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Conserved domains on  [gi|2474876906|emb|CAI8348327|]
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MAG: Serine hydroxymethyltransferase [uncultured Bacteroidetes bacterium]

Protein Classification

serine hydroxymethyltransferase( domain architecture ID 10011056)

serine hydroxymethyltransferase catalyzes the reversible, simultaneous conversions of L-serine to glycine (retro-aldol cleavage) and tetrahydrofolate to 5,10-methylenetetrahydrofolate (hydrolysis)

EC:  2.1.2.1
Gene Symbol:  glyA
Gene Ontology:  GO:0004372|GO:0030170|GO:0070905|GO:0008270|GO:0019264
PubMed:  12686103|2201683
SCOP:  4000675

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
glyA PRK00011
serine hydroxymethyltransferase; Reviewed
 4-423 0e+00

serine hydroxymethyltransferase; Reviewed


:

Pssm-ID: 234571  Cd Length: 416  Bit Score: 707.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906   4 QDTAVFDLIKEEEQRQLNGIELIASENFTSPAVMEATGSVLTNKYAEGYPGKRYYGGCEVVDEVERIAIERAKELFGAAY 83
Cdd:PRK00011    9 YDPEIADAIEQELKRQEEHIELIASENFVSPAVMEAQGSVLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKELFGAEY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  84 ANVQPHSGSQANTAVFHAFLKPGDKILGFDLSHGGHLTHGSPVNFSGRLYEAHFYGVQEDTGRLDYDNILKIAQEVKPQM 163
Cdd:PRK00011   89 ANVQPHSGSQANAAVYFALLKPGDTILGMDLAHGGHLTHGSPVNFSGKLYNVVSYGVDEETGLIDYDEVEKLALEHKPKL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 164 LIAGASAYSRDIDFAKFREIADAVGAFLLADISHPSGMIATGMLSNPIPHCHVVTTTTHKTLRGPRGGLILMgedfdnpf 243
Cdd:PRK00011  169 IIAGASAYSRPIDFKRFREIADEVGAYLMVDMAHIAGLVAAGVHPSPVPHADVVTTTTHKTLRGPRGGLILT-------- 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 244 gltlkngNPQKMSHLLNMAVFPGNQGGPLMHVIAGKAVAFQEALDPSFKSYMEQVRKNAQAMAAAFVAKGYHLISGGTDN 323
Cdd:PRK00011  241 -------NDEELAKKINSAVFPGIQGGPLMHVIAAKAVAFKEALEPEFKEYAQQVVKNAKALAEALAERGFRVVSGGTDN 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 324 HMMLIDLRNKNITGKDAEKALVSAEITANKNMVPFDDKSPFVTSGIRVGAAAITTRGLKEAEMATIVDFIDRVIQNPDNE 403
Cdd:PRK00011  314 HLVLVDLRSKGLTGKEAEAALEEANITVNKNAVPFDPRSPFVTSGIRIGTPAITTRGFKEAEMKEIAELIADVLDNPDDE 393

                         410       420
                  ....*....|....*....|
gi 2474876906 404 AELQAVAQEVHSLMEGRPLF 423
Cdd:PRK00011  394 AVIEEVKEEVKELCKRFPLY 413
 
Name Accession Description Interval E-value
glyA PRK00011
serine hydroxymethyltransferase; Reviewed
 4-423 0e+00

serine hydroxymethyltransferase; Reviewed


Pssm-ID: 234571  Cd Length: 416  Bit Score: 707.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906   4 QDTAVFDLIKEEEQRQLNGIELIASENFTSPAVMEATGSVLTNKYAEGYPGKRYYGGCEVVDEVERIAIERAKELFGAAY 83
Cdd:PRK00011    9 YDPEIADAIEQELKRQEEHIELIASENFVSPAVMEAQGSVLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKELFGAEY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  84 ANVQPHSGSQANTAVFHAFLKPGDKILGFDLSHGGHLTHGSPVNFSGRLYEAHFYGVQEDTGRLDYDNILKIAQEVKPQM 163
Cdd:PRK00011   89 ANVQPHSGSQANAAVYFALLKPGDTILGMDLAHGGHLTHGSPVNFSGKLYNVVSYGVDEETGLIDYDEVEKLALEHKPKL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 164 LIAGASAYSRDIDFAKFREIADAVGAFLLADISHPSGMIATGMLSNPIPHCHVVTTTTHKTLRGPRGGLILMgedfdnpf 243
Cdd:PRK00011  169 IIAGASAYSRPIDFKRFREIADEVGAYLMVDMAHIAGLVAAGVHPSPVPHADVVTTTTHKTLRGPRGGLILT-------- 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 244 gltlkngNPQKMSHLLNMAVFPGNQGGPLMHVIAGKAVAFQEALDPSFKSYMEQVRKNAQAMAAAFVAKGYHLISGGTDN 323
Cdd:PRK00011  241 -------NDEELAKKINSAVFPGIQGGPLMHVIAAKAVAFKEALEPEFKEYAQQVVKNAKALAEALAERGFRVVSGGTDN 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 324 HMMLIDLRNKNITGKDAEKALVSAEITANKNMVPFDDKSPFVTSGIRVGAAAITTRGLKEAEMATIVDFIDRVIQNPDNE 403
Cdd:PRK00011  314 HLVLVDLRSKGLTGKEAEAALEEANITVNKNAVPFDPRSPFVTSGIRIGTPAITTRGFKEAEMKEIAELIADVLDNPDDE 393

