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Conserved domains on  [gi|57997536|emb|CAI46013|]
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hypothetical protein [Homo sapiens]

Protein Classification

eukaryotic translation initiation factor 4 gamma 1( domain architecture ID 20299391)

eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) is a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome

CATH:  1.25.40.180
Gene Ontology:  GO:0003743|GO:0003723|GO:0031369|GO:0003729|GO:0006446|GO:0008135|GO:0008190|GO:0005524
PubMed:  10872469|12867079|9019810|27694156
SCOP:  4000569

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 761-986 5.14e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


:

Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.46  E-value: 5.14e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    761 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 840
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    841 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 920
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 57997536    921 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 986
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1438-1570 7.95e-58

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


:

Pssm-ID: 211397  Cd Length: 134  Bit Score: 195.97  E-value: 7.95e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536 1438 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1516
Cdd:cd11559    1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 57997536 1517 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1570
Cdd:cd11559   81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1242-1354 4.51e-37

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


:

Pssm-ID: 397128  Cd Length: 113  Bit Score: 135.48  E-value: 4.51e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   1242 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1321
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 57997536   1322 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1354
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 20-452 4.43e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 4.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    20 QPAFPPGQTAPVV----FSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVY--PAGSQVMMiPSQ 93
Cdd:PHA03247 2588 RPDAPPQSARPRApvddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRddPAPGRVSR-PRR 2666

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    94 ISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIap 173
Cdd:PHA03247 2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-- 2744

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   174 krerktirirdPNQGGKDITEeimsgARTASTPTPPQTGGGLEPQANGETPQVAViVRPDDRSQGAIIADRPGLPGPEHS 253
Cdd:PHA03247 2745 -----------PAGPATPGGP-----ARPARPPTTAGPPAPAPPAAPAAGPPRRL-TRPAVASLSESRESLPSPWDPADP 2807

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   254 PSESQPSSPSPTPSPSPVlePGSEPNLAVL-------SIPGDTMTTIQMSVEESTPISREtgePYRLSPEPTPLAEPILE 326
Cdd:PHA03247 2808 PAAVLAPAAALPPAASPA--GPLPPPTSAQptappppPGPPPPSLPLGGSVAPGGDVRRR---PPSRSPAAKPAAPARPP 2882

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   327 VEvTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPngmvPSEDLEPEVESSPELAPPPacPSESPVPIAPTAQPEELLNG 406
Cdd:PHA03247 2883 VR-RLARPAVSRSTESFALPPDQPERPPQPQAPPP----PQPQPQPPPPPQPQPPPPP--PPRPQPPLAPTTDPAGAGEP 2955

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 57997536   407 APSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPA 452
Cdd:PHA03247 2956 SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSL 3001
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
405-573 1.30e-05

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 49.87  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   405 NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELL 484
Cdd:PRK12323  369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   485 PPESTPIPANLSQNLEAAAATQ----VAVSVPKRRRKIKElnkKEAVGDLLDAFKEANPAVPEVenqPPAGSNPGPESEG 560
Cdd:PRK12323  449 APAPAPAAAPAAAARPAAAGPRpvaaAAAAAPARAAPAAA---PAPADDDPPPWEELPPEFASP---APAQPDAAPAGWV 522

                         170
                  ....*....|...
gi 57997536   561 SGVPPRPEEADET 573
Cdd:PRK12323  523 AESIPDPATADPD 535
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 761-986 5.14e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.46  E-value: 5.14e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    761 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 840
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    841 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 920
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 57997536    921 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 986
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1438-1570 7.95e-58

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 195.97  E-value: 7.95e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536 1438 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1516
Cdd:cd11559    1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 57997536 1517 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1570
Cdd:cd11559   81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 762-989 1.78e-53

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 186.03  E-value: 1.78e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536     762 RRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlKVPttekptvtvNFRK 841
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNA-KNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536     842 LLLNRCQKEFEKDkdddevfekkqkemdeaataeergrlkeeLEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV 921
Cdd:smart00543   72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 57997536     922 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKT---SSRIRFMLQDVLDLRGSN 989
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELRKNK 200
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1242-1354 4.51e-37

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 135.48  E-value: 4.51e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   1242 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1321
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 57997536   1322 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1354
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1242-1354 4.55e-36

