals a novel alpha/beta-fold with a central three-stranded antiparallel beta-sheet flanked by three helices. The most conserved and putative catalytic residues are located on a shallow, concave surface and include a metal coordination site.
Pssm-ID: 426314 [Multi-domain] Cd Length: 78 Bit Score: 54.27 E-value: 2.18e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115256001 68 PGVYRMFNAEGDVLYVGKARSLKKRVNNYAVGRVHSNRIAQMVRQTAnMEFVT-TRTETEALLLEANLIKRLRPR 141
Cdd:pfam01541 2 GGIYIIRNKDNKLLYVGSTKNLERRLNQHNAGKGAKYTRGKGVEPFK-LIYLEeFPTKSEALELEKYLIKLYRPN 75
|
|
| MUS81 |
COG1948 |
ERCC4-type crossover junction endonuclease [Replication, recombination and repair]; |
627-671 |
5.72e-09 |
|
ERCC4-type crossover junction endonuclease [Replication, recombination and repair];
Pssm-ID: 441551 [Multi-domain] Cd Length: 214 Bit Score: 56.72 E-value: 5.72e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 115256001 627 IGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVEGISEAVARQVY 671
Cdd:COG1948 160 LPGIGPKLARRLLEHFGSVEAVFNASEEELMKVEGIGEKTAERIR 204
|
|
| UVR |
pfam02151 |
UvrB/uvrC motif; |
254-287 |
7.83e-08 |
|
UvrB/uvrC motif;
Pssm-ID: 308001 [Multi-domain] Cd Length: 36 Bit Score: 48.55 E-value: 7.83e-08
10 20 30
....*....|....*....|....*....|....
gi 115256001 254 QKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALS 287
Cdd:pfam02151 1 KKLIKELEEEMEEAAENEDFEKAAKLRDQINALK 34
|
|
| ligA |
PRK07956 |
NAD-dependent DNA ligase LigA; Validated |
630-678 |
9.41e-06 |
|
NAD-dependent DNA ligase LigA; Validated
Pssm-ID: 236137 [Multi-domain] Cd Length: 665 Bit Score: 48.97 E-value: 9.41e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 115256001 630 IGPSRKRALLQHFGTAKAVSRAALSDLMAVEGISEAVARQVYNHFHDDA 678
Cdd:PRK07956 519 VGEKAAKALARHFGSLEALRAASEEELAAVEGVGEVVAQSIVEFFAVEE 567
|
|
| HHH_2 |
pfam12826 |
Helix-hairpin-helix motif; The HhH domain of DisA, a bacterial checkpoint control protein, is ... |
627-678 |
1.12e-05 |
|
Helix-hairpin-helix motif; The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.
Pssm-ID: 432812 [Multi-domain] Cd Length: 64 Bit Score: 43.28 E-value: 1.12e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 115256001 627 IGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVEGISEAVARQVYNHFHDDA 678
Cdd:pfam12826 8 IRHVGETTAKLLARRFGSLDALAEASLEELLEVDDIGPEIAQSIVEFFADPA 59
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
627-671 |
1.34e-05 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 48.33 E-value: 1.34e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 115256001 627 IGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVEGISEAVARQVY 671
Cdd:PRK13766 720 LPDVGPVLARNLLEHFGSVEAVMTASEEELMEVEGIGEKTAKRIR 764
|
|
| HHH_5 |
pfam14520 |
Helix-hairpin-helix domain; |
624-676 |
2.37e-05 |
|
Helix-hairpin-helix domain;
Pssm-ID: 434010 [Multi-domain] Cd Length: 57 Bit Score: 42.09 E-value: 2.37e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 115256001 624 LDEIGGIGPSRKRALLQH-FGTAKAVSRAALSDLMAVEGISEAVARQVYNHFHD 676
Cdd:pfam14520 4 LLSISGIGPKTALALLSAgIGTVEDLAEADVDELAEIPGIGEKTAQRIILELRD 57
|
|
| GIY-YIG_SF |
cd00719 |
GIY-YIG nuclease domain superfamily; The GIY-YIG nuclease domain superfamily includes a large ... |
69-138 |
3.25e-05 |
|
GIY-YIG nuclease domain superfamily; The GIY-YIG nuclease domain superfamily includes a large and diverse group of proteins involved in many cellular processes, such as class I homing GIY-YIG family endonucleases, prokaryotic nucleotide excision repair proteins UvrC and Cho, type II restriction enzymes, the endonuclease/reverse transcriptase of eukaryotic retrotransposable elements, and a family of eukaryotic enzymes that repair stalled replication forks. All of these members contain a conserved GIY-YIG nuclease domain that may serve as a scaffold for the coordination of a divalent metal ion required for catalysis of the phosphodiester bond cleavage. By combining with different specificity, targeting, or other domains, the GIY-YIG nucleases may perform different functions.