                         410       420
                  ....*....|....*....|
gi 2474876906 404 AELQAVAQEVHSLMEGRPLF 423
Cdd:PRK00011  394 AVIEEVKEEVKELCKRFPLY 413
GlyA COG0112
Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Glycine/serine ...
 4-423 0e+00

Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Glycine/serine hydroxymethyltransferase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 439882  Cd Length: 414  Bit Score: 700.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906   4 QDTAVFDLIKEEEQRQLNGIELIASENFTSPAVMEATGSVLTNKYAEGYPGKRYYGGCEVVDEVERIAIERAKELFGAAY 83
Cdd:COG0112     8 VDPEIAEAIEKELERQEEGIELIASENFVSPAVLEAQGSVLTNKYAEGYPGKRYYGGCEYVDEVEQLAIERAKELFGAEH 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  84 ANVQPHSGSQANTAVFHAFLKPGDKILGFDLSHGGHLTHGSPVNFSGRLYEAHFYGVQEDTGRLDYDNILKIAQEVKPQM 163
Cdd:COG0112    88 ANVQPHSGSQANLAVYFALLKPGDTILGMDLAHGGHLTHGSPVNFSGKGYNVVSYGVDPETGLIDYDEVRKLALEHKPKL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 164 LIAGASAYSRDIDFAKFREIADAVGAFLLADISHPSGMIATGMLSNPIPHCHVVTTTTHKTLRGPRGGLILMGEDFdnpf 243
Cdd:COG0112   168 IIAGASAYPRPIDFARFREIADEVGAYLMVDMAHIAGLVAGGLHPSPVPGADVVTTTTHKTLRGPRGGLILCNEEL---- 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 244 gltlkngnpqkmSHLLNMAVFPGNQGGPLMHVIAGKAVAFQEALDPSFKSYMEQVRKNAQAMAAAFVAKGYHLISGGTDN 323
Cdd:COG0112   244 ------------AKKIDSAVFPGLQGGPLMHVIAAKAVAFKEALTPEFKEYAKQVVKNAKALAEALAERGFRVVSGGTDN 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 324 HMMLIDLRNKNITGKDAEKALVSAEITANKNMVPFDDKSPFVTSGIRVGAAAITTRGLKEAEMATIVDFIDRVIQNPDNE 403
Cdd:COG0112   312 HLVLVDLRSKGLTGKEAEKALERAGITVNKNAIPFDPRSPFVTSGIRIGTPAVTTRGMKEAEMEEIAELIADVLDNPEDE 391

                         410       420
                  ....*....|....*....|
gi 2474876906 404 AELQAVAQEVHSLMEGRPLF 423
Cdd:COG0112   392 AVLAEVREEVKELCKRFPLY 411
SHMT cd00378
Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate ...
 4-416 0e+00

Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl group of N5, N10-methylene tetrahydrofolate to glycine resulting in the formation of serine and tetrahydrofolate. Both eukaryotic and prokaryotic SHMT enzymes form tight obligate homodimers; the mammalian enzyme forms a homotetramer comprising four pyridoxal phosphate-bound active sites.


Pssm-ID: 99733  Cd Length: 402  Bit Score: 576.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906   4 QDTAVFDLIKEEEQRQLNGIELIASENFTSPAVMEATGSVLTNKYAEGYPGKRYYGGCEVVDEVERIAIERAKELFGAAY 83
Cdd:cd00378     3 VDPEIAEIIKKENERQRETLELIASENFTSPAVMEAMGSDLTNKYAEGYPGKRYYGGCEYVDEIEDLAIERAKKLFGAEY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  84 ANVQPHSGSQANTAVFHAFLKPGDKILGFDLSHGGHLTHGSP--VNFSGRLYEAHFYGVQEDTGRLDYDNILKIAQEVKP 161
Cdd:cd00378    83 ANVQPHSGSQANLAVYFALLEPGDTIMGLDLSHGGHLTHGSFtkVSASGKLFESVPYGVDPETGLIDYDALEKMALEFKP 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 162 QMLIAGASAYSRDIDFAKFREIADAVGAFLLADISHPSGMIATGMLSNPIPHCHVVTTTTHKTLRGPRGGLILMGEDfdn 241
Cdd:cd00378   163 KLIVAGASAYPRPIDFKRFREIADEVGAYLLVDMAHVAGLVAGGVFPNPLPGADVVTTTTHKTLRGPRGGLILTRKG--- 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 242 pfgltlkngnpqKMSHLLNMAVFPGNQGGPLMHVIAGKAVAFQEALDPSFKSYMEQVRKNAQAMAAAFVAKGYHLISGGT 321
Cdd:cd00378   240 ------------ELAKKINSAVFPGLQGGPHLHVIAAKAVALKEALEPEFKAYAKQVVENAKALAEALKERGFKVVSGGT 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 322 DNHMMLIDLRNKNITGKDAEKALVSAEITANKNMVPFDDKSPFVTSGIRVGAAAITTRGLKEAEMATIVDFIDRVIQNPD 401
Cdd:cd00378   308 DNHLVLVDLRPKGITGKAAEDALEEAGITVNKNTLPWDPSSPFVPSGIRIGTPAMTTRGMGEEEMEEIADFIARALKDAE 387