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 132.75  E-value: 4.55e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    1242 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1321
Cdd:smart00544    1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80

                            90       100       110
                    ....*....|....*....|....*....|...
gi 57997536    1322 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1354
Cdd:smart00544   81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
1509-1592 1.27e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 104.68  E-value: 1.27e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    1509 KLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqqGKGVALKSVTAFFKW 1588
Cdd:smart00515    2 PLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVTW 79


                    ....
gi 57997536    1589 LREA 1592
Cdd:smart00515   80 LQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 1521-1597 1.08e-23

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 96.06  E-value: 1.08e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 57997536   1521 ELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqQGKGVALKSVTAFFKWLREAEEESD 1597
Cdd:pfam02020    1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAE-KGMKKVRKQAKPFVEWLEEAEEESD 76
PHA03247 PHA03247
large tegument protein UL36; Provisional
 20-452 4.43e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 4.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    20 QPAFPPGQTAPVV----FSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVY--PAGSQVMMiPSQ 93
Cdd:PHA03247 2588 RPDAPPQSARPRApvddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRddPAPGRVSR-PRR 2666

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    94 ISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIap 173
Cdd:PHA03247 2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-- 2744

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   174 krerktirirdPNQGGKDITEeimsgARTASTPTPPQTGGGLEPQANGETPQVAViVRPDDRSQGAIIADRPGLPGPEHS 253
Cdd:PHA03247 2745 -----------PAGPATPGGP-----ARPARPPTTAGPPAPAPPAAPAAGPPRRL-TRPAVASLSESRESLPSPWDPADP 2807

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   254 PSESQPSSPSPTPSPSPVlePGSEPNLAVL-------SIPGDTMTTIQMSVEESTPISREtgePYRLSPEPTPLAEPILE 326
Cdd:PHA03247 2808 PAAVLAPAAALPPAASPA--GPLPPPTSAQptappppPGPPPPSLPLGGSVAPGGDVRRR---PPSRSPAAKPAAPARPP 2882

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   327 VEvTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPngmvPSEDLEPEVESSPELAPPPacPSESPVPIAPTAQPEELLNG 406
Cdd:PHA03247 2883 VR-RLARPAVSRSTESFALPPDQPERPPQPQAPPP----PQPQPQPPPPPQPQPPPPP--PPRPQPPLAPTTDPAGAGEP 2955

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 57997536   407 APSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPA 452
Cdd:PHA03247 2956 SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSL 3001
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
405-573 1.30e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 49.87  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   405 NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELL 484
Cdd:PRK12323  369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   485 PPESTPIPANLSQNLEAAAATQ----VAVSVPKRRRKIKElnkKEAVGDLLDAFKEANPAVPEVenqPPAGSNPGPESEG 560
Cdd:PRK12323  449 APAPAPAAAPAAAARPAAAGPRpvaaAAAAAPARAAPAAA---PAPADDDPPPWEELPPEFASP---APAQPDAAPAGWV 522

                         170
                  ....*....|...
gi 57997536   561 SGVPPRPEEADET 573
Cdd:PRK12323  523 AESIPDPATADPD 535
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 328-513 1.50e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.45  E-value: 1.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    328 EVTLSKpVPESEFSSSPLQ-----APTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEE 402
Cdd:pfam05109  418 KVIFSK-APESTTTSPTLNttgfaAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRD 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    403 llNG----------------APSPPAVDLSP-VSEPEEQAKEVTASMAPPTIPSATPatAPSATSPAQEEEMEEEEEEEE 465
Cdd:pfam05109  497 --NGteskapdmtsptsavtTPTPNATSPTPaVTTPTPNATSPTLGKTSPTSAVTTP--TPNATSPTPAVTTPTPNATIP 572

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 57997536    466 GEAGEAGEAESEKGGEELLPP---ESTPIPANLSQNLEAAAATQVAVSVPK 513
Cdd:pfam05109  573 TLGKTSPTSAVTTPTPNATSPtvgETSPQANTTNHTLGGTSSTPVVTSPPK 623
COG5373 COG5373
Uncharacterized membrane protein [Function unknown];
368-450 1.92e-04