Pssm-ID: 198380 [Multi-domain] Cd Length: 69 Bit Score: 42.35 E-value: 3.25e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115256001 69 GVYRMFNAEGDVLYVGKARSLKKRVNNYavgrvHSNRIAQMVRQTANMEF----VTTRTETEALLLEANLIKRL 138
Cdd:cd00719 1 GVYVLYDEDNGLIYVGQTKNLRNRIKEH-----LRKQRSDWTKGLKPFEIlyleVAPEAESELLDLEAALIKKL 69
|
|
| Lig |
COG0272 |
NAD-dependent DNA ligase [Replication, recombination and repair]; |
627-678 |
6.84e-05 |
|
NAD-dependent DNA ligase [Replication, recombination and repair];
Pssm-ID: 440042 [Multi-domain] Cd Length: 668 Bit Score: 46.17 E-value: 6.84e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 115256001 627 IGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVEGISEAVARQVYNHFHDDA 678
Cdd:COG0272 517 IRHVGETTAKLLARHFGSLDALMAASEEELAAVDGIGPVVAESIVEFFAEPH 568
|
|
| UvrB |
COG0556 |
Excinuclease UvrABC helicase subunit UvrB [Replication, recombination and repair]; |
230-286 |
8.81e-05 |
|
Excinuclease UvrABC helicase subunit UvrB [Replication, recombination and repair];
Pssm-ID: 440322 [Multi-domain] Cd Length: 657 Bit Score: 45.77 E-value: 8.81e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 115256001 230 THEVSDGGYGELVQEAKDFLSGKS-QKVKSHMAEAMNQAAEDLDFERAAIYRDRLAAL 286
Cdd:COG0556 597 TYEADEETEELVAEADAAKLSKEElEKLIKELEKEMKEAAKNLEFEEAARLRDEIKEL 654
|
|
| PRK05298 |
PRK05298 |
excinuclease ABC subunit UvrB; |
262-286 |
1.95e-04 |
|
excinuclease ABC subunit UvrB;
Pssm-ID: 235395 [Multi-domain] Cd Length: 652 Bit Score: 44.65 E-value: 1.95e-04
10 20
....*....|....*....|....*
gi 115256001 262 EAMNQAAEDLDFERAAIYRDRLAAL 286
Cdd:PRK05298 620 KQMKEAAKNLEFEEAARLRDEIKEL 644
|
|
| Smf |
COG0758 |
Predicted Rossmann fold nucleotide-binding protein DprA/Smf involved in DNA uptake ... |
627-679 |
2.56e-04 |
|
Predicted Rossmann fold nucleotide-binding protein DprA/Smf involved in DNA uptake [Replication, recombination and repair];
Pssm-ID: 440521 [Multi-domain] Cd Length: 360 Bit Score: 43.92 E-value: 2.56e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 115256001 627 IGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVeGISEAVARQVYNHFHDDAA 679
Cdd:COG0758 13 VPGVGPVTLRRLLAHFGSAEAALEALPSELARL-GLGEKAAEAIRARPDLADA 64
|
|
| DisA |
COG1623 |
c-di-AMP synthetase DisA, contains DisA_N, linker and DNA-binding domains [Signal transduction ... |
636-670 |
2.53e-03 |
|
c-di-AMP synthetase DisA, contains DisA_N, linker and DNA-binding domains [Signal transduction mechanisms];
Pssm-ID: 441230 [Multi-domain] Cd Length: 353 Bit Score: 40.50 E-value: 2.53e-03
10 20 30
....*....|....*....|....*....|....*
gi 115256001 636 RALLQHFGTAKAVSRAALSDLMAVEGISEAVARQV 670
Cdd:COG1623 302 ENLVEHFGSLQKLLAASIEELDDVEGIGEVRARAI 336
|
|
| PRK13482 |
PRK13482 |
DNA integrity scanning protein DisA; Provisional |
638-670 |
6.63e-03 |
|
DNA integrity scanning protein DisA; Provisional
Pssm-ID: 237395 [Multi-domain] Cd Length: 352 Bit Score: 39.38 E-value: 6.63e-03
10 20 30
....*....|....*....|....*....|...
gi 115256001 638 LLQHFGTAKAVSRAALSDLMAVEGISEAVARQV 670
Cdd:PRK13482 303 LVEHFGSLQGLLAASIEDLDEVEGIGEVRARAI 335
|
|
| |