                         410
                  ....*....|....*
gi 2474876906 402 NEAELQAVAQEVHSL 416
Cdd:cd00378   388 DVAVAEEVRKEVAEL 402
SHMT pfam00464
Serine hydroxymethyltransferase;
4-393 0e+00

Serine hydroxymethyltransferase;


Pssm-ID: 395372  Cd Length: 399  Bit Score: 538.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906   4 QDTAVFDLIKEEEQRQLNGIELIASENFTSPAVMEATGSVLTNKYAEGYPGKRYYGGCEVVDEVERIAIERAKELFGA-- 81
Cdd:pfam00464   4 SDPEVFDIIKKEKERQREGIELIASENFTSRAVMEALGSVLTNKYSEGYPGKRYYGGCEHVDEIETLCQDRALEAFGLdp 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  82 --AYANVQPHSGSQANTAVFHAFLKPGDKILGFDLSHGGHLTHGSPVNF-----SGRLYEAHFYGVQEDTGRLDYDNILK 154
Cdd:pfam00464  84 akWGVNVQPLSGSPANLAVYTALLEPGDRIMGLDLPHGGHLTHGYPVNSkkisaSSKFFESMPYGVDPETGYIDYDQLEK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 155 IAQEVKPQMLIAGASAYSRDIDFAKFREIADAVGAFLLADISHPSGMIATGMLSNPIPHCHVVTTTTHKTLRGPRGGLIL 234
Cdd:pfam00464 164 NAKLFRPKLIVAGTSAYSRLIDYARFREIADEVGAYLMVDMAHISGLVAAGVIPSPFPYADVVTTTTHKTLRGPRGGMIF 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 235 mgedFDNPFGLTLKNGN--PQKMSHLLNMAVFPGNQGGPLMHVIAGKAVAFQEALDPSFKSYMEQVRKNAQAMAAAFVAK 312
Cdd:pfam00464 244 ----YRKGVKSVDKTGKeiLYELEKKINSAVFPGLQGGPHNHVIAAKAVALKQALTPEFKEYQQQVVKNAKALAEALTER 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 313 GYHLISGGTDNHMMLIDLRNKNITGKDAEKALVSAEITANKNMVPFdDKSPFVTSGIRVGAAAITTRGLKEAEMATIVDF 392
Cdd:pfam00464 320 GYKLVSGGTDNHLVLVDLRPKGLDGARAEKVLEAANITANKNTIPG-DKSAFVPSGLRLGTPALTSRGFGEADFEKVAGF 398


                  .
gi 2474876906 393 I 393
Cdd:pfam00464 399 I 399
 
Name Accession Description Interval E-value
glyA PRK00011
serine hydroxymethyltransferase; Reviewed
 4-423 0e+00

serine hydroxymethyltransferase; Reviewed


Pssm-ID: 234571  Cd Length: 416  Bit Score: 707.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906   4 QDTAVFDLIKEEEQRQLNGIELIASENFTSPAVMEATGSVLTNKYAEGYPGKRYYGGCEVVDEVERIAIERAKELFGAAY 83
Cdd:PRK00011    9 YDPEIADAIEQELKRQEEHIELIASENFVSPAVMEAQGSVLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRAKELFGAEY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  84 ANVQPHSGSQANTAVFHAFLKPGDKILGFDLSHGGHLTHGSPVNFSGRLYEAHFYGVQEDTGRLDYDNILKIAQEVKPQM 163
Cdd:PRK00011   89 ANVQPHSGSQANAAVYFALLKPGDTILGMDLAHGGHLTHGSPVNFSGKLYNVVSYGVDEETGLIDYDEVEKLALEHKPKL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 164 LIAGASAYSRDIDFAKFREIADAVGAFLLADISHPSGMIATGMLSNPIPHCHVVTTTTHKTLRGPRGGLILMgedfdnpf 243
Cdd:PRK00011  169 IIAGASAYSRPIDFKRFREIADEVGAYLMVDMAHIAGLVAAGVHPSPVPHADVVTTTTHKTLRGPRGGLILT-------- 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 244 gltlkngNPQKMSHLLNMAVFPGNQGGPLMHVIAGKAVAFQEALDPSFKSYMEQVRKNAQAMAAAFVAKGYHLISGGTDN 323
Cdd:PRK00011  241 -------NDEELAKKINSAVFPGIQGGPLMHVIAAKAVAFKEALEPEFKEYAQQVVKNAKALAEALAERGFRVVSGGTDN 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 324 HMMLIDLRNKNITGKDAEKALVSAEITANKNMVPFDDKSPFVTSGIRVGAAAITTRGLKEAEMATIVDFIDRVIQNPDNE 403
Cdd:PRK00011  314 HLVLVDLRSKGLTGKEAEAALEEANITVNKNAVPFDPRSPFVTSGIRIGTPAITTRGFKEAEMKEIAELIADVLDNPDDE 393