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444140 [Multi-domain]  Cd Length: 854  Bit Score: 46.15  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536  368 EDLEPEVESSPELAPPPACPSESPVPIAPTAQPEEllngAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPS 447
Cdd:COG5373   31 EELEAELAEAAEAASAPAEPEPEAAAAATAAAPEA----APAPVPEAPAAPPAAAEAPAPAAAAPPAEAEPAAAPAAASS 106


                 ...
gi 57997536  448 ATS 450
Cdd:COG5373  107 FEE 109
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 761-986 5.14e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.46  E-value: 5.14e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    761 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 840
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    841 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 920
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 57997536    921 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 986
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1438-1570 7.95e-58

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 195.97  E-value: 7.95e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536 1438 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1516
Cdd:cd11559    1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 57997536 1517 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1570
Cdd:cd11559   81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 762-989 1.78e-53

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 186.03  E-value: 1.78e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536     762 RRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlKVPttekptvtvNFRK 841
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNA-KNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536     842 LLLNRCQKEFEKDkdddevfekkqkemdeaataeergrlkeeLEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV 921
Cdd:smart00543   72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 57997536     922 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKT---SSRIRFMLQDVLDLRGSN 989
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELRKNK 200
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1242-1354 4.51e-37

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 135.48  E-value: 4.51e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   1242 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1321
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 57997536   1322 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1354
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1242-1354 4.55e-36

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 132.75  E-value: 4.55e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    1242 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1321
Cdd:smart00544    1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80

                            90       100       110
                    ....*....|....*....|....*....|...
gi 57997536    1322 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1354
Cdd:smart00544   81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
1509-1592 1.27e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 104.68  E-value: 1.27e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    1509 KLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqqGKGVALKSVTAFFKW 1588
Cdd:smart00515    2 PLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVTW 79


                    ....
gi 57997536    1589 LREA 1592
Cdd:smart00515   80 LQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 1521-1597 1.08e-23

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 96.06  E-value: 1.08e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 57997536   1521 ELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqQGKGVALKSVTAFFKWLREAEEESD 1597
Cdd:pfam02020    1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAE-KGMKKVRKQAKPFVEWLEEAEEESD 76
W2 cd11473
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 1439-1564 2.25e-23

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211395  Cd Length: 135  Bit Score: 97.16  E-value: 2.25e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536 1439 PSEELNRQLEKLLKEG-SSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFE----TPLRVDVAVLKARAKLLQK 1513
Cdd:cd11473    2 KNKKLRDSLLKELEEDkSSDVESVKAAKSKLDLDPISLEEVVKVLLTAVVNAVESADsislTQKEQLVLVLKKYGPVLRE 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 57997536 1514 YLCD-EQKELQALYALQALVVT--LEQPPNLLRMFFDALYDEDVVKEDAFYSWE 1564
Cdd:cd11473   82 LLKLiKKDQLYLLLKIEKLCLQlkLSELISLLEKILDLLYDADVLSEEAILSWF 135
W2_eIF2B_epsilon cd11558
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ...
 1508-1597 3.13e-15

C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211396  Cd Length: 169  Bit Score: 74.99  E-value: 3.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536 1508 AKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFK 1587
Cdd:cd11558   80 GPLLENYVKSQDDQVELLLALEEFCLESEEGGPLFAKLLHALYDLDILEEEAILEWWEEPDAGADEEMKKVRELVKKFIE 159

                         90
                 ....*....|
gi 57997536 1588 WLREAEEESD 1597
Cdd:cd11558  160 WLEEAEEESD 169
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 1439-1597 2.72e-09

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 57.63  E-value: 2.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536 1439 PSEELNR--QLEKLLKEGSSNQRVFDwIEANLSEQQIVSNTLVRALmtavcysAIIFETPLRVD-VAVLKARAKLLQKYL 1515
Cdd:cd11561    1 EEEEDERvdELGEFLKKNKDESGLSE-LKEILKEAERLDVVKDKAV-------LVLAEVLFDENiVKEIKKRKALLLKLV 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536 1516 CDEQKELQALYALQALVVtlEQPPNLLRMF---FDALYDEDVVKEDAFYSW---ESSKDPAEQQGKGVaLKSVTAFFKWL 1589
Cdd:cd11561   73 TDEKAQKALLGGIERFCG--KHSPELLKKVpliLKALYDNDILEEEVILKWyekVSKKYVSKEKSKKV-RKAAEPFVEWL 149


                 ....*...
gi 57997536 1590 REAEEESD 1597
Cdd:cd11561  150 EEAEEEEE 157
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 1435-1595 3.76e-08

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 55.30  E-value: 3.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536 1435 QRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSN--------TLVRALMTAVCYSA---IIFETPLRVdvav 1503
Cdd:cd11560   29 YRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSSlpehevvgLLWTALMDAVEWSKkedQIAEQALRH---- 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536 1504 LKARAKLLQKYLCDEQKELQALYALQalVVTLEQPpNLLRMFFD---ALYDEDVVKEDAFYSWesSKDPAEQQGKGVALK 1580
Cdd:cd11560  105 LKKYAPLLAAFCTTARAELALLNKIQ--EYCYENM-KFMKVFQKivkLLYKADVLSEDAILKW--YKKGHSPKGKQVFLK 179

                        170
                 ....*....|....*
gi 57997536 1581 SVTAFFKWLREAEEE 1595
Cdd:cd11560  180 QMEPFVEWLQEAEEE 194
PHA03247 PHA03247
large tegument protein UL36; Provisional
 20-452 4.43e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 4.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    20 QPAFPPGQTAPVV----FSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVY--PAGSQVMMiPSQ 93
Cdd:PHA03247 2588 RPDAPPQSARPRApvddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRddPAPGRVSR-PRR 2666

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    94 ISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIap 173
Cdd:PHA03247 2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-- 2744

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   174 krerktirirdPNQGGKDITEeimsgARTASTPTPPQTGGGLEPQANGETPQVAViVRPDDRSQGAIIADRPGLPGPEHS 253
Cdd:PHA03247 2745 -----------PAGPATPGGP-----ARPARPPTTAGPPAPAPPAAPAAGPPRRL-TRPAVASLSESRESLPSPWDPADP 2807

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   254 PSESQPSSPSPTPSPSPVlePGSEPNLAVL-------SIPGDTMTTIQMSVEESTPISREtgePYRLSPEPTPLAEPILE 326
Cdd:PHA03247 2808 PAAVLAPAAALPPAASPA--GPLPPPTSAQptappppPGPPPPSLPLGGSVAPGGDVRRR---PPSRSPAAKPAAPARPP 2882

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   327 VEvTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPngmvPSEDLEPEVESSPELAPPPacPSESPVPIAPTAQPEELLNG 406
Cdd:PHA03247 2883 VR-RLARPAVSRSTESFALPPDQPERPPQPQAPPP----PQPQPQPPPPPQPQPPPPP--PPRPQPPLAPTTDPAGAGEP 2955

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 57997536   407 APSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPA 452
Cdd:PHA03247 2956 SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSL 3001
PHA03247 PHA03247
large tegument protein UL36; Provisional
 21-576 3.48e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 3.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    21 PAFPPGQTAPVVFSTPQATQMNTPS----QPRQHFYPSR------------------AQPPSSAASRVQSAAPARPGPAA 78
Cdd:PHA03247 2494 AAPDPGGGGPPDPDAPPAPSRLAPAilpdEPVGEPVHPRmltwirgleelasddagdPPPPLPPAAPPAAPDRSVPPPRP 2573

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    79 HVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGA-SPTEFGTYAGAYYPAQgvqqfptg 157
Cdd:PHA03247 2574 APRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpSPSPAANEPDPHPPPT-------- 2645

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   158 vAPAPVLMNQPPqiAPKRERKTIRIRDPnqggkditeeimsgARTASTPTPPQtgGGLEPQANGETPQVAVIVRPDDRSQ 237
Cdd:PHA03247 2646 -VPPPERPRDDP--APGRVSRPRRARRL--------------GRAAQASSPPQ--RPRRRAARPTVGSLTSLADPPPPPP 2706

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   238 GAIIADRPGLPGPEHSPSESQPSspsptpspspvlepGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPyrlSPEP 317
Cdd:PHA03247 2707 TPEPAPHALVSATPLPPGPAAAR--------------QASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG---PPAP 2769