                         410       420
                  ....*....|....*....|
gi 2474876906 404 AELQAVAQEVHSLMEGRPLF 423
Cdd:PRK00011  394 AVIEEVKEEVKELCKRFPLY 413
GlyA COG0112
Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Glycine/serine ...
 4-423 0e+00

Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Glycine/serine hydroxymethyltransferase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 439882  Cd Length: 414  Bit Score: 700.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906   4 QDTAVFDLIKEEEQRQLNGIELIASENFTSPAVMEATGSVLTNKYAEGYPGKRYYGGCEVVDEVERIAIERAKELFGAAY 83
Cdd:COG0112     8 VDPEIAEAIEKELERQEEGIELIASENFVSPAVLEAQGSVLTNKYAEGYPGKRYYGGCEYVDEVEQLAIERAKELFGAEH 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  84 ANVQPHSGSQANTAVFHAFLKPGDKILGFDLSHGGHLTHGSPVNFSGRLYEAHFYGVQEDTGRLDYDNILKIAQEVKPQM 163
Cdd:COG0112    88 ANVQPHSGSQANLAVYFALLKPGDTILGMDLAHGGHLTHGSPVNFSGKGYNVVSYGVDPETGLIDYDEVRKLALEHKPKL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 164 LIAGASAYSRDIDFAKFREIADAVGAFLLADISHPSGMIATGMLSNPIPHCHVVTTTTHKTLRGPRGGLILMGEDFdnpf 243
Cdd:COG0112   168 IIAGASAYPRPIDFARFREIADEVGAYLMVDMAHIAGLVAGGLHPSPVPGADVVTTTTHKTLRGPRGGLILCNEEL---- 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 244 gltlkngnpqkmSHLLNMAVFPGNQGGPLMHVIAGKAVAFQEALDPSFKSYMEQVRKNAQAMAAAFVAKGYHLISGGTDN 323
Cdd:COG0112   244 ------------AKKIDSAVFPGLQGGPLMHVIAAKAVAFKEALTPEFKEYAKQVVKNAKALAEALAERGFRVVSGGTDN 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 324 HMMLIDLRNKNITGKDAEKALVSAEITANKNMVPFDDKSPFVTSGIRVGAAAITTRGLKEAEMATIVDFIDRVIQNPDNE 403
Cdd:COG0112   312 HLVLVDLRSKGLTGKEAEKALERAGITVNKNAIPFDPRSPFVTSGIRIGTPAVTTRGMKEAEMEEIAELIADVLDNPEDE 391

                         410       420
                  ....*....|....*....|
gi 2474876906 404 AELQAVAQEVHSLMEGRPLF 423
Cdd:COG0112   392 AVLAEVREEVKELCKRFPLY 411
PRK13034 PRK13034
serine hydroxymethyltransferase; Reviewed
 4-423 0e+00