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   318 TPLAEPILEVEVTLSKPVPESEFSSSP-LQAPTPLASHTVEIHEPNGMVPsedlePEVESSPELAPPPACPSESPVPIAP 396
Cdd:PHA03247 2770 APPAAPAAGPPRRLTRPAVASLSESREsLPSPWDPADPPAAVLAPAAALP-----PAASPAGPLPPPTSAQPTAPPPPPG 2844

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   397 TAQPEELLNGAPSPPAvDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAES 476
Cdd:PHA03247 2845 PPPPSLPLGGSVAPGG-DVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP 2923

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   477 EKGGEELLPPESTPIP-ANLSQNLEAAAATQVAVSVPKRRrkikelnkkeavgdlLDAFKEANPAVPEVENQPPAGSNPG 555
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPqPPLAPTTDPAGAGEPSGAVPQPW---------------LGALVPGRVAVPRFRVPQPAPSREA 2988

                         570       580
                  ....*....|....*....|.
gi 57997536   556 PESEGSGVPPRPEEADETWDS 576
Cdd:PHA03247 2989 PASSTPPLTGHSLSRVSSWAS 3009
PHA03247 PHA03247
large tegument protein UL36; Provisional
 116-572 6.81e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 6.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   116 PTQQYPVQPGAPgFYPGASPTEFGTyagayyPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDpnqggkdiTEE 195
Cdd:PHA03247 2478 PVYRRPAEARFP-FAAGAAPDPGGG------GPPDPDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRG--------LEE 2542

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   196 IMSGarTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIiADRPGLPgPEHSPSESQPSSPSPTPSPspvLEPG 275
Cdd:PHA03247 2543 LASD--DAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSR-ARRPDAP-PQSARPRAPVDDRGDPRGP---APPS 2615

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   276 SEPnlavlsiPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEvEVTLSKPV---PESEFSSSPLQAPTPLA 352
Cdd:PHA03247 2616 PLP-------PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPG-RVSRPRRArrlGRAAQASSPPQRPRRRA 2687

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   353 shtveIHEPNGMVPSEDLEPEVESSPELAPPPACPSeSPVPIAPTAQ-----PEELLNGAPSPPAVDLSPVSEPEEQAKE 427
Cdd:PHA03247 2688 -----ARPTVGSLTSLADPPPPPPTPEPAPHALVSA-TPLPPGPAAArqaspALPAAPAPPAVPAGPATPGGPARPARPP 2761

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   428 VTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPI-----PANLSQNLEAA 502
Cdd:PHA03247 2762 TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgplppPTSAQPTAPPP 2841

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   503 AATQVAVSVP-----------KRRRKIKELNKKEAVGDLLDAFKEANPAV---PEVENQPPAGSNPGPESEgSGVPPRPE 568
Cdd:PHA03247 2842 PPGPPPPSLPlggsvapggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVsrsTESFALPPDQPERPPQPQ-APPPPQPQ 2920


                  ....
gi 57997536   569 EADE 572
Cdd:PHA03247 2921 PQPP 2924
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
405-573 1.30e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 49.87  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   405 NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELL 484
Cdd:PRK12323  369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   485 PPESTPIPANLSQNLEAAAATQ----VAVSVPKRRRKIKElnkKEAVGDLLDAFKEANPAVPEVenqPPAGSNPGPESEG 560
Cdd:PRK12323  449 APAPAPAAAPAAAARPAAAGPRpvaaAAAAAPARAAPAAA---PAPADDDPPPWEELPPEFASP---APAQPDAAPAGWV 522

                         170
                  ....*....|...
gi 57997536   561 SGVPPRPEEADET 573
Cdd:PRK12323  523 AESIPDPATADPD 535
rne PRK10811
ribonuclease E; Reviewed
 300-453 2.45e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 49.27  E-value: 2.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   300 STPISR-ETGEPYRLSPEPTPLAEPILeVEVTLSKPVPESEFSSSPLQAPT-PLASHTVEIHEPNGMVPSEDLEPEVESS 377
Cdd:PRK10811  844 RYPVVRpQDVQVEEQREAEEVQVQPVV-AEVPVAAAVEPVVSAPVVEAVAEvVEEPVVVAEPQPEEVVVVETTHPEVIAA 922