serine hydroxymethyltransferase; Reviewed


Pssm-ID: 237280  Cd Length: 416  Bit Score: 621.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906   4 QDTAVFDLIKEEEQRQLNGIELIASENFTSPAVMEATGSVLTNKYAEGYPGKRYYGGCEVVDEVERIAIERAKELFGAAY 83
Cdd:PRK13034   12 YDDEVFAAINKELERQQDHLELIASENFTSPAVMEAQGSVLTNKYAEGYPGKRYYGGCEFVDEVEALAIERAKQLFGCDY 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  84 ANVQPHSGSQANTAVFHAFLKPGDKILGFDLSHGGHLTHGSPVNFSGRLYEAHFYGVQEDTGRLDYDNILKIAQEVKPQM 163
Cdd:PRK13034   92 ANVQPHSGSQANGAVYLALLKPGDTILGMSLSHGGHLTHGAKVSLSGKWYNAVQYGVDRLTGLIDYDEVEELAKEHKPKL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 164 LIAGASAYSRDIDFAKFREIADAVGAFLLADISHPSGMIATGMLSNPIPHCHVVTTTTHKTLRGPRGGLILMgedfdnpf 243
Cdd:PRK13034  172 IIAGFSAYPRELDFARFREIADEVGALLMVDMAHIAGLVAAGEHPNPFPHAHVVTTTTHKTLRGPRGGMILT-------- 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 244 gltlkngNPQKMSHLLNMAVFPGNQGGPLMHVIAGKAVAFQEALDPSFKSYMEQVRKNAQAMAAAFVAKGYHLISGGTDN 323
Cdd:PRK13034  244 -------NDEEIAKKINSAVFPGLQGGPLMHVIAAKAVAFGEALQPEFKTYAKQVIANAQALAEVLKERGYDLVSGGTDN 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 324 HMMLIDLRNKNITGKDAEKALVSAEITANKNMVPFDDKSPFVTSGIRVGAAAITTRGLKEAEMATIVDFIDRVIQNPDNE 403
Cdd:PRK13034  317 HLLLVDLRPKGLSGKDAEQALERAGITVNKNTVPGDTESPFVTSGIRIGTPAGTTRGFGEAEFREIANWILDVLDDLGNA 396

                         410       420
                  ....*....|....*....|
gi 2474876906 404 AELQAVAQEVHSLMEGRPLF 423
Cdd:PRK13034  397 ALEQRVRKEVKALCSRFPIY 416
SHMT cd00378
Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate ...
 4-416 0e+00

Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl group of N5, N10-methylene tetrahydrofolate to glycine resulting in the formation of serine and tetrahydrofolate. Both eukaryotic and prokaryotic SHMT enzymes form tight obligate homodimers; the mammalian enzyme forms a homotetramer comprising four pyridoxal phosphate-bound active sites.


Pssm-ID: 99733  Cd Length: 402  Bit Score: 576.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906   4 QDTAVFDLIKEEEQRQLNGIELIASENFTSPAVMEATGSVLTNKYAEGYPGKRYYGGCEVVDEVERIAIERAKELFGAAY 83
Cdd:cd00378     3 VDPEIAEIIKKENERQRETLELIASENFTSPAVMEAMGSDLTNKYAEGYPGKRYYGGCEYVDEIEDLAIERAKKLFGAEY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  84 ANVQPHSGSQANTAVFHAFLKPGDKILGFDLSHGGHLTHGSP--VNFSGRLYEAHFYGVQEDTGRLDYDNILKIAQEVKP 161
Cdd:cd00378    83 ANVQPHSGSQANLAVYFALLEPGDTIMGLDLSHGGHLTHGSFtkVSASGKLFESVPYGVDPETGLIDYDALEKMALEFKP 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 162 QMLIAGASAYSRDIDFAKFREIADAVGAFLLADISHPSGMIATGMLSNPIPHCHVVTTTTHKTLRGPRGGLILMGEDfdn 241
Cdd:cd00378   163 KLIVAGASAYPRPIDFKRFREIADEVGAYLLVDMAHVAGLVAGGVFPNPLPGADVVTTTTHKTLRGPRGGLILTRKG--- 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 242 pfgltlkngnpqKMSHLLNMAVFPGNQGGPLMHVIAGKAVAFQEALDPSFKSYMEQVRKNAQAMAAAFVAKGYHLISGGT 321
Cdd:cd00378   240 ------------ELAKKINSAVFPGLQGGPHLHVIAAKAVALKEALEPEFKAYAKQVVENAKALAEALKERGFKVVSGGT 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 322 DNHMMLIDLRNKNITGKDAEKALVSAEITANKNMVPFDDKSPFVTSGIRVGAAAITTRGLKEAEMATIVDFIDRVIQNPD 401
Cdd:cd00378   308 DNHLVLVDLRPKGITGKAAEDALEEAGITVNKNTLPWDPSSPFVPSGIRIGTPAMTTRGMGEEEMEEIADFIARALKDAE 387

                         410
                  ....*....|....*
gi 2474876906 402 NEAELQAVAQEVHSL 416
Cdd:cd00378   388 DVAVAEEVRKEVAEL 402
SHMT pfam00464
Serine hydroxymethyltransferase;
4-393 0e+00

Serine hydroxymethyltransferase;


Pssm-ID: 395372  Cd Length: 399  Bit Score: 538.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906   4 QDTAVFDLIKEEEQRQLNGIELIASENFTSPAVMEATGSVLTNKYAEGYPGKRYYGGCEVVDEVERIAIERAKELFGA-- 81
Cdd:pfam00464   4 SDPEVFDIIKKEKERQREGIELIASENFTSRAVMEALGSVLTNKYSEGYPGKRYYGGCEHVDEIETLCQDRALEAFGLdp 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  82 --AYANVQPHSGSQANTAVFHAFLKPGDKILGFDLSHGGHLTHGSPVNF-----SGRLYEAHFYGVQEDTGRLDYDNILK 154
Cdd:pfam00464  84 akWGVNVQPLSGSPANLAVYTALLEPGDRIMGLDLPHGGHLTHGYPVNSkkisaSSKFFESMPYGVDPETGYIDYDQLEK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 155 IAQEVKPQMLIAGASAYSRDIDFAKFREIADAVGAFLLADISHPSGMIATGMLSNPIPHCHVVTTTTHKTLRGPRGGLIL 234
Cdd:pfam00464 164 NAKLFRPKLIVAGTSAYSRLIDYARFREIADEVGAYLMVDMAHISGLVAAGVIPSPFPYADVVTTTTHKTLRGPRGGMIF 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 235 mgedFDNPFGLTLKNGN--PQKMSHLLNMAVFPGNQGGPLMHVIAGKAVAFQEALDPSFKSYMEQVRKNAQAMAAAFVAK 312
Cdd:pfam00464 244 ----YRKGVKSVDKTGKeiLYELEKKINSAVFPGLQGGPHNHVIAAKAVALKQALTPEFKEYQQQVVKNAKALAEALTER 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 313 GYHLISGGTDNHMMLIDLRNKNITGKDAEKALVSAEITANKNMVPFdDKSPFVTSGIRVGAAAITTRGLKEAEMATIVDF 392
Cdd:pfam00464 320 GYKLVSGGTDNHLVLVDLRPKGLDGARAEKVLEAANITANKNTIPG-DKSAFVPSGLRLGTPALTSRGFGEADFEKVAGF 398


                  .
gi 2474876906 393 I 393
Cdd:pfam00464 399 I 399
PTZ00094 PTZ00094
serine hydroxymethyltransferase; Provisional
 4-398 1.76e-165

serine hydroxymethyltransferase; Provisional


Pssm-ID: 240264  Cd Length: 452  Bit Score: 472.55  E-value: 1.76e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906   4 QDTAVFDLIKEEEQRQLNGIELIASENFTSPAVMEATGSVLTNKYAEGYPGKRYYGGCEVVDEVERIAIERAKELFGAAY 83
Cdd:PTZ00094   18 ADPELYELIEKEKERQIEGLELIASENFTSRAVLECLGSCFTNKYAEGLPGNRYYGGNEVVDKIENLCQKRALEAFGLDP 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  84 ----ANVQPHSGSQANTAVFHAFLKPGDKILGFDLSHGGHLTHG-----SPVNFSGRLYEAHFYGVQEDtGRLDYDNILK 154
Cdd:PTZ00094   98 eewgVNVQPYSGSPANFAVYTALLQPHDRIMGLDLPSGGHLTHGfytakKKVSATSIYFESLPYQVNEK-GLIDYDKLEE 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 155 IAQEVKPQMLIAGASAYSRDIDFAKFREIADAVGAFLLADISHPSGMIATGMLSNPIPHCHVVTTTTHKTLRGPRGGLIl 234
Cdd:PTZ00094  177 LAKAFRPKLIIAGASAYPRDIDYKRFREICDSVGAYLMADIAHTSGLVAAGVLPSPFPYADVVTTTTHKSLRGPRSGLI- 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 235 mgedFDNpfgltlKNGNPQKMShLLNMAVFPGNQGGPLMHVIAGKAVAFQEALDPSFKSYMEQVRKNAQAMAAAFVAKGY 314
Cdd:PTZ00094  256 ----FYR------KKVKPDIEN-KINEAVFPGLQGGPHNHQIAAIAVQLKEVQSPEWKEYAKQVLKNAKALAAALEKRGY 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 315 HLISGGTDNHMMLIDLRNKNITGKDAEKALVSAEITANKNMVPFdDKSPFVTSGIRVGAAAITTRGLKEAEMATIVDFID 394
Cdd:PTZ00094  325 DLVTGGTDNHLVLVDLRPFGITGSKMEKLLDAVNISVNKNTIPG-DKSALNPSGVRLGTPALTTRGAKEKDFKFVADFLD 403


                  ....
gi 2474876906 395 RVIQ 398
Cdd:PTZ00094  404 RAVK 407
PLN03226 PLN03226
serine hydroxymethyltransferase; Provisional
 4-398 1.30e-156