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   378 PELAPPP-------ACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATS 450
Cdd:PRK10811  923 PVTEQPQvitesdvAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVA 1002


                  ...
gi 57997536   451 PAQ 453
Cdd:PRK10811 1003 PAQ 1005
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
318-564 9.84e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.15  E-value: 9.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   318 TPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPT 397
Cdd:PRK07003  416 AAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPR 495

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   398 AQPEELLNGAPSPPAVDLSPVSEPEEqakevTASMAPPTiPSATPAtAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESE 477
Cdd:PRK07003  496 AAAPSAATPAAVPDARAPAAASREDA-----PAAAAPPA-PEARPP-TPAAAAPAARAGGAAAALDVLRNAGMRVSSDRG 568

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   478 KGgeellpPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPE 557
Cdd:PRK07003  569 AR------AAAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPPPWEDIPPDDYVPLSA 642


                  ....*..
gi 57997536   558 SEGSGVP 564
Cdd:PRK07003  643 DEGFGGP 649
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 328-513 1.50e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.45  E-value: 1.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    328 EVTLSKpVPESEFSSSPLQ-----APTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEE 402
Cdd:pfam05109  418 KVIFSK-APESTTTSPTLNttgfaAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRD 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    403 llNG----------------APSPPAVDLSP-VSEPEEQAKEVTASMAPPTIPSATPatAPSATSPAQEEEMEEEEEEEE 465
Cdd:pfam05109  497 --NGteskapdmtsptsavtTPTPNATSPTPaVTTPTPNATSPTLGKTSPTSAVTTP--TPNATSPTPAVTTPTPNATIP 572

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 57997536    466 GEAGEAGEAESEKGGEELLPP---ESTPIPANLSQNLEAAAATQVAVSVPK 513
Cdd:pfam05109  573 TLGKTSPTSAVTTPTPNATSPtvgETSPQANTTNHTLGGTSSTPVVTSPPK 623
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 184-445 1.73e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 46.62  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   184 DPNQGGKDITEEIMSGARTAS------------TPTPPQTGgglePQANGETPQVAVIVRPDDRSQGAIIADRP------ 245
Cdd:PRK10263  308 DPLLNGAPITEPVAVAAAATTatqswaapvepvTQTPPVAS----VDVPPAQPTVAWQPVPGPQTGEPVIAPAPegypqq 383

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   246 ---GLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPyrlsPEPTPLAE 322
Cdd:PRK10263  384 sqyAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEE----QQSTFAPQ 459

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   323 PILEVEVTLSKPVPESEFSSSPLQAPTPLASHTV-EIHEPNGMVPSEDLEPEVESS-----PELAP---PPACPSESPVP 393
Cdd:PRK10263  460 STYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEpVVEETKPARPPLYYFEEVEEKrarerEQLAAwyqPIPEPVKEPEP 539

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 57997536   394 IAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATA 445
Cdd:PRK10263  540 IKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLATGAAATVAAPVFSLANS 591
COG5373 COG5373
Uncharacterized membrane protein [Function unknown];
368-450 1.92e-04

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444140 [Multi-domain]  Cd Length: 854  Bit Score: 46.15  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536  368 EDLEPEVESSPELAPPPACPSESPVPIAPTAQPEEllngAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPS 447
Cdd:COG5373   31 EELEAELAEAAEAASAPAEPEPEAAAAATAAAPEA----APAPVPEAPAAPPAAAEAPAPAAAAPPAEAEPAAAPAAASS 106


                 ...
gi 57997536  448 ATS 450
Cdd:COG5373  107 FEE 109
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 140-453 2.03e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 45.72  E-value: 2.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    140 TYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDiTEEIMSGARTA--STPTPPQTGGGLEP 217
Cdd:pfam17823  116 AAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASA-PHAASPAPRTAasSTTAASSTTAASSA 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    218 QANGETPQVAVIVRPDDRSQGAIIADRPGLpGPEHSPSESQPSSPSPTPSPSPVLEPGSepnLAVLSIPGDTMTTIQMSV 297
Cdd:pfam17823  195 PTTAASSAPATLTPARGISTAATATGHPAA-GTALAAVGNSSPAAGTVTAAVGTVTPAA---LATLAAAAGTVASAAGTI 270

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    298 EESTPISRetgepyRLSPeptplaepilevevtlSKPVPESEFSSSPL-----QAPTPLASHTVEihepngmvpsedlEP 372
Cdd:pfam17823  271 NMGDPHAR------RLSP----------------AKHMPSDTMARNPAapmgaQAQGPIIQVSTD-------------QP 315

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    373 EVESSPELAPPPACPSESPvpiaptaqpeellNGAPSPPAVDLSPVSEPEEQAKEVTASMAP-------PTIPSATPATA 445
Cdd:pfam17823  316 VHNTAGEPTPSPSNTTLEP-------------NTPKSVASTNLAVVTTTKAQAKEPSASPVPvlhtsmiPEVEATSPTTQ 382


                   ....*...
gi 57997536    446 PSATSPAQ 453
Cdd:pfam17823  383 PSPLLPTQ 390
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
276-452 4.02e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.25  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   276 SEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPyrlSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHT 355
Cdd:PRK12323  341 SELALAPDEYAGFTMTLLRMLAFRPGQSGGGAGPA---TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAAR 417

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   356 VEIHEPNGMVPSEDLEPEVESSPELAP-----PPACPSESPVPIAPTAQPeellnGAPSPPAVDLSPVSEPEEQAKEVTA 430
Cdd:PRK12323  418 AVAAAPARRSPAPEALAAARQASARGPggapaPAPAPAAAPAAAARPAAA-----GPRPVAAAAAAAPARAAPAAAPAPA 492

                         170       180
                  ....*....|....*....|....*
gi 57997536   431 SMAPP---TIPSATPATAPSATSPA 452
Cdd:PRK12323  493 DDDPPpweELPPEFASPAPAQPDAA 517
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 344-452 4.58e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 44.92  E-value: 4.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   344 PLQAPTPLASHTVEIHEPngmVPSEDLEPEVESSPELAPPPAC------------------PSESPVPIAPTAQPEEL-- 403
Cdd:PLN03209  324 PSQRVPPKESDAADGPKP---VPTKPVTPEAPSPPIEEEPPQPkavvprplspytayedlkPPTSPIPTPPSSSPASSks 400

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 57997536   404 LNGAPSPPAVDLSPVSE-----PEEQAKEVTASMA-------------PPTIPSATPATA--PSATSPA 452
Cdd:PLN03209  401 VDAVAKPAEPDVVPSPGsasnvPEVEPAQVEAKKTrplspyaryedlkPPTSPSPTAPTGvsPSVSSTS 469
PHA03377 PHA03377
EBNA-3C; Provisional
 303-613 5.25e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 45.04  E-value: 5.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   303 ISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIhEPNGMVPSEdlepevESSPELAP 382
Cdd:PHA03377  408 VSRVPWRKPRTLPWPTPKTHPVKRTLVKTSGRSDEAEQAQSTPERPGPSDQPSVPV-EPAHLTPVE------HTTVILHQ 480

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   383 PPacPSESPVPIAPTAQPEELLNGA-----------------------PSPPAVDLSPVSEPEEQAKEVTASMAPPTIPS 439
Cdd:PHA03377  481 PP--QSPPTVAIKPAPPPSRRRRGAcvvydddiievidvetteeeesvTQPAKPHRKVQDGFQRSGRRQKRATPPKVSPS 558

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   440 atpATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIK 519
Cdd:PHA03377  559 ---DRGPPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCKDGPPASGPHEKQPPSSAPRDMAPSVVRMFLR 635

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   520 ELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSgvPPRPEEADETWDSkedKIHNAENIQPGEQKYEYKSD 599
Cdd:PHA03377  636 ERLLEQSTGPKPKSFWEMRAGRDGSGIQQEPSSRRQPATQST--PPRPSWLPSVFVL---PSVDAGRAQPSEESHLSSMS 710