serine hydroxymethyltransferase; Provisional


Pssm-ID: 215639  Cd Length: 475  Bit Score: 450.97  E-value: 1.30e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906   4 QDTAVFDLIKEEEQRQLNGIELIASENFTSPAVMEATGSVLTNKYAEGYPGKRYYGGCEVVDEVERIAIERAKELFGAAY 83
Cdd:PLN03226   18 VDPEIADIIEKEKRRQWKGLELIASENFTSRAVMEALGSCLTNKYSEGLPGARYYGGNEYIDQIETLCQKRALEAFRLDP 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  84 A----NVQPHSGSQANTAVFHAFLKPGDKILGFDLSHGGHLTHG-----SPVNFSGRLYEAHFYGVQEDTGRLDYDNILK 154
Cdd:PLN03226   98 EkwgvNVQPLSGSPANFAVYTALLQPHDRIMGLDLPHGGHLSHGyqtdgKKISATSIYFESMPYRLDESTGLIDYDKLEK 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 155 IAQEVKPQMLIAGASAYSRDIDFAKFREIADAVGAFLLADISHPSGMIATGMLSNPIPHCHVVTTTTHKTLRGPRGGLIL 234
Cdd:PLN03226  178 KAMLFRPKLIIAGASAYPRDWDYARMRKIADKVGALLMCDMAHISGLVAAQEAASPFEYCDVVTTTTHKSLRGPRGGMIF 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 235 MGEDFDNPfgltlKNGNPQKMSHL---LNMAVFPGNQGGPLMHVIAGKAVAFQEALDPSFKSYMEQVRKNAQAMAAAFVA 311
Cdd:PLN03226  258 FRKGPKPP-----KGQGEGAVYDYedkINFAVFPGLQGGPHNHTIAALAVALKQAMTPEFKAYQKQVKANAAALANRLMS 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 312 KGYHLISGGTDNHMMLIDLRNKNITGKDAEKALVSAEITANKNMVPfDDKSPFVTSGIRVGAAAITTRGLKEAEMATIVD 391
Cdd:PLN03226  333 KGYKLVTGGTDNHLVLWDLRPLGLTGSRVEKVLDLAHITLNKNAVP-GDSSALVPGGVRIGTPAMTSRGLVEKDFEKVAE 411


                  ....*..
gi 2474876906 392 FIDRVIQ 398
Cdd:PLN03226  412 FLHRAVT 418
PRK13580 PRK13580
glycine hydroxymethyltransferase;
8-423 3.25e-139

glycine hydroxymethyltransferase;


Pssm-ID: 184161  Cd Length: 493  Bit Score: 407.12  E-value: 3.25e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906   8 VFDLIKEEEQRQLNGIELIASENFTSPAVMEATGSVLTNKYAEGYPGKRYYGGCEVVDEVERIAIERAKELFGAAYANVQ 87
Cdd:PRK13580   37 IAEAIRQELADQRSSLKLIASENYSSLAVQLAMGNLLTDKYAEGTPGHRFYAGCQNVDTVEWEAAEHAKELFGAEHAYVQ 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  88 PHSGSQANTAVFHAFL------------------------------KPGD-KILGFDLSHGGHLTHGSPVNFSGRLYEAH 136
Cdd:PRK13580  117 PHSGADANLVAFWAILahkvespaleklgaktvndlteedwealraELGNqRLLGMSLDSGGHLTHGFRPNISGKMFHQR 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 137 FYGVQEDTGRLDYDNILKIAQEVKPQMLIAGASAYSRDIDFAKFREIADAVGAFLLADISHPSGMIATGMLS---NPIPH 213
Cdd:PRK13580  197 SYGVDPDTGLLDYDEIAALAREFKPLILVAGYSAYPRRVNFAKLREIADEVGAVLMVDMAHFAGLVAGKVFTgdeDPVPH 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 214 CHVVTTTTHKTLRGPRGGLILMGEDFDNpfglTLKNGNPQKMshllnmavfpgnqGGPLMHVIAGKAVAFQEALDPSFKS 293
Cdd:PRK13580  277 ADIVTTTTHKTLRGPRGGLVLAKKEYAD----AVDKGCPLVL-------------GGPLPHVMAAKAVALAEARTPEFQK 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 294 YMEQVRKNAQAMAAAFVAKGYHLISGGTDNHMMLIDLRNKNITGKDAEKALVSAEITANKNMVPFDDKSPFVTSGIRVGA 373
Cdd:PRK13580  340 YAQQVVDNARALAEGFLKRGARLVTGGTDNHLVLIDVTSFGLTGRQAESALLDAGIVTNRNSIPSDPNGAWYTSGIRLGT 419

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2474876906 374 AAITTRGLKEAEMATIVDFIDRVIQN-----------PDNEAEL-QAVAQEVHS----LMEGRPLF 423
Cdd:PRK13580  420 PALTTLGMGSDEMDEVAELIVKVLSNttpgttaegapSKAKYELdEGVAQEVRArvaeLLARFPLY 485
PLN02271 PLN02271
serine hydroxymethyltransferase
 1-422 3.16e-113

serine hydroxymethyltransferase


Pssm-ID: 215153  Cd Length: 586  Bit Score: 343.71  E-value: 3.16e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906   1 MTLQDTAVFDLIKEEEQRQLNGIELIASENFTSPAVMEATGSVLTNKYAEGYPGKRYYGGCEVVDEVERIAIERAKELFG 80
Cdd:PLN02271  129 LPEADPDIHELMEKEKQRQFKGIELIASENFVCRAVMEALGSHLTNKYSEGMPGARYYTGNQYIDQIERLCCERALAAFG 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  81 AAYA----NVQPHSGSQANTAVFHAFLKPGDKILGFDLSHGGHLTHG--SP----VNFSGRLYEAHFYGVQEDTGRLDYD 150
Cdd:PLN02271  209 LDSEkwgvNVQPYSCTSANFAVYTGLLLPGDRIMGLDSPSGGHMSHGyyTPggkkVSGASIFFESLPYKVNPQTGYIDYD 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 151 NILKIAQEVKPQMLIAGASAYSRDIDFAKFREIADAVGAFLLADISHPSGMIATGMLSNPIPHCHVVTTTTHKTLRGPRG 230
Cdd:PLN02271  289 KLEEKALDFRPKILICGGSSYPREWDYARFRQIADKCGAVLMCDMAHISGLVAAKECVNPFDYCDIVTSTTHKSLRGPRG 368

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 231 GLILMgedfdnpfgltLKNGNPQKMSHLL---------------NMAVFPGNQGGPLMHVIAGKAVAFQEALDPSFKSYM 295
Cdd:PLN02271  369 GIIFY-----------RKGPKLRKQGMLLshgddnshydfeekiNFAVFPSLQGGPHNNHIAALAIALKQVATPEYKAYM 437

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 296 EQVRKNAQAMAAAFVAKGYHLISGGTDNHMMLIDLRNKNITGKDAEKALVSAEITANKNMVpFDDKSPFVTSGIRVGAAA 375
Cdd:PLN02271  438 QQVKKNAQALASALLRRKCRLVTGGTDNHLLLWDLTTLGLTGKNYEKVCEMCHITLNKTAI-FGDNGTISPGGVRIGTPA 516

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 2474876906 376 ITTRGLKEAEMATIVDFIDRViqnpdneAELQAVAQEVHSLMEGRPL 422
Cdd:PLN02271  517 MTSRGCLESDFETIADFLLRA-------AQIASAVQREHGKLQKEFL 556
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 71-235 2.87e-09

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 55.85  E-value: 2.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  71 AIERAKELFGA-AYANVQPHSGSQANTAVFHAFLKPGDKILGFDLSHGGHLTHGSPVNFsgrlYEAHFYGVQEDTGRLDY 149
Cdd:cd01494     5 LEEKLARLLQPgNDKAVFVPSGTGANEAALLALLGPGDEVIVDANGHGSRYWVAAELAG----AKPVPVPVDDAGYGGLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 150 DNIL---KIAQEVKPQMLIAGASAYSRDIDFAKFREIADAVGAFLLADISHPSGMIATGMLSNPIPHCHVVTTTTHKTLR 226
Cdd:cd01494    81 VAILeelKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPAPGVLIPEGGADVVTFSLHKNLG 160


                  ....*....
gi 2474876906 227 GPRGGLILM 235
Cdd:cd01494   161 GEGGGVVIV 169
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
31-197 9.22e-04

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 41.14  E-value: 9.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  31 FTSPAVMEATgsvltNKYAEGYPGKRYyGGCEVVDEVEriaiERAKELFGAAY-------ANVQPHSGSQAN-TAVFHAF 102
Cdd:pfam00155  14 DTLPAVAKAE-----KDALAGGTRNLY-GPTDGHPELR----EALAKFLGRSPvlkldreAAVVFGSGAGANiEALIFLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906 103 LKPGDKILGFDLSHGGHLT----HGSPVnfsgrlYEAHFYgvQEDTGRLDYDNIL-KIAQEVKpQMLIAGAS-----AYS 172
Cdd:pfam00155  84 ANPGDAILVPAPTYASYIRiarlAGGEV------VRYPLY--DSNDFHLDFDALEaALKEKPK-VVLHTSPHnptgtVAT 154

                         170       180
                  ....*....|....*....|....*
gi 2474876906 173 RDiDFAKFREIADAVGAFLLADISH 197
Cdd:pfam00155 155 LE-ELEKLLDLAKEHNILLLVDEAY 178
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 64-213 9.29e-03

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 37.95  E-value: 9.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474876906  64 VDEVERI--AIERAKelFGAAYAnvqphSGSQANTAVFHAFLKPGDKILGFDLSHGGhlTHgspvNFSGRLyeAHFYGVQ 141
Cdd:cd00614    42 VDALEKKlaALEGGE--AALAFS-----SGMAAISTVLLALLKAGDHVVASDDLYGG--TY----RLFERL--LPKLGIE 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2474876906 142 ED-TGRLDYDNILKIAQEvKPQMLIAG--ASAYSRDIDFAKFREIADAVGAFLLADishpsGMIATGMLSNPIPH 213
Cdd:cd00614   107 VTfVDPDDPEALEAAIKP-ETKLVYVEspTNPTLKVVDIEAIAELAHEHGALLVVD-----NTFATPYLQRPLEL 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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