                         330
                  ....*....|....
gi 57997536   600 QWKPLNLEEKKRYD 613
Cdd:PHA03377  711 PTQPISHEEQPRYE 724
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 308-451 9.90e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.93  E-value: 9.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   308 GEPYRLSPEPTPLAEPilevEVTLSKPVPESEFSSSPLQAPTPLAShtveihepngMVPSEDLEPEVESSPELAPPPACP 387
Cdd:PRK14951  369 AAEAAAPAEKKTPARP----EAAAPAAAPVAQAAAAPAPAAAPAAA----------ASAPAAPPAAAPPAPVAAPAAAAP 434

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 57997536   388 SESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEeqakevTASMAPPTIPSATPATAPSATSP 451
Cdd:PRK14951  435 AAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPE------PAVASAAPAPAAAPAAARLTPTE 492
rne PRK10811
ribonuclease E; Reviewed
 344-512 2.80e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 42.33  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   344 PLQAPTPL---------ASHTVEIHEP-----------NGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEEL 403
Cdd:PRK10811  820 PTQSPMPLtvacaspemASGKVWIRYPvvrpqdvqveeQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPV 899

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   404 LNGAPSPPAVDlsPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEEL 483
Cdd:PRK10811  900 VVAEPQPEEVV--VVETTHPEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVA 977

                         170       180
                  ....*....|....*....|....*....
gi 57997536   484 LPPESTPIPANLSQNLEAAAATQVAVSVP 512
Cdd:PRK10811  978 QPAAPVVAEVAAEVETVTAVEPEVAPAQV 1006
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 332-453 3.86e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 3.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   332 SKPVPESEfSSSPLQAPTPLASHTVEIHEPNGMVPsedlePEVESSPELAPPPACPSESPVPIAPTAQPEELlnGAPSPP 411
Cdd:PRK14951  372 AAAPAEKK-TPARPEAAAPAAAPVAQAAAAPAPAA-----APAAAASAPAAPPAAAPPAPVAAPAAAAPAAA--PAAAPA 443

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 57997536   412 AVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQ 453
Cdd:PRK14951  444 AVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAA 485
Rib_recp_KP_reg pfam05104
Ribosome receptor lysine/proline rich region; This highly conserved region is found towards ...
 359-452 5.48e-03

Ribosome receptor lysine/proline rich region; This highly conserved region is found towards the C-terminus of the transmembrane domain. The function is unclear.


Pssm-ID: 461548 [Multi-domain]  Cd Length: 140  Bit Score: 38.95  E-value: 5.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536    359 HEPNGMVPSEDLEPEVESSP-ELAPPPACPSESPVPiAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTI 437
Cdd:pfam05104   44 EKPNGKLPESEQADESEEEPrEFKTPDEAPSAALEP-EPVPTPVPAPVEPEPAPPSESPAPSPKEKKKKEKKSAKVEPAE 122

                           90
                   ....*....|....*
gi 57997536    438 PSATPATAPSATSPA 452
Cdd:pfam05104  123 TPEAVQPKPALEKEE 137
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
274-450 6.68e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 6.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   274 PGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPileVEVTLSKPVPESEFSSSPLQAPTPLAS 353
Cdd:PRK12323  387 PAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAA---RQASARGPGGAPAPAPAPAAAPAAAAR 463

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   354 HTVeihepngmvpsedlepevessPELAPPPACPSESPVPIAPTAQP----------EELLNGAPSPPAVDLSPVSEPEE 423
Cdd:PRK12323  464 PAA---------------------AGPRPVAAAAAAAPARAAPAAAPapadddpppwEELPPEFASPAPAQPDAAPAGWV 522

                         170       180
                  ....*....|....*....|....*..
gi 57997536   424 QAKEVTASMAPPTIPSATPATAPSATS 450
Cdd:PRK12323  523 AESIPDPATADPDDAFETLAPAPAAAP 549
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
323-436 8.84e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 40.72  E-value: 8.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57997536   323 PILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEE 402
Cdd:PRK14948  348 PRLWLEVTLLGLLPSAFISEIANASAPANPTPAPNPSPPPAPIQPSAPKTKQAATTPSPPPAKASPPIPVPAEPTEPSPT 427

                          90       100       110
                  ....*....|....*....|....*....|....
gi 57997536   403 llngaPSPPAVDLSPVSEPEEQAKEVTASMAPPT 436
Cdd:PRK14948  428 -----PPANAANAPPSLNLEELWQQILAKLELPS 456
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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